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819 results on '"McGuigan C"'

12. Early non-disabling relapses are associated with a higher risk of disability accumulation in people with relapsing-remitting multiple sclerosis

Author

Coles, A., Daruwalla, C., Shaygannejad, V., Ozakbas, S., Havrdova, E. K., Alroughani, R., Patti, F., Onofrj, M., Eichau, S., Girard, M., Grand'Maison, F., Yamout, B., Sajedi, S. A., Amato, M. P., Altintas, A., Skibina, O., Grammond, P., Butzkueven, H., Maimone, D., Lechner-Scott, J., Soysal, A., John, N., Gerlach, O., Iuliano, G., Foschi, M., Van Pesch, V., Cartechini, E., Kuhle, J., Sa, M. J., Kermode, A., Gouider, R., Hodgkinson, S., McCombe, P., Sanchez-Menoyo, J. L., Singhal, B., Blanco, Y., Hughes, S., McGuigan, C., Taylor, B., Habek, M., Al-Asmi, A., Mihaela, S., Castillo Trivino, T., Al-Harbi, T., Rojas, J. I., Gray, O., Khurana, D., Van Wijmeersch, B., Kalincik, T., and Brown, J. W. L.

Published
2022

15. Multimodality Anatomic and Molecular Imaging of Parkinson Disease and Atypical Parkinson Syndromes with MRI, Iodine 123 N-ω-Fluoropropyl-2β-Carbomethoxy-3β-(4-Iodophenyl) Nortropane SPECT (Dopamine Transporter SPECT), Iodine 123 Metaiodobenzylguanidine Cardiac Scintigraphy, and [18F] FDG-PET

Author

Duignan, J.A., primary, Haughey, A., additional, Hughes, N.M., additional, Kelly, B.S., additional, Lucey, J.A., additional, McGuigan, C., additional, Kinsella, J.A., additional, and Killeen, R.P., additional

Published
2021
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20. Latitudinal variation in the prevalence of multiple sclerosis in Ireland, an effect of genetic diversity

Author

McGuigan, C., McCarthy, A., Quigley, C., Bannan, L., Hawkins, S.A., and Hutchinson, M.

Subjects
Multiple sclerosis -- Research -- Genetic aspects, Health, Psychology and mental health, Genetic aspects, Research
Abstract

J Neurol Neurosurg Psychiatry 2004;75:572-576. doi: 10.1136/jnnp.2003.012666 Background: Northern Ireland has a high and rising prevalence rate of multiple sclerosis (MS). The most recent survey in 1996 found a rate [...]

Published
2004

21. The multiple sclerosis impact scale (MSIS-29) is a reliable and sensitive measure

Author

McGuigan, C. and Hutchinson, M.

Subjects
Multiple sclerosis -- Research -- Diagnosis, Health, Psychology and mental health, Diagnosis, Research
Abstract

J Neurol Neurosurg Psychiatry 2004;75:266-269 Objective: The aim of this study was to assess the psychometric properties of the Multiple Sclerosis Impact Scale (MSIS-29) for patients in the community and [...]

Published
2004

25. Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis

Author

Brown J, Coles A, Horakova D, Havrdova E, Izquierdo G, Prat A, Girard M, Duquette P, Trojano M, Lugaresi A, Bergamaschi R, Grammond P, Alroughani R, Hupperts R, McCombe P, Van Pesch V, Sola P, Ferraro D, Grand'Maison F, Terzi M, Lechner-Scott J, Flechter S, Slee M, Shaygannejad V, Pucci E, Granella F, Jokubaitis V, Willis M, Rice C, Scolding N, Wilkins A, Pearson O, Ziemssen T, Hutchinson M, Harding K, Jones J, McGuigan C, Butzkueven H, Kalincik T, Robertson N, Onofrj M, De Luca G, Di Tommaso V, Travaglini D, Pietrolongo E, di Ioia M, Farina D, Mancinelli L, Hodgkinson S, Oreja-Guevara C, Boz C, Prevost J, Olascoaga J, Van Wijmeersch B, Barnett M, Verheul F, Rojas J, Spitaleri D, Rio M, Taylor B, Sanchez-Menoyo J, Ramo-Tello C, Solaro C, Csepany T, Iuliano G, Skibina O, Petersen T, Bolanos R, Sidhom Y, Riadh, Vucic S, Macdonell R, Sempere A, Simo M, Kister I, Shuey N, Radek, Dominguez J, Amato M, Saladino M, Kermode A, Butler E, Moore F, Hughes S, McDonnell G, Piroska I, Yamout B, Soysal A, Ozakbas S, Zwanikken C, and MSBase Study Grp

Abstract

IMPORTANCE Within 2 decades of onset, 80% of untreated patients with relapsing-remitting multiple sclerosis (MS) convert to a phase of irreversible disability accrual termed secondary progressiveMS. The association between disease-modifying treatments (DMTs), and this conversion has rarely been studied and never using a validated definition. OBJECTIVE To determine the association between the use, the type of, and the timing of DMTs with the risk of conversion to secondary progressive MS diagnosed with a validated definition. DESIGN, SETTING, AND PARTICIPANTS Cohort study with prospective data from 68 neurology centers in 21 countries examining patients with relapsing-remittingMS commencing DMTs (or clinical monitoring) between 1988-2012 with minimum 4 years' follow-up. EXPOSURES The use, type, and timing of the following DMTs: interferon beta, glatiramer acetate, fingolimod, natalizumab, or alemtuzumab. After propensity-score matching, 1555 patients were included (last follow-up, February 14, 2017). MAIN OUTCOME AND MEASURE Conversion to objectively defined secondary progressiveMS. RESULTS Of the 1555 patients, 1123 were female (mean baseline age, 35 years [SD, 10]). Patients initially treated with glatiramer acetate or interferon beta had a lower hazard of conversion to secondary progressiveMS than matched untreated patients (HR, 0.71; 95% CI, 0.61-0.81; P

Published
2019

33. Spinal claudication due to myxopapillary ependymoma

Author

Stacpoole, S.R.L., McGuigan, C., Lewis, S.J.G., Phadke, R., Stevens, J., Choi, D., and Kapoor, R.

Subjects
Gliomas -- Case studies, Gliomas -- Diagnosis, Gliomas -- Care and treatment, Gliomas -- Demographic aspects, Spinal canal -- Stenosis, Spinal canal -- Case studies, Spinal canal -- Diagnosis, Spinal canal -- Physiological aspects, Spinal canal -- Demographic aspects, Health, Psychology and mental health
Published
2007

36. Dimethyl fumarate modulates the Treg–Th17 cell axis in patients with psoriasis*.

Author

Sulaimani, J., Cluxton, D., Clowry, J., Petrasca, A., Molloy, O.E., Moran, B., Sweeney, C.M., Malara, A., McNicholas, N., McGuigan, C., Kirby, B., and Fletcher, J.M.

Subjects
DIMETHYL fumarate, GRANULOCYTE-macrophage colony-stimulating factor, T helper cells, TH1 cells, T cells
Abstract

Summary: Background: Dimethyl fumarate (DMF) is the active ingredient of Skilarence™ and Tecfidera™, which are used for the treatment of psoriasis and multiple sclerosis, respectively. Various immunomodulatory mechanisms of action have been identified for DMF; however, it is still unclear what effects DMF exerts in vivo in patients with psoriasis. Objectives: In this study we examined the effects of DMF, both in vivo and in vitro, on T cells, which play a key role in the pathogenesis of psoriasis. Methods: The frequency of T‐cell subsets was examined by flow cytometry in untreated patients with psoriasis or those treated with DMF. The effects of DMFin vitro on T‐cell survival, activation and proliferation, and cell‐surface thiols were assessed by flow cytometry. Results: In patients with psoriasis treated with DMF we observed an increase in the frequency of T regulatory (Treg) cells and a decrease in T helper (Th)17 lineage cells and the associated cytokines interleukin‐17, interleukin‐22 and granulocyte–macrophage colony‐stimulating factor. T cells cultured in vitro with DMF exhibited reduced viability, and inhibition of activation and proliferation in response to stimulation due to the oxidative effects of DMF. However, the frequency of Treg cells increased in the presence of DMF due to their heightened ability to resist DMF‐induced oxidative stress. Conclusions: DMF enhanced the ratio of Treg cells to Th17 cells in patients with psoriasis, in patients with multiple sclerosis and in vitro. Furthermore, our data suggest that this is at least in part as a result of the differential effects of DMF on Treg cells compared with conventional T cells. What is already known about this topic? Dimethyl fumarate is an effective treatment for psoriasis and multiple sclerosis.T cells play a key role in the pathogenesis of psoriasis, and the Treg–Th17 cell axis is dysregulated.Multiple mechanisms of action have been described for DMF; however, its effects on T cells in patients with psoriasis have not been elucidated. What does this study add? The Treg to Th17 ratio was enhanced in patients with psoriasis treated with DMF.DMF also increased the ratio of Treg cells to Th17 cells in vitro, by increasing the frequency of Treg cells.Treg cells exhibited an increased ability to resist the oxidative stress induced by DMF in vitro; this is a new mechanism of action for DMF. What is the translational message? The Treg–Th17 axis is known to be dysregulated in psoriasis, and this study indicates that DMF can modulate this axis in favour of regulation.The ability of Treg cells to resist the oxidative stress induced by DMF is likely to contribute to its mechanism of action.The selective reduction of Th17 cells without a reduction in Th1 cells or Treg cells explains the efficacy of DMF in psoriasis. Linked Comment: Mostafa et al. Br J Dermatol 2021; 184:389–390. Plain language summary available online [ABSTRACT FROM AUTHOR]

Published
2021
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37. Progressive multifocal leucoencephalopathy presenting with Parkinsonism

Author

O'Riordan, S., McGuigan, C., Farrell, M., and Hutchinson, M.

Subjects
Encephalopathy -- Development and progression, Encephalopathy -- Research, Parkinsonism -- Complications and side effects, Parkinsonism -- Research, Health
Abstract

Byline: S. O'Riordan (1), C. McGuigan (1), M. Farrell (2), M. Hutchinson (1) Author Affiliation: (1) Dept. of Neurology, St.Vincent's University Hospital, Elm Park, Dublin 4, Ireland (2) Dept. of Neuropathology, Beaumont Hospital, Dublin, Ireland Article History: Registration Date: 01/01/2003 Received Date: 04/11/2002 Accepted Date: 28/05/2003

Published
2003

47. ELM—the database of eukaryotic linear motifs

Author

Dinkel, H., Michael, S., Weatheritt, R. J., Davey, N. E., Van Roey, K., Altenberg, B., Toedt, G., Uyar, B., Seiler, M., Budd, A., Jodicke, L., Dammert, M. A., Schroeter, C., Hammer, M., Schmidt, T., Jehl, P., McGuigan, C., Dymecka, M., Chica, C., Luck, K., Via, A., Chatr-aryamontri, A., Haslam, N., Grebnev, G., Edwards, R. J., Steinmetz, M. O., Meiselbach, H., Diella, F., and Gibson, T. J.

Published
2012
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