12 results on '"McGovern, Aine"'
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2. Prognostic value of estimated glomerular filtration rate in hospitalised older patients (over 65) with COVID-19: a multicentre, European, observational cohort study
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Carter, Ben, Ramsay, Euan A., Short, Roxanna, Goodison, Sarah, Lumsden, Jane, Khan, Amarah, Braude, Philip, Vilches-Moraga, Arturo, Quinn, Terence J., McCarthy, Kathryn, Hewitt, Jonathan, Myint, Phyo K., Bruce, Eilidh, Einarsson, Alice, McCrorie, Kirsty, Aggrey, Ken, Bilan, Jimmy, Hartrop, Kerr, Murphy, Caitlin, McGovern, Aine, Clini, Enrico, Guaraldi, Giovanni, Verduri, Alessia, Bisset, Carly, Alexander, Ross, Kelly, Joanna, Murphy, Caroline, Mutasem, Tarik El Jichi, Singh, Sandeep, Paxton, Dolcie, Harris, Will, Moug, Susan, Galbraith, Norman, Bhatti, Emma, Edwards, Jenny, Duffy, Siobhan, Espinoza, Maria Fernanda Ramon, Kneen, Thomas, Dafnis, Anna, Allafi, Hala, Vidal, Maria Narro, Price, Angeline, Pearce, Lyndsay, Lee, Thomas, Sangani, Shefali, Garcia, Madeline, Davey, Charlotte, Jones, Sheila, Lunstone, Kiah, Cavenagh, Alice, Silver, Charlotte, Telford, Thomas, and Simmons, Rebecca
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Male ,Chronic kidney failure ,SARS-CoV-2 ,RC952-954.6 ,COVID-19 ,Prognosis ,Dose-response ,Cohort Studies ,Geriatrics ,Mortality ,eGFR ,Humans ,Female ,Renal Insufficiency, Chronic ,Geriatrics and Gerontology ,Aged ,Glomerular Filtration Rate - Abstract
Background The reduced renal function has prognostic significance in COVID-19 and it has been linked to mortality in the general population. Reduced renal function is prevalent in older age and thus we set out to better understand its effect on mortality. Methods Patient clinical and demographic data was taken from the COVID-19 in Older People (COPE) study during two periods (February–June 2020 and October 2020–March 2021, respectively). Kidney function on admission was measured using estimated glomerular filtration rate (eGFR). The primary outcomes were time to mortality and 28-day mortality. Secondary outcome was length of hospital stay. Data were analysed with multilevel Cox proportional hazards regression, and multilevel logistic regression and adjusted for individual patient clinical and demographic characteristics. Results One thousand eight hundred two patients (55.0% male; median [IQR] 80 [73–86] years) were included in the study. 28-day mortality was 42.3% (n = 742). 48% (n = 801) had evidence of renal impairment on admission. Using a time-to-event analysis, reduced renal function was associated with increased in-hospital mortality (compared to eGFR ≥ 60 [Stage 1&2]): eGFR 45–59 [Stage 3a] aHR = 1.26 (95%CI 1.02–1.55); eGFR 30–44 [Stage 3b] aHR = 1.41 (95%CI 1.14–1.73); eGFR 1–29 [Stage 4&5] aHR = 1.42 (95%CI 1.13–1.80). In the co-primary outcome of 28-day mortality, mortality was associated with: Stage 3a adjusted odds ratio (aOR) = 1.18 (95%CI 0.88–1.58), Stage 3b aOR = 1.40 (95%CI 1.03–1.89); and Stage 4&5 aOR = 1.65 (95%CI 1.16–2.35). Conclusion eGFR on admission is a good independent predictor of mortality in hospitalised older patients with COVID-19 population. We found evidence of a dose-response between reduced renal function and increased mortality.
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- 2022
3. Test Accuracy of Informant-Based Cognitive Screening Tests for Diagnosis of Dementia and Multidomain Cognitive Impairment in Stroke
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McGovern, Aine, Pendlebury, Sarah T., Mishra, Nishant K., Fan, Yuhua, and Quinn, Terence J.
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- 2016
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4. Age and frailty are independently associated with increased covid-19 mortality and increased care needs in survivors: results of an international multi-centre study
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Alsahab, Mustafa, Beishon, Lucy, Brown, Bryony, Burn, Elinor, Burton, Jenni K, Cox, Natalie, Dani, Melanie, Elhadi, Muhammed, Freshwater, Sarah, Gaunt, Victoria, Gordon, Adam, Goujon, Marie, Hale, Matthew, Hughes, Terry, Jackson, Thomas A, Jelley, Benjamin, Khan, Asma, Khiroya, Heena, Lal, Rajni, Madden, Katy, Magill, Laura, Masoli, Jane, Masud, Tahir, McCluskey, Lauren, McNeela, Natalie, Mohammedseid-Nurhussien, Awolkhier, Moorey, Hannah, Lochlainn, Mary Ni, Nirantharakumar, Krishnarajah, Okoth, Kelvin, Osuafor, Christopher N, Patterson, Katherine, Pearson, Grace M E, Perry, Rita, Pettitt, Michala, Pigott, Jennifer, Pinkney, Thomas, Quinn, Terence, Reynolds, Abigail, Richardson, Sarah, Sanyal, Nik, Seed, Adam, Sleeman, Isobel, Soo, Chee, Steves, Claire, Strain, W David, Taylor, Joanne, Torsney, Kelli, Welch, Carly, Wilson, Daisy, Witham, Miles, Elazeem, Hossam Aldein S Abd, Abdelhafez, Mohammed H, Abdelmalak, Amir, Abdelwahab, Omar A, Abdulhadi, Osama M A S, Adewole, Olubayode, Ahmad, Mohammed, Ahmed, Eltayeb A, Ahmed, Hazem, Ahmed, Islam A, Akcay, Mertcan, Akdeniz, Yeşim, Akın, Emrah, Akladious, Carolyn, Alessandri, Francesco, Ali, Ali, Aljafari, Abdulmalek, Aljafari, Abdulmoiz, Al-Sadawi, Mohammed, Al-Sodani, Lobna, Altintoprak, Fatih, Amaratungaz, Gitanjali, Amer, Jocelyn, Amini, Sylvia, Amir, Taha, Anandarajah, Cheran, Anders, Rachael, Ansari, Muhammed H, Appiah, Kingsley, Atia, Jolene, Atkin, Catherine, Aujayeb, Avinash, Awad, Elsayed M, Azab, Mohammed A, Azam, Mohammad T, Aziz, Sally, Azzam, Ahmed Y, Babar, Laxmi, Babb, Laura, Badh, Manpreet, Baguneid, Clare, Bailey, Emily, Baili, Efstratia, Baldwin, Sarah, Baloyiannis, Ioannis, Bannerjee, Moulinath, Barnard, Anna, Barra, Fabio, Bashir, Hannah, Bawor, Monica, Bayhan, Zülfü, Belcher, James, Belgamwar, Ravindra, Bentley, Corrina, Birchenough, Amy, Bo, Yen Nee J, Boden, Hayley R, Bouhuwaish, Ahmad, Brachini, Gioia, Bremner, Laura, Bridgwater, Hannah, Bryant, Catherine, Budd, Gabrielle, Budd, Sharon, Budzikoski, Adam, Bulla, Reem, Buondonno, Antonio, Burden, Nicole, Butt, Hejab, Capoglu, Recayi, Caracostea, Andra, Cardoso, Rifa, Carr, Alexis, Carrasco-Prats, Milagros, Cattel, Caterina, Ceccarelli, Giancarlo, Cecere, Giuseppe, Charalabopoulos, Alexandros, Charsley, Evelyn, Cheney-Lowe, Hannah, Chevallier, Theodore, Choudhry, Asad J, Ciccarone, Flavia, Cicerchia, Pierfranco M, Cirillo, Bruno, Collins, Fatma D, Comerford, Victoria, Cordie, Ahmed, Coulter, Siobhan, Coulthard, Nick, Cox, Catrin, Cox, Victoria, Crowe, Andrew, Cullen, Jack, Cummings, Jean, Cunningham, Niamh, Curley, Daniel, Currie, Hannah, Daly, Madeleine, Darley, Jay, Dattani, Nikhita, Davakis, Spyridon, Davies, Rowan, De Paola, Gilda, De Toma, Giorgio, Del Valle-Ruiz, Sergio, Deldar, Benyamin, Demir, Hakan, Desai, Arjun, Desai, Nirali, Devaney, Alice, Dew, Lindsey, Dhesi, Jugdeep, Dias, Maria, Dick, Gordon, Doddamani, Parveen, Dogra, Gurinder, Doll, Tina, Dooley, Hannah C, Dost, Samiullah, Dotchin, Catherine, Dowell, Hannah, Draghita, Ioan M, Dundas, James M, Duranti, Giulia, Dusara, Hiren, Dwivedi, Rajesh, Dyer, Adam H, Eastaugh, Alison, Edwards, Elinor, Elghazaly, Shrouk M, Elmehrath, Ahmed O, Elrick, Hope, El-Shazly, Mostafa, Emery, Alexander, Etchill, Eric W, Evans, Sarah, Evison, Felicity, Fairhead, Cassandra, Faulkner, Margherita, Felska, Agnieszka, Fernandez, Antia, Fernández-Fernández, Pedro V, Ferraiolo, Antonella, Ferrero, Simone, Fiori, Enrico, Firat, Necattin, Fisk, Gracie, Fleck, Anna, Fonsi, Giovanni B, Gabre-Kidan, Alodia, Gallo, Gaetano, Gandhi, Ratnam, Garner, Madeleine, Georgiou, Nikolaos, Gerretsen, Hannah, Ghannam, Nourhan A A, Ghobrial, Andrew, Ghobrial, Hedra, Ghufoor, Zaynub, Gibbon, Jake, Gilbert, Georgia F, Giles, Marie, Giménez-Francés, Clara, Gonullu, Emre, Gray, Amy, Gray, Joshua H, Green, Deirdre, Greene, Charlotte, Griffin, Ellanna, Griffith, Karla, Grubb, Anthony, Guan, Yue, Guerero, Daniel N, Gupta, Ayushi, Gustavino, Claudio, Guzman, Laurenny, Hadreiez, Ahmed K M, Hajiioannou, Jiannis, Hanji, Deevia, Madhavan, Deepthy Hari, Harmantepe, Tarık, Harrison, Patrick, Hart, Barbara, Haslam, Aidan, Haunton, Victoria, Haut, Elliott R, Heinsohn, Torben, Hennah, Lindsay, Hetta, Helal F, Hickman, Alexander, Hobill, Abigail, Hogan, Patrick C P, Hogan, Vesna, Holmes, Elizabeth, Honney, Katie, Hood, Katharine, Hopkinson, Katherine, Howells, Lara, Hrouda, Nicole, Hunsley, Danielle, Hurst, William, Hussein, Rand A, Ibrahim, Mohamed Eltaher A A, Ibtida, Ishmam, Ibukunoluwakitan, Aina, Ishlek, Irem, Iyer, Rishi, Jackson, Karl, Jackson, Rosie, James, Ellen, Jarvis, Hayley, Jeffs, Sophie, Jenko, Nathan, Jeyakumar, Sasha, Kabir, Shahriar, Kainth, Harjinder, Kalloo, Jason, Kanzaria, Akhil, Karapanou, Amalia, Kardaman, Nuha, Karthikeyan, Sandeep, Karunatilleke, Anne, Kelly, Mairead, Kelly, Nicola I, Khalid, Hesham, Khan, Haris, Khan, Muhammad S, King, Matthew, Kneen, Thomas, Kok, Li, Kratochwila, Chiara, Kuzeva, Aneliya, Lapolla, Pierfrancesco, Lau, Rebecca, Law, Kar Yee, Leadbetter, Aimee, Lee, Gabriel, Lee, Helena, Levinson, Gavriella, Lewis, Grace, Liakakos, Theodore, Lim, Stephen, Lis, Danielle, Livesey, Emma, López-Morales, Pedro, Lowes, Lily, Lunt, Eleanor, Lyon, Emily, Madan, Suvira, Majid, Zeinab, Malapati, Harsha, Man, Jade, Mandane, Baguiasri, Manning, Sarah H, Mantoglu, Baris, Martínez-Sanz, Nuria, Marx, William, Masood, Almontacer E B, Maughan, Tom, Mawhinney, Jamie, Maxfield, Dominic, Mayer, Jordan, Maynard, Henry, McDonald, Claire, McGovern, Aine, Mclachlan, Sophie, Medina-Manuel, Esther, Meneghini, Simona, Metcalf, Michelle, Millwood-Hargrave, John, Mingoli, Andrea, Miu, Kelvin, Mohamed, Fawsiya, Mohamed, Soha M, Hussein, Aliae A R Mohamed, Mohammad, Abdulkader, Mohammed, Aaliya, Momen, Ahmed A, Moomo, Farhana, Mora-Guzmán, Ismael, Moriarty, Lizzie, Morrin, Hamilton, Morris, Claire, Moss, Nicholas, Moustafa, Mohamed M, Mpoura, Maria, Mubin, Mohammed, Muhtaroglu, Ali, Muir, Georgina, Mulhern, Stephanie, Muller, Daniel, Murphy, Declan C, Muzammil, Bushra, Nadkarni, Varun, Nageh, Mariam Albatoul, NasrEldin, Yasmin K, Nawaz, Wasim, Nguyen, Hanna, Cheallaigh, Cliona Ni, Noar, Alexander, North, Samuel, Nwolu, Favour, O’Docherty, Alice, Odutola, Omoteniola, O’Dwyer, Sinead, Ogochukwu, Olebu, O’Mahony, Catherine, Orlando, Lia, Osterdahl, Marc, Page, Christina, Panayotidis, Ismini, Pancholi, Shivam, Parkin, Jessica, Passby, Lauren C, Pastor-Pérez, Patricia, Patel, Harnish, Patel, Shefali, Penfold, Rose, Perinpanathan, Rupini, Perivoliotis, Konstantinos, Perra, Teresa, Pinkney, Martha, Pinotti, Enrico, Porcu, Alberto, Price, Angeline, Pugliese, Francesco, Puri, Prabhleen, Pytraczyk, Sylvia, Qaiser, Yusra, Qurashi, Maria, Radenkovic, Dina, Rajeswaran, Thurkka, Rapaport, Sarah F, Razzak, Tahmina, Reilly, Lara, Reynolds, Paul, Richardson, Alexandra, Roberts, Amelia, Roberts-Rhodes, Charlotte, Robinson, Tanya, Rocca, Aldo, Ross-Skinner, Emily, Ruiz-Marín, Miguel, Ryall, Rebecca, Saad, Alshaimaa M, Saad, Mahmoud M, Sadiq, Ambreen, Sammarco, Giuseppe, Sampanis, Michail A, Sanghvi, Hazel, Sapienza, Paolo, Sayers, Ross, Scott, Luca, Sen, Michael, Shaban, Mosab A A, Shakespeare, Kathleen T, Shaw, Ellie, Shaw, Hannah, Sheldrake, Jonathan, Sim, Sing Yang, Simonelli, Luigi, Sipsas, Nikolaos V, Sivam, Jarita, Sivarajan, Sri, Smith, Jennifer, Speranza, Fabio, Spice, Claire, Stafford, Amanda, Stambollouian, Katharine, Stevens, Kent A, Stewart, Jack, Stratton, Emma, Street, Hannah, Surtees, Michael, Swinnerton, Emma, Taher, Ahmed S A, Tait, Caroline, Taylor, Amybel, Thake, Miriam, Thin, Katie, Thould, Hannah, Thyn, Thyn, To, Benjaman, Tobiss, Hannah, Toppley, Kathryn, Townsend, Liam, Tullo, Ellen, Tzovaras, George, Umeadi, Anthony, Vaidya, Hrisheekesh, Valero-Soriano, María, Varden, Rosanna, Vergani, Vittoria, Vervoort, Dominique, Vescio, Giuseppina, Vettasseri, Mark, Virk, Madiha, Vyas, Vaishali, Wagland, Joanne, Wallis, Stephanie, Warner, Chloe, Watkins, Eleanor, Watson, Hannah, Webb, Rachael, Welsh, Sarah H, West, Ruth, Whelan, Elisha, Whitney, Julie, Whitsey, Mark, Wilcock, Catherine, Wilkinson, Iain, Williams, David, Williamson, Megan, Willott, Ruth H, Wimalasundera, Mettha, Win, Yu Lelt, Winter, Laura, Worrall, Stephanie, Wright, Rebecca, Yeo, Natalie, Yeung, Eirene, Yigit, Merve, Yildiz, Yasin A, Yusuf, Humza, Zambon, Martina, Zaw, Hein, and Elabedeen, Omar Zein
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Male ,Aging ,medicine.medical_specialty ,Frail Elderly ,COVID-19 ,delirium ,frailty ,mortality ,transitions of care ,Cohort Studies ,AcademicSubjects/MED00280 ,Interquartile range ,Internal medicine ,medicine ,Dementia ,Humans ,Survivors ,Aged ,Proportional hazards model ,business.industry ,SARS-CoV-2 ,Hazard ratio ,Odds ratio ,General Medicine ,medicine.disease ,Confidence interval ,frailty,COVID-19 ,Ageing ,Delirium ,Female ,medicine.symptom ,Geriatrics and Gerontology ,business ,Cohort study ,Research Paper - Abstract
Introduction Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty has been unclear. Methods This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation and co-morbidities. We used ordinal logistic regression analysis to assess the impact of age, Clinical Frailty Scale (CFS) and delirium on risk of increased care requirements on discharge, adjusting for the same variables. Results Data from 5,711 patients from 55 hospitals in 12 countries were included (median age 74, interquartile range [IQR] 54–83; 55.2% male). The risk of death increased independently with increasing age (>80 versus 18–49: hazard ratio [HR] 3.57, confidence interval [CI] 2.54–5.02), frailty (CFS 8 versus 1–3: HR 3.03, CI 2.29–4.00) inflammation, renal disease, cardiovascular disease and cancer, but not delirium. Age, frailty (CFS 7 versus 1–3: odds ratio 7.00, CI 5.27–9.32), delirium, dementia and mental health diagnoses were all associated with increased risk of higher care needs on discharge. The likelihood of adverse outcomes increased across all grades of CFS from 4 to 9. Conclusion Age and frailty are independently associated with adverse outcomes in COVID-19. Risk of increased care needs was also increased in survivors of COVID-19 with frailty or older age.
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- 2021
5. Multiple House Occupancy is Associated with Mortality in Hospitalised Patients with Covid-19
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Bruce, Eilidh, Carter, Ben, Quinn, Terence J, Verduri, Alessia, Pearson, Oliver, Vilches-Moraga, Arturo, Price, Angeline, Mcgovern, Aine, Evans, Louis, Mccarthy, Kathryn, Hewitt, Jonathan, Moug, Susan, Myint, Phyo K, Behalf Of Cope Study Team, Null, Einarsson, Alice, Fleck, Anna, Bisset, Carly, Alexander, Ross, Guaraldi, Giovanni, Murphy, Caroline, Kelly, Joanna, Short, Roxanna, Braude, Philip, El Jichi Mutasem, Tarik, Singh, Sandeep, Paxton, Dolcie, Harris, Will, Hesford, James, Holloway, Mark, Mitchell, Emma, Rickard, Frances, Galbraith, Norman, Bhatti, Emma, Edwards, Jenny, Duffy, Siobhan, Barlow-Pay, Fenella, Pearce, Lyndsey, Garcia, Madeline, Sangani, Shefali, Kneen, Thomas, Lee, Thomas, Davey, Charlotte, Jones, Sheila, Lunstone, Kiah, Cavenagh, Alice, Silver, Charlotte, Telford, Thomas, Simmons, Rebecca, and Stechman, Michael
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Male ,Occupancy ,Original Manuscript ,Logistic regression ,Cohort Studies ,Pandemic ,Coronavirus ,Covid-19 ,Multiple House occupancy ,medicine ,Humans ,AcademicSubjects/MED00860 ,AcademicSubjects/SOC01210 ,Pandemics ,Aged ,COPD ,Proportional hazards model ,business.industry ,SARS-CoV-2 ,Public Health, Environmental and Occupational Health ,COVID-19 ,medicine.disease ,Hospitalization ,Heart failure ,Population study ,Female ,business ,AcademicSubjects/SOC02610 ,Demography ,Cohort study - Abstract
Background In response to the COVID-19 pandemic, many countries mandated staying at home to reduce transmission. This study examined the association between living arrangements (house occupancy numbers) and outcomes in COVID-19. Methods Study population was drawn from the COPE study, a multicentre cohort study. House occupancy was defined as: living alone; living with one other person; living with multiple other people; or living in a nursing/residential home. Outcomes were time from admission to mortality and discharge (Cox regression), and Day 28 mortality (logistic regression) analyses were adjusted for key comorbidities and covariates including admission: age, sex, smoking, heart failure, admission C-reactive protein (CRP), chronic obstructive pulmonary disease, estimated glomerular filtration rate, frailty and others. Results A total of 1584 patients were included from 13 hospitals across UK and Italy: 676 (42.7%) were female, 907 (57.3%) were male, median age was 74 years (range: 19–101). At 28 days, 502 (31.7%) had died. Median admission CRP was 67, 82, 79.5 and 83 mg/l for those living alone, with someone else, in a house of multiple occupancy and in a nursing/residential home, respectively. Compared to living alone, living with anyone was associated with increased mortality: within a couple [adjusted hazard ratios (aHR) = 1.39, 95% confidence intervals (CI) 1.09–1.77, P = 0.007]; living in a house of multiple occupancy (aHR = 1.67, 95% CI 1.17–2.38, P = 0.005); and living in a residential home (aHR = 1.36, 95% CI 1.03–1.80, P = 0.031). Conclusion For patients hospitalized with COVID-19, those living with one or more people had an increased association with mortality, they also exhibited higher CRP indicating increased disease severity suggesting they delayed seeking care.
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- 2021
6. sj-pdf-1-taw-10.1177_2042098620985690 – Supplemental material for Routine use of immunosuppressants is associated with mortality in hospitalised patients with COVID-19
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Phyo K. Myint, Carter, Ben, Barlow-Pay, Fenella, Short, Roxanna, Einarsson, Alice G., Bruce, Eilidh, McCarthy, Kathryn, Verduri, Alessia, Jemima Collins, Hesford, James, Rickard, Frances, Mitchell, Emma, Holloway, Mark, McGovern, Aine, Vilches-Moraga, Arturo, Braude, Philip, Pearce, Lyndsay, Stechman, Michael, Price, Angeline, Quinn, Terence J., Clini, Enrico, Moug, Susan, and Hewitt, Jonathan
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FOS: Clinical medicine ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,111299 Oncology and Carcinogenesis not elsewhere classified - Abstract
Supplemental material, sj-pdf-1-taw-10.1177_2042098620985690 for Routine use of immunosuppressants is associated with mortality in hospitalised patients with COVID-19 by Phyo K. Myint, Ben Carter, Fenella Barlow-Pay, Roxanna Short, Alice G. Einarsson, Eilidh Bruce, Kathryn McCarthy, Alessia Verduri, Jemima Collins, James Hesford, Frances Rickard, Emma Mitchell, Mark Holloway, Aine McGovern, Arturo Vilches-Moraga, Philip Braude, Lyndsay Pearce, Michael Stechman, Angeline Price, Terence J. Quinn, Enrico Clini, Susan Moug and Jonathan Hewitt in Therapeutic Advances in Drug Safety
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- 2021
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7. Routine use of immunosuppressants is associated with mortality in hospitalised patients with COVID-19
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Myint, Phyo K., primary, Carter, Ben, additional, Barlow-Pay, Fenella, additional, Short, Roxanna, additional, Einarsson, Alice G., additional, Bruce, Eilidh, additional, McCarthy, Kathryn, additional, Verduri, Alessia, additional, Collins, Jemima, additional, Hesford, James, additional, Rickard, Frances, additional, Mitchell, Emma, additional, Holloway, Mark, additional, McGovern, Aine, additional, Vilches-Moraga, Arturo, additional, Braude, Philip, additional, Pearce, Lyndsay, additional, Stechman, Michael, additional, Price, Angeline, additional, Quinn, Terence J., additional, Clini, Enrico, additional, Moug, Susan, additional, and Hewitt, Jonathan, additional
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- 2021
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8. Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19
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Bruce, Eilidh, primary, Barlow-Pay, Fenella, additional, Short, Roxanna, additional, Vilches-Moraga, Arturo, additional, Price, Angeline, additional, McGovern, Aine, additional, Braude, Philip, additional, Stechman, Michael J., additional, Moug, Susan, additional, McCarthy, Kathryn, additional, Hewitt, Jonathan, additional, Carter, Ben, additional, and Myint, Phyo Kyaw, additional
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- 2020
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9. The effect of frailty on survival in patients with COVID-19 (COPE): a multicentre, European, observational cohort study
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Hewitt, Jonathan, primary, Carter, Ben, additional, Vilches-Moraga, Arturo, additional, Quinn, Terence J, additional, Braude, Philip, additional, Verduri, Alessia, additional, Pearce, Lyndsay, additional, Stechman, Michael, additional, Short, Roxanna, additional, Price, Angeline, additional, Collins, Jemima T, additional, Bruce, Eilidh, additional, Einarsson, Alice, additional, Rickard, Frances, additional, Mitchell, Emma, additional, Holloway, Mark, additional, Hesford, James, additional, Barlow-Pay, Fenella, additional, Clini, Enrico, additional, Myint, Phyo K, additional, Moug, Susan J, additional, McCarthy, Kathryn, additional, Davey, Charlotte, additional, Jones, Sheila, additional, Lunstone, Kiah, additional, Cavenagh, Alice, additional, Silver, Charlotte, additional, Telford, Thomas, additional, Simmons, Rebecca, additional, Mutasem, Tarik El Jichi, additional, Singh, Sandeep, additional, Paxton, Dolcie, additional, Harris, Will, additional, Galbraith, Norman, additional, Bhatti, Emma, additional, Edwards, Jenny, additional, Duffy, Siobhan, additional, Bisset, Carly, additional, Alexander, Ross, additional, Garcia, Madeline, additional, Sangani, Shefali, additional, Kneen, Thomas, additional, Lee, Thomas, additional, McGovern, Aine, additional, and Guaraldi, Giovanni, additional
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- 2020
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10. Routine Use of Immunosuppressants is Associated with Mortality in Hospitalised Patients with COVID-19
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Myint, Phyo K, primary, Carter, Ben, additional, Barlow-Pay, Fenella, additional, Short, Roxanna, additional, Einarsson, Alice G, additional, Bruce, Eilidh, additional, McCarthy, Kathryn, additional, Verduri, Alessia, additional, Collins, Jemima, additional, Hesford, James, additional, Rickard, Frances, additional, Mitchell, Emma, additional, Halloway, Mark, additional, McGovern, Aine, additional, Vilches-Moraga, Arturo, additional, Braude, Philip, additional, Pearce, Lyndsay, additional, Stechman, Michael, additional, Price, Angeline, additional, Quinn, Terence J, additional, Clini, Enrico, additional, Moug, Susan J, additional, and Hewitt, Jonathan, additional
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- 2020
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11. Community Members' Perceptions of Evidence: The Effects of Gender in a Recovered Memory Civil Trial
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ForsterLee, Robert, Ho, Robert, ForsterLee Lynne, Horowitz, Irwin A., and McGovern, Aine
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Recovered memory (Psychology) -- Analysis ,Jury members -- Psychological aspects ,Psychological abuse -- Investigations ,Parties to actions -- Psychological aspects ,Sex differences -- Analysis ,Psychology and mental health ,Social sciences - Abstract
Community members judged a civil trial in which a memory had either been recovered or kept secret until therapy 12 years later. Female jurors were more likely to find the defendant liable and to compensate female plaintiffs more than male plaintiffs, whereas the reverse pattern held for male jurors. Female plaintiffs who reported recovered memories were compensated least, whereas female plaintiffs who kept the abuse secret were compensated most. A mediational model was posited and results indicated that the origin of the memory of sexual abuse and victim gender influenced assessments of trial testimonies that were related to the trial outcomes. Results supported the postulated model and indicated significant juror-gender differences in evaluating and weighing the evidence.
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- 1999
12. Multiple house occupancy is associated with mortality in hospitalized patients with COVID-19.
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Bruce, Eilidh, Carter, Ben, Quinn, Terence J, Verduri, Alessia, Pearson, Oliver, Vilches-Moraga, Arturo, Price, Angeline, McGovern, Aine, Evans, Louis, McCarthy, Kathryn, Hewitt, Jonathan, Moug, Susan, Myint, Phyo K, and Team, COPE Study
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RESEARCH ,HOSPITAL patients ,COVID-19 ,CONFIDENCE intervals ,MEDICAL cooperation ,DESCRIPTIVE statistics ,HOUSING ,LOGISTIC regression analysis ,LONGITUDINAL method - Abstract
Background In response to the COVID-19 pandemic, many countries mandated staying at home to reduce transmission. This study examined the association between living arrangements (house occupancy numbers) and outcomes in COVID-19. Methods Study population was drawn from the COPE study, a multicentre cohort study. House occupancy was defined as: living alone; living with one other person; living with multiple other people; or living in a nursing/residential home. Outcomes were time from admission to mortality and discharge (Cox regression), and Day 28 mortality (logistic regression) analyses were adjusted for key comorbidities and covariates including admission: age, sex, smoking, heart failure, admission C-reactive protein (CRP), chronic obstructive pulmonary disease, estimated glomerular filtration rate, frailty and others. Results A total of 1584 patients were included from 13 hospitals across UK and Italy: 676 (42.7%) were female, 907 (57.3%) were male, median age was 74 years (range: 19–101). At 28 days, 502 (31.7%) had died. Median admission CRP was 67, 82, 79.5 and 83 mg/l for those living alone, with someone else, in a house of multiple occupancy and in a nursing/residential home, respectively. Compared to living alone, living with anyone was associated with increased mortality: within a couple [adjusted hazard ratios (aHR) = 1.39, 95% confidence intervals (CI) 1.09–1.77, P = 0.007]; living in a house of multiple occupancy (aHR = 1.67, 95% CI 1.17–2.38, P = 0.005); and living in a residential home (aHR = 1.36, 95% CI 1.03–1.80, P = 0.031). Conclusion For patients hospitalized with COVID-19, those living with one or more people had an increased association with mortality, they also exhibited higher CRP indicating increased disease severity suggesting they delayed seeking care. [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
- View/download PDF
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