9 results on '"McGonagle B"'
Search Results
2. Pulmonary hypertension-related deaths in patients with acute pulmonary embolism in the United States, 2003 to 2020.
- Author
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Zuin M, Badagliacca R, Harder E, McGonagle B, Greason C, and Piazza G
- Subjects
- Humans, Male, United States epidemiology, Female, Aged, Middle Aged, Risk Factors, Aged, 80 and over, Time Factors, Adult, SARS-CoV-2, Risk Assessment, Pulmonary Embolism mortality, Pulmonary Embolism diagnosis, Pulmonary Embolism epidemiology, COVID-19 mortality, COVID-19 epidemiology, COVID-19 complications, Hypertension, Pulmonary mortality, Hypertension, Pulmonary epidemiology, Hypertension, Pulmonary diagnosis
- Abstract
Background: Data regarding the mortality trends in pulmonary embolism (PE)-related mortality in patients with concomitant pulmonary hypertension (PH) are lacking. We assessed the trends in PE-related mortality in patients with concomitant PH in the United States (US) over the past 2 decades and during the first year of the COVID-19 pandemic using data from the Centers for Disease Control and Prevention's (CDC) Wide-ranging ONline Data for Epidemiologic Research (WONDER) dataset., Methods: Mortality data were retrieved from the publicly available CDC WONDER mortality dataset from 2003 to 2020. Age-adjusted mortality rates (AAMRs), per 100,000 population, were assessed using Joinpoint regression modelling and expressed as estimated average annual percentage change (AAPC) with relative 95% CIs and stratified by urbanicity, sex, age, and race/ethnicity., Results: Over the study period, the AAMR for PE/PH-related mortality linearly increased (AAPC: +4.3% [95% CI: 3.7 to 4.9], p < 0.001) without sex differences. The AAMR increase was more pronounced in White individuals (AAPC: +4.8% [95% CI: 4.1 to 5.5], p < 0.001) and in subjects living in rural areas (AAPC: +5.1% [95% CI: 3.8 to 6.4], p < 0.001) compared to those living in urban areas. During the first year of the COVID-19 pandemic there was a significant excess in PE/PH-related mortality among women, older than 65 years and living in rural areas., Conclusions: The rate of PE/PH-related mortality in the US is increasing. Although the early diagnosis of PH in patients with acute PE has become easier with improved diagnostic modalities, the mortality rate of these patients remains high., Competing Interests: Declaration of conflicting interestsGregory Piazza received research support from Bristol-Myers Squibb/Pfizer Alliance, Bayer, Janssen, Alexion, Amgen, and Boston Scientific Corporation, and consulting fees from Pfizer, Boston Scientific Corporation, Janssen, and Amgen. The other authors have no conflicts of interest to declare. more...
- Published
- 2024
- Full Text
- View/download PDF
Catalog
3. Pharmacokinetic and Pharmacodynamic Interactions between Food or Herbal Products and Oral Anticoagulants: Evidence Review, Practical Recommendations, and Knowledge Gaps.
- Author
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Talasaz AH, McGonagle B, HajiQasemi M, Ghelichkhan ZA, Sadeghipour P, Rashedi S, Cuker A, Lech T, Goldhaber SZ, Jennings DL, Piazza G, and Bikdeli B
- Abstract
Interactions between food and oral anticoagulants (OACs), particularly vitamin K antagonists such as warfarin, are widely recognized and may also be clinically relevant for direct OACs. Pharmacokinetic and pharmacodynamic interactions with food or herbs can lead to anticoagulation potentiation, increased risk of bleeding, or reduced drug efficacy, all compromising patient safety. We conducted a systematic search for randomized controlled trials (RCTs) on PubMed for assessments of interactions between OACs and various ingestants. Since the RCT evidence was slim, we also reviewed prospective longitudinal studies, case series, and case reports to identify possible associations between foods and anticoagulation therapy. We referred to basic or translational studies that shared putative explanations for such interactions, but we failed to identify high-quality evidence in most cases. The limited evidence, small sample size of the studies, conflicting results, and possible heterogeneity in the contents of herbal products prevent a conclusive assessment of these interactions. Existing evidence suggests that (1) cranberry juice consumption (up to 240 mL/d and probably even more) with warfarin is safe; (2) use of green leafy vegetables with a high daily content (more than 250 µg) of vitamin K should be cautioned for patients receiving warfarin, because it may decrease warfarin efficacy. It is also advisable for patients to maintain highly constant intake of green leafy vegetables to ensure stable warfarin effectiveness; (3) ginger, even in small quantities (excluding commercial ginger-flavored beverages, which contain only negligible amounts of ginger), and mango (more than one fruit) can both potentiate warfarin effects; (4) patients taking OACs should avoid St. John's wort due to diminished anticoagulant effect; and (5) consumption of less than 240 mL of grapefruit juice daily is unlikely to interact with OACs. Future longitudinal observational cohort studies and RCTs with larger sample sizes are needed to study specific interactions between food or herbal products and OACs., Competing Interests: Outside the submitted work, A.C. has served as a consultant for MingSight, Pfizer, Sanofi, and Synergy and has received authorship royalties from UpToDate. G.P. received funding as Research Grants (paid to his institution from BMS/Pfizer, Janssen, Alexion, Bayer, Amgen, BSC, Esperion, 1R01HL164717-01) and has Advisory Roles in BSC, Amgen, BCRI, PERC, NAMSA, BMS, Janssen, Regeneron. Outside the submitted work, B.B. is supported by a Career Development Award from the American Heart Association and VIVA Physicians (#938814). B.B. was supported by the Scott Schoen and Nancy Adams IGNITE Award and is supported by the Mary Ann Tynan Research Scientist award from the Mary Horrigan Connors Center for Women's Health and Gender Biology at the Brigham and Women's Hospital, and the Heart and Vascular Center Junior Faculty Award from the Brigham and Women's Hospital. B.B. reports that he was a consulting expert, on behalf of the plaintiff, for litigation related to two specific brand models of inferior vena cava (IVC) filters. B.B. has not been involved in the litigation in 2022 to 2024 nor has he received any compensation in 2022 to 2024. B.B. reports that he is a member of the Medical Advisory Board for the North American Thrombosis Forum and serves in the Data Safety and Monitory Board of the NAIL-IT trial funded by the National Heart, Lung, and Blood Institute, and Translational Sciences. B.B. is a collaborating consultant with the International Consulting Associates and the U.S. Food and Drug Administration in a study to generate knowledge about utilization, predictors, retrieval, and safety of IVC filters. B.B. receives compensation as an Associated Editor for the New England Journal of Medicine Journal Watch Cardiology, as an Associate Editor for Thrombosis Research, and as an Executive Associate Editor for JACC, and is a Section Editor for Thrombosis and Haemostasis (no compensation)., (Thieme. All rights reserved.) more...
- Published
- 2024
- Full Text
- View/download PDF
4. V(D)J recombinase-mediated processing of coding junctions at cryptic recombination signal sequences in peripheral T cells during human development.
- Author
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Murray JM, O'Neill JP, Messier T, Rivers J, Walker VE, McGonagle B, Trombley L, Cowell LG, Kelsoe G, McBlane F, and Finette BA
- Subjects
- Adolescent, Age Factors, Base Sequence, Child, Child, Preschool, Female, Fetus, Gene Rearrangement, Humans, Hypoxanthine Phosphoribosyltransferase genetics, Infant, Infant, Newborn, Male, Nucleotides, Sex Factors, Genetic Code, Growth and Development immunology, Recombination, Genetic, T-Lymphocytes, VDJ Recombinases physiology
- Abstract
V(D)J recombinase mediates rearrangements at immune loci and cryptic recombination signal sequences (cRSS), resulting in a variety of genomic rearrangements in normal lymphocytes and leukemic cells from children and adults. The frequency at which these rearrangements occur and their potential pathologic consequences are developmentally dependent. To gain insight into V(D)J recombinase-mediated events during human development, we investigated 265 coding junctions associated with cRSS sites at the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in peripheral T cells from 111 children during the late stages of fetal development through early adolescence. We observed a number of specific V(D)J recombinase processing features that were both age and gender dependent. In particular, TdT-mediated nucleotide insertions varied depending on age and gender, including percentage of coding junctions containing N-nucleotide inserts, predominance of GC nucleotides, and presence of inverted repeats (Pr-nucleotides) at processed coding ends. In addition, the extent of exonucleolytic processing of coding ends was inversely related to age. We also observed a coding-partner-dependent difference in exonucleolytic processing and an age-specific difference in the subtypes of V(D)J-mediated events. We investigated these age- and gender-specific differences with recombination signal information content analysis of the cRSS sites in the human HPRT locus to gain insight into the mechanisms mediating these developmentally specific V(D)J recombinase-mediated rearrangements in humans. more...
- Published
- 2006
- Full Text
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5. The effect of hyaluronidase and dimethyl sulfoxide (DMSO) on experimental skin flap survival.
- Author
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Grossman JA, McGonagle BA, Dowden RV, and Dinner MI
- Subjects
- Animals, Female, Necrosis, Rats, Skin pathology, Dimethyl Sulfoxide therapeutic use, Graft Survival drug effects, Hyaluronoglucosaminidase therapeutic use, Surgical Flaps
- Abstract
Hyaluronidase has been shown clinically and experimentally to reduce the effects of tissue ischemia in myocardial infarction and hemorrhagic shock. Dimethyl sulfoxide (DMSO) has been shown to reverse the effects of cerebral ischemia in the primate model. A caudally based dorsal skin flap in the rat was used to study the effects of these two drugs in physiological doses on skin flaps, and to investigate their mechanisms of action. This study demonstrates that both hyaluronidase and DMSO, which are nontoxic in physiological doses, can increase the surviving length of an experimental skin flap. It is hypothesized that these substances exert their effect by decreasing tissue edema and by aiding in the transport of nutritive substances to the flap during its acute phase. more...
- Published
- 1983
- Full Text
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6. Postoperative perineal hernia.
- Author
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Beck DE, Fazio VW, Jagelman DG, Lavery IC, and McGonagle BA
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Surgical Mesh, Herniorrhaphy, Perineum surgery, Postoperative Complications surgery
- Abstract
Eight patients (seven male and one female) with symptomatic postoperative perineal hernias treated at the Cleveland Clinic Foundation from 1975 to 1986 are reviewed. The patients ranged in age from 43 to 68 years (mean, 61 years). Seven had previous abdominoperineal resections of the rectum and one had a pelvic exenteration. The first two patients underwent repair via a perineal approach and both had recurrences of their hernias. These recurrences, as well as the presenting hernias in the six later patients, were repaired with mesh placed through an abdominal approach. Of these, there was one recurrence, which was repaired via an abdominal approach. There was no operative mortality. Based on experience, the authors believe that the best method of repair for this uncommon problem, involves placement of Marlex mesh across the pelvic inlet through an abdominal approach. This allows attachment of the mesh to the lateral musculature and posterior sacral periosteum under direct vision. The anterior borders of the mesh can be secured to the apex of the vaginal or prostatic tissue. The placement of metallic clips to the edges of the mesh allows for confirmation of the mesh position by radiographic examination during follow-up. more...
- Published
- 1987
- Full Text
- View/download PDF
7. Villous and tubulovillous adenomas of the colon and rectum. A retrospective review, 1964-1985.
- Author
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Galandiuk S, Fazio VW, Jagelman DG, Lavery IC, Weakley FA, Petras RE, Badhwar K, McGonagle B, Eastin K, and Sutton T
- Subjects
- Adenocarcinoma surgery, Adolescent, Adult, Aged, Child, Colonic Neoplasms surgery, Female, Humans, Male, Medical Records, Middle Aged, Neoplasm Recurrence, Local, Postoperative Complications, Prognosis, Rectal Neoplasms surgery, Retrospective Studies, Adenocarcinoma pathology, Colonic Neoplasms pathology, Rectal Neoplasms pathology
- Abstract
The records of 1,040 patients with 1,440 villous and tubulovillous adenomas of the colon and rectum treated at the Cleveland Clinic over a 21 year period were reviewed. The incidence of invasive adenocarcinoma was higher in patients with multiple adenomas at the time of presentation, in patients with a family history of colorectal cancer, and in those with adenomas greater than 4 cm in diameter. Eighty percent of the adenocarcinomas were Dukes' A or B, 15 percent were Dukes' C, and 5 percent presented with distant metastases. Clinical impression on examination was more accurate than biopsy in assessing the presence of malignancy in these tumors. Recurrence after local treatment of both benign and malignant tumors was high. Recurrence was significantly related to the size of the adenoma (more common when the tumor was more than 4 cm in diameter), location (more common when it was located in the rectum), and the type of treatment. Only 4 percent of the patients had died from colorectal cancer at the time of follow-up. The overall 5 year actuarial survival rate was 85 percent. more...
- Published
- 1987
- Full Text
- View/download PDF
8. Visual interpretation of fluorescein penetration and ultimate flap survival.
- Author
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Grossman JA and McGonagle BA
- Subjects
- Animals, Male, Swine, Fluoresceins, Graft Survival, Surgical Flaps
- Published
- 1982
- Full Text
- View/download PDF
9. The Chilaiditi syndrome and associated volvulus of the transverse colon. An indication for surgical therapy.
- Author
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Orangio GR, Fazio VW, Winkelman E, and McGonagle BA
- Subjects
- Adult, Colon diagnostic imaging, Colon surgery, Colonic Diseases diagnostic imaging, Colonic Diseases surgery, Humans, Intestinal Obstruction diagnostic imaging, Intestinal Obstruction surgery, Male, Radiography, Syndrome, Colon abnormalities, Colonic Diseases complications, Intestinal Obstruction complications
- Abstract
Hepatodiaphragmatic interposition of the colon is a rare anomaly described by Chilaiditi in 1910. Usually this syndrome presents as an asymptomatic roentgen finding, although occasionally it is associated with a broad range of gastrointestinal symptoms. The hallmark of therapy is conservative, and rarely has surgical intervention been indicated. This is the only case report of the Chilaiditi syndrome associated with colonic volvulus. It also illustrates the rare progression of colonic interposition from mild abdominal discomfort to intermittent bowel obstruction requiring surgical intervention. more...
- Published
- 1986
- Full Text
- View/download PDF
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