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Objective: To evaluate the effect of monochromatic infrared photo energy (MIRE[TM]) combined with physical therapy in reducing pain, improving sensation, and increasing balance in patients with peripheral neuropathy. Methods: Pain [VAS scale], diminished foot sensation [Semmes Weinstein Monofilament 5.07], and balance deficits [Tinetti Assessment Tool] of 272 patients, average age 69 years, were documented before and after receiving treatments at eight physical therapy clinics. Results: Neuropathic pain, diminished foot sensation, and balance impairments at baseline were present in 93% of patients. After an average of 18 treatments, neuropathic pain decreased by 38%, lower extremity sensory impairment improved by 77%, and balance deficits decreased by 73% [P < 0.006 for all results]. Conclusions: Compared with the literature, preliminary findings suggest that MIRE[TM] plus manual physical therapy improves pain, balance, and sensation symptoms in patients with peripheral neuropathy, at least temporarily. [ABSTRACT FROM AUTHOR]

Selecting a cohort from a set of candidates is a common task within and beyond academia. Admitting students, awarding grants, and choosing speakers for a conference are situations where human biases may affect the selection of any particular candidate, and, thereby the composition of the final cohort. In this paper, we propose a new algorithm, entrofy, designed to be part of a human-in-the-loop decision making strategy aimed at making cohort selection as just, transparent, and accountable as possible. We suggest embedding entrofy in a two-step selection procedure. During a merit review, the committee selects all applicants, submissions, or other entities that meet their merit-based criteria. This often yields a cohort larger than the admissible number. In the second stage, the target cohort can be chosen from this meritorious pool via a new algorithm and software tool called entrofy. entrofy optimizes differences across an assignable set of categories selected by the human committee. Criteria could include academic discipline, home country, experience with certain technologies, or other quantifiable characteristics. The entrofy algorithm then yields the approximation of pre-defined target proportions for each category by solving the tie-breaking problem with provable performance guarantees. We show how entrofy selects cohorts according to pre-determined characteristics in simulated sets of applications and demonstrate its use in a case study of Astro Hack Week. This two stage candidate and cohort selection process allows human judgment and debate to guide the assessment of candidates' merit in step 1. Then the human committee defines relevant diversity criteria which will be used as computational parameters in entrofy. Once the parameters are defined, the set of candidates who meet the minimum threshold for merit are passed through the entrofy cohort selection procedure in step 2 which yields a cohort of a composition as close as possible to the computational parameters defined by the committee. This process has the benefit of separating the meritorious assessment of candidates from certain elements of their diversity and from some considerations around cohort composition. It also increases the transparency and auditability of the process, which enables, but does not guarantee, fairness. Splitting merit and diversity considerations into their own assessment stages makes it easier to explain why a given candidate was selected or rejected, though it does not eliminate the possibility of objectionable bias., Competing Interests: BM declares no competing interests. DH declares Co-Investigator status on a funding proposal to the Sloan Foundation, currently in pre-submission stage, to study algorithm-mediated selection processes. The work proposed will use the Entrofy software (publicly available on GitHub) as part of studying how committees engage with algorithmically-mediated decision processes, but is otherwise unrelated to this publication. DH is the only co-author on both this manuscript and the proposal. LN declares employment by Obsidian Security. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Music exhibits structure at multiple scales, ranging from motifs to large-scale functional components. When inferring the structure of a piece, different listeners may attend to different temporal scales, which can result in disagreements when they describe the same piece. In the field of music informatics research (MIR), it is common to use corpora annotated with structural boundaries at different levels. By quantifying disagreements between multiple annotators, previous research has yielded several insights relevant to the study of music cognition. First, annotators tend to agree when structural boundaries are ambiguous. Second, this ambiguity seems to depend on musical features, time scale, and genre. Furthermore, it is possible to tune current annotation evaluation metrics to better align with these perceptual differences. However, previous work has not directly analyzed the effects of hierarchical structure because the existing methods for comparing structural annotations are designed for "flat" descriptions, and do not readily generalize to hierarchical annotations. In this paper, we extend and generalize previous work on the evaluation of hierarchical descriptions of musical structure. We derive an evaluation metric which can compare hierarchical annotations holistically across multiple levels. sing this metric, we investigate inter-annotator agreement on the multilevel annotations of two different music corpora, investigate the influence of acoustic properties on hierarchical annotations, and evaluate existing hierarchical segmentation algorithms against the distribution of inter-annotator agreement.

Recently, many object localization models have shown that incorporating contextual cues can greatly improve accuracy over using appearance features alone. Therefore, many of these models have explored different types of contextual sources, but only considering one level of contextual interaction at the time. Thus, what context could truly contribute to object localization, through integrating cues from all levels, simultaneously, remains an open question. Moreover, the relative importance of the different contextual levels and appearance features across different object classes remains to be explored. Here we introduce a novel framework for multiple class object localization that incorporates different levels of contextual interactions. We study contextual interactions at the pixel, region and object level based upon three different sources of context: semantic, boundary support, and contextual neighborhoods. Our framework learns a single similarity metric from multiple kernels, combining pixel and region interactions with appearance features, and then applies a conditional random field to incorporate object level interactions. To effectively integrate different types of feature descriptions, we extend the large margin nearest neighbor to a novel algorithm that supports multiple kernels. We perform experiments on three challenging image databases: Graz-02, MSRC and PASCAL VOC 2007. Experimental results show that our model outperforms current state-of-the-art contextual frameworks and reveals individual contributions for each contextual interaction level as well as appearance features, indicating their relative importance for object localization.