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This article discusses the incidence and natural history of residual pituitary neuroendocrine tumors (PitNETs) following endoscopic endonasal transsphenoidal surgery (ETSS). The study, conducted at the University of Washington, included 878 patients who underwent ETSS for resection of PitNETs between 2011 and 2023. Of these patients, 12.5% resulted in subtotal resection. The most common locations of residual tumor were the cavernous sinus and suprasellar compartment. Subsequent tumor progression was common, highlighting the need for long-term follow-up in cases of subtotal resection. [Extracted from the article]

This article discusses the clinical and radiographic characteristics, as well as the postoperative outcomes, of a combined endoscopic and transcranial approach for giant pituitary neuroendocrine tumors (PitNETs). The study, conducted at the University of Washington between 2011 and 2022, included 13 patients who underwent the combined approach. The results showed that the combined approach allowed for enhanced visualization and improved working angles, increasing the likelihood of achieving gross total resection. However, residual tumor in the cavernous sinus or adherent to critical neurovascular structures often limited complete resection. Complications of the combined approach included CSF leak, vasospasm, meningitis, hemorrhage, and hydrocephalus. Some patients required readmission within 30 days, and recurrence/progression occurred in a portion of the patients. One patient died due to extensive vasospasm and stroke. Overall, the combined approach shows promise for the resection of giant pituitary adenomas, but further research is needed to optimize outcomes. [Extracted from the article]

This article discusses the surgical outcomes of different types of prolactinomas, including silent, weakly secreting, and functional tumors. The study, conducted at the University of Washington, analyzed data from 282 patients who underwent surgical resection for prolactinomas between 2011 and 2023. The results showed that radiographic gross total resection was achieved in the majority of cases, with higher rates in silent prolactinomas compared to weakly secreting and functional tumors. Biochemical remission of functional prolactinomas occurred at lower rates, indicating the potential need for additional surgical, radiosurgical, or medical therapy. [Extracted from the article]