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1. Twenty-four-hour central (aortic) systolic blood pressure: Reference values and dipping patterns in untreated individuals

Author

Weber, T, Protogerou, A, Agharazii, M, Argyris, A, Bahous, S, Banegas, J, Binder, R, Blacher, J, Brandao, A, Cruz, J, Danninger, K, Giannatasio, C, Graciani, A, Hametner, B, Jankowski, P, Li, Y, Maloberti, A, Mayer, C, Mcdonnell, B, Mceniery, C, Gomes, M, Gomes, A, Muiesan, M, Nemcsik, J, Paini, A, Rodilla, E, Schutte, A, Sfikakis, P, Terentes-Printzios, D, Vallee, A, Vlachopoulos, C, Ware, L, Wilkinson, I, Zweiker, R, Sharman, J, Wassertheurer, S, Weber T., Protogerou A. D., Agharazii M., Argyris A., Bahous S. A., Banegas J. R., Binder R. K., Blacher J., Brandao A. A., Cruz J. J., Danninger K., Giannatasio C., Graciani A., Hametner B., Jankowski P., Li Y., Maloberti A., Mayer C. C., McDonnell B. J., McEniery C. M., Gomes M. A. M., Gomes A. M., Muiesan M. L., Nemcsik J., Paini A., Rodilla E., Schutte A. E., Sfikakis P. P., Terentes-Printzios D., Vallee A., Vlachopoulos C., Ware L., Wilkinson I., Zweiker R., Sharman J. E., Wassertheurer S., Weber, T, Protogerou, A, Agharazii, M, Argyris, A, Bahous, S, Banegas, J, Binder, R, Blacher, J, Brandao, A, Cruz, J, Danninger, K, Giannatasio, C, Graciani, A, Hametner, B, Jankowski, P, Li, Y, Maloberti, A, Mayer, C, Mcdonnell, B, Mceniery, C, Gomes, M, Gomes, A, Muiesan, M, Nemcsik, J, Paini, A, Rodilla, E, Schutte, A, Sfikakis, P, Terentes-Printzios, D, Vallee, A, Vlachopoulos, C, Ware, L, Wilkinson, I, Zweiker, R, Sharman, J, Wassertheurer, S, Weber T., Protogerou A. D., Agharazii M., Argyris A., Bahous S. A., Banegas J. R., Binder R. K., Blacher J., Brandao A. A., Cruz J. J., Danninger K., Giannatasio C., Graciani A., Hametner B., Jankowski P., Li Y., Maloberti A., Mayer C. C., McDonnell B. J., McEniery C. M., Gomes M. A. M., Gomes A. M., Muiesan M. L., Nemcsik J., Paini A., Rodilla E., Schutte A. E., Sfikakis P. P., Terentes-Printzios D., Vallee A., Vlachopoulos C., Ware L., Wilkinson I., Zweiker R., Sharman J. E., and Wassertheurer S.

Abstract

Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18-94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBPMAP/DBPcal), or bSBP/diastolic blood pressure (cSBPSBP/DBPcal), and a validated transfer function, resulting in 144 509 valid brachial and 130 804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBPMAP/DBPcal were 128, 128, and 125 mm Hg and 115, 117, and 107 mm Hg for cSBPSBP/DBPcal, respectively. We pragmatically propose as upper normal limit for 24-hour cSBPMAP/DBPcal 135 mm Hg and for 24-hour cSBPSBP/DBPcal 120 mm Hg. bSBP dipping (nighttimedaytime/ daytime SBP) was -10.6 % in young participants and decreased with increasing age. Central SBPSBP/DBPcal dipping was less pronounced (-8.7% in young participants). In contrast, cSBPMAP/DBPcal dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation.

Published
2022

2. 24-HOUR CENTRAL BLOOD PRESSURE: REFERENCE VALUES FOR HEALTHY INDIVIDUALS. THE INTERNATIONAL 24HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)

Author

Weber, T., Protogerou, A., Wassertheurer, S., Agharazii, M., Argyris, A., Bahous, S.A., Banegas, J.R., Blacher, J., Brandao, A.A., Cruz, J.J., Giannattasio, C., Jankowski, P., Li, Y., Maloberti, A., McDonnel, B., McEniery, C., Gomes, M.A. Mota, Gomes, A. Machado, Graciani, A., Muiesan, M.L., Nemcsik, J., Rodilla, E., Schutte, A., Terentes-Printzios, D., Vallee, A., Vlachopoulos, C., Ware, L., Wilkinson, I., Zweiker, R., and Sharman, J.

Published
2019
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4. RELATIONSHIP BETWEEN 24-HOUR AMBULATORY BRACHIAL VERSUS AORTIC SYSTOLIC BLOOD PRESSURE AND LEFT VENTRICULAR MASS. THE INTERNATIONAL 24 HOUR AORTIC BLOOD PRESSURE CONSORTIUM

Author

Weber, T., Wassertheurer, S., Protogerou, A., Sharman, J., Sala, E. Rodilla, Jankowski, P., Muiesan, M.L., Giannattasio, C., Wilkinson, I., Hametner, B., Pascual, J.M., Zweiker, R., Czarnecka, D., Argyris, A., Paini, A., Salvetti, M., Maloberti, A., Mceniery, C., Li, Y., Nemcsik, J., and Pucci, G.

Published
2018
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19. Validation of non-invasive central blood pressure devices: Artery society task force (abridged) consensus statement on protocol standardization

Author

Sharman, J, Avolio, A, Baulmann, J, Benetos, A, Blacher, J, Blizzard, C, Boutouyrie, P, Chen, C, Chowienczyk, P, Cockcroft, J, Cruickshank, J, Ferreira, I, Ghiadoni, L, Hughes, A, Jankowski, P, Laurent, S, Mcdonnell, B, Mceniery, C, Millasseau, S, Papaioannou, T, Parati, G, Park, J, Protogerou, A, Roman, M, Schillaci, G, Segers, P, Stergiou, G, Tomiyama, H, Townsend, R, Van Bortel, L, Wang, J, Wassertheurer, S, Weber, T, Wilkinson, I, Vlachopoulos, C, Sharman J. E., Avolio A. P., Baulmann J., Benetos A., Blacher J., Blizzard C. L., Boutouyrie P., Chen C. -H., Chowienczyk P., Cockcroft J. R., Cruickshank J. K., Ferreira I., Ghiadoni L., Hughes A., Jankowski P., Laurent S., McDonnell B. J., McEniery C., Millasseau S. C., Papaioannou T. G., Parati G., Park J. B., Protogerou A. D., Roman M. J., Schillaci G., Segers P., Stergiou G. S., Tomiyama H., Townsend R. R., Van Bortel L. M., Wang J., Wassertheurer S., Weber T., Wilkinson I. B., Vlachopoulos C., Sharman, J, Avolio, A, Baulmann, J, Benetos, A, Blacher, J, Blizzard, C, Boutouyrie, P, Chen, C, Chowienczyk, P, Cockcroft, J, Cruickshank, J, Ferreira, I, Ghiadoni, L, Hughes, A, Jankowski, P, Laurent, S, Mcdonnell, B, Mceniery, C, Millasseau, S, Papaioannou, T, Parati, G, Park, J, Protogerou, A, Roman, M, Schillaci, G, Segers, P, Stergiou, G, Tomiyama, H, Townsend, R, Van Bortel, L, Wang, J, Wassertheurer, S, Weber, T, Wilkinson, I, Vlachopoulos, C, Sharman J. E., Avolio A. P., Baulmann J., Benetos A., Blacher J., Blizzard C. L., Boutouyrie P., Chen C. -H., Chowienczyk P., Cockcroft J. R., Cruickshank J. K., Ferreira I., Ghiadoni L., Hughes A., Jankowski P., Laurent S., McDonnell B. J., McEniery C., Millasseau S. C., Papaioannou T. G., Parati G., Park J. B., Protogerou A. D., Roman M. J., Schillaci G., Segers P., Stergiou G. S., Tomiyama H., Townsend R. R., Van Bortel L. M., Wang J., Wassertheurer S., Weber T., Wilkinson I. B., and Vlachopoulos C.

Abstract

Brachial cuff blood pressure (BP) is clinically important, but may be an inaccurate substitute for central BP. Many non-invasive devices have been developed that purport to estimate central BP from peripheral artery sites, yet with no standardized guidelines; the accuracy testing of these new devices has not been undertaken in a uniform fashion with comparable protocols. This is an abridged paper describing the recommendations reached by an international task force convened to identify issues that need to be addressed and reach consensus relating to methods for assessing and reporting the accuracy (validation) of central BP devices. The recommendations are endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society, as well as the European Society of Hypertension (ESH) Working Group on Arterial Structure and Function, and the ESH Working Group on Blood Pressure Monitoring and Cardiovascular Variability. Researchers interested in validating central BP monitors should read the full version of the statement.

Published
2017

20. Relationship Between 24-Hour Ambulatory Central Systolic Blood Pressure and Left Ventricular Mass: A Prospective Multicenter Study

Author

Weber, T, Wassertheurer, S, Schmidt trucksäss, A, Rodilla, E, Ablasser, C, Jankowski, P, Lorenza Muiesan, M, Giannattasio, C, Mang, C, Wilkinson, I, Kellermair, J, Hametner, B, Pascual, J, Zweiker, R, Czarnecka, D, Paini, A, Salvetti, M, Maloberti, A, Mceniery, C, GIANNATTASIO, CRISTINA, MALOBERTI, ALESSANDRO, Mceniery, C., Weber, T, Wassertheurer, S, Schmidt trucksäss, A, Rodilla, E, Ablasser, C, Jankowski, P, Lorenza Muiesan, M, Giannattasio, C, Mang, C, Wilkinson, I, Kellermair, J, Hametner, B, Pascual, J, Zweiker, R, Czarnecka, D, Paini, A, Salvetti, M, Maloberti, A, Mceniery, C, GIANNATTASIO, CRISTINA, MALOBERTI, ALESSANDRO, and Mceniery, C.

Abstract

We investigated the relationship between left ventricular mass and brachial office as well as brachial and central ambulatory systolic blood pressure in 7 European centers. Central systolic pressure was measured with a validated oscillometric device, using a transfer function, and mean/diastolic pressure calibration. M-mode images were obtained by echocardiography, and left ventricular mass was determined by one single reader blinded to blood pressure. We studied 289 participants (137 women) free from antihypertensive drugs (mean age: 50.8 years). Mean office blood pressure was 145/88 mm Hg and mean brachial and central ambulatory systolic pressures were 127 and 128 mm Hg, respectively. Mean left ventricular mass was 93.3 kg/m(2), and 25.6% had left ventricular hypertrophy. The correlation coefficient between left ventricular mass and brachial office, brachial ambulatory, and central ambulatory systolic pressure was 0.29, 0.41, and 0.47, respectively (P=0.003 for comparison between brachial office and central ambulatory systolic pressure and 0.32 for comparison between brachial and central ambulatory systolic pressure). The results were consistent for men and women, and young and old participants. The areas under the curve for prediction of left ventricular hypertrophy were 0.618, 0.635, and 0.666 for brachial office, brachial, and central ambulatory systolic pressure, respectively (P=0.03 for comparison between brachial and central ambulatory systolic pressure). In younger participants, central ambulatory systolic pressure was superior to both other measurements. Central ambulatory systolic pressure, measured with an oscillometric cuff, shows a strong trend toward a closer association with left ventricular mass and hypertrophy than brachial office/ambulatory systolic pressure

Published
2017

23. 24-HOUR CENTRAL BLOOD PRESSURE: REFERENCE VALUES FOR HEALTHY INDIVIDUALS. THE INTERNATIONAL 24HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)

Author

Weber, T. Protogerou, A. Wassertheurer, S. Agharazii, M. and Argyris, A. Bahous, S. A. Banegas, J. R. Blacher, J. and Brandao, A. A. Cruz, J. J. Giannattasio, C. Jankowski, P. and Li, Y. Maloberti, A. McDonnel, B. McEniery, C. Mota Gomes, M. A. Machado Gomes, A. Graciani, A. Muiesan, M. L. and Nemcsik, J. Rodilla, E. Schutte, A. Terentes-Printzios, D. Vallee, A. Vlachopoulos, C. Ware, L. Wilkinson, I. and Zweiker, R. Sharman, J.

Published
2019

27. 24-HOUR CENTRAL BLOOD PRESSURE: REFERENCE VALUES FOR HEALTHY INDIVIDUALS. THE INTERNATIONAL 24HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)

Author

Weber, T, Protogerou, A, Wassertheurer, S, Agharazii, M, Argyris, A, Bahous, S, Banegas, J, Blacher, J, Brandao, A, Cruz, J, Giannattasio, C, Jankowski, P, Li, Y, Maloberti, A, Mcdonnel, B, Mceniery, C, Mota Gomes, M, Machado Gomes, A, Graciani, A, Muiesan, M, Nemcsik, J, Rodilla, E, Schutte, A, Terentes-Printzios, D, Vallee, A, Vlachopoulos, C, Ware, L, Wilkinson, I, Zweiker, R, Sharman., J, T. Weber, A. Protogerou, S. Wassertheurer, M. Agharazii, A. Argyris, S. A. Bahous, J. R. Banegas, J. Blacher, A. A. Brandao, J. J. Cruz, C. Giannattasio, P. Jankowski, Y. Li, A. Maloberti, B. McDonnel, C. McEniery, M. A. Mota Gomes, A. Machado Gomes, A. Graciani, M. L. Muiesan, J. Nemcsik, E. Rodilla, A. Schutte, D. Terentes-Printzios, A. Vallee, C. Vlachopoulos, L. Ware, I. Wilkinson, R. Zweiker, J. Sharman., Weber, T, Protogerou, A, Wassertheurer, S, Agharazii, M, Argyris, A, Bahous, S, Banegas, J, Blacher, J, Brandao, A, Cruz, J, Giannattasio, C, Jankowski, P, Li, Y, Maloberti, A, Mcdonnel, B, Mceniery, C, Mota Gomes, M, Machado Gomes, A, Graciani, A, Muiesan, M, Nemcsik, J, Rodilla, E, Schutte, A, Terentes-Printzios, D, Vallee, A, Vlachopoulos, C, Ware, L, Wilkinson, I, Zweiker, R, Sharman., J, T. Weber, A. Protogerou, S. Wassertheurer, M. Agharazii, A. Argyris, S. A. Bahous, J. R. Banegas, J. Blacher, A. A. Brandao, J. J. Cruz, C. Giannattasio, P. Jankowski, Y. Li, A. Maloberti, B. McDonnel, C. McEniery, M. A. Mota Gomes, A. Machado Gomes, A. Graciani, M. L. Muiesan, J. Nemcsik, E. Rodilla, A. Schutte, D. Terentes-Printzios, A. Vallee, C. Vlachopoulos, L. Ware, I. Wilkinson, R. Zweiker, and J. Sharman.

Published
2019

41. 1.3: Prognostic Value of Carotid-Femoral Pulse Wave Velocity for Cardiovascular Events: An IPD Meta-Analysis of Prospective Observational Data from 14 Studies Including 16,358 Subjects

Author

Ben-Shlomo, Y., Spears, M., Boustred, C., May, M., Anderson, S., Boutouyrie, P., Cameron, J., Chen, C. H., Cockcroft, J. R., Cruickshank, K., Hwang, S. J., Lakatta, E., Laurent, S., Maldonado, J., McEniery, C. M., Mitchell, G., Najjar, S., Newman, A., Ohishi, M., Pannier, B., Pereira, T., Shokawa, T., Sutton-Tyrell, K., Webb, D., Willum-Hansen, T., Zoungas, S., and Wilkinson, I. B.

Published
2011
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42. Isolated systolic hypertension in the young: A position paper endorsed by the European Society of Hypertension

Author

Palatini, P, Agabiti Rosei, E, Avolio, A, Bilo, G, Casiglia, E, Ghiadoni, L, Giannattasio, C, Grassi, G, Jelakovich, B, Julius, S, Mancia, G, Mceniery, C, O’Rourke, M, Parati, G, Pauletto, P, Pucci, G, Saladini, F, Strazzullo, P, Tsioufis, K, Wilkinson, I, Zanchetti, A, McEniery, CM, O’Rourke, MF, Wilkinson, IB, Palatini, P, Agabiti Rosei, E, Avolio, A, Bilo, G, Casiglia, E, Ghiadoni, L, Giannattasio, C, Grassi, G, Jelakovich, B, Julius, S, Mancia, G, Mceniery, C, O’Rourke, M, Parati, G, Pauletto, P, Pucci, G, Saladini, F, Strazzullo, P, Tsioufis, K, Wilkinson, I, Zanchetti, A, McEniery, CM, O’Rourke, MF, and Wilkinson, IB

Abstract

Whether isolated systolic hypertension in the young (ISHY) implies a worse outcome and needs antihypertensive treatment is still a matter for dispute. ISHY is thought to have different mechanisms than systolic hypertension in the elderly. However, findings from previous studies have provided inconsistent results. From the analysis of the literature, two main lines of research and conceptualization have emerged. Simultaneous assessment of peripheral and central blood pressure led to the identification of a condition called pseudo or spurious hypertension, which was considered an innocent condition. However, an increase in pulse wave velocity has been found by some authors in about 20% of the individuals with ISHY. In addition, obesity and metabolic disturbances have often been documented to be associated with ISHY both in children and young adults. The first aspect to consider whenever evaluating a person with ISHY is the possible presence of white-coat hypertension, which has been frequently found in this condition. In addition, assessment of central blood pressure is useful for identifying ISHY patients whose central blood pressure is normal. ISHY is infrequently mentioned in the guidelines on diagnosis and treatment of hypertension. According to the 2013 European Guidelines on the management of hypertension, people with ISHY should be followed carefully, modifying risk factors by lifestyle changes and avoiding antihypertensive drugs. Only future clinical trials will elucidate if a benefit can be achieved with pharmacological treatment in some subgroups of ISHY patients with associated risk factors and/or high central blood pressure.

Published
2018

43. Relationship between 24-hour ambulatory brachial versus aortic systolic blood pressure and left ventricular mass. the international 24 hour aortic blood pressure consortium

Author

Weber, T, Wassertheurer, S, Protogerou, A, Sharman, J, Rodilla Sala, E, Jankowski, P, Muiesan, M, Giannattasio, C, Wilkinson, I, Hametner, B, Pascual, J, Zweiker, R, Czarnecka, D, Argyris, A, Paini, A, Salvetti, M, Maloberti, A, Mceniery, C, Li, Y, Nemcsik, J, Pucci., G, T. Weber, S. Wassertheurer, A. Protogerou, J. Sharman, E. Rodilla Sala, P. Jankowski, M. L. Muiesan, C. Giannattasio, I. Wilkinson, B. Hametner, J. M. Pascual, R. Zweiker, D. Czarnecka, A. Argyris, A. Paini, M. Salvetti, A. Maloberti, C. Mceniery, Y. Li, J. Nemcsik, G. Pucci., Weber, T, Wassertheurer, S, Protogerou, A, Sharman, J, Rodilla Sala, E, Jankowski, P, Muiesan, M, Giannattasio, C, Wilkinson, I, Hametner, B, Pascual, J, Zweiker, R, Czarnecka, D, Argyris, A, Paini, A, Salvetti, M, Maloberti, A, Mceniery, C, Li, Y, Nemcsik, J, Pucci., G, T. Weber, S. Wassertheurer, A. Protogerou, J. Sharman, E. Rodilla Sala, P. Jankowski, M. L. Muiesan, C. Giannattasio, I. Wilkinson, B. Hametner, J. M. Pascual, R. Zweiker, D. Czarnecka, A. Argyris, A. Paini, M. Salvetti, A. Maloberti, C. Mceniery, Y. Li, J. Nemcsik, and G. Pucci.

Published
2018

45. P9.09 Difference in Age-Related Patterns of Arterial Stiffness and Wave Reflections Among Patients with Kidney Disease: Results of the Uk Research Alliance into Kidney Disease and Arterial Stiffness (Ureka) Collaboration

Author

Tomlinson, L. A., Caplin, B., Carr, S. J., Delles, C., Ferro, C. J., Goddard, J., Holt, S. G., Kalra, P. A., Lacy, P. S., McEniery, C. M., McIntyre, C. W., McQuarrie, E. P., Rajkumar, C., Savage, T., Taal, M. W., Tompson, C. R., Townend, J. N., Webb, D. J., Wheeler, D. C., and Wilkinson, I. B.

Published
2010
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