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1. Organophosphate Ester Flame Retardants and Plasticizers in Relation to Fetal Growth in the LIFECODES Fetal Growth Study

Author

Bommarito, Paige A., Stevens, Danielle R., Welch, Barrett M., Ospina, Maria, Calafat, Antonia M., Meeker, John D., Cantonwine, David E., McElrath, Thomas F., and Ferguson, Kelly K.

Subjects
Fireproofing agents -- Environmental aspects -- Health aspects, Fetus -- Growth, Pregnant women -- Health aspects, Environmental issues, Health, Evaluation, Environmental aspects, Health aspects
Abstract

BACKGROUND: Organophosphate esters (OPEs), used ubiquitously as flame retardants and plasticizers in consumer products, are suspected of having developmental toxicity. OBJECTIVES: Our study aimed to estimate associations between prenatal exposure to OPEs and fetal growth, including both ultrasound (head circumference, abdominal circumference, femur length, and estimated fetal weight) and delivery [birth weight z-score, small-for-gestational age (SGA), and large-for-gestational age (LGA)] measures of growth. METHODS: In the LIFECODES Fetal Growth Study (2008-2018), an enriched case--cohort of 900 babies born at the small and large ends of the growth spectrum, we quantified OPE biomarkers in three urine samples per pregnant participant and abstracted ultrasound and delivery measures of fetal growth from medical records. We estimated associations between pregnancy-averaged log-transformed OPE biomarkers and repeated ultrasound measures of fetal growth using linear mixed-effects models, and delivery measures of fetal growth using linear (birth weight) and logistic (SGA and LGA) regression models. RESULTS: Most OPE biomarkers were positively associated with at least one ultrasound measure of fetal growth, but associations with delivery measures were largely null. For example, an interquartile range (IQR; 1.31 ng=mL) increase in bis(2-chloroethyl) phosphate concentration was associated with larger z-scores in head circumference [mean difference (difference): 0.09; 95% confidence interval (CI): 0.01, 0.17], abdominal circumference (difference: 0.10; 95% CI: 0.02, 0.18), femur length (difference: 0.11; 95% CI: 0.03, 0.19), and estimated fetal weight (difference: 0.13; 95% CI: 0.04, 0.22) but not birth weight (difference: 0.04; 95% CI: -0.08, 0.17). At delivery, an IQR (1.00 ng=mL) increase in diphenyl phosphate (DPHP) concentration was associated with an SGA birth (odds ratio: 1.46; 95% CI: 1.10, 1.94). CONCLUSIONS: In a large prospective cohort, gestational OPE exposures were associated with larger fetal size during pregnancy, but associations at delivery were null. DPHP concentrations were associated with heightened risk of an SGA birth. These findings suggest that OPE exposure may affect fetal development. https://doi.org/10.1289/EHP14647, Introduction Organophosphate esters (OPEs) are high-production chemicals in widespread global use. (1) They are organic esters of phosphoric acid--containing alkyl chains or aryl groups, which may be halo-genated or nonhalogenated. [...]

Published
2024
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3. Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts

Author

Welch, Barrett M, Keil, Alexander P, Buckley, Jessie P, Engel, Stephanie M, James-Todd, Tamarra, Zota, Ami R, Alshawabkeh, Akram N, Barrett, Emily S, Bloom, Michael S, Bush, Nicole R, Cordero, José F, Dabelea, Dana, Eskenazi, Brenda, Lanphear, Bruce P, Padmanabhan, Vasantha, Sathyanarayana, Sheela, Swan, Shanna H, Aalborg, Jenny, Baird, Donna D, Binder, Alexandra M, Bradman, Asa, Braun, Joseph M, Calafat, Antonia M, Cantonwine, David E, Christenbury, Kate E, Factor-Litvak, Pam, Harley, Kim G, Hauser, Russ, Herbstman, Julie B, Hertz-Picciotto, Irva, Holland, Nina, Jukic, Anne Marie Z, McElrath, Thomas F, Meeker, John D, Messerlian, Carmen, Michels, Karin B, Newman, Roger B, Nguyen, Ruby HN, O’Brien, Katie M, Rauh, Virginia A, Redmon, Bruce, Rich, David Q, Rosen, Emma M, Schmidt, Rebecca J, Sparks, Amy E, Starling, Anne P, Wang, Christina, Watkins, Deborah J, Weinberg, Clarice R, Weinberger, Barry, Wenzel, Abby G, Wilcox, Allen J, Yolton, Kimberly, Zhang, Yu, and Ferguson, Kelly K

Subjects
Paediatrics, Biomedical and Clinical Sciences, Minority Health, Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Women's Health, Pediatric, Health Disparities, Preterm, Low Birth Weight and Health of the Newborn, Female, Humans, Infant, Newborn, Pregnancy, Biomarkers, Ethnicity, Premature Birth, Maternal Exposure, Phthalic Acids, Racial Groups, Environmental Sciences, Medical and Health Sciences, Toxicology, Biomedical and clinical sciences, Environmental sciences, Health sciences
Abstract

BackgroundPhthalate exposures are ubiquitous during pregnancy and may contribute to racial and ethnic disparities in preterm birth.ObjectivesWe investigated race and ethnicity in the relationship between biomarkers of phthalate exposure and preterm birth by examining: a) how hypothetical reductions in racial and ethnic disparities in phthalate metabolites might reduce the probability of preterm birth; and b) exposure-response models stratified by race and ethnicity.MethodsWe pooled individual-level data on 6,045 pregnancies from 16 U.S. cohorts. We investigated covariate-adjusted differences in nine urinary phthalate metabolite concentrations by race and ethnicity [non-Hispanic White (White, 43%), non-Hispanic Black (Black, 13%), Hispanic/Latina (38%), and Asian/Pacific Islander (3%)]. Using g-computation, we estimated changes in the probability of preterm birth under hypothetical interventions to eliminate disparities in levels of urinary phthalate metabolites by proportionally lowering average concentrations in Black and Hispanic/Latina participants to be approximately equal to the averages in White participants. We also used race and ethnicity-stratified logistic regression to characterize associations between phthalate metabolites and preterm birth.ResultsIn comparison with concentrations among White participants, adjusted mean phthalate metabolite concentrations were consistently higher among Black and Hispanic/Latina participants by 23%-148% and 4%-94%, respectively. Asian/Pacific Islander participants had metabolite levels that were similar to those of White participants. Hypothetical interventions to reduce disparities in metabolite mixtures were associated with lower probabilities of preterm birth for Black [13% relative reduction; 95% confidence interval (CI): -34%, 8.6%] and Hispanic/Latina (9% relative reduction; 95% CI: -19%, 0.8%) participants. Odds ratios for preterm birth in association with phthalate metabolites demonstrated heterogeneity by race and ethnicity for two individual metabolites (mono-n-butyl and monoisobutyl phthalate), with positive associations that were larger in magnitude observed among Black or Hispanic/Latina participants.ConclusionsPhthalate metabolite concentrations differed substantially by race and ethnicity. Our results show hypothetical interventions to reduce population-level racial and ethnic disparities in biomarkers of phthalate exposure could potentially reduce the probability of preterm birth. https://doi.org/10.1289/EHP12831.

Published
2023

9. Urinary phthalate metabolite mixtures in pregnancy and fetal growth: Findings from the infant development and the environment study

Author

Stevens, Danielle R, Bommarito, Paige A, Keil, Alexander P, McElrath, Thomas F, Trasande, Leonardo, Barrett, Emily S, Bush, Nicole R, Nguyen, Ruby HN, Sathyanarayana, Sheela, Swan, Shanna, and Ferguson, Kelly K

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Prevention, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Clinical Research, Conditions Affecting the Embryonic and Fetal Periods, Reproductive health and childbirth, Birth Weight, Child Development, Female, Fetal Development, Humans, Male, Maternal Exposure, Phthalic Acids, Pregnancy, Prospective Studies, Phthalic acid, Birth weight, Endocrine disruptors, Fetal weight, Fish oils, Fatty acids, omega-3, Prospective studies, Fatty acids, omega-3, Environmental Sciences
Abstract

BackgroundPrenatal phthalate exposure has been linked to reductions in fetal growth in animal and laboratory studies, but epidemiologic evidence is equivocal.ObjectiveExamine the association between prenatal phthalate metabolite mixtures and fetal growth and evaluate whether that association is modified by fetal sex or omega-3 intake during pregnancy.MethodsAnalyses included 604 singleton pregnancies from TIDES, a prospective pregnancy cohort with spot urine samples and questionnaires collected in each trimester. Pregnancy-averaged phthalate exposure estimates were calculated as the geometric means of specific-gravity corrected phthalate metabolites. Fetal growth outcomes included birthweight and length, and ultrasound-derived size and velocity of estimated fetal weight, femur length, abdominal and head circumferences in the second and third trimesters. We used a novel application of quantile g-computation to estimate the joint association between pregnancy-averaged phthalate exposure and fetal growth, and to examine effect modification of that association by infant sex or omega-3 intake during pregnancy.ResultsThere were few statistically significant differences in birth size and fetal growth by exposure. A one-quartile increase in the phthalate mixture was modestly associated with reduced birthweight(β [95% confidence interval)]: -54.6 [-128.9, 19.7] grams; p = 0.15) and length (-0.2 [-0.6, 0.2] centimeters; p = 0.40). A one-quartile increase in the phthalate mixture was associated with reduced birth length in males (-0.5 [-1.0, 0.0] centimeters) but not for females (0.1 [-0.2, 0.3] centimeters); interaction p = 0.05. The phthalate metabolite mixture was inversely associated with ultrasound-derived fetal growth among those with adequate omega-3 intake. For example, a one-quartile increase in the phthalate mixture was associated with reduced abdominal circumference in the third trimesters in those with adequate omega-3 intake (-3.3 [-6.8, 0.1] millimeters) but not those with inadequate omega-3 intake (1.8 [-0.8, 4.5] millimeters); interaction p = 0.01.ConclusionPrenatal phthalate exposure was not significantly associated with fetal growth outcomes, with some exceptions for certain subgroups.

Published
2022

10. Prenatal Phthalate Exposure and Child Weight and Adiposity from in Utero to 6 Years of Age

Author

Ferguson, Kelly K, Bommarito, Paige A, Arogbokun, Olufunmilayo, Rosen, Emma M, Keil, Alexander P, Zhao, Shanshan, Barrett, Emily S, Nguyen, Ruby HN, Bush, Nicole R, Trasande, Leonardo, McElrath, Thomas F, Swan, Shanna H, and Sathyanarayana, Sheela

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Prevention, Obesity, Pediatric Research Initiative, Conditions Affecting the Embryonic and Fetal Periods, Perinatal Period - Conditions Originating in Perinatal Period, Nutrition, Pediatric, Clinical Research, Reproductive health and childbirth, Adiposity, Adult, Birth Weight, Child, Environmental Exposure, Environmental Pollutants, Female, Humans, Infant, Infant, Newborn, Phthalic Acids, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Environmental Sciences, Medical and Health Sciences, Toxicology, Biomedical and clinical sciences, Environmental sciences, Health sciences
Abstract

BackgroundPrenatal phthalate exposure has been associated with lower birth weight but also higher weight in childhood. Few studies have examined weight or adiposity from birth to childhood and thus cannot assess growth trajectories associated with exposure.ObjectiveWe assessed associations between maternal phthalate exposures in pregnancy and child weight and adiposity measured prenatally through childhood (3-6 years of age).MethodsWithin The Infant Development and the Environment Study (TIDES), a prospective pregnancy cohort, we analyzed a panel of phthalate metabolites in urine collected at two visits from early and late gestation (N=780). We estimated average phthalate metabolite associations with child weight z-scores from ∼20wk gestation (estimated by ultrasound), birth, and 1, 3, 4, and 6 years of age using linear mixed-effects (LME) models. We also modeled associations with adiposity z-scores from birth (weight for length) and 1, 3, 4, and 6 years of age [body mass index (BMI)] using LME models.ResultsFor weight, we observed inverse associations between several phthalate metabolites and birth weight z-scores, but no associations were observed with postnatal weight z-scores in LME models. Regarding adiposity, we observed inverse associations between phthalate metabolites and weight-for-length z-scores at birth, but positive associations were observed with BMI z-scores at 3-4 years of age in LME models. For example, mono-ethyl phthalate was associated with a 0.17-unit decrease in birth weight-for-length z-score [95% confidence interval (CI): -0.29, -0.05] and a 0.18-unit increase in 4-years-of-age BMI z-score (95% CI: 0.04, 0.32).DiscussionWe observed associations between prenatal exposure to phthalates and lower weight at birth but not at childhood follow-up visits. However, for adiposity, we observed an interesting pattern of association with low adiposity at delivery as well as high adiposity at 3-4 years of age. Although it is not clear from our results whether these associations occur within the same children, such a pattern of adiposity in early life has been linked to cardiometabolic disease in adulthood and deserves special attention as an outcome in the study of prenatal exposures in the developmental origins of health and disease. https://doi.org/10.1289/EHP10077.

Published
2022

11. Use of B-Cell–Depleting Therapy in Women of Childbearing Potential With Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

Author

Galati, Alexandra, McElrath, Thomas, and Bove, Riley

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Biotechnology, Prevention, Brain Disorders, Contraception/Reproduction, Reproductive health and childbirth, Neurosciences
Abstract

Purpose of reviewThere is considerable heterogeneity in the use of B-cell depletion in women of childbearing age, likely driven at least in part by the discrepancy between the product labels and what is known about the physiology of IgG1, including breastmilk and placental transfer.Recent findingsWe provide practical considerations on the use of this medication class in women of childbearing potential. We discuss prepregnancy planning including vaccinations, safety of B-cell depletion during pregnancy, and postpartum considerations including breastfeeding.SummaryB-cell-depleting monoclonal antibodies have shown to be effective for prepregnancy and postpartum prevention of inflammatory activity in MS and neuromyelitis optica spectrum disorder. B-cell-depleting therapies are large IgG1 monoclonal antibodies, which have minimal transfer across the placenta and into breastmilk. Consideration of risks and benefits of these therapies should be considered in counseling women planning pregnancy and postpartum.

Published
2022

13. A Hierarchical Integrative Group LASSO (HiGLASSO) Framework for Analyzing Environmental Mixtures

Author

Boss, Jonathan, Rix, Alexander, Chen, Yin-Hsiu, Narisetty, Naveen N., Wu, Zhenke, Ferguson, Kelly K., McElrath, Thomas F., Meeker, John D., and Mukherjee, Bhramar

Subjects
Statistics - Methodology, Statistics - Applications
Abstract

Environmental health studies are increasingly measuring multiple pollutants to characterize the joint health effects attributable to exposure mixtures. However, the underlying dose-response relationship between toxicants and health outcomes of interest may be highly nonlinear, with possible nonlinear interaction effects. Existing penalized regression methods that account for exposure interactions either cannot accommodate nonlinear interactions while maintaining strong heredity or are computationally unstable in applications with limited sample size. In this paper, we propose a general shrinkage and selection framework to identify noteworthy nonlinear main and interaction effects among a set of exposures. We design hierarchical integrative group LASSO (HiGLASSO) to (a) impose strong heredity constraints on two-way interaction effects (hierarchical), (b) incorporate adaptive weights without necessitating initial coefficient estimates (integrative), and (c) induce sparsity for variable selection while respecting group structure (group LASSO). We prove sparsistency of the proposed method and apply HiGLASSO to an environmental toxicants dataset from the LIFECODES birth cohort, where the investigators are interested in understanding the joint effects of 21 urinary toxicant biomarkers on urinary 8-isoprostane, a measure of oxidative stress. An implementation of HiGLASSO is available in the higlasso R package, accessible through the Comprehensive R Archive Network., Comment: 29 pages, 6 figures

Published
2020
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16. First- and Third-Trimester Urinary Phthalate Metabolites in the Development of Hypertensive Diseases of Pregnancy

Author

Bedell, Sabrina M, Lyden, Grace R, Sathyanarayana, Sheela, Barrett, Emily S, Ferguson, Kelly K, Santilli, Ashley, Bush, Nicole R, Swan, Shanna H, McElrath, Thomas F, and Nguyen, Ruby HN

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Cardiovascular, Hypertension, Pediatric, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Reproductive health and childbirth, Child, Environmental Pollutants, Female, Humans, Phthalic Acids, Pregnancy, Pregnancy Trimester, Third, Prospective Studies, phthalates, hypertension, pregnancy, blood pressure, preeclampsia, Toxicology
Abstract

The purpose of this study was to determine whether maternal urinary phthalate metabolite concentrations are associated with the development of higher blood pressure or pregnancy-induced hypertension (PIH). Participants were women without chronic hypertension who enrolled in The Infant Development and the Environment Study, a prospective pregnancy cohort conducted at four U.S. academic medical centers from 2010-2012. Prenatal records were reviewed to obtain blood pressure measurements and diagnoses of PIH (gestational hypertension, preeclampsia, eclampsia, and HELLP syndrome, defined as hemolysis, elevated liver enzymes, and low platelet count). Complete-case analyses used multivariable linear and logistic regression for analysis of blood pressure measurements and PIH diagnoses, respectively. In the final dataset (N = 668), higher concentrations of first-trimester monoethyl phthalate (MEP) and mono-3-carboxypropyl phthalate (MCPP) and third-trimester mono-isobutyl phthalate (MiBP) were significantly associated with a medical chart diagnosis of PIH. First-trimester mono-n-butyl phthalate (MBP) and MEP along with the sum of di-(2-ethylhexyl) phthalate metabolites (∑DEHP) were each associated with increased systolic blood pressure across pregnancy. In conclusion, several phthalate metabolite concentrations were significantly associated with PIH and greater increases in systolic blood pressure across pregnancy.

Published
2021

17. Joint impact of phthalate exposure and stressful life events in pregnancy on preterm birth

Author

Ferguson, Kelly K, Rosen, Emma M, Barrett, Emily S, Nguyen, Ruby HN, Bush, Nicole, McElrath, Thomas F, Swan, Shanna H, and Sathyanarayana, Sheela

Subjects
Perinatal Period - Conditions Originating in Perinatal Period, Mental Health, Clinical Research, Pediatric, 2.2 Factors relating to the physical environment, Aetiology, Reproductive health and childbirth, Good Health and Well Being, Adult, Female, Humans, Infant, Newborn, Male, Maternal Exposure, Phthalic Acids, Pregnancy, Pregnancy Trimesters, Premature Birth, Prospective Studies, Socioeconomic Factors, Stress, Psychological, Surveys and Questionnaires, United States, Young Adult, Phthalates, Preterm birth, Gestational age, Stress, Psychological, Environmental Sciences
Abstract

BackgroundUrinary phthalate metabolites and psychosocial stress in pregnancy have each been associated with preterm birth (PTB), but no study has examined the joint impact of these two environmental exposures. We hypothesized that there would be stronger associations between phthalate exposure and PTB in mothers with higher stress in pregnancy compared to mothers with lower stress.MethodsWe addressed this question using data from The Infant Development and the Environment Study (TIDES), a prospective birth cohort conducted at four US sites (N = 783). We examined urinary phthalate metabolite concentrations measured in samples collected from up to three trimesters of pregnancy. Mothers reported their exposure to stressful life events (SLE) in each trimester in a questionnaire administered in the third trimester. PTB was defined as delivery before 37 weeks completed gestation (n = 71, 9.1%). We examined associations between urinary phthalate metabolite concentrations (individual time points and on average) and PTB using logistic regression models adjusted for maternal race, age, pre-pregnancy body mass index, education, specific gravity, and gestational age at sample collection. In addition, we created models stratified by whether or not mothers were exposed to any or no SLE in pregnancy.ResultsSummed di-2-ethylhexyl phthalate (ΣDEHP) metabolites measured in urine samples from the third trimester, but not the first trimester, were associated with an increased odds ratio (OR) of PTB (OR = 1.44, 95% confidence interval [CI] = 1.06, 1.95). In models stratified by SLE, associations between third trimester ΣDEHP concentrations and PTB were significant only for women experiencing one or more SLE during pregnancy (OR for ΣDEHP: 2.09, 95% CI: 1.29, 3.37) but not for women with no SLE during pregnancy (OR for ΣDEHP: 1.04, 95% CI: 0.66, 1.63) (p for interaction = 0.07).ConclusionsWe observed an association between urinary ΣDEHP levels and PTB that was modified by whether a mother was exposed to one or more psychosocial stressors during pregnancy. Additional research to understand the joint impacts of chemical and non-chemical exposures, with an emphasis on timing of exposure, is needed in order to advance the state of the science on how the environment influences pregnancy.

Published
2019

19. Maternal urinary phthalate metabolites in relation to gestational diabetes and glucose intolerance during pregnancy

Author

Shaffer, Rachel M, Ferguson, Kelly K, Sheppard, Lianne, James-Todd, Tamarra, Butts, Samantha, Chandrasekaran, Suchitra, Swan, Shanna H, Barrett, Emily S, Nguyen, Ruby, Bush, Nicole, McElrath, Thomas F, Sathyanarayana, Sheela, and team, the TIDES Study

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Clinical Research, Conditions Affecting the Embryonic and Fetal Periods, Diabetes, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Reproductive health and childbirth, Good Health and Well Being, Adult, Blood Glucose, Body Mass Index, Diabetes, Gestational, Female, Glucose Intolerance, Humans, Linear Models, Logistic Models, Phthalic Acids, Pregnancy, Pregnancy Trimester, First, Pregnancy Trimester, Third, Young Adult, Gestational diabetes, Impaired glucose intolerance, Blood glucose, Phthalates, Endocrine disruptors, TIDES Study team, Environmental Sciences
Abstract

BackgroundPhthalates are common plasticizer chemicals that have been linked to glucose intolerance in the general population, but there is only limited research on their association with gestational diabetes (GDM).ObjectiveWe evaluated the association between 11 urinary phthalate metabolites and GDM, impaired glucose tolerance (IGT), and continuous blood glucose concentration during pregnancy in The Infant Development and Environment Study (TIDES). Based on prior study results, our primary analyses focused on monoethyl phthalate (MEP) in relation to our outcomes of interest.Study designWe used multi-variable logistic regression to examine the odds of GDM and IGT in relation to an interquartile-range (IQR) increase in natural log (ln)-transformed, specific gravity (SG)-adjusted first trimester (T1) and average of T1 and third trimester (T3) ("T1T3avg") phthalate metabolite concentrations. We fit linear regression models to examine the percent change in blood glucose per IQR increase in ln-transformed, SG-adjusted T1 and T1T3avg phthalates. In sensitivity analyses, we examined interactions between exposure and race. We adjusted for maternal age, maternal body mass index, study center, race/ethnicity, parity, and gestational age at glucose testing.ResultsIn our sample of 705 pregnant women, we observed 60 cases of GDM, 90 cases of IGT, and an average GLT blood glucose of 113.6 ± 27.7 mg/dL. In our primary analysis, T1T3avg MEP was positively associated with GDM ([OR (95% CI) per IQR increase] T1T3avg MEP: 1.61 (1.10, 2.36)). In secondary analyses, most other phthalates were not found to be related to study outcomes, though some associations were noted. Sensitivity analyses indicated possible strong race-specific associations in Asians, though these results are based on a small sample size (n = 35).ConclusionIn alignment with our a priori selection, we documented an association between T1T3avg MEP and GDM. Additional phthalate metabolites were also found to be linked to glucose intolerance, with possible stronger associations in certain racial/ethnic subgroups. Given the prevalence of phthalate exposures and the growing evidence of associations with metabolic outcomes, future studies should continue to examine this question in diverse cohorts of pregnant women, particularly in those who may be at higher risk for GDM and IGT.

Published
2019

20. Urinary oxidative stress biomarkers and accelerated time to spontaneous delivery

Author

Rosen, Emma M, van 't Erve, Thomas J, Boss, Jonathan, Sathyanarayana, Sheela, Barrett, Emily S, Nguyen, Ruby HN, Bush, Nicole R, Milne, Ginger L, McElrath, Thomas F, Swan, Shanna H, and Ferguson, Kelly K

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Clinical Research, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Infant Mortality, Preterm, Low Birth Weight and Health of the Newborn, Reproductive health and childbirth, Adult, Biomarkers, Dinoprost, Female, Humans, Infant, Newborn, Lipid Peroxidation, Oxidative Stress, Pregnancy, Pregnancy Trimester, Third, Premature Birth, Oxidative stress, Isoprostanes, Prostaglandin, Preterm birth, Spontaneous labor, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medical biochemistry and metabolomics
Abstract

BackgroundOxidative stress has been implicated in numerous birth outcomes, including spontaneous preterm birth. However, the relationship with presentation at delivery has been less well studied. We assessed the relationship between oxidative stress biomarkers and gestational duration with a focus on spontaneous presentation for delivery.MethodsOur sample included 740 women from a multi-center prospective cohort study, recruited from 2010 to 2012. Resultant measures of oxidative stress in pregnancy prostaglandin F2α (PGF2α), 8-iso-prostaglandin F2α (8-iso-PGF2α), and the primary 8-iso-PGF2α metabolite were measured in third trimester urine samples. Information on presentation for delivery was abstracted from medical records. We examined associations with preterm birth using adjusted logistic models. Time to event (overall delivery and spontaneous delivery) was examined using adjusted accelerated failure time models.ResultsThe 8-iso-PGF2α metabolite was associated with increased odds of overall preterm birth (OR: 1.44 [95% CI: 1.00, 2.06]), and the association with spontaneous preterm birth was similar in magnitude but not statistically significant (OR: 1.45 [95% CI: 0.96, 2.20]). We did not detect associations between other biomarkers and preterm birth, or between biomarkers and timing of overall or spontaneous delivery in accelerated failure time models.ConclusionsOur data suggest that increased oxidative stress, as indicated by the 8-iso-PGF2α metabolite, may be associated with preterm birth. In contrast to previous studies, associations were similar among individuals with spontaneous versus non-spontaneous presentation for delivery.

Published
2019

24. RNA profiles reveal signatures of future health and disease in pregnancy

Author

Rasmussen, Morten, Reddy, Mitsu, Nolan, Rory, Camunas-Soler, Joan, Khodursky, Arkady, Scheller, Nikolai M., Cantonwine, David E., Engelbrechtsen, Line, Mi, Jia Dai, Dutta, Arup, Brundage, Tiffany, Siddiqui, Farooq, Thao, Mainou, Gee, Elaine P. S., La, Johnny, Baruch-Gravett, Courtney, Santillan, Mark K., Deb, Saikat, Ame, Shaali M., Ali, Said M., Adkins, Melanie, DePristo, Mark A., Lee, Manfred, Namsaraev, Eugeni, Gybel-Brask, Dorte Jensen, Skibsted, Lillian, Litch, James A., Santillan, Donna A., Sazawal, Sunil, Tribe, Rachel M., Roberts, James M., Jain, Maneesh, Høgdall, Estrid, Holzman, Claudia, Quake, Stephen R., Elovitz, Michal A., and McElrath, Thomas F.

Published
2022
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25. Cohort profile: the Environmental Reproductive and Glucose Outcomes (ERGO) Study (Boston, Massachusetts, USA) — a prospective pregnancy cohort study of the impacts of environmental exposures on parental cardiometabolic health

Author

Preston, Emma V, primary, Quinn, Marlee R, additional, Williams, Paige L, additional, McElrath, Thomas F, additional, Cantonwine, David E, additional, Seely, Ellen W, additional, Wylie, Blair J, additional, Hacker, Michele R, additional, O'Brien, Karen, additional, Brown, Florence M, additional, Powe, Camille E, additional, Bellavia, Andrea, additional, Wang, Zifan, additional, Tomsho, Kathryn S, additional, Hauser, Russ, additional, and James-Todd, Tamarra, additional

Published
2024
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26. Pregnancy and Infant Outcomes in Females Receiving Ocrelizumab for the Treatment of Multiple Sclerosis: Analysis of over 3,000 Pregnancies to Date (S7.004)

Author

Bove, Riley, primary, Pietrasanta, Carlo, additional, Oreja-Guevara, Celia, additional, Hellwig, Kerstin, additional, Dobson, Ruth, additional, Vukusic, Sandra, additional, Lin, Chien-Ju, additional, Alvarez, Daniela Goncalves Pereira, additional, Zecevic, Dusanka, additional, Ferreira, Germano, additional, Craveiro, Licinio, additional, Pasquarelli, Noemi, additional, and McElrath, Thomas, additional

Published
2024
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29. Neonatal Outcomes in the MONEAD Study of Pregnant Women with Epilepsy

Author

Bagic, Anto, Barkley, Gregory, Cavitt, Jennifer, DeWolfe, Jennifer, French, Jacqueline, Gedzelman, Evan, Gerard, Elizabeth, Hwang, Sean, Kalayjian, Laura, Krauss, Gregory, Labiner, David, McCabe, Paul, Miller, John, Pack, Alison, Penovich, Patricia, Sam, Maria, Serrano, Enrique, Strickland, Suzanne, Van Marter, Linda J., Pennell, Page B., Brown, Carrie, Hartman, Adam L., May, Ryan C., McElrath, Thomas, Ippolito, Dominic, and Meador, Kimford J.

Published
2021
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30. Catálogo Taxonômico da Fauna do Brasil: setting the baseline knowledge on the animal diversity in Brazil

Author

Boeger, Walter A, Valim, Michel P, Zaher, Hussam, Rafael, José A, Forzza, Rafaela C, Percequillo, Alexandre R, Serejo, Cristiana S, Garraffoni, André RS, Santos, Adalberto J, Slipinski, Adam, Linzmeier, Adelita M, Calor, Adolfo R, Garda, Adrian A, Kury, Adriano B, Fernandes, Agatha CS, Agudo-Padrón, Aisur I, Akama, Alberto, Silva Neto, Alberto M da, Burbano, Alejandro L, Menezes, Aleksandra, Pereira-Colavite, Alessandre, Anichtchenko, Alexander, Lees, Alexander C, Bezerra, Alexandra MR, Domahovski, Alexandre C, Pimenta, Alexandre D, Aleixo, Alexandre LP, Marceniuk, Alexandre P, Paula, Alexandre S de, Somavilla, Alexandre, Specht, Alexandre, Camargo, Alexssandro, Newton, Alfred F, Silva, Aline AS da, Santos, Aline B dos, Tassi, Aline D, Aragão, Allan C, Santos, Allan PM, Migotto, Alvaro E, Mendes, Amanda C, Cunha, Amanda, Chagas Júnior, Amazonas, Sousa, Ana AT de, Pavan, Ana C, Almeida, Ana CS, Peronti, Ana LBG, Henriques-Oliveira, Ana L, Prudente, Ana L, Tourinho, Ana L, Pes, Ana MO, Carmignotto, Ana P, Wengrat, Ana PG da Silva, Dornellas, Ana PS, Molin, Anamaria Dal, Puker, Anderson, Morandini, André C, Ferreira, André da S, Martins, André L, Esteves, André M, Fernandes, André S, Roza, André S, Köhler, Andreas, Paladini, Andressa, Andrade, Andrey J de, Pinto, Ângelo P, Salles, Anna C de A, Gondim, Anne I, Amaral, Antonia CZ, Rondón, Antonio AA, Brescovit, Antonio, Lofego, Antônio C, Marques, Antonio C, Macedo, Antonio, Andriolo, Artur, Henriques, Augusto L, Ferreira Júnior, Augusto L, Lima, Aurino F de, Barros, Ávyla R de A, Brito, Ayrton do R, Romera, Bárbara LV, Vasconcelos, Beatriz MC de, Frable, Benjamin W, Santos, Bernardo F, Ferraz, Bernardo R, Rosa, Brunno B, Sampaio, Brunno HL, Bellini, Bruno C, Clarkson, Bruno, Oliveira, Bruno G de, Corrêa, Caio CD, Martins, Caleb C, Castro-Guedes, Camila F de, Souto, Camilla, Bicho, Carla de L, Cunha, Carlo M, Barboza, Carlos A de M, Lucena, Carlos AS de, Barreto, Carlos, Santana, Carlos DCM de, Agne, Carlos EQ, Mielke, Carlos GC, Caetano, Carlos HS, Flechtmann, Carlos HW, Lamas, Carlos JE, Rocha, Carlos, Mascarenhas, Carolina S, Margaría, Cecilia B, Waichert, Cecilia, Digiani, Celina, Haddad, Célio FB, Azevedo, Celso O, Benetti, Cesar J, Santos, Charles MD dos, Bartlett, Charles R, Bonvicino, Cibele, Ribeiro-Costa, Cibele S, Santos, Cinthya SG, Justino, Cíntia EL, Canedo, Clarissa, Bonecker, Claudia C, Santos, Cláudia P, Carvalho, Claudio JB de, Gonçalves, Clayton C, Galvão, Cleber, Costa, Cleide, Oliveira, Cléo DC de, Schwertner, Cristiano F, Andrade, Cristiano L, Pereira, Cristiano M, Sampaio, Cristiano, Dias, Cristina de O, Lucena, Daercio A de A, Manfio, Daiara, Amorim, Dalton de S, Queiroz, Dalva L de, Colpani, Daniara, Abbate, Daniel, Aquino, Daniel A, Burckhardt, Daniel, Cavallari, Daniel C, Prado, Daniel de C Schelesky, Praciano, Daniel L, Basílio, Daniel S, Bená, Daniela de C, Toledo, Daniela GP de, Takiya, Daniela M, Fernandes, Daniell RR, Ament, Danilo C, Cordeiro, Danilo P, Silva, Darliane E, Pollock, Darren A, Muniz, David B, Gibson, David I, Nogueira, David S, Marques, Dayse WA, Lucatelli, Débora, Garcia, Deivys MA, Baêta, Délio, Ferreira, Denise NM, Rueda-Ramírez, Diana, Fachin, Diego A, Souza, Diego de S, Rodrigues, Diego F, Pádua, Diego G de, Barbosa, Diego N, Dolibaina, Diego R, Amaral, Diogo C, Chandler, Donald S, Maccagnan, Douglas HB, Caron, Edilson, Carvalho, Edrielly, Adriano, Edson A, Abreu Júnior, Edson F de, Pereira, Edson HL, Viegas, Eduarda FG, Carneiro, Eduardo, Colley, Eduardo, Eizirik, Eduardo, Santos, Eduardo F dos, Shimbori, Eduardo M, Suárez-Morales, Eduardo, Arruda, Eliane P de, Chiquito, Elisandra A, Lima, Élison FB, Castro, Elizeu B de, Orlandin, Elton, Nascimento, Elynton A do, Razzolini, Emanuel, Gama, Emanuel RR, Araujo, Enilma M de, Nishiyama, Eric Y, Spiessberger, Erich L, Santos, Érika CL dos, Contreras, Eugenia F, Galati, Eunice AB, Oliveira Junior, Evaldo C de, Gallardo, Fabiana, Hernandes, Fabio A, Lansac-Tôha, Fábio A, Pitombo, Fabio B, Dario, Fabio Di, Santos, Fábio L dos, Mauro, Fabio, Nascimento, Fabio O do, Olmos, Fabio, Amaral, Fabio R, Schunck, Fabio, Godoi, Fábio SP de, Machado, Fabrizio M, Barbo, Fausto E, Agrain, Federico A, Ribeiro, Felipe B, Moreira, Felipe FF, Barbosa, Felipe F, Silva, Fenanda S, Cavalcanti, Fernanda F, Straube, Fernando C, Carbayo, Fernando, Carvalho Filho, Fernando, Zanella, Fernando CV, Jacinavicius, Fernando de C, Farache, Fernando HA, Leivas, Fernando, Dias, Fernando MS, Mantellato, Fernando, Vaz-de-Mello, Fernando Z, Gudin, Filipe M, Albuquerque, Flávio, Molina, Flavio B, Passos, Flávio D, Shockley, Floyd W, Pinheiro, Francielly F, Mello, Francisco de AG de, Nascimento, Francisco E de L, Franco, Francisco L, Oliveira, Francisco L de, Melo, Francisco T de V, Quijano, Freddy RB, Salles, Frederico F, Biffi, Gabriel, Queiroz, Gabriel C, Bizarro, Gabriel L, Hrycyna, Gabriela, Leviski, Gabriela, Powell, Gareth S, Santos, Geane B dos, Morse, Geoffrey E, Brown, George, Mattox, George MT, Zimbrão, Geraldo, Carvalho, Gervásio S, Miranda, Gil FG, Moraes, Gilberto J de, Lourido, Gilcélia M, Neves, Gilmar P, Moreira, Gilson RP, Montingelli, Giovanna G, Maurício, Giovanni N, Marconato, Gláucia, Lopez, Guilherme EL, Silva, Guilherme L da, Muricy, Guilherme, Brito, Guilherme RR, Garbino, Guilherme ST, Flores, Gustavo E, Graciolli, Gustavo, Libardi, Gustavo S, Proctor, Heather C, Gil-Santana, Helcio R, Varella, Henrique R, Escalona, Hermes E, Schmitz, Hermes J, Rodrigues, Higor DD, Galvão Filho, Hilton de C, Quintino, Hingrid YS, Pinto, Hudson A, Rainho, Hugo L, Miyahira, Igor C, Gonçalves, Igor de S, Martins, Inês X, Cardoso, Irene A, Oliveira, Ismael B de, Franz, Ismael, Fernandes, Itanna O, Golfetti, Ivan F, S. Campos-Filho, Ivanklin, Oliveira, Ivo de S, Delabie, Jacques HC, Oliveira, Jader de, Prando, Jadila S, Patton, James L, Bitencourt, Jamille de A, Silva, Janaina M, Santos, Jandir C, Arruda, Janine O, Valderrama, Jefferson S, Dalapicolla, Jeronymo, Oliveira, Jéssica P, Hájek, Jiri, Morselli, João P, Narita, João P, Martin, João PI, Grazia, Jocélia, McHugh, Joe, Cherem, Jorge J, Farias Júnior, José AS, Fernandes, Jose AM, Pacheco, José F, Birindelli, José LO, Rezende, José M, Avendaño, Jose M, Duarte, José M Barbanti, Ribeiro, José R Inácio, Mermudes, José RM, Pujol-Luz, José R, Santos, Josenilson R dos, Câmara, Josenir T, Teixeira, Joyce A, Prado, Joyce R do, Botero, Juan P, Almeida, Julia C, Kohler, Julia, Gonçalves, Julia P, Beneti, Julia S, Donahue, Julian P, Alvim, Juliana, Almeida, Juliana C, Segadilha, Juliana L, Wingert, Juliana M, Barbosa, Julianna F, Ferrer, Juliano, Santos, Juliano F dos, Kuabara, Kamila MD, Nascimento, Karine B, Schoeninger, Karine, Campião, Karla M, Soares, Karla, Zilch, Kássia, Barão, Kim R, Teixeira, Larissa, Sousa, Laura D do NM de, Dumas, Leandro L, Vieira, Leandro M, Azevedo, Leonardo HG, Carvalho, Leonardo S, Souza, Leonardo S de, Rocha, Leonardo SG, Bernardi, Leopoldo FO, Vieira, Letícia M, Johann, Liana, Salvatierra, Lidianne, Oliveira, Livia de M, Loureiro, Lourdes MA El-moor, Barreto, Luana B, Barros, Luana M, Lecci, Lucas, Camargos, Lucas M de, Lima, Lucas RC, Almeida, Lucia M, Martins, Luciana R, Marinoni, Luciane, Moura, Luciano de A, Lima, Luciano, Naka, Luciano N, Miranda, Lucília S, Salik, Lucy M, Bezerra, Luis EA, Silveira, Luis F, Campos, Luiz A, Castro, Luiz AS de, Pinho, Luiz C, Silveira, Luiz FL, Iniesta, Luiz FM, Tencatt, Luiz FC, Simone, Luiz RL, Malabarba, Luiz R, Cruz, Luiza S da, Sekerka, Lukas, Barros, Lurdiana D, Santos, Luziany Q, Skoracki, Maciej, Correia, Maira A, Uchoa, Manoel A, Andrade, Manuella FG, Hermes, Marcel G, Miranda, Marcel S, Araújo, Marcel S de, Monné, Marcela L, Labruna, Marcelo B, Santis, Marcelo D de, Duarte, Marcelo, Knoff, Marcelo, Nogueira, Marcelo, Britto, Marcelo R de, Melo, Marcelo RS de, Carvalho, Marcelo R de, Tavares, Marcelo T, Kitahara, Marcelo V, Justo, Marcia CN, Botelho, Marcia JC, Couri, Márcia S, Borges-Martins, Márcio, Felix, Márcio, Oliveira, Marcio L de, Bologna, Marco A, Gottschalk, Marco S, Tavares, Marcos DS, Lhano, Marcos G, Bevilaqua, Marcus, Santos, Marcus TT, Domingues, Marcus V, Sallum, Maria AM, Digiani, María C, Santarém, Maria CA, Nascimento, Maria C do, Becerril, María de los AM, Santos, Maria EA dos, Passos, Maria I da S dos, Felippe-Bauer, Maria L, Cherman, Mariana A, Terossi, Mariana, Bartz, Marie LC, Barbosa, Marina F de C, Loeb, Marina V, Cohn-Haft, Mario, Cupello, Mario, Martins, Marlúcia B, Christofersen, Martin L, Bento, Matheus, Rocha, Matheus dos S, Martins, Maurício L, Segura, Melissa O, Cardenas, Melissa Q, Duarte, Mércia E, Ivie, Michael A, Mincarone, Michael M, Borges, Michela, Monné, Miguel A, Casagrande, Mirna M, Fernandez, Monica A, Piovesan, Mônica, Menezes, Naércio A, Benaim, Natalia P, Reategui, Natália S, Pedro, Natan C, Pecly, Nathalia H, Ferreira Júnior, Nelson, Silva Júnior, Nelson J da, Perioto, Nelson W, Hamada, Neusa, Degallier, Nicolas, Chao, Ning L, Ferla, Noeli J, Mielke, Olaf HH, Evangelista, Olivia, Shibatta, Oscar A, Oliveira, Otto MP, Albornoz, Pablo CL, Dellapé, Pablo M, Gonçalves, Pablo R, Shimabukuro, Paloma HF, Grossi, Paschoal, Rodrigues, Patrícia E da S, Lima, Patricia OV, Velazco, Paul, Santos, Paula B dos, Araújo, Paula B, Silva, Paula KR, Riccardi, Paula R, Garcia, Paulo C de A, Passos, Paulo GH, Corgosinho, Paulo HC, Lucinda, Paulo, Costa, Paulo MS, Alves, Paulo P, Roth, Paulo R de O, Coelho, Paulo RS, Duarte, Paulo RM, Carvalho, Pedro F de, Gnaspini, Pedro, Souza-Dias, Pedro GB, Linardi, Pedro M, Bartholomay, Pedro R, Demite, Peterson R, Bulirsch, Petr, Boll, Piter K, Pereira, Rachel MM, Silva, Rafael APF, Moura, Rafael B de, Boldrini, Rafael, Silva, Rafaela A da, Falaschi, Rafaela L, Cordeiro, Ralf TS, Mello, Ramon JCL, Singer, Randal A, Querino, Ranyse B, Heleodoro, Raphael A, Castilho, Raphael de C, Constantino, Reginaldo, Guedes, Reinaldo C, Carrenho, Renan, Gomes, Renata S, Gregorin, Renato, Machado, Renato JP, Bérnils, Renato S, Capellari, Renato S, Silva, Ricardo B, Kawada, Ricardo, Dias, Ricardo M, Siewert, Ricardo, Brugnera, Ricaro, Leschen, Richard AB, Constantin, Robert, Robbins, Robert, Pinto, Roberta R, Reis, Roberto E dos, Ramos, Robson T da C, Cavichioli, Rodney R, Barros, Rodolfo C de, Caires, Rodrigo A, Salvador, Rodrigo B, Marques, Rodrigo C, Araújo, Rodrigo C, Araujo, Rodrigo de O, Dios, Rodrigo de VP, Johnsson, Rodrigo, Feitosa, Rodrigo M, Hutchings, Roger W, Lara, Rogéria IR, Rossi, Rogério V, Gerstmeier, Roland, Ochoa, Ronald, Hutchings, Rosa SG, Ale-Rocha, Rosaly, Rocha, Rosana M da, Tidon, Rosana, Brito, Rosangela, Pellens, Roseli, Santos, Sabrina R dos, Santos, Sandra D dos, Paiva, Sandra V, Santos, Sandro, Oliveira, Sarah S de, Costa, Sávio C, Gardner, Scott L, Leal, Sebastián A Muñoz, Aloquio, Sergio, Bonecker, Sergio LC, Bueno, Sergio L de S, Almeida, Sérgio M de, Stampar, Sérgio N, Andena, Sérgio R, Posso, Sergio R, Lima, Sheila P, Gadelha, Sian de S, Thiengo, Silvana C, Cohen, Simone C, Brandão, Simone N, Rosa, Simone P, Ribeiro, Síria LB, Letana, Sócrates D, Santos, Sonia B dos, Andrade, Sonia CS, Dávila, Stephane, Vaz, Stéphanie, Peck, Stewart B, Christo, Susete W, Cunha, Suzan BZ, Gomes, Suzete R, Duarte, Tácio, Madeira-Ott, Taís, Marques, Taísa, Roell, Talita, Lima, Tarcilla C de, Sepulveda, Tatiana A, Maria, Tatiana F, Ruschel, Tatiana P, Rodrigues, Thaiana, Marinho, Thais A, Almeida, Thaís M de, Miranda, Thaís P, Freitas, Thales RO, Pereira, Thalles PL, Zacca, Thamara, Pacheco, Thaynara L, Martins, Thiago F, Alvarenga, Thiago M, Carvalho, Thiago R de, Polizei, Thiago TS, McElrath, Thomas C, Henry, Thomas, Pikart, Tiago G, Porto, Tiago J, Krolow, Tiago K, Carvalho, Tiago P, Lotufo, Tito M da C, Caramaschi, Ulisses, Pinheiro, Ulisses dos S, Pardiñas, Ulyses FJ, Maia, Valéria C, Tavares, Valeria, Costa, Valmir A, Amaral, Vanessa S do, Silva, Vera C, Wolff, Vera R dos S, Slobodian, Verônica, Silva, Vinícius B da, Espíndola, Vinicius C, Costa-Silva, Vinicius da, Bertaco, Vinicius de A, Padula, Vinícius, Ferreira, Vinicius S, Silva, Vitor CP da, Piacentini, Vítor de Q, Sandoval-Gómez, Vivian E, Trevine, Vivian, Sousa, Viviane R, Sant’Anna, Vivianne B de, Mathis, Wayne N, Souza, Wesley de O, Colombo, Wesley D, Tomaszewska, Wioletta, Wosiacki, Wolmar B, Ovando, Ximena MC, Leite, Yuri LR, Boeger, Walter A, Valim, Michel P, Zaher, Hussam, Rafael, José A, Forzza, Rafaela C, Percequillo, Alexandre R, Serejo, Cristiana S, Garraffoni, André RS, Santos, Adalberto J, Slipinski, Adam, Linzmeier, Adelita M, Calor, Adolfo R, Garda, Adrian A, Kury, Adriano B, Fernandes, Agatha CS, Agudo-Padrón, Aisur I, Akama, Alberto, Silva Neto, Alberto M da, Burbano, Alejandro L, Menezes, Aleksandra, Pereira-Colavite, Alessandre, Anichtchenko, Alexander, Lees, Alexander C, Bezerra, Alexandra MR, Domahovski, Alexandre C, Pimenta, Alexandre D, Aleixo, Alexandre LP, Marceniuk, Alexandre P, Paula, Alexandre S de, Somavilla, Alexandre, Specht, Alexandre, Camargo, Alexssandro, Newton, Alfred F, Silva, Aline AS da, Santos, Aline B dos, Tassi, Aline D, Aragão, Allan C, Santos, Allan PM, Migotto, Alvaro E, Mendes, Amanda C, Cunha, Amanda, Chagas Júnior, Amazonas, Sousa, Ana AT de, Pavan, Ana C, Almeida, Ana CS, Peronti, Ana LBG, Henriques-Oliveira, Ana L, Prudente, Ana L, Tourinho, Ana L, Pes, Ana MO, Carmignotto, Ana P, Wengrat, Ana PG da Silva, Dornellas, Ana PS, Molin, Anamaria Dal, Puker, Anderson, Morandini, André C, Ferreira, André da S, Martins, André L, Esteves, André M, Fernandes, André S, Roza, André S, Köhler, Andreas, Paladini, Andressa, Andrade, Andrey J de, Pinto, Ângelo P, Salles, Anna C de A, Gondim, Anne I, Amaral, Antonia CZ, Rondón, Antonio AA, Brescovit, Antonio, Lofego, Antônio C, Marques, Antonio C, Macedo, Antonio, Andriolo, Artur, Henriques, Augusto L, Ferreira Júnior, Augusto L, Lima, Aurino F de, Barros, Ávyla R de A, Brito, Ayrton do R, Romera, Bárbara LV, Vasconcelos, Beatriz MC de, Frable, Benjamin W, Santos, Bernardo F, Ferraz, Bernardo R, Rosa, Brunno B, Sampaio, Brunno HL, Bellini, Bruno C, Clarkson, Bruno, Oliveira, Bruno G de, Corrêa, Caio CD, Martins, Caleb C, Castro-Guedes, Camila F de, Souto, Camilla, Bicho, Carla de L, Cunha, Carlo M, Barboza, Carlos A de M, Lucena, Carlos AS de, Barreto, Carlos, Santana, Carlos DCM de, Agne, Carlos EQ, Mielke, Carlos GC, Caetano, Carlos HS, Flechtmann, Carlos HW, Lamas, Carlos JE, Rocha, Carlos, Mascarenhas, Carolina S, Margaría, Cecilia B, Waichert, Cecilia, Digiani, Celina, Haddad, Célio FB, Azevedo, Celso O, Benetti, Cesar J, Santos, Charles MD dos, Bartlett, Charles R, Bonvicino, Cibele, Ribeiro-Costa, Cibele S, Santos, Cinthya SG, Justino, Cíntia EL, Canedo, Clarissa, Bonecker, Claudia C, Santos, Cláudia P, Carvalho, Claudio JB de, Gonçalves, Clayton C, Galvão, Cleber, Costa, Cleide, Oliveira, Cléo DC de, Schwertner, Cristiano F, Andrade, Cristiano L, Pereira, Cristiano M, Sampaio, Cristiano, Dias, Cristina de O, Lucena, Daercio A de A, Manfio, Daiara, Amorim, Dalton de S, Queiroz, Dalva L de, Colpani, Daniara, Abbate, Daniel, Aquino, Daniel A, Burckhardt, Daniel, Cavallari, Daniel C, Prado, Daniel de C Schelesky, Praciano, Daniel L, Basílio, Daniel S, Bená, Daniela de C, Toledo, Daniela GP de, Takiya, Daniela M, Fernandes, Daniell RR, Ament, Danilo C, Cordeiro, Danilo P, Silva, Darliane E, Pollock, Darren A, Muniz, David B, Gibson, David I, Nogueira, David S, Marques, Dayse WA, Lucatelli, Débora, Garcia, Deivys MA, Baêta, Délio, Ferreira, Denise NM, Rueda-Ramírez, Diana, Fachin, Diego A, Souza, Diego de S, Rodrigues, Diego F, Pádua, Diego G de, Barbosa, Diego N, Dolibaina, Diego R, Amaral, Diogo C, Chandler, Donald S, Maccagnan, Douglas HB, Caron, Edilson, Carvalho, Edrielly, Adriano, Edson A, Abreu Júnior, Edson F de, Pereira, Edson HL, Viegas, Eduarda FG, Carneiro, Eduardo, Colley, Eduardo, Eizirik, Eduardo, Santos, Eduardo F dos, Shimbori, Eduardo M, Suárez-Morales, Eduardo, Arruda, Eliane P de, Chiquito, Elisandra A, Lima, Élison FB, Castro, Elizeu B de, Orlandin, Elton, Nascimento, Elynton A do, Razzolini, Emanuel, Gama, Emanuel RR, Araujo, Enilma M de, Nishiyama, Eric Y, Spiessberger, Erich L, Santos, Érika CL dos, Contreras, Eugenia F, Galati, Eunice AB, Oliveira Junior, Evaldo C de, Gallardo, Fabiana, Hernandes, Fabio A, Lansac-Tôha, Fábio A, Pitombo, Fabio B, Dario, Fabio Di, Santos, Fábio L dos, Mauro, Fabio, Nascimento, Fabio O do, Olmos, Fabio, Amaral, Fabio R, Schunck, Fabio, Godoi, Fábio SP de, Machado, Fabrizio M, Barbo, Fausto E, Agrain, Federico A, Ribeiro, Felipe B, Moreira, Felipe FF, Barbosa, Felipe F, Silva, Fenanda S, Cavalcanti, Fernanda F, Straube, Fernando C, Carbayo, Fernando, Carvalho Filho, Fernando, Zanella, Fernando CV, Jacinavicius, Fernando de C, Farache, Fernando HA, Leivas, Fernando, Dias, Fernando MS, Mantellato, Fernando, Vaz-de-Mello, Fernando Z, Gudin, Filipe M, Albuquerque, Flávio, Molina, Flavio B, Passos, Flávio D, Shockley, Floyd W, Pinheiro, Francielly F, Mello, Francisco de AG de, Nascimento, Francisco E de L, Franco, Francisco L, Oliveira, Francisco L de, Melo, Francisco T de V, Quijano, Freddy RB, Salles, Frederico F, Biffi, Gabriel, Queiroz, Gabriel C, Bizarro, Gabriel L, Hrycyna, Gabriela, Leviski, Gabriela, Powell, Gareth S, Santos, Geane B dos, Morse, Geoffrey E, Brown, George, Mattox, George MT, Zimbrão, Geraldo, Carvalho, Gervásio S, Miranda, Gil FG, Moraes, Gilberto J de, Lourido, Gilcélia M, Neves, Gilmar P, Moreira, Gilson RP, Montingelli, Giovanna G, Maurício, Giovanni N, Marconato, Gláucia, Lopez, Guilherme EL, Silva, Guilherme L da, Muricy, Guilherme, Brito, Guilherme RR, Garbino, Guilherme ST, Flores, Gustavo E, Graciolli, Gustavo, Libardi, Gustavo S, Proctor, Heather C, Gil-Santana, Helcio R, Varella, Henrique R, Escalona, Hermes E, Schmitz, Hermes J, Rodrigues, Higor DD, Galvão Filho, Hilton de C, Quintino, Hingrid YS, Pinto, Hudson A, Rainho, Hugo L, Miyahira, Igor C, Gonçalves, Igor de S, Martins, Inês X, Cardoso, Irene A, Oliveira, Ismael B de, Franz, Ismael, Fernandes, Itanna O, Golfetti, Ivan F, S. Campos-Filho, Ivanklin, Oliveira, Ivo de S, Delabie, Jacques HC, Oliveira, Jader de, Prando, Jadila S, Patton, James L, Bitencourt, Jamille de A, Silva, Janaina M, Santos, Jandir C, Arruda, Janine O, Valderrama, Jefferson S, Dalapicolla, Jeronymo, Oliveira, Jéssica P, Hájek, Jiri, Morselli, João P, Narita, João P, Martin, João PI, Grazia, Jocélia, McHugh, Joe, Cherem, Jorge J, Farias Júnior, José AS, Fernandes, Jose AM, Pacheco, José F, Birindelli, José LO, Rezende, José M, Avendaño, Jose M, Duarte, José M Barbanti, Ribeiro, José R Inácio, Mermudes, José RM, Pujol-Luz, José R, Santos, Josenilson R dos, Câmara, Josenir T, Teixeira, Joyce A, Prado, Joyce R do, Botero, Juan P, Almeida, Julia C, Kohler, Julia, Gonçalves, Julia P, Beneti, Julia S, Donahue, Julian P, Alvim, Juliana, Almeida, Juliana C, Segadilha, Juliana L, Wingert, Juliana M, Barbosa, Julianna F, Ferrer, Juliano, Santos, Juliano F dos, Kuabara, Kamila MD, Nascimento, Karine B, Schoeninger, Karine, Campião, Karla M, Soares, Karla, Zilch, Kássia, Barão, Kim R, Teixeira, Larissa, Sousa, Laura D do NM de, Dumas, Leandro L, Vieira, Leandro M, Azevedo, Leonardo HG, Carvalho, Leonardo S, Souza, Leonardo S de, Rocha, Leonardo SG, Bernardi, Leopoldo FO, Vieira, Letícia M, Johann, Liana, Salvatierra, Lidianne, Oliveira, Livia de M, Loureiro, Lourdes MA El-moor, Barreto, Luana B, Barros, Luana M, Lecci, Lucas, Camargos, Lucas M de, Lima, Lucas RC, Almeida, Lucia M, Martins, Luciana R, Marinoni, Luciane, Moura, Luciano de A, Lima, Luciano, Naka, Luciano N, Miranda, Lucília S, Salik, Lucy M, Bezerra, Luis EA, Silveira, Luis F, Campos, Luiz A, Castro, Luiz AS de, Pinho, Luiz C, Silveira, Luiz FL, Iniesta, Luiz FM, Tencatt, Luiz FC, Simone, Luiz RL, Malabarba, Luiz R, Cruz, Luiza S da, Sekerka, Lukas, Barros, Lurdiana D, Santos, Luziany Q, Skoracki, Maciej, Correia, Maira A, Uchoa, Manoel A, Andrade, Manuella FG, Hermes, Marcel G, Miranda, Marcel S, Araújo, Marcel S de, Monné, Marcela L, Labruna, Marcelo B, Santis, Marcelo D de, Duarte, Marcelo, Knoff, Marcelo, Nogueira, Marcelo, Britto, Marcelo R de, Melo, Marcelo RS de, Carvalho, Marcelo R de, Tavares, Marcelo T, Kitahara, Marcelo V, Justo, Marcia CN, Botelho, Marcia JC, Couri, Márcia S, Borges-Martins, Márcio, Felix, Márcio, Oliveira, Marcio L de, Bologna, Marco A, Gottschalk, Marco S, Tavares, Marcos DS, Lhano, Marcos G, Bevilaqua, Marcus, Santos, Marcus TT, Domingues, Marcus V, Sallum, Maria AM, Digiani, María C, Santarém, Maria CA, Nascimento, Maria C do, Becerril, María de los AM, Santos, Maria EA dos, Passos, Maria I da S dos, Felippe-Bauer, Maria L, Cherman, Mariana A, Terossi, Mariana, Bartz, Marie LC, Barbosa, Marina F de C, Loeb, Marina V, Cohn-Haft, Mario, Cupello, Mario, Martins, Marlúcia B, Christofersen, Martin L, Bento, Matheus, Rocha, Matheus dos S, Martins, Maurício L, Segura, Melissa O, Cardenas, Melissa Q, Duarte, Mércia E, Ivie, Michael A, Mincarone, Michael M, Borges, Michela, Monné, Miguel A, Casagrande, Mirna M, Fernandez, Monica A, Piovesan, Mônica, Menezes, Naércio A, Benaim, Natalia P, Reategui, Natália S, Pedro, Natan C, Pecly, Nathalia H, Ferreira Júnior, Nelson, Silva Júnior, Nelson J da, Perioto, Nelson W, Hamada, Neusa, Degallier, Nicolas, Chao, Ning L, Ferla, Noeli J, Mielke, Olaf HH, Evangelista, Olivia, Shibatta, Oscar A, Oliveira, Otto MP, Albornoz, Pablo CL, Dellapé, Pablo M, Gonçalves, Pablo R, Shimabukuro, Paloma HF, Grossi, Paschoal, Rodrigues, Patrícia E da S, Lima, Patricia OV, Velazco, Paul, Santos, Paula B dos, Araújo, Paula B, Silva, Paula KR, Riccardi, Paula R, Garcia, Paulo C de A, Passos, Paulo GH, Corgosinho, Paulo HC, Lucinda, Paulo, Costa, Paulo MS, Alves, Paulo P, Roth, Paulo R de O, Coelho, Paulo RS, Duarte, Paulo RM, Carvalho, Pedro F de, Gnaspini, Pedro, Souza-Dias, Pedro GB, Linardi, Pedro M, Bartholomay, Pedro R, Demite, Peterson R, Bulirsch, Petr, Boll, Piter K, Pereira, Rachel MM, Silva, Rafael APF, Moura, Rafael B de, Boldrini, Rafael, Silva, Rafaela A da, Falaschi, Rafaela L, Cordeiro, Ralf TS, Mello, Ramon JCL, Singer, Randal A, Querino, Ranyse B, Heleodoro, Raphael A, Castilho, Raphael de C, Constantino, Reginaldo, Guedes, Reinaldo C, Carrenho, Renan, Gomes, Renata S, Gregorin, Renato, Machado, Renato JP, Bérnils, Renato S, Capellari, Renato S, Silva, Ricardo B, Kawada, Ricardo, Dias, Ricardo M, Siewert, Ricardo, Brugnera, Ricaro, Leschen, Richard AB, Constantin, Robert, Robbins, Robert, Pinto, Roberta R, Reis, Roberto E dos, Ramos, Robson T da C, Cavichioli, Rodney R, Barros, Rodolfo C de, Caires, Rodrigo A, Salvador, Rodrigo B, Marques, Rodrigo C, Araújo, Rodrigo C, Araujo, Rodrigo de O, Dios, Rodrigo de VP, Johnsson, Rodrigo, Feitosa, Rodrigo M, Hutchings, Roger W, Lara, Rogéria IR, Rossi, Rogério V, Gerstmeier, Roland, Ochoa, Ronald, Hutchings, Rosa SG, Ale-Rocha, Rosaly, Rocha, Rosana M da, Tidon, Rosana, Brito, Rosangela, Pellens, Roseli, Santos, Sabrina R dos, Santos, Sandra D dos, Paiva, Sandra V, Santos, Sandro, Oliveira, Sarah S de, Costa, Sávio C, Gardner, Scott L, Leal, Sebastián A Muñoz, Aloquio, Sergio, Bonecker, Sergio LC, Bueno, Sergio L de S, Almeida, Sérgio M de, Stampar, Sérgio N, Andena, Sérgio R, Posso, Sergio R, Lima, Sheila P, Gadelha, Sian de S, Thiengo, Silvana C, Cohen, Simone C, Brandão, Simone N, Rosa, Simone P, Ribeiro, Síria LB, Letana, Sócrates D, Santos, Sonia B dos, Andrade, Sonia CS, Dávila, Stephane, Vaz, Stéphanie, Peck, Stewart B, Christo, Susete W, Cunha, Suzan BZ, Gomes, Suzete R, Duarte, Tácio, Madeira-Ott, Taís, Marques, Taísa, Roell, Talita, Lima, Tarcilla C de, Sepulveda, Tatiana A, Maria, Tatiana F, Ruschel, Tatiana P, Rodrigues, Thaiana, Marinho, Thais A, Almeida, Thaís M de, Miranda, Thaís P, Freitas, Thales RO, Pereira, Thalles PL, Zacca, Thamara, Pacheco, Thaynara L, Martins, Thiago F, Alvarenga, Thiago M, Carvalho, Thiago R de, Polizei, Thiago TS, McElrath, Thomas C, Henry, Thomas, Pikart, Tiago G, Porto, Tiago J, Krolow, Tiago K, Carvalho, Tiago P, Lotufo, Tito M da C, Caramaschi, Ulisses, Pinheiro, Ulisses dos S, Pardiñas, Ulyses FJ, Maia, Valéria C, Tavares, Valeria, Costa, Valmir A, Amaral, Vanessa S do, Silva, Vera C, Wolff, Vera R dos S, Slobodian, Verônica, Silva, Vinícius B da, Espíndola, Vinicius C, Costa-Silva, Vinicius da, Bertaco, Vinicius de A, Padula, Vinícius, Ferreira, Vinicius S, Silva, Vitor CP da, Piacentini, Vítor de Q, Sandoval-Gómez, Vivian E, Trevine, Vivian, Sousa, Viviane R, Sant’Anna, Vivianne B de, Mathis, Wayne N, Souza, Wesley de O, Colombo, Wesley D, Tomaszewska, Wioletta, Wosiacki, Wolmar B, Ovando, Ximena MC, and Leite, Yuri LR

Abstract

The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others.

Published
2024

33. A new metric for conducting 5‐year reviews to evaluate recovery progress under the Endangered Species Act.

Author

Davis, Olivia N., Molano‐Flores, Brenda, Li, Ya‐Wei, Allen, Maximilian L., Davis, Mark A., Parkos, Joseph J., McIntyre, Susan, Di Giovanni, Alexander J., McElrath, Thomas C., Carter, Andrew, Evansen, Megan, Sheehan, Connor, and Gerber, Leah R.

Subjects
ENDANGERED species, WILDLIFE conservation, BIOLOGISTS, SPECIES, HABITATS, POPULATION viability analysis
Abstract

The Endangered Species Act (ESA) provides legal protection to imperiled populations and their associated habitats. As a part of this process, listed species must undergo a general status review (also called 5‐Year Review) to assess the progress toward recovery every 5 years. However, almost all 5‐year reviews result in a status of "no change," prompting scientists to question if the review process is robust enough to detect changes in recovery. The U.S. Fish and Wildlife Service (USFWS) was therefore interested in developing a standardized metric for monitoring more nuanced recovery progress as part of the status review. In collaboration with the USFWS, over 75 biologists from five different organizations developed and tested a set of novel metrics to summarize recovery progress of listed species by considering current and future conditions, threats, and conservation measures. We found that, although the majority of species had reviews with a recommendation of no change, scorers were able to use the metrics to interpret more nuanced changes in the 3Rs (resiliency, redundancy, and representation), threats, and conservation measures than in the status review. Our results suggest that these metrics could illuminate more nuanced areas of recovery and decline in species' conditions, but consistency among scorers and status reports should be a focus of future development. Our approach offers a rigorous set of metrics to systematically track the recovery progress of all ESA species. [ABSTRACT FROM AUTHOR]

Published
2024
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38. 485 Association between perinatal phthalate metabolite concentrations and postpartum glucose levels: a prospective observational study

Author

Ponzano, Marta, primary, Preston, Emma V., additional, Quinn, Marlee R., additional, Cantonwine, David E., additional, Williams, Paige L., additional, Seely, Ellen W., additional, Wylie, Blair, additional, Hacker, Michele R., additional, Brown, Florence M., additional, O'Brien, Karen, additional, Hauser, Russ, additional, Bellavia, Andrea, additional, Powe, Camille E., additional, McElrath, Thomas, additional, and James-Todd, Tamarra, additional

Published
2024
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42. First-Trimester Urine Concentrations of Phthalate Metabolites and Phenols and Placenta miRNA Expression in a Cohort of U.S. Women

Author

LaRocca, Jessica, Binder, Alexandra M, McElrath, Thomas F, and Michels, Karin B

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Conditions Affecting the Embryonic and Fetal Periods, Genetics, Perinatal Period - Conditions Originating in Perinatal Period, Pediatric, Biotechnology, Clinical Research, Estrogen, Prevention, Aetiology, 2.1 Biological and endogenous factors, Reproductive health and childbirth, Adult, Cohort Studies, Endocrine Disruptors, Female, Gene Expression Regulation, Humans, MicroRNAs, Phenols, Phthalic Acids, Placenta, Pregnancy, Pregnancy Trimester, First, Environmental Sciences, Medical and Health Sciences, Toxicology, Biomedical and clinical sciences, Environmental sciences, Health sciences
Abstract

BackgroundThere is increasing concern that early-life exposure to endocrine-disrupting chemicals (EDCs) can influence the risk of disease development. Phthalates and phenols are two classes of suspected EDCs that are used in a variety of everyday consumer products, including plastics, epoxy resins, and cosmetics. In utero exposure to EDCs may affect disease propensity through epigenetic mechanisms.ObjectiveThe objective of this study was to determine whether prenatal exposure to multiple EDCs is associated with changes in miRNA expression of human placenta, and whether miRNA alterations are associated with birth outcomes.MethodsOur study was restricted to a total of 179 women co-enrolled in the Harvard Epigenetic Birth Cohort and the Predictors of Preeclampsia Study. We analyzed associations between first-trimester urine concentrations of 8 phenols and 11 phthalate metabolites and expression of 29 candidate miRNAs in placenta by qRT-PCR.ResultsFor three miRNAs--miR-142-3p, miR15a-5p, and miR-185--we detected associations between Σphthalates or Σphenols on expression levels (p < 0.05). By assessing gene ontology enrichment, we determined the potential mRNA targets of these microRNAs predicted in silico were associated with several biological pathways, including the regulation of protein serine/threonine kinase activity. Four gene ontology biological processes were enriched among genes significantly correlated with the expression of miRNAs associated with EDC burden.ConclusionsOverall, these results suggest that prenatal phenol and phthalate exposure is associated with altered miRNA expression in placenta, suggesting a potential mechanism of EDC toxicity in humans.

Published
2016

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