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518 results on '"McElhaney, Janet E."'

5. Immunogenicity and safety of a tri-antigenic versus a mono-antigenic hepatitis B vaccine in adults (PROTECT): a randomised, double-blind, phase 3 trial

Author

Vesikari, Timo, Langley, Joanne M, Gantt, Soren, Dionne, Marc, McElhaney, Janet, Rankin, Bruce, Griffin, Carl, Turner, Mark, Kirstein, Judith, Rizzardi, Barbara E, Williams, Hayes, Ahonen, Anitta, Henriksson, Olli, Ukkonen, Benita, Paassilta, Marita, Segall, Nathan, Ward, Brian J, Cooper, Curtis, Poliquin, Guillaume, Smith, Bruce, Van Damme, Pierre, Leroux-Roels, Isabel, Leroux-Roels, Geert, Machluf, Nathalie, Spaans, Johanna N, Yassin-Rajkumar, Bebi, Anderson, David E, Popovic, Vlad, Diaz-Mitoma, Francisco, McElhaney, Janet E, and van Damme, Pierre

Published
2021
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8. Effectiveness of Influenza Vaccination on Hospitalizations and Risk Factors for Severe Outcomes in Hospitalized Patients With COPD

Author

Lagace-Wiens, Philippe, Light, Bruce, Poirier, Andre, Smith, Stephanie, Taylor, Gregory, Mulpuru, Sunita, Li, Li, Ye, Lingyun, Hatchette, Todd, Andrew, Melissa K., Ambrose, Ardith, Boivin, Guy, Bowie, William, Chit, Ayman, Dos Santos, Gael, ElSherif, May, Green, Karen, Haguinet, Francois, Halperin, Scott A., Ibarguchi, Barbara, Johnstone, Jennie, Katz, Kevin, Langley, Joanne M., LeBlanc, Jason, Loeb, Mark, MacKinnon-Cameron, Donna, McCarthy, Anne, McElhaney, Janet E., McGeer, Allison, Powis, Jeff, Richardson, David, Semret, Makeda, Shinde, Vivek, Smyth, Daniel, Trottier, Sylvie, Valiquette, Louis, Webster, Duncan, and McNeil, Shelly A.

Published
2019
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9. Immune Responses to a Recombinant Glycoprotein E Herpes Zoster Vaccine in Adults Aged 50 Years or Older

Author

ZOE-50/70 Study Group, Cunningham, Anthony L., Heineman, Thomas C., Lal, Himal, Godeaux, Olivier, Chlibek, Roman, Hwang, Shinn-Jang, McElhaney, Janet E., Vesikari, Timo, Andrews, Charles, Choi, Won Suk, Esen, Meral, Ikematsu, Hideyuki, Choma, Martina Kovac, Pauksens, Karlis, Ravault, Stéphanie, Salaun, Bruno, Schwarz, Tino F., Smetana, Jan, Vanden Abeele, Carline, Van den Steen, Peter, Vastiau, Ilse, Weckx, Lily Yin, and Levin, Myron J.

Published
2018

11. Influenza vaccine effectiveness to prevent influenza-related hospitalizations and serious outcomes in Canadian adults over the 2011/12 through 2013/14 influenza seasons: A pooled analysis from the Canadian Immunization Research Network (CIRN) Serious Outcomes Surveillance (SOS Network)

Author

Nichols, Michaela K., Andrew, Melissa K., Hatchette, Todd F., Ambrose, Ardith, Boivin, Guy, Bowie, William, Chit, Ayman, Dos Santos, Gael, ElSherif, May, Green, Karen, Haguinet, Francois, Halperin, Scott A., Ibarguchi, Barbara, Johnstone, Jennie, Katz, Kevin, Lagacé-Wiens, Phillipe, Langley, Joanne M., LeBlanc, Jason, Loeb, Mark, MacKinnon-Cameron, Donna, McCarthy, Anne, McElhaney, Janet E., McGeer, Allison, Poirier, Andre, Powis, Jeff, Richardson, David, Schuind, Anne, Semret, Makeda, Shinde, Vivek, Smith, Stephanie, Smyth, Daniel, Stiver, Grant, Taylor, Geoffrey, Trottier, Sylvie, Valiquette, Louis, Webster, Duncan, Ye, Lingyun, and McNeil, Shelly A.

Published
2018
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12. The role of inflammation in age-related disease

Author

Howcroft, T Kevin, Campisi, Judith, Louis, Germaine Buck, Smith, Martyn T, Wise, Bradley, Wyss-Coray, Tony, Augustine, Alison Deckhut, McElhaney, Janet E, Kohanski, Ron, and Sierra, Felipe

Subjects
Biomedical and Clinical Sciences, Immunology, Aging, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Good Health and Well Being, Animals, Cellular Senescence, Chronic Disease, Humans, Inflammation, Neoplasms, Neurodegenerative Diseases, Biochemistry and cell biology, Clinical sciences
Abstract

The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation inAge-Related Disease, was held September 6th-7th, 2012 in Bethesda, MD. It is now recognized that a mild pro-inflammatory state is correlated with the major degenerative diseases of the elderly. The focus of the workshop was to better understand the origins and consequences of this low level chronic inflammation in order to design appropriate interventional studies aimed at improving healthspan. Four sessions explored the intrinsic, environmental exposures and immune pathways by which chronic inflammation are generated, sustained, and lead to age-associated diseases. At the conclusion of the workshop recommendations to accelerate progress toward understanding the mechanistic bases of chronic disease were identified.

Published
2013

16. The Importance of Frailty in the Assessment of Influenza Vaccine Effectiveness Against Influenza-Related Hospitalization in Elderly People

Author

Serious Outcomes Surveillance Network of the Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network (PCIRN) and the Toronto Invasive Bacterial Diseases Network (TIBDN), Andrew, Melissa K., Shinde, Vivek, Ye, Lingyun, Hatchette, Todd, Haguinet, François, Santos, Gael Dos, McElhaney, Janet E., Ambrose, Ardith, Boivin, Guy, Bowie, William, Chit, Ayman, ElSherif, May, Green, Karen, Halperin, Scott, Ibarguchi, Barbara, Johnstone, Jennie, Katz, Kevin, Langley, Joanne, Leblanc, Jason, Loeb, Mark, MacKinnon-Cameron, Donna, McCarthy, Anne, McGeer, Allison, Powis, Jeff, Richardson, David, Semret, Makeda, Stiver, Grant, Trottier, Sylvie, Valiquette, Louis, Webster, Duncan, and McNeil, Shelly A.

Published
2017

17. Protection from Omicron Infection in Residents of Nursing and Retirement Homes in Ontario, Canada

Author

Breznik, Jessica A., primary, Rahim, Ahmad, additional, Kajaks, Tara, additional, Hagerman, Megan, additional, Bilaver, Lucas, additional, Colwill, Karen, additional, Dayam, Roaya M., additional, Gingras, Anne-Claude, additional, Verschoor, Chris P., additional, McElhaney, Janet E., additional, Bramson, Jonathan L., additional, Bowdish, Dawn M.E., additional, and Costa, Andrew P., additional

Published
2023
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24. Implementation of the Community Assets Supporting Transitions (CAST) transitional care intervention for older adults with multimorbidity and depressive symptoms: A qualitative descriptive study

Author

McAiney, Carrie, primary, Markle-Reid, Maureen, additional, Ganann, Rebecca, additional, Whitmore, Carly, additional, Valaitis, Ruta, additional, Urajnik, Diana J., additional, Fisher, Kathryn, additional, Ploeg, Jenny, additional, Petrie, Penelope, additional, McMillan, Fran, additional, and McElhaney, Janet E., additional

Published
2022
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27. Respiratory Syncytial Virus and Other Respiratory Viral Infections in Older Adults With Moderate to Severe Influenza-like Illness

Author

Falsey, Ann R., McElhaney, Janet E., Beran, Jiri, van Essen, Gerrit A., Duval, Xavier, Esen, Meral, Galtier, Florence, Gervais, Pierre, Hwang, Shinn-Jang, Kremsner, Peter, Launay, Odile, Leroux-Roels, Geert, McNeil, Shelly A., Nowakowski, Andrzej, Richardus, Jan Hendrik, Ruiz-Palacios, Guillermo, St Rose, Suzanne, Devaster, Jeanne-Marie, Oostvogels, Lidia, Durviaux, Serge, and Taylor, Sylvia

Published
2014

29. Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness.

Author

ElSherif, May, Andrew, Melissa K, Ye, Lingyun, Ambrose, Ardith, Boivin, Guy, Bowie, William, David, Marie-Pierre, Gruselle, Olivier, Halperin, Scott A, Hatchette, Todd F, Johnstone, Jennie, Katz, Kevin, Langley, Joanne M, Loeb, Mark, MacKinnon-Cameron, Donna, McCarthy, Anne, McElhaney, Janet E, McGeer, Allison, Poirier, Andre, and Pirçon, Jean-Yves

Subjects
RESPIRATORY syncytial virus infections, ACUTE flaccid paralysis, ACUTE diseases, INFLUENZA viruses, HUMAN metapneumovirus infection, OLDER people, LENGTH of stay in hospitals
Abstract

Background Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the disease burden in Canadian adults aged ≥50 years hospitalized with RSV. Methods Using administrative data and nasopharyngeal swabs collected from active surveillance among adults aged ≥50 years hospitalized with an acute respiratory illness (ARI) during the 2012–2013, 2013–2014, and 2014–2015 influenza seasons, RSV was identified using a respiratory virus multiplex polymerase chain reaction test to describe the associated disease burden, incidence, and healthcare costs. Results Of 7797 patients tested, 371 (4.8%) were RSV positive (2.2% RSV-A and 2.6% RSV-B). RSV prevalence varied by season from 4.2% to 6.2%. Respiratory virus coinfection was observed in 11.6% (43/371) of RSV cases, with influenza A being the most common. RSV hospitalization rates varied between seasons and increased with age, from 8–12 per 100 000 population in adults aged 50–59 years to 174–487 per 100 000 in adults aged ≥80 years. The median age of RSV cases was 74.9 years, 63.7% were female, and 98.1% of cases had ≥1 comorbidity. Among RSV cases, the mean length of hospital stay was 10.6 days, 13.7% were admitted to the intensive care unit, 6.4% required mechanical ventilation, and 6.1% died. The mean cost per RSV case was $13 602 (Canadian dollars) but varied by age and Canadian province. Conclusions This study adds to the growing literature on adult RSV burden by showing considerable morbidity, mortality, and healthcare costs in hospitalized adults aged ≥50 years with ARIs such as influenza. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Protection from Omicron infection in residents of nursing and retirement homes in Ontario, Canada

Author

Breznik, Jessica A., primary, Rahim, Ahmad, additional, Kajaks, Tara, additional, Hagerman, Megan, additional, Bilaver, Lucas, additional, Colwill, Karen, additional, Dayam, Roaya, additional, Gingras, Anne-Claude, additional, Verschoor, Chris P., additional, McElhaney, Janet E., additional, Bramson, Jonathan L., additional, Bowdish, Dawn M.E., additional, and Costa, Andrew P, additional

Published
2022
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31. Older Age and Frailty are Associated with Higher Mortality but Lower ICU Admission with COVID-19

Author

Andrew, Melissa K., primary, Godin, Judith, additional, LeBlanc, Jason, additional, Boivin, Guy, additional, Valiquette, Louis, additional, McGeer, Allison, additional, McElhaney, Janet E., additional, Hatchette, Todd F., additional, ElSherif, May, additional, MacKinnon-Cameron, Donna, additional, Wilson, Kevin, additional, Ambrose, Ardith, additional, Trottier, Sylvie, additional, Loeb, Mark, additional, Smith, Stephanie W., additional, Katz, Kevin, additional, McCarthy, Anne, additional, and McNeil, Shelly A., additional

Published
2022
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32. AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial

Author

McElhaney, Janet E, Beran, Jiri, Devaster, Jeanne-Marie, Esen, Meral, Launay, Odile, Leroux-Roels, Geert, Ruiz-Palacios, Guillermo M, van Essen, Gerrit A, Caplanusi, Adrian, Claeys, Carine, Durand, Christelle, Duval, Xavier, El Idrissi, Mohamed, Falsey, Ann R, Feldman, Gregory, Frey, Sharon E, Galtier, Florence, Hwang, Shinn-Jang, Innis, Bruce L, Kovac, Martina, Kremsner, Peter, McNeil, Shelly, Nowakowski, Andrzej, Richardus, Jan Hendrik, Trofa, Andrew, and Oostvogels, Lidia

Published
2013
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37. Additional file 1 of Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells

Author

Picard, Emilie, Armstrong, Sarah, Andrew, Melissa K., Haynes, Laura, Loeb, Mark, Pawelec, Graham, Kuchel, George A., McElhaney, Janet E., and Verschoor, Chris P.

Abstract

Additional file 1: Table S1. Summary of antibody and cell-mediated immune responses pre- and 4-weeks post-influenza vaccination. Table S2. Results from multivariable analysis of vaccine antibody responses in older adults where plasma TNF, IL-6 and CRP were simultaneously included as fixed effects. Table S3. Summary of participants enrolled in the follow-up cohort, including pre-vaccination levels of inflammatory mediators and antibody responses pre- and 4-weeks post-influenza vaccination. Figure S1. Associations between inflammatory mediator levels and antibody responses of high-dose vaccine recipients are independent of frailty. Figure S2. Joint effects of TNF and IL-6 in the association with post-vaccination antibody titres in standard- dose (SD) and high-dose (HD) older recipients. Figure S3. Sex-stratified models of systemic inflammation and the response to influenza vaccination in young (YA) and older (OA) adults vaccinated with either standard (SD) or high (HD) dose vaccine. Figure S4. ILT2+CD57+ Dim NK-cells mediate a significant proportion of the effect of frailty on post-vaccination A/H3N2 antibody titres in older high-dose recipients.

Published
2022
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38. Additional file 1 of Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons

Author

Verschoor, Chris P., Belsky, Daniel W., Andrew, Melissa K., Haynes, Laura, Loeb, Mark, Pawelec, Graham, McElhaney, Janet E., and Kuchel, George A.

Abstract

Additional file 1: Supplementary Table 1. Regression table describing the association between standardized, natural-log 4-week antibody titres and ΔBA in high-dose recipients, including a two-way interaction between ΔBA and CMV serostatus. Supplementary Table 2. KDM training parameters derived from the CLSA and used calculate biological aging in the vaccination cohort. Supplementary Figure 1. Characteristics of KDM biological age (BA) in the CLSA training cohort and associations with the frailty index (FI). A) Pearson’s correlation (R) for BA with chronological age and significance (p) for females (red asterisk) and males (blue dots). B) Distribution of ΔBA in females and males, including the mean and standard deviation. C) Differences in years for ΔBA (and 95% confidence interval) for pre-frail (0.10=FI

Published
2022
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40. Comparison of the Safety and Immunogenicity of 2 Respiratory Syncytial Virus (RSV) Vaccines—Nonadjuvanted Vaccine or Vaccine Adjuvanted with Alum—Given Concomitantly with Influenza Vaccine to High-Risk Elderly Individuals

Author

Falsey, Ann R., Walsh, Edward E., Capellan, Jose, Gravenstein, Stefan, Zambon, Maria, Yau, Eddy, Gorse, Geoffrey J., Edelman, Robert, Hayden, Frederick G., McElhaney, Janet E., Neuzil, Kathleen M., Nichol, Kristen L., Simões, Eric A. F., Wright, Peter F., and Sales, Valérie M.-P.

Published
2008
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47. Considering Frailty in SARS-CoV-2 Vaccine Development: How Geriatricians Can Assist

Author

Andrew,Melissa K, Schmader,Kenneth E, Rockwood,Kenneth, Clarke,Barry, and McElhaney,Janet E

Subjects
Clinical Interventions in Aging
Abstract

Melissa K Andrew,1,2 Kenneth E Schmader,3 Kenneth Rockwood,1 Barry Clarke,4 Janet E McElhaney5 1Department of Medicine, Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada; 2Canadian Center for Vaccinology, Halifax, Nova Scotia, Canada; 3Division of Geriatrics, Duke University Medical Center and GRECC, Durham Veterans Affairs Medical Center, Durham, North Carolina, USA; 4Department of Family Medicine, Dalhousie University, Halifax, Canada; 5Health Sciences North Research Institute, Sudbury, Ontario, CanadaCorrespondence: Melissa K AndrewDepartment of Medicine, Division of Geriatric Medicine, Dalhousie University, Veterans Memorial Building, 5955, Veterans Memorial Lane, Halifax, NS, B3H 2E1, CanadaTel +1 902 473-4995Email mandrew@dal.caAbstract: The COVID-19 pandemic has disproportionately impacted frail older adults, especially residents of long-term care (LTC) facilities. This has appropriately led to prioritization of frail older adults and LTC residents, and those who care for them, in the vaccination effort against COVID-19. Older adults have distinct immunological, clinical, and practical complexity, which can be understood through a lens of frailty. Even so, frailty has not been considered in studies of COVID-19 vaccines to date, leading to concerns that the vaccines have not been optimally tailored for and evaluated in this population even as vaccination programs are being implemented. This is an example of how vaccines are often not tested in Phase 1/2/3 clinical trials in the people most in need of protection. We argue that geriatricians, as frailty specialists, have much to contribute to the development, testing and implementation of COVID-19 vaccines in older adults. We discuss roles for geriatricians in ten stages of the vaccine development process, covering vaccine design, trial design, trial recruitment, establishment and interpretation of illness definitions, safety monitoring, consideration of relevant health measures such as frailty and function, analysis methods to account for frailty and differential vulnerability, contributions in regulatory and advisory roles, post-marketing surveillance, and program implementation and public health messaging. In presenting key recommendations pertinent to each stage, we hope to contribute to a dialogue on how to push the field of vaccinology to embrace the complexity of frailty. Making vaccines that can benefit frail older adults will benefit everyone in the fight against COVID-19.Keywords: SARS-CoV-2, COVID-19, vaccine, frailty, frail elderly, geriatrics

Published
2021

48. Effectiveness of a nurse-led hospital-to-home transitional care intervention for older adults with multimorbidity and depressive symptoms: A pragmatic randomized controlled trial

Author

Markle-Reid, Maureen, primary, McAiney, Carrie, additional, Fisher, Kathryn, additional, Ganann, Rebecca, additional, Gauthier, Alain P., additional, Heald-Taylor, Gail, additional, McElhaney, Janet E., additional, McMillan, Fran, additional, Petrie, Penelope, additional, Ploeg, Jenny, additional, Urajnik, Diana J., additional, and Whitmore, Carly, additional

Published
2021
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