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2. The impact of across-slope forest strips on hillslope subsurface hydrological dynamics

Author

Peskett, L, MacDonald, A, Heal, K, McDonnell, J, Chambers, J, Uhlemann, S, Upton, K, and Black, A

Subjects
Electrical resistivity tomography, Flooding, Forest strip, Groundwater, Runoff, Soil moisture, Environmental Engineering
Abstract

Forest cover has a significant effect on hillslope hydrological processes through its influence on the water balance and flow paths. However, knowledge of how spatial patterns of forest plots control hillslope hydrological dynamics is still poor. The aim of this study was to examine the impact of an across-slope forest strip on sub-surface soil moisture and groundwater dynamics, to give insights into how the structure and orientation of forest cover influences hillslope hydrology. Soil moisture and groundwater dynamics were compared on two transects spanning the same elevation on a 9° hillslope in a temperate UK upland catchment. One transect was located on improved grassland; the other was also on improved grassland but included a 14 m wide strip of 27-year-old mixed forest. Sub-surface moisture dynamics were investigated upslope, underneath and downslope of the forest over 2 years at seasonal and rainfall event timescales. Continuous data from point-based soil moisture sensors and piezometers installed at 0.15, 0.6 and 2.5 m depth were combined with seasonal (~bi-monthly) time-lapse electrical resistivity tomography (ERT) surveys. Significant differences were identified in sub-surface moisture dynamics underneath the forest strip over seasonal timescales: drying of the forest soils was greater, and extended deeper and for longer into the autumn compared to the adjacent grassland soils. Water table levels were also persistently lower in the forest and the forest soils responded less frequently to rainfall events. Downslope of the forest, soil moisture dynamics were similar to those in other grassland areas and no significant differences were observed beyond 15 m downslope, suggesting minimal impact of the forest at shallow depths downslope. Groundwater levels were lower downslope of the forest compared to other grassland areas, but during the wettest conditions there was evidence of upslope-downslope water table connectivity beneath the forest. The results indicate that forest strips in this environment provide only limited additional sub-surface storage of rainfall inputs in flood events after dry conditions in this temperate catchment setting.

Published
2020

3. Uncertainty Quantification and Propagation in Nuclear Density Functional Theory

Author

Schunck, N., McDonnell, J. D., Higdon, D., Sarich, J., and Wild, S. M.

Subjects
Nuclear Theory
Abstract

Nuclear density functional theory (DFT) is one of the main theoretical tools used to study the properties of heavy and superheavy elements, or to describe the structure of nuclei far from stability. While on-going efforts seek to better root nuclear DFT in the theory of nuclear forces [see Duguet et al., this issue], energy functionals remain semi-phenomenological constructions that depend on a set of parameters adjusted to experimental data in finite nuclei. In this paper, we review recent efforts to quantify the related uncertainties, and propagate them to model predictions. In particular, we cover the topics of parameter estimation for inverse problems, statistical analysis of model uncertainties and Bayesian inference methods. Illustrative examples are taken from the literature., Comment: Proceedings of the "Second International Workshop on Perspectives on Nuclear Data for the Next Decade", 14-17 October 2014, Bruy\`eres-le-Ch\^atel, France

Published
2015
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4. Uncertainty Quantification for Nuclear Density Functional Theory and Information Content of New Measurements

Author

McDonnell, J. D., Schunck, N., Higdon, D., Sarich, J., Wild, S. M., and Nazarewicz, W.

Subjects
Nuclear Theory
Abstract

Statistical tools of uncertainty quantification can be used to assess the information content of measured observables with respect to present-day theoretical models; to estimate model errors and thereby improve predictive capability; to extrapolate beyond the regions reached by experiment; and to provide meaningful input to applications and planned measurements. To showcase new opportunities offered by such tools, we make a rigorous analysis of theoretical statistical uncertainties in nuclear density functional theory using Bayesian inference methods. By considering the recent mass measurements from the Canadian Penning Trap at Argonne National Laboratory, we demonstrate how the Bayesian analysis and a direct least-squares optimization, combined with high-performance computing, can be used to assess the information content of the new data with respect to a model based on the Skyrme energy density functional approach. Employing the posterior probability distribution computed with a Gaussian process emulator, we apply the Bayesian framework to propagate theoretical statistical uncertainties in predictions of nuclear masses, two-neutron dripline, and fission barriers. Overall, we find that the new mass measurements do not impose a constraint that is strong enough to lead to significant changes in the model parameters. The example discussed in this study sets the stage for quantifying and maximizing the impact of new measurements with respect to current modeling and guiding future experimental efforts, thus enhancing the experiment-theory cycle in the scientific method., Comment: 5 pages, 4 figures, 1 table; Supplemental material with 2 tables; Submitted to Physical Review Letters

Published
2015
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5. Area excavations 1974–80 in and around Structure N

Author

Morris, Christopher D, primary, Emery, Norman, additional, Rains, Michael J, additional, Batey, Colleen E, additional, Young, Robert, additional, Hunter, John R, additional, Tylecote, Ronald F, additional, McDonnell, J Gerry, additional, Clogg, Philip, additional, Freeman, Claudine, additional, Rackham, James, additional, Nye, Sandra, additional, Allison, Enid P, additional, Colley, Sarah, additional, Owen, Moira, additional, Donaldson, Alison M, additional, and Outram, Zoe, additional

Published
2021
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6. Area excavations 1974–5 in and around Structure L and trial excavations in 1977 on features around Structure M

Author

Morris, Christopher D, primary, Emery, Norman, additional, Owen, Olwyn A, additional, Freeman, Claudine, additional, Batey, Colleen E, additional, Hunter, John R, additional, Rackham, D James, additional, Rains, Michael J, additional, Young, Robert, additional, Campbell, Ewan N, additional, Mills, Susan A, additional, McDonnell, J Gerry, additional, Allison, Enid P, additional, Colley, Sarah, additional, Nye, Sandra, additional, Donaldson, Alison M, additional, Owen, Moira, additional, and Outram, Zoe, additional

Published
2021
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7. Area excavations in 1977–81 on and around Structures ‘S’ and B to the west and north-west of the churchyard and re-assessment of the dating of Structures F, P and R to the north

Author

Morris, Christopher D, primary, Dalland, Magnar, additional, Owen, Olwyn A, additional, Rains, Michael J, additional, Batey, Colleen E, additional, Stevenson, Robert B K, additional, Bateson, Donal, additional, McDonnell, J Gerry, additional, Young, Robert, additional, Mills, Susan A, additional, Rackham, D James, additional, Colley, Sarah, additional, Donaldson, Alison M, additional, Nye, Sandra, additional, and Outram, Zoe, additional

Published
2021
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9. Area excavations 1976–80 in and around Structure E to the west of the churchyard

Author

Morris, Christopher D, primary, Rackham, D James, additional, Pearson, Nicholas F, additional, Batey, Colleen E, additional, Bateson, Donal, additional, Owen, Olwyn A, additional, McDonnell, J Gerry, additional, Forsyth, Katherine, additional, Young, Robert, additional, Campbell, Ewan N, additional, Mills, Susan A, additional, Colley, Sarah, additional, Donaldson, Alison M, additional, Nye, Sandra, additional, and Outram, Zoe, additional

Published
2021
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11. Nuclear Energy Density Optimization: UNEDF2

Author

Kortelainen, M., McDonnell, J., Nazarewicz, W., Olsen, E., Reinhard, P. -G., Sarich, J., Schunck, N., Wild, S. M., Davesne, D., Erler, J., and Pastore, A.

Subjects
Nuclear Theory
Abstract

The parameters of the UNEDF2 nuclear energy density functional (EDF) model were obtained in an optimization to experimental data consisting of nuclear binding energies, proton radii, odd-even mass staggering data, fission-isomer excitation energies, and single particle energies. In addition to parameter optimization, sensitivity analysis was done to obtain parameter uncertainties and correlations. The resulting UNEDF2 is an all-around EDF. However, the sensitivity analysis also demonstrated that the limits of current Skyrme-like EDFs have been reached and that novel approaches are called for., Comment: 6 pages, 2 figures. Talk given at the ARIS 2014 conference, Tokyo, Japan, June 1-6, 2014

Published
2014

12. Excitation energy dependence of fission in the mercury region

Author

McDonnell, J. D., Nazarewicz, W., Sheikh, J. A., Staszczak, A., and Warda, M.

Subjects
Nuclear Theory
Abstract

Background: Recent experiments on beta-delayed fission reported an asymmetric mass yield in the neutron-deficient nucleus 180Hg. Earlier experiments in the mass region A=190-200 close to the beta-stability line, using the (p,f) and (\alpha,f) reactions, observed a more symmetric distribution of fission fragments. While the beta-delayed fission of 180Hg can be associated with relatively low excitation energy, this is not the case for light-ion reactions, which result in warm compound nuclei. Purpose: To elucidate the roles of proton and neutron numbers and excitation energy in determining symmetric and asymmetric fission yields, we compute and analyze the isentropic potential energy surfaces of 174,180,198Hg and 196,210Po. Methods: We use the finite-temperature superfluid nuclear density functional theory, for excitation energies up to E*=30MeV and zero angular momentum. For our theoretical framework, we consider the Skyrme energy density functional SkM* and a density-dependent pairing interaction. Results: For 174,180Hg, we predict fission pathways consistent with asymmetric fission at low excitation energies, with the symmetric fission pathway opening very gradually as excitation energy is increased. For 198Hg and 196Po, we expect the nearly-symmetric fission channel to dominate. 210Po shows a preference for a slightly asymmetric pathway at low energies, and a preference for a symmetric pathway at high energies. Conclusions: Our self-consistent theory suggests that excitation energy weakly affects the fission pattern of the nuclei considered. The transition from the asymmetric fission in the proton-rich nuclei to a more symmetric fission in the heavier isotopes is governed by the shell structure of pre-scission configurations., Comment: 6 pages, 6 figures

Published
2014
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13. Quantification of Uncertainties in Nuclear Density Functional theory

Author

Schunck, N., McDonnell, J. D., Higdon, D., Sarich, J., and Wild, S.

Subjects
Nuclear Theory
Abstract

Reliable predictions of nuclear properties are needed as much to answer fundamental science questions as in applications such as reactor physics or data evaluation. Nuclear density functional theory is currently the only microscopic, global approach to nuclear structure that is applicable throughout the nuclear chart. In the past few years, a lot of effort has been devoted to setting up a general methodology to assess theoretical uncertainties in nuclear DFT calculations. In this paper, we summarize some of the recent progress in this direction. Most of the new material discussed here will be be published in separate articles., Comment: 4 pages, 2 figure; Proceedings of the International Workshop on Nuclear Data Covariances, April 28 - May 1, 2014, Santa Fe, New Mexico, USA - Second revised version after referee's comments

Published
2014

14. Nuclear energy density optimization: Shell structure

Author

Kortelainen, M., McDonnell, J., Nazarewicz, W., Olsen, E., Reinhard, P. -G., Sarich, J., Schunck, N., Wild, S. M., Davesne, D., Erler, J., and Pastore, A.

Subjects
Nuclear Theory
Abstract

Nuclear density functional theory is the only microscopical theory that can be applied throughout the entire nuclear landscape. Its key ingredient is the energy density functional. In this work, we propose a new parameterization UNEDF2 of the Skyrme energy density functional. The functional optimization is carried out using the POUNDerS optimization algorithm within the framework of the Skyrme Hartree-Fock-Bogoliubov theory. Compared to the previous parameterization UNEDF1, restrictions on the tensor term of the energy density have been lifted, yielding a very general form of the energy density functional up to second order in derivatives of the one-body density matrix. In order to impose constraints on all the parameters of the functional, selected data on single-particle splittings in spherical doubly-magic nuclei have been included into the experimental dataset. The agreement with both bulk and spectroscopic nuclear properties achieved by the resulting UNEDF2 parameterization is comparable with UNEDF1. While there is a small improvement on single-particle spectra and binding energies of closed shell nuclei, the reproduction of fission barriers and fission isomer excitation energies has degraded. As compared to previous UNEDF parameterizations, the parameter confidence interval for UNEDF2 is narrower. In particular, our results overlap well with those obtained in previous systematic studies of the spin-orbit and tensor terms. UNEDF2 can be viewed as an all-around Skyrme EDF that performs reasonably well for both global nuclear properties and shell structure. However, after adding new data aiming to better constrain the nuclear functional, its quality has improved only marginally. These results suggest that the standard Skyrme energy density has reached its limits and significant changes to the form of the functional are needed., Comment: 18 pages, 13 figures, 12 tables; resubmitted for publication to Phys. Rev. C after second review by referee

Published
2013
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15. Third minima in thorium and uranium isotopes in a self-consistent theory

Author

McDonnell, J. D., Nazarewicz, W., and Sheikh, J. A.

Subjects
Nuclear Theory
Abstract

Background: Deep third minima have been predicted in some non-self-consistent models to impact fission pathways of thorium and uranium isotopes. These predictions have guided the interpretation of resonances seen experimentally. On the other hand, self-consistent calculations consistently predict very shallow potential-energy surfaces in the third minimum region. Purpose: We investigate the interpretation of third-minimum configurations in terms of dimolecular states. We study the isentropic potential-energy surfaces of selected even-even thorium and uranium isotopes at several excitation energies. In order to understand the driving effects behind the presence of third minima, we study the interplay between pairing and shell effects. Methods: We use the finite-temperature superfluid nuclear density functional theory. We consider a traditional functional, SkM*, and a recent functional, UNEDF1, optimized for fission studies. Results: We predict very shallow or no third minima in the potential-energy surfaces of 232Th and 232U. In Th and U isotopes with N=136 and 138, the third minima are deeper. We show that the reflection-asymmetric configurations around the third minimum can be associated with dimolecular states involving the spherical doubly magic 132Sn and a lighter deformed Zr or Mo fragment. The potential-energy surfaces for 228,232Th and 232U at several excitation energies are presented. Conclusions: We show that the neutron shell effect that governs the existence of the dimolecular states around the third minimum is consistent with the spherical-to-deformed shape transition in the Zr and Mo isotopes around N=58. We demonstrate that the thermal reduction of pairing and enhancement of shell effects at small excitation energies help to develop deeper third minima. At large excitation energies, shell effects are washed out and third minima disappear altogether., Comment: 9 pages, 10 figures; published in Physical Review C

Published
2013
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16. Microscopic Description of Nuclear Fission: Fission Barrier Heights of Even-Even Actinides

Author

McDonnell, J., Schunck, N., and Nazarewicz, W.

Subjects
Nuclear Theory
Abstract

We evaluate the performance of modern nuclear energy density functionals for predicting inner and outer fission barrier heights and energies of fission isomers of even-even actinides. For isomer energies and outer barrier heights, we find that the self-consistent theory at the HFB level is capable of providing quantitative agreement with empirical data., Comment: 8 pages, 6 figures, 1 table; Proceedings of the 5th International Conference on "Fission and properties of neutron-rich nuclei" (ICFN5), Sanibel Island, Nov. 4-10, 2012

Published
2013
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17. Nuclear energy density optimization: Large deformations

Author

Kortelainen, M., McDonnell, J., Nazarewicz, W., Reinhard, P. -G., Sarich, J., Schunck, N., Stoitsov, M. V., and Wild, S. M.

Subjects
Nuclear Theory
Abstract

A new Skyrme-like energy density suitable for studies of strongly elongated nuclei has been determined in the framework of the Hartree-Fock-Bogoliubov theory using the recently developed model-based, derivative-free optimization algorithm POUNDerS. A sensitivity analysis at the optimal solution has revealed the importance of states at large deformations in driving the parameterization of the functional. The good agreement with experimental data on masses and separation energies, achieved with the previous parameterization UNEDF0, is largely preserved. In addition, the new energy density UNEDF1 gives a much improved description of the fission barriers in 240Pu and neighboring nuclei., Comment: 16 pages, 11 figures, accepted for publication in Phys. Rev. C

Published
2011
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18. Computing Heavy Elements

Author

Schunck, N., Baran, A., Kortelainen, M., McDonnell, J., Moré, J., Nazarewicz, W., Pei, J., Sarich, J., Sheikh, J., Staszczak, A., Stoitsov, M., and Wild, S. M.

Subjects
Nuclear Theory
Abstract

Reliable calculations of the structure of heavy elements are crucial to address fundamental science questions such as the origin of the elements in the universe. Applications relevant for energy production, medicine, or national security also rely on theoretical predictions of basic properties of atomic nuclei. Heavy elements are best described within the nuclear density functional theory (DFT) and its various extensions. While relatively mature, DFT has never been implemented in its full power, as it relies on a very large number (~ 10^9-10^12) of expensive calculations (~ day). The advent of leadership-class computers, as well as dedicated large-scale collaborative efforts such as the SciDAC 2 UNEDF project, have dramatically changed the field. This article gives an overview of the various computational challenges related to the nuclear DFT, as well as some of the recent achievements., Comment: Proceeding of the Invited Talk given at the SciDAC 2011 conference, Jul. 10-15, 2011, Denver, CO

Published
2011

19. Solution of the Skyrme-Hartree-Fock-Bogolyubov equations in the Cartesian deformed harmonic-oscillator basis. (VII) HFODD (v2.49t): a new version of the program

Author

Schunck, N., Dobaczewski, J., McDonnell, J., Satula, W., Sheikh, J. A., Staszczak, A., Stoitsov, M., and Toivanen, P.

Subjects
Nuclear Theory
Abstract

We describe the new version (v2.49t) of the code HFODD which solves the nuclear Skyrme Hartree-Fock (HF) or Skyrme Hartree-Fock-Bogolyubov (HFB) problem by using the Cartesian deformed harmonic-oscillator basis. In the new version, we have implemented the following physics features: (i) the isospin mixing and projection, (ii) the finite temperature formalism for the HFB and HF+BCS methods, (iii) the Lipkin translational energy correction method, (iv) the calculation of the shell correction. A number of specific numerical methods have also been implemented in order to deal with large-scale multi-constraint calculations and hardware limitations: (i) the two-basis method for the HFB method, (ii) the Augmented Lagrangian Method (ALM) for multi-constraint calculations, (iii) the linear constraint method based on the approximation of the RPA matrix for multi-constraint calculations, (iv) an interface with the axial and parity-conserving Skyrme-HFB code HFBTHO, (v) the mixing of the HF or HFB matrix elements instead of the HF fields. Special care has been paid to using the code on massively parallel leadership class computers. For this purpose, the following features are now available with this version: (i) the Message Passing Interface (MPI) framework, (ii) scalable input data routines, (iii) multi-threading via OpenMP pragmas, (iv) parallel diagonalization of the HFB matrix in the simplex breaking case using the ScaLAPACK library. Finally, several little significant errors of the previous published version were corrected., Comment: Accepted for publication to Computer Physics Communications. Program files re-submitted to Comp. Phys. Comm. Program Library after correction of several minor bugs

Published
2011
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20. One-quasiparticle States in the Nuclear Energy Density Functional Theory

Author

Schunck, N., Dobaczewski, J., McDonnell, J., More, J., Nazarewicz, W., Sarich, J., and Stoitsov, M. V.

Subjects
Nuclear Theory
Abstract

We study one-quasiproton excitations in the rare-earth region in the framework of the nuclear Density Functional Theory in the Skyrme-Hartree-Fock-Bogoliubov variant. The blocking prescription is implemented exactly, with the time-odd mean field fully taken into account. The equal filling approximation is compared with the exact blocking procedure. We show that both procedures are strictly equivalent when the time-odd channel is neglected, and discuss how nuclear alignment properties affect the time-odd fields. The impact of time-odd fields on calculated one-quasiproton bandhead energies is found to be rather small, of the order of 100-200 keV; hence, the equal filling approximation is sufficiently precise for most practical applications. The triaxial polarization of the core induced by the odd particle is studied. We also briefly discuss the occurrence of finite-size spin instabilities that are present in calculations for odd-mass nuclei when certain Skyrme functionals are employed., Comment: Accepted for publication in Phys. Rev. C after third report from the referee. One reference fixed

Published
2009
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21. Three years of Ulysses dust data: 2005 to 2007

Author

Krüger, Harald, Dikarev, V., Anweiler, B., Dermott, S. F., Graps, A. L., Gruen, E., Gustafson, B. A., Hamilton, D. P., Hanner, M. S., Horanyi, M., Kissel, J., Linkert, D., Linkert, G., Mann, I., McDonnell, J. A. M., Morfill, G. E., Polanskey, C., Schwehm, G., and Srama, R.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

The Ulysses spacecraft has been orbiting the Sun on a highly inclined ellipse since it encountered Jupiter in February 1992. Since then it made almost three revolutions about the Sun. Here we report on the final three years of data taken by the on-board dust detector. During this time, the dust detector recorded 609 dust impacts of particles with masses 10^-16 g <= m <= 10^-7 g, bringing the mission total to 6719 dust data sets. The impact rate varied from a low value of 0.3 per day at high ecliptic latitudes to 1.5 per day in the inner solar system. The impact direction of the majority of impacts between 2005 and 2007 is compatible with particles of interstellar origin, the rest are most likely interplanetary particles. We compare the interstellar dust measurements from 2005/2006 with the data obtained during earlier periods (1993/1994) and (1999/2000) when Ulysses was traversing the same spatial region at southern ecliptic latitudes but the solar cycle was at a different phase. During these three intervals the impact rate of interstellar grains varied by more than a factor of two. Furthermore, in the two earlier periods the grain impact direction was in agreement with the flow direction of the interstellar helium while in 2005/2006 we observed a shift in the approach direction of the grains by approximately 30 deg away from the ecliptic plane. The reason for this shift remains unclear but may be connected with the configuration of the interplanetary magnetic field during solar maximum. We also find that the dust measurements are in agreement with the interplanetary flux model of Staubach et al. (1997) which was developed to fit a 5-year span of Ulysses data., Comment: 50 pages, 9 b/w Figures, 1 colour figure, 4 Tables; submitted to Planetary and Space Science

Published
2009
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22. Galileo dust data from the jovian system: 2000 to 2003

Author

Krüger, Harald, Bindschadler, D., Dermott, S. F., Graps, A. L., Gruen, E., Gustafson, B. A., Hamilton, D. P., Hanner, M. S., Horanyi, M., Kissel, J., Linkert, D., Linkert, G., Mann, I., McDonnell, J. A. M., Moissl, R., Morfill, G. E., Polanskey, C., Roy, M., Schwehm, G., and Srama, R.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

The Galileo spacecraft was orbiting Jupiter between Dec 1995 and Sep 2003. The Galileo dust detector monitored the jovian dust environment between about 2 and 370 R_J (jovian radius R_J = 71492 km). We present data from the Galileo dust instrument for the period January 2000 to September 2003. We report on the data of 5389 particles measured between 2000 and the end of the mission in 2003. The majority of the 21250 particles for which the full set of measured impact parameters (impact time, impact direction, charge rise times, charge amplitudes, etc.) was transmitted to Earth were tiny grains (about 10 nm in radius), most of them originating from Jupiter's innermost Galilean moon Io. Their impact rates frequently exceeded 10 min^-1. Surprisingly large impact rates up to 100 min^-1 occurred in Aug/Sep 2000 when Galileo was at about 280 R_J from Jupiter. This peak in dust emission appears to coincide with strong changes in the release of neutral gas from the Io torus. Strong variability in the Io dust flux was measured on timescales of days to weeks, indicating large variations in the dust release from Io or the Io torus or both on such short timescales. Galileo has detected a large number of bigger micron-sized particles mostly in the region between the Galilean moons. A surprisingly large number of such bigger grains was measured in March 2003 within a 4-day interval when Galileo was outside Jupiter's magnetosphere at approximately 350 R_J jovicentric distance. Two passages of Jupiter's gossamer rings in 2002 and 2003 provided the first actual comparison of in-situ dust data from a planetary ring with the results inferred from inverting optical images., Comment: 59 pages, 13 figures, 6 tables, submitted to Planetary and Space Science

Published
2009
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28. GEO debris and interplanetary dust: fluxes and charging behavior

Author

Graps, Amara L., Green, Simon F., McBride, Neil, McDonnell, J. A. M., Bunte, Kalle, Svedhem, Hakan, and Drolshagen, Gerhard

Subjects
Astrophysics
Abstract

In September 1996, a dust/debris detector: GORID was launched into the geostationary (GEO) region as a piggyback instrument on the Russian Express-2 telecommunications spacecraft. The instrument began its normal operation in April 1997 and ended its mission in July 2002. The goal of this work was to use GORID's particle data to identify and separate the space debris to interplanetary dust particles (IDPs) in GEO, to more finely determine the instrument's measurement characteristics and to derive impact fluxes. While the physical characteristics of the GORID impacts alone are insufficient for a reliable distinction between debris and interplanetary dust, the temporal behavior of the impacts are strong enough indicators to separate the populations based on clustering. Non-cluster events are predominantly interplanetary, while cluster events are debris. The GORID mean flux distributions (at mass thresholds which are impact speed dependent) for IDPs, corrected for dead time, are 1.35x10^{-4} m^{-2} s^{-1} using a mean detection rate: 0.54 d^{-1}, and for space debris are 6.1x10^{-4} m^{-2} s^{-1} using a mean detection rate: 2.5 d^{-1}. Beta-meteoroids were not detected. Clusters could be a closely-packed debris cloud or a particle breaking up due to electrostatic fragmentation after high charging., Comment: * Comments: 6 pages, 4 postscript figures, in Dust in Planetary Systems 2005, Krueger, H. and Graps, A. eds., ESA Publications, SP in press (2006). For high resolution version, see: http://www.mpi-hd.mpg.de/dustgroup/~graps/dips2005/GrapsetalDIPS2005.pdf

Published
2006

30. One year of Galileo dust data from the Jovian system: 1996

Author

Krüger, H., Grün, E., Graps, A., Bindschadler, D., Dermott, S., Fechtig, H., Gustason, B. A., Hamilton, D. P., Hanner, M. S., Horányi, M., Kissel, J., Lindblad, B. A., Linkert, D., Linkert, G., Mann, I., McDonnell, J. A. M., Morfill, G. E., Planskey, C., Schwehm, G., Srama, R., and Zook, H. A.

Subjects
Astrophysics
Abstract

The dust detector system onboard Galileo records dust impacts in circumjovian space since the spacecraft has been injected into a bound orbit about Jupiter in December 1995. This is the sixth in a series of papers dedicated to presenting Galileo and Ulysses dust data. We present data from the Galileo dust instrument for the period January to December 1996 when the spacecraft completed four orbits about Jupiter (G1, G2, C3 and E4). Data were obtained as high resolution realtime science data or recorded data during a time period of 100 days, or via memory read-outs during the remaining times. Because the data transmission rate of the spacecraft is very low, the complete data set (i. e. all parameters measured by the instrument during impact of a dust particle) for only 2% (5353) of all particles detected could be transmitted to Earth; the other particles were only counted. Together with the data for 2883 particles detected during Galileo's interplanetary cruise and published earlier, complete data of 8236 particles detected by the Galileo dust instrument from 1989 to 1996 are now available. The majority of particles detected are tiny grains (about 10 nm in radius) originating from Jupiter's innermost Galilean moon Io. These grains have been detected throughout the Jovian system and the highest impact rates exceeded $\rm 100 min^{-1}$. A small number of grains has been detected in the close vicinity of the Galilean moons Europa, Ganymede and Callisto which belong to impact-generated dust clouds formed by (mostly submicrometer sized) ejecta from the surfaces of the moons (Kr\"uger et al., Nature, 399, 558, 1999). Impacts of submicrometer to micrometer sized grains have been detected thoughout the Jovian system and especially in the region between the Galilean moons., Comment: accepted for Planetary and Space Science, 33 pages, 6 tables, 10 figures

Published
2001
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31. Four years of Ulysses dust data: 1996 to 1999

Author

Krüger, H., Grün, E., Landgraf, M., Dermott, S., Fechtig, H., Gustafson, B. A., Hamilton, D. P., Hanner, M. S., Horányi, M., Kissel, J., Lindblad, B. A., Linkert, D., Linkert, G., Mann, I., McDonnell, J. A. M., Morfill, G. E., Polanskey, C., Schwehm, G., Srama, R., and Zook, H. A.

Subjects
Astrophysics
Abstract

The Ulysses spacecraft is orbiting the Sun on a highly inclined ellipse ($ i = 79^{\circ}$, perihelion distance 1.3 AU, aphelion distance 5.4 AU). Between January 1996 and December 1999 the spacecraft was beyond 3 AU from the Sun and crossed the ecliptic plane at aphelion in May 1998. In this four-year period 218 dust impacts were recorded with the dust detector on board. We publish and analyse the complete data set of both raw and reduced data for particles with masses $\rm 10^{-16} g$ to $\rm 10^{-8}$ g. Together with 1477 dust impacts recorded between launch of Ulysses and the end of 1995 published earlier \cite{gruen1995c,krueger1999b}, a data set of 1695 dust impacts detected with the Ulysses sensor between October 1990 and December 1999 is now available. The impact rate measured between 1996 and 1999 was relatively constant with about 0.2 impacts per day. The impact direction of the majority of the impacts is compatible with particles of interstellar origin, the rest are most likely interplanetary particles. The observed impact rate is compared with a model for the flux of interstellar dust particles. The flux of particles several micrometers in size is compared with the measurements of the dust instruments on board Pioneer 10 and Pioneer 11 beyond 3 AU (Humes 1980, JGR, 85, 5841--5852, 1980). Between 3 and 5 AU, Pioneer results predict that Ulysses should have seen five times more ($\rm \sim 10 \mu m$ sized) particles than actually detected., Comment: accepted by Planetary and Space Science, 22 pages, 8 figures (1 colour figure)

Published
2001
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34. Three years of Galileo dust data: II. 1993 to 1995

Author

Krüger, H., Grün, E., Hamilton, D. P., Baguhl, M., Dermott, S., Fechtig, H., Gustafson, B. A., Hanner, M. S., Horányi, M., Kissel, J., Lindblad, B. A., Linkert, D., Linkert, G., Mann, I., McDonnell, J. A. M., Morfill, G. E., Polanskey, C., Riemann, R., Schwehm, G., Srama, R., and Zook, H. A.

Subjects
Astrophysics
Abstract

Between Jan 1993 and Dec 1995 the Galileo spacecraft traversed interplanetary space between Earth and Jupiter and arrived at Jupiter on 7 Dec 1995. The dust instrument onboard was operating during most of the time. A relatively constant impact rate of interplanetary and interstellar (big) particles of 0.4 impacts per day was detected over the whole three-year time span. In the outer solar system (outside about 2.6 AU) they are mostly of interstellar origin, whereas in the inner solar system they are mostly interplanetary particles. Within about 1.7 AU from Jupiter intense streams of small dust particles were detected with impact rates of up to 20,000 per day whose impact directions are compatible with a Jovian origin. Two different populations of dust particles were detected in the Jovian magnetosphere: small stream particles during Galileo's approach to the planet and big particles concentrated closer to Jupiter between the Galilean satellites. There is strong evidence that the dust stream particles are orders of magnitude smaller in mass and faster than the instrument's calibration, whereas the calibration is valid for the big particles. Because the data transmission rate was very low, the complete data set for only a small fraction (2525) of all detected particles could be transmitted to Earth; the other particles were only counted. Together with the 358 particles published earlier, information about 2883 particles detected by the dust instrument during Galileo's six years' journey to Jupiter is now available., Comment: Accepted for Planetary and Space Science, 37 pages, 5 tables, 13 figures

Published
1998
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35. Three years of Ulysses dust data: 1993 to 1995

Author

Krüger, H., Grün, E., Landgraf, M., Baguhl, M., Dermott, S., Fechtig, H., Gustafson, B. A., Hamilton, D. P., Hanner, M. S., Horányi, M., Kissel, J., Lindblad, B. A., Linkert, D., Linkert, G., Mann, I., McDonnell, J. A. M., Morfill, G. E., Polanskey, C., Schwehm, G., Srama, R., and Zook, H. A.

Subjects
Astrophysics
Abstract

The Ulysses spacecraft is orbiting the Sun on a highly inclined ellipse ($i = 79^{\circ}$). After its Jupiter flyby in 1992 at a heliocentric distance of 5.4 AU, the spacecraft reapproached the inner solar system, flew over the Sun's south polar region in September 1994, crossed the ecliptic plane at a distance of 1.3 AU in March 1995, and flew over the Sun's north polar region in July 1995. We report on dust impact data obtained with the dust detector onboard Ulysses between January 1993 and December 1995. We publish and analyse the complete data set of 509 recorded impacts of dust particles with masses between $10^{-16}$ g to $10^{-7}$ g. Together with 968 dust impacts from launch until the end of 1992 published earlier (Gr\"un et al., 1995, {\em Planet. Space Sci}, Vol. 43, p. 971-999), information about 1477 particles detected with the Ulysses sensor between October 1990 and December 1995 is now available. The impact rate measured between 1993 and 1995 stayed relatively constant at about 0.4 impacts per day and varied by less than a factor of ten. Most of the impacts recorded outside about 3.5 AU are compatible with particles of interstellar origin. Two populations of interplanetary particles have been recognised: big micrometer-sized particles close to the ecliptic plane and small sub-micrometer-sized particles at high ecliptic latitudes. The observed impact rate is compared with a model for the flux of interstellar dust particles which gives relatively good agreement with the observed impact rate. No change in the instrument's noise characteristics or degradation of the channeltron could be revealed during the three-year period., Comment: 35 pages, 8 figures, 3 Tables, rotating package and Latex 2e required

Published
1998

38. Impact of the relative supply of glucose and oxygen on yeast kinetic activity

Author

McDonnell, J. L.

Subjects
572.492
Abstract

The objective of this project was to investigate the effects of the relative supplies of oxygen and glucose on the kinetic activity of the yeast Saccharomyces cerevisiae NCYC 1026. This study was initiated from observing yeast cells immobilised in the silicone rubber matrix material, immobaSil which has the property of high solubility of oxygen, reported to be eight times that of oxygen in water. Hence, would exposure of the yeast, as free cells, during storage to relatively higher or lower supplies of oxygen to glucose, lead to detrimental and irreversible changes in the kinetic activity of the yeast cells? By identifying the effects of storage conditions on yeast kinetic activity, suggestions could made as to how best to store yeast cell lines so as to promote desired levels of kinetic activity, i.e. to engineer the yeast cells to respond manner in industrial bioreaction applications, and to be able to predict the performance of immobilized cells. The yeast cells were stored as several different lines (Master Lines) which were exposed to varying supplies of oxygen and glucose during storage. Using aseptic handling techniques, these Master Lines were kept successfully for up to 1000 days continuous storage. From time to time, samples of yeast from these Master Lines were taken to produce an inoculum for free cell aerobic batch culture experiments, (Batch Runs), carried in a Stirred Tank Fermenter (STF). These batch culture experiments were conducted mainly under the initial conditions of 1000 mg/l glucose in a chemically defined liquid medium, an aeration rate of 41/min, (1 vvm), a temperature of 25oC and pH 4.5. The variations in the relative supplies of glucose and oxygen to yeast cells during storage time did appear to promote changes in kinetic activity, both detrimental and advantageous to industrial applications, which are identified in this study. The conclusions and observations made on this research have direct relevance to industrial applications and the development of predictable kinetic activity of yeast cells.

Published
1999

42. GARFIELD-AF: risk profiles, treatment patterns and 2-year outcomes in patients with atrial fibrillation in Germany, Austria and Switzerland (DACH) compared to 32 countries in other regions worldwide

Author

Sylvia, H, John A, C, Darius, H, Jan, S, Saverio, V, Karen, P, Marianne, B, Sebastian, S, Frank, M, Gloria, K, Kakkar, A, Bassand, J, John Camm, A, Fitzmaurice, D, Fox, K, Gersh, B, Goldhaber, S, Goto, S, Haas, S, Hacke, W, Mantovani, L, Misselwitz, F, Pieper, K, Turpie, A, van Eickels, M, Verheugt, F, Gersh, K, Lucas Luciardi Harry Gibbs, H, Brodmann, M, Cools, F, Carlos Pereira Barretto, A, Connolly, S, Eikelboom, J, Corbalan, R, Jing, Z, Jansky, P, Dalsgaard Nielsen, J, Ragy, H, Raatikainen, P, Le Heuzey, J, Keltai, M, Pal Singh Sawhney, J, Agnelli, G, Ambrosio, G, Koretsune, Y, Jerjes Sánchez Díaz, C, Ten Cate, H, Atar, D, Stepinska, J, Panchenko, E, Wei Lim, T, Jacobson, B, Oh, S, Viñolas, X, Rosenqvist, M, Steffel, J, Angchaisuksiri, P, Oto, A, Parkhomenko, A, Al Mahmeed, W, Hu Kangning Chen, D, Zhao, Y, Zhang, H, Chen, J, Cao, S, Wang, D, Yang, Y, Li, W, Li, H, Yin, Y, Tao, G, Yang, P, Chen, Y, He, S, Wang, Y, Fu, G, Li, X, Wu, T, Cheng, X, Yan, X, Zhao, R, Chen, M, Xiong, L, Chen, P, Jiao, Y, Guo, Y, Xue, L, Yang, Z, Jadhavm Raghava Sarma, P, Kulkarni, G, Chandwani, P, Atulbhai Pothiwala, R, Padinhare Purayil, M, Chawla, K, Annasaheb Kothiwale, V, Raghuraman, B, Madan Vijan, V, Sawhney, J, Bantwal, G, Khan, A, Meena, R, Chopada, M, Abraham, S, Bisne, V, Vijayaraghavan, G, Roy, D, Durgaprasad, R, Ravi Shankar, A, Kumar, S, Jain, D, Bhargava, K, Kumar, V, Madappa Nagamalesh, U, Kumar Rajput, R, Koretsune Seishu Kanamori, Y, Yamamoto, K, Kumagai, K, Katsuda, Y, Yoshida, K, Toyota, F, Mizuno, Y, Misumi, I, Noguchi, H, Ando, S, Suetsugu, T, Minamoto, M, Oda, H, Adachi, S, Chiba, K, Norita, H, Tsuruta, M, Koyanagi, T, Ando, H, Higashi, T, Okada, M, Azakami, S, Komaki, S, Kumeda, K, Murayama, T, Matsumura, J, Oba, Y, Sonoda, R, Goto, K, Minoda, K, Haraguchi, Y, Suefuji, H, Miyagi, H, Kato, H, Nakamura, T, Nandate, H, Zaitsu, R, Fujiura, Y, Yoshimura, A, Numata, H, Ogawa, J, Kamogawa, Y, Murakami, K, Wakasa, Y, Yamasawa, M, Maekawa, H, Abe, S, Kihara, H, Tsunoda, S, Saito, K, Tachibana, H, Oba, I, Kuwahata, T, Higa, S, Gushiken, M, Eto, T, Chibana, H, Fujisawa, K, Shiga, Y, Sumi, H, Nagatomo, T, Atsuchi, Y, Nagoshi, T, Sanno, K, Hoshino, F, Yokota, N, Kameko, M, Tabuchi, T, Ishizawa, M, Ikeda, D, Seto, T, Iwao, T, Ishioka, N, Oshiro, K, Tsuchida, K, Hatori, Y, Takeuchi, M, Takezawa, H, Nagano, S, Iwaki, M, Nakamura, Y, Miyamoto, N, Taguchi, T, Ashida, K, Yoshizawa, N, Agata, J, Matsukawa, S, Arasaki, O, Fukuoka, S, Murakami, H, Mishima, K, Hata, Y, Sakuma, I, Obunai, K, Takamura, I, Akutsu, M, Unoki, T, Go, Y, Ikemura, M, Morii, S, Marusaki, S, Doi, H, Tanaka, M, Kusumoto, T, Kakinoki, S, Ogurusu, C, Murata, K, Shimoyama, M, Nakatsuka, M, Kitami, Y, Oyama, R, Ageta, M, Mita, T, Nagao, K, Mito, T, Minami, J, Abe, M, Fujii, M, Okawa, M, Fujito, T, Taniguchi, T, Ko, T, Kubo, H, Imamaki, M, Akiyama, M, Ueda, T, Odakura, H, Inagaki, M, Katsube, Y, Nakata, A, Tomimoto, S, Shibuya, M, Nakano, M, Ito, K, Matsuta, M, Ishiguro, M, Minagawa, T, Wada, M, 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Rikimaru Oyama, Masato Ageta, Teruaki Mita, Kazuhiko Nagao, Takafumi Mito, Junichi Minami, Mitsunori Abe, Masako Fujii, Makoto Okawa, Tsuneo Fujito, Toshiya Taniguchi, Tenei Ko, Hiroshi Kubo, Mizuho Imamaki, Masahiro Akiyama, Takashi Ueda, Hironori Odakura, Masahiko Inagaki, Yoshiki Katsube, Atsuyuki Nakata, Shinobu Tomimoto, Mitsuhiro Shibuya, Masayuki Nakano, Kenichiro Ito, Masahiro Matsuta, Motoyuki Ishiguro, Taro Minagawa, Masamichi Wada, Hiroaki Mukawa, Masato Mizuguchi, Fumio Okuda, Teruaki Kimura, Kuniaki Taga, Masaaki Techigawara, Morio Igarashi, Hiroshi Watanabe, Toshihiko Seo, Shinya Hiramitsu, Hiroaki Hosokawa, Mitsumoto Hoshiai, Michitaka Hibino, Koichi Miyagawa, Hideki Horie, Nobuyoshi Sugishita, Yukio Shiga, Akira Soma, Kazuo Neya, Tetsuro Yoshida, Kunio Akahane, Sen Adachi, Chiei Takanaka, Saori Matsui, Hirofumi Kanda, Masanori Kaneko, Shiro Nagasaka, Atsushi Taguchi, Shuta Toru, Kazuyuki Saito, Akiko Miyashita, Hiroki Sasaguri, Jin Nariyama, Taketo Hatsuno, Takash Iwase, Kazuki Sato, Kazuya Kawai, Tomobumi Kotani, Tsuyoshi Tsuji, Hirosumi Sakai, Kiyoshi Nishino, Kenichi Ikeda, Kazuo Maeda, Tomohiro Shinozuka, Takeshi Inoue, Koichi Kawakami, Hiromichi Kitazumi, Tsutomu Takagi, Mamoru Hamaoka, Jisho Kojima, Akitoshi Sasaki, Yoshihiro Tsuchiya, Tetsuo Betsuyaku, Koji Higuchi, Masaaki Honda, Koichi Hasegawa, Takao Baba, Kazuaki Mineoi, Toshihiko Koeda, Kunihiko Hirasawa, Toshihide Kumazaki, Akira Nakagomi, Eiji Otaki, Takashi Shindo, Hiroyoshi Hirayama, Chikako Sugimoto, Takashi Yamagishi, Ichiro Mizuguchi, Kazunori Sezaki, Isamu Niwa, Ken Takenaka, Osamu Iiji, Koichi Taya, Hitoshi Kitazawa, samu Ueda, Hirokazu Kakuda, Takuya Ono, Seizo Oriso, Junya Kamata, Toshihiko Nanke, Itaru Maeda, Yoshifusa Matsuura, Hiroki Teragawa, Yasuyuki Maruyama, Kazuo Takei, Hajime Horie, Tetsutaro Kito, Hiroshi Asano, Koji Matsushita, Masaichi Nakamura, Takashi Washizuka, Tomoki Yoshida, Masato Sawano, Shinichi Arima, Hidekazu Arai, Hisanori Shinohara, Hiroyuki Takai, Nobufusa Furukawa, Akira Ota, Kentaro Yamamoto, Kenji Aoki, Taku Yamamoto, Takeaki Kasai, Shunji Suzuki, Shu Suzuki, Nitaro Shibata, Masayuki Watanabe, Yosuke Nishihata, Toru Arino, Masaki Okuyama, Tetsushi Wakiyama, Tomoko Kato, Yasuo Sasagawa, Takeshi Tana, Yoshihito Hayashi, Shinichi Hirota, Yukihiko Abe, Yoshihiro Saito, Hirohide Uchiyama, Hiroshi Takeda, Hiroshi Ono, Shuichi Tohyo, Naoto Hanazono, Seiichi Miyajima, Hisashi Shimono, Takuma Aoyama, Yasunobu Shozawa, Yawara Niijima, Osamu Murai, Hideko Inaba, Katsumasa Nomura, Masatsugu Nozoe, Kazuo Suzuki, Toshiyuki Furukawa, Toshihiko Shiraiwa, Nobuhisa Ito, Shunichi Nagai, Kiyoharu Sato, Shiro Nakahara, Yujin Shimoyama, Naoko Ohara, Teruhiko Kozuka, Hideaki Okita, Masato Endo, Tsutomu Goto, Makoto Hirose, Emiko Nagata, Noriyuki Nakanishi, Toshizumi Mori, Shuichi Seki, Katsuhiro Okamoto, Osamu Moriai, Yoko Emura, Tsuyoshi Fukuda, Haruhiko Date, Shuichi Kawakami, Sho Nagai, Yuya Ueyama, Tetsuro Fudo, Mitsuru Imaizumi, Takuo Ogawa, Shunsuke Take, Hideo Ikeda, Hiroaki Nishioka, Norihiko Sakamoto, Kiyomitsu Ikeoka, Nobuo Wakaki, Masatake Abe, Junji Doiuchi, Tetsuya Kira, Masato Tada, Ken Tsuzaki, Naoya Miura, Yasuaki Fujisawa, Wataru Furumoto, Susumu Suzuki, Akinori Fujisawa, Ryosai Nakamura, Hiroyasu Komatsu, Rei Fujiki, Shuichi Kawano, Keijiro Nishizawa, Yoji Kato, Junya Azuma, Kiyoshi Yasui, Toshio Amano, Yasuhiro Sekine, Tatsuo Honzawa, Yuichiro Koshibu, Yasuhide Sakamoto, Yukihiro Seta, Shingo Miyaguchi, Kojuro Morishita, Yasuko Samejima, Toyoshi Sasaki, Fumiko Iseki, Toshiyuki Kobayashi, Hiroshi Kano, Jaeyoung Kim, Hiroshi Yamaguchi, Yoichi Takagi, Yoko Onuki Pearce, Yasuyuki Suzuki, Takayuki Fukui, Toru Nakayama, Hideaki Kanai, Yoshiyuki Kawano, Tetsuji Ino, Hironori Miyoshi, Yasufumi Miyamoto, Masahito Shigekiyo, Shimato Ono, Yutaka Okamoto, Satoshi Ubukata, Kojiro Kodera, Tatsuo Oriuchi, Naoki Matsumoto, Koichi Inagaki, Atsushi Iseki, Tomohiro Yoshida, Toshihiro Goda, Tsukasa Katsuki, Atsushi Sato, Etsuo Mori, Toshio Tsubokura, Hiroshi Shudo, Shunichi Fujimoto, Tomohiro Katsuya, Yoshiyuki Furukawa, Hiroshi Hosokawa, Jun Narumi, Kiichiro Yamamoto, Masaki Owari, Takuya Inakura, Takafumi Anno, Kazuyuki Shirakawa, Chi Keong Ching Toon Wei Lim, David Foo, Kelvin Wong, Tan Yuyang, Seil Oh Hui Nam Park, Woo-Shik Kim, HyeYoung Lee, Sung-Won Jang, Dae Hyeok Kim, Jun Kim, DongRyeol Ryu, Jaemin Shim, Dae-Kyeong Kim, Dong Ju Choi, Yong Seog Oh, Myeong-Chan Cho, Hack-Lyoung Kim, Hui-Kyung Jeon, Dong-Gu Shin, Sang Weon Park, Hoon Ki Park, Sang-Jin Han, Jung Hoon Sung, Hyung-Wook Park, Gi-Byoung Nam, Young Keun On, Hong Euy Lim, JaeJin Kwak, Tae-Joon Cha, Taek Jong Hong, Seong Hoon Park, Jung Han Yoon, Nam-Ho Kim, Kee-Sik Kim, Byung Chun Jung, Gyo-Seung Hwang, Chong-Jin Kim, Sakda Rungaramsin Peerapat Katekangplu, Porames Khunrong, Thanita Bunyapipat, Wanwarang Wongcharoen, Pinij Kaewsuwanna, Khanchai Siriwattana, Waraporn Tiyanon, Supalerk Pattanaprichakul, Khanchit Likittanasombat, Doungrat Cholsaringkarl, Warangkana Boonyapisit, Sirichai Cheewatanakornkul, Songkwan Silaruks, Pisit Hutayanon, Seksan Chawanadelert, Pairoj Chattranukulchai, Boonsert Chatlaong, Yingsak Santanakorn, Khompiya Kanokphatcharakun, Piya Mongkolwongroj, Sasivimon Jai-Aue, Ongkarn Komson, Armagan Altun Ali Aydinlar, Ramazan Topsakal, Zeki Ongen, Sadik Acikel, Durmus Yildiray Sahin, Ozcan Yilmaz, Mehmet Birhan Yilmaz, Hasan Pekdemir, Mesut Demir, Murat Sucu, Levent Sahiner, Murat Ersanli, Ertugrul Okuyan, Dursun Aras, Florencia Rolandi Adrian Cesar Ingaramo, Gustavo Alberto Sambadaro, Vanina Fernandez Caputi, Hector Luciardi, Sofia Graciela Berman, Pablo Dragotto, Andres Javier Kleiban, Nestor Centurion, Rodolfo Andres Ahuad Guerrero, Leonel Adalberto Di Paola, Ricardo Dario Dran, Javier Egido, Matias Jose Fosco, Victor Alfredo Sinisi, Luis Rodolfo Cartasegna, Oscar Gomez Vilamajo, Jose Luis Ramos, Sonia Sassone, Gerardo Zapata, Diego Conde, Guillermo Giacomi, Alberto Alfredo Fernandez, Mario Alberto Berli, Fabian Ferroni, Dário Celestino Sobral Filho Jefferson Jaber, Luciana Vidal Armaganijan, Costantino Roberto Frack Costantini, André Steffens, Weimar Kunz Sebba Barroso de Souzaem, João David de Souza Neto, José Márcio Ribeiro, Marcelo Silveira Teixeira, Paulo Rossi, Leonardo Pires, Daniel Moreira, José Carlos Moura Jorge, Adalberto Menezes Lorga Filho, Luiz Bodanese, Marcelo Westerlund Montera, Carlos Henrique Del Carlo, Jamil Abdalla Saad, Fernando Augusto Alves da Costa, Renato Lopes, Gilson Roberto de Araújo, Euler Roberto Manenti, Jose Francisco Kerr Saraiva, João Carlos Ferreira Braga, Alexandre Negri, Carlos Moncada, Dalton Precoma, Fernando Roquette, Gilmar Reis, Roberto Álvaro Ramos Filho, Estêvão Lanna Figueiredo, Roberto Vieira Botelho, Cláudio Munhoz da Fontoura Tavares, Helius Carlos Finimundi, Adriano Kochi, César Cássio Broilo França, Fábio Alban, Guido Bernardo Aranha Rosito, João Batista de Moura Xavier Moraes Junior, Rogério Tadeu Tumelero, Lilia Maia, Roberto 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Briones, Jose Luis Leiva Pons, Humberto Alvarez Lopez, Rafael Olvera Ruiz, Carlos Gerardo Cantu Brito, Eduardo Julian Jose Roberto Chuquiure Valenzuela, Roxana Reyes Sanchez, Alberto Esteban Bazzoni Ruiz, Oscar Martin Lopez Ruiz, Roberto Arriaga Nava, Jesus David Morales Cerda, Pedro Fajardo Campos, Mario Benavides Gonzalez, Marianne Brodmann Kurt Lenz, Claus Hagn, Johannes Foechterle, Heinz Drexel, Kurt Huber, Andrea Podczeck-Schweighofer, Michael Winkler, Bruno Schneeweiss, Alfons Gegenhuber, Wilfried Lang, Sabine Eichinger-Hasenauer, Peter Kaserer, Josef Sykora, Heribert Rasch, Bernhard Strohmer, Luc Capiau Geert Vervoort, Bart Wollaert, Geert Hollanders, Jan Vercammen, Dirk Faes, Yohan Balthazar, Marc Delforge, Olivier Xhaet, Harry Striekwold, John Thoeng, Kurt Hermans, Georges Mairesse, Wim Anné, Ivan Blankoff, Michel Beutels, Stefan Verstraete, Peter Vandergoten, Philippe Purnode, Pascal Godart, Tim Boussy, Philippe Desfontaines, Alex Heyse, Joeri Voet, Axel De Wolf, Eva Zidkova 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Ravi Shankar, Sunil Kumar, Dinesh Jain, Kartikeya Bhargava, Vinay Kumar, Udigala Madappa Nagamalesh, Rajeeve Kumar Rajput, Yukihiro Koretsune Seishu Kanamori, Kenichi Yamamoto, Koichiro Kumagai, Yosuke Katsuda, Keiki Yoshida, Fumitoshi Toyota, Yuji Mizuno, Ikuo Misumi, Hiroo Noguchi, Shinichi Ando, Tetsuro Suetsugu, Masahiro Minamoto, Hiroyuki Oda, Susumu Adachi, Kei Chiba, Hiroaki Norita, Makoto Tsuruta, Takeshi Koyanagi, Kunihiko Yamamoto, Hiroshi Ando, Takayuki Higashi, Megumi Okada, Shiro Azakami, Shinichiro Komaki, Kenshi Kumeda, Takashi Murayama, Jun Matsumura, Yurika Oba, Ryuji Sonoda, Kazuo Goto, Kotaro Minoda, Yoshikuni Haraguchi, Hisakazu Suefuji, Hiroo Miyagi, Hitoshi Kato, Tsugihiro Nakamura, Tadashi Nakamura, Hidekazu Nandate, Ryuji Zaitsu, Yoshihisa Fujiura, Akira Yoshimura, Hiroyuki Numata, Jun Ogawa, Yasuyuki Kamogawa, Kinshiro Murakami, Yutaka Wakasa, Masanori Yamasawa, Hiromitsu Maekawa, Sumihisa Abe, Hajime Kihara, Satoru Tsunoda, Katsumi Saito, Hiroki Tachibana, Ichiro Oba, Takashi Kuwahata, Satoshi Higa, Masamichi Gushiken, Takuma Eto, Hidetoshi Chibana, Kazuaki Fujisawa, Yuhei Shiga, Hirokuni Sumi, Toshihisa Nagatomo, Yoshihiko Atsuchi, Toshiro Nagoshi, Kazuhisa Sanno, Fumihiro Hoshino, Naoto Yokota, Masahiro Kameko, Toshifumi Tabuchi, Munesumi Ishizawa, Yoshitake Fujiura, Daisuke Ikeda, Taku Seto, Tetsu Iwao, Norio Ishioka, Koichi Oshiro, Keizo Tsuchida, Yutaka Hatori, Motoshi Takeuchi, Hiroto Takezawa, Shinjiro Nagano, Masaaki Iwaki, Yuichiro Nakamura, Naomasa Miyamoto, Toshifumi Taguchi, Ko Ashida, Naoto Yoshizawa, Jun Agata, Seishiro Matsukawa, Osamu Arasaki, Shuji Fukuoka, Hirofumi Murakami, Kazuya Mishima, Yoshiki Hata, Ichiro Sakuma, Kotaro Obunai, Ichiro Takamura, Mitsuyuki Akutsu, Toshihide Unoki, Yoshinori Go, Makoto Ikemura, Shoji Morii, Shigeru Marusaki, Hideo Doi, Mitsuru Tanaka, Takaaki Kusumoto, Shigeo Kakinoki, Chiga Ogurusu, Kazuya Murata, Masaki Shimoyama, Masami Nakatsuka, Yutaka Kitami, Yoichi Nakamura, Hiroshi Oda, 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Iwase, Kazuki Sato, Kazuya Kawai, Tomobumi Kotani, Tsuyoshi Tsuji, Hirosumi Sakai, Kiyoshi Nishino, Kenichi Ikeda, Kazuo Maeda, Tomohiro Shinozuka, Takeshi Inoue, Koichi Kawakami, Hiromichi Kitazumi, Tsutomu Takagi, Mamoru Hamaoka, Jisho Kojima, Akitoshi Sasaki, Yoshihiro Tsuchiya, Tetsuo Betsuyaku, Koji Higuchi, Masaaki Honda, Koichi Hasegawa, Takao Baba, Kazuaki Mineoi, Toshihiko Koeda, Kunihiko Hirasawa, Toshihide Kumazaki, Akira Nakagomi, Eiji Otaki, Takashi Shindo, Hiroyoshi Hirayama, Chikako Sugimoto, Takashi Yamagishi, Ichiro Mizuguchi, Kazunori Sezaki, Isamu Niwa, Ken Takenaka, Osamu Iiji, Koichi Taya, Hitoshi Kitazawa, samu Ueda, Hirokazu Kakuda, Takuya Ono, Seizo Oriso, Junya Kamata, Toshihiko Nanke, Itaru Maeda, Yoshifusa Matsuura, Hiroki Teragawa, Yasuyuki Maruyama, Kazuo Takei, Hajime Horie, Tetsutaro Kito, Hiroshi Asano, Koji Matsushita, Masaichi Nakamura, Takashi Washizuka, Tomoki Yoshida, Masato Sawano, Shinichi Arima, Hidekazu Arai, Hisanori Shinohara, Hiroyuki Takai, Nobufusa Furukawa, Akira Ota, Kentaro Yamamoto, Kenji Aoki, Taku Yamamoto, Takeaki Kasai, Shunji Suzuki, Shu Suzuki, Nitaro Shibata, Masayuki Watanabe, Yosuke Nishihata, Toru Arino, Masaki Okuyama, Tetsushi Wakiyama, Tomoko Kato, Yasuo Sasagawa, Takeshi Tana, Yoshihito Hayashi, Shinichi Hirota, Yukihiko Abe, Yoshihiro Saito, Hirohide Uchiyama, Hiroshi Takeda, Hiroshi Ono, Shuichi Tohyo, Naoto Hanazono, Seiichi Miyajima, Hisashi Shimono, Takuma Aoyama, Yasunobu Shozawa, Yawara Niijima, Osamu Murai, Hideko Inaba, Katsumasa Nomura, Masatsugu Nozoe, Kazuo Suzuki, Toshiyuki Furukawa, Toshihiko Shiraiwa, Nobuhisa Ito, Shunichi Nagai, Kiyoharu Sato, Shiro Nakahara, Yujin Shimoyama, Naoko Ohara, Teruhiko Kozuka, Hideaki Okita, Masato Endo, Tsutomu Goto, Makoto Hirose, Emiko Nagata, Noriyuki Nakanishi, Toshizumi Mori, Shuichi Seki, Katsuhiro Okamoto, Osamu Moriai, Yoko Emura, Tsuyoshi Fukuda, Haruhiko Date, Shuichi Kawakami, Sho Nagai, Yuya Ueyama, Tetsuro Fudo, Mitsuru Imaizumi, Takuo Ogawa, 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Mori, Toshio Tsubokura, Hiroshi Shudo, Shunichi Fujimoto, Tomohiro Katsuya, Yoshiyuki Furukawa, Hiroshi Hosokawa, Jun Narumi, Kiichiro Yamamoto, Masaki Owari, Takuya Inakura, Takafumi Anno, Kazuyuki Shirakawa, Chi Keong Ching Toon Wei Lim, David Foo, Kelvin Wong, Tan Yuyang, Seil Oh Hui Nam Park, Woo-Shik Kim, HyeYoung Lee, Sung-Won Jang, Dae Hyeok Kim, Jun Kim, DongRyeol Ryu, Jaemin Shim, Dae-Kyeong Kim, Dong Ju Choi, Yong Seog Oh, Myeong-Chan Cho, Hack-Lyoung Kim, Hui-Kyung Jeon, Dong-Gu Shin, Sang Weon Park, Hoon Ki Park, Sang-Jin Han, Jung Hoon Sung, Hyung-Wook Park, Gi-Byoung Nam, Young Keun On, Hong Euy Lim, JaeJin Kwak, Tae-Joon Cha, Taek Jong Hong, Seong Hoon Park, Jung Han Yoon, Nam-Ho Kim, Kee-Sik Kim, Byung Chun Jung, Gyo-Seung Hwang, Chong-Jin Kim, Sakda Rungaramsin Peerapat Katekangplu, Porames Khunrong, Thanita Bunyapipat, Wanwarang Wongcharoen, Pinij Kaewsuwanna, Khanchai Siriwattana, Waraporn Tiyanon, Supalerk Pattanaprichakul, Khanchit Likittanasombat, Doungrat 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Berli, Fabian Ferroni, Dário Celestino Sobral Filho Jefferson Jaber, Luciana Vidal Armaganijan, Costantino Roberto Frack Costantini, André Steffens, Weimar Kunz Sebba Barroso de Souzaem, João David de Souza Neto, José Márcio Ribeiro, Marcelo Silveira Teixeira, Paulo Rossi, Leonardo Pires, Daniel Moreira, José Carlos Moura Jorge, Adalberto Menezes Lorga Filho, Luiz Bodanese, Marcelo Westerlund Montera, Carlos Henrique Del Carlo, Jamil Abdalla Saad, Fernando Augusto Alves da Costa, Renato Lopes, Gilson Roberto de Araújo, Euler Roberto Manenti, Jose Francisco Kerr Saraiva, João Carlos Ferreira Braga, Alexandre Negri, Carlos Moncada, Dalton Precoma, Fernando Roquette, Gilmar Reis, Roberto Álvaro Ramos Filho, Estêvão Lanna Figueiredo, Roberto Vieira Botelho, Cláudio Munhoz da Fontoura Tavares, Helius Carlos Finimundi, Adriano Kochi, César Cássio Broilo França, Fábio Alban, Guido Bernardo Aranha Rosito, João Batista de Moura Xavier Moraes Junior, Rogério Tadeu Tumelero, Lilia Maia, Roberto Simões de Almeida, Ney Carter do Carmo Borges, Luís Gustavo Gomes Ferreira, Ramón Corbalán Benjamin Aleck Joseh Stockins Fernandez, Humberto Montecinos, Fernando Lanas, Martín Larico Gómez, Carlos Astudillo, Carlos Conejeros, Patricio Marin Cuevas, Alejandro Forero, Claudio Bugueño Gutiérrez, Juan Aguilar, Sergio Potthoff Cardenas, German Eggers, Cesar Houzvic, Carlos Rey, Germán Arriagada, Gustavo Charme Vilches, Carlos Jerjes Sanchez Diaz Jesus Jaime Illescas Diaz, Raul Leal Cantu, Maria Guadalupe Ramos Zavala, Ricardo Cabrera Jardines, Nilda Espinola Zavaleta, Enrique Lopez Rosas, Guillermo Antonio Llamas Esperón, Gerardo Pozas, Ernesto Cardona Muñoz, Norberto Matadamas Hernandez, Adolfo Leyva Rendon, Norberto Garcia Hernandez, Manuel de los Rios Ibarra, Luis Ramon Virgen Carrillo, David Lopez Villezca, Carlos Hernandez Herrera, Juan Jose Lopez Prieto, Rodolfo Gaona Rodriguez, Efrain Villeda Espinosa, David Flores Martinez, Jose Velasco Barcena, Omar Fierro Fierro, Ignacio Rodriguez Briones, Jose Luis Leiva Pons, Humberto Alvarez Lopez, Rafael Olvera Ruiz, Carlos Gerardo Cantu Brito, Eduardo Julian Jose Roberto Chuquiure Valenzuela, Roxana Reyes Sanchez, Alberto Esteban Bazzoni Ruiz, Oscar Martin Lopez Ruiz, Roberto Arriaga Nava, Jesus David Morales Cerda, Pedro Fajardo Campos, Mario Benavides Gonzalez, Marianne Brodmann Kurt Lenz, Claus Hagn, Johannes Foechterle, Heinz Drexel, Kurt Huber, Andrea Podczeck-Schweighofer, Michael Winkler, Bruno Schneeweiss, Alfons Gegenhuber, Wilfried Lang, Sabine Eichinger-Hasenauer, Peter Kaserer, Josef Sykora, Heribert Rasch, Bernhard Strohmer, Luc Capiau Geert Vervoort, Bart Wollaert, Geert Hollanders, Jan Vercammen, Dirk Faes, Yohan Balthazar, Marc Delforge, Olivier Xhaet, Harry Striekwold, John Thoeng, Kurt Hermans, Georges Mairesse, Wim Anné, Ivan Blankoff, Michel Beutels, Stefan Verstraete, Peter Vandergoten, Philippe Purnode, Pascal Godart, Tim Boussy, Philippe Desfontaines, Alex Heyse, Joeri Voet, Axel De Wolf, Eva Zidkova Petr Jansky, Rudolf Spacek, Vilma Machova, Ondrej Ludka, Josef Olsr, Lubos Kotik, Blazej Racz, Richard Ferkl, Jan Hubac, Ilja Kotik, Zdenek Monhart, Hana Burianova, Ondrej Jerabek, Jana Pisova, Iveta Petrova, Vratislav Dedek, Michaela Honkova, Petr Podrazil, Petr Reichert, Jindrich Spinar, Miroslav Novak, Vaclav Durdil, Katarina Plocova, Jiri Lastuvka, Jørn Nielsen Steen Husted, Helena Dominguez, Ulrik Hintze, Søren Rasmussen, Næstved Sygehus, Arne Bremmelgaard, John Markenvard, Jan Børger, Jorgen Solgaard, Ebbe Eriksen, Thomas Løkkegaard, Michael Bruun, Jacob Mertz, Morten Schou, Michael Olsen, Pekka Raatikainen Carmela Viitanen, Franck Paganelli Joël Ohayon, Frédéric Casassus, Michel Galinier, Yannick Gottwalles, Philippe Loiselet, Jean-Joseph Muller, Mohamed Bassel Koujan, André Marquand, Sylvain Destrac, Olivier Piot, Nicolas Delarche, Jean-Pierre Cebron, Maxime Guenoun, Dominique Guedj-Meynier, A. G. Lokesh, Mathieu Zuber, Pierre Amarenco, Emmanuel Ellie, James Kadouch, Pierre-Yves Fournier, Jean-Pierre Huberman, Nestor Lemaire, Gilles Rodier, Xavier Vandamme, Igor Sibon, Jean-Philippe Neau, Marie Hélène Mahagne, Antoine Mielot, Marc Bonnefoy, Jean-Baptiste Churet, Vincent Navarre, Frederic Sellem, Gilles Monniot, Jean-Paul Boyes, Bernard Doucet, Michel Martelet, Désiré Obadia, Bernard Crousillat, Joseph Mouallem, Etienne Bearez, Jean Philippe Brugnaux, Alain Fedorowsky, Pierre Nazeyrollas, Jean-Baptiste Berneau, Frédéric Chemin, Sebastien Schellong Harald Darius, Georg Koeniger, Andreas Kopf, Uwe Gerbaulet, Bernd-Thomas Kellner, Thomas Schaefer, Jan Purr, Enno Eißfeller, Heinz-Dieter Zauzig, Peter Riegel, Christoph Axthelm, Gerd-Ulrich Heinz, Holger Menke, Andreas Pustelnik, Stefan Zutz, Wolfgang Eder, Guenter Rehling, Dirk Glatzel, Norbert Ludwig, Petra Sandow, Henning Wiswedel, Cosmas Wildenauer, Steffen Schoen, Toralf Schwarz, Adyeri Babyesiza, Maximilian Kropp, Hans-Hermann Zimny, Friedhelm Kahl, Andreas Caspar, Sabine Omankowsky, Torsten Laessig, Hermann-Josef Hartmann, Gunter Lehmann, Hans-Walter Bindig, Gunter Hergdt, Dietrich Reimer, Joachim Hauk, Holger Michel, Praxis Dres. 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Beer, Dipen Shah, Iurii Rudyk Vira Tseluyko, Oleksandr Karpenko, Svitlana Zhurba, Igor Kraiz, Oleksandr Parkhomenko, Iryna Kupnovytska, Nestor Seredyuk, Yuriy Mostovoy, Oleksiy Ushakov, Olena Koval, Igor Kovalskiy, Yevgeniya Svyshchenko, Oleg Sychov, Mykola Stanislavchuk, Andriy Yagensky, Susanna Tykhonova, Ivan Fushtey, Will Murdoch Naresh Chauhan, Daryl Goodwin, Louise Lumley, Ramila Patel, Philip Saunders, Bennett Wong, Alex Cameron, Niranjan Patel, P. Jhittay, Andrew Ross, M. S. Kainth, Karim Ladha, Kevin Douglas, Gill Pickavance, Joanna McDonnell, Laura Handscombe, Trevor Gooding, Helga Wagner, Colin Bradshaw, Catherine Bromham, Kevin Jones, Shoeb Suryani, Richard Coates, Bhupinder Sarai, W. Willcock, S. Sircar, John Cairns, A. Gilliand, Roman Bilas, E. Strieder, Peter Hutchinson, Anne Wakeman, Michael Stokes, Graham Kirby, Bhaskhar Vishwanathan, Nigel Bird, Paul Evans, M. Clark, John Bisatt, Jennifer Litchfield, E. Fisher, Tim Fooks, Richard Kelsall, Neil Paul, Elizabeth Alborough, Michael Aziz, C. Ramesh, Pete Wilson, Simon Franklin, Sue Fairhead, Julian Thompson, Hasan Chowan, Gary Taylor, Dawn Tragen, Matt Parfitt, Claire Seamark, Carolyn Paul, Mark Richardson, Angus Jefferies, Helen Sharp, Hywel Jones, Claire Giles, Matthew Bramley, Philip Williams, Jehad Aldegather, Simon Wetherell, William Lumb, Phil Evans, Frances Scouller, Neil Macey, Stephen Rogers, Yvette Stipp, Richard West, Philip Pinney, Paul Wadeson, John Matthews, Preeti Pandya, Andrew Gallagher, T. Railton, Emyr Davies, Jonathan McClure, Marc Jacobs, Claire Hutton, R. Thompson, Bijoy Sinha, Keith Butter, Susan Barrow, Helen Little, David Russell, Ulka Choudhary, Ikram Haq, Paul Ainsworth, Claire Jones, Phil Weeks, Jane Eden, Lisa Gibbons, Janet Glencross, Alison MacLeod, K. Poland, Conor Mulolland, A. Warke, Paul Conn, D. Burns, R. Smith, R. Kamath, Jonathan Webster, Ian Hodgins, Stephen Vercoe, Paul Roome, Hilary Pinnock, Jayesh Patel, Amar Ali, Nigel Hart, Richard Davies, Nigel De-Sousa, Catherine Neden, Mark Danielsen, Purnima Sharma, Sophia Galloway, Charlotte Hawkins, Raife Oliver, Martin Aylward, Mira Pattni, Gordon Irvine, Shahid Ahmad, Catherine Rothwell, Fiaz Choudhary, Sabrina Khalaque, Stephanie Short, Sharon Peters, Warwick Coulson, Neil Roberts, Amy Butler Steven Coates, Ben Ward, Daniel Jackson, Steve Walton, Diane Shepherd, Toh Wong, Mark Boon, Melanie Deacon, David Cornelius, Sarah Davies, Ben Frankel, Nick Hargreaves, Henry Choi, Jon Sumner, Tim Myhill, Salah Estifanos, Diane Geatch, Justin Wilkinson, Richard Veale, Karen Forshaw, Rob Hirst, Kashif Zaman, Catherine Liley, Rebecca Wastling, Paul McEleny, Andre Beattie, Philip Cooke, Mike Wong, Mark Pugsley, Chaminda Dooldeniya, Greg Rogers, James Bennett, Polly Jacobs, Rajesh Muvva, Matthew Adam, Robin Fox, Nicolas Thomas, Simon Cartwright, Rory Reed, Simon Randfield, Christine A’Court, Ann Flynn, Andrew Halpin, Simon Dobson, Louise Lomax, Minnal Nadaph, Iain Munro, Jane Goram, Helen Stoddart, Phil Simmons, John Shewring, Emma Bowen-Simpkins, Mark Rickenbach, Adam Blenkhorn Bhuwanendu Singh, Penny Astridge, William van Gaal, Walter Abhayaratna, Philip Thomson, Ron Lehman, Jens Kilian, David Coulshed, Andrei Catanchin, David Colquhoun, Hosen Kiat, David Eccleston, John French, Bronte Ayres, Peter Blombery, Thanh Phan, James Rogers, David O’Donnell, Sang Cheol Bae, Harry Gibbs, Patrick Carroll, Greg Starmer, Margaret Arstall, Maurits Binnekamp, Astin Lee, John Eikelboom Robert Luton, Milan Gupta, Amritanshu Shekhar Pandey, Stephen Cheung, Rolland Leader, Philippe Beaudry, Félix Ayala-Paredes, Joseph Berlingieri, John Heath, Germain Poirier, Miranda du Preez, Bradley Schweitzer, Reginald Nadeau, Ripple Dhillon, Tomasz Hruczkowski, Andrea Lavoie, Ratika Parkash, James Cha, Benoit Coutu, Paul MacDonald, Brian Ramjattan, Jorge Bonet, Saul Vizel, Paul Angaran, Sameh Fikry, Ahmed Mowafy Azza Katta, Mazen Tawfik, Moustafa Nawar, Mohamed Sobhy, Seif Kamal Abou Seif, Tarek Khairy, Ahmed Abd El-Aziz, Nasser Taha, Ashraf Reda, Atef Elbahry, Mohamed Setiha, Mohamed Gamal El Din, Magdi Elkhadem, Adel El-Etreby, David Kettles Junaid Bayat, Heidi Siebert, Adrian Horak, Ynez Kelfkens, Riaz Garda, Thayabran Pillay, Michele Guerra, Louis van Zyl, Hendrik Theron, Andrew Murray, Rikus Louw, Deon Greyling, Pindile Mntla, Siddique Ismail, Fayzal Ahmed, Johannes Engelbrecht, Shambu Maharajh, Wessel Oosthuysen, Rehana Loghdey, Veronica Ueckermann, Wael AlAl Mahmeed AbdullahNaeemi, Ghazi Yousef, Nooshin Bazargani, Munther AlOmairi, Rajan Maruthanayagam, Rupesh Singh, Ahmed Naguib, Mohamed Ibrahim, Amrish Agrawal, Mukesh Nathani, Ehab M. Esheiba, Adel Wassef, Rajeev Gupta, Michael Cox Scott Beach, Peter Duffy, Stephen Falkowski, Kevin Ferrick, Miguel Franco, W. Michael Kutayli, Annette Quick, Niraj Sharma, Vance Wilson, Stephen Miller, Mark Alberts, Edwin Blumberg, Roddy Canosa, Ted Gutowski, Rodney Ison, Jorge Garcia, Paul Mullen, Howard Noveck, Pamela Rama, Rajneesh Reddy, Marcus Williams, Daniel Nishijima, Keith Ferdinand, Ihsan Haque, Robert Mendelson, Sridevi Pitta, Daniel Theodoro, Charles Treasure, Moustafa Moustafa, Cas Cader, Walter Pharr, Alisha Oropallo, George Platt, Jaspal Gujral, James Welker, and Firas Koura

Abstract

Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is a worldwide non-interventional study of stroke prevention in patients with non-valvular AF. Methods and results: 52,080 patients with newly diagnosed AF were prospectively enrolled from 2010 to 2016. 4121 (7.9%) of these patients were recruited in DACH [Germany (n = 3567), Austria (n = 465) and Switzerland (n = 89) combined], and 47,959 patients were from 32 countries in other regions worldwide (ORW). Hypertension was most prevalent in DACH and ORW (85.3% and 75.6%, respectively). Diabetes, hypercholesterolaemia, carotid occlusive disease and vascular disease were more prevalent in DACH patients vs ORW (27.6%, 49.4%, 5.8% and 29.0% vs 21.7%, 40.9%, 2.8% and 24.5%). The use of non-vitamin K antagonist oral anticoagulants (NOACs) increased more in DACH over time. Management of vitamin K antagonists was suboptimal in DACH and ORW (time in therapeutic range of INR ≥ 65% in 44.6% and 44.4% of patients or ≥ 70% in 36.9% and 36.0% of patients, respectively). Adjusted rates of cardiovascular mortality and MI/ACS were higher in DACH while non-haemorrhagic stroke/systemic embolism was lower after 2-year follow-up. Conclusions: Similarities and dissimilarities in AF management and clinical outcomes are seen in DACH and ORW. The increased use of NOAC was associated with a mismatch of risk-adapted anticoagulation (over-and-undertreatment) in DACH. Suboptimal control of INR requires educational activities in both regional groups. Higher rates of cardiovascular death in DACH may reflect the higher risk profile of these patients and lower rates of non-haemorrhagic stroke could be associated with increased NOAC use. Graphical abstract: [Figure not available: see fulltext.].

Published
2023

44. AMPX Developments in FY2022 [Slides]

Author

McDonnell, J. D., primary, Brown, J., additional, Chapman, C., additional, Jeon, B. K., additional, Kim, K. S., additional, Wiarda, D., additional, and Holcomb, A., additional

Published
2023
Full Text
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46. Characterising catchment water storage under different land covers using multiple methods: Informing modelling and natural flood management

Author

Peskett, L., Heal, K., MacDonald, A., Collins, S., Black, A., and McDonnell, J.

Abstract

A key assumption of `natural flood management’ (NFM) and catchment restoration schemes is that land use is a major control of runoff. To assess the effectiveness of these schemes requires understanding of the influence of land use change on catchment water storage and mixing. However, few NFM schemes are resourced to also investigate the underpinning hydrological processes. This study combined hydrometric, isotopic and geochemical water properties to investigate land cover controls on catchment runoff and water storage in nine nested catchments within a 67 km2 managed upland catchment in southern Scotland, UK. Forest cover in the sub-catchments ranged from 0.5 to 94%.Sub-catchment dynamic storage characterised from hydrometric data using recession analysis was low but variable (16–200 mm). Mean transit times estimated from isotopic data were 134–370 days and groundwater fractions estimated from end member mixing analysis based on acid neutralising capacity (ANC) were 0.20–0.52 of annual stream runoff. Correlation of measures of catchment water storage and mixing with land cover, topographic, soil and geological catchment attributes showed significant positive correlations with soil hydraulic properties, whilst percentage forest cover was inversely correlated. The results highlight the importance of understanding dominant controls on water storage in target catchments when using tree planting as a flood management strategy. The isotopic and ANC data are also being integrated into hydrological modelling of the catchment to constrain the number of potential models and reduce model equifinality.

Published
2023

48. Dust measurements in the coma of comet 67P/Churyumov-Gerasimenko inbound to the Sun

Author

Rotundi, A., Sierks, H., Corte, V. Della, Fulle, M., Gutierrez, P. J., Lara, L., Barbieri, C., Lamy, P. L., Rodrigo, R., Koschny, D., Rickman, H., Keller, H. U., López-Moreno, J. J., Accolla, M., Agarwal, J., A'Hearn, M. F., Altobelli, N., Angrilli, F., Barucci, M. A., Bertaux, J.-L., Bertini, I., Bodewits, D., Bussoletti, E., Colangeli, L., Cosi, M., Cremonese, G., Crifo, J.-F., Da Deppo, V., Davidsson, B., Debei, S., De Cecco, M., Esposito, F., Ferrari, M., Fornasier, S., Giovane, F., Gustafson, B., Green, S. F., Groussin, O., Grün, E., Güttler, C., Herranz, M. L., Hviid, S. F., Ip, W., Ivanovski, S., Jerónimo, J. M., Jorda, L., Knollenberg, J., Kramm, R., Kührt, E., Küppers, M., Lazzarin, M., Leese, M. R., López-Jiménez, A. C., Lucarelli, F., Lowry, S. C., Marzari, F., Epifani, E. Mazzotta, McDonnell, J. A. M., Mennella, V., Michalik, H., Molina, A., Morales, R., Moreno, F., Mottola, S., Naletto, G., Oklay, N., Ortiz, J. L., Palomba, E., Palumbo, P., Perrin, J.-M., Rodríguez, J., Sabau, L., Snodgrass, C., Sordini, R., Thomas, N., Tubiana, C., Vincent, J.-B., Weissman, P., Wenzel, K.-P., Zakharov, V., and Zarnecki, J. C.

Published
2015

50. RECENT AMPX developments [Slides]

Author

McDonnell, J., primary, Brown, J., additional, Chapman, C., additional, Jeon, B., additional, Kim, K., additional, Wiarda, D., additional, and Holcomb, Andrew, additional

Published
2022
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