Search

Your search keyword '"McDonnell, Charles H"' showing total 23 results
Start Over Author "McDonnell, Charles H"
23 results on '"McDonnell, Charles H"'

2. Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ.

Author

Ding, Lina, Su, Ying, Fassl, Anne, Hinohara, Kunihiko, Qiu, Xintao, Harper, Nicholas W, Huh, Sung Jin, Bloushtain-Qimron, Noga, Jovanović, Bojana, Ekram, Muhammad, Zi, Xiaoyuan, Hines, William C, Alečković, Maša, Gil Del Alcazar, Carlos, Caulfield, Ryan J, Bonal, Dennis M, Nguyen, Quang-De, Merino, Vanessa F, Choudhury, Sibgat, Ethington, Gabrielle, Panos, Laura, Grant, Michael, Herlihy, William, Au, Alfred, Rosson, Gedge D, Argani, Pedram, Richardson, Andrea L, Dillon, Deborah, Allred, D Craig, Babski, Kirsten, Kim, Elizabeth Min Hui, McDonnell, Charles H, Wagner, Jon, Rowberry, Ron, Bobolis, Kristie, Kleer, Celina G, Hwang, E Shelley, Blum, Joanne L, Cristea, Simona, Sicinski, Piotr, Fan, Rong, Long, Henry W, Sukumar, Saraswati, Park, So Yeon, Garber, Judy E, Bissell, Mina, Yao, Jun, and Polyak, Kornelia

Subjects
Cell Line, Tumor, Animals, Humans, Mice, Carcinoma, Ductal, Breast, Tumor Suppressor Proteins, BRCA1 Protein, BRCA2 Protein, Transcription Factors, Fluorescent Antibody Technique, Immunohistochemistry, Cell Proliferation, Mutation, Germ-Line Mutation, Female, T Cell Transcription Factor 1, Cell Line, Tumor, Carcinoma, Ductal, Breast, Breast Cancer, Cancer, Prevention, Genetics, 2.1 Biological and endogenous factors, MD Multidisciplinary
Abstract

Myoepithelial cells play key roles in normal mammary gland development and in limiting pre-invasive to invasive breast tumor progression, yet their differentiation and perturbation in ductal carcinoma in situ (DCIS) are poorly understood. Here, we investigated myoepithelial cells in normal breast tissues of BRCA1 and BRCA2 germline mutation carriers and in non-carrier controls, and in sporadic DCIS. We found that in the normal breast of non-carriers, myoepithelial cells frequently co-express the p63 and TCF7 transcription factors and that p63 and TCF7 show overlapping chromatin peaks associated with differentiated myoepithelium-specific genes. In contrast, in normal breast tissues of BRCA1 mutation carriers the frequency of p63+TCF7+ myoepithelial cells is significantly decreased and p63 and TCF7 chromatin peaks do not overlap. These myoepithelial perturbations in normal breast tissues of BRCA1 germline mutation carriers may play a role in their higher risk of breast cancer. The fraction of p63+TCF7+ myoepithelial cells is also significantly decreased in DCIS, which may be associated with invasive progression.

Published
2019

3. Impact of cancer screening results on patient-reported outcomes (PRO) and behavioral intentions.

Author

Patrick, Donald, primary, Ross, Melissa, additional, Mulnick, Sarah, additional, Samuelson, Ashley, additional, Cong, Ze, additional, Chung, Karen, additional, Klein, Eric A., additional, Reid, Robert Lawrence, additional, Lopatin, Margarita, additional, Fung, Eric T., additional, Dilaveri, Christina A., additional, Marinac, Catherine, additional, and McDonnell, Charles H, additional

Published
2024
Full Text
View/download PDF

5. Data from Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition

Author

Gil Del Alcazar, Carlos R., primary, Huh, Sung Jin, primary, Ekram, Muhammad B., primary, Trinh, Anne, primary, Liu, Lin L., primary, Beca, Francisco, primary, Zi, Xiaoyuan, primary, Kwak, Minsuk, primary, Bergholtz, Helga, primary, Su, Ying, primary, Ding, Lina, primary, Russnes, Hege G., primary, Richardson, Andrea L., primary, Babski, Kirsten, primary, Min Hui Kim, Elizabeth, primary, McDonnell, Charles H., primary, Wagner, Jon, primary, Rowberry, Ron, primary, Freeman, Gordon J., primary, Dillon, Deborah, primary, Sorlie, Therese, primary, Coussens, Lisa M., primary, Garber, Judy E., primary, Fan, Rong, primary, Bobolis, Kristie, primary, Allred, D. Craig, primary, Jeong, Joon, primary, Park, So Yeon, primary, Michor, Franziska, primary, and Polyak, Kornelia, primary

Published
2023
Full Text
View/download PDF

6. Supplementary Figures 1 through 7, Supplementary Methods from Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition

Author

Gil Del Alcazar, Carlos R., primary, Huh, Sung Jin, primary, Ekram, Muhammad B., primary, Trinh, Anne, primary, Liu, Lin L., primary, Beca, Francisco, primary, Zi, Xiaoyuan, primary, Kwak, Minsuk, primary, Bergholtz, Helga, primary, Su, Ying, primary, Ding, Lina, primary, Russnes, Hege G., primary, Richardson, Andrea L., primary, Babski, Kirsten, primary, Min Hui Kim, Elizabeth, primary, McDonnell, Charles H., primary, Wagner, Jon, primary, Rowberry, Ron, primary, Freeman, Gordon J., primary, Dillon, Deborah, primary, Sorlie, Therese, primary, Coussens, Lisa M., primary, Garber, Judy E., primary, Fan, Rong, primary, Bobolis, Kristie, primary, Allred, D. Craig, primary, Jeong, Joon, primary, Park, So Yeon, primary, Michor, Franziska, primary, and Polyak, Kornelia, primary

Published
2023
Full Text
View/download PDF

7. Supplementary Tables 1 through 8 from Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition

Author

Gil Del Alcazar, Carlos R., primary, Huh, Sung Jin, primary, Ekram, Muhammad B., primary, Trinh, Anne, primary, Liu, Lin L., primary, Beca, Francisco, primary, Zi, Xiaoyuan, primary, Kwak, Minsuk, primary, Bergholtz, Helga, primary, Su, Ying, primary, Ding, Lina, primary, Russnes, Hege G., primary, Richardson, Andrea L., primary, Babski, Kirsten, primary, Min Hui Kim, Elizabeth, primary, McDonnell, Charles H., primary, Wagner, Jon, primary, Rowberry, Ron, primary, Freeman, Gordon J., primary, Dillon, Deborah, primary, Sorlie, Therese, primary, Coussens, Lisa M., primary, Garber, Judy E., primary, Fan, Rong, primary, Bobolis, Kristie, primary, Allred, D. Craig, primary, Jeong, Joon, primary, Park, So Yeon, primary, Michor, Franziska, primary, and Polyak, Kornelia, primary

Published
2023
Full Text
View/download PDF

11. The PATHFINDER Study: Assessment of the Implementation of an Investigational Multi-Cancer Early Detection Test into Clinical Practice

Author

Nadauld, Lincoln D., primary, McDonnell, Charles H., additional, Beer, Tomasz M., additional, Liu, Minetta C., additional, Klein, Eric A., additional, Hudnut, Andrew, additional, Whittington, Richard A., additional, Taylor, Bruce, additional, Oxnard, Geoffrey R., additional, Lipson, Jafi, additional, Lopatin, Margarita, additional, Shaknovich, Rita, additional, Chung, Karen C., additional, Fung, Eric T., additional, Schrag, Deborah, additional, and Marinac, Catherine R., additional

Published
2021
Full Text
View/download PDF

12. A prespecified interim analysis of the PATHFINDER study: Performance of a multicancer early detection test in support of clinical implementation.

Author

Beer, Tomasz M., primary, McDonnell, Charles H., additional, Nadauld, Lincoln, additional, Liu, Minetta C., additional, Klein, Eric A., additional, Reid, Robert Lawrence, additional, Chung, Karen, additional, Lopatin, Margarita, additional, Fung, Eric T., additional, and Schrag, Deborah, additional

Published
2021
Full Text
View/download PDF

14. Abstract CT291: The PATHFINDER Study: Assessment of the implementation of an investigational multi-cancer early detection test into clinical practice

Author

Nadauld, Lincoln, primary, McDonnell, Charles H., additional, Liu, Minetta C., additional, Klein, Eric, additional, Beer, Tomasz M., additional, Schrag, Deborah, additional, Hudnut, Andrew G., additional, Whittington, Richard, additional, Taylor, Bruce, additional, Tierney, Joanna, additional, Marinac, Catherine, additional, Lipson, Jafi, additional, Lopatin, Margarita, additional, Chung, Karen C., additional, Fung, Eric, additional, Hartman, Anne-Renee, additional, and Oxnard, Geoffrey R., additional

Published
2020
Full Text
View/download PDF

15. Abstract A15: Immune-related changes in breast cancer tumor evolution

Author

Alcazar, Carlos R. Gil del, primary, Huh, SungJin, additional, Ekram, Muhammad B., additional, Trinh, Anne, additional, Liu, Lin L., additional, Beca, Francisco, additional, Xiaoyuan, Zi, additional, Kwak, Misuk, additional, Bergholtz, Helga, additional, Su, Ying, additional, Ding, Lina, additional, Russnes, Hege G., additional, Richardson, Andrea L., additional, Babski, Kirsten, additional, Kim, Elizabeth Min Hui, additional, McDonnell, Charles H., additional, Wagner, Jon, additional, Rowberry, Ron, additional, Freeman, Gordon, additional, Dillon, Deborah, additional, Sorlie, Therese, additional, Coussens, Lisa M., additional, Garber, Judy E., additional, Fan, Rong, additional, Bobolis, Kristie, additional, Jeong, Joon, additional, Park, So Yeon, additional, Michor, Franziska, additional, and Polyak, Kornelia, additional

Published
2018
Full Text
View/download PDF

16. Abstract A21: Characterization of the immune environment in the in situ to invasive breast carcinoma transition

Author

Alcazar, Carlos R. Gil del, primary, Huh, SungJin, additional, Ekram, Muhammad B., additional, Trinh, Anne, additional, Liu, Lin L., additional, Beca, Francisco, additional, Xiaoyuan, Zi, additional, Kwak, Misuk, additional, Bergholtz, Helga, additional, Su, Ying, additional, Ding, Lina, additional, Russnes, Hege G., additional, Richardson, Andrea L., additional, Babski, Kirsten, additional, Kim, Elizabeth Min Hui, additional, McDonnell, Charles H., additional, Wagner, Jon, additional, Rowberry, Ron, additional, Freeman, Gordon J., additional, Dillon, Deborah, additional, Sorlie, Therese, additional, Coussens, Lisa M., additional, Garber, Judy E., additional, Fan, Rong, additional, Bobolis, Kristie, additional, Allred, D. Craig, additional, Jeong, Joon, additional, Park, So Yeon, additional, Michor, Franziska, additional, and Polyak, Kornelia, additional

Published
2018
Full Text
View/download PDF

17. Immune Escape in Breast Cancer During In Situ to Invasive Carcinoma Transition

Author

Gil Del Alcazar, Carlos R., primary, Huh, Sung Jin, additional, Ekram, Muhammad B., additional, Trinh, Anne, additional, Liu, Lin L., additional, Beca, Francisco, additional, Zi, Xiaoyuan, additional, Kwak, Minsuk, additional, Bergholtz, Helga, additional, Su, Ying, additional, Ding, Lina, additional, Russnes, Hege G., additional, Richardson, Andrea L., additional, Babski, Kirsten, additional, Min Hui Kim, Elizabeth, additional, McDonnell, Charles H., additional, Wagner, Jon, additional, Rowberry, Ron, additional, Freeman, Gordon J., additional, Dillon, Deborah, additional, Sorlie, Therese, additional, Coussens, Lisa M., additional, Garber, Judy E., additional, Fan, Rong, additional, Bobolis, Kristie, additional, Allred, D. Craig, additional, Jeong, Joon, additional, Park, So Yeon, additional, Michor, Franziska, additional, and Polyak, Kornelia, additional

Published
2017
Full Text
View/download PDF

21. CT of Fundoplication

Author

McDonnell, Charles H., primary, Baker, Mark E., additional, Cohan, Richard H., additional, Nadel, Scott N., additional, Leder, Richard A., additional, Pappas, Theodore N., additional, and Rice, Reed P., additional

Published
1991
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results