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5. Using pollen in turbidites for vegetation reconstructions.

Author

McDonald, Laura S., Strachan, Lorna J., Holt, Katherine, McArthur, Adam D., Barnes, Philip M., Maier, Katherine L., Orpin, Alan R., Horrocks, Mark, Ganguly, Aratrika, Hopkins, Jenni L., and Bostock, Helen C.

Subjects
PALYNOLOGY, POLLEN, MARINE sediments, TURBIDITES, SEDIMENT sampling
Abstract

Turbidites, deposited by sub‐aqueous gravity flows, are common in sedimentary archives worldwide and present a unique challenge and opportunity when reconstructing past vegetation through pollen analysis. When sampling pollen from a sediment core for palaeovegetation records, it is common practice to target background sediments (i.e. pelagic sediment) and avoid sampling turbidites, as they are presumed to portray a misleading picture of past vegetation. This assumption stems from our limited understanding of pollen abundance and distribution through turbidites, meaning that palynologists overlook deposits that could potentially be used to reconstruct past vegetation and climate. We present pollen assemblage and sedimentological data from four recent (<150 years) deep marine turbidite deposits from the Hikurangi Subduction Margin, Aotearoa‐New Zealand, with the aim of understanding the abundance and distribution of pollen in fine‐grained turbidites. We find that pollen is diluted in the bases of turbidites, but despite this dilution, the proportions of different pollen taxa remain consistent through each turbidite. These results confirm that pollen can be sampled from turbidites for palaeovegetation reconstructions and that sampling the fine‐grained upper parts of turbidites will provide the best pollen recovery. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Can video interaction guidance improve children's participation in group work lessons?

Author

McDonald, Laura Walmsley

Subjects
150
Abstract

Video Interaction Guidance (VIG) is an intervention that aims to improve communication and relationships. It is a video-based approach that involves a trained VIG professional filming, editing and reviewing film clips with a client, of their interactions with a significant other person. This thesis explores whether VIG can be used to improve pupils' participation in group work lessons, following a novel application of VIG in natural classroom settings. Study 1 aimed to determine whether there were improvements in video samples of observable classroom behaviour following VIG and to investigate participant experiences of the intervention. Participant evaluation of VIG, via focus groups, interviews and questionnaires, was positive. However, while Percentage of Data Points Exceeding the Mean (PEM) calculations of video data using a multiple baseline across participant small-N experimental design showed some degree of post-intervention changes, these were not statistically significant (p>.05) as indicated by Dugard and Todman's bootstrapped exact probability test (2011). Study 2 investigated whether the improvements reported by participants from Study 1 could be objectively observed by experienced professionals. A sample of 4 educational psychologists blind rated a random sample of pre- and post-intervention videos and identified post-intervention videos as evidencing significantly more effective examples of group work (p=.003). The criteria used in their clinical decision-making were used to inform a new video coding schedule. Re-coded observations from the sample of videos used in Study 1 were then analysed. Target pupils were found to be significantly more attentive and attuned to their peers after VIG (p=.05). While PEM scores of video data again indicated other post-intervention improvements, these were not statistically significant (p>.05). This study is unique in reporting objective, observable pupil behaviour change over the relatively short period of VIG intervention, with high levels of client satisfaction and acceptability. Methodological limitations and recommendations for future research are discussed together with key implications for practicing EPs.

Published
2015
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8. Chemokine Receptor 2 Is A Theranostic Biomarker for Abdominal Aortic Aneurysms

Author

Elizondo-Benedetto, Santiago, primary, Sastriques-Dunlop, Sergio, additional, Detering, Lisa, additional, Arif, Batool, additional, Heo, Gyu Seong, additional, Sultan, Deborah, additional, Luehmann, Hannah, additional, Zhang, Xiaohui, additional, Gao, Xuefeng, additional, Harrison, Kitty, additional, Thies, Dakkota, additional, McDonald, Laura, additional, Combadière, Christophe, additional, Lin, Chieh-Yu, additional, Kang, Yeona, additional, Zheng, Jie, additional, Ippolito, Joseph, additional, Laforest, Richard, additional, Gropler, Robert J., additional, English, Sean J., additional, Zayed, Mohamed A., additional, and Liu, Yongjian, additional

Published
2023
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13. Studies on the molecular bases of digit anatomy

Author

McDonald, Laura Ann

Subjects
612.646
Abstract

A fundamental problem in biology is how structures form in the correct place in developing embryos. The development of the vertebrate limb is a wonderful system in which to study such pattern formation. My PhD project has focussed specifically on how anatomically distinct digits form at different positions along the anteroposterior axis of the limb. Sonic hedgehog is known to be pivotal in determining the number and pattern of digits, but little is known about genes that are expressed in response to Shh to encode anteroposterior positional values, and how these positional values are interpreted into digit anatomy. I have taken two approaches to identify genes that could be involved in determining digit identity in the limb; one in which I use Drosophila wing vein patterning as a model, and the other microarrays.

Published
2008

14. Exploring the Health-Related Quality of Life of Patients Treated With Immune Checkpoint Inhibitors: Social Media Study

Author

Cotté, François-Emery, Voillot, Paméla, Bennett, Bryan, Falissard, Bruno, Tzourio, Christophe, Foulquié, Pierre, Gaudin, Anne-Françoise, Lemasson, Hervé, Grumberg, Valentine, McDonald, Laura, Faviez, Carole, and Schück, Stéphane

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundImmune checkpoint inhibitors (ICIs) are increasingly used to treat several types of tumors. Impact of this emerging therapy on patients’ health-related quality of life (HRQoL) is usually collected in clinical trials through standard questionnaires. However, this might not fully reflect HRQoL of patients under real-world conditions. In parallel, users’ narratives from social media represent a potential new source of research concerning HRQoL. ObjectiveThe aim of this study is to assess and compare coverage of ICI-treated patients’ HRQoL domains and subdomains in standard questionnaires from clinical trials and in real-world setting from social media posts. MethodsA retrospective study was carried out by collecting social media posts in French language written by internet users mentioning their experiences with ICIs between January 2011 and August 2018. Automatic and manual extractions were implemented to create a corpus where domains and subdomains of HRQoL were classified. These annotations were compared with domains covered by 2 standard HRQoL questionnaires, the EORTC QLQ-C30 and the FACT-G. ResultsWe identified 150 users who described their own experience with ICI (89/150, 59.3%) or that of their relative (61/150, 40.7%), with 137 users (91.3%) reporting at least one HRQoL domain in their social media posts. A total of 8 domains and 42 subdomains of HRQoL were identified: Global health (1 subdomain; 115 patients), Symptoms (13; 76), Emotional state (10; 49), Role (7; 22), Physical activity (4; 13), Professional situation (3; 9), Cognitive state (2; 2), and Social state (2; 2). The QLQ-C30 showed a wider global coverage of social media HRQoL subdomains than the FACT-G, 45% (19/42) and 29% (12/42), respectively. For both QLQ-C30 and FACT-G questionnaires, coverage rates were particularly suboptimal for Symptoms (68/123, 55.3% and 72/123, 58.5%, respectively), Emotional state (7/49, 14% and 24/49, 49%, respectively), and Role (17/22, 77% and 15/22, 68%, respectively). ConclusionsMany patients with cancer are using social media to share their experiences with immunotherapy. Collecting and analyzing their spontaneous narratives are helpful to capture and understand their HRQoL in real-world setting. New measures of HRQoL are needed to provide more in-depth evaluation of Symptoms, Emotional state, and Role among patients with cancer treated with immunotherapy.

Published
2020
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18. Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

Author

Mack, Stephen C., Pajtler, Kristian W., Chavez, Lukas, Okonechnikov, Konstantin, Bertrand, Kelsey C., Wang, Xiuxing, Erkek, Serap, Federation, Alexander, Song, Anne, Lee, Christine, Wang, Xin, McDonald, Laura, Morrow, James J., Saiakhova, Alina, Sin-Chan, Patrick, Wu, Qiulian, Michaelraj, Kulandaimanuvel Antony, Miller, Tyler E., Hubert, Christopher G., Ryzhova, Marina, Garzia, Livia, Donovan, Laura, Dombrowski, Stephen, Factor, Daniel C., Luu, Betty, Valentim, Claudia L. L., Gimple, Ryan C., Morton, Andrew, Kim, Leo, Prager, Briana C., Lee, John J. Y., Wu, Xiaochong, Zuccaro, Jennifer, Thompson, Yuan, Holgado, Borja L., Reimand, Jri, Ke, Susan Q., Tropper, Adam, Lai, Sisi, Vijayarajah, Senthuran, Doan, Sylvia, Mahadev, Vaidehi, Mian, Ana Fernandez, Grbner, Susanne N., Lienhard, Matthias, Zapatka, Marc, Huang, Zhiqin, Aldape, Kenneth D., Carcaboso, Angel M., Houghton, Peter J., Keir, Stephen T., Milde, Till, Witt, Hendrik, Li, Yan, Li, Chao-Jun, Bian, Xiu-Wu, Jones, David T. W., Scott, Ian, Singh, Sheila K., Huang, Annie, Dirks, Peter B., Bouffet, Eric, Bradner, James E., Ramaswamy, Vijay, Jabado, Nada, Rutka, James T., Northcott, Paul A., Lupien, Mathieu, Lichter, Peter, Korshunov, Andrey, Scacheri, Peter C., Pfister, Stefan M., Kool, Marcel, Taylor, Michael D., and Rich, Jeremy N.

Subjects
Gliomas -- Physiological aspects -- Genetic aspects -- Care and treatment, Cancer genetics -- Research, Cancer research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Stephen C. Mack [1, 2, 3, 4]; Kristian W. Pajtler [5, 6, 7]; Lukas Chavez [5, 6, 8]; Konstantin Okonechnikov [5, 6]; Kelsey C. Bertrand [1, 2, 9]; Xiuxing [...]

Published
2018
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22. Data from MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression

Author

Knight, John R.P., primary, Alexandrou, Constantinos, primary, Skalka, George L., primary, Vlahov, Nikola, primary, Pennel, Kathryn, primary, Officer, Leah, primary, Teodosio, Ana, primary, Kanellos, Georgios, primary, Gay, David M., primary, May-Wilson, Sebastian, primary, Smith, Ewan M., primary, Najumudeen, Arafath K., primary, Gilroy, Kathryn, primary, Ridgway, Rachel A., primary, Flanagan, Dustin J., primary, Smith, Rachael C.L., primary, McDonald, Laura, primary, MacKay, Craig, primary, Cheasty, Anne, primary, McArthur, Kerri, primary, Stanway, Emma, primary, Leach, Joshua D., primary, Jackstadt, Rene, primary, Waldron, Joseph A., primary, Campbell, Andrew D., primary, Vlachogiannis, Georgios, primary, Valeri, Nicola, primary, Haigis, Kevin M., primary, Sonenberg, Nahum, primary, Proud, Christopher G., primary, Jones, Neil P., primary, Swarbrick, Martin E., primary, McKinnon, Heather J., primary, Faller, William J., primary, Le Quesne, John, primary, Edwards, Joanne, primary, Willis, Anne E., primary, Bushell, Martin, primary, and Sansom, Owen J., primary

Published
2023
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23. Supplementary Data from MNK Inhibition Sensitizes KRAS-Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression

Author

Knight, John R.P., primary, Alexandrou, Constantinos, primary, Skalka, George L., primary, Vlahov, Nikola, primary, Pennel, Kathryn, primary, Officer, Leah, primary, Teodosio, Ana, primary, Kanellos, Georgios, primary, Gay, David M., primary, May-Wilson, Sebastian, primary, Smith, Ewan M., primary, Najumudeen, Arafath K., primary, Gilroy, Kathryn, primary, Ridgway, Rachel A., primary, Flanagan, Dustin J., primary, Smith, Rachael C.L., primary, McDonald, Laura, primary, MacKay, Craig, primary, Cheasty, Anne, primary, McArthur, Kerri, primary, Stanway, Emma, primary, Leach, Joshua D., primary, Jackstadt, Rene, primary, Waldron, Joseph A., primary, Campbell, Andrew D., primary, Vlachogiannis, Georgios, primary, Valeri, Nicola, primary, Haigis, Kevin M., primary, Sonenberg, Nahum, primary, Proud, Christopher G., primary, Jones, Neil P., primary, Swarbrick, Martin E., primary, McKinnon, Heather J., primary, Faller, William J., primary, Le Quesne, John, primary, Edwards, Joanne, primary, Willis, Anne E., primary, Bushell, Martin, primary, and Sansom, Owen J., primary

Published
2023
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24. Supplementary video 3 from A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Author

Birch, Joanna L., primary, Strathdee, Karen, primary, Gilmour, Lesley, primary, Vallatos, Antoine, primary, McDonald, Laura, primary, Kouzeli, Ariadni, primary, Vasan, Richa, primary, Qaisi, Abdulrahman Hussain, primary, Croft, Daniel R., primary, Crighton, Diane, primary, Gill, Kathryn, primary, Gray, Christopher H., primary, Konczal, Jennifer, primary, Mezna, Mokdad, primary, McArthur, Duncan, primary, Schüttelkopf, Alexander W., primary, McConnell, Patricia, primary, Sime, Mairi, primary, Holmes, William M., primary, Bower, Justin, primary, McKinnon, Heather J., primary, Drysdale, Martin, primary, Olson, Michael F., primary, and Chalmers, Anthony J., primary

Published
2023
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25. Data from RUNX1 Is a Driver of Renal Cell Carcinoma Correlating with Clinical Outcome

Author

Rooney, Nicholas, primary, Mason, Susan M., primary, McDonald, Laura, primary, Däbritz, J. Henry M., primary, Campbell, Kirsteen J., primary, Hedley, Ann, primary, Howard, Steven, primary, Athineos, Dimitris, primary, Nixon, Colin, primary, Clark, William, primary, Leach, Joshua D.G., primary, Sansom, Owen J., primary, Edwards, Joanne, primary, Cameron, Ewan R., primary, and Blyth, Karen, primary

Published
2023
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26. Data from A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Author

Birch, Joanna L., primary, Strathdee, Karen, primary, Gilmour, Lesley, primary, Vallatos, Antoine, primary, McDonald, Laura, primary, Kouzeli, Ariadni, primary, Vasan, Richa, primary, Qaisi, Abdulrahman Hussain, primary, Croft, Daniel R., primary, Crighton, Diane, primary, Gill, Kathryn, primary, Gray, Christopher H., primary, Konczal, Jennifer, primary, Mezna, Mokdad, primary, McArthur, Duncan, primary, Schüttelkopf, Alexander W., primary, McConnell, Patricia, primary, Sime, Mairi, primary, Holmes, William M., primary, Bower, Justin, primary, McKinnon, Heather J., primary, Drysdale, Martin, primary, Olson, Michael F., primary, and Chalmers, Anthony J., primary

Published
2023
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27. Supplemental Figures and Tables from Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

Author

Unbekandt, Mathieu, primary, Belshaw, Simone, primary, Bower, Justin, primary, Clarke, Maeve, primary, Cordes, Jacqueline, primary, Crighton, Diane, primary, Croft, Daniel R., primary, Drysdale, Martin J., primary, Garnett, Mathew J., primary, Gill, Kathryn, primary, Gray, Christopher, primary, Greenhalgh, David A., primary, Hall, James A.M., primary, Konczal, Jennifer, primary, Lilla, Sergio, primary, McArthur, Duncan, primary, McConnell, Patricia, primary, McDonald, Laura, primary, McGarry, Lynn, primary, McKinnon, Heather, primary, McMenemy, Carol, primary, Mezna, Mokdad, primary, Morrice, Nicolas A., primary, Munro, June, primary, Naylor, Gregory, primary, Rath, Nicola, primary, Schüttelkopf, Alexander W., primary, Sime, Mairi, primary, and Olson, Michael F., primary

Published
2023
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28. Supplementary Data from RUNX1 Is a Driver of Renal Cell Carcinoma Correlating with Clinical Outcome

Author

Rooney, Nicholas, primary, Mason, Susan M., primary, McDonald, Laura, primary, Däbritz, J. Henry M., primary, Campbell, Kirsteen J., primary, Hedley, Ann, primary, Howard, Steven, primary, Athineos, Dimitris, primary, Nixon, Colin, primary, Clark, William, primary, Leach, Joshua D.G., primary, Sansom, Owen J., primary, Edwards, Joanne, primary, Cameron, Ewan R., primary, and Blyth, Karen, primary

Published
2023
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29. Supplementary video figure legend from A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Author

Birch, Joanna L., primary, Strathdee, Karen, primary, Gilmour, Lesley, primary, Vallatos, Antoine, primary, McDonald, Laura, primary, Kouzeli, Ariadni, primary, Vasan, Richa, primary, Qaisi, Abdulrahman Hussain, primary, Croft, Daniel R., primary, Crighton, Diane, primary, Gill, Kathryn, primary, Gray, Christopher H., primary, Konczal, Jennifer, primary, Mezna, Mokdad, primary, McArthur, Duncan, primary, Schüttelkopf, Alexander W., primary, McConnell, Patricia, primary, Sime, Mairi, primary, Holmes, William M., primary, Bower, Justin, primary, McKinnon, Heather J., primary, Drysdale, Martin, primary, Olson, Michael F., primary, and Chalmers, Anthony J., primary

Published
2023
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30. Supplementary video 4 from A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Author

Birch, Joanna L., primary, Strathdee, Karen, primary, Gilmour, Lesley, primary, Vallatos, Antoine, primary, McDonald, Laura, primary, Kouzeli, Ariadni, primary, Vasan, Richa, primary, Qaisi, Abdulrahman Hussain, primary, Croft, Daniel R., primary, Crighton, Diane, primary, Gill, Kathryn, primary, Gray, Christopher H., primary, Konczal, Jennifer, primary, Mezna, Mokdad, primary, McArthur, Duncan, primary, Schüttelkopf, Alexander W., primary, McConnell, Patricia, primary, Sime, Mairi, primary, Holmes, William M., primary, Bower, Justin, primary, McKinnon, Heather J., primary, Drysdale, Martin, primary, Olson, Michael F., primary, and Chalmers, Anthony J., primary

Published
2023
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31. Supplementary figure legends from A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Author

Birch, Joanna L., primary, Strathdee, Karen, primary, Gilmour, Lesley, primary, Vallatos, Antoine, primary, McDonald, Laura, primary, Kouzeli, Ariadni, primary, Vasan, Richa, primary, Qaisi, Abdulrahman Hussain, primary, Croft, Daniel R., primary, Crighton, Diane, primary, Gill, Kathryn, primary, Gray, Christopher H., primary, Konczal, Jennifer, primary, Mezna, Mokdad, primary, McArthur, Duncan, primary, Schüttelkopf, Alexander W., primary, McConnell, Patricia, primary, Sime, Mairi, primary, Holmes, William M., primary, Bower, Justin, primary, McKinnon, Heather J., primary, Drysdale, Martin, primary, Olson, Michael F., primary, and Chalmers, Anthony J., primary

Published
2023
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32. Supplementary video 1 from A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Author

Birch, Joanna L., primary, Strathdee, Karen, primary, Gilmour, Lesley, primary, Vallatos, Antoine, primary, McDonald, Laura, primary, Kouzeli, Ariadni, primary, Vasan, Richa, primary, Qaisi, Abdulrahman Hussain, primary, Croft, Daniel R., primary, Crighton, Diane, primary, Gill, Kathryn, primary, Gray, Christopher H., primary, Konczal, Jennifer, primary, Mezna, Mokdad, primary, McArthur, Duncan, primary, Schüttelkopf, Alexander W., primary, McConnell, Patricia, primary, Sime, Mairi, primary, Holmes, William M., primary, Bower, Justin, primary, McKinnon, Heather J., primary, Drysdale, Martin, primary, Olson, Michael F., primary, and Chalmers, Anthony J., primary

Published
2023
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33. Supplementary video 5 from A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Author

Birch, Joanna L., primary, Strathdee, Karen, primary, Gilmour, Lesley, primary, Vallatos, Antoine, primary, McDonald, Laura, primary, Kouzeli, Ariadni, primary, Vasan, Richa, primary, Qaisi, Abdulrahman Hussain, primary, Croft, Daniel R., primary, Crighton, Diane, primary, Gill, Kathryn, primary, Gray, Christopher H., primary, Konczal, Jennifer, primary, Mezna, Mokdad, primary, McArthur, Duncan, primary, Schüttelkopf, Alexander W., primary, McConnell, Patricia, primary, Sime, Mairi, primary, Holmes, William M., primary, Bower, Justin, primary, McKinnon, Heather J., primary, Drysdale, Martin, primary, Olson, Michael F., primary, and Chalmers, Anthony J., primary

Published
2023
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34. Figure S1 from A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Author

Birch, Joanna L., primary, Strathdee, Karen, primary, Gilmour, Lesley, primary, Vallatos, Antoine, primary, McDonald, Laura, primary, Kouzeli, Ariadni, primary, Vasan, Richa, primary, Qaisi, Abdulrahman Hussain, primary, Croft, Daniel R., primary, Crighton, Diane, primary, Gill, Kathryn, primary, Gray, Christopher H., primary, Konczal, Jennifer, primary, Mezna, Mokdad, primary, McArthur, Duncan, primary, Schüttelkopf, Alexander W., primary, McConnell, Patricia, primary, Sime, Mairi, primary, Holmes, William M., primary, Bower, Justin, primary, McKinnon, Heather J., primary, Drysdale, Martin, primary, Olson, Michael F., primary, and Chalmers, Anthony J., primary

Published
2023
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35. Supplementary Table 1 from A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Author

Birch, Joanna L., primary, Strathdee, Karen, primary, Gilmour, Lesley, primary, Vallatos, Antoine, primary, McDonald, Laura, primary, Kouzeli, Ariadni, primary, Vasan, Richa, primary, Qaisi, Abdulrahman Hussain, primary, Croft, Daniel R., primary, Crighton, Diane, primary, Gill, Kathryn, primary, Gray, Christopher H., primary, Konczal, Jennifer, primary, Mezna, Mokdad, primary, McArthur, Duncan, primary, Schüttelkopf, Alexander W., primary, McConnell, Patricia, primary, Sime, Mairi, primary, Holmes, William M., primary, Bower, Justin, primary, McKinnon, Heather J., primary, Drysdale, Martin, primary, Olson, Michael F., primary, and Chalmers, Anthony J., primary

Published
2023
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36. Supplementary Data 1 from RUNX1 Is a Driver of Renal Cell Carcinoma Correlating with Clinical Outcome

Author

Rooney, Nicholas, primary, Mason, Susan M., primary, McDonald, Laura, primary, Däbritz, J. Henry M., primary, Campbell, Kirsteen J., primary, Hedley, Ann, primary, Howard, Steven, primary, Athineos, Dimitris, primary, Nixon, Colin, primary, Clark, William, primary, Leach, Joshua D.G., primary, Sansom, Owen J., primary, Edwards, Joanne, primary, Cameron, Ewan R., primary, and Blyth, Karen, primary

Published
2023
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37. Supplementary Table 1 from RUNX1 Is a Driver of Renal Cell Carcinoma Correlating with Clinical Outcome

Author

Rooney, Nicholas, primary, Mason, Susan M., primary, McDonald, Laura, primary, Däbritz, J. Henry M., primary, Campbell, Kirsteen J., primary, Hedley, Ann, primary, Howard, Steven, primary, Athineos, Dimitris, primary, Nixon, Colin, primary, Clark, William, primary, Leach, Joshua D.G., primary, Sansom, Owen J., primary, Edwards, Joanne, primary, Cameron, Ewan R., primary, and Blyth, Karen, primary

Published
2023
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38. Supplementary video 2 from A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Author

Birch, Joanna L., primary, Strathdee, Karen, primary, Gilmour, Lesley, primary, Vallatos, Antoine, primary, McDonald, Laura, primary, Kouzeli, Ariadni, primary, Vasan, Richa, primary, Qaisi, Abdulrahman Hussain, primary, Croft, Daniel R., primary, Crighton, Diane, primary, Gill, Kathryn, primary, Gray, Christopher H., primary, Konczal, Jennifer, primary, Mezna, Mokdad, primary, McArthur, Duncan, primary, Schüttelkopf, Alexander W., primary, McConnell, Patricia, primary, Sime, Mairi, primary, Holmes, William M., primary, Bower, Justin, primary, McKinnon, Heather J., primary, Drysdale, Martin, primary, Olson, Michael F., primary, and Chalmers, Anthony J., primary

Published
2023
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39. Supplementary table 2 from A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Author

Birch, Joanna L., primary, Strathdee, Karen, primary, Gilmour, Lesley, primary, Vallatos, Antoine, primary, McDonald, Laura, primary, Kouzeli, Ariadni, primary, Vasan, Richa, primary, Qaisi, Abdulrahman Hussain, primary, Croft, Daniel R., primary, Crighton, Diane, primary, Gill, Kathryn, primary, Gray, Christopher H., primary, Konczal, Jennifer, primary, Mezna, Mokdad, primary, McArthur, Duncan, primary, Schüttelkopf, Alexander W., primary, McConnell, Patricia, primary, Sime, Mairi, primary, Holmes, William M., primary, Bower, Justin, primary, McKinnon, Heather J., primary, Drysdale, Martin, primary, Olson, Michael F., primary, and Chalmers, Anthony J., primary

Published
2023
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40. Supplementary video 6 from A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Author

Birch, Joanna L., primary, Strathdee, Karen, primary, Gilmour, Lesley, primary, Vallatos, Antoine, primary, McDonald, Laura, primary, Kouzeli, Ariadni, primary, Vasan, Richa, primary, Qaisi, Abdulrahman Hussain, primary, Croft, Daniel R., primary, Crighton, Diane, primary, Gill, Kathryn, primary, Gray, Christopher H., primary, Konczal, Jennifer, primary, Mezna, Mokdad, primary, McArthur, Duncan, primary, Schüttelkopf, Alexander W., primary, McConnell, Patricia, primary, Sime, Mairi, primary, Holmes, William M., primary, Bower, Justin, primary, McKinnon, Heather J., primary, Drysdale, Martin, primary, Olson, Michael F., primary, and Chalmers, Anthony J., primary

Published
2023
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41. 'It takes a village', but the village is gone: women's perinatal experiences during COVID-19

Author

Nixon, Kendra (Social Work), Thiessen, Kellie (Nursing)), Bone, Tracey, McDonald, Laura, Nixon, Kendra (Social Work), Thiessen, Kellie (Nursing)), Bone, Tracey, and McDonald, Laura

Abstract

This qualitative study explored women’s perinatal experiences during the COVID-19 pandemic. Specifically, this study sought to not only explore this experience, but to understand if and how their mental health was impacted. Utilizing a feminist theoretical framework, eight women in Winnipeg, Manitoba were interviewed for this study. From these in-depth interviews with women, four main themes were identified: the pandemic’s adverse impact on mental health, experiences of motherhood, challenges to support networks, and silver linings.

Published
2023

42. Real-World Effectiveness, Safety, and Health-Related Quality of Life in Patients Receiving Adjuvant Nivolumab for Melanoma in Belgium and Luxembourg: Results of PRESERV MEL †

Author

Rogiers, Anne, Willemot, Laurence, McDonald, Laura, Van Campenhout, Hilde, Berchem, Guy, Jacobs, Celine, Blockx, Nathalie, Rorive, Andrée, Neyns, Bart, Rogiers, Anne, Willemot, Laurence, McDonald, Laura, Van Campenhout, Hilde, Berchem, Guy, Jacobs, Celine, Blockx, Nathalie, Rorive, Andrée, and Neyns, Bart

Abstract

Background: Nivolumab, an anti–programmed cell death 1 immuno-oncology therapy, is approved as an adjuvant treatment for patients with completely resected stage III or stage IV melanoma. PRESERV MEL (Prospective and REtrospective Study of nivolumab thERapy in adjuVant MELanoma) is a real-world observational study evaluating the effectiveness and safety of adjuvant nivolumab in patients with completely resected stage III or stage IV melanoma in clinical practice in Belgium and Luxembourg. Methods: Patients were enrolled prospectively and retrospectively during a 2-year period (January 2019–January 2021), and will be followed for 5 years. The results reported here are for the second interim analysis (cutoff date 31 December 2021). The index date was the date of first administration of adjuvant nivolumab. Patients received nivolumab for up to 12 months per label. Outcomes included relapse-free survival (RFS), adverse events (AEs)/treatment-related AEs (TRAEs), and health-related quality of life (HRQoL; assessed in prospectively enrolled patients using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30), Functional Assessment of Cancer Therapy—Melanoma (FACT-M), and EQ-5D-3L instruments). HRQoL was evaluated at group level (mean change in scores from baseline based on minimally important differences) and individual patient level (percentage of patients with clinically important scores based on threshold of clinical importance). Outcomes were analyzed descriptively. Results: The study enrolled 152 patients (125 prospective, 27 retrospective) at 15 hospitals in Belgium and Luxembourg. Minimum potential follow-up at time of analysis was 11.4 months. Median age was 60 years (range 29–85), and 53% of patients were male. At 12 and 18 months, the RFS rates were 74.7% (95% confidence interval (CI): 66.9–80.9) and 68.4% (95% CI: 60.0–75.5), respectively. Median RFS was not reached. Grade 3 or 4 TRAEs were reported in 1, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

44. Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging

Author

Floerchinger, Alessia, primary, Murphy, Kendelle J, primary, Latham, Sharissa L., primary, C.Warren, Sean, primary, McCulloch, Andrew T, primary, Kyung Lee, Young, primary, Stoehr, Janett, primary, Mélénec, Pauline, primary, S.Guaman, Cris, primary, Metcalf, Xanthe L, primary, Lee, Victoria, primary, Zaratzian, Anaiis, primary, Da Silva, Andrew, primary, Tayao, Michael, primary, Rolo, Sonia, primary, Phimmachanh, Monica, primary, Sultani, Ghazal, primary, McDonald, Laura, primary, M. Mason, Susan, primary, Ferrari, Nicola, primary, M. Ooms, Lisa, primary, Johnsson, Anna-Karin E, primary, Spence, Heather J, primary, Olson, Michael, primary, Machesky, Laura M., primary, Sansom, Owen J, primary, P. Morton, Jennifer, primary, Mitchell, Christina A., primary, S. Samuel, Michael, primary, Croucher, David R., primary, Welch, Heidi C. E., primary, Blyth, Karen, primary, Caldon, C. Elizabeth, primary, Herrmann, David, primary, I Anderson, Kurt, primary, Timpson, Paul, primary, and Nobis, Max, primary

Published
2023
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45. Comparing treatment and outcomes in advanced esophageal, gastroesophageal junction, and gastric adenocarcinomas: a population-based study

Author

Pape, Marieke, primary, Vissers, Pauline A. J., additional, Dijksterhuis, Willemieke P. M., additional, Bertwistle, David, additional, McDonald, Laura, additional, Mostert, Bianca, additional, Derks, Sarah, additional, Oving, Irma M., additional, Verhoeven, Rob H. A., additional, and van Laarhoven, Hanneke W. M., additional

Published
2023
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46. Bundle Up: CMS Releases Request for Applications for New Version of Bundled Payments for Care Improvement Model

Author

Kanner, Sheree, Roberts, Beth, McDonald, Laura, Choe, Ken, and Furlow, Andrew S.

Subjects
United States. Centers for Medicare and Medicaid Services -- Planning -- Services, Medicare -- Analysis -- Models, Company business planning, Health care industry
Abstract

The Centers for Medicare & Medicaid Services (CMS) recently released details on the muchanticipated new version of the Bundled Payments for Care Improvement (BPCI) payment model, which will be known [...]

Published
2018

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