Author: "McCullen, P." - Searchworks@Jio Institute Digital Library Search Results

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1. Optimising peak energy reduction in networks of buildings

Author: Poghosyan, A., McCullen, N., and Natarajan, S.
Published: 2024
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2. The effect of thermal cycling on the thermal and chemical stability of paraffin phase change materials (PCMs) composites

Author: Wadee, Ahmad, Walker, Pete, McCullen, Nick, and Ferrandiz-Mas, Veronica
Published: 2025
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3. A Review of Additive Manufacturing in Tissue Engineering and Regenerative Medicine

Author: Culbreath, Clayton J., Taylor, M. Scott, McCullen, Seth D., and Mefford, O. Thompson
Published: 2024
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4. Information Gain as a Tool for Assessing Biosignature Missions

Author: Fields, Benjamin, Gupta, Sohom, and Sandora, McCullen
Subjects: Astrophysics - Earth and Planetary Astrophysics, Physics - Data Analysis, Statistics and Probability
Abstract: We propose the mathematical notion of information gain as a way of quantitatively assessing the value of biosignature missions. This makes it simple to determine how mission value depends on design parameters, prior knowledge, and input assumptions. We demonstrate the utility of this framework by applying it to a plethora of case examples: the minimal number of samples needed to determine a trend in the occurrence rate of a signal as a function of an environmental variable, and how much cost should be allocated to each class of object; the relative impact of false positives and false negatives, with applications to Enceladus data and how best to combine two signals; the optimum tradeoff between resolution and coverage in the search for lurkers or other spatially restricted signals, with application to our current state of knowledge for solar system bodies; the best way to deduce a habitability boundary; the optimal amount of money to spend on different mission aspects; when to include an additional instrument on a mission; the optimal mission lifetime; and when to follow/challenge the predictions of a habitability model. In each case, we generate concrete, quantitative recommendations for optimising mission design, mission selection, and/or target selection., Comment: 16 pages, 8 figures
Published: 2023
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5. Multiverse Predictions for Habitability: Origin of Life Scenarios

Author: Sandora, McCullen, Airapetian, Vladimir, Barnes, Luke, Lewis, Geraint F., and Pérez-Rodríguez, Ileana
Subjects: Quantitative Biology - Populations and Evolution, Astrophysics - Earth and Planetary Astrophysics, Physics - Biological Physics
Abstract: If the origin of life is rare and sensitive to the local conditions at the site of its emergence, then, using the principle of mediocrity within a multiverse framework, we may expect to find ourselves in a universe that is better than usual at creating these necessary conditions. We use this reasoning to investigate several origin of life scenarios to determine whether they are compatible with the multiverse, including the prebiotic soup scenario, hydrothermal vents, delivery of prebiotic material from impacts, and panspermia. We find that most of these scenarios induce a preference toward weaker-gravity universes, and that panspermia and scenarios involving solar radiation or large impacts as a disequilibrium source are disfavored. Additionally, we show that several hypothesized habitability criteria which are disfavored when the origin of life is not taken into account become compatible with the multiverse, and that the emergence of life and emergence of intelligence cannot both be sensitive to disequilibrium production conditions., Comment: 27 pages, 4 figures
Published: 2023
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6. Multiverse Predictions for Habitability: Stellar and Atmospheric Habitability

Author: Sandora, McCullen, Airapetian, Vladimir, Barnes, Luke, and Lewis, Geraint F.
Subjects: Astrophysics - Earth and Planetary Astrophysics, Physics - Atmospheric and Oceanic Physics
Abstract: Stellar activity and planetary atmospheric properties have the potential to strongly influence habitability. To date, neither have been adequately studied in the multiverse context, so there has been no assessment of how these effects impact the probabilities of observing our fundamental constants. Here, we consider the effects of solar wind, mass loss, and extreme ultra-violet (XUV) flux on planetary atmospheres, how these effects scale with fundamental constants, and how this affects the likelihood of our observations. We determine the minimum atmospheric mass that can withstand erosion, maintain liquid surface water, and buffer diurnal temperature changes. We consider two plausible sources of Earth's atmosphere, as well as the notion that only initially slowly rotating stars are habitable, and find that all are equally compatible with the multiverse. We consider whether planetary magnetic fields are necessary for habitability, and find five boundaries in parameter space where magnetic fields are precluded. We find that if an Earth-like carbon-to-oxygen ratio is required for life, atmospheric effects do not have much of an impact on multiverse calculations. If significantly different carbon-to-oxygen ratios are compatible with life, magnetic fields must not be essential for life, and planet atmosphere must not scale with stellar nitrogen abundance, or else the multiverse would be ruled out to a high degree of confidence., Comment: 23 pages, 2 figures
Published: 2023
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7. Multiverse Predictions for Habitability: Planetary Characteristics

Author: Sandora, McCullen, Airapetian, Vladimir, Barnes, Luke, and Lewis, Geraint F.
Subjects: Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Recent detections of potentially habitable exoplanets around sunlike stars demand increased exploration of the physical conditions that can sustain life, by whatever methods available. Insight into these conditions can be gained by considering the multiverse hypothesis; in a multiverse setting, the probability of living in our universe depends on assumptions made about the factors affecting habitability. Various proposed habitability criteria can be systematically considered to rate each on the basis of their compatibility with the multiverse, generating predictions which can both guide expectations for life's occurrence and test the multiverse hypothesis. Here, we evaluate several aspects of planetary habitability, and show that the multiverse does indeed induce strong preferences among them. We find that the notion that a large moon is necessary for habitability is untenable in the multiverse scenario, as in the majority of parameter space, moons are not necessary to maintain stable obliquity. Further, we consider various proposed mechanisms for water delivery to the early Earth, including delivery from asteroids, both during giant planet formation and a grand tack, delivery from comets, and oxidation of a primary atmosphere by a magma ocean. We find that, depending on assumptions for how habitability depends on water content, some of these proposed mechanisms are disfavored in the multiverse scenario by Bayes factors of up to several hundred., Comment: 26 pages, 3 figures
Published: 2023
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8. Multiverse Predictions for Habitability: Element Abundances

Author: Sandora, McCullen, Airapetian, Vladimir, Barnes, Luke, Lewis, Geraint F., and Pérez-Rodríguez, Ileana
Subjects: Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract: We investigate the dependence of elemental abundances on physical constants, and the implications this has for the distribution of complex life for various proposed habitability criteria. We consider three main sources of abundance variation: differing supernova rates, alpha burning in massive stars, and isotopic stability, and how each affects the metal-to-rock ratio and the abundances of carbon, oxygen, nitrogen, phosphorus, sulfur, silicon, magnesium, and iron. Our analysis leads to several predictions for which habitability criteria are correct by determining which ones make our observations of the physical constants, as well as a few other observed features of our universe, most likely. Our results indicate that carbon-rich or carbon-poor planets are uninhabitable, slightly magnesium-rich planets are habitable, and life does not depend on nitrogen abundance too sensitively. We also find suggestive but inconclusive evidence that metal-rich planets and phosphorus-poor planets are habitable. These predictions can then be checked by probing regions of our universe that closely resemble normal environments in other universes. If any of these predictions are found to be wrong, the multiverse scenario would predict that the majority of observers are born in universes differing substantially from ours, and so can be ruled out, to varying degrees of statistical significance., Comment: 27 pages, 5 figures
Published: 2023
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9. Emotion regulation profiles and mental health outcomes in American Indian adults

Author: McCullen, Jennifer R., Counts, Cory J., Oosterhoff, Benjamin, and John-Henderson, Neha A.
Published: 2024
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10. Community Report from the Biosignatures Standards of Evidence Workshop

Author: Meadows, Victoria, Graham, Heather, Abrahamsson, Victor, Adam, Zach, Amador-French, Elena, Arney, Giada, Barge, Laurie, Barlow, Erica, Berea, Anamaria, Bose, Maitrayee, Bower, Dina, Chan, Marjorie, Cleaves, Jim, Corpolongo, Andrea, Currie, Miles, Domagal-Goldman, Shawn, Dong, Chuanfei, Eigenbrode, Jennifer, Enright, Allison, Fauchez, Thomas J., Fisk, Martin, Fricke, Matthew, Fujii, Yuka, Gangidine, Andrew, Gezer, Eftal, Glavin, Daniel, Grenfell, Lee, Harman, Sonny, Hatzenpichler, Roland, Hausrath, Libby, Henderson, Bryana, Johnson, Sarah Stewart, Jones, Andrea, Hamilton, Trinity, Hickman-Lewis, Keyron, Jahnke, Linda, Kacar, Betul, Kopparapu, Ravi, Kempes, Christopher, Kish, Adrienne, Krissansen-Totton, Joshua, Leavitt, Wil, Komatsu, Yu, Lichtenberg, Tim, Lindsay, Melody, Maggiori, Catherine, Marais, David Des, Mathis, Cole, Morono, Yuki, Neveu, Marc, Ni, Grace, Nixon, Conor, Olson, Stephanie, Parenteau, Niki, Perl, Scott, Quinn, Richard, Raj, Chinmayee, Rodriguez, Laura, Rutter, Lindsay, Sandora, McCullen, Schmidt, Britney, Schwieterman, Eddie, Segura, Antigona, Sekerci, Fatih, Seyler, Lauren, Smith, Harrison, Soares, Georgia, Som, Sanjoy, Suzuki, Shino, Teece, Bonnie, Weber, Jessica, Wolfe-Simon, Felisa, Wong, Michael, Yano, Hajime, and Young, Liza
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Quantitative Biology - Populations and Evolution
Abstract: The search for life beyond the Earth is the overarching goal of the NASA Astrobiology Program, and it underpins the science of missions that explore the environments of Solar System planets and exoplanets. However, the detection of extraterrestrial life, in our Solar System and beyond, is sufficiently challenging that it is likely that multiple measurements and approaches, spanning disciplines and missions, will be needed to make a convincing claim. Life detection will therefore not be an instantaneous process, and it is unlikely to be unambiguous-yet it is a high-stakes scientific achievement that will garner an enormous amount of public interest. Current and upcoming research efforts and missions aimed at detecting past and extant life could be supported by a consensus framework to plan for, assess and discuss life detection claims (c.f. Green et al., 2021). Such a framework could help increase the robustness of biosignature detection and interpretation, and improve communication with the scientific community and the public. In response to this need, and the call to the community to develop a confidence scale for standards of evidence for biosignature detection (Green et al., 2021), a community-organized workshop was held on July 19-22, 2021. The meeting was designed in a fully virtual (flipped) format. Preparatory materials including readings, instructional videos and activities were made available prior to the workshop, allowing the workshop schedule to be fully dedicated to active community discussion and prompted writing sessions. To maximize global interaction, the discussion components of the workshop were held during business hours in three different time zones, Asia/Pacific, European and US, with daily information hand-off between group organizers., Comment: 86 pages, 14 figures, workshop report
Published: 2022

11. Explaining the Effectiveness of Multi-Task Learning for Efficient Knowledge Extraction from Spine MRI Reports

Author: Sehanobish, Arijit, Sandora, McCullen, Abraham, Nabila, Pawar, Jayashri, Torres, Danielle, Das, Anasuya, Becker, Murray, Herzog, Richard, Odry, Benjamin, and Vianu, Ron
Subjects: Computer Science - Machine Learning, Computer Science - Artificial Intelligence, Computer Science - Computation and Language
Abstract: Pretrained Transformer based models finetuned on domain specific corpora have changed the landscape of NLP. However, training or fine-tuning these models for individual tasks can be time consuming and resource intensive. Thus, a lot of current research is focused on using transformers for multi-task learning (Raffel et al.,2020) and how to group the tasks to help a multi-task model to learn effective representations that can be shared across tasks (Standley et al., 2020; Fifty et al., 2021). In this work, we show that a single multi-tasking model can match the performance of task specific models when the task specific models show similar representations across all of their hidden layers and their gradients are aligned, i.e. their gradients follow the same direction. We hypothesize that the above observations explain the effectiveness of multi-task learning. We validate our observations on our internal radiologist-annotated datasets on the cervical and lumbar spine. Our method is simple and intuitive, and can be used in a wide range of NLP problems., Comment: To appear at NAACL-2022, Industry Track. Follow-up of previous work: arXiv:2204.04544
Published: 2022

12. Biosignature Surveys to Exoplanet Yields and Beyond

Author: Sandora, McCullen and Silk, Joseph
Subjects: Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Quantitative Biology - Other Quantitative Biology
Abstract: Upcoming biosignature searches focus on indirect indicators to infer the presence of life on other worlds. Aside from just signaling the presence of life, however, some biosignatures can contain information about the state that a planet's biosphere has achieved. This additional information can be used to measure what fractions of planets achieve certain key stages, corresponding to the advent of life, photosynthesis, multicellularity, and technological civilization. We forecast the uncertainties of each measurement for upcoming surveys, and outline the key factors that determine these uncertainties. Our approach is probabilistic and relies on large numbers of candidates rather than detailed examination of individual exoplanet spectra. The dependence on survey size, likeliness of the transition, and several measures of degrees of confidence are discussed, including discussion of geological false positives in biosignatures as well as how combining data from different missions can affect the inference. Our analysis should influence policy recommendations for future mission design and strategy to minimize the impact of measurement uncertainties., Comment: 17 pages, 9 figures, accepted to MNRAS
Published: 2020
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13. Symmetries from Locality. II. Gravitation and Lorentz Boosts

Author: Hertzberg, Mark P., Litterer, Jacob A., and Sandora, McCullen
Subjects: High Energy Physics - Theory, Astrophysics - Cosmology and Nongalactic Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology
Abstract: It is known that local, Lorentz invariant, unitary theories involving particles with spin 1 demand that the matter sector they couple to are organized by internal physical symmetries and the associated charge conservation, while spin 3/2 demands supersymmetry. However, the introduction of a spin 2 graviton does not obviously demand new symmetries of the matter sector (although it does demand a universal coupling). In this work we relax the assumption of Lorentz boost symmetry, while maintaining a basic notion of locality that there is no instantaneous signaling at a distance. This extends and complements our accompanying work in Part 1 on related issues for spin 1 particles in electromagnetism. In order to avoid potential problems with longitudinal modes of the graviton, we choose to project them out, leaving only two degrees of freedom. We study large classes of theories that a priori may violate Lorentz boost invariance. By requiring the tree-level exchange action be local, we find that consistency demands that the Lorentz boost symmetry must be satisfied by the graviton and the matter sector, and in turn we recover general relativity at this order of analysis., Comment: 13 pages in double column format. V2 further clarification and fixed some typos. V3: Further clarifications, including mass terms. Updated towards version accepted for publication in Phys. Rev. D, including journal title format
Published: 2020
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14. A joint industry‐sponsored data monitoring committee model for observational, retrospective drug safety studies in the real‐world setting

Author: Major‐Pedersen, Atheline, McCullen, Mary Kate, Sabol, Mary Elizabeth, Adetunji, Omolara, Massaro, Joseph, Neugut, Alfred I, Sosa, Julie Ann, and Hollenberg, Anthony N
Subjects: Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Patient Safety, Prevention, Clinical Trials Data Monitoring Committees, Confidentiality, Humans, Pharmaceutical Preparations, Retrospective Studies, data monitoring committee, joint sponsorship, observational, real&#8208, world data, retrospective, real-world data, Pharmacology and Pharmaceutical Sciences, Public Health and Health Services, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences, Epidemiology
Abstract: PurposeTo share better practice in establishing data monitoring committees (DMCs) for observational, retrospective safety studies with joint-industry sponsorship.MethodsA DMC model was created to monitor data from an observational, retrospective, post-authorization safety study investigating risk of medullary thyroid cancer in patients treated with long-acting glucagon-like peptide-1 receptor agonists (LA GLP-1RAs) (NCT01511393). Sponsors reviewed regulatory guidelines, best practice and sponsors' standard operation procedures on DMCs. Discussions were held within the four-member consortium, assessing applicability to observational, retrospective, real-world studies. A DMC charter was drafted based on a sponsor-proposed, adapted DMC model. Thereafter, a kick-off meeting between sponsors and DMC members was held to receive DMC input and finalize the charter.ResultsDue to this study's observational, retrospective nature, assuring participant safety - central for traditional explanatory clinical trial models - was not applicable to our DMC model. The overall strategy and key indication for our real-world model included preserving study integrity and credibility. Therefore, DMC member independence and their contribution of expert knowledge were essential. To ensure between-sponsor data confidentiality, all study committees/corporations and sponsors, besides the DMC, received blinded data only (adapted to refer to data blinding that revealed the specific marketed LA GLP-1RA/sponsor). Communication and blinding/unblinding of these data were facilitated by the contract research organization, which also provided crucial operational oversight.ConclusionsTo our knowledge, we have established the first DMC model for joint industry-sponsored, observational, retrospective safety studies. This model could serve as a precedent for others performing similar post-marketing, joint industry-sponsored pharmacovigilance activities.
Published: 2021

15. Dark Matter and Naturalness

Author: Hertzberg, Mark P. and Sandora, McCullen
Subjects: High Energy Physics - Phenomenology, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Theory
Abstract: The Standard Model of particle physics is governed by Poincar\'e symmetry, while all other symmetries, exact or approximate, are essentially dictated by theoretical consistency with the particle spectrum. On the other hand, many models of dark matter exist that rely upon the addition of new added global symmetries in order to stabilize the dark matter particle and/or achieve the correct abundance. In this work we begin a systematic exploration into truly natural models of dark matter, organized by only relativity and quantum mechanics, without the appeal to any additional global symmetries, no fine-tuning, and no small parameters. We begin by reviewing how singlet dark sectors based on spin 0 or spin ${1\over2}$ should readily decay, while pure strongly coupled spin 1 models have an overabundance problem. This inevitably leads us to construct chiral models with spin ${1\over2}$ particles charged under confining spin 1 particles. This leads to stable dark matter candidates that are analogs of baryons, with a confinement scale that can be naturally $\mathcal{O}(100)$TeV. This leads to the right freeze-out abundance by annihilating into massless unconfined dark fermions. The minimal model involves a dark copy of $SU(3)\times SU(2)$ with 1 generation of chiral dark quarks and leptons. The presence of massless dark leptons can potentially give rise to a somewhat large value of $\Delta N_{\text{eff}}$ during BBN. In order to not upset BBN one may either appeal to a large number of heavy degrees of freedom beyond the Standard Model, or to assume the dark sector has a lower reheat temperature than the visible sector, which is also natural in this framework. This reasoning provides a robust set of dark matter models that are entirely natural. Some are concrete realizations of the nightmare scenario in which dark matter may be very difficult to detect, which may impact future search techniques., Comment: 32 pages, 3 figures. V2: Further clarifications; updated towards version published in JHEP
Published: 2019
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16. Multiverse Predictions for Habitability: Fraction of Life that Develops Intelligence

Author: Sandora, McCullen
Subjects: Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Do mass extinctions affect the development of intelligence? If so, we may expect to be in a universe that is exceptionally placid. We consider the effects of impacts, supervolcanoes, global glaciations, and nearby gamma ray bursts, and how their rates depend on fundamental constants. It is interesting that despite the very disparate nature of these processes, each occurs on timescales of 100 Myr-Gyr. We argue that this is due to a selection effect that favors both tranquil locales within our universe, as well as tranquil universes. Taking gamma ray bursts to be the sole driver of mass extinctions is disfavored in multiverse scenarios, as the rate is much lower for different values of the fundamental constants. In contrast, geological causes of extinction are very compatible with the multiverse. Various frameworks for the effects of extinctions are investigated, and the intermediate disturbance hypothesis is found to be most compatible with the multiverse., Comment: 30 pages, 6 figures, v2: volcanoes section fixed, matches published version
Published: 2019
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17. Multiverse Predictions for Habitability: Fraction of Planets that Develop Life

Author: Sandora, McCullen
Subjects: Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: In a multiverse context, determining the probability of being in our particular universe depends on estimating its overall habitability compared to other universes with different values of the fundamental constants. One of the most important factors in determining this is the fraction of planets that actually develop life, and how this depends on planetary conditions. Many proposed possibilities for this are incompatible with the multiverse: if the emergence of life depends on the lifetime of its host star, the size of the habitable planet, or the amount of material processed, the chances of being in our universe would be very low. If the emergence of life depends on the entropy absorbed by the planet, however, our position in this universe is very natural. Several proposed models for the subsequent development of life, including the hard step model and several planetary oxygenation models, are also shown to be incompatible with the multiverse. If any of these are observed to play a large role in determining the distribution of life throughout our universe, the~multiverse hypothesis will be ruled out to high significance., Comment: 29 pages, 6 figures, v2: matches published vresion
Published: 2019
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18. Multiverse Predictions for Habitability: Number of Potentially Habitable Planets

Author: Sandora, McCullen
Subjects: Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: How good is our universe at making habitable planets? The answer to this depends on which factors are important for life: Does a planet need to be Earth mass? Does it need to be inside the temperate zone? are systems with hot Jupiters habitable? Here, we adopt different stances on the importance of each of these criteria to determine their effects on the probabilities of measuring the observed values of several physical constants. We find that the presence of planets is a generic feature throughout the multiverse, and for the most part conditioning on their particular properties does not alter our conclusions much. We find conflict with multiverse expectations if planetary size is important and it is found to be uncorrelated with stellar mass, or the mass distribution is too steep. The existence of a temperate circumstellar zone places tight lower bounds on the fine structure constant and electron to proton mass ratio., Comment: 34 pages, 5 figures and 5 tables, v2: matches published version
Published: 2019
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19. Practice before Theory? An Approach for Testing Sequencing Effects in Pedagogical Design

Author: Natarajan, Sukumar, McCullen, Nick, Lo, Steve, Coley, David, Arja, Omaimah Ali, and Moran, Francis
Abstract: Engineering is a practical discipline, dedicated to the solution of problems through the sound application of principles derived from the natural sciences and mathematics. Engineering pedagogy has therefore to balance the need for learners to gain a deep understanding of the theoretical basis of the problem domain whilst grasping its practical implications. However, little is known as to the most effective "sequence of delivery": is it better to begin with theory and build up to practice or vice versa? Here, we present the idea of testing this through a carefully designed pedagogical experiment. We begin by discussing the issues around the creation of a pedagogical experiment to answer such a question, and define the nature and scope of such experiments. We then create a formal framework within which such questions can be tested and present an experiment in the domain of architectural engineering that pilots this new approach. Finally, we discuss the utility of using such a framework to lead evidence-based discussions of pedagogical practice within the engineering education literature, and conclude that similar experiments could be, and should be, completed by other teams wanting to examine delivery order or other binary choice situations.
Published: 2021
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20. Forecasting seasonal to sub-seasonal rainfall in Great Britain using convolutional-neural networks

Author: Barnes, Andrew Paul, McCullen, Nick, and Kjeldsen, Thomas Rodding
Published: 2023
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21. Multiverse Predictions for Habitability: The Number of Stars and their Properties

Author: Sandora, McCullen
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract: In a multiverse setting, we expect to be situated in a universe that is exceptionally good at producing life. Though the conditions for what life needs to arise and thrive are currently unknown, many will be tested in the coming decades. Here we investigate several different habitability criteria, and their influence on multiverse expectations: Does complex life need photosynthesis? Is there a minimum timescale necessary for development? Can life arise on tidally locked planets? Are convective stars habitable? Variously adopting different stances on each of these criteria can alter whether our observed values of the fine structure constant, the electron to proton mass ratio, and the strength of gravity are typical to high significance. This serves as a way of generating predictions for the requirements of life that can be tested with future observations, any of which could falsify the multiverse scenario., Comment: 26 pages, 8 figures, v2: matches published version
Published: 2019
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22. Quantum Fine-Tuning in Stringy Quintessence Models

Author: Hertzberg, Mark P., Sandora, McCullen, and Trodden, Mark
Subjects: High Energy Physics - Theory, Astrophysics - Cosmology and Nongalactic Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology
Abstract: We investigate the extent to which quintessence models for dark energy are fine-tuned in the context of recent swampland conjectures. In particular, the issue is whether there is a double fine-tuning in which both $V$ and $|\nabla V|$ are fine-tuned, or whether there is only a single fine-tuning due to the relation $|\nabla V|\sim V/M_{pl}$ arising naturally. We find that indeed this relation arises naturally in simple string compactifications for some scalars, such as the dilaton and volume modulus, when treated classically. However, we find that quantum effects can spoil this natural relation, unless the scalar is conformally coupled to the matter sector. Furthermore, it is well known that such conformal couplings are generically ruled out by fifth force tests. To avoid these fifth forces, an interesting proposal is to assume the scalar (quintessence) only couples to the hidden sector. However, we then find quantum corrections to $V$ from visible sector Standard Model particles generically spoil the relation. A possible way out of all these problems is to have the scalar conformally coupled to a dark sector that is an exact copy of the Standard Model. This ensures the relation $|\nabla V|\sim V/M_{pl}$ is maintained naturally even when matter particles run in the loop. However, we find that quantum corrections from quintessons or gravitons in the loop spoil the relation if the effective theory has a cutoff greater than $\sim 0.1$ GeV., Comment: 19 pages, 4 figures. V2: Updated references and minor changes. V3: Updated towards version published in PLB
Published: 2018
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23. Charged Planckian Interacting Dark Matter

Author: Garny, Mathias, Palessandro, Andrea, Sandora, McCullen, and Sloth, Martin S.
Subjects: High Energy Physics - Phenomenology, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Theory
Abstract: A minimal model of Cold Dark Matter (CDM) is a very massive particle with only gravitational interactions, also called Planckian Interacting Dark Matter (PIDM). Here we consider an extension of the PIDM framework by an unbroken $U(1)$ gauge symmetry under which the PIDM is charged, but remains only gravitationally coupled to the Standard Model (SM). Contrary to "hidden charged dark matter", the charged PIDM never reaches thermal equilibrium with the SM. The dark sector is populated by freeze-in via gravitational interactions at reheating. If the dark fine-structure constant $\alpha_D$ is larger than about $10^{-3}$, the dark sector thermalizes within itself, and the PIDM abundance is further modified by freeze-out in the dark sector. Interestingly, this largely reduces the dependence of the final abundance on the reheating temperature, as compared to an uncharged PIDM. Thermalization within the dark sector is driven by inelastic radiative processes, and affected by the Landau-Pomeranchuk-Migdal (LPM) effect. The observed CDM abundance can be obtained over a wide mass range from the weak to the GUT scale, and for phenomenologically interesting couplings $\alpha_D\sim 10^{-2}$. Due to the different thermal history, the charged PIDM can be discriminated from "hidden charged dark matter" by more precise measurements of the effective number of neutrino species $N_{\rm eff}$., Comment: 38 pages, 8 figures
Published: 2018
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24. Long-term Outcomes of Persistent Postoperative Opioid Use: A Retrospective Cohort Study.

Author: Aalberg, Jeffrey J., Kimball, Marc D., McIntire, Timothy R., and McCullen, Geoffrey M.
Abstract: Objective: To determine the association between PPOU and the long-term risk of OUD and opioid overdose. Summary Background Data: PPOU is a commonly used outcome in the surgical literature; its incidence and risk factors have been well described. However, its association to long term outcomes, including OUD and opioid overdose, is unknown. Methods: A retrospective cohort study utilizing the Veterans Health Administration corporate data warehouse. Patients undergoing any surgery between January 1, 2008 and December 31, 2018 were included and followed until December 31, 2020. Univariate and multivariate survival analysis were used to determine the association between PPOU and OUD and overdose. Sensitivity analyses were conducted to determine the impact of different definitions of persistent opioid use and the effect of preoperative opioid use. Results: A total of 344,745 patients undergoing surgery were included and followed for a median of 6.18 years (IQR 3.53–9.12). PPOU was associated with an increased hazard of developing both OUD (HR = 1.88, CI: 1.81–1.95, P < 0.001) and overdose (HR = 1.83, CI: 1.72–1.94, P < 0.001). This association remained consistent after adjustment for comorbidities and across all sensitivity analyses. Conclusions: Surgical patients who develop PPOU are at increased risk of both OUD and overdose as compared to surgical patients who do not develop persistent use. [ABSTRACT FROM AUTHOR]
Published: 2025
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25. Theory and Phenomenology of Planckian Interacting Massive Particles as Dark Matter

Author: Garny, Mathias, Palessandro, Andrea, Sandora, McCullen, and Sloth, Martin S.
Subjects: High Energy Physics - Phenomenology, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Theory
Abstract: Planckian Interacting Dark Matter (PIDM) is a minimal scenario of dark matter assuming only gravitational interactions with the standard model and with only one free parameter, the PIDM mass. PIDM can be successfully produced by gravitational scattering in the thermal plasma of the Standard Model sector after inflation in the PIDM mass range from TeV up to the GUT scale, if the reheating temperature is sufficiently high. The minimal assumption of a GUT scale PIDM mass can be tested in the future by measurements of the primordial tensor-to-scalar ratio. While large primordial tensor modes would be in tension with the QCD axion as dark matter in a large mass range, it would favour the PIDM as a minimal alternative to WIMPs. Here we generalise the previously studied scalar PIDM scenario to the case of fermion, vector and tensor PIDM scenarios, and show that the phenomenology is nearly identical, independent of the spin of the PIDM. We also consider the specific realisation of the PIDM as the Kaluza Klein excitation of the graviton in orbifold compactifications of string theory, as well as in models of monodromy inflation and in Higgs inflation. Finally we discuss the possibility of indirect detection of PIDM through non-perturbative decay., Comment: 41 pages, 9 figures, V2: typos corrected
Published: 2017
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26. Anthropics of Aluminum-26 Decay and Biological Homochirality

Author: Sandora, McCullen
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Theory, Nuclear Theory
Abstract: Results of recent experiment reinstate feasibility to the hypothesis that biomolecular homochirality originates from beta decay. Coupled with hints that this process occurred extraterrestrially suggests aluminum-26 as the most likely source. If true, then its appropriateness is highly dependent on the half-life and energy of this decay. Demanding that this mechanism hold places new constraints on the anthropically allowed range for multiple parameters, including the electron mass, difference between up and down quark masses, the fine structure constant, and the electroweak scale. These new constraints on particle masses are tighter than those previously found. However, one edge of the allowed region is nearly degenerate with an existing bound, which, using what is termed here as `the principle of noncoincident peril', is argued to be a strong indicator that the fine structure constant must be an environmental parameter in the multiverse., Comment: 23 pages, 4 figures
Published: 2017
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27. Is Patience a Virtue? Cosmic Censorship of Infrared Effects in de Sitter

Author: Ferreira, Ricardo Z., Sandora, McCullen, and Sloth, Martin S.
Subjects: High Energy Physics - Theory, Astrophysics - Cosmology and Nongalactic Astrophysics, General Relativity and Quantum Cosmology
Abstract: While the accumulation of long wavelength modes during inflation wreaks havoc on the large scale structure of spacetime, the question of even observability of their presence by any local observer has lead to considerable confusion. Though it is commonly agreed that infrared effects are not visible to a single sub-horizon observer at late times, we argue that the question is less trivial for a \emph{patient observer} who has lived long enough to have a record of the state before the soft mode was created. Though classically there is no obstruction to measuring this effect locally, we give several indications that quantum mechanical uncertainties censor the effect, rendering the observation of long modes ultimately forbidden., Comment: 7 pages, awarded honorable mention in the 2017 Gravity Research Foundation Essays on Gravitation competition
Published: 2017
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28. Special Relativity from Soft Gravitons

Author: Hertzberg, Mark P. and Sandora, McCullen
Subjects: High Energy Physics - Theory, Astrophysics - Cosmology and Nongalactic Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology
Abstract: We study all translationally and rotationally invariant local theories involving massless spin 2 and spin 1 particles that mediate long range forces, allowing for general energy relations and violation of boost invariance. Although gauge invariance is not a priori required to describe non Lorentz invariant theories, we first establish that locality requires `soft gauge invariance'. Then by taking the soft graviton limit in scattering amplitudes, we prove that in addition to the usual requirement of universal graviton couplings, the special relativistic energy-momentum relation is also required and must be exact. We contrast this to the case of theories with only spin $\leq1$ particles, where, although we can still derive charge conservation from locality, special relativity can be easily violated. We provide indications that the entire structure of relativity can be built up from spin 2 in this fashion., Comment: 6 pages in double column format, 1 figure. V2: Added appendix on more details of locality in spin 2; expanded discussion with comments on implications for Lorentz violating models; added references
Published: 2017
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29. Patient Observers and Non-perturbative Infrared Dynamics in Inflation

Author: Ferreira, Ricardo Z., Sandora, McCullen, and Sloth, Martin S.
Subjects: High Energy Physics - Theory, Astrophysics - Cosmology and Nongalactic Astrophysics, General Relativity and Quantum Cosmology
Abstract: We have previously derived the effect of soft graviton modes on the quantum state of de Sitter using spontaneously broken asymptotic symmetries. In the present paper we reinterpret this effect in terms of particle production and relate the quantum states with and without soft modes by means of Bogoliubov transformations. This also enables us to address the much discussed issues regarding the observability of infrared effects in de Sitter from a new perspective. While it is commonly agreed that infrared effects are not visible to a single sub-horizon observer at late times, we argue that the question is less trivial for a {\it patient observer} who has lived long enough to have a record of the state before the soft mode was created. Though classically there is no obstruction to measuring this effect locally, we give several indications that quantum mechanical uncertainties may censor the effect. We then apply our methods to find a non-perturbative description of the quantum state pertaining to the Page time of de Sitter, and derive with these new methods the probability distribution for the local quantum states of de Sitter and slow-roll inflation in the presence of long modes. Finally, we use this to formulate a precise criterion for the existence of eternal inflation in general classes of slow-roll inflation., Comment: 37 pages
Published: 2017
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30. General Relativity from Causality

Author: Hertzberg, Mark P. and Sandora, McCullen
Subjects: High Energy Physics - Theory, Astrophysics - Cosmology and Nongalactic Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology
Abstract: We study large families of theories of interacting spin 2 particles from the point of view of causality. Although it is often stated that there is a unique Lorentz invariant effective theory of massless spin 2, namely general relativity, other theories that utilize higher derivative interactions do in fact exist. These theories are distinct from general relativity, as they permit any number of species of spin 2 particles, are described by a much larger set of parameters, and are not constrained to satisfy the equivalence principle. We consider the leading spin 2 couplings to scalars, fermions, and vectors, and systematically study signal propagation in all these other families of theories. We find that most interactions directly lead to superluminal propagation of either a spin 2 particle or a matter particle, and interactions that are subluminal generate other interactions that are superluminal. Hence, such theories of interacting multiple spin 2 species have superluminality, and by extension, acausality. This is radically different to the special case of general relativity with a single species of minimally coupled spin 2, which leads to subluminal propagation from sources satisfying the null energy condition. This pathology persists even if the spin 2 field is massive. We compare these findings to the analogous case of spin 1 theories, where higher derivative interactions can be causal. This makes the spin 2 case very special, and suggests that multiple species of spin 2 is forbidden, leading us to general relativity as essentially the unique internally consistent effective theory of spin 2., Comment: 31 pages, 4 figures, 1 table. V2: Some clarifications on EFT breakdown and comparison to GR. Updated to resemble version published in JHEP
Published: 2017
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31. Evaluation of Post-Processing on Additive Manufactured Bioresorbable Polymers for Medical Devices.

Author: Culbreath, Clayton J., McCullen, Seth D., and Mefford, O. Thompson
Published: 2024
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32. Asymptotic Symmetries in de Sitter and Inflationary Spacetimes

Author: Ferreira, Ricardo Z., Sandora, McCullen, and Sloth, Martin S.
Subjects: High Energy Physics - Theory, Astrophysics - Cosmology and Nongalactic Astrophysics, General Relativity and Quantum Cosmology
Abstract: Soft gravitons produced by the expansion of de Sitter can be viewed as the Nambu-Goldstone bosons of spontaneously broken asymptotic symmetries of the de Sitter spacetime. We explicitly construct the associated charges, and show that acting with the charges on the vacuum creates a new state equivalent to a change in the local coordinates induced by the soft graviton. While the effect remains unobservable within the domain of a single observer where the symmetry is unbroken, this change is physical when comparing different asymptotic observers, or between a transformed and un-transformed initial state, consistent with the scale-dependent statistical anisotropies previously derived using semiclassical relations. We then compute the overlap, $\langle0| 0'\rangle$, between the unperturbed de Sitter vacuum $|0\rangle$, and the state $| 0'\rangle$ obtained by acting $\mathcal{N}$ times with the charge. We show that when $\mathcal{N}\to M_p^2/H^2$ this overlap receives order one corrections and $\langle0| 0'\rangle\to 0$, which corresponds to an infrared perturbative breakdown after a time $t_{dS} \sim M_p^2/H^3$ has elapsed, consistent with earlier arguments in the literature arguing for a perturbative breakdown on this timescale. We also discuss the generalization to inflation, and rederive the 3-point and one-loop consistency relations., Comment: 22 pages + appendices, 3 figures. V2: Typos fixed, references and clarifications added
Published: 2016
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33. The Fine Structure Constant and Habitable Planets

Author: Sandora, McCullen
Subjects: Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Earth and Planetary Astrophysics, High Energy Physics - Theory
Abstract: We use the existence of habitable planets to impose anthropic requirements on the fine structure constant, $\alpha$. To this effect, we present two considerations that restrict its value to be very near the one observed. The first, that the end product of stellar fusion is iron and not one of its neighboring elements, restricts $\alpha^{-1}$ to be $145\pm 50$. The second, that radiogenic heat in the Earth's interior remains adequately productive for billions of years, restricts it to be $145\pm9$. A connection with the grand unified theory window is discussed, effectively providing a route to probe ultra-high energy physics with upcoming advances in planetary science., Comment: 24 pages, 4 figures
Published: 2016
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34. PETRA: A generalised real-time event detection platform at JET for disruption prediction, avoidance and mitigation

Author: Stuart, C.I., Artaserse, G., Card, P., Carvalho, I.S., Felton, R., Gerasimov, S.N., Goodyear, A., Henriques, R.B., Karkinsky, D., Lomas, P.J., McCullen, P., Rimini, F., Stephen, A.V., Valcárcel, D.F., Waterhouse, J., and Wheatley, M.
Published: 2021
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35. A LIFE OF SERVICE.

Author: McCULLEN, KENYA
Published: 2024

36. Pattern Formation on Networks: from Localised Activity to Turing Patterns

Author: McCullen, Nick and Wagenknecht, Thomas
Subjects: Nonlinear Sciences - Adaptation and Self-Organizing Systems, Mathematical Physics, Mathematics - Dynamical Systems, Nonlinear Sciences - Pattern Formation and Solitons
Abstract: Systems of dynamical interactions between competing species can be used to model many complex systems, and can be mathematically described by {\em random} networks. Understanding how patterns of activity arise in such systems is important for understanding many natural phenomena. The emergence of patterns of activity on complex networks with reaction-diffusion dynamics on the nodes is studied here. The connection between solutions with a single activated node, which can bifurcate from an undifferentiated state, and the fully developed system-scale patterns are investigated computationally. The different coexisting patterns of activity the network can exhibit are shown to be connected via a snaking type bifurcation structure, similar to those responsible for organising localised pattern formation in regular lattices. These results reveal the origin of the multistable patterns found in systems organised on complex networks. A key role is found to be played by nodes with so called {\em optimal degree}, on which the interaction between the reaction kinetics and the network structure organise the behaviour of the system. A statistical representation of the density of solutions over the parameter space is used as a means to answer important questions about the number of accessible states that can be exhibited in systems with such a high degree of complexity.
Published: 2016

37. Planckian Interacting Massive Particles as Dark Matter

Author: Garny, Mathias, Sandora, McCullen, and Sloth, Martin S.
Subjects: High Energy Physics - Phenomenology, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Theory
Abstract: The Standard Model could be self-consistent up to the Planck scale according to the present measurements of the Higgs mass and top quark Yukawa coupling. It is therefore possible that new physics is only coupled to the Standard Model through Planck suppressed higher dimensional operators. In this case the WIMP miracle is a mirage, and instead minimality as dictated by Occam's razor would indicate that dark matter is related to the Planck scale, where quantum gravity is anyway expected to manifest itself. Assuming within this framework that dark matter is a Planckian Interacting Massive Particle, we show that the most natural mass larger than $0.01\,\textrm{M}_p$ is already ruled out by the absence of tensor modes in the CMB. This also indicates that we expect tensor modes in the CMB to be observed soon for this type of minimal dark matter model. Finally, we touch upon the KK graviton mode as a possible realization of this scenario within UV complete models, as well as further potential signatures and peculiar properties of this type of dark matter candidate. This paradigm therefore leads to a subtle connection between quantum gravity, the physics of primordial inflation, and the nature of dark matter., Comment: 6 pages, 1 figure, Version published in PRL
Published: 2015
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38. Spinodal Backreaction During Inflation and Initial Conditions

Author: Richard, Benoit J. and Sandora, McCullen
Subjects: High Energy Physics - Theory, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology
Abstract: We investigate how long wavelength inflationary fluctuations can cause the background field to deviate from classical dynamics. For generic potentials, we show that, in the Hartree approximation, the long wavelength dynamics can be encapsulated by a two-field model operating in an effective potential. The latter is given by a simple Gaussian integral transformation of the original inflationary potential. We use this new expression to study backreaction effects in quadratic, hilltop, flattened, and axion monodromy potentials. We find that the net result of the altered dynamics is to slightly modify the spectral tilt, drastically decrease the tensor-to-scalar ratio, and to effectively smooth over any features of the potential, with the size of these deviations set by the initial value of power in large scale modes and the shape of the potential during the entire evolution., Comment: 30 pages, 8 figures
Published: 2015
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39. Awareness within Local Authorities in England of Autism Spectrum Diagnoses of Looked-After Children

Author: Parsons, Sarah, McCullen, Alice, Emery, Tracey, and Kovshoff, Hanna
Abstract: Educational outcomes for looked-after children on the autism spectrum are significantly poorer than for autistic children not being looked-after by their local authority (those 'in care'), and poorer than for most other groups of children with special educational needs who are looked-after in England. Such poor outcomes have led to calls for specific attention to be paid to the needs of autistic looked-after children within the care of local authorities. There is also evidence that the numbers of autistic children being looked-after by local authorities could be under-represented in official figures. This study sought to find the current numbers of autistic looked-after children formally recorded across local authorities in England, and whether their needs are given special attention via strategic planning and oversight, using freedom of information (FoI) requests sent to all local authorities in England. From the 147 (97%) local authorities who responded, approximately 3% of looked-after children in England are recorded as having an autism spectrum diagnosis, although this is still very likely to be an underestimation. The majority of local authorities do not routinely monitor or report on the diagnostic status of autistic looked-after children at a strategic level. Implications for research and practice are discussed.
Published: 2019
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40. Chapter Two: The multifaceted roles of TCF1 in innate and adaptive lymphocytes.

Author: McCullen, Matthew and Oltz, Eugene
Subjects: INNATE lymphoid cells, KILLER cells, TRANSCRIPTION factors, T cells, REGULATOR genes
Abstract: The immune system requires a complex network of specialized cell types to defend against a range of threats. The specific roles and destinies of these cell types are enforced by a constellation of gene regulatory programs, which are orchestrated through lineage-specifying transcription factors. T Cell Factor 1 (TCF1) is a central transcription factor in many of these programs, guiding the development and functionality of both adaptive and innate lymphoid cells. This review highlights recent insights into the function of TCF1 in a variety of lymphoid cell subsets and its potential for translational applications in immune disorders and cancer. [ABSTRACT FROM AUTHOR]
Published: 2024
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41. Radiative Corrections from Heavy Fast-Roll Fields during Inflation

Author: Jain, Rajeev Kumar, Sandora, McCullen, and Sloth, Martin S.
Subjects: High Energy Physics - Theory, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Phenomenology
Abstract: We investigate radiative corrections to the inflaton potential from heavy fields undergoing a fast-roll phase transition. We find that a logarithmic one-loop correction to the inflaton potential involving this field can induce a temporary running of the spectral index. The induced running can be a short burst of strong running, which may be related to the observed anomalies on large scales in the cosmic microwave spectrum, or extend over many e-folds, sustaining an effectively constant running to be searched for in the future. We implement this in a general class of models, where effects are mediated through a heavy messenger field sitting in its minimum. Interestingly, within the present framework it is a generic outcome that a large running implies a small field model with a vanishing tensor-to-scalar ratio, circumventing the normal expectation that small field models typically lead to an unobservable small running of the spectral index. An observable level of tensor modes can also be accommodated, but, surprisingly, this requires running to be induced by a curvaton. If upcoming observations are consistent with a small tensor-to-scalar ratio as predicted by small field models of inflation, then the present study serves as an explicit example contrary to the general expectation that the running will be unobservable., Comment: 35 pages, 4 figures, matches published version
Published: 2015
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42. A Dynamical Model of Decision-Making Behaviour in a Network of Consumers with Applications to Energy Choices

Author: McCullen, Nick. J., Ivanchenko, Mikhail. V., Shalfeev, Vladimir. D., and Gale, William. F.
Subjects: Nonlinear Sciences - Adaptation and Self-Organizing Systems
Abstract: A consumer Behaviour model is considered in the context of a network of interacting individuals in an energy market. We propose and analyse a simple dynamical model of an ensemble of coupled active elements mimicking consumers' Behaviour, where ``word-of-mouth'' interactions between individuals is important. A single element is modelled using the automatic control system framework. Assuming local (nearest neighbour) coupling we study the evolution of chains and lattices of the model consumers on variation of the coupling strength and initial conditions. The results are interpreted as the dynamics of the decision-making process by the energy-market consumers. We demonstrate that a pitchfork bifurcation to the homogeneous solution leads to bistability of stationary regimes, while the autonomous system is always monostable. In presence of inhomogeneities this results in the formation of clusters of sharply positive and negative opinions. We also find that, depending on the coupling strength, the perturbations caused by inhomogeneities can be exponentially Localised in space or de-Localised. In the latter case the coarse-graining of opinion clusters occurs.
Published: 2014
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43. Spherical Cows in the Sky with Fab Four

Author: Kaloper, Nemanja and Sandora, McCullen
Subjects: High Energy Physics - Theory, Astrophysics - Cosmology and Nongalactic Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology
Abstract: We explore spherically symmetric static solutions in a subclass of unitary scalar-tensor theories of gravity, called the `Fab Four' models. The weak field large distance solutions may be phenomenologically viable, but only if the Gauss-Bonnet term is negligible. Only in this limit will the Vainshtein mechanism work consistently. Further, classical constraints and unitarity bounds constrain the models quite tightly. Nevertheless, in the limits where the range of individual terms at large scales is respectively Kinetic Braiding, Horndeski, and Gauss-Bonnet, the horizon scale effects may occur while the theory satisfies Solar system constraints and, marginally, unitarity bounds. On the other hand, to bring the cutoff down to below a millimeter constrains all the couplings scales such that `Fab Fours' can't be heard outside of the Solar system., Comment: 15 pages, LaTeX
Published: 2013
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44. Topological Ghosts: the Teeming of the Shrews

Author: Kaloper, Nemanja and Sandora, McCullen
Subjects: High Energy Physics - Theory, Astrophysics - Cosmology and Extragalactic Astrophysics, General Relativity and Quantum Cosmology, High Energy Physics - Phenomenology
Abstract: We consider dynamics of spacetime volume-filling form fields with "wrong sign" kinetic terms, such as in so-called Type-II$^*$ string theories. Locally, these form fields are just additive renormalizations of the cosmological constant. They have no fluctuating degrees of freedom. However, once the fields are coupled to membranes charged under them, their configurations are unstable: by a process analogous to Schwinger pair production the field space-filling flux increases. This reduces the cosmological constant, and preserves the null energy condition, since the processes that can violate it by reducing the form flux are very suppressed. The increase of the form flux implies that as time goes on the probability for further membrane nucleation {\it increases}, in contrast to the usual case where the field approaches its vacuum value and ceases to induce further transitions. Thus, in such models spaces with tiny positive vacuum energy are ultimately unstable, but the instability may be slow and localized. In a cosmological setting, this instability can enhance black hole rate formation, by locally making the vacuum energy negative at late times, which constrains the scales controlling membrane dynamics, and may even collapse a large region of the visible universe., Comment: 1+13 pages, 2 figures
Published: 2012
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45. Multi-parameter models of innovation diffusion on complex networks

Author: McCullen, Nicholas J., Rucklidge, Alastair M., Bale, Catherine S. E., Foxon, Tim J., and Gale, William F.
Subjects: Nonlinear Sciences - Adaptation and Self-Organizing Systems, Computer Science - Multiagent Systems, Computer Science - Social and Information Networks, Physics - Physics and Society
Abstract: A model, applicable to a range of innovation diffusion applications with a strong peer to peer component, is developed and studied, along with methods for its investigation and analysis. A particular application is to individual households deciding whether to install an energy efficiency measure in their home. The model represents these individuals as nodes on a network, each with a variable representing their current state of adoption of the innovation. The motivation to adopt is composed of three terms, representing personal preference, an average of each individual's network neighbours' states and a system average, which is a measure of the current social trend. The adoption state of a node changes if a weighted linear combination of these factors exceeds some threshold. Numerical simulations have been carried out, computing the average uptake after a sufficient number of time-steps over many realisations at a range of model parameter values, on various network topologies, including random (Erdos-Renyi), small world (Watts-Strogatz) and (Newman's) highly clustered, community-based networks. An analytical and probabilistic approach has been developed to account for the observed behaviour, which explains the results of the numerical calculations.
Published: 2012
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46. The Origin of Power-Law Emergent Scaling in Large Binary Networks

Author: Almond, D. P., Budd, C. J., Freitag, M. A., Hunt, G. W., McCullen, N. J., and Smith, N. D.
Subjects: Condensed Matter - Disordered Systems and Neural Networks, Condensed Matter - Materials Science, Mathematical Physics, Nonlinear Sciences - Adaptation and Self-Organizing Systems
Abstract: In this paper we study the macroscopic conduction properties of large but finite binary networks with conducting bonds. By taking a combination of a spectral and an averaging based approach we derive asymptotic formulae for the conduction in terms of the component proportions p and the total number of components N. These formulae correctly identify both the percolation limits and also the emergent power law behaviour between the percolation limits and show the interplay between the size of the network and the deviation of the proportion from the critical value of p = 1/2. The results compare excellently with a large number of numerical simulations.
Published: 2012
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47. Creating Competitive Advantage: The Growth of Independent Bookstores in the U.S. 2009–2018

Author: Baidis, Samaher, Greco, Albert N., Kontolios, Michael D., McCullen, Molly, Rittenhouse, Nan, and Wharton, Robert M.
Published: 2019
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48. Alchemy of feelings: Loss, laughter, eros, and new gender subjectivities

Author: McCullen, Christie
Subjects: comedy, pornography, subjectivity, hailing, erotics, affect, emotion, culture, performance, artificial insemination
Abstract: “The lights were low, all the candles on fertility altar lit, the mood—just right. Maddy pulled out all her blowjob tricks—the pepper grinder, the text message, the piccolo tickolo. Leroy was overcum with ecstasy as he spunked into a cup.” So begins the pornographic performance entitledMaddy & Leroy’s Artifuckial Insemination, a kinky tale of a heterosexual couple’s experience with an artificial insemination. It proceeds like this: Leroy spanks and doses Maddy with a hormonal supplement, Maddy orgasms first upon hearing that her insurance pays for the hormones and then several times more after being double-teamed by two female doctors wielding a vibrating, sperm-injecting turkey baster. As the author narrates the story from the side, an exotic dancer playfully strips off a lab coat and bra, flosses between her legs with a stethoscope, and shoots white liquid out of a syringe. And all along everyone laughs because—clearly—none of this is hot…or is it?
Published: 2012

49. Enhanced performance in fusion plasmas through turbulence suppression by megaelectronvolt ions

Author: Mazzi, S., Garcia, J., Zarzoso, D., Kazakov, Y., Ongena, J., Dreval, M., Nocente, M., Stancar, Z., Szepesi, G., Eriksson, J., Sahlberg, A., Benkadda, S., Abid, N., Abraham, K., Abreu, P., Adabonyan, O., Adrich, P., Afanasev, V., Afzal, M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Akhtar, M., Albanese, R., Alderson-Martin, M., Alegre, D., Aleiferis, S., Aleksa, A., Alekseev, A., Alessi, E., Aleynikov, P., Algualcil, J., Ali, M., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V., Andersson Sunden, E., Andrew, P., Angelini, B., Angioni, C., Antoniou, I., Appel, L., Appelbee, C., Aria, S., Ariola, M., Artaserse, G., Arter, W., Artigues, V., Asakura, N., Ash, A., Ashikawa, N., Aslanyan, V., Astrain, M., Asztalos, O., Auld, D., Auriemma, F., Austin, Y., Avotina, L., Aymerich, E., Baciero, A., Bairaktaris, F., Balbin, J., Balbinot, L., Balboa, I., Balden, M., Balshaw, C., Balshaw, N., Bandaru, V., Banks, J., Baranov, Y., Barcellona, C., Barnard, A., Barnard, M., Barnsley, R., Barth, A., Baruzzo, M., Barwell, S., Bassan, M., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P., Beckett, D., Begolli, A., Beidler, M., Bekris, N., Beldishevski, M., Belli, E., Belli, F., Belonohy, E., Ben Yaala, M., Benayas, J., Bentley, J., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Betar, H., Beurskens, M., Bickerton, S., Bieg, B., Bielecki, J., Bierwage, A., Biewer, T., Bilato, R., Bílkova, P., Birkenmeier, G., Bishop, H., Bizarro, J., Blackburn, J., Blanchard, P., Blatchford, P., Bobkov, V., Boboc, A., Bohm, P., Bohm, T., Bolshakova, I., Bolzonella, T., Bonanomi, N., Bonfiglio, D., Bonnin, X., Bonofiglo, P., Boocock, S., Booth, A., Booth, J., Borba, D., Borodin, D., Borodkina, I., Boulbe, C., Bourdelle, C., Bowden, M., Boyd, K., Bozicevic Mihalic, I., Bradnam, S., Braic, V., Brandt, L., Bravanec, R., Breizman, B., Brett, A., Brezinsek, S., Brix, M., Bromley, K., Brown, B., Brunetti, D., Buckingham, R., Buckley, M., Budny, R., Buermans, J., Bufferand, H., Buratti, P., Burgess, A., Buscarino, A., Busse, A., Butcher, D., Cal, E., Calabro, G., Calacci, L., Calado, R., Camenen, Y., Canal, G., Cannas, B., Cappelli, M., Carcangiu, S., Card, P., Cardinali, A., Carman, P., Carnevale, D., Carr, M., Carralero, D., Carraro, L., Carvalho, I., Carvalho, P., Casiraghi, I., Casson, F., Castaldo, C., Catalan, J., Catarino, N., Causa, F., Cavedon, M., Cecconello, M., Challis, C., Chamberlain, B., Chang, C., Chankin, A., Chapman, B., Chernyshova, M., Chiariello, A., Chmielewski, P., Chomiczewska, A., Chone, L., Ciraolo, G., Ciric, D., Citrin, J., Ciupinski, t., Clark, M., Clarkson, R., Clements, C., Cleverly, M., Coad, J., Coates, P., Cobalt, A., Coccorese, V., Coelho, R., Coenen, J., Coffey, I., Colangeli, A., Colas, L., Collins, C., Collins, J., Collins, S., Conka, D., Conroy, S., Conway, B., Conway, N., Coombs, D., Cooper, P., Cooper, S., Corradino, C., Corrigan, G., Coster, D., Cox, P., Craciunescu, T., Cramp, S., Crapper, C., Craven, D., Craven, R., Crialesi Esposito, M., Croci, G., Croft, D., Croitoru, A., Crombe, K., Cronin, T., Cruz, N., Crystal, C., Cseh, G., Cufar, A., Cullen, A., Curuia, M., Czarski, T., Dabirikhah, H., Dal Molin, A., Dale, E., Dalgliesh, P., Dalley, S., Dankowski, J., David, P., Davies, A., Davies, S., Davis, G., Dawson, K., Dawson, S., Day, I., De Bock, M., De Temmerman, G., De Tommasi, G., Deakin, K., Deane, J., Dejarnac, R., Del Sarto, D., Delabie, E., Del-Castillo-Negrete, D., Dempsey, A., Dendy, R., Devynck, P., Di Siena, A., Di Troia, C., Dickson, T., Dinca, P., Dittmar, T., Dobrashian, J., Doerner, R., Donne, A., Dorling, S., Dormido-Canto, S., Douai, D., Dowson, S., Doyle, R., Drewelow, P., Drews, P., Drummond, G., Duckworth, P., Dudding, H., Dumont, R., Dumortier, P., Dunai, D., Dunatov, T., Dunne, M., Duran, I., Durodie, F., Dux, R., Dvornova, A., Eastham, R., Edwards, J., Eich, T., Eichorn, A., Eidietis, N., Eksaeva, A., Haroun, H., Ellwood, G., Elsmore, C., Embreus, O., Emery, S., Ericsson, G., Eriksson, B., Eriksson, F., Eriksson, L., Ertmer, S., Esquembri, S., Esquisabel, A., Estrada, T., Evans, G., Evans, S., Fable, E., Fagan, D., Faitsch, M., Falessi, M., Fanni, A., Farahani, A., Farquhar, I., Fasoli, A., Faugeras, B., Fazinie, S., Felici, F., Felton, R., Fernandes, A., Fernandes, H., Ferrand, J., Ferreira, D., Ferreira, J., Ferro, G., Fessey, J., Ficker, O., Field, A., Figueiredo, A., Figueiredo, J., Fil, A., Fil, N., Finburg, P., Fiorucci, D., Fischer, U., Fishpool, G., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Flinders, K., Foley, S., Fonnesu, N., Fontana, M., Fontdecaba, J., Forbes, S., Formisano, A., Fornal, T., Fortuna, L., Fortuna-Zalesna, E., Fortune, M., Fowler, C., Fransson, E., Frassinetti, L., Freisinger, M., Fresa, R., Fridstrom, R., Frigione, D., Fülop, T., Furseman, M., Fusco, V., Futatani, S., Gadariya, D., Gal, K., Galassi, D., Gafezka, K., Galeani, S., Gallart, D., Galvao, 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ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Swiss Plasma Center (SPC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratory for Plasma Physics (LPP), Ecole Royale Militaire / Koninklijke Militaire School (ERM KMS), Kharkiv Institute of Physics and Technology (Ukraine), V.N. Karazin Kharkiv National University (KhNU), Dipartimento di Fisica (Milano), Università degli Studi di Milano = University of Milan (UNIMI), Consiglio Nazionale delle Ricerche [Milano] (CNR), Jozef Stefan Institute [Ljubljana] (IJS), Culham Centre for Fusion Energy (CCFE), Department of Physics and Astronomy [Uppsala], Uppsala University, This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 and 2019–2020 under Grant agreement No 633053., Mazzi, S, Garcia, J, Zarzoso, D, Kazakov, Y, Ongena, J, Dreval, M, Nocente, M, Stancar, Z, Szepesi, G, Eriksson, J, Sahlberg, A, Benkadda, S, Abid, N, Abraham, K, Abreu, P, Adabonyan, O, Adrich, P, Afzal, M, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Akhtar, M, Albanese, R, Alderson-Martin, M, Alegre, D, Aleiferis, S, Aleksa, A, Alessi, E, Aleynikov, P, Algualcil, J, Ali, M, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, 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K., Zoulias, I., Zwingmann, W., Zychor, I., JET Contributors, Science and Technology of Nuclear Fusion, EIRES Eng. for Sustainable Energy Systems, Magneto-Hydro-Dynamic Stability of Fusion Plasmas, Applied Physics and Science Education, Kazakov, Yo, VTT Technical Research Centre of Finland, Culham Science Centre, Princeton Plasma Physics Laboratory, Department of Applied Physics, European Commission, Forschungszentrum Jülich, Universidade Lisboa, Fusion and Plasma Physics, University of Milan - Bicocca, Aalto University, General Atomics, ITER, University of Toyama, CEA, Oak Ridge National Laboratory, Technical University of Madrid, Swiss Federal Institute of Technology Lausanne, Dutch Institute for Fundamental Energy Research, Royal Military Academy, Seoul National University, Chalmers University of Technology, Max Planck Institute for Plasma Physics, KTH Royal Institute of Technology, and Aalto-yliopisto
Subjects: [PHYS]Physics [physics], Settore FIS/01, Settore ING-IND/18 - Fisica dei Reattori Nucleari, General Physics and Astronomy, simulation, magnetically confined plasma, nuclear fusion, tokamaks, turbulence suppression, Plasma, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], confinement, transport, Alpha particles, Fusion reactors, Turbulence, physics
Abstract: openaire: EC/H2020/633053/EU//EUROfusion Funding Information: We thank M. Baruzzo and F. Nave for the preparation and execution of JET experiments discussed in this paper; E. de la Luna for support in detailing the experimental diagnostics of JET; A. Ho for assistance in processing the experimental data; T. Görler for providing essential advice to ensure the correct numerical setup for the GENE modelling reported in this paper; Y. Camenen, X. Garbet and A. Bierwage for fruitful discussions about the gyrokinetic analyses; G. Giruzzi for valuable suggestions on the article strategy. The simulations were performed on the IRENE Joliot-Curie HPC system, in the framework of the PRACE projects IONFAST and AFIETC, led by J. Garcia, and on the CINECA Marconi HPC within the project GENE4EP, led by D. Zarzoso. This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014-2018 and 2019-2020 under grant agreement no. 633053. The views and opinions express herein do not necessarily reflect those of the European Commission. Part of the work by Ye. O. Kazakov and J.Ongena was also carried out in the framework of projects done for the ITER Scientist Fellow Network (ISFN). Funding Information: We thank M. Baruzzo and F. Nave for the preparation and execution of JET experiments discussed in this paper; E. de la Luna for support in detailing the experimental diagnostics of JET; A. Ho for assistance in processing the experimental data; T. Görler for providing essential advice to ensure the correct numerical setup for the GENE modelling reported in this paper; Y. Camenen, X. Garbet and A. Bierwage for fruitful discussions about the gyrokinetic analyses; G. Giruzzi for valuable suggestions on the article strategy. The simulations were performed on the IRENE Joliot-Curie HPC system, in the framework of the PRACE projects IONFAST and AFIETC, led by J. Garcia, and on the CINECA Marconi HPC within the project GENE4EP, led by D. Zarzoso. This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014-2018 and 2019-2020 under grant agreement no. 633053. The views and opinions express herein do not necessarily reflect those of the European Commission. Part of the work by Ye. O. Kazakov and J.Ongena was also carried out in the framework of projects done for the ITER Scientist Fellow Network (ISFN). Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature Limited. Alpha particles with energies on the order of megaelectronvolts will be the main source of plasma heating in future magnetic confinement fusion reactors. Instead of heating fuel ions, most of the energy of alpha particles is transferred to electrons in the plasma. Furthermore, alpha particles can also excite Alfvénic instabilities, which were previously considered to be detrimental to the performance of the fusion device. Here we report improved thermal ion confinement in the presence of megaelectronvolts ions and strong fast ion-driven Alfvénic instabilities in recent experiments on the Joint European Torus. Detailed transport analysis of these experiments reveals turbulence suppression through a complex multi-scale mechanism that generates large-scale zonal flows. This holds promise for more economical operation of fusion reactors with dominant alpha particle heating and ultimately cheaper fusion electricity.
Published: 2022
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50. Disruption prediction with artificial intelligence techniques in tokamak plasmas

Author: Vega, J, Murari, A, Dormido-Canto, S, Ratta, G, Gelfusa, M, Mailloux, J, Abid, N, Abraham, K, Abreu, P, Adabonyan, O, Adrich, P, Afanasev, V, Afzal, M, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Akhtar, M, Albanese, R, Alderson-Martin, M, Alegre, D, Aleiferis, S, Aleksa, A, Alekseev, A, Alessi, E, Aleynikov, P, Algualcil, J, Ali, M, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, E, Andrew, P, Angelini, B, Angioni, C, Antoniou, I, Appel, L, Appelbee, C, Aria, S, Ariola, M, Artaserse, G, Arter, W, Artigues, V, Asakura, N, Ash, A, Ashikawa, N, Aslanyan, V, Astrain, M, Asztalos, O, Auld, D, Auriemma, F, Austin, Y, Avotina, L, Aymerich, E, Baciero, A, Bairaktaris, F, Balbin, J, Balbinot, L, Balboa, I, Balden, M, Balshaw, C, Balshaw, N, Bandaru, V, Banks, J, Baranov, Y, Barcellona, C, Barnard, A, Barnard, M, Barnsley, R, Barth, A, Baruzzo, M, Barwell, S, Bassan, M, Batista, A, Batistoni, P, Baumane, L, Bauvir, B, Baylor, L, Beaumont, P, Beckett, D, Begolli, A, Beidler, M, Bekris, N, Beldishevski, M, Belli, E, Belli, F, Belonohy, E, Yaala, M, Benayas, J, Bentley, J, Bergsaker, H, Bernardo, J, Bernert, M, Berry, M, Bertalot, L, Betar, H, Beurskens, M, Bickerton, S, Bieg, B, Bielecki, J, Bierwage, A, Biewer, T, Bilato, R, Bilkova, P, Birkenmeier, G, Bishop, H, Bizarro, J, Blackburn, J, Blanchard, P, Blatchford, P, Bobkov, V, Boboc, A, Bohm, P, Bohm, T, Bolshakova, I, Bolzonella, T, Bonanomi, N, Bonfiglio, D, Bonnin, X, Bonofiglo, P, Boocock, S, Booth, A, Booth, J, Borba, D, Borodin, D, Borodkina, I, Boulbe, C, Bourdelle, C, Bowden, M, Boyd, K, Bozicevic Mihalic, I, Bradnam, S, Braic, V, Brandt, L, Bravanec, R, Breizman, B, Brett, A, Brezinsek, S, Brix, M, Bromley, K, Brown, B, Brunetti, D, Buckingham, R, Buckley, M, Budny, R, Buermans, J, Bufferand, H, Buratti, P, Burgess, A, Buscarino, A, Busse, A, Butcher, D, de la Cal, E, Calabro, G, Calacci, L, Calado, R, Camenen, Y, Canal, G, Cannas, B, Cappelli, M, Carcangiu, S, Card, P, 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P., Greuner H., Grierson B., Griffiths J., Griph S., Grist D., Gromelski W., Groth M., Grove R., Gruca M., Guard D., Gupta N., Gurl C., Gusarov A., Hackett L., Hacquin S., Hager R., Hagg L., Hakola A., Halitovs M., Hall S., Hall S. A., Hallworth-Cook S., Ham C. J., Hamaguchi D., Hamed M., Hamlyn-Harris C., Hammond K., Harford E., Harrison J. R., Harting D., Hatano Y., Hatch D. R., Haupt T., Hawes J., Hawkes N. C., Hawkins J., Hayashi T., Hazael S., Hazel S., Heesterman P., Heidbrink B., Helou W., Hemming O., Henderson S. S., Henriques R. B., Hepple D., Herfindal J., Hermon G., Hill J., Hillesheim J. C., Hizanidis K., Hjalmarsson A., Ho A., Hobirk J., Hoenen O., Hogben C., Hollingsworth A., Hollis S., Hollmann E., Holzl M., Homan B., Hook M., Hopley D., Hora:ek J., Horsley D., Horsten N., Horton A., Horton L. D., Horvath L., Hotchin S., Howell R., Hu Z., Huber A., Huber V., Huddleston T., Huijsmans G. T. A., Huynh P., Hynes A., Iliasova M., lmrie D., lmrisek M., lngleby J., Innocente P., Bjork K. I., Isernia N., lvanova-Stanik I., lvings E., Jablonski S., Jachmich S., Jackson T., Jacquet P., Jarleblad H., Jaulmes F., Rodriguez J. J., Jepu I., Joffrin E., Johnson R., Johnson T., Johnston J., Jones C., Jones G., Jones L., Jones N., Jones T., Joyce A., Juarez R., Juvonen M., Kalnina P., Kaltiaisenaho T., Kaniewski J., Kantor A., Kappatou A., Karhunen J., Karkinsky D., Kashchuk Y., Kaufman M., Kaveney G., Kazakov Y. E. O., Kazantzidis V., Keeling D. L., Kelly R., Kempenaars M., Kennedy C., Kennedy D., Kent J., Khan K., Khilkevich E., Kiefer C., Kilpelainen J., Kim C., Kim H. -T., Kim S. H., King D. B., King R., Kinna D., Kiptily V. G., Kirjasuo A., Kirov K. 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F., Matveev D., Matveeva E., Mauriya A., Maviglia F., Mayer M., Mayoral M. -L., Mazzi S., Mazzotta C., McAdams R., McCarthy P. J., McClements K. G., McClenaghan J., McCullen P., McDonald D. C., McGuckin D., McHugh D., Mclntyre G., McKean R., McKehon J., McMillan B., McNamee L., McShee A., Meakins A., Medley S., Meekes C. J., Meghani K., Meigs A. G., Meisl G., Meitner S., Menmuir S., Mergia K., Merriman S., Mertens P., Meshchaninov S., Messiaen A., Michling R., Middleton P., Middleton-Gear D., Mietelski J., Milanesio D., Milani E., Militello F., Asp A. M., Milnes J., Milocco A., Miloshevsky G., Minghao C., Minucci S., Miron I., Miyamoto M., Mlynar J., Moiseenko V., Monaghan P., Monakhov I., Moody T., Moon S., Mooney R., Moradi S., Morales J., Morales R. 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A., Huynh P., Hynes A., Iliasova M., lmrie D., lmrisek M., lngleby J., Innocente P., Bjork K. I., Isernia N., lvanova-Stanik I., lvings E., Jablonski S., Jachmich S., Jackson T., Jacquet P., Jarleblad H., Jaulmes F., Rodriguez J. J., Jepu I., Joffrin E., Johnson R., Johnson T., Johnston J., Jones C., Jones G., Jones L., Jones N., Jones T., Joyce A., Juarez R., Juvonen M., Kalnina P., Kaltiaisenaho T., Kaniewski J., Kantor A., Kappatou A., Karhunen J., Karkinsky D., Kashchuk Y., Kaufman M., Kaveney G., Kazakov Y. E. O., Kazantzidis V., Keeling D. L., Kelly R., Kempenaars M., Kennedy C., Kennedy D., Kent J., Khan K., Khilkevich E., Kiefer C., Kilpelainen J., Kim C., Kim H. -T., Kim S. H., King D. B., King R., Kinna D., Kiptily V. G., Kirjasuo A., Kirov K. 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Abstract: In nuclear fusion reactors, plasmas are heated to very high temperatures of more than 100 million kelvin and, in so-called tokamaks, they are confined by magnetic fields in the shape of a torus. Light nuclei, such as deuterium and tritium, undergo a fusion reaction that releases energy, making fusion a promising option for a sustainable and clean energy source. Tokamak plasmas, however, are prone to disruptions as a result of a sudden collapse of the system terminating the fusion reactions. As disruptions lead to an abrupt loss of confinement, they can cause irreversible damage to present-day fusion devices and are expected to have a more devastating effect in future devices. Disruptions expected in the next-generation tokamak, ITER, for example, could cause electromagnetic forces larger than the weight of an Airbus A380. Furthermore, the thermal loads in such an event could exceed the melting threshold of the most resistant state-of-the-art materials by more than an order of magnitude. To prevent disruptions or at least mitigate their detrimental effects, empirical models obtained with artificial intelligence methods, of which an overview is given here, are commonly employed to predict their occurrence—and ideally give enough time to introduce counteracting measures.
Published: 2022

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