Search

Your search keyword '"McCoy,F"' showing total 262 results
Start Over Author "McCoy,F"
262 results on '"McCoy,F"'

15. Site 353: Vema Fracture Zone

Author

Perch-Nielsen, K., primary, Supko, P.R., additional, Boersma, A., additional, Bonatti, E., additional, Carlson, R.L., additional, McCoy, F., additional, Neprochnov, Y.P., additional, and Zimmerman, H.B., additional

Published
1977
Full Text
View/download PDF

16. Site 355: Brazil Basin

Author

Perch-Nielsen, K., primary, Supko, P.R., additional, Boersma, A., additional, Bonatti, E., additional, Carlson, R.L., additional, Dinkelman, M.G., additional, Fodor, R.B., additional, Kumar, N., additional, McCoy, F., additional, Thiede, J., additional, and Zimmerman, H.B., additional

Published
1977
Full Text
View/download PDF

18. Site 354: Ceara Rise

Author

Perch-Nielsen, K., primary, Supko, P.R., additional, Boersma, A., additional, Bonatti, E., additional, Carlson, R.L., additional, McCoy, F., additional, Neprochnov, Y.P., additional, and Zimmerman, H.B., additional

Published
1977
Full Text
View/download PDF

19. Site 358: Argentine Basin

Author

Perch-Nielsen, K., primary, Supko, P.R., additional, Boersma, A., additional, Bonatti, E., additional, Carlson, R.L., additional, Dinkelman, M.G., additional, Fodor, R.B., additional, Kumar, N., additional, McCoy, F., additional, Thiede, J., additional, and Zimmerman, H.B., additional

Published
1977
Full Text
View/download PDF

21. Site 357: Rio Grande Rise

Author

Perch-Nielsen, K., primary, Supko, P.R., additional, Boersma, A., additional, Bonatti, E., additional, Carlson, R.L., additional, Dinkelman, M.G., additional, Fodor, R.B., additional, Kumar, N., additional, McCoy, F., additional, Thiede, J., additional, and Zimmerman, H.B., additional

Published
1977
Full Text
View/download PDF

24. Site 359: Walvis Ridge (Seamount)

Author

Perch-Nielsen, K., primary, Supko, P.R., additional, Boersma, A., additional, Bonatti, E., additional, Carlson, R.L., additional, Dinkelman, M.G., additional, Fodor, R.B., additional, Kumar, N., additional, McCoy, F., additional, Thiede, J., additional, and Zimmerman, H.B., additional

Published
1977
Full Text
View/download PDF

25. Site 356: Sao Paulo Plateau

Author

Perch-Nielsen, K., primary, Supko, P.R., additional, Boersma, A., additional, Bonatti, E., additional, Carlson, R.L., additional, Dinkelman, M.G., additional, Fodor, R.B., additional, Kumar, N., additional, McCoy, F., additional, Thiede, J., additional, and Zimmerman, H.B., additional

Published
1977
Full Text
View/download PDF

26. Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer

Author

Paul, I, Chacko, A D, Stasik, Izabela, Busacca, S, Crawford, N, McCoy, F, McTavish, N, Wilson, B, Barr, M, O'Byrne, K J, Longley, D B, Fennell, D A, Paul, I, Chacko, A D, Stasik, Izabela, Busacca, S, Crawford, N, McCoy, F, McTavish, N, Wilson, B, Barr, M, O'Byrne, K J, Longley, D B, and Fennell, D A

Abstract

Failure to efficiently induce apoptosis contributes to cisplatin resistance in non-small-cell lung cancer (NSCLC). Although BCL-2-associated X protein (BAX) and BCL-2 antagonist killer (BAK) are critical regulators of the mitochondrial apoptosis pathway, their requirement has not been robustly established in relation to cisplatin. Here, we show that cisplatin can efficiently bypass mitochondrial apoptosis block caused by loss of BAX and BAK, via activation of the extrinsic death receptor pathway in some model cell lines. Apoptosis resistance following cisplatin can only be observed when both extrinsic and intrinsic pathways are blocked, consistent with redundancy between mitochondrial and death receptor pathways in cisplatin-induced apoptosis. In H460 NSCLC cells, caspase-8 cleavage was shown to be induced by cisplatin and is dependent on death receptor 4, death receptor 5, Fas-associated protein with death domain, acid sphingomyelinase and ceramide synthesis. In contrast, cisplatin-resistant cells fail to activate caspase-8 via this pathway despite conserving sensitivity to death ligand-driven activation. Accordingly, caspase-8 activation block acquired during cisplatin resistance, can be bypassed by death receptor agonism.

Published
2012

27. Acquired differential regulation of caspase-8 in cisplatin-resistant non-small-cell lung cancer

Author

Paul, Ian, Chacko, A., Stasik, Izabela, Busacca, Sara, Crawford, N., McCoy, F., McTavish, N., Wilson, B., Barr, Martin, O'Byrne, Kenneth, Longley, Daniel, Fennell, Dean, Paul, Ian, Chacko, A., Stasik, Izabela, Busacca, Sara, Crawford, N., McCoy, F., McTavish, N., Wilson, B., Barr, Martin, O'Byrne, Kenneth, Longley, Daniel, and Fennell, Dean

Abstract

Failure to efficiently induce apoptosis contributes to cisplatin resistance in non-small-cell lung cancer (NSCLC). Although BCL-2-associated X protein (BAX) and BCL-2 antagonist killer (BAK) are critical regulators of the mitochondrial apoptosis pathway, their requirement has not been robustly established in relation to cisplatin. Here, we show that cisplatin can efficiently bypass mitochondrial apoptosis block caused by loss of BAX and BAK, via activation of the extrinsic death receptor pathway in some model cell lines. Apoptosis resistance following cisplatin can only be observed when both extrinsic and intrinsic pathways are blocked, consistent with redundancy between mitochondrial and death receptor pathways in cisplatin-induced apoptosis. In H460 NSCLC cells, caspase-8 cleavage was shown to be induced by cisplatin and is dependent on death receptor 4, death receptor 5, Fas-associated protein with death domain, acid sphingomyelinase and ceramide synthesis. In contrast, cisplatin-resistant cells fail to activate caspase-8 via this pathway despite conserving sensitivity to death ligand-driven activation. Accordingly, caspase-8 activation block acquired during cisplatin resistance, can be bypassed by death receptor agonism.

Published
2012

36. Association between somatic cell count early in the first lactation and the longevity of Irish dairy cows.

Author

Archer, S. C., McCoy, F., Wapenaar, W., and Green, M. J.

Subjects
*CATTLE, *SOMATIC cells, *BOVINE mastitis, *MILK, *DAIRY cattle
Abstract

Reduced longevity of cows is an important component of mastitis costs, and increased somatic cell count (SCC) early in the first lactation has been reported to increase culling risk throughout the first lactation. Generally, cows must survive beyond the first lactation to break even on their rearing costs. The aim of this research was to assess the association between SCC of primiparous cows at 5 to 30 days in milk (SCC1), and survival over a 5-y period for cows in Irish dairy herds. The data set used for model development was based on 147,458 test day records from 7,537 cows in 812 herds. Cows were censored at their last recording if identified at a later date in other herds or if recorded at the last available test date for their herd, otherwise, date of disposal was taken to be at the last test date for each cow. Survival time was calculated as the number of days between the dates of first calving and the last recording, which was split into 50-d intervals. Data were analyzed in discrete time logistic survival models that accounted for clustering of 50-d intervals within cows, and cows within herds. Models were fitted in a Bayesian framework using Markov chain Monte Carlo simulations. Model fit was assessed by comparison of posterior predictions to the observed disposal risk for cows aggregated by parameters in the model. Model usefulness was assessed by cross validation in a separate data set, which contained 144,113 records from 7,353 cows in 808 herds, and posterior predictions were compared with the observed disposal risk for cows aggregated by parameters of biological importance. Disposal odds increased by a factor of 5% per unit increase in ln SCC1. Despite this, posterior predictive distributions revealed that the probability of reducing replacement costs by >€10 per heifer calved, through decreasing the herd level prevalence of cows with SCC1 ≥400,000 cells/mL (from an initial prevalence of ≥20 to <10%) only exceeded 50% for less than 1 in 5 Irish herds. These results indicate that the effect of a reduction in the prevalence of cows with SCC1 ≥400,000 cells/mL on replacement costs alone for most Irish dairy herds is small, and future research should investigate other potential losses, such as the effect of SCC1 on lifetime milk yield. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

43. A decade in review.

Author

McCoy, F.

Subjects
*ECONOMICS
Abstract

Presents `Black Enterprise' magazine's (B.E.) Board of Economists' (BEBE) review of the past decade and forces that impact on the economic development of black America. The view that the recession is over; Factors that are complicating the recovery; Unemployment rate in February 1992; Paper delivered at the BEBE convention by Dr. Bernard E. Anderson of the Philadelphia-based Anderson Group; Average annual unemployment rate 1981-91 for blacks, Hispanics and whites.

Published
1992

44. Wall street wizards.

Author

McCoy, F.

Subjects
*STOCK exchanges
Abstract

Highlights a roundtable of four of the country's most astute stock pickers, which was convened by `Black Enterprise' in December of 1992. Questions about their views of the economy; The economy's impact on the equities market; Investments in theconsumer and health care industries. INSET: Brown Capital Management Inc.; Woodford Capital Management Inc....

Published
1992

45. Face-off: The battle for black America's vote.

Author

McCoy, F.

Subjects
BROWN, Ronald Harmon, 1941-1996
Abstract

Presents interviews with Democratic National Chairman Ron Brown and Republican National Committee Chairman Clayton K. Yeuter. Brown's new strategy to recapture the executive branch; Yeuter's views of Bush's chances; Brown's view of President George Bush's vulnerability; Specific Democratic planks; Why the GOP favors a cut in capital gains taxes; More.

Published
1992

46. Power surge.

Author

McCoy, F.

Subjects
*EXECUTIVES
Abstract

Focuses on people who have been featured in `Black Enterprise' as the most powerful African-American executives in corporate America. Promotions achieved by these people since 1988; Dorothy A. Terrell, president of Sun Express; Sylvia Rhone, chairperson and CEO of ATCO-EastWest; Dennis F. Hightower, president of Disney Consumer Products, Europe and the Middle East; More.

Published
1992

47. Achieving growth in a slowly reviving economy.

Author

McCoy, F.

Subjects
*ECONOMICS, UNITED States economy
Abstract

Focuses on discussions among the `Black Enterprise' Board of Economists, which convened in Washington D.C., last September. Reasons for doubt and wariness in the economy; Projected descent of inflation; Talk about education's role in determining employment and income; Challenges facing African-American mayors; Board members; Deterioration in the relative economic position of black Americans over the last year; Comment of David Swinton, of Jackson State University; More.

Published
1992

48. Spotting a new bull market.

Author

McCoy, F.

Subjects
*INVESTMENTS
Abstract

Presents the outlook of market analysts who were surveyed by `Black Enterprise' and gives some of their stock selections. Possible winners in stocks, bonds, mutual funds and real estate for 1992; Tere Alvarez Canida, president and director, Taplin, Canida & Habacht, Miami; Alan Bond, senior portfolio manager, W.R. Lazard & Co., New York; Eddie C. Brown, president, Brown Capital Management Inc.; More.

Published
1991

49. The world's biggest fire sale.

Author

McCoy, F.

Subjects
RESOLUTION Trust Corp. (U.S.)
Abstract

Evaluates the opportunities for minority businesses for receiving a fair share of the $100 billion in savings and loans assets being disposed of by the Resolution Trust Corporation (RTC). History of the RTC; Current status; Indications that minorities are not being selected to do bailout-related work; How to improve the situation. INSET: For more information about the RTC..

Published
1991

50. Riding out the recession.

Author

McCoy, F.

Subjects
*BUSINESS
Abstract

Advises black businesses on how to battle for sales and market share during the present recession. Recommendations made by the `Black Enterprise' Board of Economists; Analysis of industries most and least affected by the recession; Key factors weakening black income growth; Success stories of black companies that have survived and grown; Prognosis for 1991.

Published
1991

Catalog

Books, media, physical & digital resources
See catalog results