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2. Quantum Computing at the Frontiers of Biological Sciences

Author

Emani, Prashant S., Warrell, Jonathan, Anticevic, Alan, Bekiranov, Stefan, Gandal, Michael, McConnell, Michael J., Sapiro, Guillermo, Aspuru-Guzik, Alán, Baker, Justin, Bastiani, Matteo, McClure, Patrick, Murray, John, Sotiropoulos, Stamatios N, Taylor, Jacob, Senthil, Geetha, Lehner, Thomas, Gerstein, Mark B., and Harrow, Aram W.

Subjects
Quantum Physics, Quantitative Biology - Genomics, Quantitative Biology - Neurons and Cognition, Quantitative Biology - Quantitative Methods
Abstract

The search for meaningful structure in biological data has relied on cutting-edge advances in computational technology and data science methods. However, challenges arise as we push the limits of scale and complexity in biological problems. Innovation in massively parallel, classical computing hardware and algorithms continues to address many of these challenges, but there is a need to simultaneously consider new paradigms to circumvent current barriers to processing speed. Accordingly, we articulate a view towards quantum computation and quantum information science, where algorithms have demonstrated potential polynomial and exponential computational speedups in certain applications, such as machine learning. The maturation of the field of quantum computing, in hardware and algorithm development, also coincides with the growth of several collaborative efforts to address questions across length and time scales, and scientific disciplines. We use this coincidence to explore the potential for quantum computing to aid in one such endeavor: the merging of insights from genetics, genomics, neuroimaging and behavioral phenotyping. By examining joint opportunities for computational innovation across fields, we highlight the need for a common language between biological data analysis and quantum computing. Ultimately, we consider current and future prospects for the employment of quantum computing algorithms in the biological sciences., Comment: 22 pages, 3 figures, Perspective

Published
2019
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3. Pharmacological reactivation of inactive X-linked Mecp2 in cerebral cortical neurons of living mice.

Author

Przanowski, Piotr, Wasko, Urszula, Zheng, Zeming, Yu, Jun, Sherman, Robyn, Zhu, Lihua Julie, McConnell, Michael J, Tushir-Singh, Jogender, Green, Michael R, and Bhatnagar, Sanchita

Subjects
Cerebral Cortex, Neurons, Cell Line, Animals, Mice, Knockout, Humans, Mice, Rett Syndrome, Mutation, Methyl-CpG-Binding Protein 2, Mecp2, Rett syndrome, X chromosome reactivation, brain neurons, mouse model, Pediatric, Brain Disorders, Neurodegenerative, Stem Cell Research, Neurosciences, Stem Cell Research - Nonembryonic - Human, Genetics, Rare Diseases, 5.2 Cellular and gene therapies, Development of treatments and therapeutic interventions, Congenital
Abstract

Rett syndrome (RTT) is a genetic disorder resulting from a loss-of-function mutation in one copy of the X-linked gene methyl-CpG-binding protein 2 (MECP2). Typical RTT patients are females and, due to random X chromosome inactivation (XCI), ∼50% of cells express mutant MECP2 and the other ∼50% express wild-type MECP2. Cells expressing mutant MECP2 retain a wild-type copy of MECP2 on the inactive X chromosome (Xi), the reactivation of which represents a potential therapeutic approach for RTT. Previous studies have demonstrated reactivation of Xi-linked MECP2 in cultured cells by biological or pharmacological inhibition of factors that promote XCI (called "XCI factors" or "XCIFs"). Whether XCIF inhibitors in living animals can reactivate Xi-linked MECP2 in cerebral cortical neurons, the cell type most therapeutically relevant to RTT, remains to be determined. Here, we show that pharmacological inhibitors targeting XCIFs in the PI3K/AKT and bone morphogenetic protein signaling pathways reactivate Xi-linked MECP2 in cultured mouse fibroblasts and human induced pluripotent stem cell-derived postmitotic RTT neurons. Notably, reactivation of Xi-linked MECP2 corrects characteristic defects of human RTT neurons including reduced soma size and branch points. Most importantly, we show that intracerebroventricular injection of the XCIF inhibitors reactivates Xi-linked Mecp2 in cerebral cortical neurons of adult living mice. In support of these pharmacological results, we also demonstrate genetic reactivation of Xi-linked Mecp2 in cerebral cortical neurons of living mice bearing a homozygous XCIF deletion. Collectively, our results further establish the feasibility of pharmacological reactivation of Xi-linked MECP2 as a therapeutic approach for RTT.

Published
2018

5. Quantum computing at the frontiers of biological sciences

Author

Emani, Prashant S., Warrell, Jonathan, Anticevic, Alan, Bekiranov, Stefan, Gandal, Michael, McConnell, Michael J., Sapiro, Guillermo, Aspuru-Guzik, Alán, Baker, Justin T., Bastiani, Matteo, Murray, John D., Sotiropoulos, Stamatios N., Taylor, Jacob, Senthil, Geetha, Lehner, Thomas, Gerstein, Mark B., and Harrow, Aram W.

Published
2021
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6. Deep Intraclonal Analysis for the Development of Vaccines against Drug-Resistant Klebsiella pneumoniae Lineages.

Author

Tajuelo, Ana, Gato, Eva, Oteo-Iglesias, Jesús, Pérez-Vázquez, María, McConnell, Michael J., Martín-Galiano, Antonio J., and Pérez, Astrid

Subjects
KLEBSIELLA infections, KLEBSIELLA pneumoniae, VACCINE development, GUT microbiome, DRUG resistance in bacteria
Abstract

Despite its medical relevance, there is no commercial vaccine that protects the population at risk from multidrug-resistant (MDR) Klebsiella pneumoniae infections. The availability of massive omic data and novel algorithms may improve antigen selection to develop effective prophylactic strategies. Up to 133 exposed proteins in the core proteomes, between 516 and 8666 genome samples, of the six most relevant MDR clonal groups (CGs) carried conserved B-cell epitopes, suggesting minimized future evasion if utilized for vaccination. Antigens showed a range of epitopicity, functional constraints, and potential side effects. Eleven antigens, including three sugar porins, were represented in all MDR-CGs, constitutively expressed, and showed limited reactivity with gut microbiota. Some of these antigens had important interactomic interactions and may elicit adhesion-neutralizing antibodies. Synergistic bivalent to pentavalent combinations that address expression conditions, interactome location, virulence activities, and clone-specific proteins may overcome the limiting protection of univalent vaccines. The combination of five central antigens accounted for 41% of all non-redundant interacting partners of the antigen dataset. Specific antigen mixtures represented in a few or just one MDR-CG further reduced the chance of microbiota interference. Rational antigen selection schemes facilitate the design of high-coverage and "magic bullet" multivalent vaccines against recalcitrant K. pneumoniae lineages. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Loss of Lipooligosaccharide Synthesis in Acinetobacter baumannii Produces Changes in Outer Membrane Vesicle Protein Content.

Author

Cano-Castaño, Beatriz, Corral-Lugo, Andrés, Gato, Eva, Terrón, María C., Martín-Galiano, Antonio J., Sotillo, Javier, Pérez, Astrid, and McConnell, Michael J.

Subjects
EXTRACELLULAR vesicles, GEL permeation chromatography, ACINETOBACTER baumannii, PROTEIN overexpression, GRAM-negative bacteria
Abstract

Outer membrane vesicles (OMVs) are nanostructures derived from the outer membrane of Gram-negative bacteria. We previously demonstrated that vaccination with endotoxin-free OMVs isolated from an Acinetobacter baumannii strain lacking lipooligosaccharide (LOS) biosynthesis, due to a mutation in lpxD, provides full protection in a murine sepsis model. The present study characterizes the protein content of highly-purified OMVs isolated from LOS-replete and LOS-deficient strains. Four purification methods were evaluated to obtain highly purified OMV preparations: ultracentrifugation, size exclusion chromatography (SEC), ultracentrifugation followed by SEC, and Optiprep™. OMVs from each method were characterized using nanoparticle tracking analysis and electron microscopy. OMVs from LOS-deficient and LOS-replete strains purified using the Optiprep™ method were subjected to LC-MS/MS analysis to determine protein content. Significant differences in protein composition between OMVs from LOS-deficient and LOS-replete strains were found. Computational analyses using Bepipred 3.0 and SEMA 2.0 indicated that the lack of LOS led to the overexpression of immunogenic proteins found in LOS-containing OMVs and the presence of immune-stimulating proteins absent in LOS-replete OMVs. These findings have important implications for developing OMV-based vaccines against A. baumannii, using both LOS-containing and LOS-free OMVs preparations. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

Author

Brennand, Kristen J, Marchetto, M Carol, Benvenisty, Nissim, Brüstle, Oliver, Ebert, Allison, Belmonte, Juan Carlos Izpisua, Kaykas, Ajamete, Lancaster, Madeline A, Livesey, Frederick J, McConnell, Michael J, McKay, Ronald D, Morrow, Eric M, Muotri, Alysson R, Panchision, David M, Rubin, Lee L, Sawa, Akira, Soldner, Frank, Song, Hongjun, Studer, Lorenz, Temple, Sally, Vaccarino, Flora M, Wu, Jun, Vanderhaeghen, Pierre, Gage, Fred H, and Jaenisch, Rudolf

Subjects
Biochemistry and Cell Biology, Biological Sciences, Brain Disorders, Bioengineering, Neurosciences, Clinical Research, Stem Cell Research, Neurological, Brain, Brain Diseases, Drug Discovery, Humans, Induced Pluripotent Stem Cells, Mosaicism, Neurogenesis, Precision Medicine, Clinical Sciences, Biochemistry and cell biology
Abstract

As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field.

Published
2015

18. Intersection of diverse neuronal genomes and neuropsychiatric disease : The Brain Somatic Mosaicism Network

Author

Brain Somatic Mosaicism Network, McConnell, Michael J., Moran, John V., Abyzov, Alexej, Akbarian, Schahram, Bae, Taejeong, Cortes-Ciriano, Isidro, Erwin, Jennifer A., Fasching, Liana, Flasch, Diane A., Freed, Donald, Ganz, Javier, Jaffe, Andrew E., Kwan, Kenneth Y., Kwon, Minseok, Lodato, Michael A., Mills, Ryan E., Paquola, Apua C. M., Rodin, Rachel E., Rosenbluh, Chaggai, Sestan, Nenad, Sherman, Maxwell A., Shin, Joo Heon, Song, Saera, Straub, Richard E., Thorpe, Jeremy, Weinberger, Daniel R., Urban, Alexander E., Zhou, Bo, Gage, Fred H., Lehner, Thomas, Senthil, Geetha, A. Walsh, Christopher, Chess, Andrew, Courchesne, Eric, Gleeson, Joseph G., Kidd, Jeffrey M., Park, Peter J., Pevsner, Jonathan, and Vaccarino, Flora M.

Published
2017

24. Fecal carriage of extended-spectrum beta-lactamase-producing Enterobacterales in healthy Spanish schoolchildren

Author

López-Siles, Mireia, primary, Moure, Zaira, additional, Muadica, Aly Salimo, additional, Sánchez, Sergio, additional, Cruces, Raquel, additional, Ávila, Alicia, additional, Lara, Noelia, additional, Köster, Pamela Carolina, additional, Dashti, Alejandro, additional, Oteo-Iglesias, Jesús, additional, Carmena, David, additional, and McConnell, Michael J., additional

Published
2023
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30. Mapping the Complex Genetic Landscape of Human Neurons

Author

Sun, Chen, Kathuria, Kunal, Emery, Sarah B, Kim, ByungJun, Burbulis, Ian E., Shin, Joo Heon, Weinberger, Daniel R., Moran, John V., Kidd, Jeffrey M., Mills, Ryan E., and McConnell, Michael J.

Subjects
Article
Abstract

When somatic cells acquire complex karyotypes, they are removed by the immune system. Mutant somatic cells that evade immune surveillance can lead to cancer. Neurons with complex karyotypes arise during neurotypical brain development, but neurons are almost never the origin of brain cancers. Instead, somatic mutations in neurons can bring about neurodevelopmental disorders, and contribute to the polygenic landscape of neuropsychiatric and neurodegenerative disease. A subset of human neurons harbors idiosyncratic copy number variants (CNVs, “CNV neurons”), but previous analyses of CNV neurons have been limited by relatively small sample sizes. Here, we developed an allele-based validation approach, SCOVAL, to corroborate or reject read-depth based CNV calls in single human neurons. We applied this approach to 2,125 frontal cortical neurons from a neurotypical human brain. This approach identified 226 CNV neurons, as well as a class of CNV neurons with complex karyotypes containing whole or substantial losses on multiple chromosomes. Moreover, we found that CNV location appears to be nonrandom. Recurrent regions of neuronal genome rearrangement contained fewer, but longer, genes.

Published
2023

31. Desarrollo preclínico de una vacuna de ADN contra la infección por Klebsiella pneumoniae

Author

López Siles, Mireia, Vicente Pazos, Marta, Navarro Sánchez, Clàudia, and McConnell, Michael J

Subjects
Klebsiella pneumoniae, resistencia a antibióticos, vacunas de ADN, inmunogenicidad, subunidades fimbriales
Abstract

Resumen Introducción y objetivo.Klebsiella pneumoniaese encuentra entre los patógenos considerados de prioridad crítica por la OMS. Durante las últimas tres décadas se ha incrementado el número de infecciones causadas por esta especie y han aparecido cepas resistentes a múltiples antibióticos, lo que representa un importante problema clínico tanto a nivel hospitalario como comunitario. Debido a esta situación, el desarrollo de vacunas presenta un importante potencial para prevenir las infecciones causadas por este microorganismo y reducir la mortalidad y morbilidad asociadas a sus infecciones. El objetivo de este estudio fue construir vacunas de ADN que expresan diferentes proteínas deK. pneumoniaeen células eucariotas y evaluar su inmunogenicidadin vivo. Material y métodos.Se realizó una búsqueda bibliográfica, análisis y selección de proteínas candidatas a antígenos vacunales frente aK. pneumoniae. Las proteínas seleccionadas fueron analizadas bioinformáticamente para determinar la similitud de secuencia entreKlebsiellasp., y predecir los epítopos reconocidos por linfocitos B y T mediante las plataformas VaxiJen 2.0 y ABCpred. La secuencia de estos antígenos fue adaptada para su expresión en células humanas y se fusionaron a elementos inmunoestimuladores. Los antígenos candidatos seleccionados se clonaron de forma independiente en la plataforma de ADN pVAX1 (Thermo Fisher Scientific). La expresiónin vitrode antígenos se comprobó mediante transfección de células eucariotas HEK-293T y Western Blot. Los candidatos vacunales resultantes, así como sus controles negativos, correspondientes al plásmido sin secuencia antigénica, se inyectaron a ratones por vía intramuscular y se midieron los niveles de IgM, IgG total y subtipos de IgG (IgG1, IgG2a, IgG3) mediante ELISA. La tasa de supervivencia se estableció en un modelo de ratones con sepsis porK. pneumoniae. Resultados.Se identificaron un total de 34 posibles proteínas candidatas, de las cuales 8 se ajustaron a los criterios de selección para ser buenos antígenos. Estos candidatos se clasificaron en 4 categorías: 1) porinas específicas (n=2), 2) sideróforos (n=3), 3) proteínas de membrana externa (n=2), y 4) fimbrias (n=1). Se detectó la expresión de dos antígenos (porinas y fimbrias) en la fracción celular y en el sobrenadante de células HEK-293T. Los niveles de anticuerpos obtenidos fueron más altos para la vacuna basada en porinas que para la vacuna de subunidad fimbral. Los anticuerpos de IgG generados por ambas vacunas incluyeron IgG1, IgG2a, IgG2b e IgG3. Los ratones inmunizados exhibieron un predominio de IgG1 sobre IgG2a, lo que indica una respuesta principalmente de tipo humoral. Sin embargo, la mejor tasa de supervivencia se logró para la vacuna basada en fimbrias. Conclusión.Este es el primer estudio que establece la inmunogenicidad de una vacuna de ADN basada en subunidades fimbriales contra infecciones porK. pneumoniae. Además, se observó que los niveles altos de inmunoglobulina no necesariamente se correlacionan con una mayor tasa de supervivencia después de la infección. El candidato vacunal desarrollado representa una estrategia prometedora para su aplicación profiláctica frente infecciones causadas porK. pneumoniae.

Published
2023
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35. Characterization of protective extracellular membrane-derived vesicles produced by Streptococcus pneumoniae

Author

Olaya-Abril, Alfonso, Prados-Rosales, Rafael, McConnell, Michael J., Martín-Peña, Reyes, González-Reyes, José Antonio, Jiménez-Munguía, Irene, Gómez-Gascón, Lidia, Fernández, Javier, Luque-García, José L., García-Lidón, Carlos, Estévez, Héctor, Pachón, Jerónimo, Obando, Ignacio, Casadevall, Arturo, Pirofski, Liise-anne, and Rodríguez-Ortega, Manuel J.

Published
2014
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37. Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis

Author

Song, SungWon, Miranda, Carlos J., Braun, Lyndsey, Meyer, Kathrin, Frakes, Ashley E., Ferraiuolo, Laura, Likhite, Shibi, Bevan, Adam K., Foust, Kevin D., McConnell, Michael J., Walker, Christopher M., and Kaspar, Brian K.

Subjects
HLA histocompatibility antigens -- Analysis, Amyotrophic lateral sclerosis -- Genetic aspects -- Analysis, Major histocompatibility complex -- Genetic aspects -- Analysis, Histocompatibility antigens -- Analysis, Biological sciences, Health
Abstract

Astrocytes isolated from individuals with amyotrophic lateral sclerosis (ALS) are toxic to motor neurons (MNs) and play a non-cell autonomous role in disease pathogenesis. The mechanisms underlying the susceptibility of MNs to cell death remain unclear. Here we report that astrocytes derived from either mice bearing mutations in genes associated with ALS or human subjects with ALS reduce the expression of major histocompatibility complex class I (MHCI) molecules on MNs; reduced MHCI expression makes these MNs susceptible to astrocyte-induced cell death. Increasing MHCI expression on MNs increases survival and motor performance in a mouse model of ALS and protects MNs against astrocyte toxicity. Overexpression of a single MHCI molecule, HLA-F, protects human MNs from ALS astrocyte-mediated toxicity, whereas knockdown of its receptor, the killer cell immunoglobulin-like receptor KIR3DL2, on human astrocytes results in enhanced MN death. Thus, our data indicate that, in ALS, loss of MHCI expression on MNs renders them more vulnerable to astrocyte-mediated toxicity., ALS is a fatal, adult-onset neurodegenerative disorder characterized by the progressive loss of MNs and death due to respiratory failure (1). The majority of cases are classified as sporadic ALS [...]

Published
2016
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38. Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons

Author

Krishnaswami, Suguna Rani, Grindberg, Rashel V, Novotny, Mark, Venepally, Pratap, Lacar, Benjamin, Bhutani, Kunal, Linker, Sara B, Pham, Son, Erwin, Jennifer A, Miller, Jeremy A, Hodge, Rebecca, McCarthy, James K, Kelder, Martijn, McCorrison, Jamison, Aevermann, Brian D, Fuertes, Francisco Diez, Scheuermann, Richard H, Lee, Jun, Lein, Ed S, Schork, Nicholas, McConnell, Michael J, Gage, Fred H, and Lasken, Roger S

Published
2016
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40. RNA-sequencing from single nuclei

Author

Grindberg, Rashel V., Yee-Greenbaum, Joyclyn L., McConnell, Michael J., Novotny, Mark, O'Shaughnessy, Andy L., Lambert, Georgina M., Araúzo-Bravo, Marcos J., Lee, Jun, Fishman, Max, Robbins, Gillian E., Lin, Xiaoying, Venepally, Pratap, Badger, Jonathan H., Galbraith, David W., Gage, Fred H., and Lasken, Roger S.

Published
2013

41. Mosaic Copy Number Variation in Human Neurons

Author

McConnell, Michael J., Lindberg, Michael R., Brennend, Kristen J., Piper, Julia C., Voet, Thierry, Cowing-Zitron, Chris, Shumilina, Svetlana, Lasken, Roger S., Vermeesch, Joris R., Hall, Ira M., and Gage, Fred H.

Published
2013
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42. Towards Control and Oversight of SARS-CoV-2 Diagnosis and Monitoring through Multiplexed Quantitative Electroanalytical Immune Response Biosensors

Author

Torrente Rodríguez, Rebeca Magnolia, Montero Calle, Ana, San Bartolomé, Clara, Cano, Olga, Vazquez, Monica, Iglesias Caballero, María, Corral Lugo, Andrés, McConnell, Michael J., Pascal, Mariona, Mas, Vicente, Pingarrón Carrazón, José Manuel, Barderas, Rodrigo, Campuzano Ruiz, Susana, Torrente Rodríguez, Rebeca Magnolia, Montero Calle, Ana, San Bartolomé, Clara, Cano, Olga, Vazquez, Monica, Iglesias Caballero, María, Corral Lugo, Andrés, McConnell, Michael J., Pascal, Mariona, Mas, Vicente, Pingarrón Carrazón, José Manuel, Barderas, Rodrigo, and Campuzano Ruiz, Susana

Abstract

CRUE-CSIC (Acuerdos Transformativos 2022), The development of versatile and sensitive biotools to quantify specific SARS-CoV-2 immunoglobulins in SARS-CoV-2 infected and non-infected individuals, built-on the surface of magnetic microbeads functionalized with nucleocapsid (N) and inhouse expressed recombinant spike (S) proteins is reported. Amperometric interrogation of captured N- and S-specific circulating total or individual immunoglobulin (Ig) isotypes (IgG, IgM, and IgA), subsequently labelled with HRP-conjugated secondary antibodies, was performed at disposable single or multiplexed (8) screen-printed electrodes using the HQ/HRP/H2O2 system. The obtained results using N and in-house expressed S ectodomains of five SARS-CoV-2 variants of concern (including the latest Delta and Omicron) allow identification of vulnerable populations from those with natural or acquired immunity, monitoring of infection, evaluation of vaccine efficiency and even identification of the variant responsible for the infection., Ministerio de Ciencia e Innovación (MICINN), Comunidad de Madrid, Instituto de Salud Carlos III (ISCIII), Depto. de Química Analítica, Fac. de Ciencias Químicas, TRUE, pub

Published
2022

44. Corrigendum: Brief Research Report: Virus-Specific Humoral Immunity at Admission Predicts the Development of Respiratory Failure in Unvaccinated SARS-CoV-2 Patients

Author

Tajuelo, Ana, primary, Carretero, Octavio, additional, García-Ríos, Estéfani, additional, López-Siles, Mireia, additional, Cano, Olga, additional, Vázquez, Mónica, additional, Más, Vicente, additional, Rodríguez-Goncer, Isabel, additional, Lalueza, Antonio, additional, López-Medrano, Francisco, additional, San Juan, Rafael, additional, Fernández-Ruiz, Mario, additional, Aguado, José M., additional, McConnell, Michael J., additional, and Pérez-Romero, Pilar, additional

Published
2022
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45. Towards Control and Oversight of SARS‐CoV‐2 Diagnosis and Monitoring through Multiplexed Quantitative Electroanalytical Immune Response Biosensors

Author

Torrente‐Rodríguez, Rebeca M., primary, Montero‐Calle, Ana, additional, San Bartolomé, Clara, additional, Cano, Olga, additional, Vázquez, Mónica, additional, Iglesias‐Caballero, María, additional, Corral‐Lugo, Andrés, additional, McConnell, Michael J., additional, Pascal, Mariona, additional, Mas, Vicente, additional, Pingarrón, José M., additional, Barderas, Rodrigo, additional, and Campuzano, Susana, additional

Published
2022
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47. Brief Research Report: Virus-Specific Humoral Immunity at Admission Predicts the Development of Respiratory Failure in Unvaccinated SARS-CoV-2 Patients

Author

Tajuelo, Ana, primary, Carretero, Octavio, additional, García-Ríos, Estéfani, additional, López-Siles, Mireia, additional, Cano, Olga, additional, Vázquez, Mónica, additional, Más, Vicente, additional, Rodríguez-Goncer, Isabel, additional, Lalueza, Antonio, additional, López-Medrano, Francisco, additional, San Juan, Rafael, additional, Fernández-Ruiz, Mario, additional, Aguado, José Mᵃ, additional, McConnell, Michael J., additional, and Pérez-Romero, Pilar, additional

Published
2022
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50. Correction: Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation

Author

Lacar, Benjamin, Linker, Sara B., Jaeger, Baptiste N., Krishnaswami, Suguna Rani, Barron, Jerika J., Kelder, Martijn J. E., Parylak, Sarah L, Paquola, Apuã C. M., Venepally, Pratap, Novotny, Mark, O’Connor, Carolyn, Fitzpatrick, Conor, Erwin, Jennifer A., Hsu, Jonathan Y., Husband, David, McConnell, Michael J., Lasken, Roger, and Gage, Fred H.

Published
2017
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