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8. Self-(In)compatibility Systems: Target Traits for Crop-Production, Plant Breeding, and Biotechnology

Author

Muñoz-Sanz, J.V., Zuriaga, E., Cruz-García, F., McClure, B., and Romero, Carlos

Subjects
fungi, food and beverages
Abstract

Self-incompatibility (SI) mechanisms prevent self-fertilization in flowering plants based on specific discrimination between self- and non-self pollen. Since this trait promotes outcrossing and avoids inbreeding it is a widespread mechanism of controlling sexual plant reproduction. Growers and breeders have effectively exploited SI as a tool for manipulating domesticated crops for thousands of years. However, only within the past thirty years have studies begun to elucidate the underlying molecular features of SI. The specific S-determinants and some modifier factors controlling SI have been identified in the sporophytic system exhibited by Brassica species and in the two very distinct gametophytic systems present in Papaveraceae on one side and in Solanaceae, Rosaceae, and Plantaginaceae on the other. Molecular level studies have enabled SI to SC transitions (and vice versa) to be intentionally manipulated using marker assisted breeding and targeted approaches based on transgene integration, silencing, and more recently CRISPR knock-out of SI-related factors. These scientific advances have, in turn, provided a solid basis to implement new crop production and plant breeding practices. Applications of self-(in)compatibility include widely differing objectives such as crop yield and quality improvement, marker-assisted breeding through SI genotyping, and development of hybrids for overcoming intra- and interspecific reproductive barriers. Here, we review scientific progress as well as patented applications of SI, and also highlight future prospects including further elucidation of SI systems, deepening our understanding of SI-environment relationships, and new perspectives on plant self/non-self recognition.

Published
2020

9. Self-(In)compatibility Systems: Target Traits for Crop-Production, Plant Breeding, and Biotechnology

Author

Muñoz-Sanz, Juan Vicente, Zuriaga, E., Cruz-García, F., McClure, B., Romero, Carlos, Muñoz-Sanz, Juan Vicente, Zuriaga, E., Cruz-García, F., McClure, B., and Romero, Carlos

Abstract

Self-incompatibility (SI) mechanisms prevent self-fertilization in flowering plants based on specific discrimination between self- and non-self pollen. Since this trait promotes outcrossing and avoids inbreeding it is a widespread mechanism of controlling sexual plant reproduction. Growers and breeders have effectively exploited SI as a tool for manipulating domesticated crops for thousands of years. However, only within the past thirty years have studies begun to elucidate the underlying molecular features of SI. The specific S-determinants and some modifier factors controlling SI have been identified in the sporophytic system exhibited by Brassica species and in the two very distinct gametophytic systems present in Papaveraceae on one side and in Solanaceae, Rosaceae, and Plantaginaceae on the other. Molecular level studies have enabled SI to SC transitions (and vice versa) to be intentionally manipulated using marker assisted breeding and targeted approaches based on transgene integration, silencing, and more recently CRISPR knock-out of SI-related factors. These scientific advances have, in turn, provided a solid basis to implement new crop production and plant breeding practices. Applications of self-(in)compatibility include widely differing objectives such as crop yield and quality improvement, marker-assisted breeding through SI genotyping, and development of hybrids for overcoming intra- and interspecific reproductive barriers. Here, we review scientific progress as well as patented applications of SI, and also highlight future prospects including further elucidation of SI systems, deepening our understanding of SI-environment relationships, and new perspectives on plant self/non-self recognition.

Published
2020

17. Irish Endocrine Society: Proceedings of 15th Annual Meeting, University College Hospital Galway, November 2nd–3rd, 1990

Author

O’Connell, Y., McKenna, T. J., Cunningham, S. K., Morrison, P. J., Hadden, D. R., Hughes, A. E., Kennedy, L., Russell, C. F. J., Nevin, N. C., Brennan, D., Powell, D., Bell, P. M., Neely, R. D. G., Rooney, D. P., Ennis, C. N., Sheridan, B., Atkinson, A. B., Trimble, E. R., Whitehead, H. M., Kennedy, A. L., Scanlan, P., Dowling, M., Dervan, P., Corrigan, T., Heffeman, S., Firth, R., O’Hare, J., Abuaisha, B., Barrett, E., Smyth, P. P. A., Hetherton, A. M., Ryan, R., Herlihy, C. O., Smith, A., Montwill, J., McCance, D. R., Fannin, T. F., Gordon, D. S., Fiad, T. M., Golden, J., Rollins, M. D., Jenkins, J. G., Carson, D. J., McClure, B. G., Keenan, P., Cregan, D., Wade, B., Stinson, J. C., Tighe, O., Tyndall, P., Owens, D., Collins, P., Johnson, A., Tomkin, G. H., Neery, R. D. G., Ennis, K., Trimble, E., McKnight, J. A., Roberts, G., Dunne, F. P., Barry, D. G., Ferriss, J. B., Grealy, G., Murphy, D., Traub, A. I., Leslie, H., Atkinson, R. J., Grimes, H., and Skehill, R.

Published
1991
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19. Selected abstracts

Author

Corkery, P. P., Leek, B. F., Caulfield, B., Garrett, M., Gormley, J. P., OʼDonnell, P. M., Kennedy, N., Sayers, K., Stokes, E., Bresnihan, B., Fitzgerald, O., McGarvey, M. A., Tonra, M., Hooper, A. C. B., Barry, J., Maurer, B., Hussey, J., Gormley, J., Noble, J. G., Alves-Guerreiro, J., Lowe, A. S., Walsh, D. M., NicNiocaill, B., Harte, M., OʼConnor, W. T., OʼHara, A. M., Orren, A., Moran, A. P., Hardiman, D. A., Lee, T. C., Croke, D. T., Tolan, R., McBennett, S., Warmington, S., McGuire, M., Bradford, A., OʼHare, T., MacDermott, M., Lynch, F., OʼRegan, R. G., McLoughlin, P., Quinn, T., Ryan, J. P., Pickering, M., Campion, D. P., Jones, J. F. X., Ryan, S., McNicholas, W. T., Nolan, P., Doyle, F. J., Rackard, S. M., Beddy, P., Campbell, V. A., Bakhle, Y. S., Bell, C., Usher, C., Chan, L., Keenan, A. K., McQuaid, K. E., Cullen, V. C., Smith, E. M., Kelly, A., Lynch, M. A., Freir, D. B., Holscher, C., Herron, C. E., Pearson, H. A., Curran, B. P., OʼConnor, J. J., Quinn, A., McHale, J., Moriarty, D., OʼConnor, J., Glennon, J. C., Van Vliet, B. J., Long, S. K., Kruse, C., Gallagher, H. C., Bacon, C. L., Boland, B., Griffin, A. M., Preisler, J., OʼBrien, L., Regan, C. M., Hurley, S., Kearney, P. J., Slevin, J., Barry-Kinsella, C., Ryan, C. A., Kllleen, O., Glllan, J., Clarke, T., Matthews, T., Corcoran, D., Dunn, E., Geary, M., OʼHerlihy, C., Keane, D., OʼLeary, M. J., Morrison, J. J., Ryan, E., Gorman, W. A., Bourke, A., Larkin, J., Mayes, C., Jenkins, J., Ryan, M., Lalchandani, S., Sheil, O., Lynch, N., Costigan, C., Murphy, J. F., Bhatia, R., Foran, A., Donohue, V., McParland, P., LaSjaunais, P., Rodesch, G., McGinn, M., McAloon, J., OʼLeary, M., Astbury, K., Harmon, D., Sharkey, A., Gaffney, G., OʼRegan, G., McMahon, C., Murray, D., McDermott, C., Woolhead, E., Gillan, J., Cartmill, J. L., Harper, M. A., Al-Shabibi, N., Hanahoe, M., Wingfield, M., Larkin, J. A. M., Bell, A. H., McClure, B. G., Sweeney, L., Martin, D. H., OʼDonoghue, P., Davoren, A., Lucas, G. F., McKiernan, J., Gallagher, D. M. T., Dunne, K. P., Fulena, O., Sheridan, M., Griffin, E., White, M., Deasy, P., OʼRiordan, M., OʼGorman, C., Mongan, C., McCafferkey, M., Henry, G., McKenna, P., OʼMalley, A., Devaney, D., Kelleghan, P., Mooney, E. E., Gillan, J. E., Fitzpatrick, M., McQuillan, K., Heffron, C., Hodnett, P., Curtain, A., OʼConnor, T. C. F., Connell, T. G., Waldron, D., Gorman, W., Bolger, T., OʼKeefe, M., Murphy, J., Dolan, L. M., Traub, A. I., Slattery, M. M., Curley, A. E., Halliday, H. L., Tubman, T. R. J., Kileen, O., Riadha, H., Russell, J., Philips, R., Regan, C., Ali, I., Coughlan, A. C. J., Turner, M. J., Smith, A., OʼFlanagan, D., Igoe, D., Ryan, F., Forde, D., McArdle, E., Ko, D., Bedford, D., Hegarty, M., Dunlevy, B., Corcoran, R., Holohan, T., Feeney, A., McGee, H., Shannon, W., Condon, M., Hyland, C., Sayers, G., Feely, E., Crowley, D., OʼReilly, D., OʼConnell, T., Cronin, M., Johnson, H., Fitzgeraldi, M., Cafferkey, M., Breslin, A., Bonner, C. J., Foley, B., Fitzgerald, M., Wall, P. G., McNamara, E., Costigan, P., Prendergast, T., Foye, K., Cosgrove, C., Keane, A., Murphy, E., OʼDonnell, J., Quinlan, A., Thornton, L., Roch, E. A., Lyons, R. A., Maddocks, A., Barnes, P., Price, L., McCabe, M., Nash, P., Midha, A., Doyle, Y., Kilgallen, A., Wright, P., Ryan, T., De La Harpe, D., Harkins, V., Brennan, C., OʼConnell, V., Evans, D. S., Mhuircheartaigh, Ni J., OʼDonnell, J. M., Rhatigan, A., Shelley, E., Collins, C., Byrne, M., Murphy, A. W., Plunkett, P. K., Murray, A., Bury, G., Lynam, F., McMahon, G., Greally, T., Kane, D., Veale, D., Reece, R., Busteed, S., Bennett, M. W., Stone, M., Molloy, C., OʼConnell, J., Molloy, M. G., Shanahan, F., Guerin, J., Casey, E., Feighery, C., Lin, F., Jackson, J., Pendleton, A., Wright, G. D., Hughes, A. E., OʼGradaigh, D., Debham, I., Compston, J., McEvoy, A., Murphy, E. P., Salonen, D., Payne, P., Lax, M., Lapp, V., Inman, R., OʼRourke, K., Brennan, D., Harty, J., McCarthy, C., OʼByrne, J., Eustace, S., Chirayath, H., Liggett, N. W., Morgan, M. P., Fitzgerald, D. J., McCarthy, C. J., McCarthy, G. M., Lee, R. Z., Wai, K., Nevin, D., Leary, A. O., Lee, R., Casey, E. B., OʼLeary, A., Breen, D., Tuite, D., McInerney, D., Sim, R., Frederic, A. L., Smith, O., White, B., Murphy, M., Silke, C., OʼKeeffe, E., Fanning, N., Spence, L., Parfrey, N. A., McConnell, J. R., Crockard, A. D., Cairns, A. P., Bell, A. L., Kavanagh, O., Moyes, D. A., Finch, M., Rooney, M., Bell, A., Founas, I., El-Magbri, A., Mooney, S., Kennedy, M., Coughlan, R. J., Ramakrishnan, S. A., Gsel, A., Finnerty, O., Burns, M., Yateman, M., Camaco-Hubner, C., Matthews, C. F., Taggart, A., Fuller, K., Murphy, M. S., Phelan, M., Murphy, T. B., Wynne, F., Quane, K., Daly, M., OʼLeary, J., da Silva, I., Bermingham, N., Gogarty, M., Gallagher, L. P., OʼHara, R., Godson, C., Brady, H., Osman, H., El-Rafie, A., Foley-Nolan, D., Kirwan, P., Corcoran, O., Duffy, T., Drummond, F., Madigan, A., Williams, D., Gallagher, P., Hatton, C., Cunningham, S., FitzGerald, O., Minnock, P., Wylie, E., Egan, D., Mc Cormack, J., Shea, M. O., Evans, D., OʼLorcain, P., Comber, H., Evans, A., Jones, J., Garavan, C., Kelleher, K., Boland, M. C., Healy, R., OʼSullivan, M. B., Burke, M., Mc Donald, P., Smithson, R., Glass, J., Mason, C. A., Mullins, N., Nolan, D., McCormick, P., Coughlan, S., Dooley, S., Kelleher, C. C., Hope, A., Murphy, F., Barry, M., Sixsmith, J., MacFarlane, A., MacLeod, C., McElroy, G., OʼLoan, D., Kennedy, F., Kerr, R. M., Lim, J., Allwright, S. P. A., Bradley, F. L., Barry, J. M. G., Long, J., Parry, J. V., Creagh, D., Perry, I. J., Collins, A., Neilson, S., Colwell, N., OʼHalloran, D., OʼNeill, S., McErlain, S., Okasha, M., Gaffney, B., McCarron, P., Hinchion, R., Drew, C., Gavin, A., Fitzpatrick, D., Campbell, R., Wannamethee, S. G., Shaper, A., Friel, S., Kelleher, C., Kee, F., Atterson, C. C., Wilson, E. A., McConnell, J. M., Wheeler, S. M., Watson, J. D., Rahman, Norashikin N., Sheehan, J., Wall, C., Kelleher, B., OʼBroin, S. D., Mullan, R. N., McKeveney, P. J., Hodges, V. M., Winter, P. C., Maxwell, P., Simpson, D. A., Lappin, T. R. J., Maxwell, A. P., Eustace, J. A., Coresh, J., Kutchey, C., Te, P. L., Gimenez, L. F., Scheel, P. J., Walser, M., McMahon, R. A., Clarkson, M., Martin, F., Brady, H. R., Blake, C., OʼMeara, Y. M., Gupta, S., MacKenzie, H., Doyle, S., Fotheringham, T., Haslam, P., Logan, M. P., Conlon, P., Lee, M., Maderna, P., Cottell, D. C., Mitchell, S., Gulmann, C., Østerby, R., Bangstad, H. J., Rljdberg, S., Dempsey, M., Nathwani, S., Ryan, M. P., McMahon, B., Stenson, C., Murtagh, H., Brown, J. H., Doran, P., McGinty, A., Little, M. A., OʼBrien, E., Owens, P., Holian, J., Mee, F., Walshe, J. J., Omer, S. A., Power, D., Diamond, P., Watson, R. W., Shahsafei, A., Jiang, T., Brenner, B. M., Mackenzie, H. S., Neary, J., Dorman, A., Keoghan, M., Campbell, E., Walshe, J., Little, M., Nee, L., OʼCeallaigh, C., McGlynn, H., Bergin, E., Keane, T., Gormley, G., Watson, A., Atta, M. G., Perl, T. M., Song, X., Healy, E., Leonard, M., Lynch, J., Watson, A. J., Lappin, D., Lappin, D. W. P., Hannan, K., Burne, M., Daniels, F., Rabb, H., McBride, B., Kieran, N., Shortt, C., Codd, M., Murray, F., McCormack, A., Brown, C., Wong, C., Dorman, A. M., Keogan, M., Donohue, J., Farrell, J., Donohoe, J., OʼBroin, S., Balfe, A., Mellotte, G. J., Abraham, K. A., McGorrian, C., Wood, A. E., Neligan, M., Kelly, B. D., Finnegan, P., Cormican, M., Callaghan, J., Crean, J. K. G., Moffitt, T. A., Devlin, H. L., Garrett, P. J., Soosay, A., OʼNeill, D., Counihan, A., Hickey, D., Keogan, M. T., Harvey, K., OʼRiordan, E., Waldek, S., Kalra, P. A., OʼDonoghue, D. J., Foley, R. N., Kelliher, D., Mellotte, G., Giblin, L., Keogh, J. A. B., OʼConnell, M., OʼMeara, A., Breatnach, F., Gillick, J., Tazawa, H., Puri, P., Molloy, E., OʼNeill, A. J., Sheridan-Pereira, M., Fitzpatrick, J. M., Webb, D. W., Watson, R. W. G., Linnane, B., OʼDonnell, C., Clarke, T. A., Martin, C., McKay, M., McBrien, J., Glynn, F., OʼDonovan, C., Hall, W. W., Smith, J., Khair, K., Liesner, R., Hann, I. M., Smith, O. P., Gallagher, S., Mahony, M. J., Hilal, A., Cosgrove, J. F., Monaghan, C., Craig, B., Walsh, K., Duff, D., Slizlok, P. O., Halahakoon, C., McMillan, S., Dalzell, E. E., McCaughan, J., Redmond, A. O. B., DeCaluwe, D., Yoneda, A., Akl, U., Dempsey, E., Farrell, M., Webb, D., Elabbas, A., Fox, G., Gormally, S., Grant, B., Corkey, C. W. B., Nicholson, A., Murphy, A., OʼGrady, P., Barry, O., Stewart, M. C., Alderdice, F., Matthews, T. G., McDonnell, M., McGarvey, C., OʼRegan, M., Chróinín, Ní M., Tormey, P., Ennis, S., Green, A. J., Abbas, S., OʼMarcaigh, A., Conran, M., Crushell, E., Saidi, A., Curran, P., Donoghue, V., King, M. D., Elnazir, B., Leonard, J., Kavanagh, C., Brown, D., Corrigan, N., McCord, B., Quinn, M., OʼConnell, L., Mcdonagh, B., Awan, A., Gill, D., Kakkar, R., Warner, J. A., OʼConnor, C., Herzig, M., Twomey, A., White, M. J., Sweeney, B., Surana, R., Hodgson, A., Rafferty, M., Livingstone, W., Peake, D., Wassemer, E., Whitehouse, W., Abdullah, N., Al-Hassan, A., Oslizlok, P., OʼConnell, N., Balding, J., Livingstone, W. J., Healy, M., Mynett-Johnson, L., McAllister, I., Dick, A. C., Herron, B., Boston, V. E., Callaghan, C. O., Brien, D. O., Walsh, A., Philip, M., McShane, D., Hoey, M. C. V., Sharif, F., McDermott, M., Dillon, M., Drumm, B., Rowland, M., Imrie, C., Kelleher, S., Bourke, B., Iqbal, M., Ziedan, Y., OʼNeill, M., OʼRiordan, S., Basheer, S. M. B., OʼCallaghan, S., Chong, A., Kelly, M., Nicholson, A. J., Cooke, R., Sreenan, C., Fallon, M., Denham, B., Dowding, V., Cussen, G., McManus, V., Hensey, O., Monaghan, H., Basheer, S. N., Quinn, E., Hoey, H. M. C. V., Mohamed, S., Ramesh, R. R., Mayne, P., Tracy, E., Gormally, S. M., Curtis, E., McCallion, N., Watson, R., OʼMahony, O., Keegan, M., Ward, K., Barton, D., Poulton, J., Treacy, E., Honour, J., deCaluwe, D., Chróinín, Ni M., Cosgrove, J., Chaudhry, T. S., Long, N. M., Lynch, B., Lasjaunais, P., McDonald, D. G. M., McMenamin, J. B., Farrell, M. J., Roche, E. F., Menon, A., Buckley, C., Mackey, A., Ohlandieck, K., Das, A., Reilly, D., Killeen, O., Harper, J., Roche, E., Hoey, H., Caird, J., OʼBrien, D., Allcutt, D., Farrington, N., Murphy, J. F. A., Savage, J. M., Sands, A. J., Casey, F. A., Craig, B. G., Dornan, J. C., Johnston, J., Patterson, C., Lynch, C., Mulholland, H. C., Watkins, D. C., Young, I., Cran, G., Boreham, C. A. G., McCallion, W. A., Clements, N. F., Stevenson, M. R., Macpherson, C., Jenkins, L., Thompson, A. J., Shields, M. D., Taylor, R. T., Kerr, R., Hughes, J. L., Stewart, M., Jackson, P., Fitzpatrick, C., Rasheed, M., Colhoun, E., Bailie, A. G., Gray, S., Brown, S., Curley, A., Sweet, D. G., MacMahon, K. J., OʼConnor, C. M., Nichelson, A., Lynch, N. E., Finch, D., Foley, M., Scallan, E., Dillon, B., Lyons, S., OʼLoughlin, R., Ward, M., Nally, R., Harkin, A., Kelly, J. P., Leonard, B. E., Magee, P., Connor, T. J., Shen, Y., McCullough, G. R., McDonough, S. M., Niocaill, Nic B., Cramp, A. F. L., Hynes, M., Corkery, P., Carey, M., McGarrigle, D., Higgins, S., Murray, H., Moran, C. J., Dennedy, M. C., Brosnan, J., Morris, L., Sheppard, B. L., Black, A., Wilkins, B., Folan-Curran, J., Skelton, K., Owens, M., Nemeroff, C., Houlihan, D., OʼKeeffe, C., Nolan, N., McCormick, P. A., Baird, A. W., Raducan, I., Corcoran, P., Brennan, R., Molloy, P., Friel, A., Maher, M., Glennon, M., Smith, T., Nolan, A., Houghton, J. A., Carroll, O., Colleran, S., OʼCuinn, G., Snow, H. M., OʼRegan, D., Markos, H. F., Pollock, K., Cannon, D. M., McBean, G., OʼRiordan, A., Quinlan, L. R., Kane, M. T., Higglns, B. D., Moriarty, D. M., Fitzgerald, D., Katkada, A., Canny, G., MacMathuna, P., OʼDonoghue, D., OʼDonovan, M. M., Schuur, A. G., Murphy, K. J., Foley, A. G., ten Bruggencate, S. J. M., and Ireland, L.

Published
2000
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34. Treatment with 6 Cycles of CVP or R-CVP after Involved Field Radiation Therapy (IFRT) Significantly Improves Progression-free Survival Compared to IFRT alone in Stage I-II Low Grade Follicular Lymphoma: Results of an International Randomized Trial

Author

MacManus, M.P., primary, Fisher, R., additional, Roos, D., additional, O'Brien, P., additional, Macann, A.M.J., additional, Christie, D., additional, Tsang, R.W., additional, Davis, S.R., additional, Joseph, D.J., additional, McClure, B., additional, and Seymour, J., additional

Published
2016
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35. Towards characterization of photo-excited electron transfer and catalysis in natural and artificial systems using XFELs

Author

Alonso-Mori, R., Asa, K., Bergmann, U., Brewster, A. S., Chatterjee, R., Cooper, J. K., Frei, H. M., Fuller, F. D., Goggins, E., Gul, S., Fukuzawa, H., Iablonskyi, D., Ibrahim, M., Katayama, T., Kroll, T., Kumagai, Y., McClure, B. A., Messinger, Johannes, Motomura, K., Nagaya, K., Nishiyama, T., Saracini, C., Sato, Y., Sauter, N. K., Sokaras, D., Takanashi, T., Togashi, T., Ueda, K., Weare, W. W., Weng, T-C, Yabashi, M., Yachandra, V. K., Young, I. D., Zouni, A., Kern, J. F., Yano, J., Alonso-Mori, R., Asa, K., Bergmann, U., Brewster, A. S., Chatterjee, R., Cooper, J. K., Frei, H. M., Fuller, F. D., Goggins, E., Gul, S., Fukuzawa, H., Iablonskyi, D., Ibrahim, M., Katayama, T., Kroll, T., Kumagai, Y., McClure, B. A., Messinger, Johannes, Motomura, K., Nagaya, K., Nishiyama, T., Saracini, C., Sato, Y., Sauter, N. K., Sokaras, D., Takanashi, T., Togashi, T., Ueda, K., Weare, W. W., Weng, T-C, Yabashi, M., Yachandra, V. K., Young, I. D., Zouni, A., Kern, J. F., and Yano, J.

Abstract

The ultra-bright femtosecond X-ray pulses provided by X-ray Free Electron Lasers (XFELs) open capabilities for studying the structure and dynamics of a wide variety of biological and inorganic systems beyond what is possible at synchrotron sources. Although the structure and chemistry at the catalytic sites have been studied intensively in both biological and inorganic systems, a full understanding of the atomic-scale chemistry requires new approaches beyond the steady state X-ray crystallography and X-ray spectroscopy at cryogenic temperatures. Following the dynamic changes in the geometric and electronic structure at ambient conditions, while overcoming X-ray damage to the redox active catalytic center, is key for deriving reaction mechanisms. Such studies become possible by using the intense and ultra-short femtosecond X-ray pulses from an XFEL, where sample is probed before it is damaged. We have developed methodology for simultaneously collecting X-ray diffraction data and X-ray emission spectra, using an energy dispersive spectrometer, at ambient conditions, and used this approach to study the room temperature structure and intermediate states of the photosynthetic water oxidizing metallo-protein, photosystem II. Moreover, we have also used this setup to simultaneously collect the X-ray emission spectra from multiple metals to follow the ultrafast dynamics of light-induced charge transfer between multiple metal sites. A Mn-Ti containing system was studied at an XFEL to demonstrate the efficacy and potential of this method.

Published
2016
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38. Towards characterization of photo-excited electron transfer and catalysis in natural and artificial systems using XFELs

Author

Alonso-Mori, R., primary, Asa, K., additional, Bergmann, U., additional, Brewster, A. S., additional, Chatterjee, R., additional, Cooper, J. K., additional, Frei, H. M., additional, Fuller, F. D., additional, Goggins, E., additional, Gul, S., additional, Fukuzawa, H., additional, Iablonskyi, D., additional, Ibrahim, M., additional, Katayama, T., additional, Kroll, T., additional, Kumagai, Y., additional, McClure, B. A., additional, Messinger, J., additional, Motomura, K., additional, Nagaya, K., additional, Nishiyama, T., additional, Saracini, C., additional, Sato, Y., additional, Sauter, N. K., additional, Sokaras, D., additional, Takanashi, T., additional, Togashi, T., additional, Ueda, K., additional, Weare, W. W., additional, Weng, T.-C., additional, Yabashi, M., additional, Yachandra, V. K., additional, Young, I. D., additional, Zouni, A., additional, Kern, J. F., additional, and Yano, J., additional

Published
2016
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39. Proceedings of the 13th annual clinical meeting of the irish perinatal society, held in drogheda in march 1985

Author

Stuart, Bernard, Fox, Declan, Murphy, Harry, Lynch, Bryan, Loftus, J., Naughten, E., Saul, I., Sheil, O., Duignan, N., Jackson, A., Gorman, W. A., Fox, G., Matthews, T., Clarke, T., Reid, Mark M., Halliday, H. L., McClure, B. G., Thomas, P. S., O’Dowd, Michael, O’Dowd, Michael J., Connolly, Kevin, Leahy, F., White, R. G., Connolly, Ruth, O’Herlihy, Colm, and Radic, Alicja

Published
1986
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40. Irish neurological association: Meeting, Belfast, May 20th/21st, 1983

Author

McCormick, Derek, Wallace, Ian, Thompson, A., Hutchinson, M., Hawkins, S. A., Connolly, J. H., Lyttle, J. A., Montgomery, E. A., McClelland, R. J., Houston, G., Fenton, G. W., Millar, Harold, Martin, E. A., Galway, J. E., Sawhney, B. B., Forsythe, Ian, Sills, Mike, Callaghan, N., Kenny, Rose Anne, O’Neill, B., Crowley, M., Goggin, T., McDonald, Kenneth, Bresnihan, Barry, Behan, Wilhemina M. H., Behan, Peter O., O’Laoire, Sean, Hutchinson, Ros, Nevin, Norman C., Finucane, Paul, Murphy, Sean F., Morrow, James, McDowell, Helen, Ritchie, Catherine, Patterson, Victor, Brown, D. A., McClure, B. G., Lawless, V., and O’Donnell, L.

Published
1984
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41. Irish perinatal society Proceedings of the Annual General Meeting, March 31st, 1984.

Author

Reid, M., Halliday, H. L., McClure, B. G., Egan, Declan, O’Herlihy, Colm, Dockeray, C. J., Gleeson, R. P., Powell, B. F. M., Hanratty, T. D., Keane, Anne, Connolly, John, MacCarthy, Paul, O’Connell, Pauline, Bowman, Paul, Gray, Peter H., Derham, R., Matthews, T. G., Clarke, T. A., Boylan, P., O’Donovan, P., Owens, O. J., Fitsimons, R., Keohane, K., Galvin, J., Clinch, J. A. D., Gillen, J. E., Nicholson, A., Bowell, R., Gorman, W., Erskine, R. L. A., and Ritchie, J. W. K.

Published
1984
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42. Inhibition of matrix metalloproteinase-2 improves endothelial function and prevents hypertension in insulin-resistant rats

Author

Nagareddy, PR, Rajput, PS, Vasudevan, H, McClure, B, Kumar, U, MacLeod, KM, and McNeill, JH

Subjects
Male, Nitric Oxide Synthase Type III, Endothelial Cells, Aorta, Thoracic, Fructose, Matrix Metalloproteinase Inhibitors, Nitric Oxide, Research Papers, Mesenteric Arteries, Rats, Doxycycline, Hypertension, Animals, Matrix Metalloproteinase 2, Cattle, Endothelium, Vascular, HSP90 Heat-Shock Proteins, Insulin Resistance, Rats, Wistar, Cells, Cultured
Abstract

Insulin resistance is often found to be associated with high blood pressure. We propose that in insulin-resistant hypertension, endothelial dysfunction is the consequence of increased activity of vascular MMP-2. As MMP-2 proteolytically cleaves a number of extracellular matrix proteins, we hypothesized that MMP-2 impairs endothelial function by proteolytic degradation of endothelial NOS (eNOS) or its cofactor, heat shock protein 90 (HSP90).We tested our hypothesis in bovine coronary artery endothelial cells and fructose-fed hypertensive rats (FHR), a model of acquired systolic hypertension and insulin resistance.Treatment of FHRs with the MMP inhibitor doxycycline, preserved endothelial function as well as prevented the development of hypertension, suggesting that MMPs impair endothelial function. Furthermore, incubating endothelial cells in vitro with a recombinant MMP-2 decreased NO production in a dose-dependent manner. Using substrate cleavage assays and immunofluorescence microscopy studies, we found that MMP-2 not only cleaves and degrades HSP90, an eNOS cofactor but also co-localizes with both eNOS and HSP90 in endothelial cells, suggesting that MMPs functionally interact with the eNOS system. Treatment of FHRs with doxycycline attenuated the decrease in eNOS and HSP90 expression but did not improve insulin sensitivity.Our data suggest that increased activity of MMP-2 in FHRs impairs endothelial function and promotes hypertension. Inhibition of MMP-2 could be a potential therapeutic strategy for the management of hypertension.

Published
2012

43. A phase II trial of integrated preoperative radiotherapy and chemotherapy with oxaliplatin 5-fluorouracil and folinic acid in patients with locally advanced rectal cancer: Trans-tasman radiation oncology group trog 09.01.

Author

Kumar M., Strickland A., Michael M., Leong T., Heriot A., Ngan S., Bressel M., McClure B., Chander S., McKendrick J., Steel M., Mackay J., Cooray P., Kumar M., Strickland A., Michael M., Leong T., Heriot A., Ngan S., Bressel M., McClure B., Chander S., McKendrick J., Steel M., Mackay J., and Cooray P.

Abstract

Purpose/Objective(s): The 5-fluorouracil (5-FU) chemotherapy dose used during chemoradiation for locally advanced rectal cancer is adequate for radiosensitization but suboptimal for possible micrometastatic disease. The aim of this study was to determine the tolerability rate, dose intensity, complete pathologic response rate, and toxicity rates of a novel preoperative regimen of split-course chemoradiation with interdigitating chemotherapy in the setting of a multi-center study. This trial was performed under the auspices of the Trans-Tasman Radiation Oncology Group. Materials/Methods: Eligible patients for this study were those with MRIstaged T3-4 Nany M0 adenocarcinoma of the rectum. The preoperative treatment regimen consisted of FOLFOX chemotherapy (oxaliplatin 100 mg/m2 day 1, 5-FU 400 mg/m2 bolus day 1, leucovorin 200 mg/m2 day 1, then continuous infusion 2.4 g/m2 over 46 hours) given in week 1, 6, and 11 with split-course pelvic radiotherapy (25.2 Gy in 3 weeks in 1.8 Gy/fx with concurrent oxaliplatin 85 mg/m2 day 1, and 5-FU continuous infusion 200 mg/m2/day) given in week 3-5, and week 8-10. Surgery was to be performed 4 to 6 weeks later. In total, patients received, in 11 weeks, 3 courses of FOLFOX and pelvic radiation 50.4 Gy with concurrent oxaliplatin and 5-FU. Result(s): Forty-one patients were recruited with 40 analyzable patients. The median age was 61.5 (range 29-77) years. Seventy-two percent were men. MRI-stage of the rectal primary was T3 88% and T4 12%. N-stage was N0 20%, N1 52%, N2 28%. Thirty-eight patients (95%) reached week eleven of the treatment (80% CI = [87% - 99%]). All patients received the planned radiation dose of 50.4 Gy. Relative dose intensity of >= 75% was achieved by 92% and 98% of patients for oxaliplatin and 5-FU respectively. During the preoperative protocol therapy period, grade 3 toxicity included neutropenia 25%, diarrhea 10%, ALT 10%, fatigue 5%, proctitis 5%, and urinary frequency 5%. All grade 4 toxicities were neutro

Published
2014

44. Phase II trial evaluating the feasibility of interdigitating folfox with chemoradiotherapy in locally advanced and metastatic rectal cancer

Author

Michael, M, Chander, S, McKendrick, J, MacKay, JR, Steel, M, Hicks, R, Heriot, A, Leong, T, Cooray, P, Jefford, M, Zalcberg, J, Bressel, M, McClure, B, Ngan, SY, Michael, M, Chander, S, McKendrick, J, MacKay, JR, Steel, M, Hicks, R, Heriot, A, Leong, T, Cooray, P, Jefford, M, Zalcberg, J, Bressel, M, McClure, B, and Ngan, SY

Abstract

BACKGROUND: Patients (pts) with metastatic rectal cancer and symptomatic primary, require local and systemic control. Chemotherapy used during chemoradiotherapy (CRT) is adequate for radiosensitisation, but suboptimal for systemic control. The aim of this phase II study was to assess tolerability, local/systemic benefits, of a novel regimen delivering interdigitating intensive chemotherapy with radical CRT. METHODS: Eligible pts had untreated synchronous symptomatic primary/metastatic rectal cancer. A total of 12 weeks of treatment with split-course pelvic CRT (total 50.4 Gy with concurrent oxaliplatin and 5-FU infusion) alternating with FOLFOX chemotherapy. All pts staged with CT, MRI and FDG-PET pre and post treatment. RESULTS: Twenty-six pts were treated. Rectal primary MRI stage: T3 81% and T4 15%. Liver metastases in 81%. Twenty-four pts (92%) completed the 12-week regimen. All patients received planned RT dose, and for both agents over 88% of patients achieved a relative dose intensity of >75%. Grade 3 toxicities: neutropenia 23%, diarrhoea 15%, and radiation skin reaction 12%. Grade 4 toxicity: neutropenia 15%. FDG-PET metabolic response rate for rectal primary 96%, and for metastatic disease 60%. CONCLUSIONS: Delivery of interdigitating chemotherapy with radical CRT was feasible to treat both primary and metastatic rectal cancer. High completion and response rates were encouraging.

Published
2014

47. The impact of various cycling regimens on phosphorus removal in chronic peritoneal dialysis patients

Author

McClure B, Alan S. Kliger, Eras J, Fredric O. Finkelstein, and Peter H. Juergensen

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, 030232 urology & nephrology, Biomedical Engineering, Urology, Medicine (miscellaneous), Renal function, chemistry.chemical_element, Bioengineering, Peritoneal dialysis, Biomaterials, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Peritoneal Dialysis, Continuous Ambulatory, Dialysis Solutions, medicine, Humans, 030212 general & internal medicine, Dialysis, Creatinine, Kidney, business.industry, Phosphorus, Liter, General Medicine, Middle Aged, Phosphate, Surgery, medicine.anatomical_structure, chemistry, Female, business
Abstract

Background The National Kidney Foundation Dialysis Outcome Quality Initiative clinical practice guidelines have suggested that serum phosphate levels be maintained at ≤ 5.5 mg/dL in patients maintained on dialysis. Over 45% of anuric patients maintained on CAPD have serum phosphate levels > 5.5 mg/dL. The present study was designed to address the question whether phosphate removal could be enhanced by increasing the dialysate volume during cycler peritoneal dialysis therapy. Methods Medically stable patients maintained on chronic peritoneal dialysis therapy, who were high or high-average transporters and had serum phosphate levels ≥ 5.5 mg/dL, were invited to participate in the study. The protocol involved measuring phosphate and creatinine clearances at weekly intervals on three different cycler prescriptions consisting of 7 and 12 full cycles or 24 cycles with 50% tidal PD (TPD) over 9 hours. Ten patients agreed to participate. Those patients (n=7) with a BMI > 22 had 2 liter (L) fill volumes and 14 L of total dialysate (7 cycles of 2 L) or 24 L total dialysate (12 cycles of 2 L or 50% TPD with 24 cycles). The patients (n=3) with a BMI & 20 had 1.2 L fill volumes and 8.4 L total dialysate (7 cycles) or 14.4 L total dialysate (12 cycles of 1.2 L or 50% TPD with 24 cycles). Results The mean age (± SD) of the study patients was 50.8 (± 9.3) years. There were 6 females, 6 Caucasians and 4 African-Americans. The mean weight of the patients was 71.5 (± 24.2) kg and mean height 1.65 (+ 7.6) meters. The mean BMI was 18.3 (± 1.27) in the < 20 BMI group and 30.3 (± 6.6) in the > 22 BMI group. The mean phosphate clearance (L/night/1.73m2) increased from 3.96 (± 1.16) with 7 cycles to 4.71 (+ 1.81) with 12 cycles and 4.51 (± 1.61) with 50% TPD. Creatinine clearance (L/night/1.73m2) was 4.74 (± 1.74) with 7 cycles, 6.06 (± 2.04) with 12 cycles and 5.61 (± 2.01) with TPD. Conclusion The present study indicates that there is a significant, 19% (P & 0.005) rise in phosphate clearance by increasing dialysate volume 71% from 7 cycles to 14 cycles compared to a 27% increase in creatinine clearance. With tidal PD, phosphate clearance increased by 12% (p=NS) and creatinine clearance increased 18 % (p, 0.02). This increase in phosphate clearance translates into & 50 mg net phosphate removal in 9 hours, assuming a serum phosphate of 6 mg/%. Thus, increasing dialysis cycles and volume results in only a minimal increase in net phosphate removal.

Published
2006

48. Irish Perinatal Society 14th Annual General Meeting, Belfast, March, 1986

Author

Morrow, R. J., Harper, M. A., McShane, M. A., Maguire, S., Halliday, H. L., McClure, B. G., McReid, M., Murphy, J., Eldridge, P., Varma, T., Haywood, T., Grant, J., McCord, F. B., Bowe, P., Shershah, G., McGuinness, F. P. J., Dowding, V. H., Duignan, N. M., Henry, G. R., MacDonald, D. W., Thomas, P. S., Lupton, B., Sykes, D. H., Bill, J. M., Hoy, E. A., Graeme-Cook, F., Taylor, R., Gillen, J. E., Meehan, F. P., Burke, G., Sheil, J., O’Riordan, M., Nicholson, A., O’Brien, N., Gorman, W. A., Shields, M. D., Davies, E. A., Brett, F., Keohane, C., McMullan, P. F., Curtain, A., Cussen, G., and Crowley, P.

Published
1988
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50. Phase II trial evaluating the feasibility of interdigitating folfox with chemoradiotherapy in locally advanced and metastatic rectal cancer

Author

Michael, M, primary, Chander, S, additional, McKendrick, J, additional, MacKay, J R, additional, Steel, M, additional, Hicks, R, additional, Heriot, A, additional, Leong, T, additional, Cooray, P, additional, Jefford, M, additional, Zalcberg, J, additional, Bressel, M, additional, McClure, B, additional, and Ngan, S Y, additional

Published
2014
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