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2. Racial, Ethnic, Sex, and Age Differences in COVID-19 Cases, Hospitalizations, and Deaths Among Incarcerated People and Staff in Correctional Facilities in Six Jurisdictions, United States, March-July 2020

Author

D’Inverno, Ashley S., Myles, Ranell L., Jamison, Calla R., Williams, Samantha P., Hagan, Liesl M., Handanagic, Senad, Lambert, Lauren A., Clarke, Kristie E. N., Allen, Jeffery, Beard, Olivia, Dusseau, Charles, Feldman, Rachel, Huebsch, Rebecca, Hutchinson, Justine, Kall, Denise, King-Mohr, Jessica, Long, Michael, McClure, Elizabeth S., Meddaugh, Paul, Pontones, Pam, Rose, Jacqueline, Sredl, Megan, VonBank, Brittany, and Zipprich, Jennifer

Published
2024
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3. Diagnostic accuracy of ASQ for screening of neurodevelopmental delays in low resource countries.

Author

Manasyan, Albert, Salas, Ariel, Nolen, Tracy, Chomba, Elwyn, Mazariegos, Manolo, Tshefu Kitoto, Antoinette, Saleem, Sarah, Naqvi, Farnaz, Hambidge, K, Goco, Norman, McClure, Elizabeth, Biasini, Fred, Goldenberg, Robert, Bose, Carl, Koso-Thomas, Marion, Krebs, Nancy, Carlo, Waldemar, and Wallander, Jan

Subjects
community child health, developmental neurology & neurodisability, paediatric neurology, Child, Infant, Humans, Child, Preschool, Communication, Guatemala, Health Personnel, Income, Neurodevelopmental Disorders
Abstract

OBJECTIVE: The Bayley Scales of Infant Development (BSID) is the most used diagnostic tool to identify neurodevelopmental disorders in children under age 3 but is challenging to use in low-resource countries. The Ages and Stages Questionnaire (ASQ) is an easy-to-use, low-cost clinical tool completed by parents/caregivers that screens children for developmental delay. The objective was to determine the performance of ASQ as a screening tool for neurodevelopmental impairment when compared with BSID second edition (BSID-II) for the diagnosis of moderate-to-severe neurodevelopmental impairment among infants at 12 and 18 months of age in low-resource countries. METHODS: Study participants were recruited as part of the First Bites Complementary Feeding trial from the Democratic Republic of Congo, Zambia, Guatemala and Pakistan between October 2008 and January 2011. Study participants underwent neurodevelopmental assessment by trained personnel using the ASQ and BSID-II at 12 and 18 months of age. RESULTS: Data on both ASQ and BSID-II assessments of 1034 infants were analysed. Four of five ASQ domains had specificities greater than 90% for severe neurodevelopmental delay at 18 months of age. Sensitivities ranged from 23% to 62%. The correlations between ASQ communications subscale and BSID-II Mental Development Index (MDI) (r=0.38) and between ASQ gross motor subscale and BSID-II Psychomotor Development Index (PDI) (r=0.33) were the strongest correlations found. CONCLUSION: At 18 months, ASQ had high specificity but moderate-to-low sensitivity for BSID-II MDI and/or PDI

Published
2023

4. Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis

Author

Smith, Emily R, Oakley, Erin, Grandner, Gargi Wable, Ferguson, Kacey, Farooq, Fouzia, Afshar, Yalda, Ahlberg, Mia, Ahmadzia, Homa, Akelo, Victor, Aldrovandi, Grace, Barr, Beth A Tippett, Bevilacqua, Elisa, Brandt, Justin S, Broutet, Nathalie, Buhigas, Irene Fernández, Carrillo, Jorge, Clifton, Rebecca, Conry, Jeanne, Cosmi, Erich, Crispi, Fatima, Crovetto, Francesca, Delgado-López, Camille, Divakar, Hema, Driscoll, Amanda J, Favre, Guillaume, Flaherman, Valerie J, Gale, Chris, Gil, Maria M, Gottlieb, Sami L, Gratacós, Eduard, Hernandez, Olivia, Jones, Stephanie, Kalafat, Erkan, Khagayi, Sammy, Knight, Marian, Kotloff, Karen, Lanzone, Antonio, Le Doare, Kirsty, Lees, Christoph, Litman, Ethan, Lokken, Erica M, Longo, Valentina Laurita, Madhi, Shabir A, Magee, Laura A, Martinez-Portilla, Raigam Jafet, McClure, Elizabeth M, Metz, Tori D, Miller, Emily S, Money, Deborah, Moungmaithong, Sakita, Mullins, Edward, Nachega, Jean B, Nunes, Marta C, Onyango, Dickens, Panchaud, Alice, Poon, Liona C, Raiten, Daniel, Regan, Lesley, Rukundo, Gordon, Sahota, Daljit, Sakowicz, Allie, Sanin-Blair, Jose, Söderling, Jonas, Stephansson, Olof, Temmerman, Marleen, Thorson, Anna, Tolosa, Jorge E, Townson, Julia, Valencia-Prado, Miguel, Visentin, Silvia, von Dadelszen, Peter, Waldorf, Kristina Adams, Whitehead, Clare, Yassa, Murat, Tielsch, Jim M, Langenegger, Eduard, Sam-Agudu, Nadia A, Gachuno, Onesmus W, Sekikubo, Musa, Mukwege, Denis M, Omore, Richard, Ouma, Gregory, Onyango, Clayton, Otieno, Kephas, Were, Zacchaeus Abaja, Were, Joyce, İlter, Pinar Birol, Mboizi, Robert, Hookham, Lauren, Meli, Federica, Bonanni, Giulia, Romanzi, Federica, Torcia, Eleonora, di Ilio, Chiara, Ananth, Cande V, Hill, Jennifer, Reddy, Ajay, Patrick, Haylea Sweat, Baba, Vuyelwa, and Adam, Mary

Subjects
Biodefense, Pneumonia, Lung, Infant Mortality, Vaccine Related, Emerging Infectious Diseases, Clinical Trials and Supportive Activities, Clinical Research, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Preterm, Low Birth Weight and Health of the Newborn, Infectious Diseases, Prevention, Pneumonia & Influenza, Infection, Reproductive health and childbirth, Good Health and Well Being, Infant, Newborn, Pregnancy, Female, Humans, Pregnant Women, Prospective Studies, COVID-19, SARS-CoV-2, Maternal health, Epidemiology, Perinatal COVID PMA Study Collaborators
Abstract

IntroductionDespite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies.MethodsWe screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute and relative risk (RR) of adverse outcomes among pregnant women with SARS-CoV-2 infection, compared with confirmed negative pregnancies. We evaluated the risk of bias using a modified Newcastle-Ottawa Scale.ResultsWe screened 137 studies and included 12 studies in 12 countries involving 13 136 pregnant women.Pregnant women with SARS-CoV-2 infection-as compared with uninfected pregnant women-were at significantly increased risk of maternal mortality (10 studies; n=1490; RR 7.68, 95% CI 1.70 to 34.61); admission to intensive care unit (8 studies; n=6660; RR 3.81, 95% CI 2.03 to 7.17); receiving mechanical ventilation (7 studies; n=4887; RR 15.23, 95% CI 4.32 to 53.71); receiving any critical care (7 studies; n=4735; RR 5.48, 95% CI 2.57 to 11.72); and being diagnosed with pneumonia (6 studies; n=4573; RR 23.46, 95% CI 3.03 to 181.39) and thromboembolic disease (8 studies; n=5146; RR 5.50, 95% CI 1.12 to 27.12).Neonates born to women with SARS-CoV-2 infection were more likely to be admitted to a neonatal care unit after birth (7 studies; n=7637; RR 1.86, 95% CI 1.12 to 3.08); be born preterm (7 studies; n=6233; RR 1.71, 95% CI 1.28 to 2.29) or moderately preterm (7 studies; n=6071; RR 2.92, 95% CI 1.88 to 4.54); and to be born low birth weight (12 studies; n=11 930; RR 1.19, 95% CI 1.02 to 1.40). Infection was not linked to stillbirth. Studies were generally at low or moderate risk of bias.ConclusionsThis analysis indicates that SARS-CoV-2 infection at any time during pregnancy increases the risk of maternal death, severe maternal morbidities and neonatal morbidity, but not stillbirth or intrauterine growth restriction. As more data become available, we will update these findings per the published protocol.

Published
2023

5. Zinc Supplementation Initiated Prior to or During Pregnancy Modestly Impacted Maternal Status and High Prevalence of Hypozincemia in Pregnancy and Lactation: The Women First Preconception Maternal Nutrition Trial

Author

Dhaded, Sangappa M, Vernekar, Sunil S, Herekar, Veena R, Yogeshkumar, S, McClure, Elizabeth M, Das, Abhik, Thorsten, Vanessa R, Derman, Richard J, Goldenberg, Robert L, Koso-Thomas, Marion W, Kemp, Jennifer F, Hambidge, K Michael, Westcott, Jamie L, Ali, Sumera Aziz, Saleem, Sarah, Garcés, Ana, Figueroa, Lester, Somannavar, Manjunath S, Goudar, Shivaprasad S, Long, Julie M, Hendricks, Audrey E, and Krebs, Nancy F

Published
2024
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6. The Impact of Excluding Adverse Neonatal Outcomes on the Creation of Gestational Weight Gain Charts Among Women from Low- and Middle-income Countries with Normal and Overweight BMI

Author

Accrombessi, Manfred, Adu-Afarwuah, Seth, Alves, João Guilherme, Leal de Araújo, Carla Adriane, Arifeen, Shams, Artes, Rinaldo, Ashorn, Per, Ashorn, Ulla, Assefa, Nega, Ayoola, Omolola Olukemi, Azizi, Fereidoun, Bawah, Ahmed Tijani, Behboudi-Gandevani, Samira, Berhane, Yemane, Bernstein, Robin, Bhutta, Zulfiqar, Briand, Valérie, Calvo, Elvira Beatriz, Cardoso, Marly Augusto, Cheng, Yue, Chico-Barba, Gabriela, Clayton, Peter Ellis, Collins, Shalean M, Costello, Anthony M, Cruickshank, John Kennedy, Devakumar, Delanjathan, Dewey, Kathryn G, Dwarkanath, Pratibha, Estrada-Gutierrez, Guadalupe, Fair, Frankie J, Farias, Dayana Rodrigues, Friis, Henrik, Ghosh, Shibani, Girard, Amy Webb, Gomo, Exnevia, Gondwe, Austrida, Hallamaa, Lotta, Hambidge, K Michael, Hussein, Hawawu, Huybregts, Lieven, Iqbal, Romaina, Katz, Joanne, Khatry, Subarna K, Kolsteren, Patrick, Krebs, Nancy F, Kulmala, Teija, Kumar, Pratap, Kurpad, Anura V, Lachat, Carl, Lartey, Anna, Lauer, Jacqueline M, Li, Qian, Lipoeto, Nur Indrawaty, López, Laura Beatriz, Loy, See Ling, Maiya, G Arun, Maleta, Kenneth, Malta, Maíra Barreto, Manandhar, Dharma S, Mangani, Charles, Martínez-Rojano, Hugo, Martin-Prevel, Yves, Martorell, Reynaldo, Matias, Susana L, McClure, Elizabeth M, Melse-Boonstra, Alida, Miller, Joshua D, Mohamad, Marhazlina, Jan Mohamed, Hamid Jan, Moore, Sophie, Mosquera, Paola Soledad, Mridha, Malay Kanti, Munim, Shama, Muñoz-Manrique, Cinthya, Natamba, Barnabas K, Ome-Kaius, Maria, Osrin, David, Perichart-Perera, Otilia, Prentice, Andrew M, Ramachandra, Preetha, Ramakrishnan, Usha, Rivera, Juan, Roberfroid, Dominique, Rodrigues, Patricia Lima, Rodríguez-Cano, Ameyalli, Rogerson, Stephen J, Rondó, Patricia HC, Sámano, Reyna, Saville, Naomi M, Shivalli, Siddharudha, Shrestha, Bhim P, Shrestha, Robin, Roberto da Silva Júnior, José, Soltani, Hora, Soofi, Sajid, Tehrani, Fahimeh Ramezani, Thomas, Tinku, Tielsch, James M, Unger, Holger W, Vaz, Juliana dos Santos, Worku, Alemayehu, Yang, Nianhong, Young, Sera L, Yussif, Adam Bawa, Zeng, Lingxia, Zhong, Chunrong, Zhu, Zhonghai, Rangel Bousquet Carrilho, Thais, Wang, Dongqing, Hutcheon, Jennifer A, Wang, Molin, Fawzi, Wafaie W, and Kac, Gilberto

Published
2024
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7. Maternal and perinatal outcomes of women with vaginal birth after cesarean section compared to repeat cesarean birth in select South Asian and Latin American settings of the global network for women’s and children’s health research

Author

Figueroa, Lester, Harrison, Margo, Mazariegos, Manolo, Goudar, Shivaprasad, Kavi, Avinash, Derman, Richard, Patel, Archana, Das, Prabir, Hibberd, Patricia L., Saleem, Sarah, Naqvi, Farnaz, Goldenberg, Robert L., Haque, Rashidul, Billah, Sk Masum, Petri, Jr., William A., McClure, Elizabeth M., Tan, Sylvia, and Krebs, Nancy F.

Published
2023
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8. Building a predictive model of low birth weight in low- and middle-income countries: a prospective cohort study

Author

Patterson, Jackie K., Thorsten, Vanessa R., Eggleston, Barry, Nolen, Tracy, Lokangaka, Adrien, Tshefu, Antoinette, Goudar, Shivaprasad S., Derman, Richard J., Chomba, Elwyn, Carlo, Waldemar A., Mazariegos, Manolo, Krebs, Nancy F., Saleem, Sarah, Goldenberg, Robert L., Patel, Archana, Hibberd, Patricia L., Esamai, Fabian, Liechty, Edward A., Haque, Rashidul, Petri, Bill, Koso-Thomas, Marion, McClure, Elizabeth M., Bose, Carl L., and Bauserman, Melissa

Published
2023
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9. Protocol for a sequential, prospective meta-analysis to describe coronavirus disease 2019 (COVID-19) in the pregnancy and postpartum periods

Author

Smith, Emily R, Oakley, Erin, He, Siran, Zavala, Rebecca, Ferguson, Kacey, Miller, Lior, Grandner, Gargi Wable, Abejirinde, Ibukun-Oluwa Omolade, Afshar, Yalda, Ahmadzia, Homa, Aldrovandi, Grace, Akelo, Victor, Barr, Beth A Tippett, Bevilacqua, Elisa, Brandt, Justin S, Broutet, Natalie, Buhigas, Irene Fernández, Carrillo, Jorge, Clifton, Rebecca, Conry, Jeanne, Cosmi, Erich, Delgado-López, Camille, Divakar, Hema, Driscoll, Amanda J, Favre, Guillaume, Flaherman, Valerie, Gale, Christopher, Gil, Maria M, Godwin, Christine, Gottlieb, Sami, Bellolio, Olivia Hernandez, Kara, Edna, Khagayi, Sammy, Kim, Caron Rahn, Knight, Marian, Kotloff, Karen, Lanzone, Antonio, Le Doare, Kirsty, Lees, Christoph, Litman, Ethan, Lokken, Erica M, Longo, Valentina Laurita, Magee, Laura A, Martinez-Portilla, Raigam Jafet, McClure, Elizabeth, Metz, Torri D, Money, Deborah, Mullins, Edward, Nachega, Jean B, Panchaud, Alice, Playle, Rebecca, Poon, Liona C, Raiten, Daniel, Regan, Lesley, Rukundo, Gordon, Sanin-Blair, Jose, Temmerman, Marleen, Thorson, Anna, Thwin, Soe, Tolosa, Jorge E, Townson, Julia, Valencia-Prado, Miguel, Visentin, Silvia, von Dadelszen, Peter, Waldorf, Kristina Adams, Whitehead, Clare, Yang, Huixia, Thorlund, Kristian, and Tielsch, James M

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Health Sciences, Clinical Research, Emerging Infectious Diseases, Pediatric, Prevention, Reproductive health and childbirth, Good Health and Well Being, Adolescent, COVID-19, Child, Female, Humans, Infant, Newborn, Meta-Analysis as Topic, Postpartum Period, Pregnancy, Prospective Studies, Retrospective Studies, SARS-CoV-2, General Science & Technology
Abstract

We urgently need answers to basic epidemiological questions regarding SARS-CoV-2 infection in pregnant and postpartum women and its effect on their newborns. While many national registries, health facilities, and research groups are collecting relevant data, we need a collaborative and methodologically rigorous approach to better combine these data and address knowledge gaps, especially those related to rare outcomes. We propose that using a sequential, prospective meta-analysis (PMA) is the best approach to generate data for policy- and practice-oriented guidelines. As the pandemic evolves, additional studies identified retrospectively by the steering committee or through living systematic reviews will be invited to participate in this PMA. Investigators can contribute to the PMA by either submitting individual patient data or running standardized code to generate aggregate data estimates. For the primary analysis, we will pool data using two-stage meta-analysis methods. The meta-analyses will be updated as additional data accrue in each contributing study and as additional studies meet study-specific time or data accrual thresholds for sharing. At the time of publication, investigators of 25 studies, including more than 76,000 pregnancies, in 41 countries had agreed to share data for this analysis. Among the included studies, 12 have a contemporaneous comparison group of pregnancies without COVID-19, and four studies include a comparison group of non-pregnant women of reproductive age with COVID-19. Protocols and updates will be maintained publicly. Results will be shared with key stakeholders, including the World Health Organization (WHO) Maternal, Newborn, Child, and Adolescent Health (MNCAH) Research Working Group. Data contributors will share results with local stakeholders. Scientific publications will be published in open-access journals on an ongoing basis.

Published
2022

11. The causes of preterm neonatal deaths in India and Pakistan (PURPOSe): a prospective cohort study

Author

Goudar, Shivaprasad, Dhaded, Sangappa M, Nagmoti, Mahantesh B, Somannavar, Manjunath S, Yogeshkumar, S, Harakuni, Sheetal, Guruprasad, Gowdar, Aradhya, Gayathri H, Nadig, Naveen, Kusgur, Varun, Raghoji, Chaitali R, Sarvamangala, B, Prakash, Veena, Joish, Upendra Kumar, Mangala, G K, Rajashekhar, K S, Sunilkumar, K Byranahalli, Kulkarni, Vardendra, Siddartha, ES, Patil, Lingaraja Gowda C, Pujar, Sneharoopa, Dhananjaya, Shobha, Nagaraj, TS, Jeevika, MU, Harikiran, Reddy R, Saleem, Sarah, Tikmani, Shiyam Sunder, Zafar, Afia, Ahmed, Imran, Uddin, Zeeshan, Ghanchi, Najia, Roujani, Sana, Ariff, Shabina, Sheikh, Lumaan, Mirza, Waseem, Yasmin, Haleema, Raza, Jamal, Prakash, Jai, Haider, Furqan, Aceituno, Anna, Parlberg, Lindsay, Moore, Janet L, Hwang, Kay, Parepelli, Suchita, Kim, Jean, Bann, Carla, McClure, Elizabeth, Goldenberg, Robert, Silver, Robert, Goudar, Shivaprasad S, Kusagur, Varun B, Reza, Sayyeda, Moore, Janet, Bann, Carla M, Silver, Robert M, Goldenberg, Robert L, and McClure, Elizabeth M

Published
2022
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12. The causes of stillbirths in south Asia: results from a prospective study in India and Pakistan (PURPOSe)

Author

Goudar, Shivaprasad, Dhaded, Sangappa M, Nagmoti, Mahantesh B, Somannavar, Manjunath S, Yogeshkumar, S, Guruprasad, Gowdar, Aradhya, Gayathri H, Nadig, Naveen, Kusgur, Varun, Raghoji, Chaitali R, Sarvamangala, B, Prakash, Veena, Joish, Upendra Kumar, Mangala, G K, Rajashekhar, K S, Kumar, Sunil, Kulkarni, Vardendra, Saleem, Sarah, Tikmani, Shiyam Sunder, Zafar, Afia, Ahmed, Imran, Uddin, Zeeshan, Ghanchi, Najia, Ariff, Shabina, Sheikh, Lumaan, Mirza, Waseem, Yasmin, Haleema, Raza, Jamal, Prakash, Jai, Haider, Furqan, Aceituno, Anna, Parlberg, Lindsay, Moore, Janet L, Hwang, Kay, Parepelli, Suchita, Kim, Jean, Bann, Carla, McClure, Elizabeth, Goldenberg, Robert, McClure, Elizabeth M, Goudar, Shivaprasad S, Shobha, Dhananjaya, Roujani, Sana, Reza, Sayyeda, Bann, Carla M, Silver, Robert M, and Goldenberg, Robert L

Published
2022
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13. The impact of risk factors on aspirin's efficacy for the prevention of preterm birth

Author

Nuss, Emily E., Hoffman, Matthew K., Goudar, Shivaprasad S., Kavi, Avinash, Metgud, Mrityunjay, Somannavar, Manjunath, Okitawutshu, Jean, Lokangaka, Adrien, Tshefu, Antoinette, Bauserman, Melissa, Tembo, Abigail Mwapule, Chomba, Elwyn, Carlo, Waldemar A., Figueroa, Lester, Krebs, Nancy F., Jessani, Saleem, Saleem, Sarah, Goldenberg, Robert L., Kurhe, Kunal, Das, Prabir, Hibberd, Patricia L., Achieng, Emmah, Nyongesa, Paul, Esamai, Fabian, Liechty, Edward A., Bucher, Sherri, Goco, Norman, Hemingway-Foday, Jennifer, Moore, Janet, McClure, Elizabeth M., Silver, Robert M., and Derman, Richard J.

Published
2023
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14. Cancer and noncancer mortality among aluminum smelting workers in Badin, North Carolina.

Author

McClure, Elizabeth, Vasudevan, Pavithra, DeBono, Nathan, Robinson, Whitney, Marshall, Stephen, and Richardson, David

Subjects
aluminum, cancer, mortality, occupational cohort, Adult, Aged, Aluminum, Cause of Death, Cohort Studies, Female, Humans, Male, Metallurgy, Middle Aged, Neoplasms, North Carolina, Occupational Diseases, Occupational Exposure
Abstract

BACKGROUND: Badin, North Carolina, hosted an aluminum smelting plant from 1917 to 2007. The Concerned Citizens of West Badin reported suspected excess cancer mortality among former employees. This study aimed to investigate these concerns. METHODS: The study cohort was enumerated from United Steel Workers records of workers employed from 1980 to 2007. Cause-specific mortality rates in the cohort were compared with North Carolina population mortality rates using standardized mortality ratios (SMRs), standardized by age, sex, race, and calendar period. We estimated cause-specific adjusted standardized mortality ratios (aSMRs) using negative controls to mitigate healthy worker survivor bias (HWSB). Standardized rate ratios (SRRs) were calculated to compare mortality rates between workers ever employed vs never employed in the pot room. RESULTS: All-cause mortality among Badin workers was lower than in the general population (SMR: 0.81, 95% confidence interval [CI]: 0.71-0.92). After adjusting for HWSB, excesses for all cancers (aSMR: 1.55, 95% CI: 1.10-2.21), bladder cancer (3.47, 95% CI: 1.25-9.62), mesothelioma (17.33, 95% CI: 5.40-55.59), and respiratory cancer (1.24, 95% CI: 0.77-1.99) were observed. Black males worked the highest proportion of their employed years in the pot room. Potroom workers experienced higher respiratory cancer (SRR: 2.99, 95% CI: 1.23-7.26), bladder cancer (SRR: 1.58, 95% CI: 0.15-15.28), and mesothelioma (SRR: 3.36, 95% CI: 0.21-53.78) mortality rates than never workers in the pot room. CONCLUSIONS: This study responds to concerns of a group of former aluminum workers. The results, while imprecise, suggest excess respiratory and bladder cancers among pot room workers in a contemporary cohort of union employees at a US smelter.

Published
2020

15. Cost-effectiveness of low-dose aspirin for the prevention of preterm birth: a prospective study of the Global Network for Women's and Children's Health Research

Author

Patterson, Jackie K, Neuwahl, Simon, Goco, Norman, Moore, Janet, Goudar, Shivaprasad S, Derman, Richard J, Hoffman, Matthew, Metgud, Mrityunjay, Somannavar, Manjunath, Kavi, Avinash, Okitawutshu, Jean, Lokangaka, Adrien, Tshefu, Antoinette, Bose, Carl L, Mwapule, Abigail, Mwenechanya, Musaku, Chomba, Elwyn, Carlo, Waldemar A, Chicuy, Javier, Figueroa, Lester, Krebs, Nancy F, Jessani, Saleem, Saleem, Sarah, Goldenberg, Robert L, Kurhe, Kunal, Das, Prabir, Patel, Archana, Hibberd, Patricia L, Achieng, Emmah, Nyongesa, Paul, Esamai, Fabian, Bucher, Sherri, Liechty, Edward A, Bresnahan, Brian W, Koso-Thomas, Marion, and McClure, Elizabeth M

Published
2023
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17. The efficacy of low-dose aspirin in pregnancy among women in malaria-endemic countries

Author

Bauserman, Melissa, Leuba, Sequoia I., Hemingway-Foday, Jennifer, Nolen, Tracy L., Moore, Janet, McClure, Elizabeth M., Lokangaka, Adrien, Tsehfu, Antoinette, Patterson, Jackie, Liechty, Edward A., Esamai, Fabian, Carlo, Waldemar A., Chomba, Elwyn, Goldenberg, Robert L., Saleem, Sarah, Jessani, Saleem, Koso-Thomas, Marion, Hoffman, Matthew, Derman, Richard J., Meshnick, Steven R., and Bose, Carl L.

Published
2022
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18. Racial, Ethnic, Sex, and Age Differences in COVID-19 Cases, Hospitalizations, and Deaths Among Incarcerated People and Staff in Correctional Facilities in Six Jurisdictions, United States, March-July 2020.

Author

D'Inverno, Ashley S., Myles, Ranell L., Jamison, Calla R., Williams, Samantha P., Hagan, Liesl M., Handanagic, Senad, Lambert, Lauren A., Clarke, Kristie E. N., Allen, Jeffery, Beard, Olivia, Dusseau, Charles, Feldman, Rachel, Huebsch, Rebecca, Hutchinson, Justine, Kall, Denise, King-Mohr, Jessica, Long, Michael, McClure, Elizabeth S., Meddaugh, Paul, and Pontones, Pam

Published
2024
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19. Admission Temperature and Associated Mortality and Morbidity among Moderately and Extremely Preterm Infants

Author

Laptook, R, Bell, Edward F, Shankaran, Seetha, Boghossian, Nansi S, Wyckoff, Myra H, Kandefer, Sarah, Walsh, Michele, Saha, Shampa, Higgins, Rosemary, Network, Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research, Polin, Richard A, Keszler, Martin, Vohr, Betty R, Hensman, Angelita M, Vieira, Elisa, Little, Emilee, Fanaroff, Avroy A, Hibbs, Anna Marie, Newman, Nancy S, Siner, Bonnie S, Truog, William E, Pallotto, Eugenia K, Kilbride, Howard W, Gauldin, Cheri, Holmes, Anne, Johnson, Kathy, Schibler, Kurt, Kallapur, Suhas G, Grisby, Cathy, Alexander, Barbara, Fischer, Estelle E, Jackson, Lenora, Kirker, Kristin, Jennings, Jennifer, Wuertz, Sandra, Muthig, Greg, Donovan, Edward F, Hessling, Jody, Mersmann, Marcia Worley, Mincey, Holly L, Cotten, C Michael, Goldberg, Ronald N, Finkle, Joanne, Fisher, Kimberley A, Auten, Kathy J, Laughon, Matthew M, Bose, Carl L, Bernhardt, Janice, Clark, Cindy, Stoll, Barbara J, Carlton, David P, Hale, Ellen C, Loggins, Yvonne, Bottcher, Diane I, Archer, Stephanie Wilson, Wright, Linda L, McClure, Elizabeth M, Poindexter, Brenda B, Sokol, Gregory M, Herron, Dianne E, Lemons, James A, Appel, Diana D, Miller, Lucy C, Sanchez, Pablo J, Nelin, Leif D, Jadcherla, Sudarshan R, Luzader, Patricia, Parikh, Nehal A, Nist, Marliese Dion, Fuller, Jennifer, Gutentag, Julie, Jones, Marissa E, McGregor, Sarah, Rodgers, Elizabeth, Ulloa, Jodi A, Wolfe, Tara, Das, Abhik, Wallace, Dennis, Poole, W Kenneth, Zaterka-Baxter, Kristin M, Crawford, Margaret, Gabrio, Jenna, Auman, Jeanette O'Donnell, Huitema, Carolyn Petrie, Hastings, Betty K, Van Meurs, Krisa P, Stevenson, David K, Ball, M Bethany, Proud, Melinda S, Carlo, Waldemar A, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, Devaskar, Uday, Garg, Meena, Chanlaw, Teresa, Geller, Rachel, Colaizy, Tarah T, Ellsbury, Dan L, and Brumbaugh, Jane E

Subjects
Paediatrics, Biomedical and Clinical Sciences, Perinatal Period - Conditions Originating in Perinatal Period, Infant Mortality, Pediatric, Clinical Research, Preterm, Low Birth Weight and Health of the Newborn, Reproductive health and childbirth, Good Health and Well Being, Body Temperature, Female, Fever, Hospital Mortality, Humans, Hypothermia, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Diseases, Intensive Care Units, Neonatal, Logistic Models, Male, Patient Admission, Risk Factors, United States, Generic and Moderate Preterm Subcommittees of the NICHD Neonatal Research Network, hyperthermia, hypothermia, prematurity, survival, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo evaluate the temperature distribution among moderately preterm (MPT, 29-33 weeks) and extremely preterm (EPT, 37.5°C (4.2% vs 6.2%). For EPT infants in 2012-2013 compared with 2002-2003, the percentage of temperatures between 36.5°C and 37.5°C more than doubled and the percentage of temperatures >37.5°C more than tripled. Admission temperature was inversely associated with in-hospital mortality.ConclusionsLow and high admission temperatures are more frequent among EPT than MPT infants. Compared with a decade earlier, fewer EPT infants experience low admission temperatures but more have elevated temperatures. In spite of a change in distribution of NICU admission temperature, an inverse association between temperature and mortality risk persists.

Published
2018

21. Junk food use and neurodevelopmental and growth outcomes in infants in low-resource settings

Author

Chiwila, Melody K., primary, Krebs, Nancy F., additional, Manasyan, Albert, additional, Chomba, Elwyn, additional, Mwenechanya, Musaku, additional, Mazariegos, Manolo, additional, Sami, Neelofar, additional, Pasha, Omrana, additional, Tshefu, Antoinette, additional, Lokangaka, Adrien, additional, Goldenberg, Robert L., additional, Bose, Carl L., additional, Koso-Thomas, Marion, additional, Goco, Norman, additional, Do, Barbara T., additional, McClure, Elizabeth M., additional, Hambidge, K. Michael, additional, Westcott, Jamie E., additional, and Carlo, Waldemar A., additional

Published
2024
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23. Zinc supplementation initiated prior to or during pregnancy modestly impacted maternal status and high prevalence of hypozincemia in pregnancy and lactation: the Women First Preconception Maternal Nutrition Trial

Author

Kemp, Jennifer F., primary, Hambidge, K Michael, additional, Westcott, Jamie L., additional, Ali, Sumera Aziz, additional, Saleem, Sarah, additional, Garcés, Ana, additional, Figueroa, Lester, additional, Somannavar, Manjunath S., additional, Goudar, Shivaprasad S., additional, Long, Julie M., additional, Hendricks, Audrey E., additional, Krebs, Nancy F., additional, Dhaded, Sangappa M., additional, Vernekar, Sunil S., additional, Herekar, Veena R., additional, Yogeshkumar, S., additional, McClure, Elizabeth M., additional, Das, Abhik, additional, Thorsten, Vanessa R., additional, Derman, Richard J., additional, Goldenberg, Robert L., additional, and Koso-Thomas, Marion W., additional

Published
2024
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24. The impact of excluding adverse neonatal outcomes on the creation of gestational weight gain charts among women from low- and middle-income countries with normal and overweight BMI

Author

Bousquet Carrilho, Thais Rangel, primary, Wang, Dongqing, additional, Hutcheon, Jennifer A., additional, Wang, Molin, additional, Fawzi, Wafaie W., additional, Kac, Gilberto, additional, Accrombessi, Manfred, additional, Adu-Afarwuah, Seth, additional, Alves, João Guilherme, additional, Leal de Araújo, Carla Adriane, additional, Arifeen, Shams, additional, Artes, Rinaldo, additional, Ashorn, Per, additional, Ashorn, Ulla, additional, Assefa, Nega, additional, Ayoola, Omolola Olukemi, additional, Azizi, Fereidoun, additional, Bawah, Ahmed Tijani, additional, Behboudi-Gandevani, Samira, additional, Berhane, Yemane, additional, Bernstein, Robin, additional, Bhutta, Zulfiqar, additional, Briand, Valérie, additional, Calvo, Elvira Beatriz, additional, Cardoso, Marly Augusto, additional, Cheng, Yue, additional, Chico-Barba, Gabriela, additional, Clayton, Peter Ellis, additional, Collins, Shalean M., additional, Costello, Anthony M., additional, Cruickshank, John Kennedy, additional, Devakumar, Delanjathan, additional, Dewey, Kathryn G., additional, Dwarkanath, Pratibha, additional, Estrada-Gutierrez, Guadalupe, additional, Fair, Frankie J., additional, Farias, Dayana Rodrigues, additional, Friis, Henrik, additional, Ghosh, Shibani, additional, Girard, Amy Webb, additional, Gomo, Exnevia, additional, Gondwe, Austrida, additional, Hallamaa, Lotta, additional, Hambidge, K. Michael, additional, Hussein, Hawawu, additional, Huybregts, Lieven, additional, Iqbal, Romaina, additional, Katz, Joanne, additional, Khatry, Subarna K., additional, Kolsteren, Patrick, additional, Krebs, Nancy F., additional, Kulmala, Teija, additional, Kumar, Pratap, additional, Kurpad, Anura V., additional, Lachat, Carl, additional, Lartey, Anna, additional, Lauer, Jacqueline M., additional, Li, Qian, additional, Yang, Nianhong, additional, Lipoeto, Nur Indrawaty, additional, López, Laura Beatriz, additional, Loy, See Ling, additional, Maiya, G. Arun, additional, Maleta, Kenneth, additional, Malta, Maíra Barreto, additional, Manandhar, Dharma S., additional, Mangani, Charles, additional, Martínez-Rojano, Hugo, additional, Martin-Prevel, Yves, additional, Martorell, Reynaldo, additional, Matias, Susana L., additional, McClure, Elizabeth M., additional, Melse-Boonstra, Alida, additional, Miller, Joshua D., additional, Mohamad, Marhazlina, additional, Jan Mohamed, Hamid Jan, additional, Moore, Sophie, additional, Mosquera, Paola Soledad, additional, Mridha, Malay Kanti, additional, Munim, Shama, additional, Muñoz-Manrique, Cinthya, additional, Natamba, Barnabas K., additional, Ome-Kaius, Maria, additional, Osrin, David, additional, Perichart-Perera, Otilia, additional, Prentice, Andrew M., additional, Ramachandra, Preetha, additional, Ramakrishnan, Usha, additional, Rivera, Juan, additional, Roberfroid, Dominique, additional, Rodrigues, Patricia Lima, additional, Rodríguez-Cano, Ameyalli, additional, Rogerson, Stephen J., additional, Rondó, Patricia H.C., additional, Sámano, Reyna, additional, Saville, Naomi M., additional, Shivalli, Siddharudha, additional, Shrestha, Bhim P., additional, Shrestha, Robin, additional, Roberto da Silva Júnior, José, additional, Soltani, Hora, additional, Soofi, Sajid, additional, Tehrani, Fahimeh Ramezani, additional, Thomas, Tinku, additional, Tielsch, James M., additional, Unger, Holger W., additional, Vaz, Juliana dos Santos, additional, Worku, Alemayehu, additional, Young, Sera L., additional, Yussif, Adam Bawa, additional, Zeng, Lingxia, additional, Zhong, Chunrong, additional, and Zhu, Zhonghai, additional

Published
2024
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26. Global, regional, and national estimates and trends in stillbirths from 2000 to 2019: a systematic assessment

Author

Hug, Lucia, You, Danzhen, Blencowe, Hannah, Mishra, Anu, Wang, Zhengfan, Fix, Miranda J, Wakefield, Jon, Moran, Allisyn C, Gaigbe-Togbe, Victor, Suzuki, Emi, Blau, Dianna M, Cousens, Simon, Creanga, Andreea, Croft, Trevor, Hill, Kenneth, Joseph, K S, Maswime, Salome, McClure, Elizabeth M, Pattinson, Robert, Pedersen, Jon, Smith, Lucy K, Zeitlin, Jennifer, and Alkema, Leontine

Published
2021
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28. Growth from Birth Through Six Months for Infants of Mothers in the “Women First” Preconception Maternal Nutrition Trial

Author

Gado, Justin, Somannavar, Manjunath S., Herekar, Veena, Pasha, Omrana, Khan, Umber, McClure, Elizabeth M., Koso-Thomas, Marion, Krebs, Nancy F., Hambidge, K. Michael, Westcott, Jamie L., Garcés, Ana L., Figueroa, Lester, Tsefu, Antoinette K., Lokangaka, Adrien L., Goudar, Shivaprasad S., Dhaded, Sangappa M., Saleem, Sarah, Ali, Sumera Aziz, Bose, Carl L., Derman, Richard J., Goldenberg, Robert L., Thorsten, Vanessa R., Sridhar, Amaanti, Chowdhury, Dhuly, and Das, Abhik

Published
2021
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29. Twenty-five year occupational homicide mortality trends in North Carolina: 1992-2017.

Author

Martin, Chelsea L., Richardson, David, Richey, Morgan, Nocera, Maryalice, Cantrell, John, McClure, Elizabeth S., Martin, Amelia T., Marshall, Stephen W., and Ranapurwala, Shabbar

Subjects
PREVENTION of homicide, PREVENTION of violence in the workplace, MORTALITY, RESEARCH funding, WORK environment, VIOLENCE in the workplace, DESCRIPTIVE statistics, CAUSES of death, DECISION making, CRIME victims, RACISM, HOMICIDE, QUALITY of life, COMPARATIVE studies, SOCIODEMOGRAPHIC factors, ORGANIZATIONAL goals, INDUSTRIAL relations, TIME, INDUSTRIAL safety, INDUSTRIAL hygiene, PREVENTIVE health services, MANAGEMENT
Published
2024
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30. Neurodevelopment of Children Whose Mothers Were Randomized to Low-Dose Aspirin During Pregnancy

Author

Hoffman, Matthew K., primary, Goudar, Shivaprasad, additional, Dhaded, Sangappa, additional, Figueroa, Lester, additional, Mazariegos, Manolo, additional, Krebs, Nancy F., additional, Westcott, Jamie, additional, Tikmani, Shiyam Sunder, additional, Karim, Fatima, additional, Saleem, Sarah, additional, Goldenberg, Robert L., additional, Lokangaka, Adrien, additional, Tshefu, Antoinette, additional, Bauserman, Melissa, additional, Patel, Archana, additional, Das, Prabir, additional, Hibberd, Patricia, additional, Chomba, Elwyn, additional, Mwenchanya, Musaku, additional, Carlo, Waldemar A., additional, Trotta, Marissa, additional, Williams, Alexis, additional, Moore, Janet, additional, Nolen, Tracy, additional, Goco, Norman, additional, McClure, Elizabeth M., additional, Lobo, Michele A., additional, Cunha, Andrea B., additional, and Derman, Richard J., additional

Published
2024
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34. Predictors of Preterm Neonatal Mortality in India and Pakistan: A Secondary Analysis of Data from PURPOSe Study

Author

Tikmani, Shiyam Sunder, primary, Saleem, Sarah, additional, Sadia, Afreen, additional, M. Bann, Carla, additional, Bozdar, Muhammad Hayat, additional, Raza, Jamal, additional, Dhaded, Sangappa M., additional, Goudar, Shivaprasad S., additional, Gowdar, Guruparasad, additional, Yasmin, Haleema, additional, McClure, Elizabeth M., additional, and Goldenberg, Robert L., additional

Published
2024
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35. Impact of Optimized Breastfeeding on the Costs of Necrotizing Enterocolitis in Extremely Low Birthweight Infants

Author

Colaizy, Tarah T, Bartick, Melissa C, Jegier, Briana J, Green, Brittany D, Reinhold, Arnold G, Schaefer, Andrew J, Bogen, Debra L, Schwarz, Eleanor Bimla, Stuebe, Alison M, Jobe, Alan H, Oh, William, Vohr, Betty R, Walden, Rachel V, Alksninis, Barbara, Hensman, Angelita M, Leonard, Martha R, Noel, Lucy, Leach, Teresa M, Watson, Victoria E, Fanaroff, Avroy A, Walsh, Michele C, Wilson-Costello, Deanne E, Newman, Nancy S, Siner, Bonnie S, Friedman, Harriet G, Donovan, Edward F, Schibler, Kurt, Steichen, Jean J, Alexander, Barbara, Grisby, Cathy, Mersmann, Marcia Worley, Mincey, Holly L, Hessling, Jody, Gratton, Teresa L, Stoll, Barbara J, Adams-Chapman, Ira, Hale, Ellen C, LaRossa, Maureen Mulligan, Carter, Sheena, Higgins, Rosemary D, Wright, Linda L, McClure, Elizabeth M, Poindexter, Brenda B, Lemons, James A, Dusick, Anna M, Kardatzke, Darlene, Lytle, Carolyn, Appel, Diana D, Bohnke, Lon G, Eaken, Greg, Herron, Dianne E, Miller, Lucy C, Richard, Leslie, Wilson, Leslie Dawn, Das, Abhik, Poole, W Kenneth, Wrage, Lisa Ann, Hastings, Betty K, Auman, Jeanette O'Donnell, Taylor, Sarah, Stevenson, David K, Hintz, Susan R, Ball, M Bethany, Kohn, Jean G, Baran, Joan M, Lee-Ancajas, Julie C, St. John, Nicholas H, Carlo, Waldemar A, Ambalavanan, Namasivayam, Nelson, Kathleen G, Peralta-Carcelen, Myriam, Bailey, Kirstin J, Biasini, Fred J, Chopko, Stephanie A, Collins, Monica V, Cosby, Shirley S, Phillips, Vivien A, Rector, Richard V, Finer, Neil N, Vaucher, Yvonne E, Anderson, Jack M, Rasmussen, Maynard R, Arnell, Kathy, Demetrio, Clarence, Fuller, Martha G, Henderson, Christopher, Posin, Donna, Bell, Edward F, Bauer, Charles R, Duara, Shahnaz, Worth, Amy Mur, Everett-Thomas, Ruth, Diaz, Alexis N, Mathews, Elaine O, Hamlin-Smith, Kasey, Jean-Gilles, Lisa, Calejo, Maria, and Frade, Silvia M

Subjects
Paediatrics, Biomedical and Clinical Sciences, Perinatal Period - Conditions Originating in Perinatal Period, Nutrition, Infant Mortality, Digestive Diseases, Clinical Research, Pediatric, Preterm, Low Birth Weight and Health of the Newborn, Rare Diseases, Prevention, Prevention of disease and conditions, and promotion of well-being, 3.3 Nutrition and chemoprevention, Reproductive health and childbirth, Good Health and Well Being, Breast Feeding, Enterocolitis, Necrotizing, Health Care Costs, Humans, Infant Formula, Infant, Extremely Low Birth Weight, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Milk, Human, Models, Economic, Monte Carlo Method, United States, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, economic analysis, human milk, monte carlo modeling, necrotizing enterocolitis, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

ObjectiveTo estimate risk of necrotizing enterocolitis (NEC) for extremely low birth weight (ELBW) infants as a function of preterm formula (PF) and maternal milk intake and calculate the impact of suboptimal feeding on the incidence and costs of NEC.Study designWe used aORs derived from the Glutamine Trial to perform Monte Carlo simulation of a cohort of ELBW infants under current suboptimal feeding practices, compared with a theoretical cohort in which 90% of infants received at least 98% human milk.ResultsNEC incidence among infants receiving ≥98% human milk was 1.3%; 11.1% among infants fed only PF; and 8.2% among infants fed a mixed diet (P = .002). In adjusted models, compared with infants fed predominantly human milk, we found an increased risk of NEC associated with exclusive PF (aOR = 12.1, 95% CI 1.5, 94.2), or a mixed diet (aOR 8.7, 95% CI 1.2-65.2). In Monte Carlo simulation, current feeding of ELBW infants was associated with 928 excess NEC cases and 121 excess deaths annually, compared with a model in which 90% of infants received ≥98% human milk. These models estimated an annual cost of suboptimal feeding of ELBW infants of $27.1 million (CI $24 million, $30.4 million) in direct medical costs, $563 655 (CI $476 191, $599 069) in indirect nonmedical costs, and $1.5 billion (CI $1.3 billion, $1.6 billion) in cost attributable to premature death.ConclusionsAmong ELBW infants, not being fed predominantly human milk is associated with an increased risk of NEC. Efforts to support milk production by mothers of ELBW infants may prevent infant deaths and reduce costs.

Published
2016

36. Home-Based Early Intervention and the Influence of Family Resources on Cognitive Development.

Author

Bann, Carla M, Wallander, Jan L, Do, Barbara, Thorsten, Vanessa, Pasha, Omrana, Biasini, Fred J, Bellad, Roopa, Goudar, Shivaprasad, Chomba, Elwyn, McClure, Elizabeth, and Carlo, Waldemar A

Subjects
Humans, Longitudinal Studies, Child Development, Intelligence, Cognition, Age Factors, Socioeconomic Factors, Adolescent, Adult, Child, Preschool, Infant, Home Care Services, Female, Male, Young Adult, Early Intervention, Educational, Child, Preschool, Early Intervention, Pediatrics, Medical and Health Sciences, Psychology and Cognitive Sciences
Abstract

ObjectiveTo investigate whether early developmental intervention (EDI) can positively affect the trajectories of cognitive development among children from low-resource families.MethodsLongitudinal analyses were conducted of data from 293 children in the Brain Research to Ameliorate Impaired Neurodevelopment Home-based Intervention Trial, a randomized controlled trial of a home-based EDI program, to examine trajectories of Bayley Scales of Infant Development-Second Edition Mental Development Index (MDI) scores from 12 to 36 months of age among young children from high- and low-resource families in 3 low- to middle-resource countries.ResultsA 3-way interaction among family resources, intervention group, and age was statistically significant after controlling for maternal, child, and birth characteristics (Wald χ(2)(1) = 9.41, P = .002). Among children of families with high resources, both the intervention and control groups had significant increases in MDI scores over time (P < .001 and P = .002, respectively), and 36-month MDI scores for these 2 groups did not differ significantly (P = .602). However, in families with low resources, the EDI group displayed greater improvement, resulting in significantly higher 36-month MDI scores than the control group (P < .001). In addition, the 36-month MDI scores for children in families with low resources receiving EDI did not differ significantly from children from high-resource families in either the EDI (P = .509) or control (P = .882) groups.ConclusionsA home-based EDI during the first 3 years of life can substantially decrease the developmental gap between children from families with lower versus higher resources, even among children in low- to middle-resource countries.

Published
2016

38. Dose of early intervention treatment during children’s first 36 months of life is associated with developmental outcomes: an observational cohort study in three low/low-middle income countries

Author

Wallander, Jan L, Biasini, Fred J, Thorsten, Vanessa, Dhaded, Sangappa M, de Jong, Desiree M, Chomba, Elwyn, Pasha, Omrana, Goudar, Shivaprasad, Wallace, Dennis, Chakraborty, Hrishikesh, Wright, Linda L, McClure, Elizabeth, and Carlo, Waldemar A

Subjects
Pediatric, Prevention, Clinical Research, Behavioral and Social Science, Good Health and Well Being, Adult, Child Development, Child, Preschool, Cohort Studies, Developing Countries, Developmental Disabilities, Female, Home Care Services, Humans, India, Infant, Infant, Newborn, Male, Neuropsychological Tests, Pakistan, Parents, Program Evaluation, Rural Population, Zambia, Treatment dose, Early developmental intervention, Neurodevelopmental disability, Birth asphyxia, Developing countries, Paediatrics and Reproductive Medicine, Pediatrics
Abstract

BackgroundThe positive effects of early developmental intervention (EDI) on early child development have been reported in numerous controlled trials in a variety of countries. An important aspect to determining the efficacy of EDI is the degree to which dosage is linked to outcomes. However, few studies of EDI have conducted such analyses. This observational cohort study examined the association between treatment dose and children's development when EDI was implemented in three low and low-middle income countries as well as demographic and child health factors associated with treatment dose.MethodsInfants (78 males, 67 females) born in rural communities in India, Pakistan, and Zambia received a parent-implemented EDI delivered through biweekly home visits by trainers during the first 36 months of life. Outcome was measured at age 36 months with the Mental (MDI) and Psychomotor (PDI) Development Indices of the Bayley Scales of Infant Development-II. Treatment dose was measured by number of home visits completed and parent-reported implementation of assigned developmental stimulation activities between visits. Sociodemographic, prenatal, perinatal, and child health variables were measures as correlates.ResultsAverage home visits dose exceeded 91% and mothers engaged the children in activities on average 62.5% of days. Higher home visits dose was significantly associated with higher MDI (mean for dose quintiles 1-2 combined = 97.8, quintiles 3-5 combined = 103.4, p = 0.0017). Higher treatment dose was also generally associated with greater mean PDI, but the relationships were non-linear. Location, sociodemographic, and child health variables were associated with treatment dose.ConclusionsReceiving a higher dose of EDI during the first 36 months of life is generally associated with better developmental outcomes. The higher benefit appears when receiving ≥91% of biweekly home visits and program activities on ≥67% of days over 3 years. It is important to ensure that EDI is implemented with a sufficiently high dose to achieve desired effect. To this end groups at risk for receiving lower dose can be identified and may require special attention to ensure adequate effect.

Published
2014

39. Major causes of death in preterm infants in selected hospitals in Ethiopia (SIP): a prospective, cross-sectional, observational study

Author

Muhe, Lulu M, McClure, Elizabeth M, Nigussie, Assaye K, Mekasha, Amha, Worku, Bogale, Worku, Alemayehu, Demtse, Asrat, Eshetu, Beza, Tigabu, Zemene, Gizaw, Mahlet A, Workneh, Netsanet, Girma, Abayneh, Asefa, Mesfin, Portales, Ramon, Bekele, Tiruzer, Bezabih, Mesele, Metaferia, Gesit, Gashaw, Mulatu, Abebe, Bewketu, Berta, Hailu, Alemu, Addisu, Desta, Tigist, Hailu, Rahell, Gebreyesus, Goitom, Aynalem, Sara, Abdissa, Alemseged L, Pfister, Riccardo, Bonger, Zelalem Tazu, Gizaw, Solomon, Abebe, Tamrat, Berhane, Melkamu A, Bekuretsion, Yonas, Dhaded, Sangappa, Patterson, Janna, and Goldenberg, Robert L

Published
2019
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40. Global, Regional, and National Estimates and Trends in Stillbirths From 2000 to 2019: A Systematic Assessment

Author

Hug, Lucia, You, Danzhen, Blencowe, Hannah, Mishra, Anu, Wang, Zhengfan, Fix, Miranda J., Wakefield, Jon, Moran, Allisyn C., Gaigbe-Togbe, Victor, Suzuki, Emi, Blau, Dianna M., Cousens, Simon, Creanga, Andreea, Croft, Trevor, Hill, Kenneth, Joseph, K. S., Maswime, Salome, McClure, Elizabeth M., Pattinson, Robert, Pedersen, Jon, Smith, Lucy K., Zeitlin, Jennifer, and Alkema, Leontine

Published
2022
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42. Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm

Author

Jobe, Alan H., Caplan, Michael S., Laptook, Abbot R., Vohr, Betty R., Oh, William, Hensman, Angelita M., Alksninis, Barbara, Andrews, Dawn, Angela, Kristen, Barnett, Susan, Cashore, Bill, Caskey, Melinda, Francis, Kim, Gingras, Dan, Johnson, Katharine, Leach, Theresa M., Stephens, Bonnie E., Watson, Victoria E., Walsh, Michele C., Fanaroff, Avroy A., Newman, Nancy S., Wilson-Costello, Deanne E., Siner, Bonnie S., Zadell, Arlene, DiFiore, Julie, Bhola, Monika, Friedman, Harriet G., Yalcinkaya, Gulgun, Bulas, Dorothy, Goldberg, Ronald N., Cotten, C. Michael, Goldstein, Ricki F., Ashley, Patricia, Auten, Kathy J., Fisher, Kimberley A., Foy, Katherine A., Freedman, Sharon F., Gustafson, Kathryn E., Lohmeyer, Melody B., Malcolm, William F., Wallace, David K., Carlton, David P., Stoll, Barbara J., Adams-Chapman, Ira, Buchter, Susie, Piazza, Anthony J., Carter, Sheena, Fritz, Sobha, Hale, Ellen C., Hutchinson, Amy K., LaRossa, Maureen Mulligan, Higgins, Rosemary D., Archer, Stephanie Wilson, Sokol, Gregory M., Poindexter, Brenda B., Dusick, Anna M., Lemons, James A., Wilson, Leslie D., Hamer, Faithe, Cook, Ann B., Herron, Dianne E., Lytle, Carolyn, Minnich, Heike M., Berberich, Mary Anne, Blaisdell, Carol J., Gail, Dorothy B., Kiley, James P., Das, Abhik, Gantz, Marie G., Newman, Jamie E., Cheng, Helen, Hastings, Betty K., McClure, Elizabeth M., Auman, Jeanette O'Donnell, Huitema, Carolyn Petrie, Poole, W. Kenneth, Pickett, James W., II, Wallace, Dennis, Wrage, Lisa A., Zaterka-Baxter, Kristin M., Van Meurs, Krisa P., Stevenson, David K., Ball, M. Bethany, Barnes, Patrick D., Bentley, Barbara, Bruno, Elizabeth F., DeAnda, Maria Elena, DeBattista, Anne M., Kohn, Jean G., Proud, Melinda S., Pyle, Renee P., Weiss, Hali E., Frantz, Ivan D., III, Fiascone, John M., McGowan, Elisabeth C., Furey, Anne, MacKinnon, Brenda L., Nylen, Ellen, Brussa, Ana, Sibley, Cecelia, Carlo, Waldemar A., Ambalavanan, Namasivayam, Collins, Monica V., Cosby, Shirley S., Phillips, Vivien A., Bailey, Kirstin J., Biasini, Fred J., Hopkins, Maria, Johnston, Kristen C., Nelson, Kathleen G., Patterson, Cryshelle S., Rector, Richard V., Rodriguez, Leslie, Soong, Amanda, Whitley, Sally, York, Sheree, Finer, Neil N., Rasmussen, Maynard R., Wozniak, Paul R., Vaucher, Yvonne E., Rich, Wade, Arnell, Kathy, Barbieri-Welge, Rene, Ben-Tall, Ayala, Bridge, Renee, Demetrio, Clarence, Fuller, Martha G., Ito, Elaine, Lukasik, Meghan, Pontillo, Deborah, Posin, Donna, Runyan, Cheryl, Wilkes, James, Zlotnik, Paul, Bell, Edward F., Widness, John A., Acarregui, Michael J., Klein, Jonathan M., Colaizy, Tarah T., Johnson, Karen J., Eastman, Diane L., Duara, Shahnaz, Bauer, Charles R., Everett-Thomas, Ruth, Calejo, Maria, Diaz, Alexis N., Frade Eguaras, Silvia M., Garcia, Andrea, Hamlin-Smith, Kasey, Berkowits, Michelle Harwood, Hiriart-Fajardo, Sylvia, Mathews, Elaine O., Pierre, Helina, Riguard, Arielle, Stroerger, Alexandra, Watterberg, Kristi L., Ohls, Robin K., Fuller, Janell, Rohr, Julie, Lacy, Conra Backstrom, Lowe, Jean, Montman, Rebecca, Brown, Sandra, Laroia, Nirupama, Phelps, Dale L., Myers, Gary J., Markowitz, Gary D., Reubens, Linda J., Hust, Diane, Augostino, Lisa, Johnson, Julie Babish, Burnell, Erica, Gelbard, Harris, Jensen, Rosemary L., Kushner, Emily, Merzbach, Joan, Mink, Jonathan, Torres, Carlos, Wang, David, Yost, Kelley, Sánchez, Pablo J., Rosenfeld, Charles R., Salhab, Walid A., Heyne, Roy J., Adams, Sally S., Allen, James, Grau, Laura, Guzman, Alicia, Hensley, Gaynelle, Heyne, Elizabeth T., Hickman, Jackie F., Leps, Melissa H., Madden, Linda A., Martin, Melissa, Miller, Nancy A., Morgan, Janet S., Solis, Araceli, Torres, Lizette E., Boatman, Catherine Twell, Vasil, Diana M., Kennedy, Kathleen A., Tyson, Jon E., Evans, Patricia W., Akpa, Esther G., Alaniz, Nora I., Harris, Beverly Foley, Green, Charles, Jiminez, Margarita, Lis, Anna E., Martin, Sarah, McDavid, Georgia E., Morris, Brenda H., Poundstone, Margaret L., Reddoch, Stacy, Siddiki, Saba, Pierce Tate, Patti L., Wright, Sharon L., Yoder, Bradley A., Faix, Roger G., Baker, Shawna, Bird, Karie, Bullwinkle, Anna E., Burnett, Jill, Cole, Laura, Osborne, Karen A., Spencer, Cynthia, Steele, R. Edison, Steffen, Michael, Weaver-Lewis, Kimberlee, O'Shea, T. Michael, Dillard, Robert G., Washburn, Lisa K., Peters, Nancy J., Jackson, Barbara G., Chiu, Korinne, Allred, Deborah Evans, Goldstein, Donald J., Halfond, Raquel, Peterson, Carroll, Waldrep, Ellen L., Welch, Cherrie D., Morris, Melissa Whalen, Hounshell, Gail Wiley, Shankaran, Seetha, Sood, Beena G., Slovis, Thomas L., Pappas, Athina, Bara, Rebecca, Billian, Elizabeth, Goldston, Laura A., Johnson, Mary, Duncan, Andrea F., Bann, Carla M., Dempsey, Allison, Peralta-Carcelen, Myriam, and Hintz, Susan

Published
2019
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43. Development of children at risk for adverse outcomes participating in early intervention in developing countries: a randomized controlled trial

Author

Wallander, Jan L, Bann, Carla M, Biasini, Fred J, Goudar, Shivaprasad S, Pasha, Omrana, Chomba, Elwyn, McClure, Elizabeth, and Carlo, Waldemar A

Subjects
Mind and Body, Pediatric AIDS, Prevention, Clinical Research, Behavioral and Social Science, Clinical Trials and Supportive Activities, Pediatric, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, Prevention of disease and conditions, and promotion of well-being, 7.1 Individual care needs, Management of diseases and conditions, Reproductive health and childbirth, Mental health, Asphyxia Neonatorum, Child, Preschool, Developing Countries, Developmental Disabilities, Early Intervention, Educational, Female, Humans, India, Infant, Male, Pakistan, Treatment Outcome, Zambia, Early developmental intervention, low resource countries, birth trauma, at risk, Clinical Sciences, Psychology, Cognitive Sciences, Developmental & Child Psychology
Abstract

BackgroundPrevious research has indicated positive effects of early developmental intervention (EDI) on the development of children in developing countries. Few studies, however, have examined longitudinally when differential treatment effects may be observed and whether differential outcomes are associated with exposure to different risk factors and country of implementation. Also, birth asphyxia as a risk condition has not been well studied. To address these limitations, we conducted a randomized controlled trial to test the hypothesis that there will be differential developmental trajectories favoring those who receive EDI versus a health education intervention in children in rural areas of India, Pakistan, and Zambia.MethodsChildren with and without birth asphyxia were randomized to EDI or control intervention, which was implemented by parents who received training in biweekly home visits initiated before child age 1 month and continuing until 36 months. Development was assessed in 376 children at ages 12, 24, and 36 months using the Bayley Scales of Infant Development and Ages & Stages Questionnaire administered by evaluators blind to intervention assignment and risk condition.ResultsLongitudinal mixed model analysis indicated that EDI resulted in better development over 36 months in cognitive abilities, regardless of risk condition, maternal resources, child gender, or country. Psychomotor development and parent-reported general development showed similar trends as for cognitive abilities, but were not statistically different between intervention conditions. Developmental differences were observed first at 36 months of age.ConclusionEarly developmental intervention has promise for improving development in children across developing countries when exposed to various risk conditions. EDI should be one prominent approach used to begin to address long-term outcomes and intergenerational transmission of poverty.

Published
2014

44. Developmental trajectories of children with birth asphyxia through 36months of age in low/low–middle income countries

Author

Wallander, Jan L, Bann, Carla, Chomba, Elwyn, Goudar, Shivaprasad S, Pasha, Omrana, Biasini, Fred J, McClure, Elizabeth M, Thorsten, Vanessa, Wallace, Dennis, and Carlo, Waldemar A

Subjects
Pediatric, Preterm, Low Birth Weight and Health of the Newborn, Perinatal Period - Conditions Originating in Perinatal Period, Infant Mortality, Physical Injury - Accidents and Adverse Effects, Clinical Research, Reproductive health and childbirth, Asphyxia Neonatorum, Child, Preschool, Cohort Studies, Developing Countries, Developmental Disabilities, Humans, India, Infant, Infant, Newborn, Models, Statistical, Pakistan, Prospective Studies, Psychomotor Disorders, Resuscitation, Zambia, Birth asphyxia, Low resource countries, Developmental outcomes, Neurodevelopmental disability, Clinical Sciences, Paediatrics and Reproductive Medicine, Cognitive Sciences, Pediatrics
Abstract

BackgroundResuscitation following birth asphyxia reduces mortality, but may be argued to increase risk for neurodevelopmental disability in survivors.AimsTo test the hypothesis that development of infants who received resuscitation following birth asphyxia is not significantly different through 36months of age from infants who had healthy births.Study designProspective observational cohort design comparing infants exposed to birth asphyxia with resuscitation or healthy birth.SubjectsA random sample of infants with birth asphyxia who received bag-and-mask resuscitation was selected from birth records in selected communities in 3 countries.Exclusion criteriabirth weight

Published
2014

45. Developmental trajectories of children with birth asphyxia through 36 months of age in low/low-middle income countries.

Author

Wallander, Jan L, Bann, Carla, Chomba, Elwyn, Goudar, Shivaprasad S, Pasha, Omrana, Biasini, Fred J, McClure, Elizabeth M, Thorsten, Vanessa, Wallace, Dennis, and Carlo, Waldemar A

Subjects
Humans, Psychomotor Disorders, Asphyxia Neonatorum, Resuscitation, Models, Statistical, Cohort Studies, Prospective Studies, Developmental Disabilities, Developing Countries, Child, Preschool, Infant, Infant, Newborn, Zambia, India, Pakistan, Birth asphyxia, Developmental outcomes, Low resource countries, Neurodevelopmental disability, Models, Statistical, Child, Preschool, Newborn, Pediatrics, Clinical Sciences, Cognitive Sciences, Paediatrics and Reproductive Medicine
Abstract

BackgroundResuscitation following birth asphyxia reduces mortality, but may be argued to increase risk for neurodevelopmental disability in survivors.AimsTo test the hypothesis that development of infants who received resuscitation following birth asphyxia is not significantly different through 36months of age from infants who had healthy births.Study designProspective observational cohort design comparing infants exposed to birth asphyxia with resuscitation or healthy birth.SubjectsA random sample of infants with birth asphyxia who received bag-and-mask resuscitation was selected from birth records in selected communities in 3 countries.Exclusion criteriabirth weight

Published
2014

46. Maternal age extremes and adverse pregnancy outcomes in low-resourced settings

Author

Nyongesa, Paul, primary, Ekhaguere, Osayame A., additional, Marete, Irene, additional, Tenge, Constance, additional, Kemoi, Milsort, additional, Bann, Carla M., additional, Bucher, Sherri L., additional, Patel, Archana B., additional, Hibberd, Patricia L., additional, Naqvi, Farnaz, additional, Saleem, Sarah, additional, Goldenberg, Robert L., additional, Goudar, Shivaprasad S., additional, Derman, Richard J., additional, Krebs, Nancy F., additional, Garces, Ana, additional, Chomba, Elwyn, additional, Carlo, Waldemar A., additional, Mwenechanya, Musaku, additional, Lokangaka, Adrien, additional, Tshefu, Antoinette K., additional, Bauserman, Melissa, additional, Koso-Thomas, Marion, additional, Moore, Janet L., additional, McClure, Elizabeth M., additional, Liechty, Edward A., additional, and Esamai, Fabian, additional

Published
2023
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48. Placental inflammation and pregnancy outcomes: A prospective, observational study in South Asia: The PURPOSe study

Author

Ahmed, Imran, primary, Ghanchi, Najia Karim, additional, Sunder Tikmani, Shiyam, additional, Hwang, Kay, additional, Zafar, Afia, additional, Saleem, Sarah, additional, Uddin, Zeeshan, additional, Harakuni, Sheetal, additional, Somannavar, Manjunath S., additional, Kulkarni, Vardendra, additional, Guruprasad, Gowder, additional, Goudar, Shivaprasad S., additional, Kim, Jean, additional, McClure, Elizabeth M., additional, and Goldenberg, Robert L., additional

Published
2023
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49. Can the date of last menstrual period be trusted in the first trimester? Comparisons of gestational age measures from a prospective cohort study in six low-income to middle-income countries

Author

Patel, Archana, primary, Bann, Carla M, additional, Thorsten, Vanessa R, additional, Rao, Sowmya R, additional, Lokangaka, Adrien, additional, Tshefu Kitoto, Antoinette, additional, Bauserman, Melissa, additional, Figueroa, Lester, additional, Krebs, Nancy F, additional, Esamai, Fabian, additional, Bucher, Sherri, additional, Saleem, Sarah, additional, Goldenberg, Robert L, additional, Chomba, Elwyn, additional, Carlo, Waldemar A, additional, Goudar, Shivaprasad, additional, Derman, Richard, additional, Koso-Thomas, Marion, additional, McClure, Elizabeth, additional, and Hibberd, Patricia L, additional

Published
2023
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50. An approach to identify a minimum and rational proportion of caesarean sections in resource-poor settings: a global network study

Author

Belizán, José M, Minckas, Nicole, McClure, Elizabeth M, Saleem, Sarah, Moore, Janet L, Goudar, Shivaprasad S, Esamai, Fabian, Patel, Archana, Chomba, Elwyn, Garces, Ana L, Althabe, Fernando, Harrison, Margo S, Krebs, Nancy F, Derman, Richard J, Carlo, Waldemar A, Liechty, Edward A, Hibberd, Patricia L, Buekens, Pierre M, and Goldenberg, Robert L

Published
2018
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