Search

An upper-level undergraduate course that explores ethics in chemistry and the impact of chemical innovations on society has been developed. Goals of this course were to promote student recognition of ethical considerations in chemical innovations and chemical research and demonstrate the link between the application of chemical innovations and the formation of government policy. The course involved presentation and discussion on multiple topics along with student writing about a use of chemistry in society and expression of students' own opinions based on their literature research. The SENCER-SALG assessment was used to elicit students' opinions on their experience in this course. Student responses indicate that the course had a positive influence on their recognition of chemistry in society and their likelihood of civic engagement. (Contains 3 tables and 1 figure.)

Results show that zinc cofactor is a structural component of the McbB subunit of the purified multimeric enzyme, the microcin B17 synthetase. Data indicate cysteine residue serves as the metal ligand.

Access to recommended second-line treatments is limited for patients who fail initial hepatitis C virus (HCV) therapy in low- and middle-income countries. Alternative regimens and associated outcomes are not well understood. Through a pooled analysis of national program data in Egypt, Georgia, and Myanmar, we observed SVR rates >90% for alternative retreatment regimens. [ABSTRACT FROM AUTHOR]

Abstract Dr. Pedro Cahn, International AIDS Society (IAS) President and Mr. Craig McClure, IAS Executive Director, provide their thoughts and analysis on the current and future role of the IAS as part of the global response to HIV/AIDS.

Introduction Vertical transmission of HIV from mother to child during pregnancy, childbirth, and breastfeeding can be reduced to PMTCT has been widely implemented in developing countries for a number of [...], Introduction: Mother?to?child transmission of HIV can be reduced to Methods: To examine the availability, feasibility, acceptability and possible negative consequences of the Minimum PMTCT Package, data from a 2009 qualitative and quantitative study and a 2010 facility assessment were used. To examine the effects on ANC and facility?based delivery rates, a difference?in?differences analytic approach was applied to 2009 Demographic and Health Survey data for HIV?tested women who gave birth before and after Minimum PMTCT Package implementation. Results: The Minimum PMTCT Package was feasible and acceptable to providers and clients. Problems with test kit and medicine stock?outs occurred, and 46% of women did not receive the Minimum PMTCT Package until at least their second ANC visit. Providing adequate instruction on the use of multiple medications represented a challenge. The proportion of HIV?positive women delivering in facilities declined after Minimum PMTCT Package implementation, although it increased among HIV?negative women (difference?in?differences=14.5%, p=0.05). The mean number of ANC visits declined more among HIV?positive women than among HIV?negative women after implementation, though the difference was not statistically significant (p=0.09). Changes in the percentage of women receiving?4 ANC visits did not differ between the two groups. Conclusions: If supply issues can be resolved and adequate client educational materials provided, take?away co?packages have the potential to increase access to PMTCT commodities in countries where women have limited access to health services. However, efforts must be made to carefully monitor potential changes in ANC visits and facility deliveries, and further evaluation of adherence, safety and effectiveness are needed.

Information about a puzzle that can be used to combine information and solve a chemical problem is presented. The puzzle, which deals with determination of the amino acid sequence of a peptide, requires knowledge of structure and characteristics of amino acid side chains, as well as terminology used to describe peptides.

Tri L12C and Tri L16C are amphiphilic peptides composed of 30 amino acids with cysteine in either the 12 or 16 position of the sequence. The preference of Arsenic(As)(III) for trigonal-pyramidal geometry and thiol coordination is used to direct folding of the peptide to form three-helix bundles under all conditions studied.

On behalf of the International AIDS Society (IAS), Medscape, and our editors, we are pleased to introduce eJIAS: eJournal of the International AIDS Society, a new peer‐reviewed journal dedicated to [...]