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262 results on '"McCloskey, B"'

1. NOVEL MULTI-MODULAR TOOLS TO ENHANCE TREGS FOR CELL AND GENE THERAPY: CAR, PHENOTYPE LOCK™ AND SYNTHETIC CYTOKINE SIGNALING

Author

Tung, S., primary, McCloskey, B., additional, Manzoor, S., additional, Irfan, M., additional, Karegli, J., additional, Anstee, J., additional, Romano, M., additional, Shahrabi, Y., additional, Billman, A., additional, McGovern, J.L., additional, Penston, D., additional, Belmonte, N., additional, Martinez-Llordella, M., additional, and Lodie, T., additional

Published
2024
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3. Recent findings within the microbiota–gut–brain–endocrine metabolic interactome

Author

Obrenovich M, Sankar Chittoor Mana T, Rai H, Shola D, Sass C, McCloskey B, and Levison BS

Subjects
neurotransmitters, gut brain axis, metabolomics, microbiota, microbiome, Pathology, RB1-214
Abstract

Mark Obrenovich,1–4 Thriveen Sankar Chittoor Mana,5 Herleen Rai,2 Dorjee Shola,4,6 Christopher Sass,2,3 Benjamin McCloskey,4 Bruce S Levison7 1Pathology and Laboratory Medicine Service, 2Research Service, Cleveland Veterans Affairs Medical Center, 3Department of Chemistry, Cleveland State University, 4Gilgamesh Foundation, 5Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, OH, 6Gene Targeting Resource Center, The Rockefeller University, New York, NY, 7Department of Pediatrics, University of Toledo, Toledo, OH, USA Purpose of review: We have established that many metabolic biomes exist within the complex mammalian gut. Substantial metabolism occurs within these biomes and is called co-metabolism of the host and resident microorganisms. This gut–brain–endocrine metabolic interaction emphasizes how bacteria can affect the brain and the hormonal axes in the process of co-metabolism. This review highlights new findings in this regard. Recent findings: In this review, we explore how the gut microbiota affect the development and regulation of the hypothalamic–pituitary–adrenal axis and neurochemistry from mental health and behavioral health to memory, depression, mood, anxiety, obesity, and the development of the blood–brain barrier. Summary: This review describes the implications of the findings for clinical practice or research. Interaction of small molecules within these biomes is now described collectively as a “metabolic interactome”. Metabolites of the gut–brain–endocrine axis and our overall gut health constantly shape the host phenotype in ways previously unimagined, and this niche represents potential targets for treatment and drug design, since the interaction or biochemical interplay results in net metabolite production and/or end products to exercise either positive or negative effects on human health. Keywords: neurotransmitters, gut brain axis, metabolomics, microbiota, microbiome, HPA

Published
2017

14. Private Finance Initiative

Author

McGinty, F., Boomla, Kambiz, Shanmugadasan, Sella, Highton, Clare, Tobias, Gaby, Kohli, Bhupinder, McCloskey, B., and Deakin, M.

Published
2000

23. Forum: Visual Studies—The Art Historians’ View

Author

Morton, M, Maynes, E, McCloskey, B, Hartzell, F, Smith, C, Lübbren, N, Zervigón, AM, Magilow, DH, Weikop, C, Barnstone, DA, Morton, M, Maynes, E, McCloskey, B, Hartzell, F, Smith, C, Lübbren, N, Zervigón, AM, Magilow, DH, Weikop, C, and Barnstone, DA

Published
2019

25. From mass gatherings medicine to mass gatherings health: Conclusions from the 3rd International Conference on Mass Gatherings Medicine, Riyadh, Kingdom of Saudi Arabia

Author

Yezli, S., primary, Assiri, A., additional, Nabulsi, H., additional, Awam, A., additional, Blumberg, L., additional, Endericks, T., additional, Stergachis, A., additional, Reicher, S., additional, McCloskey, B., additional, Petersen, E., additional, and Alotaibi, B., additional

Published
2018
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26. Electrical conductivity in Li2O2 and its role in determining capacity limitations in non-aqueous Li-O2 batteries.

Author

Viswanathan, V., Thygesen, K. S., Hummelsho\j, J. S., No\rskov, J. K., Girishkumar, G., McCloskey, B. D., and Luntz, A. C.

Subjects
ELECTRIC conductivity, METALLIC oxides, LITHIUM-ion batteries, ELECTRIC capacity, CHARGE transfer, ELECTROCHEMISTRY, CRITICAL phenomena (Physics), ELECTROLYTES, INTERFACES (Physical sciences)
Abstract

Non-aqueous Li-air or Li-O2 cells show considerable promise as a very high energy density battery couple. Such cells, however, show sudden death at capacities far below their theoretical capacity and this, among other problems, limits their practicality. In this paper, we show that this sudden death arises from limited charge transport through the growing Li2O2 film to the Li2O2-electrolyte interface, and this limitation defines a critical film thickness, above which it is not possible to support electrochemistry at the Li2O2-electrolyte interface. We report both electrochemical experiments using a reversible internal redox couple and a first principles metal-insulator-metal charge transport model to probe the electrical conductivity through Li2O2 films produced during Li-O2 discharge. Both experiment and theory show a 'sudden death' in charge transport when film thickness is ∼5 to 10 nm. The theoretical model shows that this occurs when the tunneling current through the film can no longer support the electrochemical current. Thus, engineering charge transport through Li2O2 is a serious challenge if Li-O2 batteries are ever to reach their potential. [ABSTRACT FROM AUTHOR]

Published
2011
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27. What is the experience from previous mass gathering events? Lessons for Zika virus and the Olympics 2016

Author

Zumla, A, McCloskey, B, Bin Saeed, AA, Dar, O, Al Otabi, B, Perlmann, S, Gautret, P, Roy, N, Blumberg, L, Azhar, EI, Barbeschi, M, Memish, Z, and Petersen, E

Subjects
virus diseases, human activities, health care economics and organizations
Abstract

All previous experiences from different mass gathering show that vaccine preventable diseases is the most important infections like influemza, hepatitis A, polio and meningitis. Three mass gathering held in Africa during the Ebola outbreak accepted participants from West Africa and was able to handle the theoretical risk without any incident. Therefore we believe that the Olympc games in Rio de Janeiro should not be canceled. The number of visitors to the games is a tine fraction (1%) of other visitors to Zika endemic con tries and it will have no measurable effect on the risk of spreading Zika virus, if the games was cancelled.

Published
2016

29. Free Papers

Author

Girbes, A. R. J., Patten, M. T., McCloskey, B. V., van Twuyver, P., Zwaveling, J. H., Smit, A. J., Buijk, S. L. C. E., Vanden Bergh, M. F. Q., Mouton, J. W., Bruining, H. A., van Vliet, H. J. A., De Marie, S., Page, Y., Viallon, A., Tardy, B., Lafond, P., Gay, J. P., Billard, J. L., Bertrand, J. C., Robert, S., Rouffineau, J., Lecron, J. C., Maillot, N., Mothes, D., Robert, R., Fusciardi, J., Lipman J., Scribante J., Pinder M., Tshukutsoane S., Gous A., Hogendoorn C. Y. A., Klugman K., Young R. J., Lipman J., Gin T., Oh T. E., Gomersall C. D., and Joynt G. M.

Published
1996
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32. Irish cardiac society: Annual general meeting at the Ulster Hospital, Dundonald on December 2nd/3rd, 1983.

Author

Walsh, M. J., Barbir, M., MacMahon, B., Kelly, P., Branagan, J. P., Russell, C., Wilson, C., McCloskey, B., Mathewson, Z., Evuns, A., Chivers, C., Salathia, K. S., Mcllmoyle, E. L., Evans, A., Nicholas, J., Cran, G., Barber, J. M., Shanks, R. G., Elwood, H., Boyle, D. McC, Kenny, J., Smyth, P., Timmis, A., Campbell, S., Monaghan, M., Jewitt, D. E., Evans, A. E., Nicholls, D. P., O’Keeffe, D. B., Morton, P., Murtagh, J. G., Scott, M. E., de Buitleir, M., Rowland, E., Krikler, D. M., Dunn, H. M., McComb, J. M., Campbell, N. P. S., Adgey, A. A. J., Brenan, P., Finn, P. J., Horgan, J. J. H., Quigley, P. J., O’Connor, M. K., Gearty, G., McGovern, E., Corcoran, D., Neligan, M. C., Hamilton, J. R. L., Wood, A. E., O’Kane, H. O. J., Cleland, J., Johnson, H., Awadhi, A. Ai, Conroy, R., Mulcahy, R., Duff, Desmond F., Rudd, Jacqueline, Crean, P. A., Ribeiro, P., Rathcliffe, D., Maseri, A., Gearty, G. F., Maurer, B. J., Scott, M., O’Keeffe, B., Murtagh, G., FitzGerald, G. R., Turner, M., Flanagan, M., Donovan, D., Carvill, P., Delaney, L., Laher, M. S., Darby, S., Finucane, J., Devlin, J. G., Ennis, J., Horgan, J., O’Malley, K., Geddes, J. S., Griffin, B., Blake, S., Neligan, M., Maurer, B., Daly, L., Warren-Smith, Kilcoyne B., and Graham, I.

Published
1984
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33. Private finance scheme for Worcester

Author

McCloskey, B and Taylor, Richard T.

Subjects
Hospitals -- Administration, Health, Hospital/clinic administration software
Abstract

Journal has not presented balanced picture of modern health planning EDITOR--Ferriman's news item on Worcestershire's service reconfiguration[1] failed to reflect a balanced view of the inaccuracies in the report Deficits [...]

Published
2000

34. Syndromic surveillance to assess the potential public health impact of the Icelandic volcanic ash plume across the United Kingdom, April 2010

Author

Aj, Elliot, Singh N, Loveridge P, Harcourt S, Sue Smith, Pnaiser R, Kavanagh K, Robertson C, Cn, Ramsay, McMenamin J, Kibble A, Murray V, Ibbotson S, Catchpole M, McCloskey B, and Ge, Smith

Subjects
Population Surveillance, Epidemiological Monitoring, Iceland, Humans, Disaster Planning, Public Health, Volcanic Eruptions, Respiration Disorders, United Kingdom, Environmental Monitoring
Abstract

The Health Protection Agency and Health Protection Scotland used existing syndromic surveillance systems to monitor community health in the UK following the volcanic eruption in Iceland in April 2010.

Published
2010

40. Using public health scenarios to predict the utility of a national syndromic surveillance programme during the 2012 London Olympic and Paralympic Games

Author

MORBEY, R. A., primary, ELLIOT, A. J., additional, CHARLETT, A., additional, IBBOTSON, S., additional, VERLANDER, N. Q., additional, LEACH, S., additional, HALL, I., additional, BARRASS, I., additional, CATCHPOLE, M., additional, McCLOSKEY, B., additional, SAID, B., additional, WALSH, A., additional, PEBODY, R., additional, and SMITH, G. E., additional

Published
2013
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48. Syndromic surveillance to assess the potential public health impact of the Icelandic volcanic ash plume across the United Kingdom, April 2010

Author

Elliot, A J, primary, Singh, N, additional, Loveridge, P, additional, Harcourt, S, additional, Smith, S, additional, Pnaiser, R, additional, Kavanagh, K, additional, Robertson, C, additional, Ramsay, C N, additional, McMenamin, J, additional, Kibble, A, additional, Murray, V, additional, Ibbotson, S, additional, Catchpole, M, additional, McCloskey, B, additional, and Smith, G E, additional

Published
2010
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