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Your search keyword '"McClenaghan MD"' showing total 5 results
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5 results on '"McClenaghan MD"'

1. Measurement of circulating prostacyclin.

Author

Haslam RJ and McClenaghan MD

Subjects
Adenosine Diphosphate pharmacology, Animals, Epoprostenol pharmacology, Kinetics, Platelet Aggregation drug effects, Prostaglandins E blood, Rabbits, Alprostadil analogs & derivatives, Blood Platelets physiology, Epoprostenol blood, Prostaglandins blood
Published
1981
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2. Cytochalasin B, the blood platelet release reaction and cyclic GMP.

Author

Haslam RJ, Davidson MM, and McClenaghan MD

Subjects
Adenosine Diphosphate pharmacology, Blood Platelets enzymology, Carbon Radioisotopes, Collagen pharmacology, Glucuronidase metabolism, Hexosaminidases metabolism, Humans, Kinetics, L-Lactate Dehydrogenase metabolism, Platelet Aggregation drug effects, Serotonin metabolism, Stimulation, Chemical, Tritium, Blood Platelets metabolism, Cyclic GMP metabolism, Cytochalasin B pharmacology
Published
1975
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3. Factors affecting platelet cyclic GMP levels during aggregation induced by collagen and by arachidonic acid.

Author

Davies T, Davidson MM, McClenaghan MD, Say A, and Haslam RJ

Subjects
Adenosine Diphosphate metabolism, Adenosine Diphosphate pharmacology, Blood Platelets drug effects, Blood Platelets metabolism, Collagen administration & dosage, Dose-Response Relationship, Drug, Guanosine Triphosphate metabolism, Humans, Indomethacin pharmacology, Malondialdehyde biosynthesis, Serotonin metabolism, Serotonin pharmacology, Arachidonic Acids pharmacology, Blood Platelets analysis, Collagen pharmacology, Cyclic GMP analysis, Platelet Aggregation drug effects
Published
1976
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4. Regulation of blood platelet function by cyclic nucleotides.

Author

Haslam RJ, Davidson MM, Davies T, Lynham JA, and McClenaghan MD

Subjects
Adenosine Diphosphate pharmacology, Blood Platelets drug effects, Blood Platelets metabolism, Cyclic AMP blood, Cyclic GMP blood, Deoxyadenosines analogs & derivatives, Deoxyadenosines pharmacology, Humans, In Vitro Techniques, Prostaglandins E pharmacology, Blood Platelets physiology, Cyclic AMP physiology, Cyclic GMP physiology
Published
1978

5. Effects of collagen and of aspirin on the concentration of guanosine 3':5'-cyclic monophosphate in human blood platelets: measurement by a prelabelling technique.

Author

Haslam RJ and McClenaghan MD

Subjects
Blood Platelets drug effects, Chromatography, Thin Layer, Guanine metabolism, Humans, In Vitro Techniques, Platelet Adhesiveness, Time Factors, Tritium, Aspirin pharmacology, Blood Platelets metabolism, Collagen pharmacology, Cyclic GMP blood
Abstract

A method is described for isolating cyclic [(3)H]GMP from platelets preincubated with [(3)H]guanine. Collagen increased and aspirin decreased the cyclic [(3)H]GMP concentration in platelets. The results are consistent with a role for cyclic GMP in the platelet release reaction.

Published
1974
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