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1. Class Dismissed: Quantifying Achievement and the Reinforcement of Inequality

Author

McCleish, Kevin

Abstract

Academic achievement in American high schools is increasingly defined in terms of quantifiable values. Despite being designed to produce favorable data, explicit standardized-test preparation has an insignificant impact on scores and is counterproductive to the cultivation of attributes necessary for success in higher education and effective civic engagement. Reaffirming trends known since the 1970s, standardized test scores directly correlate to socioeconomic status (SES) across time and space, as this study of six Illinois high schools demonstrates. SES functions to engender test scores independent of curriculum decisions and to a higher degree than racial/ethnic demographics alone. Educational inequality cannot be addressed without broader systemic changes to the American political economy. To implement such changes, it is incumbent upon teachers to transcend class-specific curriculums, foster the imagining of different social realities, and develop students' propensity for collective action through critical pedagogy.

Published
2021

3. Supplementary Methods, Figure Legends 1-4 from Evasion Mechanisms to Igf1r Inhibition in Rhabdomyosarcoma

Author

Abraham, Jinu, primary, Prajapati, Suresh I., primary, Nishijo, Koichi, primary, Schaffer, Beverly S., primary, Taniguchi, Eri, primary, Kilcoyne, Aoife, primary, McCleish, Amanda T., primary, Nelon, Laura D., primary, Giles, Francis G., primary, Efstratiadis, Argiris, primary, LeGallo, Robin D., primary, Nowak, Brent M., primary, Rubin, Brian P., primary, Malempati, Suman, primary, and Keller, Charles, primary

Published
2023
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4. Data from Evasion Mechanisms to Igf1r Inhibition in Rhabdomyosarcoma

Author

Abraham, Jinu, primary, Prajapati, Suresh I., primary, Nishijo, Koichi, primary, Schaffer, Beverly S., primary, Taniguchi, Eri, primary, Kilcoyne, Aoife, primary, McCleish, Amanda T., primary, Nelon, Laura D., primary, Giles, Francis G., primary, Efstratiadis, Argiris, primary, LeGallo, Robin D., primary, Nowak, Brent M., primary, Rubin, Brian P., primary, Malempati, Suman, primary, and Keller, Charles, primary

Published
2023
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5. Supplementary Figures 1-4 from Evasion Mechanisms to Igf1r Inhibition in Rhabdomyosarcoma

Author

Abraham, Jinu, primary, Prajapati, Suresh I., primary, Nishijo, Koichi, primary, Schaffer, Beverly S., primary, Taniguchi, Eri, primary, Kilcoyne, Aoife, primary, McCleish, Amanda T., primary, Nelon, Laura D., primary, Giles, Francis G., primary, Efstratiadis, Argiris, primary, LeGallo, Robin D., primary, Nowak, Brent M., primary, Rubin, Brian P., primary, Malempati, Suman, primary, and Keller, Charles, primary

Published
2023
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6. Supplementary Figures 1-4 from Evasion Mechanisms to Igf1r Inhibition in Rhabdomyosarcoma

Author

Charles Keller, Suman Malempati, Brian P. Rubin, Brent M. Nowak, Robin D. LeGallo, Argiris Efstratiadis, Francis G. Giles, Laura D. Nelon, Amanda T. McCleish, Aoife Kilcoyne, Eri Taniguchi, Beverly S. Schaffer, Koichi Nishijo, Suresh I. Prajapati, and Jinu Abraham

Abstract

Supplementary Figures 1-4 from Evasion Mechanisms to Igf1r Inhibition in Rhabdomyosarcoma

Published
2023
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7. Data from Immune Competency of a Hairless Mouse Strain for Improved Preclinical Studies in Genetically Engineered Mice

Author

Schaffer, Beverly S., primary, Grayson, Marcia H., primary, Wortham, Joy M., primary, Kubicek, Courtney B., primary, McCleish, Amanda T., primary, Prajapati, Suresh I., primary, Nelon, Laura D., primary, Brady, Michelle M., primary, Jung, Inkyung, primary, Hosoyama, Tohru, primary, Sarro, Leslea M., primary, Hanes, Martha A., primary, Rubin, Brian P., primary, Michalek, Joel E., primary, Clifford, Charles B., primary, Infante, Anthony J., primary, and Keller, Charles, primary

Published
2023
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8. Supplementary Figure 3 from Immune Competency of a Hairless Mouse Strain for Improved Preclinical Studies in Genetically Engineered Mice

Author

Schaffer, Beverly S., primary, Grayson, Marcia H., primary, Wortham, Joy M., primary, Kubicek, Courtney B., primary, McCleish, Amanda T., primary, Prajapati, Suresh I., primary, Nelon, Laura D., primary, Brady, Michelle M., primary, Jung, Inkyung, primary, Hosoyama, Tohru, primary, Sarro, Leslea M., primary, Hanes, Martha A., primary, Rubin, Brian P., primary, Michalek, Joel E., primary, Clifford, Charles B., primary, Infante, Anthony J., primary, and Keller, Charles, primary

Published
2023
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9. Supplementary Figure 1 from Immune Competency of a Hairless Mouse Strain for Improved Preclinical Studies in Genetically Engineered Mice

Author

Schaffer, Beverly S., primary, Grayson, Marcia H., primary, Wortham, Joy M., primary, Kubicek, Courtney B., primary, McCleish, Amanda T., primary, Prajapati, Suresh I., primary, Nelon, Laura D., primary, Brady, Michelle M., primary, Jung, Inkyung, primary, Hosoyama, Tohru, primary, Sarro, Leslea M., primary, Hanes, Martha A., primary, Rubin, Brian P., primary, Michalek, Joel E., primary, Clifford, Charles B., primary, Infante, Anthony J., primary, and Keller, Charles, primary

Published
2023
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10. Supplementary Figure 2 from Immune Competency of a Hairless Mouse Strain for Improved Preclinical Studies in Genetically Engineered Mice

Author

Schaffer, Beverly S., primary, Grayson, Marcia H., primary, Wortham, Joy M., primary, Kubicek, Courtney B., primary, McCleish, Amanda T., primary, Prajapati, Suresh I., primary, Nelon, Laura D., primary, Brady, Michelle M., primary, Jung, Inkyung, primary, Hosoyama, Tohru, primary, Sarro, Leslea M., primary, Hanes, Martha A., primary, Rubin, Brian P., primary, Michalek, Joel E., primary, Clifford, Charles B., primary, Infante, Anthony J., primary, and Keller, Charles, primary

Published
2023
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11. Supplementary Figure 4 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Nishijo, Koichi, primary, Chen, Qing-Rong, primary, Zhang, Lei, primary, McCleish, Amanda T., primary, Rodriguez, Andrea, primary, Cho, Min Jung, primary, Prajapati, Suresh I., primary, Gelfond, Jonathan A.L., primary, Chisholm, Gary B., primary, Michalek, Joel E., primary, Aronow, Bruce J., primary, Barr, Frederic G., primary, Randall, R. Lor, primary, Ladanyi, Marc, primary, Qualman, Stephen J., primary, Rubin, Brian P., primary, LeGallo, Robin D., primary, Wang, Chiayeng, primary, Khan, Javed, primary, and Keller, Charles, primary

Published
2023
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12. Supplementary Tables 1-7 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Nishijo, Koichi, primary, Chen, Qing-Rong, primary, Zhang, Lei, primary, McCleish, Amanda T., primary, Rodriguez, Andrea, primary, Cho, Min Jung, primary, Prajapati, Suresh I., primary, Gelfond, Jonathan A.L., primary, Chisholm, Gary B., primary, Michalek, Joel E., primary, Aronow, Bruce J., primary, Barr, Frederic G., primary, Randall, R. Lor, primary, Ladanyi, Marc, primary, Qualman, Stephen J., primary, Rubin, Brian P., primary, LeGallo, Robin D., primary, Wang, Chiayeng, primary, Khan, Javed, primary, and Keller, Charles, primary

Published
2023
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13. Supplementary Figure 1 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Nishijo, Koichi, primary, Chen, Qing-Rong, primary, Zhang, Lei, primary, McCleish, Amanda T., primary, Rodriguez, Andrea, primary, Cho, Min Jung, primary, Prajapati, Suresh I., primary, Gelfond, Jonathan A.L., primary, Chisholm, Gary B., primary, Michalek, Joel E., primary, Aronow, Bruce J., primary, Barr, Frederic G., primary, Randall, R. Lor, primary, Ladanyi, Marc, primary, Qualman, Stephen J., primary, Rubin, Brian P., primary, LeGallo, Robin D., primary, Wang, Chiayeng, primary, Khan, Javed, primary, and Keller, Charles, primary

Published
2023
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14. Supplementary Figure 2 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Nishijo, Koichi, primary, Chen, Qing-Rong, primary, Zhang, Lei, primary, McCleish, Amanda T., primary, Rodriguez, Andrea, primary, Cho, Min Jung, primary, Prajapati, Suresh I., primary, Gelfond, Jonathan A.L., primary, Chisholm, Gary B., primary, Michalek, Joel E., primary, Aronow, Bruce J., primary, Barr, Frederic G., primary, Randall, R. Lor, primary, Ladanyi, Marc, primary, Qualman, Stephen J., primary, Rubin, Brian P., primary, LeGallo, Robin D., primary, Wang, Chiayeng, primary, Khan, Javed, primary, and Keller, Charles, primary

Published
2023
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15. Data from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Nishijo, Koichi, primary, Chen, Qing-Rong, primary, Zhang, Lei, primary, McCleish, Amanda T., primary, Rodriguez, Andrea, primary, Cho, Min Jung, primary, Prajapati, Suresh I., primary, Gelfond, Jonathan A.L., primary, Chisholm, Gary B., primary, Michalek, Joel E., primary, Aronow, Bruce J., primary, Barr, Frederic G., primary, Randall, R. Lor, primary, Ladanyi, Marc, primary, Qualman, Stephen J., primary, Rubin, Brian P., primary, LeGallo, Robin D., primary, Wang, Chiayeng, primary, Khan, Javed, primary, and Keller, Charles, primary

Published
2023
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16. Supplementary Table 8 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Nishijo, Koichi, primary, Chen, Qing-Rong, primary, Zhang, Lei, primary, McCleish, Amanda T., primary, Rodriguez, Andrea, primary, Cho, Min Jung, primary, Prajapati, Suresh I., primary, Gelfond, Jonathan A.L., primary, Chisholm, Gary B., primary, Michalek, Joel E., primary, Aronow, Bruce J., primary, Barr, Frederic G., primary, Randall, R. Lor, primary, Ladanyi, Marc, primary, Qualman, Stephen J., primary, Rubin, Brian P., primary, LeGallo, Robin D., primary, Wang, Chiayeng, primary, Khan, Javed, primary, and Keller, Charles, primary

Published
2023
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17. Supplementary Figure Legends 1-5 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Nishijo, Koichi, primary, Chen, Qing-Rong, primary, Zhang, Lei, primary, McCleish, Amanda T., primary, Rodriguez, Andrea, primary, Cho, Min Jung, primary, Prajapati, Suresh I., primary, Gelfond, Jonathan A.L., primary, Chisholm, Gary B., primary, Michalek, Joel E., primary, Aronow, Bruce J., primary, Barr, Frederic G., primary, Randall, R. Lor, primary, Ladanyi, Marc, primary, Qualman, Stephen J., primary, Rubin, Brian P., primary, LeGallo, Robin D., primary, Wang, Chiayeng, primary, Khan, Javed, primary, and Keller, Charles, primary

Published
2023
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18. Supplementary Table 10 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Nishijo, Koichi, primary, Chen, Qing-Rong, primary, Zhang, Lei, primary, McCleish, Amanda T., primary, Rodriguez, Andrea, primary, Cho, Min Jung, primary, Prajapati, Suresh I., primary, Gelfond, Jonathan A.L., primary, Chisholm, Gary B., primary, Michalek, Joel E., primary, Aronow, Bruce J., primary, Barr, Frederic G., primary, Randall, R. Lor, primary, Ladanyi, Marc, primary, Qualman, Stephen J., primary, Rubin, Brian P., primary, LeGallo, Robin D., primary, Wang, Chiayeng, primary, Khan, Javed, primary, and Keller, Charles, primary

Published
2023
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19. Supplementary Figure 3 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Nishijo, Koichi, primary, Chen, Qing-Rong, primary, Zhang, Lei, primary, McCleish, Amanda T., primary, Rodriguez, Andrea, primary, Cho, Min Jung, primary, Prajapati, Suresh I., primary, Gelfond, Jonathan A.L., primary, Chisholm, Gary B., primary, Michalek, Joel E., primary, Aronow, Bruce J., primary, Barr, Frederic G., primary, Randall, R. Lor, primary, Ladanyi, Marc, primary, Qualman, Stephen J., primary, Rubin, Brian P., primary, LeGallo, Robin D., primary, Wang, Chiayeng, primary, Khan, Javed, primary, and Keller, Charles, primary

Published
2023
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20. Supplementary Table 9 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Nishijo, Koichi, primary, Chen, Qing-Rong, primary, Zhang, Lei, primary, McCleish, Amanda T., primary, Rodriguez, Andrea, primary, Cho, Min Jung, primary, Prajapati, Suresh I., primary, Gelfond, Jonathan A.L., primary, Chisholm, Gary B., primary, Michalek, Joel E., primary, Aronow, Bruce J., primary, Barr, Frederic G., primary, Randall, R. Lor, primary, Ladanyi, Marc, primary, Qualman, Stephen J., primary, Rubin, Brian P., primary, LeGallo, Robin D., primary, Wang, Chiayeng, primary, Khan, Javed, primary, and Keller, Charles, primary

Published
2023
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21. Supplementary Methods and Materials from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Nishijo, Koichi, primary, Chen, Qing-Rong, primary, Zhang, Lei, primary, McCleish, Amanda T., primary, Rodriguez, Andrea, primary, Cho, Min Jung, primary, Prajapati, Suresh I., primary, Gelfond, Jonathan A.L., primary, Chisholm, Gary B., primary, Michalek, Joel E., primary, Aronow, Bruce J., primary, Barr, Frederic G., primary, Randall, R. Lor, primary, Ladanyi, Marc, primary, Qualman, Stephen J., primary, Rubin, Brian P., primary, LeGallo, Robin D., primary, Wang, Chiayeng, primary, Khan, Javed, primary, and Keller, Charles, primary

Published
2023
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22. Supplementary Figure 5 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Nishijo, Koichi, primary, Chen, Qing-Rong, primary, Zhang, Lei, primary, McCleish, Amanda T., primary, Rodriguez, Andrea, primary, Cho, Min Jung, primary, Prajapati, Suresh I., primary, Gelfond, Jonathan A.L., primary, Chisholm, Gary B., primary, Michalek, Joel E., primary, Aronow, Bruce J., primary, Barr, Frederic G., primary, Randall, R. Lor, primary, Ladanyi, Marc, primary, Qualman, Stephen J., primary, Rubin, Brian P., primary, LeGallo, Robin D., primary, Wang, Chiayeng, primary, Khan, Javed, primary, and Keller, Charles, primary

Published
2023
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23. Supplementary Figure 3 from Immune Competency of a Hairless Mouse Strain for Improved Preclinical Studies in Genetically Engineered Mice

Author

Charles Keller, Anthony J. Infante, Charles B. Clifford, Joel E. Michalek, Brian P. Rubin, Martha A. Hanes, Leslea M. Sarro, Tohru Hosoyama, Inkyung Jung, Michelle M. Brady, Laura D. Nelon, Suresh I. Prajapati, Amanda T. McCleish, Courtney B. Kubicek, Joy M. Wortham, Marcia H. Grayson, and Beverly S. Schaffer

Abstract

Supplementary Figure 3 from Immune Competency of a Hairless Mouse Strain for Improved Preclinical Studies in Genetically Engineered Mice

Published
2023
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24. Supplementary Figure 1 from Immune Competency of a Hairless Mouse Strain for Improved Preclinical Studies in Genetically Engineered Mice

Author

Charles Keller, Anthony J. Infante, Charles B. Clifford, Joel E. Michalek, Brian P. Rubin, Martha A. Hanes, Leslea M. Sarro, Tohru Hosoyama, Inkyung Jung, Michelle M. Brady, Laura D. Nelon, Suresh I. Prajapati, Amanda T. McCleish, Courtney B. Kubicek, Joy M. Wortham, Marcia H. Grayson, and Beverly S. Schaffer

Abstract

Supplementary Figure 1 from Immune Competency of a Hairless Mouse Strain for Improved Preclinical Studies in Genetically Engineered Mice

Published
2023
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25. Supplementary Figure 2 from Immune Competency of a Hairless Mouse Strain for Improved Preclinical Studies in Genetically Engineered Mice

Author

Charles Keller, Anthony J. Infante, Charles B. Clifford, Joel E. Michalek, Brian P. Rubin, Martha A. Hanes, Leslea M. Sarro, Tohru Hosoyama, Inkyung Jung, Michelle M. Brady, Laura D. Nelon, Suresh I. Prajapati, Amanda T. McCleish, Courtney B. Kubicek, Joy M. Wortham, Marcia H. Grayson, and Beverly S. Schaffer

Abstract

Supplementary Figure 2 from Immune Competency of a Hairless Mouse Strain for Improved Preclinical Studies in Genetically Engineered Mice

Published
2023
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26. Data from Immune Competency of a Hairless Mouse Strain for Improved Preclinical Studies in Genetically Engineered Mice

Author

Charles Keller, Anthony J. Infante, Charles B. Clifford, Joel E. Michalek, Brian P. Rubin, Martha A. Hanes, Leslea M. Sarro, Tohru Hosoyama, Inkyung Jung, Michelle M. Brady, Laura D. Nelon, Suresh I. Prajapati, Amanda T. McCleish, Courtney B. Kubicek, Joy M. Wortham, Marcia H. Grayson, and Beverly S. Schaffer

Abstract

Genetically engineered mouse models (GEMM) of cancer are of increasing value to preclinical therapeutics. Optical imaging is a cost-effective method of assessing deep-seated tumor growth in GEMMs whose tumors can be encoded to express luminescent or fluorescent reporters, although reporter signal attenuation would be improved if animals were fur-free. In this study, we sought to determine whether hereditable furlessness resulting from a hypomorphic mutation in the Hairless gene would or would not also affect immune competence. By assessing humoral and cellular immunity of the SKH1 mouse line bearing the hypomorphic Hairless mutation, we determined that blood counts, immunoglobulin levels, and CD4+ and CD8+ T cells were comparable between SKH1 and the C57Bl/6 strain. On examination of T-cell subsets, statistically significant differences in naïve T cells (1.7 versus 3.4 × 105 cells/spleen in SKH1 versus C57Bl/6, P = 0.008) and memory T cells (1.4 versus 0.13 × 106 cells/spleen in SKH1 versus C57Bl/6, P = 0.008) were detected. However, the numerical differences did not result in altered T-cell functional response to antigen rechallenge (keyhole limpet hemocyanin) in a lymph node cell in vitro proliferative assay. Furthermore, interbreeding the SKH1 mouse line to a rhabdomyosarcoma GEMM showed preserved antitumor responses of CD56+ natural killer cells and CD163+ macrophages, without any differences in tumor pathology. The fur-free GEMM was also especially amenable to multiplex optical imaging. Thus, SKH1 represents an immune competent, fur-free mouse strain that may be of use for interbreeding to other genetically engineered mouse models of cancer for improved preclinical studies. Mol Cancer Ther; 9(8); 2354–64. ©2010 AACR.

Published
2023
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27. Supplementary Figure 1 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Charles Keller, Javed Khan, Chiayeng Wang, Robin D. LeGallo, Brian P. Rubin, Stephen J. Qualman, Marc Ladanyi, R. Lor Randall, Frederic G. Barr, Bruce J. Aronow, Joel E. Michalek, Gary B. Chisholm, Jonathan A.L. Gelfond, Suresh I. Prajapati, Min Jung Cho, Andrea Rodriguez, Amanda T. McCleish, Lei Zhang, Qing-Rong Chen, and Koichi Nishijo

Abstract

Supplementary Figure 1 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Published
2023
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28. Supplementary Table 10 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Charles Keller, Javed Khan, Chiayeng Wang, Robin D. LeGallo, Brian P. Rubin, Stephen J. Qualman, Marc Ladanyi, R. Lor Randall, Frederic G. Barr, Bruce J. Aronow, Joel E. Michalek, Gary B. Chisholm, Jonathan A.L. Gelfond, Suresh I. Prajapati, Min Jung Cho, Andrea Rodriguez, Amanda T. McCleish, Lei Zhang, Qing-Rong Chen, and Koichi Nishijo

Abstract

Supplementary Table 10 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Published
2023
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29. Data from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Charles Keller, Javed Khan, Chiayeng Wang, Robin D. LeGallo, Brian P. Rubin, Stephen J. Qualman, Marc Ladanyi, R. Lor Randall, Frederic G. Barr, Bruce J. Aronow, Joel E. Michalek, Gary B. Chisholm, Jonathan A.L. Gelfond, Suresh I. Prajapati, Min Jung Cho, Andrea Rodriguez, Amanda T. McCleish, Lei Zhang, Qing-Rong Chen, and Koichi Nishijo

Abstract

The highly aggressive muscle cancer alveolar rhabdomyosarcoma (ARMS) is one of the most common soft tissue sarcoma of childhood, yet the outcome for the unresectable and metastatic disease is dismal and unchanged for nearly three decades. To better understand the pathogenesis of this disease and to facilitate novel preclinical approaches, we previously developed a conditional mouse model of ARMS by faithfully recapitulating the genetic mutations observed in the human disease, i.e., activation of Pax3:Fkhr fusion gene with either p53 or Cdkn2a inactivation. In this report, we show that this model recapitulates the immunohistochemical profile and the rapid progression of the human disease. We show that Pax3:Fkhr expression increases during late preneoplasia but tumor cells undergoing metastasis are under apparent selection for Pax3:Fkhr expression. At a whole-genome level, a cross-species gene set enrichment analysis and metagene projection study showed that our mouse model is most similar to human ARMS when compared with other pediatric cancers. We have defined an expression profile conserved between mouse and human ARMS, as well as a Pax3:Fkhr signature, including the target gene, SKP2. We further identified 7 “druggable” kinases overexpressed across species. The data affirm the accuracy of this genetically engineered mouse model. [Cancer Res 2009;69(7):2902–11]

Published
2023
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30. Supplementary Figure 2 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Charles Keller, Javed Khan, Chiayeng Wang, Robin D. LeGallo, Brian P. Rubin, Stephen J. Qualman, Marc Ladanyi, R. Lor Randall, Frederic G. Barr, Bruce J. Aronow, Joel E. Michalek, Gary B. Chisholm, Jonathan A.L. Gelfond, Suresh I. Prajapati, Min Jung Cho, Andrea Rodriguez, Amanda T. McCleish, Lei Zhang, Qing-Rong Chen, and Koichi Nishijo

Abstract

Supplementary Figure 2 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Published
2023
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31. Supplementary Methods and Materials from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Charles Keller, Javed Khan, Chiayeng Wang, Robin D. LeGallo, Brian P. Rubin, Stephen J. Qualman, Marc Ladanyi, R. Lor Randall, Frederic G. Barr, Bruce J. Aronow, Joel E. Michalek, Gary B. Chisholm, Jonathan A.L. Gelfond, Suresh I. Prajapati, Min Jung Cho, Andrea Rodriguez, Amanda T. McCleish, Lei Zhang, Qing-Rong Chen, and Koichi Nishijo

Abstract

Supplementary Methods and Materials from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Published
2023
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32. Supplementary Figure 5 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Charles Keller, Javed Khan, Chiayeng Wang, Robin D. LeGallo, Brian P. Rubin, Stephen J. Qualman, Marc Ladanyi, R. Lor Randall, Frederic G. Barr, Bruce J. Aronow, Joel E. Michalek, Gary B. Chisholm, Jonathan A.L. Gelfond, Suresh I. Prajapati, Min Jung Cho, Andrea Rodriguez, Amanda T. McCleish, Lei Zhang, Qing-Rong Chen, and Koichi Nishijo

Abstract

Supplementary Figure 5 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Published
2023
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33. Supplementary Tables 1-7 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Charles Keller, Javed Khan, Chiayeng Wang, Robin D. LeGallo, Brian P. Rubin, Stephen J. Qualman, Marc Ladanyi, R. Lor Randall, Frederic G. Barr, Bruce J. Aronow, Joel E. Michalek, Gary B. Chisholm, Jonathan A.L. Gelfond, Suresh I. Prajapati, Min Jung Cho, Andrea Rodriguez, Amanda T. McCleish, Lei Zhang, Qing-Rong Chen, and Koichi Nishijo

Abstract

Supplementary Tables 1-7 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Published
2023
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34. Supplementary Figure 3 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Charles Keller, Javed Khan, Chiayeng Wang, Robin D. LeGallo, Brian P. Rubin, Stephen J. Qualman, Marc Ladanyi, R. Lor Randall, Frederic G. Barr, Bruce J. Aronow, Joel E. Michalek, Gary B. Chisholm, Jonathan A.L. Gelfond, Suresh I. Prajapati, Min Jung Cho, Andrea Rodriguez, Amanda T. McCleish, Lei Zhang, Qing-Rong Chen, and Koichi Nishijo

Abstract

Supplementary Figure 3 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Published
2023
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35. Supplementary Table 8 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Charles Keller, Javed Khan, Chiayeng Wang, Robin D. LeGallo, Brian P. Rubin, Stephen J. Qualman, Marc Ladanyi, R. Lor Randall, Frederic G. Barr, Bruce J. Aronow, Joel E. Michalek, Gary B. Chisholm, Jonathan A.L. Gelfond, Suresh I. Prajapati, Min Jung Cho, Andrea Rodriguez, Amanda T. McCleish, Lei Zhang, Qing-Rong Chen, and Koichi Nishijo

Abstract

Supplementary Table 8 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Published
2023
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36. Supplementary Table 9 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Charles Keller, Javed Khan, Chiayeng Wang, Robin D. LeGallo, Brian P. Rubin, Stephen J. Qualman, Marc Ladanyi, R. Lor Randall, Frederic G. Barr, Bruce J. Aronow, Joel E. Michalek, Gary B. Chisholm, Jonathan A.L. Gelfond, Suresh I. Prajapati, Min Jung Cho, Andrea Rodriguez, Amanda T. McCleish, Lei Zhang, Qing-Rong Chen, and Koichi Nishijo

Abstract

Supplementary Table 9 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Published
2023
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37. Supplementary Figure 4 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Charles Keller, Javed Khan, Chiayeng Wang, Robin D. LeGallo, Brian P. Rubin, Stephen J. Qualman, Marc Ladanyi, R. Lor Randall, Frederic G. Barr, Bruce J. Aronow, Joel E. Michalek, Gary B. Chisholm, Jonathan A.L. Gelfond, Suresh I. Prajapati, Min Jung Cho, Andrea Rodriguez, Amanda T. McCleish, Lei Zhang, Qing-Rong Chen, and Koichi Nishijo

Abstract

Supplementary Figure 4 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Published
2023
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38. Supplementary Figure Legends 1-5 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Author

Charles Keller, Javed Khan, Chiayeng Wang, Robin D. LeGallo, Brian P. Rubin, Stephen J. Qualman, Marc Ladanyi, R. Lor Randall, Frederic G. Barr, Bruce J. Aronow, Joel E. Michalek, Gary B. Chisholm, Jonathan A.L. Gelfond, Suresh I. Prajapati, Min Jung Cho, Andrea Rodriguez, Amanda T. McCleish, Lei Zhang, Qing-Rong Chen, and Koichi Nishijo

Abstract

Supplementary Figure Legends 1-5 from Credentialing a Preclinical Mouse Model of Alveolar Rhabdomyosarcoma

Published
2023
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39. Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma

Author

Rubin, Brian P., Nishijo, Koichi, Chen, Hung-I Harry, Yi, Xiaolan, Schuetze, David P., Pal, Ranadip, Prajapati, Suresh I., Abraham, Jinu, Arenkiel, Benjamin R., Chen, Qing-Rong, Davis, Sean, McCleish, Amanda T., Capecchi, Mario R., Michalek, Joel E., Zarzabal, Lee Ann, Khan, Javed, Yu, Zhongxin, Parham, David M., Barr, Frederic G., Meltzer, Paul S., Chen, Yidong, and Keller, Charles

Published
2011
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44. CENTRIC: BLEEDING PROCEDURE FOR CLUTCH HYDRAULIC SYSTEMS WITH NO BLEEDER VALVES

Author

McCleish, Patrick

Subjects
Valves, Industrial equipment, Plastic products, Automobile industry, Business
Abstract

Many modern clutch hydraulic systems are not equipped with bleeder valves on either the master cylinder or the slave cylinder. Use this procedure to bleed these types of systems when [...]

Published
2019

48. Examination of the effects of external load, velocity, and center of gravity on weight estimation using a lifting linkage

Author

Ryan McCleish

Subjects
Engineering, Constant of motion, Payload, business.industry, System of measurement, Linkage (mechanical), Four-bar linkage, Pressure sensor, law.invention, Center of gravity, Weight estimation, law, Control theory, business
Abstract

Having an accurate measurement of the weight of a vehicle payload is important, when moving material. An accurate knowledge of the payload can increase efficiency during material transportation, by ensuring the maximum payload is being moved. Many existing weight measurement systems exist but are often costly, add significant weight, or increase operating time. An improved dynamic weight measurement system to estimate the weight of a payload inside of a container is proposed in this research. Using pressure transducers and angle sensors on a lifting linkage, the weight of a payload is calculated in constant motion, which minimizes any time loss due to measurements. A math model was developed, and the results were simulated to determine the major contributing factors that affect the pressure. An experimental setup was used to test the effects that pressure has on three variables: velocity, center of gravity, and weight. The results showed that each of the experimental variables could be independently varied and had an effect on the cylinder pressure.

Published
2018
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49. Differences in Two- and Three-Dimensional Assessment of the Mitral Valve by Novices and Experts, Illustrated Using Anterior Mitral Valve Leaflet Length

Author

Frederick C. Cobey, Patrick Wouters, Eckhard Mauermann, G. Burkhard Mackensen, Stefaan Bouchez, Madhav Swaminathan, and Linda McCleish

Subjects
Male, medicine.medical_specialty, Validation study, Interobserver reliability, Echocardiography, Three-Dimensional, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, Mitral valve, Internal medicine, Medicine, Humans, cardiovascular diseases, Longitudinal axis, Expert Testimony, Aged, Retrospective Studies, Mitral regurgitation, business.industry, Mitral Valve Insufficiency, Middle Aged, University hospital, Cardiac surgery, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Echocardiography, cardiovascular system, Cardiology, Mitral Valve, Female, Clinical Competence, Cardiology and Cardiovascular Medicine, business, human activities, Mitral valve leaflet
Abstract

In this measurement validation study, the authors evaluated agreement between 2-dimensional (2D) and three-dimensional (3D) transesophageal echocardiography (TEE), measuring anterior mitral valve leaflet length by both novice and experienced echocardiographers.This was a retrospective, observational study.Single university hospital.Analyses on datasets from 44 patients.None.Fifty datasets from 44 patients with mitral regurgitation were analyzed by 4 observers (2 novices, 2 experts). All observers measured the anterior mitral valve leaflet length from end-systolic 2D TEE images from the midesophageal longitudinal axis view and 3D software-augmented TEE images. The overall mean anterior mitral valve leaflet length was significantly shorter with 3D versus 2D TEE measurements (24.6 ± 4.5 mm v 26.2 ± 5.3 mm; p0.001), with novices measuring shorter leaflets than experts for both techniques (p0.001 and p = 0.005, respectively). Bland-Altman plots of 3D and 2D TEE measurements showed mean biases (95% limits of agreement) of -1.6 mm (-9.0 to 5.9 mm), -1.8 mm (-9.6 to 6.0 mm), and -1.3 mm (-8.4 to 5.7 mm) for all observers, novices, and experts, respectively. For 2D measurements, interobserver reliability was very strong among experts and strong among novices (Pearson's r = 0.83 v 0.66; p = 0.055). For 3D measurements, interobserver reliability was strong in experts and moderate in novices (Pearson's r = 0.69 v 0.51; p = 0.168).For both novices and experts, 3D TEE measurements of the anterior mitral valve leaflet were significantly shorter than 2D measurements. Interobserver reliability was lowest for novices making 3D TEE measurements, indicating that reliable, quantitative evaluation of 3D TEE may require a greater amount of practice.

Published
2018

50. Lineage of origin in rhabdomyosarcoma informs pharmacological response

Author

Simone Hettmer, Paul S. Meltzer, Benjamin Ehler, Lee Ann Zarzabal, Yaiza Núñez-Álvarez, Sheila T. Hampton, Elvira Carrió, Sean Davis, Mario R. Capecchi, Elaine T. Huang, Hung I Harry Chen, Charles Keller, Joel E. Michalek, Frank C. Marini, Amanda T. McCleish, Robin D. LeGallo, Robert L. Walker, Brian P. Rubin, Yi Chen, Jennifer Rebeles, Thomas A. Rando, Jinu Abraham, Amy J. Wagers, Suresh I. Prajapati, Martin Goros, Atiya Mansoor, Andrew S. Brack, Mònica Suelves, Christopher R. R. Bjornson, Hunter Wiebush, Koichi Nishijo, and David M. Langenau

Subjects
Pyridines, medicine.drug_class, Cell of origin, PAX3, Antineoplastic Agents, FOXO1, Biology, Epigenesis, Genetic, Mice, chemistry.chemical_compound, Cell Line, Tumor, Genetics, medicine, Transcriptional regulation, Animals, Humans, Paired Box Transcription Factors, Cell Lineage, Rhabdomyosarcoma, PAX3 Transcription Factor, Rhabdomyosarcoma, Alveolar, Forkhead Box Protein O1, Entinostat, Histone deacetylase inhibitor, Forkhead Transcription Factors, medicine.disease, Gene Expression Regulation, Neoplastic, Disease Models, Animal, chemistry, Benzamides, Cancer research, Alveolar rhabdomyosarcoma, Tumor Suppressor Protein p53, Research Paper, Developmental Biology
Abstract

Lineage or cell of origin of cancers is often unknown and thus is not a consideration in therapeutic approaches. Alveolar rhabdomyosarcoma (aRMS) is an aggressive childhood cancer for which the cell of origin remains debated. We used conditional genetic mouse models of aRMS to activate the pathognomonic Pax3:Foxo1 fusion oncogene and inactivate p53 in several stages of prenatal and postnatal muscle development. We reveal that lineage of origin significantly influences tumor histomorphology and sensitivity to targeted therapeutics. Furthermore, we uncovered differential transcriptional regulation of the Pax3:Foxo1 locus by tumor lineage of origin, which led us to identify the histone deacetylase inhibitor entinostat as a pharmacological agent for the potential conversion of Pax3:Foxo1-positive aRMS to a state akin to fusion-negative RMS through direct transcriptional suppression of Pax3:Foxo1.

Published
2014
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