653 results on '"McCarthy, William J."'
Search Results
2. Randomized Comparative Effectiveness Trial of 2 Federally Recommended Strategies to Reduce Excess Body Fat in Overweight, Low-Income Patients: MyPlate.gov vs Calorie Counting
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McCarthy, William J, Rico, Melvin, Chandler, Maria, Herman, Dena R, Chang, Cindy, Belin, Thomas R, Love, Stephanie, Ramirez, Evangelina, and Gelberg, Lillian
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Biomedical and Clinical Sciences ,Health Services and Systems ,Public Health ,Health Sciences ,Nutrition and Dietetics ,Clinical Trials and Supportive Activities ,Comparative Effectiveness Research ,Nutrition ,Patient Safety ,Clinical Research ,Behavioral and Social Science ,Obesity ,Prevention ,Diabetes ,Health Services ,Prevention of disease and conditions ,and promotion of well-being ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,Metabolic and endocrine ,Cardiovascular ,Stroke ,Oral and gastrointestinal ,Cancer ,Quality Education ,Adult ,Humans ,Overweight ,Quality of Life ,Adipose Tissue ,Poverty ,clinical trial ,obesity treatment ,nutrition intervention ,Latine ,immigrant ,Medical and Health Sciences ,Studies in Human Society ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences ,Human society - Abstract
PurposeSince 2011, US authorities have supported the following 2 approaches to healthier body fat composition: the Centers for Disease Control and Prevention National Diabetes Prevention Program's calorie counting (CC) approach and the US Department of Agriculture's MyPlate (adherence to federal nutrition guidelines). The purpose of this study was to compare the effect of CC vs MyPlate approaches on satiety/satiation and on achieving healthier body fat composition among primary care patients.MethodsWe conducted a randomized controlled trial comparing the CC and MyPlate approaches from 2015 to 2017. The adult participants were overweight, of low income, and were mostly Latine (n = 261). For both approaches, community health workers conducted 2 home education visits, 2 group education sessions, and 7 telephone coaching calls over a period of 6 months. Satiation and satiety were the primary patient-centered outcome measures. Waist circumference and body weight were the primary anthropometric measures. Measures were assessed at baseline, 6 months, and 12 months.ResultsSatiation and satiety scores increased for both groups. Waist circumference was significantly decreased in both groups. MyPlate, but not CC, resulted in lower systolic blood pressure at 6 months but not at 12 months. Participants for both MyPlate and CC reported greater quality of life and emotional well-being and high satisfaction with their assigned weight-loss program. The most acculturated participants showed the greatest decreases in waist circumference.ConclusionsA MyPlate-based intervention might be a practical alternative to the more traditional CC approach to promoting satiety and facilitating decreases in central adiposity among low-income, mostly Latine primary care patients.
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- 2023
3. Undergraduate support for university smoke-free and vape-free campus policies and student engagement: a quasi-experimental intervention
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Cheung, Elaine, Romero, Tamineh, Crespi, Catherine M, Perez, Claudia, Huang, Janice E, Pechmann, Cornelia, and McCarthy, William J
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Public Health ,Health Sciences ,Tobacco ,Prevention ,Tobacco Smoke and Health ,Clinical Research ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,Prevention of disease and conditions ,and promotion of well-being ,Stroke ,Respiratory ,Quality Education ,Good Health and Well Being ,Electronic Nicotine Delivery Systems ,Humans ,Smoke-Free Policy ,Students ,Universities ,Vaping ,College ,public policy ,smoke-free ,vape-free ,social marketing ,tobacco-control ,smoke-free/vape-free ,Public Health and Health Services ,Substance Abuse ,Clinical sciences ,Public health - Abstract
BackgroundCollege campuses have policies restricting smoking/vaping on campus. Previous studies involving mostly European-American students showed smoking prevalence declines following implementation of such policies.ObjectiveTo evaluate a social media campaign promotive of stronger campus support for an existing campus no-smoking/no-vaping policy where most (∼75%) of the undergraduates were non-European-American. A demographically comparable university served as a no-intervention control.ParticipantsTarget was 200 random intercept surveys at each university during fall 2016, spring 2017. Of 800 respondents, 681 were undergraduates.MethodsBaseline and post-intervention surveys assessed awareness of and support for campus-wide smoke-free/vape-free policies. Staged smoke-free/vape-free policy violations assessed students' propensity to intervene in support of the policy.ResultsRespondent support for the no-smoking/no-vaping policy did not change.ConclusionsThe social media campaign and Policy Ambassadors program did not increase support for the campus no-smoking/no-vaping policy. Most (∼90%) respondents agreed that the campus no-smoking/no-vaping policy was important for public health.
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- 2022
4. Covalent fragment-based drug discovery for target tractability
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McCarthy, William J., van der Zouwen, Antonie J., Bush, Jacob T., and Rittinger, Katrin
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- 2024
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5. “Ancestral recipes”: a mixed-methods analysis of MyPlate-based recipe dissemination for Latinos in rural communities
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Cheney, Ann Marie, McCarthy, William J., Pozar, María, Reaves, Christina, Ortiz, Gabriela, Lopez, Diana, Saldivar, Perla A., and Gelberg, Lillian
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- 2023
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6. A statewide study of disparities in local policies and tobacco, vape, and cannabis retail environments
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Bostean, Georgiana, Ponicki, William R., Padon, Alisa A., McCarthy, William J., and Unger, Jennifer B.
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- 2023
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7. Undergraduate Support for University Smoke-Free and Vape-Free Campus Policies and Student Engagement: A Quasi-Experimental Intervention
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Cheung, Elaine, Romero, Tamineh, Crespi, Catherine M., Perez, Claudia, Huang, Janice E., Pechmann, Cornelia, and McCarthy, William J.
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Background: College campuses have policies restricting smoking/vaping on campus. Previous studies involving mostly European-American students showed smoking prevalence declines following implementation of such policies. Objective: To evaluate a social media campaign promotive of stronger campus support for an existing campus no-smoking/no-vaping policy where most ([approximately]75%) of the undergraduates were non-European-American. A demographically comparable university served as a no-intervention control. Participants: Target was 200 random intercept surveys at each university during fall 2016, spring 2017. Of 800 respondents, 681 were undergraduates. Methods: Baseline and post-intervention surveys assessed awareness of and support for campus-wide smoke-free/vape-free policies. Staged smoke-free/vape-free policy violations assessed students' propensity to intervene in support of the policy. Results: Respondent support for the no-smoking/no-vaping policy did not change. Conclusions: The social media campaign and Policy Ambassadors program did not increase support for the campus no-smoking/no-vaping policy. Most ([approximately]90%) respondents agreed that the campus no-smoking/no-vaping policy was important for public health.
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- 2022
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8. Undergraduate support for university smoke-free and vape-free campus policies and student engagement: a quasi-experimental intervention.
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Cheung, Elaine, Romero, Tamineh, Crespi, Catherine M, Perez, Claudia, Huang, Janice E, Pechmann, Cornelia, and McCarthy, William J
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College ,public policy ,smoke-free/vape-free ,social marketing ,tobacco-control ,Public Health and Health Services ,Substance Abuse - Abstract
Background: College campuses have policies restricting smoking/vaping on campus. Previous studies involving mostly European-American students showed smoking prevalence declines following implementation of such policies.Objective: To evaluate a social media campaign promotive of stronger campus support for an existing campus no-smoking/no-vaping policy where most (∼75%) of the undergraduates were non-European-American. A demographically comparable university served as a no-intervention control.Participants: Target was 200 random intercept surveys at each university during fall 2016, spring 2017. Of 800 respondents, 681 were undergraduates.Methods: Baseline and post-intervention surveys assessed awareness of and support for campus-wide smoke-free/vape-free policies. Staged smoke-free/vape-free policy violations assessed students' propensity to intervene in support of the policy.Results: Respondent support for the no-smoking/no-vaping policy did not change.Conclusions: The social media campaign and Policy Ambassadors program did not increase support for the campus no-smoking/no-vaping policy. Most (∼90%) respondents agreed that the campus no-smoking/no-vaping policy was important for public health.
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- 2020
9. Risk of developing pre-diabetes or diabetes over time in a cohort of Mexican health workers
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Flores, Yvonne N, Toth, Samantha, Crespi, Catherine M, Ramírez-Palacios, Paula, McCarthy, William J, Briseño-Pérez, Arely, Granados-García, Víctor, and Salmerón, Jorge
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Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Obesity ,Prevention ,Nutrition ,Diabetes ,Clinical Research ,Metabolic and endocrine ,Stroke ,Adult ,Body Mass Index ,Cross-Sectional Studies ,Diabetes Mellitus ,Female ,Health Workforce ,Humans ,Longitudinal Studies ,Male ,Metabolic Syndrome ,Mexico ,Middle Aged ,Overweight ,Prediabetic State ,Prevalence ,Risk Factors ,General Science & Technology - Abstract
AimTo determine the association between known risk factors (e.g., obesity, metabolic syndrome and its components) and the development of pre-diabetes or diabetes over time in a cohort of Mexican health workers.MethodsParticipants in the Mexican Health Worker Cohort Study with complete information at two waves of data collection, 2004-2006 (W1) and 2011-2013 (W2), were included in the analysis (n = 1,174). Multivariable binary and multinomial logistic regression were used to examine the cross-sectional associations between specific risk factors and diabetes status (diabetes, pre-diabetes, or neither) at W1 and the longitudinal associations between changes in risk factors and progression of diabetes status from W1 to W2, respectively.ResultsMean time between waves was 7.0 years (SD 1.1). Prevalence of pre-diabetes and diabetes was 16% and 10% at W1 and increased to 30% and 16% at W2, respectively. The cross-sectional prevalence of pre-diabetes and diabetes was significantly higher among men, participants over the age of 45 years, and individuals who were overweight or obese or had metabolic syndrome (MS), three or more components of the MS, elevated alanine aminotransferase (ALT) levels, or elevated uric acid. In longitudinal analyses, remaining obese or gaining weight between waves was associated with an increased risk of developing pre-diabetes. A greater risk of developing pre-diabetes or diabetes was also observed among individuals who either maintained or acquired MS, elevated ALT, or elevated uric acid (only for diabetes) from W1 to W2.ConclusionsWeight gain and acquiring or maintaining MS, elevated ALT levels, or elevated uric acid were associated with a significant risk of developing pre-diabetes or diabetes. Our findings, especially in the context of the obesity epidemic in Mexico, point towards an urgent need for initiatives to help reduce excess weight in order to avert future cases of pre-diabetes and diabetes.
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- 2020
10. Comparative effectiveness trial comparing MyPlate to calorie counting for mostly low-income Latino primary care patients of a federally qualified community health center: study design, baseline characteristics
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Gelberg, Lillian, Rico, Melvin W, Herman, Dena R, Belin, Thomas R, Chandler, Maria, Ramirez, Evangelina, Love, Stephanie, and McCarthy, William J
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Health Services and Systems ,Public Health ,Health Sciences ,Minority Health ,Clinical Research ,Nutrition ,Obesity ,Health Disparities ,Clinical Trials and Supportive Activities ,Prevention ,Comparative Effectiveness Research ,Basic Behavioral and Social Science ,Behavioral and Social Science ,Health Services ,Oral and gastrointestinal ,Metabolic and endocrine ,Cancer ,Stroke ,Cardiovascular ,Quality Education ,Good Health and Well Being ,Adult ,Black or African American ,California ,Community Health Centers ,Community Health Workers ,Diet ,Healthy ,Energy Intake ,Female ,Health Promotion ,Hispanic or Latino ,Humans ,Male ,Middle Aged ,Nutrition Policy ,Overweight ,Poverty ,Primary Health Care ,Quality of Life ,Research Design ,Latino ,Primary care ,Obesity treatment ,Satiety ,Satiation ,Nativity ,Behavior change ,Community health workers ,Public Health and Health Services ,Epidemiology ,Health services and systems ,Public health - Abstract
BackgroundPrimary care-based behavior change obesity treatment has long featured the Calorie restriction (CC), portion control approach. By contrast, the MyPlate-based obesity treatment approach encourages eating more high-satiety/high-satiation foods and requires no calorie-counting. This report describes study methods of a comparative effectiveness trial of CC versus MyPlate. It also describes baseline findings involving demographic characteristics and their associations with primary outcome measures and covariates, including satiety/satiation, dietary quality and acculturation.MethodsA comparative effectiveness trial was designed to compare the CC approach (n = 130) versus a MyPlate-based approach (n = 131) to treating patient overweight. Intervenors were trained community health workers. The 11 intervention sessions included two in-home health education sessions, two group education sessions, and seven telephone coaching sessions. Questionnaire and anthropometric assessments occurred at baseline, 6- and 12 months; food frequency questionnaires were administered at baseline and 12 months. Participants were overweight adult primary care patients of a federally qualified health center in Long Beach, California. Two measures of satiety/satiation and one measure of post-meal hunger comprised the primary outcome measures. Secondary outcomes included weight, waist circumference, blood pressure, dietary quality, sugary beverage intake, water intake, fruit and vegetable fiber intake, mental health and health-related quality of life. Covariates included age, gender, nativity status (U.S.-born, not U.S.-born), race/ethnicity, education, and acculturation.AnalysisBaseline characteristics were compared using chi square tests. Associations between covariates and outcome measures were evaluated using multiple regression and logistic regression.ResultsTwo thousand eighty-six adult patients were screened, yielding 261 enrollees who were 86% Latino, 8% African American, 4% White and 2% Other. Women predominated (95%). Mean age was 42 years. Most (82%) were foreign-born; 74% chose the Spanish language option. Mean BMI was 33.3 kg/m2; mean weight was 82 kg; mean waist circumference was 102 cm. Mean blood pressure was 122/77 mm. Study arms on key baseline measures did not differ except on dietary quality and sugary beverage intake. Nativity status was significantly associated with dietary quality.ConclusionsThe two treatment arms were well-balanced demographically at baseline. Nativity status is inversely related to dietary quality.Trial registrationNCT02514889 , posted on 8/4/2015.
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- 2019
11. Compliance with point-of-sale tobacco control policies and student tobacco use in Mumbai, India
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Mistry, Ritesh, Pednekar, Mangesh S, McCarthy, William J, Resnicow, Ken, Pimple, Sharmila A, Hsieh, Hsing-Fang, Mishra, Gauravi A, and Gupta, Prakash C
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Public Health ,Health Sciences ,Lung ,Cancer ,Behavioral and Social Science ,Tobacco Smoke and Health ,Prevention ,Tobacco ,Clinical Research ,Prevention of disease and conditions ,and promotion of well-being ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,Good Health and Well Being ,Adolescent ,Cross-Sectional Studies ,Female ,Guideline Adherence ,Humans ,India ,Male ,Risk Factors ,Students ,Tobacco Products ,Tobacco Use ,adolescents ,global health ,low/middle income country ,prevention ,public policy ,smokeless tobacco - Abstract
BackgroundWe measured how student tobacco use and psychological risk factors (intention to use and perceived ease of access to tobacco products) were associated with tobacco vendor compliance with India's Cigarettes and Other Tobacco Products Act provisions regulating the point-of-sale (POS) environment.MethodsWe conducted a population-based cross-sectional survey of high school students (n=1373) and tobacco vendors (n=436) in school-adjacent communities (n=26) in Mumbai, India. We used in-class self-administered questionnaires of high school students, face-to-face interviews with tobacco vendors and compliance checks of tobacco POS environments. Logistic regression models with adjustments for clustering were used to measure associations between student tobacco use, psychological risk factors and tobacco POS compliance.ResultsCompliance with POS laws was low overall and was associated with lower risk of student current tobacco use (OR 0.48, 95% CI 0.26 to 0.91) and current smokeless tobacco use (OR 0.40, 95% CI 0.21 to 0.77), when controlling for student-level and community-level tobacco use risk factors. Compliance was not associated with student intention to use tobacco (OR 0.50; 95% CI 0.21 to 1.18) and perceived ease of access to tobacco (OR 0.73; 95% CI 0.53 to 1.00).ConclusionsImproving vendor compliance with tobacco POS laws may reduce student tobacco use. Future studies should test strategies to improve compliance with tobacco POS laws, particularly in low-income and middle-income country settings like urban India.
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- 2019
12. Plant-Based Diets Are Associated With Lower Adiposity Levels Among Hispanic/Latino Adults in the Adventist Multi-Ethnic Nutrition (AMEN) Study
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Singh, Pramil N, Jaceldo-Siegl, Karen, Shih, Wendy, Collado, Nancy, Le, Lap T, Silguero, Krystal, Estevez, Dennys, Jordan, Michael, Flores, Hector, Hayes-Bautista, David E, and McCarthy, William J
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Clinical Research ,Nutrition ,Obesity ,Prevention ,Cancer ,Metabolic and endocrine ,Oral and gastrointestinal ,Cardiovascular ,Stroke ,Hispanic/Latino ,plant-based diet ,vegetarian ,obesity ,Seventh-day Adventist ,Agricultural Biotechnology ,Nutrition and dietetics - Abstract
Background: The Hispanic/Latino population in the US is experiencing high rates of obesity and cardio-metabolic disease that may be attributable to a nutrition transition away from traditional diets emphasizing whole plant foods. In the US, plant-based diets have been shown to be effective in preventing and controlling obesity and cardio-metabolic disease in large samples of primarily non-Hispanic subjects. Studying this association in US Hispanic/Latinos could inform culturally tailored interventions. Objective: To examine whether the plant-based diet pattern that is frequently followed by Hispanic/Latino Seventh-day Adventists is associated with lower levels of adiposity and adiposity-related biomarkers. Methods: The Adventist Multiethnic Nutrition Study (AMEN) enrolled 74 Seventh-day Adventists from five Hispanic/Latino churches within a 20 mile radius of Loma Linda, CA into a cross-sectional study of diet (24 h recalls, surveys) and health (anthropometrics and biomarkers). Results: Vegetarian diet patterns (Vegan, Lacto-ovo vegetarian, Pesco-vegetarian) were associated with significantly lower BMI (24.5 kg/m2 vs. 27.9 kg/m2, p = 0.006), waist circumference (34.8 in vs. 37.5 in, p = 0.01), and fat mass (18.3 kg vs. 23.9 kg, p = 0.007), as compared to non-vegetarians. Adiposity was positively associated with pro-inflammatory cytokines (Interleukin-6) in this sample, but adjusting for this effect did not alter the associations with vegetarian diet. Conclusions: Plant-based eating as practiced by US-based Hispanic/Latino Seventh-day Adventists is associated with BMI in the recommended range. Further work is needed to characterize this type of diet for use in obesity-related interventions among Hispanic/Latinos in the US.
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- 2019
13. Corrigendum: Plant-Based Diets Are Associated With Lower Adiposity Levels Among Hispanic/Latino Adults in the Adventist Multi-Ethnic Nutrition (AMEN) Study
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Singh, Pramil N, Jaceldo-Siegl, Karen, Shih, Wendy, Collado, Nancy, Le, Lap T, Silguero, Krystal, Estevez, Dennys, Jordan, Michael, Flores, Hector, Hayes-Bautista, David E, and McCarthy, William J
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Hispanic/Latino ,plant-based diet ,vegetarian ,obesity ,Seventh-day Adventist ,Agricultural Biotechnology ,Nutrition and dietetics - Abstract
[This corrects the article DOI: 10.3389/fnut.2019.00034.].
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- 2019
14. Secondary analysis of an RCT on Emergency Department- Initiated Tobacco Control: Repeatedly assessed point-prevalence abstinence up to 12 months and extension of results through a 10-year follow-up
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Weiss-Gerlach, Edith, McCarthy, William J, Wellmann, Jürgen, Graunke, Marie, Spies, Claudia, and Neuner, Bruno
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Health Services and Systems ,Public Health ,Health Sciences ,Tobacco Smoke and Health ,Behavioral and Social Science ,Clinical Research ,Prevention ,Tobacco ,Clinical Trials and Supportive Activities ,Good Health and Well Being ,tobacco use cessation ,emergency service ,hospital ,long term follow up ,long-term follow-up ,Clinical Sciences ,Public health - Abstract
IntroductionEmergency departments (EDs) are opportune places for tobacco control interventions. The 'Tobacco Control in an Urban Emergency Department' (TED) study, ISRCTN41527831, originally evaluated the effect of motivational interviewing on-site plus up to four booster telephone calls on 12-month abstinence. This study's aim was to evaluate the effect of the intervention on 7-day point-prevalence abstinence at 10 years follow-up (primary outcome) as well as on repeated point-prevalence abstinence at 1, 3, 6, 12 months and at 10 years (continual smoking abstinence, secondary outcome).MethodsAt the 10 years follow-up and after informed consent, study participants responded to a mailed questionnaire. The primary outcome was analyzed in observed-only and in all-cases analyses. The secondary outcomes were analyzed using a multiple adjusted GLMM for binary outcomes.ResultsOut of 1012 TED-study participants, 986 (97.4%) were alive and 231 (23.4% of 986) responded to the follow-up at 10 years. For observed-only and all-cases analyses, the effect of the baseline intervention on 7-day point-prevalence abstinence at the 10 years follow-up was statistically non-significant. However, when taking into account all repeated measures, the intervention significantly influenced continual abstinence with odds ratio 1.32 (95% CI: 1.01-1.73; p=0.042). Baseline motivation, perceived self-efficacy to stop smoking, and nicotine dependency were independently associated with long-term continual smoking abstinence (all p
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- 2019
15. Longitudinal study of adolescent tobacco use and tobacco control policies in India
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Mistry, Ritesh, Pednekar, Mangesh S, Gupta, Prakash C, Raghunathan, Trivellore E, Appikatla, Surekha, Puntambekar, Namrata, Adhikari, Keyuri, Siddiqi, Maqsood, and McCarthy, William J
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Public Health ,Health Sciences ,Clinical Research ,Tobacco Smoke and Health ,Tobacco ,Behavioral and Social Science ,Basic Behavioral and Social Science ,Substance Misuse ,Cancer ,Prevention ,Pediatric ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,Prevention of disease and conditions ,and promotion of well-being ,2.4 Surveillance and distribution ,Aetiology ,Cardiovascular ,Stroke ,Good Health and Well Being ,Adolescent ,Child ,Commerce ,Female ,Humans ,India ,Longitudinal Studies ,Male ,Marketing ,Public Policy ,Tobacco Industry ,Tobacco Products ,Tobacco Use ,Adolescents ,Policy ,Compliance ,Public Health and Health Services ,Epidemiology ,Health services and systems ,Public health - Abstract
BackgroundThis project will use a multilevel longitudinal cohort study design to assess whether changes in Community Tobacco Environmental (CTE) factors, measured as community compliance with tobacco control policies and community density of tobacco vendors and tobacco advertisements, are associated with adolescent tobacco use in urban India. India's tobacco control policies regulate secondhand smoke exposure, access to tobacco products and exposure to tobacco marketing. Research data about the association between community level compliance with tobacco control policies and youth tobacco use are largely unavailable, and are needed to inform policy enforcement, implementation and development.MethodsThe geographic scope will include Mumbai and Kolkata, India. The study protocol calls for an annual comprehensive longitudinal population-based tobacco use risk and protective factors survey in a cohort of 1820 adolescents ages 12-14 years (and their parent) from baseline (Wave 1) to 36-month follow-up (Wave 4). Geographic Information Systems data collection will be used to map tobacco vendors, tobacco advertisements, availability of e-cigarettes, COTPA defined public places, and compliance with tobacco sale, point-of-sale and smoke-free laws. Finally, we will estimate the longitudinal associations between CTE factors and adolescent tobacco use, and assess whether the associations are moderated by family level factors, and mediated by individual level factors.DiscussionIndia experiences a high burden of disease and mortality from tobacco use. To address this burden, significant long-term prevention and control activities need to include the joint impact of policy, community and family factors on adolescent tobacco use onset. The findings from this study can be used to guide the development and implementation of future tobacco control policy designed to minimize adolescent tobacco use.
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- 2018
16. Eating Veggies Is Fun! An Implementation Pilot Study in Partnership With a YMCA in South Los Angeles.
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Maxwell, Annette E, Castillo, Laura, Arce, Anthony A, De Anda, Teresa, Martins, David, and McCarthy, William J
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Humans ,Vegetables ,Pilot Projects ,Feeding Behavior ,Child Behavior ,Food Preferences ,Poverty Areas ,Child ,Health Promotion ,Los Angeles ,Female ,Male ,Child Nutritional Physiological Phenomena ,Recommended Dietary Allowances ,Clinical Research ,Pediatric ,Prevention ,Nutrition ,Public Health and Health Services - Abstract
Purpose and objectivesChildren eat less than recommended amounts of vegetables. Repeated taste exposure can increase children's acceptance of initially disliked vegetables. However, implementation of this strategy is lacking. We conducted a pilot study to assess the feasibility of implementing an evidence-based intervention to promote liking of initially disliked vegetables among children enrolled in a YMCA summer camp.Intervention approachWe adapted a research-tested intervention to promote child liking of vegetables for implementation in small groups. In summer 2015, 50 children aged 7 to 12 years were invited to taste 5 initially disliked vegetables daily for 10 days.Evaluation methodsChildren rated how much they liked vegetables on a 5-point emoji-like faces Likert scale at baseline and 2- and 4-week follow-up. The mean ratings for liked and initially disliked vegetables were estimated over time using mixed effects modeling.ResultsWe achieved excellent participation of parents and children; however, we experienced nonstudy-related attrition caused by disenrollment of some children from the weekly camp program. The average liking increased over time (linear trend, P = .003) for the 5 targeted vegetables but not for the other nontargeted vegetables, as predicted.Implications for public healthThis pilot study suggests that repeated vegetable tasting opportunities offered by community programs may be a practical strategy for introducing low-income, young children to new or initially disliked vegetables. The study demonstrates the feasibility of implementing a health promotion strategy that has the potential to improve population health in a community setting in an underresourced neighborhood.
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- 2018
17. A Fragment‐Based Competitive 19F LB‐NMR Platform For Hotspot‐Directed Ligand Profiling.
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McCarthy, William J., Thomas, Sherine E., Olaleye, Tayo, Boland, Jennifer A., Floto, R. Andres, Williams, Glyn, Blundell, Tom L., Coyne, Anthony G., and Abell, Chris
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LIGAND binding (Biochemistry) , *DRUG discovery , *NUCLEAR magnetic resonance spectroscopy , *BINDING sites , *SMALL molecules - Abstract
Ligand binding hotspots are regions of protein surfaces that form particularly favourable interactions with small molecule pharmacophores. Targeting interactions with these hotspots maximises the efficiency of ligand binding. Existing methods are capable of identifying hotspots but often lack assays to quantify ligand binding and direct elaboration at these sites. Herein, we describe a fragment‐based competitive 19F Ligand Based NMR (LB‐NMR) screening platform that enables routine, quantitative ligand profiling focused at ligand‐binding hotspots. As a proof of concept, the method was applied to 4′‐phosphopantetheine adenylyltransferase (PPAT) from Mycobacterium abscessus (Mabs). X‐ray crystallographic characterisation of the hits from a 960‐member fragment screen identified three ligand‐binding hotspots across the PPAT active site. From the fragment hits a collection of 19F reporter candidates were designed and synthesised. By rigorous prioritisation and use of optimisation workflows, a single 19F reporter molecule was generated for each hotspot. Profiling the binding of a set of structurally characterised ligands by competitive 19F LB‐NMR with this suite of 19F reporters recapitulated the binding affinity and site ID assignments made by ITC and X‐ray crystallography. This quantitative mapping of ligand binding events at hotspot level resolution establishes the utility of the fragment‐based competitive 19F LB‐NMR screening platform for hotspot‐directed ligand profiling [ABSTRACT FROM AUTHOR]
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- 2024
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18. The Association of Religious Affiliation with Overweight/Obesity Among South Asians: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study
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Bharmal, Nazleen H, McCarthy, William J, Gadgil, Meghana D, Kandula, Namratha R, and Kanaya, Alka M
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Public Health ,Health Sciences ,Behavioral and Social Science ,Cardiovascular ,Obesity ,Physical Activity ,Prevention ,Nutrition ,Oral and gastrointestinal ,Stroke ,Cancer ,Metabolic and endocrine ,Adult ,Aged ,Aged ,80 and over ,Asian ,Atherosclerosis ,Cohort Studies ,Community-Based Participatory Research ,Cross-Sectional Studies ,Emigrants and Immigrants ,Healthy Lifestyle ,Hinduism ,Humans ,India ,Islam ,Male ,Middle Aged ,Overweight ,Prevalence ,Risk Factors ,Spirituality ,United States ,Religious affiliation ,South Asian ,Lifestyle ,Cholesterol ,Lipids ,Public Health and Health Services ,Social Psychology ,Public health ,Clinical and health psychology - Abstract
Religiosity has been associated with greater body weight. Less is known about South Asian religions and associations with weight. Cross-sectional analysis of the MASALA study (n = 906). We examined associations between religious affiliation and overweight/obesity after controlling for age, sex, years lived in the USA, marital status, education, insurance status, health status, and smoking. We determined whether traditional cultural beliefs, physical activity, and dietary pattern mediated this association. The mean BMI was 26 kg/m2. Religious affiliation was associated with overweight/obesity for Hindus (OR 2.12; 95 % CI: 1.16, 3.89), Sikhs (OR 4.23; 95 % CI: 1.72, 10.38), and Muslims (OR 2.79; 95 % CI: 1.14, 6.80) compared with no religious affiliation. Traditional cultural beliefs (7 %), dietary pattern (1 %), and physical activity (1 %) mediated 9 % of the relationship. Interventions designed to promote healthy lifestyle changes to reduce the burden of overweight/obesity among South Asians need to be culturally and religiously tailored.
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- 2018
19. Psychometric Properties of a Modified KINDL-R Questionnaire for Adolescents and Adults, and Construction of a Brief Version, the KINDL-A(dult)B(rief) Questionnaire, KINDL-AB
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Neuner, Bruno, Krampe, Henning, McCarthy, William J, Reinke, Sarah, Kowalski, Dorothee, Clausnizer, Hartmut, Shneyder, Maria, Rocke, Angela, and Nowak-Göttl, Ulrike
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Adolescent ,Adult ,Aged ,Blood Coagulation Disorders ,Cross-Sectional Studies ,Female ,Humans ,Male ,Middle Aged ,Psychometrics ,Quality of Life ,Reproducibility of Results ,Surveys and Questionnaires ,Quality of life ,Hereditary bleeding disorder ,Transition ,KINDL-R questionnaire ,Cardiorespiratory Medicine and Haematology ,Immunology ,Cardiovascular medicine and haematology - Abstract
Background/aimsThe generic quality of life KINDL-R -questionnaire is validated for use in children/adolescents ≤16 years. The aim of this cross-sectional investigation was to modify the KINDL-R questionnaire for use in adults and to validate its psychometric properties.MethodsFive items of the KINDL-R questionnaire were adapted and the newly developed KINDL-A(dult) questionnaire administered to 255 patients with hereditary and acquired bleeding disorders (mean age 53 years). Its internal consistency and convergent and divergent construct validity were investigated and confirmatory factor analysis was used to evaluate the latent factor structure.ResultsThe KINDL-A questionnaire showed satisfactory reliability, varying construct validity, but inconclusive factor structure. The KINDL-AB(rief) was developed by removing half of the items and combining 2 sub-axes. This led to factor loadings between 0.62 and 0.91 and increased overall fit (Goodness of fit > 0.8 and Root Mean Square Error of Approximation, RMSEA, < 0.08). Results were validated in 966 healthy blood donors (mean age 38 years). In this group, the KINDL-AB questionnaire showed factor loadings between 0.43 and 0.77, Goodness of fit > 0.95 and RMSEA < 0.05.ConclusionsThe new KINDL-AB suggests sufficient to good psychometric properties in adult patients with hereditary and acquired bleeding disorders.
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- 2018
20. Smoke-Free Car Legislation and Student Exposure to Smoking
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Patel, Minal, Thai, Chan L, Meng, Ying-Ying, Kuo, Tony, Zheng, Hong, Dietsch, Barbara, and McCarthy, William J
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Public Health ,Health Sciences ,Asthma ,Cancer ,Lung ,Pediatric ,Tobacco Smoke and Health ,Tobacco ,Pediatric Research Initiative ,Health Effects of Indoor Air Pollution ,Prevention ,Prevention of disease and conditions ,and promotion of well-being ,3.1 Primary prevention interventions to modify behaviours or promote wellbeing ,Stroke ,Cardiovascular ,Respiratory ,Good Health and Well Being ,Adolescent ,Automobiles ,California ,Child ,Environmental Exposure ,Humans ,Intention ,Self Report ,Smoke-Free Policy ,Students ,Tobacco Smoke Pollution ,Tobacco Smoking ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Pediatrics ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
BackgroundPolicies protecting children from exposure to secondhand smoke (SHS) may help prevent SHS-related negative health outcomes in children and discourage them from intending to smoke in the future. In this study, we assess the impact of California's 2007 smoke-free vehicle law on changes in middle and high school students' reported exposure to smoking in cars. Secondary aims included assessing the association of student-reported exposure to smoking in vehicles and lifetime asthma diagnosis and future intentions to smoke.MethodsPopulation-weighted data from the California Student Tobacco Survey and the National Youth Tobacco Survey were used to evaluate California and national trends, respectively. Weighted logistic regression models using California Student Tobacco Survey 2011 data assessed the association between the number of days of exposure to smoking in cars and student-reported lifetime asthma diagnosis as well as intention to smoke in the future.ResultsThe proportion of California students reporting exposure to smoking in cars in the last 7 days declined
- Published
- 2018
21. Emergency Department-Initiated Tobacco Control: Update of a Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Author
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Lemhoefer, Christina, Rabe, Gwen Lisa, Wellmann, Jürgen, Bernstein, Steven L, Cheung, Ka Wai, McCarthy, William J, Lauridsen, Susanne Vahr, Spies, Claudia, and Neuner, Bruno
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Humans ,Tobacco Use Cessation ,Smoking Cessation ,Emergency Service ,Hospital ,Tobacco Use ,Emergency Service ,Hospital ,Prevention ,Tobacco ,Substance Abuse ,Tobacco Smoke and Health ,Clinical Trials and Supportive Activities ,Clinical Research ,Cancer ,Public Health and Health Services - Abstract
IntroductionA 2012 systematic review and meta-analysis of randomized controlled trials on emergency department-initiated tobacco control (ETC) showed only short-term efficacy. The aim of this study was to update data through May 2015.MethodsAfter registering the study protocol on the international prospective register of systematic reviews (PROSPERO) in May 2015, we searched 7 databases and the gray literature. Our outcome of interest was the point prevalence of tobacco-use abstinence at 1-month, 3-month, 6-month, or 12-month follow-up. We calculated the relative risk (RR) of tobacco-use abstinence after ETC at each follow-up time separately for each study and then pooled Mantel-Haenszel RRs by follow-up time. These results were pooled with results of the 7 studies included in the previous review. We calculated the effect of ETC on the combined point prevalence of tobacco-use abstinence across all follow-up times by using generalized linear mixed models.ResultsWe retrieved 4 additional studies, one published as an abstract, comprising 1,392 participants overall. The 1-month follow-up point prevalence of tobacco-use abstinence after ETC resulted in an RR of 1.49 (95% confidence interval [CI], 1.08-2.05) across 3 studies; 3-month follow-up, an RR of 1.38 (95% CI, 1.12-1.71) across 9 studies; 6-month follow-up, an RR of 1.09 (95% CI, 0.84-1.41) across 6 studies; and 12-month follow-up, an RR of 1.26 (95% CI, 1.00-1.59) across 3 studies. The effect on the combined point prevalence of abstinence was an RR of 1.40 (95% CI, 1.06-1.86) (P = .02).ConclusionETC is effective in promoting continual tobacco-use abstinence up to 12 months after intervention. ETC may be a critically important public health strategy for engaging hard-to-reach smokers in tobacco-use cessation.
- Published
- 2017
22. O and H isotopic evidence for a mantle source of water in appinite magma: An example from the late Neoproterozoic Greendale Complex, Nova Scotia
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Cawood, Ian P., Murphy, J. Brendan, McCarthy, William J., and Boyce, Adrian J.
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- 2021
- Full Text
- View/download PDF
23. Training the Next Generation of Latino Health Researchers: A Multilevel, Transdisciplinary, Community-Engaged Approach
- Author
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Kuo, Alice A, Sharif, Mienah Z, Prelip, Michael L, Glik, Deborah C, Albert, Stephanie L, Belin, Thomas, McCarthy, William J, Roberts, Christian K, Garcia, Rosa Elena, and Ortega, Alexander N
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Health Services and Systems ,Public Health ,Health Sciences ,Clinical Research ,Prevention ,Basic Behavioral and Social Science ,Cardiovascular ,Behavioral and Social Science ,Good Health and Well Being ,Cardiovascular Diseases ,Career Choice ,Health Status Disparities ,Humans ,Interdisciplinary Communication ,Leadership ,Mentors ,Mexican Americans ,Program Development ,Research Personnel ,United States ,health disparities ,Latino ,minority health ,workforce development ,Public Health and Health Services ,Curriculum and Pedagogy ,Public health - Abstract
Reducing health disparities is a national public health priority. Latinos represent the largest racial/ethnic minority group in the United States and suffer disproportionately from poor health outcomes, including cardiovascular disease risk. Academic training programs are an opportunity for reducing health disparities, in part by increasing the diversity of the public health workforce and by incorporating training designed to develop a skill set to address health disparities. This article describes the Training and Career Development Program at the UCLA Center for Population Health and Health Disparities: a multilevel, transdisciplinary training program that uses a community-engaged approach to reduce cardiovascular disease risk in two urban Mexican American communities. Results suggest that this program is effective in enhancing the skill sets of traditionally underrepresented students to become health disparities researchers and practitioners.
- Published
- 2017
24. E-cigarette specialty retailers: Data to assess the association between retail environment and student e-cigarette use
- Author
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Bostean, Georgiana, Crespi, Catherine M, Vorapharuek, Patsornkarn, and McCarthy, William J
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Education ,Public Health ,Health Sciences ,Tobacco ,Tobacco Smoke and Health ,Pediatric ,Electronic cigarettes ,Retailers ,Proximity ,Environment ,Policy - Abstract
The retail environment is a major social determinant of health, yet little is known about the e-cigarette specialty retailer environment. The e-cigarette specialty retail environment may be associated with e-cigarette use by middle and high school students, an issue that was addressed in a recent article entitled, "E-cigarette use among students and e-cigarette specialty retailer presence near schools," by Bostean and colleagues (G. Bostean, C.M. Crespi, P. Vorapharuek, W.J. McCarthy, 2016 [1]). We present data relating to e-cigarette specialty retailers in Orange County, California. We describe the data collection method (including the search methodology to identify e-cigarette specialty retailers), present descriptive retailer data including school proximity, and provide data from multi-level regressions predicting individual-level student use of e-cigarettes based on presence of an e-cigarette specialty retailer in proximity to schools.
- Published
- 2017
25. E-cigarette use among students and e-cigarette specialty retailer presence near schools
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Bostean, Georgiana, Crespi, Catherine M, Vorapharuek, Patsornkarn, and McCarthy, William J
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Public Health ,Health Sciences ,Pediatric ,Women's Health ,Adolescent ,Age Distribution ,California ,Child ,Commerce ,Electronic Nicotine Delivery Systems ,Female ,Geographic Information Systems ,Health Surveys ,Humans ,Logistic Models ,Male ,Marijuana Smoking ,Residence Characteristics ,Risk Factors ,Schools ,Smoking ,Students ,E-cigarette ,Substance use ,Retail environment ,Adolescence ,Geographic information systems ,Public Health and Health Services ,Human Geography ,Health sciences ,Human society - Abstract
ObjectiveThis study examined the association between presence of e-cigarette specialty retailers near schools and e-cigarette use among middle and high school students in Orange County (OC), CA.MethodsThe OC subsample of the 2013-2014 California Healthy Kids Survey (N=67,701) was combined with geocoded e-cigarette retailers to determine whether a retailer was present within one-quarter mile of each public school in OC. Multilevel logistic regression models evaluated individual-level and school-level e-cigarette use correlates among middle and high school students.ResultsAmong middle school students, the presence of an e-cigarette retailer within one-quarter mile of their school predicted lifetime e-cigarette use (OR=1.70, 95% CI=1.02, 2.83), controlling for confounders but no effect for current use. No significant effect was found for high school students.ConclusionsE-cigarette specialty retailers clustered around schools may be an environmental influence on student e-cigarette experimentation.
- Published
- 2016
26. Lifestyle Changes and Behavioral Approaches for the Cancer Survivor
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McCarthy, William J., primary and Carpenter, Catherine L., additional
- Published
- 2021
- Full Text
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27. Bostean et al. Respond.
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Bostean, Georgiana, Trinidad, Dennis R, and McCarthy, William J
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Biomedical and Clinical Sciences ,Health Sciences ,Electronic Nicotine Delivery Systems ,Female ,Humans ,Male ,Smoking ,Students ,Medical and Health Sciences ,Public Health ,Biomedical and clinical sciences ,Health sciences - Published
- 2016
28. Comment on Frampton et al. 2023: Propionate, not acetate, lactate or succinate, may explain carbohydrate effects on satiety
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McCarthy, William J., primary and Ferguson, Frederick, additional
- Published
- 2023
- Full Text
- View/download PDF
29. EEG microstate quantifiers and state space descriptors during anaesthesia in patients with postoperative delirium: a descriptive analysis
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Neuner, Bruno, primary, Wolter, Simone, additional, McCarthy, William J, additional, Spies, Claudia, additional, Cunningham, Colm, additional, Radtke, Finn M, additional, Franck, Martin, additional, and Koenig, Thomas, additional
- Published
- 2023
- Full Text
- View/download PDF
30. E-Cigarette Use Among Never-Smoking California Students.
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Bostean, Georgiana, Trinidad, Dennis R, and McCarthy, William J
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Tobacco ,Tobacco Smoke and Health ,Clinical Research ,Substance Misuse ,Prevention ,Cancer ,Respiratory ,Good Health and Well Being ,Adolescent ,Age Factors ,California ,Electronic Nicotine Delivery Systems ,Female ,Humans ,Male ,Sex Factors ,Smoking ,Students ,Surveys and Questionnaires ,Medical and Health Sciences ,Public Health - Abstract
We determined the extent to which adolescents who have never used tobacco try e-cigarettes. Data on the prevalence and correlates of e-cigarette use among 482,179 California middle and high school students are from the 2013-2014 California Healthy Kids Survey. Overall, 24.4% had ever used e-cigarettes (13.4% have never used tobacco and 11.0% have used tobacco), and 12.9% were current e-cigarette users (5.9% have never used tobacco). Among those who have never used tobacco, males and older students were more likely to use e-cigarettes than females and younger students. Hispanics (odds ratio [OR] = 1.60; confidence interval [CI] = 1.53, 1.67) and those of other races (OR = 1.24; CI = 1.19, 1.29) were more likely than Whites to have ever used e-cigarettes, but only among those who had never used smokeless tobacco and never smoked a whole cigarette. E-cigarette use is very prevalent among California students who have never smoked tobacco, especially among Hispanic and other race students, males, and older students.
- Published
- 2015
31. Evaluating Policy, Systems, and Environmental Change Interventions: Lessons Learned From CDC's Prevention Research Centers.
- Author
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Honeycutt, Sally, Leeman, Jennifer, McCarthy, William J, Bastani, Roshan, Carter-Edwards, Lori, Clark, Heather, Garney, Whitney, Gustat, Jeanette, Hites, Lisle, Nothwehr, Faryle, and Kegler, Michelle
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Humans ,Focus Groups ,Program Evaluation ,Information Dissemination ,Environmental Exposure ,Public Health Practice ,Organizational Policy ,Health Policy ,Systems Analysis ,Health Promotion ,Preventive Health Services ,Organizational Innovation ,Community-Institutional Relations ,United States ,Evaluation Studies as Topic ,Centers for Disease Control and Prevention ,U.S. ,Centers for Disease Control and Prevention ,U.S. ,Prevention ,Health Services ,Behavioral and Social Science ,Clinical Research ,3.1 Primary prevention interventions to modify behaviours or promote well-being ,Public Health and Health Services - Abstract
IntroductionThe field of public health is increasingly implementing initiatives intended to make policies, systems, and environments (PSEs) more supportive of healthy behaviors, even though the evidence for many of these strategies is only emerging. Our objective was 3-fold: 1) to describe evaluations of PSE-change programs in which the evaluators followed the steps of the Centers for Disease Control and Prevention's (CDC's) Framework for Program Evaluation in Public Health, 2) to share the resulting lessons learned, and 3) to assist future evaluators of PSE-change programs with their evaluation design decisions.MethodsSeven Prevention Research Centers (PRCs) applied CDC's framework to evaluate their own PSE-change initiatives. The PRCs followed each step of the framework: 1) engage stakeholders, 2) describe program, 3) focus evaluation design, 4) gather credible evidence, 5) justify conclusions, and 6) ensure use and share lessons learned.ResultsEvaluation stakeholders represented a range of sectors, including public health departments, partner organizations, and community members. Public health departments were the primary stakeholders for 4 of the 7 evaluations. Four PRCs used logic models to describe the initiatives being evaluated. Their evaluations typically included both process and outcome questions and used mixed methods. Evaluation findings most commonly focused on contextual factors influencing change (process) and the adoption or implementation of PSE-change strategies (outcome). Evaluators shared lessons learned through various channels to reach local stakeholders and broader public health audiences.ConclusionFramework for Program Evaluation in Public Health is applicable to evaluations of PSE-change initiatives. Using this framework to guide such evaluations builds practice-based evidence for strategies that are increasingly being used to promote healthful behaviors.
- Published
- 2015
32. Calling for a bold new vision of health disparities intervention research.
- Author
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Cooper, Lisa A, Ortega, Alexander N, Ammerman, Alice S, Buchwald, Dedra, Paskett, Electra D, Powell, Lynda H, Thompson, Beti, Tucker, Katherine L, Warnecke, Richard B, McCarthy, William J, Viswanath, K Vish, Henderson, Jeffrey A, Calhoun, Elizabeth A, and Williams, David R
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Epidemiologic Research Design ,Health Policy ,Health Services Accessibility ,Health Services Needs and Demand ,Health Status Disparities ,Healthcare Disparities ,Humans ,National Institutes of Health (U.S.) ,Policy Making ,Racial Groups ,Research ,United States ,Medical and Health Sciences ,Public Health - Published
- 2015
33. The Association of Duration of Residence in the United States with Cardiovascular Disease Risk Factors Among South Asian Immigrants
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Bharmal, Nazleen, Kaplan, Robert M, Shapiro, Martin F, Mangione, Carol M, Kagawa-Singer, Marjorie, Wong, Mitchell D, and McCarthy, William J
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Public Health ,Health Sciences ,Aging ,Prevention ,Heart Disease ,Nutrition ,Obesity ,Cardiovascular ,Aetiology ,2.3 Psychological ,social and economic factors ,Stroke ,Good Health and Well Being ,Acculturation ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Asia ,Southeastern ,Asians ,California ,Cardiovascular Diseases ,Emigrants and Immigrants ,Female ,Health Surveys ,Humans ,Male ,Middle Aged ,Risk Factors ,Time Factors ,Young Adult ,Asian Americans ,Immigrants ,Cardiovascular disease ,Risk factors ,United States ,Asian People ,Public Health and Health Services ,Epidemiology ,Public health ,Sociology - Abstract
South Asians are disproportionately impacted by cardiovascular disease (CVD). Our objective was to examine the association between duration of residence in the US and CVD risk factors among South Asian adult immigrants. Multivariate logistic regression analyses using pooled data from the 2005, 2007, 2009 California Health Interview Surveys. Duration of residence in the US < 15 years was significantly associated with overweight/obese BMI (OR 0.59; 95% CI 0.35, 0.98 for 5 to < 10 years), daily consumption of 5+ servings of fruits/vegetables (OR 0.37; 95% CI 0.15, 0.94 for 10 to < 15 years), and sedentary lifestyle (OR 2.11; 95% CI 1.17, 3.81 for 10 to < 15 years) compared with duration of residence ≥ 15 years after adjusting for illness burden, healthcare access, and socio-demographic characteristics. Duration of residence was not significantly associated with other CVD risk factors. Duration of residence is an important correlate of overweight/obesity and other risk factors among South Asian immigrants.
- Published
- 2015
34. A Mixed Methods Comparison of Urban and Rural Retail Corner Stores.
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McGuirt, Jared T, Pitts, Stephanie B Jilcott, Ammerman, Alice, Prelip, Michael, Hillstrom, Kathryn, Garcia, Rosa Elena, and McCarthy, William J
- Subjects
corner stores ,food environment ,rural ,spatial regression ,urban ,Rural Health - Abstract
Efforts to transform corner stores to better meet community dietary needs have mostly occurred in urban areas but are also needed in rural areas. Given important contextual differences between urban and rural areas, it is important to increase our understanding of the elements that might translate successfully to similar interventions involving stores in more rural areas. Thus, an in-depth examination and comparison of corner stores in each setting is needed. A mixed methods approach, including windshield tours, spatial visualization with analysis of frequency distribution, and spatial regression techniques were used to compare a rural North Carolina and large urban (Los Angeles) food environment. Important similarities and differences were seen between the two settings in regards to food environment context, spatial distribution of stores, food products available, and the factors predicting corner store density. Urban stores were more likely to have fresh fruits (Pearson chi2 = 27.0423; p < 0.001) and vegetables (Pearson chi2 = 27.0423; p < 0.001). In the urban setting, corner stores in high income areas were more likely to have fresh fruit (Pearson chi2 = 6.00; p = 0.014), while in the rural setting, there was no difference between high and low income area in terms of fresh fruit availability. For the urban area, total population, no vehicle and Hispanic population were significantly positively associated (p < 0.05), and median household income (p < 0.001) and Percent Minority (p < 0.05) were significantly negatively associated with corner store count. For the rural area, total population (p < 0.05) and supermarket count were positively associated (p < 0.001), and median household income negatively associated (P < 0.001), with corner store count. Translational efforts should be informed by these findings, which might influence the success of future interventions and policies in both rural and urban contexts.
- Published
- 2015
35. Contextual Factors Related to Conventional and Traditional Tobacco Use Among California Asian Indian Immigrants
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Patel, Minal, Mistry, Ritesh, Maxwell, Annette E., Divan, Hozefa A., and McCarthy, William J.
- Published
- 2018
36. The association between county political inclination and obesity: Results from the 2012 presidential election in the United States
- Author
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Shin, Michael E and McCarthy, William J
- Subjects
Obesity ,Nutrition ,Adult ,Cluster Analysis ,Female ,Geographic Mapping ,Health Behavior ,Humans ,Local Government ,Male ,Middle Aged ,Nutrition Policy ,Politics ,Population Surveillance ,Risk Factors ,Social Responsibility ,Spatial Analysis ,Statistics as Topic ,United States ,Voting ,Spatial analysis ,Spatial econometrics ,Human Movement and Sports Sciences ,Public Health and Health Services ,Public Health - Abstract
ObjectiveWe examined whether stable, county-level, voter preferences were significantly associated with county-level obesity prevalence using data from the 2012 US Presidential election. County voting preference for the 2012 Republican Party presidential candidate was used as a proxy for voter endorsement of personal responsibility approaches to reducing population obesity risk versus approaches featuring government-sponsored, multi-sectoral efforts like those recommended by the Centers for Disease Control Centers for Disease Control (CDC, 2009).MethodCartographic visualization and spatial analysis were used to evaluate the geographic clustering of obesity prevalence rates by county, and county-level support for the Republican Party candidate in the 2012 U.S. presidential election. The spatial analysis informed the spatial econometric approach employed to model the relationship between political preferences and other covariates with obesity prevalence.ResultsAfter controlling for poverty rate, percent African American and Latino populations, educational attainment, and spatial autocorrelation in the error term, we found that higher county-level obesity prevalence rates were associated with higher levels of support for the 2012 Republican Party presidential candidate.ConclusionFuture public health efforts to understand and reduce obesity risk may benefit from increased surveillance of this and similar linkages between political preferences and health risks.
- Published
- 2013
37. The association of religiosity with overweight/obese body mass index among Asian Indian immigrants in California
- Author
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Bharmal, Nazleen, Kaplan, Robert M, Shapiro, Martin F, Kagawa-Singer, Marjorie, Wong, Mitchell D, Mangione, Carol M, Divan, Hozefa, and McCarthy, William J
- Subjects
Public Health ,Health Sciences ,Obesity ,Clinical Research ,Nutrition ,Prevention ,Cancer ,Stroke ,Good Health and Well Being ,Adolescent ,Adult ,Body Mass Index ,California ,Cross-Sectional Studies ,Emigrants and Immigrants ,Female ,Hinduism ,Humans ,India ,Islam ,Logistic Models ,Male ,Middle Aged ,Overweight ,Risk Factors ,Spirituality ,Young Adult ,Asian Indian ,Religiosity ,Human Movement and Sports Sciences ,Public Health and Health Services ,Epidemiology ,Public health - Abstract
ObjectiveThe aim of this study was to examine the association between religiosity and overweight or obese body mass index among a multi-religious group of Asian Indian immigrants residing in California.MethodsWe examined cross-sectional survey data obtained from in-language telephone interviews with 3228 mostly immigrant Asian Indians in the 2004 California Asian Indian Tobacco Survey using multivariate logistic regression.ResultsHigh self-identified religiosity was significantly associated with higher BMI after adjusting for socio-demographic and acculturation measures. Highly religious Asian Indians had 1.53 greater odds (95% CI: 1.18, 2.00) of being overweight or obese than low religiosity immigrants, though this varied by religious affiliation. Religiosity was associated with greater odds of being overweight/obese for Hindus (OR 1.54; 95% CI: 1.08, 2.22) and Sikhs (OR 1.88; 95% CI: 1.07, 3.30), but not for Muslims (OR 0.69; 95% CI: 0.28, 1.70).ConclusionsReligiosity in Hindus and Sikhs, but not immigrant Muslims, appears to be independently associated with greater body mass index among Asian Indians. If this finding is confirmed, future research should identify potentially mutable mechanisms by which religion-specific religiosity affects overweight/obesity risk.
- Published
- 2013
38. A midpoint process evaluation of the Los Angeles Basin Racial and Ethnic Approaches to Community Health Across the US (REACH US) Disparities Center, 2007-2009.
- Author
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Maxwell, Annette E, Yancey, Antronette K, AuYoung, Mona, Guinyard, Joyce J, Glenn, Beth A, Mistry, Ritesh, McCarthy, William J, Fielding, Jonathan E, Simon, Paul A, and Bastani, Roshan
- Subjects
Health Services and Systems ,Public Health ,Health Sciences ,Nutrition ,Clinical Research ,Behavioral and Social Science ,Prevention ,Community Health Centers ,Community-Institutional Relations ,Health Education ,Health Plan Implementation ,Health Promotion ,Humans ,Los Angeles ,Socioeconomic Factors ,Public Health and Health Services ,Epidemiology ,Health services and systems ,Public health - Abstract
BackgroundRacial/ethnic minority groups have higher risks for disease resulting from obesity.Community contextThe University of California, Los Angeles, and the Los Angeles County Department of Public Health partnered with community organizations to disseminate culturally targeted physical activity and nutrition-based interventions in worksites.MethodsWe conducted community dialogues with people from 59 government and nonprofit health and social service agencies to develop wellness strategies for implementation in worksites. Strategies included structured group exercise breaks and serving healthy refreshments at organizational functions. During the first 2 years, we subcontracted with 6 community-based organizations (primary partners) who disseminated these wellness strategies to 29 organizations within their own professional networks (secondary worksites) through peer modeling and social support. We analyzed data from the first 2 years of the project to evaluate our dissemination approach.OutcomePrimary partners had difficulty recruiting organizations in their professional network as secondary partners to adopt wellness strategies. Within their own organizations, primary partners reported significant increases in implementation in 2 of the 6 core organizational strategies for promoting physical activity and healthy eating. Twelve secondary worksites that completed organizational assessments on 2 occasions reported significant increases in implementation in 4 of the 6 core organizational strategies.InterpretationDissemination of organizational wellness strategies by trained community organizations through their existing networks (train-the-trainer) was only marginally successful. Therefore, we discontinued this dissemination approach and focused on recruiting leaders of organizational networks.
- Published
- 2011
39. Validity of Pedometers for Measuring Exercise Adherence in Heart Failure Patients
- Author
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Evangelista, Lorraine S, Dracup, Kathleen, Erickson, Virginia, McCarthy, William J, Hamilton, Michele A, and Fonarow, Gregg C
- Subjects
Cardiovascular ,Clinical Research ,7.1 Individual care needs ,Management of diseases and conditions ,Exercise Test ,Exercise Tolerance ,Female ,Follow-Up Studies ,Heart Failure ,Humans ,Male ,Middle Aged ,Prospective Studies ,Reproducibility of Results ,Stroke Volume ,Walking ,pedometer ,adherence ,functional status ,six-minute walk test ,peak oxygen uptake ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Nursing ,Cardiovascular System & Hematology - Abstract
BackgroundMeasuring adherence to exercise is important to clinicians and researchers because inadequate adherence can adversely affect the effectiveness of an exercise program and cloud the relationship between exercise and clinical outcomes. Hence, assessment strategies for adherence to exercise, as with assessment strategies for other outcomes, must have demonstrated validity if they are to be employed with confidence. We conducted this study to determine the validity of pedometers as a measure of exercise adherence to a home-based walking program in heart failure patients.Methods and resultsExercise adherence was measured using pedometers in 38 patients (74% men) age 54.1 +/- 11.7 years who participated in a 12-month home-based walking program. A comparison of functional status as measured by the 6-minute walk distance and peak oxygen uptake (VO2 max) at 6 months into the exercise training program was made between 2 groups of participants who were thought to represent adherers and nonadherers: participants who demonstrated > or = 10% change in pedometer scores (n = 20) and those who showed no change in pedometer scores (n = 18) from baseline to 6 months. Patients who showed improvements in their pedometer scores over 6 months had better functional status at 6 months (6-minute walk distance 1718 +/- 46 versus 1012 +/- 25 meters, F = 5.699, P = .022; VO 2 max 17 +/- 0.7 versus 10 +/- 0.5 units, F = 7.162, P = .011) when compared with patients whose pedometers reflected minimal change in distance walked (ie, < or = 10%).ConclusionPedometers are inexpensive and readily available to both clinicians and researchers. The results of this study suggest that they may be a valid indicator of exercise adherence in heart failure patients who participate in a home-based walking program.
- Published
- 2005
40. Chemical Validation of Mycobacterium tuberculosis Phosphopantetheine Adenylyltransferase Using Fragment Linking and CRISPR Interference**
- Author
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El Bakali, Jamal, primary, Blaszczyk, Michal, additional, Evans, Joanna C., additional, Boland, Jennifer A., additional, McCarthy, William J., additional, Fathoni, Imam, additional, Dias, Marcio V. B., additional, Johnson, Eachan O., additional, Coyne, Anthony G., additional, Mizrahi, Valerie, additional, Blundell, Tom L., additional, Abell, Chris, additional, and Spry, Christina, additional
- Published
- 2023
- Full Text
- View/download PDF
41. Cytolytic Activity of Bacillus thuringiensis CryIC and CryIAc Toxins to Spodoptera sp. Midgut Epithelial Cells in vitro
- Author
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McCarthy, William J.
- Published
- 1997
42. Adult Intake of Minimally Processed Fruits and Vegetables: Associations with Cardiometabolic Disease Risk Factors
- Author
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Cavallo, David N., Horino, Masako, and McCarthy, William J.
- Published
- 2016
- Full Text
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43. Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference
- Author
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El Bakali, Jamal, Blaszczyk, Michal, Evans, Joanna C, Boland, Jennifer A, McCarthy, William J, Fathoni, Imam, Dias, Marcio VB, Johnson, Eachan O, Coyne, Anthony G, Mizrahi, Valerie, Blundell, Tom L, Abell, Chris, Spry, Christina, Coyne, Anthony [0000-0003-0205-5630], and Apollo - University of Cambridge Repository
- Subjects
Chemical Biology & High Throughput ,Drug Discovery ,Fragment-based ,enzymes ,Tuberculosis ,Coenzyme A ,Infectious Disease ,Genetics & Genomics ,Computational & Systems Biology - Abstract
The coenzyme A (CoA) biosynthesis pathway has attracted attention as a potential target for much-needed novel antimicrobial drugs, including for the treatment of tuberculosis (TB), the lethal disease caused by Mycobacterium tuberculosis (Mtb). Seeking to identify inhibitors of Mtb phosphopantetheine adenylyltransferase (MtbPPAT), the enzyme that catalyses the penultimate step in CoA biosynthesis, we performed a fragment screen. In doing so, we discovered three series of fragments that occupy distinct regions of the MtbPPAT active site, presenting a unique opportunity for fragment linking. Here we show how, guided by X-ray crystal structures, we could link weakly-binding fragments to produce an active site binder with a KD < 20 µM and on-target anti-Mtb activity, as demonstrated using CRISPR interference. This study represents a big step toward validating MtbPPAT as a potential drug target and designing a MtbPPAT-targeting anti-TB drug.
- Published
- 2023
- Full Text
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44. Application of Insect Cell Culture to the Study Of Bacillus Thuringiensis Toxins
- Author
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McCarthy, William J., primary
- Published
- 2018
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45. Development of potent inhibitors by fragment-linking strategies
- Author
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Bedwell, Elizabeth V, McCarthy, William J, Coyne, Anthony G, Abell, Chris, Coyne, Anthony [0000-0003-0205-5630], Abell, Chris [0000-0001-9174-1987], and Apollo - University of Cambridge Repository
- Subjects
Magnetic Resonance Spectroscopy ,Drug Design ,inhibitors ,Drug Discovery ,fragment linking ,fragment-based drug discovery ,Crystallography, X-Ray ,Ligands - Abstract
Fragment-based drug discovery (FBDD) is a method of identifying small molecule hits that can be elaborated rationally through fragment growing, merging and linking, to afford high-affinity ligands for biological targets. Despite the promised theoretical potential of fragment linking, examples are still surprisingly sparse and remain overshadowed by the successes of fragment growing. The aim of this review was to outline a number of key examples of fragment-linking strategies and discuss their strengths and limitations. Structure-based approaches including X-ray crystallography and in silico methods of fragment optimization are discussed, as well as fragment linking guided by NMR experiments. Target-guided approaches, exploiting the biological target to assemble its own inhibitors through dynamic combinatorial chemistry (DCC) and kinetic target-guided synthesis (KTGS), are identified as alternative efficient methods for fragment linking.
- Published
- 2022
46. Voluntary Health Organizations and Nonprofit Advocacy Organizations Play Critical Roles in Making Community Norms More Supportive of Healthier Eating and Increased Physical Activity
- Author
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McCarthy, William J., Goldstein, Harold, Sharp, Matthew, Batch, Eric, Williams, Jerome D., editor, Pasch, Keryn E., editor, and Collins, Chiquita A., editor
- Published
- 2013
- Full Text
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47. Physical Activity, Media, and Marketing: Advances in Communications and Media Marketing
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Yancey, Toni, McCarthy, William J., Cole, Brian, Williams, Jerome D., Williams, Jerome D., editor, Pasch, Keryn E., editor, and Collins, Chiquita A., editor
- Published
- 2013
- Full Text
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48. Validity of Temporal Measures as Proxies for Measuring Acculturation in Asian Indian Survey Respondents
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Bharmal, Nazleen, Hays, Ron D., and McCarthy, William J.
- Published
- 2014
49. Student receptivity to new school meal offerings: Assessing fruit and vegetable waste among middle school students in the Los Angeles Unified School District
- Author
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Gase, Lauren N., McCarthy, William J., Robles, Brenda, and Kuo, Tony
- Published
- 2014
- Full Text
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50. Development of potent inhibitors by fragment‐linking strategies
- Author
-
Bedwell, Elizabeth V., primary, McCarthy, William J., additional, Coyne, Anthony G., additional, and Abell, Chris, additional
- Published
- 2022
- Full Text
- View/download PDF
Catalog
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