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6. Prototypes and Ominous Objects

7. Syncopathologies

8. Reverse Engineering Collections

10. Collections and Contention

15. Mad Dreams of Reason

18. The Miracle and Madness of Science That Changed the World

21. 497 PTT-4256 is a first-in-class small molecule inhibitor of GPR65 that counteracts the low pH-dependent immunosuppressive effects on immune cells and displays pronounced anti-tumor activity in mice

36. Abstract 454: Validation of GPR35 as a novel cancer target in digestive tract cancers and discovery of potent, selective GPR35 inverse agonists

37. Abstract 668: The translational biology of small molecule GPR65 inhibitors: shared effects between mouse models and human primary tumors highlight the unique transformative potential of targeting a genetically validated innate immune checkpoint

39. Have you added a spare tire to your motorhome? Did you hire it done, or was it a DIY project? What tips can you offer to make the process go smoothly? Those are the questions we asked in January issue, and here are some of the responses we received

40. Body measurements of free-ranging snow leopards across their range

41. 1131 GRWD5769: A first-in-class inhibitor of ERAP1, generating novel cancer antigens to drive de novo anti-tumor T cell responses

42. 1324 Inhibition of acid sensing by GPR65 normalises gene expression in macrophages, increases immune cell infiltration in tumors, and restrains subcutaneous MC38 growth in mice

43. TOM MCCARTHY

44. Words vs. Images

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