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4. APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer

Author

McCann, Jennifer L., Cristini, Agnese, Law, Emily K., Lee, Seo Yun, Tellier, Michael, Carpenter, Michael A., Beghè, Chiara, Kim, Jae Jin, Sanchez, Anthony, Jarvis, Matthew C., Stefanovska, Bojana, Temiz, Nuri A., Bergstrom, Erik N., Salamango, Daniel J., Brown, Margaret R., Murphy, Shona, Alexandrov, Ludmil B., Miller, Kyle M., Gromak, Natalia, and Harris, Reuben S.

Published
2023
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5. Student Satisfaction with Feedback in a Third Year Nutrition Unit: A Strategic Approach

Author

Milne, Lisa, McCann, Jennifer, Bolton, Kristy, Savage, Julia, and Spence, Alison

Abstract

The feedback received by students on assessment tasks is a major source of their dissatisfaction with feedback generally, explaining why models of assessment continue to evolve to prioritise provision of useful feedback. Boud's notion of sustainable assessment is an example. We argue for conceptualising the sustainability of assessment practices from teachers' point of view as well. Assessment is a major component of teaching academics' workloads. The time and effort required to support particular practices should be considered "relative" to how well these are evidenced to support student learning outcomes and enhance their satisfaction with feedback. We report on a trial of this approach, from the second phase of action research examining student and staff experiences of targeted feedback on a draft assessment in a large, final year Nutrition unit. The aim of our intervention was primarily to improve student "satisfaction" with the extent to which feedback in the unit assisted them to achieve learning outcomes, but also to support student learning. Our findings indicate that, in some contexts, impactful practices like providing feedback on drafts alone may not enhance student satisfaction with feedback. Reflection on our findings led us to reframe the next phase of the project more strategically, by advocating for collaboration on course-wide, programmatic assessment, as a sustainable teaching practice and to support sustainable assessment. We call for models of assessment in higher education and course and unit evaluation to be strengthened through further research examining the sustainability of assessment practices for academics, relative to learner outcomes.

Published
2020

17. Yeast Npl3 regulates replicative senescence outside of TERRA R-loop resolution and co-transcriptional processing.

Author

Wanat, Jennifer J., McCann, Jennifer J., Tingey, Mark, Atkins, Jessica, Merlino, Corinne O., and Lee-Soety, Julia Y.

Subjects
*CELLULAR aging, *MESSENGER RNA, *GENE expression, *CELL cycle, *CELL division, *YEAST, *TELOMERASE
Abstract

AbstractEukaryotic cells without telomerase experience progressively shorter telomeres with each round of cell division until cell cycle arrest is initiated, leading to replicative senescence. When yeast TLC1, which encodes the RNA template of telomerase, is deleted, senescence is accompanied by increased expression of TERRA (non-coding telomere repeat-containing RNA). Deletion of Npl3, an RNA-processing protein with telomere maintenance functions, accelerates senescence in tlc1Δ cells and significantly increases TERRA levels. Using genetic approaches, we set out to determine how Npl3 is involved in regulating TERRA expression and maintaining telomere homeostasis. Even though Npl3 regulates hyperrecombination, we found that Npl3 does not help resolve RNA:DNA hybrids formed during TERRA synthesis in the same way as RNase H1 and H2. Furthermore, Rad52 is still required for cells to escape senescence by telomere recombination in the absence of Npl3. Npl3 also works separately from the THO/TREX pathway for processing nascent RNA for nuclear export. However, deleting Dot1, a histone methyltransferase involved in tethering telomeres to the nuclear periphery, rescued the accelerated senescence phenotype of npl3Δ cells. Thus, our study suggests that Npl3 plays an additional role in regulating cellular senescence outside of RNA:DNA hybrid resolution and co-transcriptional processing. [ABSTRACT FROM AUTHOR]

Published
2024
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27. MULTI-USE CASE STUDY: United States Scenario 1 Offshore Wind and Recreational Fishing

Author

McCann, Jennifer, Hodson, Claire, Freeman, Peter, and Walsh, John P.

Subjects
ocean multi-use, marine spatial planning, blue economy, fishery, offshore wind
Abstract

This case study emphasizes the potential for multi-use between offshore wind energy and tourism (recreational fishing). Multi-use is already successfully occurring in near-shore offshore wind demonstration projects. Multi-use in the case study area provides the opportunity to design OWE projects with the broader ecosystem in mind, ensures early involvement of the recreational fishing sector in the decision-making process, and requires advanced research and monitoring efforts to enhance biodiversity and effectively measure net- zero impact goals.

Published
2023
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28. Data from Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer

Author

Mandigo, Amy C., primary, Shafi, Ayesha A., primary, McCann, Jennifer J., primary, Yuan, Wei, primary, Laufer, Talya S., primary, Bogdan, Denisa, primary, Gallagher, Lewis, primary, Dylgjeri, Emanuela, primary, Semenova, Galina, primary, Vasilevskaya, Irina A., primary, Schiewer, Matthew J., primary, McNair, Chris M., primary, de Bono, Johann S., primary, and Knudsen, Karen E., primary

Published
2023
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29. Figure 3 from Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer

Author

Mandigo, Amy C., primary, Shafi, Ayesha A., primary, McCann, Jennifer J., primary, Yuan, Wei, primary, Laufer, Talya S., primary, Bogdan, Denisa, primary, Gallagher, Lewis, primary, Dylgjeri, Emanuela, primary, Semenova, Galina, primary, Vasilevskaya, Irina A., primary, Schiewer, Matthew J., primary, McNair, Chris M., primary, de Bono, Johann S., primary, and Knudsen, Karen E., primary

Published
2023
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30. Supplementary Figure Legends from Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer

Author

Mandigo, Amy C., primary, Shafi, Ayesha A., primary, McCann, Jennifer J., primary, Yuan, Wei, primary, Laufer, Talya S., primary, Bogdan, Denisa, primary, Gallagher, Lewis, primary, Dylgjeri, Emanuela, primary, Semenova, Galina, primary, Vasilevskaya, Irina A., primary, Schiewer, Matthew J., primary, McNair, Chris M., primary, de Bono, Johann S., primary, and Knudsen, Karen E., primary

Published
2023
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31. Figure 4 from Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer

Author

Mandigo, Amy C., primary, Shafi, Ayesha A., primary, McCann, Jennifer J., primary, Yuan, Wei, primary, Laufer, Talya S., primary, Bogdan, Denisa, primary, Gallagher, Lewis, primary, Dylgjeri, Emanuela, primary, Semenova, Galina, primary, Vasilevskaya, Irina A., primary, Schiewer, Matthew J., primary, McNair, Chris M., primary, de Bono, Johann S., primary, and Knudsen, Karen E., primary

Published
2023
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32. Figure 1 from Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer

Author

Mandigo, Amy C., primary, Shafi, Ayesha A., primary, McCann, Jennifer J., primary, Yuan, Wei, primary, Laufer, Talya S., primary, Bogdan, Denisa, primary, Gallagher, Lewis, primary, Dylgjeri, Emanuela, primary, Semenova, Galina, primary, Vasilevskaya, Irina A., primary, Schiewer, Matthew J., primary, McNair, Chris M., primary, de Bono, Johann S., primary, and Knudsen, Karen E., primary

Published
2023
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33. Figure 2 from Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer

Author

Mandigo, Amy C., primary, Shafi, Ayesha A., primary, McCann, Jennifer J., primary, Yuan, Wei, primary, Laufer, Talya S., primary, Bogdan, Denisa, primary, Gallagher, Lewis, primary, Dylgjeri, Emanuela, primary, Semenova, Galina, primary, Vasilevskaya, Irina A., primary, Schiewer, Matthew J., primary, McNair, Chris M., primary, de Bono, Johann S., primary, and Knudsen, Karen E., primary

Published
2023
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34. Supplementary Table from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer

Author

Dylgjeri, Emanuela, primary, Kothari, Vishal, primary, Shafi, Ayesha A., primary, Semenova, Galina, primary, Gallagher, Peter T., primary, Guan, Yi F., primary, Pang, Angel, primary, Goodwin, Jonathan F., primary, Irani, Swati, primary, McCann, Jennifer J., primary, Mandigo, Amy C., primary, Chand, Saswati, primary, McNair, Christopher M., primary, Vasilevskaya, Irina, primary, Schiewer, Matthew J., primary, Lallas, Costas D., primary, McCue, Peter A., primary, Gomella, Leonard G., primary, Seifert, Erin L., primary, Carroll, Jason S., primary, Butler, Lisa M., primary, Holst, Jeff, primary, Kelly, William K., primary, and Knudsen, Karen E., primary

Published
2023
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35. Supplementary Data from USP22 Functions as an Oncogenic Driver in Prostate Cancer by Regulating Cell Proliferation and DNA Repair

Author

McCann, Jennifer J., primary, Vasilevskaya, Irina A., primary, Poudel Neupane, Neermala, primary, Shafi, Ayesha A., primary, McNair, Christopher, primary, Dylgjeri, Emanuela, primary, Mandigo, Amy C., primary, Schiewer, Matthew J., primary, Schrecengost, Randy S., primary, Gallagher, Peter, primary, Stanek, Timothy J., primary, McMahon, Steven B., primary, Berman-Booty, Lisa D., primary, Ostrander, William F., primary, and Knudsen, Karen E., primary

Published
2023
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36. Supplementary Figure from A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer

Author

Dylgjeri, Emanuela, primary, Kothari, Vishal, primary, Shafi, Ayesha A., primary, Semenova, Galina, primary, Gallagher, Peter T., primary, Guan, Yi F., primary, Pang, Angel, primary, Goodwin, Jonathan F., primary, Irani, Swati, primary, McCann, Jennifer J., primary, Mandigo, Amy C., primary, Chand, Saswati, primary, McNair, Christopher M., primary, Vasilevskaya, Irina, primary, Schiewer, Matthew J., primary, Lallas, Costas D., primary, McCue, Peter A., primary, Gomella, Leonard G., primary, Seifert, Erin L., primary, Carroll, Jason S., primary, Butler, Lisa M., primary, Holst, Jeff, primary, Kelly, William K., primary, and Knudsen, Karen E., primary

Published
2023
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37. Supplementary Data from Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies

Author

Dylgjeri, Emanuela, primary, McNair, Christopher, primary, Goodwin, Jonathan F., primary, Raymon, Heather K., primary, McCue, Peter A., primary, Shafi, Ayesha A., primary, Leiby, Benjamin E., primary, de Leeuw, Renée, primary, Kothari, Vishal, primary, McCann, Jennifer J., primary, Mandigo, Amy C., primary, Chand, Saswati N., primary, Schiewer, Matthew J., primary, Brand, Lucas J., primary, Vasilevskaya, Irina, primary, Gordon, Nicolas, primary, Laufer, Talya S., primary, Gomella, Leonard G., primary, Lallas, Costas D., primary, Trabulsi, Edouard J., primary, Feng, Felix Y., primary, Filvaroff, Ellen H., primary, Hege, Kristin, primary, Rathkopf, Dana, primary, and Knudsen, Karen E., primary

Published
2023
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38. Supplementary Tables from Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies

Author

Dylgjeri, Emanuela, primary, McNair, Christopher, primary, Goodwin, Jonathan F., primary, Raymon, Heather K., primary, McCue, Peter A., primary, Shafi, Ayesha A., primary, Leiby, Benjamin E., primary, de Leeuw, Renée, primary, Kothari, Vishal, primary, McCann, Jennifer J., primary, Mandigo, Amy C., primary, Chand, Saswati N., primary, Schiewer, Matthew J., primary, Brand, Lucas J., primary, Vasilevskaya, Irina, primary, Gordon, Nicolas, primary, Laufer, Talya S., primary, Gomella, Leonard G., primary, Lallas, Costas D., primary, Trabulsi, Edouard J., primary, Feng, Felix Y., primary, Filvaroff, Ellen H., primary, Hege, Kristin, primary, Rathkopf, Dana, primary, and Knudsen, Karen E., primary

Published
2023
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39. Data from Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies

Author

Dylgjeri, Emanuela, primary, McNair, Christopher, primary, Goodwin, Jonathan F., primary, Raymon, Heather K., primary, McCue, Peter A., primary, Shafi, Ayesha A., primary, Leiby, Benjamin E., primary, de Leeuw, Renée, primary, Kothari, Vishal, primary, McCann, Jennifer J., primary, Mandigo, Amy C., primary, Chand, Saswati N., primary, Schiewer, Matthew J., primary, Brand, Lucas J., primary, Vasilevskaya, Irina, primary, Gordon, Nicolas, primary, Laufer, Talya S., primary, Gomella, Leonard G., primary, Lallas, Costas D., primary, Trabulsi, Edouard J., primary, Feng, Felix Y., primary, Filvaroff, Ellen H., primary, Hege, Kristin, primary, Rathkopf, Dana, primary, and Knudsen, Karen E., primary

Published
2023
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40. Data from USP22 Functions as an Oncogenic Driver in Prostate Cancer by Regulating Cell Proliferation and DNA Repair

Author

McCann, Jennifer J., primary, Vasilevskaya, Irina A., primary, Poudel Neupane, Neermala, primary, Shafi, Ayesha A., primary, McNair, Christopher, primary, Dylgjeri, Emanuela, primary, Mandigo, Amy C., primary, Schiewer, Matthew J., primary, Schrecengost, Randy S., primary, Gallagher, Peter, primary, Stanek, Timothy J., primary, McMahon, Steven B., primary, Berman-Booty, Lisa D., primary, Ostrander, William F., primary, and Knudsen, Karen E., primary

Published
2023
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42. Supplementary Figures S1 through S6 and Supplementary Tables S1 and S2 from The PKC/NF-κB Signaling Pathway Induces APOBEC3B Expression in Multiple Human Cancers

Author

Leonard, Brandon, primary, McCann, Jennifer L., primary, Starrett, Gabriel J., primary, Kosyakovsky, Leah, primary, Luengas, Elizabeth M., primary, Molan, Amy M., primary, Burns, Michael B., primary, McDougle, Rebecca M., primary, Parker, Peter J., primary, Brown, William L., primary, and Harris, Reuben S., primary

Published
2023
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43. PARP inhibition and pharmacological ascorbate demonstrate synergy in castration-resistant prostate cancer

Author

Gordon, Nicolas, primary, Gallagher, Peter T, additional, Neupane, Neermala Poudel, additional, Mandigo, Amy C, additional, McCann, Jennifer K, additional, Dylgjeri, Emanuela, additional, Vasilevskaya, Irina, additional, McNair, Christopher, additional, Paller, Channing J, additional, Kelly, Wm Kevin, additional, Knudsen, Karen E, additional, Shafi, Ayesha A, additional, and Schiewer, Matthew J, additional

Published
2023
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46. Mutant p53 elicits context-dependent pro-tumorigenic phenotypes

Author

McCann, Jennifer J., Vasilevskaya, Irina A., McNair, Christopher, Gallagher, Peter, Neupane, Neermala Poudel, de Leeuw, Renée, Shafi, Ayesha A., Dylgjeri, Emanuela, Mandigo, Amy C., Schiewer, Matthew J., and Knudsen, Karen E.

Abstract

The tumor suppressor gene TP53is the most frequently mutated gene in numerous cancer types, including prostate cancer (PCa). Specifically, missense mutations in TP53are selectively enriched in PCa, and cluster to particular “hot spots” in the p53 DNA binding domain with mutation at the R273 residue occurring most frequently. While this residue is similarly mutated to R273C-p53 or R273H-p53 in all cancer types examined, in PCa selective enrichment of R273C-p53 is observed. Importantly, examination of clinical datasets indicated that TP53heterozygosity can either be maintained or loss of heterozygosity (LOH) occurs. Thus, to mimic tumor-associated mutant p53, R273C-p53 and R273H-p53 isogenic PCa models were developed in the presence or absence of wild-type p53. In the absence of wild-type p53, both R273C-p53 and R273H-p53 exhibited similar loss of DNA binding, transcriptional profiles, and loss of canonical tumor suppressor functions associated with wild-type p53. In the presence of wild-type p53 expression, both R273C-p53 and R273H-p53 supported canonical p53 target gene expression yet elicited distinct cistromic and transcriptional profiles when compared to each other. Moreover, heterozygous modeling of R273C-p53 or R273H-p53 expression resulted in distinct phenotypic outcomes in vitro and in vivo. Thus, mutant p53 acts in a context-dependent manner to elicit pro-tumorigenic transcriptional profiles, providing critical insight into mutant p53-mediated prostate cancer progression.

Published
2024
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