4,118 results on '"McBrien A"'
Search Results
2. Refugee-Background Students in New Zealand and the United States: Roots and Results of Educational Policies and Practices
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McBrien, Jody L. and Hayward, Maria
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Both the United States (US) and New Zealand (NZ) have been resettling refugees since the Second World War. As such, and because of several international treaties signed by both countries, they must concern themselves with the education of resettled refugee students in their nations. In this study, the researchers examine the international agreements and national resettlement policies that shape these nations' refugee education policies. Second, educational practices for refugee students in the US and NZ using phenomenological qualitative research based on observations, interviews, and focus groups with teachers and refugee students are examined. The researchers conclude that the more systematic methods of resettlement and educational tools available to teachers in NZ through consistent national policies provide better opportunities for success than policies and practices that vary widely from state to state and even within states in the US.
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- 2022
3. A Funny Thing Happened on the Way to the Third Heaven: Reading the Secret Book of James (NHC I,2) with a Parodic Imagination
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McBrien, Kimberly Bauser
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- 2024
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4. Genomic attributes of airway commensal bacteria and mucosa
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Cuthbertson, Leah, Löber, Ulrike, Ish-Horowicz, Jonathan S., McBrien, Claire N., Churchward, Colin, Parker, Jeremy C., Olanipekun, Michael T., Burke, Conor, McGowan, Aisling, Davies, Gwyneth A., Lewis, Keir E., Hopkin, Julian M., Chung, Kian Fan, O’Carroll, Orla, Faul, John, Creaser-Thomas, Joy, Andrews, Mark, Ghosal, Robin, Piatek, Stefan, Willis-Owen, Saffron A. G., Bartolomaeus, Theda U. P., Birkner, Till, Dwyer, Sarah, Kumar, Nitin, Turek, Elena M., William Musk, A., Hui, Jennie, Hunter, Michael, James, Alan, Dumas, Marc-Emmanuel, Filippi, Sarah, Cox, Michael J., Lawley, Trevor D., Forslund, Sofia K., Moffatt, Miriam F., and Cookson, William. O. C.
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- 2024
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5. Advancing Community Care and Access to Follow-Up after Acute Kidney Injury Hospitalization: A Randomized Clinical Trial
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Pannu, Neesh, McBrien, Kerry A., Tan, Zhi, Ahmad, Nasreen, Bignell, Coralea, Benterud, Eleanor, Palechuk, Taylor, Harrison, Tyrone G., Manns, Braden J., Scott-Douglas, Nairne, and James, Matthew T.
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- 2024
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6. Nutritional interventions for Indigenous adults in Canada - opportunities to sustain health and cultural practices: a scoping review
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Ashley Amson, Jessica Zhang, Levi Frehlich, Yunqi Ji, Carly Checholik, Patricia Doyle-Baker, Lynden Crowshoe, Kerry McBrien, and Sonja Wicklum
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Indigenous ,Canada ,nutrition ,interventions ,community-based ,wholistic ,Arctic medicine. Tropical medicine ,RC955-962 - Abstract
Indigenous People in Canada possess rich cultural traditions, intertwined with a strong connection to nature. However, colonisation and contemporary challenges have given rise to changes in lifestyle and culture, resulting in health and nutrition disparities within these communities. The goal of this review was to explore the available literature of existing Indigenous nutrition programs for adults in Canada. Arksey and O’Malley’s scoping review protocol was used to conduct the search between July 2020 and February 2023. Articles were obtained from MEDLINE (Ovid), PsycInfo, Embase (Ovid), CINAHL (EBSCO), Web of Science, Scopus (Elsevier), Canadian Business and Current Affairs (Proquest), and Google Scholar. We identified 24 publications, with 19 being unique interventions. Common themes among programs included integrating traditional foods and cultural values, adapted programming to local needs, empowering community members, using a multidisciplinary collaboration, and leveraging social activities, all of which highlight the need for holistic strategies amid complex historical, social, and environmental factors. Overall, this review emphasises the need for continued support and development of Indigenous-led nutritional initiatives to promote health and well-being among Indigenous adults in Canada. Ensuring culturally relevant and sustainable solutions is crucial for addressing nutritional health disparities and fostering long-term positive outcomes.
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- 2024
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7. Perinatal Cardiac Functional Adaptation in Hypoplastic Left Heart Syndrome: A Longitudinal Analysis
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Patey, Olga, Hornberger, Lisa K., McBrien, Angela, Lin, Lily, Khoo, Nee S., and Eckersley, Luke
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- 2024
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8. A Comparison of Perinatal Circulatory Transition in Critical Right and Left Heart Obstructive Lesions
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Mugaba, Proscovia M., Hornberger, Lisa K., McBrien, Angela, Mills, Lindsay, and Eckersley, Luke G.
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- 2024
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9. Genomic attributes of airway commensal bacteria and mucosa
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Leah Cuthbertson, Ulrike Löber, Jonathan S. Ish-Horowicz, Claire N. McBrien, Colin Churchward, Jeremy C. Parker, Michael T. Olanipekun, Conor Burke, Aisling McGowan, Gwyneth A. Davies, Keir E. Lewis, Julian M. Hopkin, Kian Fan Chung, Orla O’Carroll, John Faul, Joy Creaser-Thomas, Mark Andrews, Robin Ghosal, Stefan Piatek, Saffron A. G. Willis-Owen, Theda U. P. Bartolomaeus, Till Birkner, Sarah Dwyer, Nitin Kumar, Elena M. Turek, A. William Musk, Jennie Hui, Michael Hunter, Alan James, Marc-Emmanuel Dumas, Sarah Filippi, Michael J. Cox, Trevor D. Lawley, Sofia K. Forslund, Miriam F. Moffatt, and William. O. C. Cookson
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Biology (General) ,QH301-705.5 - Abstract
Abstract Microbial communities at the airway mucosal barrier are conserved and highly ordered, in likelihood reflecting co-evolution with human host factors. Freed of selection to digest nutrients, the airway microbiome underpins cognate management of mucosal immunity and pathogen resistance. We show here the initial results of systematic culture and whole-genome sequencing of the thoracic airway bacteria, identifying 52 novel species amongst 126 organisms that constitute 75% of commensals typically present in heathy individuals. Clinically relevant genes encode antimicrobial synthesis, adhesion and biofilm formation, immune modulation, iron utilisation, nitrous oxide (NO) metabolism and sphingolipid signalling. Using whole-genome content we identify dysbiotic features that may influence asthma and chronic obstructive pulmonary disease. We match isolate gene content to transcripts and metabolites expressed late in airway epithelial differentiation, identifying pathways to sustain host interactions with microbiota. Our results provide a systematic basis for decrypting interactions between commensals, pathogens, and mucosa in lung diseases of global significance.
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- 2024
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10. Fetal Surveillance in High-Risk Fetal Cardiac Disease: Frequency, Results and Relationship with Survival
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Samuel, Rosh, Trakulmungkichkarn, Thotsapon, Hornberger, Lisa K., Stryker, Trina, Eckersley, Luke, and McBrien, Angela
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- 2024
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11. Exploring the Impacts of Learning Modality Changes: Validation of the Learning Modality Change Community of Inquiry and Self-Efficacy Scales
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Jia, Yuane, Gesing, Peggy, Jun, Hyun-Jin, Burbage, Amanda K., Hoang, Thuha, Kulo, Violet, Cestone, Christina, McBrien, Sarah, and Tornwall, Joni
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The rapid learning environment transition initiated by the COVID-19 pandemic impacted students' perception of, comfort with, and self-efficacy in the online learning environment. Garrison's Community of Inquiry framework provides a lens for examining students' online learning experiences through three interdependent elements: social presence, cognitive presence, and teaching presence. Researchers in this study developed and validated the Learning Modality Change Community of Inquiry and Self-Efficacy scales to measure health professions students' self-efficacy with online learning, while exploring how cognitive, social, and teaching presence is experienced by students who transition from one learning environment to another. The two scales demonstrate strong validity and reliability evidence and can be used by educators to explore the impacts of learning modality changes on student learning experiences. As learning environments continue to evolve, understanding the impact of these transitions can inform how educators consider curriculum design and learning environment changes.
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- 2023
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12. Exemplary Practices of New Zealand Teachers Preparing Refugee Students for Resettlement: The First Six Weeks
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McBrien, Jody L.
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- 2023
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13. SN 2020kyg and the rates of faint Iax Supernovae from ATLAS
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Srivastav, Shubham, Smartt, S. J., Huber, M. E., Chambers, K. C., Angus, C. R., Chen, T. -W., Callan, F. P., Gillanders, J. H., McBrien, O. R., Sim, S. A., Fulton, M., Hjorth, J., Smith, K. W., Young, D. R., Auchettl, K., Anderson, J. P., Pignata, G., de Boer, T. J. L., Lin, C. -C., and Magnier, E. A.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present multi-wavelength follow-up observations of the ATLAS discovered faint Iax supernova SN 2020kyg that peaked at an absolute magnitude of $M_g \approx -14.9 \pm 0.2$, making it another member of the faint Iax supernova population. The bolometric light curve requires only $\approx 7 \times 10^{-3}$ M$_{\odot}$ of radioactive $^{56}$Ni, with an ejected mass of $M_{\rm ej} \sim 0.4$ M$_{\odot}$ and a low kinetic energy of $E \approx 0.05 \pm 0.02 \times 10^{51}$ erg. We construct a homogeneous volume-limited sample of 902 transients observed by ATLAS within 100 Mpc during a 3.5 year span. Using this sample, we constrain the rates of faint Iax ($M_r \gtrsim -16$) events within 60 Mpc at $12^{+14}_{-8}\%$ of the SN Ia rate. The overall Iax rate, at $15^{+17}_{-9}\%$ of the Ia rate, is dominated by the low-luminosity events, with luminous SNe Iax ($M_r \lesssim -17.5$) like 2002cx and 2005hk accounting for only $0.9^{+1.1}_{-0.5}\%$ of the Ia rate (a 2$\sigma$ upper limit of approximately 3\%). We favour the hybrid CONe WD + He star progenitor channel involving a failed deflagration of a near Chandrasekhar mass white dwarf, expected to leave a bound remnant and a surviving secondary companion, as a candidate explanation for faint Iax explosions. This scenario requires short delay times, consistent with the observed environments of SNe Iax. Furthermore, binary population synthesis calculations have suggested rates of $1-18\%$ of the SN Ia rate for this channel, consistent with our rate estimates., Comment: Accepted to MNRAS after minor revision
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- 2021
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14. Managing Medications During “Sick Days” in Patients With Diabetes, Kidney, and Cardiovascular Conditions: A Theory-informed Approach to Intervention Design and Implementation
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Watson, Kaitlyn E., Dhaliwal, Kirnvir, Benterud, Eleanor, Robertshaw, Sandra, Verdin, Nancy, McMurtry, Ella, Lamont, Nicole, Drall, Kelsea M., Gill, Sarah, Campbell, David J.T., McBrien, Kerry, Tsuyuki, Ross T., Pannu, Neesh, James, Matthew T., and Donald, Maoliosa
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- 2024
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15. Results from the BETTER WISE trial: a pragmatic cluster two arm parallel randomized controlled trial for primary prevention and screening in primary care during the COVID-19 pandemic
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Manca, Donna Patricia, Fernandes, Carolina, Lofters, Aisha, Aubrey-Bassler, Kris, Shea-Budgell, Melissa, Campbell-Scherer, Denise, Sopcak, Nicolette, Meaney, Christopher, Moineddin, Rahim, McBrien, Kerry, Krueger, Paul, Wong, Tracy, and Grunfeld, Eva
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- 2023
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16. Spread of Makoyoh’sokoi (Wolf Trail): a community led, physical activity-based, holistic wellness program for Indigenous women in Canada
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Frehlich, Levi, Amson, Ashley, Doyle-Baker, Patricia, Black, Tia, Boustead, Dawn, Cameron, Erin, Crowshoe, Lynden (Lindsay), McBrien, Kerry, Ji, Yunqi (Jacob), McGuire, Ashlee, Oliver, Alicia, Tuttauk, Loretta, Zhang, Jessica, Checholik, Carly, and Wicklum, Sonja
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- 2023
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17. Spatiotemporal distribution of power outages with climate events and social vulnerability in the USA
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Do, Vivian, McBrien, Heather, Flores, Nina M., Northrop, Alexander J., Schlegelmilch, Jeffrey, Kiang, Mathew V., and Casey, Joan A.
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- 2023
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18. Characterising pathways driving aggressive biology and chemoresistance in triple negative breast cancers biology and chemoresistance in triple negative breast cancers
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McBrien, Charlotte, Buckley, Niamh, and Mullan, Paul
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Oncology ,breast cancer ,chemoresistance ,triple negative breast cancer ,CDKN1A ,ABCB1 ,TP63 ,molecular biology ,cell signalling ,RNAi ,drug resistance ,chemotherapy - Abstract
This body of work served to investigate the mechanisms driving chemoresistance in a series of in vitro TNBC cell line models. Molecular characterisation and comparison of drug resistant models allowed for the identification of promising druggable targets, whose efficacy in restoring chemosensitivity was assessed via a number of methods, including RNAi, CRISPR, and targeted inhibition. In all, the preliminary identification of a means to sensitise an otherwise highly aggressive cancer to chemotherapeutics, represents an essential step in order to improve current standard of care practices of an otherwise intractable disease.
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- 2022
19. Chronic disease prevention and screening outcomes for patients with and without financial difficulty: a secondary analysis of the BETTER WISE cluster randomised controlled trial
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Eva Grunfeld, Kris Aubrey-Bassler, Rahim Moineddin, Denise Campbell-Scherer, Melissa Shea-Budgell, Kerry McBrien, Aisha K Lofters, Christopher Meaney, Andrew David Pinto, Tracy Wong, Donna P Manca, Dhruvesh Patel, and Carolina Fernandes
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Medicine - Abstract
Objective Building on Existing Tools To improvE chronic disease pRevention and screening in primary care Wellness of cancer survIvorS and patiEnts (BETTER WISE) was designed to assess the effectiveness of a cancer and chronic disease prevention and screening (CCDPS) programme. Here, we compare outcomes in participants living with and without financial difficulty.Design Secondary analysis of a cluster-randomised controlled trial.Setting Patients of 59 physicians from 13 clinics enrolled between September 2018 and August 2019.Participants 596 of 1005 trial participants who responded to a financial difficulty screening question at enrolment.Intervention 1-hour CCDPS visit versus usual care.Outcome measures Eligibility for a possible 24 CCDPS actions was assessed at baseline and the primary outcome was the percentage of eligible items that were completed at 12-month follow-up. We also compared the change in response to the financial difficulty screening question between baseline and follow-up.Results 55 of 265 participants (20.7%) in the control group and 69 of 331 participants (20.8%) in the intervention group reported living with financial difficulty. The primary outcome was 29% (95% CI 26% to 33%) for intervention and 23% (95% CI 21% to 26%) for control participants without financial difficulty (p=0.01). Intervention and control participants with financial difficulty scored 28% (95% CI 24% to 32%) and 32% (95% CI 27% to 38%), respectively (p=0.14). In participants who responded to the financial difficulty question at both time points (n=302), there was a net decrease in the percentage of participants who reported financial difficulty between baseline (21%) and follow-up (12%, p
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- 2024
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20. Predicting High‐Risk Fetal Cardiac Disease Anticipated to Need Immediate Postnatal Stabilization and Intervention with Planned Pediatric Cardiac Operating Room Delivery
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Amol Moray, Proscovia M. Mugaba, Chloe Joynt, Angela McBrien, Luke G. Eckersley, Ernest Phillipos, Paula Holinski, Lindsay Ryerson, James Yashu Coe, Sujata Chandra, Billy Wong, Michele Derbyshire, Maria Lefebvre, Mohammed Al Aklabi, and Lisa K. Hornberger
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cardiorespiratory compromise ,congenital heart disease ,fetal echocardiography ,fetal heart disease ,neonatology ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Distances between delivery and cardiac services can make the care of fetuses with cardiac disease at risk of acute cardiorespiratory instability at birth a challenge. In 2013 we implemented a fetal echocardiography‐based algorithm targeting fetuses considered high risk for acute cardiorespiratory instability at ≤2 hours of birth for delivery in our pediatric cardiac operating room of our children's hospital, and, herein, examine our experience. Methods and Results We reviewed maternal and postnatal medical records of all fetuses with cardiac disease encountered January 2013 to March 2022 considered high risk for acute cardiorespiratory instability. Secondary analysis was performed including all fetuses with diagnoses of d‐transposition of the great arteries/intact ventricular septum (d‐TGA/IVS) and hypoplastic left heart syndrome (HLHS) encountered over the study period. Forty fetuses were considered high risk for acute cardiorespiratory instability: 15 with d‐TGA/IVS and 7 with HLHS with restrictive atrial septum, 4 with absent pulmonary valve syndrome, 3 with obstructed anomalous pulmonary veins, 2 with severe Ebstein anomaly, 2 with thoracic/intracardiac tumors, and 7 others. Pediatric cardiac operating room delivery occurred for 33 but not for 7 (5 with d‐TGA/IVS, 2 with HLHS with restrictive atrial septum). For high‐risk cases, fetal echocardiography had a positive predictive value of 50% for intervention/extracorporeal membrane oxygenation/death at ≤2 hours and 70% at ≤24 hours. Of “low‐risk” cases, 6/46 with d‐TGA/IVS and 0/45 with HLHS required intervention at ≤2 hours. Fetal echocardiography for predicting intervention/extracorporeal membrane oxygenation/death at ≤2 hours had a sensitivity of 67%, specificity 93%, and positive and negative predictive values of 80% and 87%, respectively, for d‐TGA/IVS, and 100%, 95%, 71%, and 100% for HLHS, respectively. Conclusions Fetal echocardiography can predict the need for urgent intervention in a majority with d‐TGA/IVS and HLHS and in half of the entire spectrum of high‐risk cardiac disease.
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- 2024
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21. Advancing Community Care and Access to Follow-up After Acute Kidney Injury Hospitalization: Design of the AFTER AKI Randomized Controlled Trial
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Meha Bhatt, Eleanor Benterud, Taylor Palechuk, Coralea Bignell, Nasreen Ahmed, Kerry McBrien, Matthew T. James, and Neesh Pannu
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Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Background: Acute kidney injury (AKI) is a common complication among hospitalized patients with long-term implications including chronic kidney disease (CKD). Although models are available to predict the risk of advanced CKD after AKI, there is limited evidence regarding follow-up for patients with AKI after hospital discharge, resulting in variable follow-up care. A risk-stratified follow-up approach may improve appropriateness and efficiency of management for CKD among patients at risk of declining kidney function following AKI. Objective: The objective was to compare and evaluate the use of a risk-stratified approach to follow-up care vs usual care for patients with AKI after hospital discharge. Design: This study was a pragmatic randomized controlled trial. Setting: This study was conducted in 2 large urban hospitals in Alberta, Canada. Patients: Hospitalized patients with AKI (KDIGO stage 2 or 3) not previously under the care of a nephrologist, expected to survive greater than 90 days being discharged home. Measurements: We will evaluate whether guideline-recommended CKD care processes are initiated within 90 days, including statin use, angiotensin-converting enzyme inhibitor (ACEi)/angiotensin II receptor blocker (ARB) use in those with proteinuria or diabetes, and nephrologist follow-up if sustained eGFR
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- 2024
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22. Struggling to interpret Islam in Central Asia
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McBrien, Julie, primary
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- 2023
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23. Results from the BETTER WISE trial: a pragmatic cluster two arm parallel randomized controlled trial for primary prevention and screening in primary care during the COVID-19 pandemic
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Donna Patricia Manca, Carolina Fernandes, Aisha Lofters, Kris Aubrey-Bassler, Melissa Shea-Budgell, Denise Campbell-Scherer, Nicolette Sopcak, Christopher Meaney, Rahim Moineddin, Kerry McBrien, Paul Krueger, Tracy Wong, and Eva Grunfeld
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Cancer survivors ,Chronic disease ,Clinical practice guidelines ,Prevention ,Primary care ,Screening ,Medicine (General) ,R5-920 - Abstract
Abstract Background Cancer and chronic diseases are a major cost to the healthcare system and multidisciplinary models with access to prevention and screening resources have demonstrated improvements in chronic disease management and prevention. Research demonstrated that a trained Prevention Practitioner (PP) in multidisciplinary team settings can improve achievement of patient level prevention and screening actions seven months after the intervention. Methods We tested the effectiveness of the PP intervention in a pragmatic two-arm cluster randomized controlled trial. Patients aged 40–65 were randomized at the physician level to an intervention group or to a wait-list control group. The intervention consisted of a patient visit with a PP. The PP received training in prevention and screening and use of the BETTER WISE tool kit. The effectiveness of the intervention was assessed using a composite outcome of the proportion of the eligible prevention and screening actions achieved between intervention and control groups at 12-months. Results Fifty-nine physicians were recruited in Alberta, Ontario, and Newfoundland and Labrador. Of the 1,005 patients enrolled, 733 (72.9%) completed the 12-month analysis. The COVID-19 pandemic occurred during the study time frame at which time nonessential prevention and screening services were not available and in-person visits with the PP were not allowed. Many patients and sites did not receive the intervention as planned. The mean composite score was not significantly higher in patients receiving the PP intervention as compared to the control group. To understand the impact of COVID on the project, we also considered a subset of patients who had received the intervention and who attended the 12-month follow-up visit before COVID-19. This assessment demonstrated the effectiveness of the BETTER visits, similar to the findings in previous BETTER studies. Conclusions We did not observe an improvement in cancer and chronic disease prevention and screening (CCDPS) outcomes at 12 months after a BETTER WISE prevention visit: due to the COVID-19 pandemic, the study was not implemented as planned. Though benefits were described in those who received the intervention before COVID-19, the sample size was too small to make conclusions. This study may be a harbinger of a substantial decrease and delay in CCDPS activities under COVID restrictions. Trial registration ISRCTN21333761. Registered on 19/12/2016. http://www.isrctn.com/ISRCTN21333761 .
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- 2023
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24. Cultivating a Mindset for Inclusive Learning Design
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Cherrez, Nadia Jaramillo, McBrien, Elisabeth Babcock, Scott, Christine, Spector, J. Michael, Series Editor, Bishop, M.J., Series Editor, Ifenthaler, Dirk, Series Editor, Yuen, Allan, Series Editor, Hokanson, Brad, editor, Exter, Marisa, editor, Schmidt, Matthew M., editor, and Tawfik, Andrew A., editor
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- 2023
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25. The Inclusion of LGBTQI+ Students across Education Systems: An Overview. OECD Education Working Papers. No. 273
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Organisation for Economic Cooperation and Development (OECD) (France), McBrien, Jody, Rutigliano, Alexandre, and Sticca, Adam
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Students who identify as lesbian, gay, bisexual, transgender, queer, intersex or somewhere else on the gender/sexuality spectrum (LGBTQI+) are among the diverse student groups in need of extra support and protection in order to succeed in education and reach their full potential. Because they belong to a minority that is often excluded by heteronormative/cisgender people, they are often the targets of physical and psychological harassment. Such discrimination can place them at risk for isolation, reduced academic achievement, and physical and mental harm. This paper provides a brief history of how the LGBTQI+ population has often been misunderstood and labelled in order to understand challenges faced by students who identify as a part of this population. It continues by considering supportive educational policies and programmes implemented from national to local levels across OECD countries. Finally, the paper considers policy gaps and discusses policy implications to strengthen equity and inclusion for LGBTQI+ students.
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- 2022
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26. Fetal Echocardiography From 10 to 15 Weeks of Gestation—Reliability, Genetic Associations, and Outcomes
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Rittey, Leila, Davidson, Hannah, Hornberger, Lisa K., Eckersley, Luke, Boehme, Cleighton, and McBrien, Angela
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- 2024
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27. Screening and Diagnosis of Chronic Kidney Disease in Adults Living With Diabetes: A Retrospective Cohort Study Using the Canadian Primary Care Sentinel Surveillance Network
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Black, Jason E., Campbell, David J.T., Ronksley, Paul E., McBrien, Kerry A., and Williamson, Tyler S.
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- 2024
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28. Spread of Makoyoh’sokoi (Wolf Trail): a community led, physical activity-based, holistic wellness program for Indigenous women in Canada
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Levi Frehlich, Ashley Amson, Patricia Doyle-Baker, Tia Black, Dawn Boustead, Erin Cameron, Lynden (Lindsay) Crowshoe, Kerry McBrien, Yunqi (Jacob) Ji, Ashlee McGuire, Alicia Oliver, Loretta Tuttauk, Jessica Zhang, Carly Checholik, and Sonja Wicklum
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Education ,Health ,Indigenous ,Physical activity ,Wellness ,Women ,Nutritional diseases. Deficiency diseases ,RC620-627 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Globally, Indigenous populations have been impacted by colonization. Populations who have endured colonization are at higher risk of developing chronic diseases. Canada’s Truth and Reconciliation Commission emphasizes reducing barriers to participation in physical activity and recommends the creation of culturally relevant and supportive policies and programing. Physical activity is a cornerstone in health promotion and public health to combat chronic diseases; however, in Canada, Indigenous developed physical activity programing is sparse, and those targeting women are non-existent in some regions. Makoyoh'sokoi (The Wolf Trail Program) is an 18-week long, holistic wellness program that was created by and for Indigenous women. Makoyoh'sokoi was developed by communities following extensive consultation and cultural oversight. Makoyoh'sokoi’s core program consists of 12 weeks of weekly physical activity programing and health education, followed by another 6 weeks of weekly health education. Notably, communities have control over the program to modify based on individual needs and challenges. Programs commence and conclude with a ceremony with Elders giving a blessing and opening each other to connection. The goals of Makoyoh'sokoi are to empower women, improve health outcomes, and to implement a sustainable program by training a network of community members in their respective communities to facilitate delivery.
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- 2023
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29. Managing ‘sick days’ in patients with chronic conditions: An exploration of patient and healthcare provider experiences
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Kirnvir K. Dhaliwal, Kaitlyn E. Watson, Nicole C. Lamont, Kelsea M. Drall, Maoliosa Donald, Matthew T. James, Sandra Robertshaw, Nancy Verdin, Eleanor Benterud, Kerry McBrien, Sarah Gil, Ross T. Tsuyuki, Neesh Pannu, and David J. T. Campbell
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chronic condition(s) ,qualitative research ,sick day guidance ,sick day management ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Introduction People with chronic medical conditions often take medications that improve long‐term outcomes but which can be harmful during acute illness. Guidelines recommend that healthcare providers offer instructions to temporarily stop these medications when patients are sick (i.e., sick days). We describe the experiences of patients managing sick days and of healthcare providers providing sick day guidance to their patients. Methods We undertook a qualitative descriptive study. We purposively sampled patients and healthcare providers from across Canada. Adult patients were eligible if they took at least two medications for diabetes, heart disease, high blood pressure and/or kidney disease. Healthcare providers were eligible if they were practising in a community setting with at least 1 year of experience. Data were collected using virtual focus groups and individual phone interviews conducted in English. Team members analyzed transcripts using conventional content analysis. Results We interviewed 48 participants (20 patients and 28 healthcare providers). Most patients were between 50 and 64 years of age and identified their health status as ‘good’. Most healthcare providers were between 45 and 54 years of age and the majority practised as pharmacists in urban areas. We identified three overarching themes that summarize the experiences of patients and healthcare providers, largely suggesting a broad spectrum in approaches to managing sick days: Individualized Communication, Tailored Sick Day Practices, and Variation in Knowledge of Sick Day Practices and Relevant Resources. Conclusion It is important to understand the perspectives of both patients and healthcare providers with respect to the management of sick days. This understanding can be used to improve care and outcomes for people living with chronic conditions during sick days. Patient or Public Contribution Two patient partners were involved from proposal development to the dissemination of our findings, including manuscript development. Both patient partners took part in team meetings and contributed to team decision‐making. Patient partners also participated in data analysis by reviewing codes and theme development. Furthermore, patients living with various chronic conditions and healthcare providers participated in focus groups and individual interviews.
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- 2023
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30. A shifting terrain: Understanding the perspectives of walk-in physicians on their roles amid worsening primary care access in Ontario, Canada.
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Braeden A Terpou, Lauren Lapointe-Shaw, Ruoxi Wang, Danielle Martin, Mina Tadrous, Sacha Bhatia, Jennifer Shuldiner, Simon Berthelot, Niels Thakkar, Kerry McBrien, Christine Salahub, Tara Kiran, Noah Ivers, and Laura Desveaux
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Medicine ,Science - Abstract
BackgroundHigh-quality primary care is associated with better health outcomes and more efficient and equitable health system performance. However, the rate of primary care attachment is falling, and timely access to primary care is worsening, driving many patients to use walk-in clinics for their comprehensive primary care needs. This study sought to explore the experiences and perceived roles and responsibilities of walk-in physicians in this current climate. Methods: Qualitative interviews were conducted with nineteen physicians currently providing walk-in care in Ontario, Canada between May and December 2022.ResultsLimited capacity for continuity and comprehensiveness of care were identified as major sources of professional tension for walk-in physicians. Divergent perspectives on their roles were anchored in how physicians viewed their professional identity. Some saw providing continuous and comprehensive care as an infringement on their professional role; others saw their professional role as more flexible and responsive to population needs. Regardless of their professional identity, participants reported feeling ill-equipped to manage the swell of unattached patients, citing a lack of time, resources, connectivity to the system, and remuneration flexibility. Conclusions: As practice demands of walk-in clinics change, an evolution in the professional roles and responsibilities of walk-in physicians follows. However, the resources, structure, and incentives of walk-in care have not evolved to reflect this, leaving physicians to set their own professional boundaries with patients. This results in increasing variations in care and confusion across the primary care sector around who is responsible for what, when, and how.
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- 2024
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31. PS15cey and PS17cke: prospective candidates from the Pan-STARRS Search for Kilonovae
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McBrien, Owen R., Smartt, Stephen J., Huber, Mark E., Rest, Armin, Chambers, Ken C., Barbieri, Claudio, Bulla, Mattia, Jha, Saurabh, Gromadzki, Mariusz, Srivastav, Shubham, Smith, Ken W., Young, David R., McLaughlin, Shaun, Inserra, Cosimo, Nicholl, Matt, Fraser, Morgan, Maguire, Kate, Chen, Ting-Wan, Wevers, Thomas, Anderson, Joseph P., Müller-Bravo, Tomás E., E., Felipe Olivares, Kankare, Erkki, Gal-Yam, Avishay, and Waters, Christopher
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Time domain astronomy was revolutionised with the discovery of the first kilonova, AT2017gfo, in August 2017 which was associated with the gravitational wave signal GW170817. Since this event, numerous wide-field surveys have been optimising search strategies to maximise their efficiency of detecting these fast and faint transients. With the Panoramic Survey Telescope and Rapid Response System (Pan-STARRS), we have been conducting a volume limited survey for intrinsically faint and fast fading events to a distance of $D\simeq200$ Mpc. Two promising candidates have been identified from this archival search, with sparse data - PS15cey and PS17cke. Here we present more detailed analysis and discussion of their nature. We observe that PS15cey was a luminous, fast declining transient at 320 Mpc. Models of BH-NS mergers with a very stiff equation of state could possibly reproduce the luminosity and decline but the physical parameters are extreme. A more likely scenario is that this was a SN2018kzr-like merger event. PS17cke was a faint and fast declining event at 15 Mpc. We explore several explosion scenarios of this transient including models of it as a NS-NS and BH-NS merger, the outburst of a massive luminous star, and compare it against other known fast fading transients. Although there is uncertainty in the explosion scenario due to difficulty in measuring the explosion epoch, we find PS17cke to be a plausible kilonova candidate from the model comparisons., Comment: 17 pages, 9 figures, 1 table. Accepted by MNRAS (2020-10-21)
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- 2020
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32. Design and operation of the ATLAS Transient Science Server
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Smith, K. W., Smartt, S. J., Young, D. R., Tonry, J. L., Denneau, L., Flewelling, H., Heinze, A. N., Weiland, H. J., Stalder, B., Rest, A., Stubbs, C. W., Anderson, J. P., Chen, T. -W., Clark, P., Do, A., Förster, F., Fulton, M., Gillanders, J., McBrien, O. R., O'Neill, D., Srivastav, S., and Wright, D. E.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The Asteroid Terrestrial impact Last Alert System (ATLAS) system consists of two 0.5m Schmidt telescopes with cameras covering 29 square degrees at plate scale of 1.86 arcsec per pixel. Working in tandem, the telescopes routinely survey the whole sky visible from Hawaii (above $\delta > -50^{\circ}$) every two nights, exposing four times per night, typically reaching $o < 19$ magnitude per exposure when the moon is illuminated and $c < 19.5$ per exposure in dark skies. Construction is underway of two further units to be sited in Chile and South Africa which will result in an all-sky daily cadence from 2021. Initially designed for detecting potentially hazardous near earth objects, the ATLAS data enable a range of astrophysical time domain science. To extract transients from the data stream requires a computing system to process the data, assimilate detections in time and space and associate them with known astrophysical sources. Here we describe the hardware and software infrastructure to produce a stream of clean, real, astrophysical transients in real time. This involves machine learning and boosted decision tree algorithms to identify extragalactic and Galactic transients. Typically we detect 10-15 supernova candidates per night which we immediately announce publicly. The ATLAS discoveries not only enable rapid follow-up of interesting sources but will provide complete statistical samples within the local volume of 100 Mpc. A simple comparison of the detected supernova rate within 100 Mpc, with no corrections for completeness, is already significantly higher (factor 1.5 to 2) than the current accepted rates., Comment: 27 pages, 12 figures. Accepted for publication in PASP on 2020 May 15
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- 2020
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33. Observational constraints on the optical and near-infrared emission from the neutron star-black hole binary merger S190814bv
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Ackley, K., Amati, L., Barbieri, C., Bauer, F. E., Benetti, S., Bernardini, M. G., Bhirombhakdi, K., Botticella, M. T., Branchesi, M., Brocato, E., Bruun, S. H., Bulla, M., Campana, S., Cappellaro, E., Castro-Tirado, A. J., Chambers, K. C., Chaty, S., Chen, T. -W., Ciolfi, R., Coleiro, A., Copperwheat, C. M., Covino, S., Cutter, R., D'Ammando, F., D'Avanzo, P., De Cesare, G., D'Elia, V., Della Valle, M., Denneau, L., De Pasquale, M., Dhillon, V. S., Dyer, M. J., Elias-Rosa, N., Evans, P. A., Eyles-Ferris, R. A. J., Fiore, A., Fraser, M., Fruchter, A. S., Fynbo, J. P. U., Galbany, L., Gall, C., Galloway, D. K., Getman, F. I., Ghirlanda, G., Gillanders, J. H., Gomboc, A., Gompertz, B. P., González-Fernández, C., González-Gaitán, S., Grado, A., Greco, G., Gromadzki, M., Groot, P. J., Gutiérrez, C. P., Heikkilä, T., Heintz, K. E., Hjorth, J., Hu, Y. -D., Huber, M. E., Inserra, C., Izzo, L., Japelj, J., Jerkstrand, A., Jin, Z. P., Jonker, P. G., Kankare, E., Kann, D. A., Kennedy, M., Kim, S., Klose, S., Kool, E. C., Kotak, R., Kuncarayakti, H., Lamb, G. P., Leloudas, G., Levan, A. J., Longo, F., Lowe, T. B., Lyman, J. D., Magnier, E., Maguire, K., Maiorano, E., Mandel, I., Mapelli, M., Mattila, S., McBrien, O. R., Melandri, A., Michałowski, M. J., Milvang-Jensen, B., Moran, S., Nicastro, L., Nicholl, M., Guelbenzu, A. Nicuesa, Nuttal, L., Oates, S. R., O'Brien, P. T., Onori, F., Palazzi, E., Patricelli, B., Perego, A., Torres, M. A. P., Perley, D. A., Pian, E., Pignata, G., Piranomonte, S., Poshyachinda, S., Possenti, A., Pumo, M. L., Quirola-Vásquez, J., Ragosta, F., Ramsay, G., Rau, A., Rest, A., Reynolds, T. M., Rosetti, S. S., Rossi, A., Rosswog, S., Sabha, N. B., Carracedo, A. Sagués, Salafia, O. S., Salmon, L., Salvaterra, R., Savaglio, S., Sbordone, L., Schady, P., Schipani, P., Schultz, A. S. B., Schweyer, T., Smartt, S. J., Smith, K. W., Smith, M., Sollerman, J., Srivastav, S., Stanway, E. R., Starling, R. L. C., Steeghs, D., Stratta, G., Stubbs, C. W., Tanvir, N. R., Testa, V., Thrane, E., Tonry, J. L., Turatto, M., Ulaczyk, K., van der Horst, A. J., Vergani, S. D., Walton, N. A., Watson, D., Wiersema, K., Wiik, K., Wyrzykowski, L., Yang, S., Yi, S. -X., and Young, D. R.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
On 2019 August 14, the LIGO and Virgo interferometers detected a high-significance event labelled S190814bv. Preliminary analysis of the GW data suggests that the event was likely due to the merger of a compact binary system formed by a BH and a NS. ElectromagNetic counterparts of GRAvitational wave sources at the VEry Large Telescope (ENGRAVE) collaboration members carried out an intensive multi-epoch, multi-instrument observational campaign to identify the possible optical/near infrared counterpart of the event. In addition, the ATLAS, GOTO, GRAWITA-VST, Pan-STARRS and VINROUGE projects also carried out a search on this event. Our observations allow us to place limits on the presence of any counterpart and discuss the implications for the kilonova (KN) possibly generated by this NS-BH merger, and for the strategy of future searches. Altogether, our observations allow us to exclude a KN with large ejecta mass $M\gtrsim 0.1\,\mathrm{M_\odot}$ to a high ($>90\%$) confidence, and we can exclude much smaller masses in a subsample of our observations. This disfavours the tidal disruption of the neutron star during the merger. Despite the sensitive instruments involved in the campaign, given the distance of S190814bv we could not reach sufficiently deep limits to constrain a KN comparable in luminosity to AT 2017gfo on a large fraction of the localisation probability. This suggests that future (likely common) events at a few hundreds Mpc will be detected only by large facilities with both high sensitivity and large field of view. Galaxy-targeted observations can reach the needed depth over a relevant portion of the localisation probability with a smaller investment of resources, but the number of galaxies to be targeted in order to get a fairly complete coverage is large, even in the case of a localisation as good as that of this event., Comment: 52 pages, revised version now accepted for publication in A&A. Abstract abridged to meet arXiv requirements
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- 2020
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34. The lowest of the low: discovery of SN 2019gsc and the nature of faint Iax supernovae
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Srivastav, Shubham, Smartt, Stephen J., Leloudas, Giorgos, Huber, Mark E., Chambers, Ken, Malesani, Daniele B., Hjorth, Jens, Gillanders, James H., Schultz, A., Sim, Stuart A., Auchettl, Katie, Fynbo, Johan P. U., Gall, Christa, McBrien, Owen R., Rest, Armin, Smith, Ken W., Wojtak, Radoslaw, and Young, David R.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present the discovery and optical follow-up of the faintest supernova-like transient known. The event (SN 2019gsc) was discovered in a star-forming host at 53\,Mpc by ATLAS. A detailed multi-colour light curve was gathered with Pan-STARRS1 and follow-up spectroscopy was obtained with the NOT and Gemini-North. The spectra near maximum light show narrow features at low velocities of 3000 to 4000 km s$^{-1}$, similar to the extremely low luminosity SNe 2010ae and 2008ha, and the light curve displays a similar fast decline (\dmr $0.91 \pm 0.10$ mag). SNe 2010ae and 2008ha have been classified as type Iax supernovae, and together the three either make up a distinct physical class of their own or are at the extreme low luminosity end of this diverse supernova population. The bolometric light curve is consistent with a low kinetic energy of explosion ($E_{\rm k} \sim 10^{49}$ erg s$^{-1}$), a modest ejected mass ($M_{\rm ej} \sim 0.2$ \msol) and radioactive powering by $^{56}$Ni ($M_{\rm Ni} \sim 2 \times 10^{-3}$ \msol). The spectra are quite well reproduced with radiative transfer models (TARDIS) and a composition dominated by carbon, oxygen, magnesium, silicon and sulphur. Remarkably, all three of these extreme Iax events are in similar low-metallicity star-forming environments. The combination of the observational constraints for all three may be best explained by deflagrations of near $M_{\rm Ch}$ hybrid carbon-oxygen-neon white dwarfs which have short evolutionary pathways to formation., Comment: 12 pages, 5 figures, accepted to ApJL, minor changes to submitted version
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- 2020
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35. Discovering and characterising compact mergers in wide-field surveys
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McBrien, Owen and Smartt, Stephen
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523.8 ,compact mergers ,sky surveys ,binary neutron star mergers - Abstract
This thesis concentrates on efforts to identify and characterize compact mergers involving neutron stars using wide-field survey instruments. With the Panoramic Survey Telescope and Rapid Response System (Pan-STARRS) and the Asteroid Terrestrial-impact Last Alert System (ATLAS), searches for compact mergers, including kilonovae, have been performed. The Pan-STARRS search identified two rapidly evolving transients with similar decline rates to the first kilonova, AT2017gfo, in PS15cey and PS17cke. While model fits of black hole-neutron star mergers can match the peak luminosity of PS15cey, a kilonova interpretation is less likely than a rapidly evolving supernova. PS17cke may be a plausible kilonova candidate, however, based on supporting modelling. The ATLAS search has returned no plausible kilonova candidates, but has identified a unique optical transient in AT2018kzr whose peak luminosity and rapid decline are difficult to describe using a traditional Nickel-56 driven explosion models. This necessitates the inclusion of an additional powering source, such as the spin-down of a magnetic neutron star remnant, to provide a plausible model fit to the bolometric lightcurve. Spectral modelling suggests the object is characterised by intermediate mass elements (including oxygen, silicone and magnesium) which disfavours a neutron star-neutron star merger scenario, but is consistent with predictions of white dwarfneutron star mergers. The lack of a kilonova detection by ATLAS has prompted the development of an efficiency simulation to understand the challenges of observing rapidly evolving and intrinsically faint transients with all-sky survey telescopes. Such a simulation has been used to constrain the volumetric rate of AT2017gfo-like transients in the local universe, with the results being consistent with other optically-derived rates estimates and rate of binary neutron star mergers measured gravitational wave observatories. Given the available information, it is predicted ATLAS will need to continue observing for at least a decade in order to observe a kilonova.
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- 2021
36. Gender Stereotypes in Education: Policies and Practices to Address Gender Stereotyping across OECD Education Systems. OECD Education Working Papers. No. 271
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Organisation for Economic Cooperation and Development (OECD) (France), Brussino, Ottavia, and McBrien, Jody
- Abstract
In spite of advances in recognising that girls and boys, and women and men, do not have to be bounded by traditional roles, gender stereotypes persist in education and beyond. Children and youth are affected by gender stereotypes from the early ages, with parental, school, teacher and peer factors influencing the way students internalise their gender identities. As such, not only is intervening in pre-primary education necessary, but also measures at the primary and secondary levels are key to eradicate gender stereotypes and promote gender equality. Based on the analytical framework developed by the OECD Strength through Diversity project, this paper provides an overview of gender stereotyping in education, with some illustrations of policies and practices in place across OECD countries, with a focus on curriculum arrangements, capacity-building strategies and school-level interventions in primary and secondary education.
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- 2022
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37. Impact of Socioeconomic Status, Race and Ethnicity, and Geography on Prenatal Detection of Hypoplastic Left Heart Syndrome and Transposition of the Great Arteries
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Krishnan, Anita, Jacobs, Marni B, Morris, Shaine A, Peyvandi, Shabnam, Bhat, Aarti H, Chelliah, Anjali, Chiu, Joanne S, Cuneo, Bettina F, Freire, Grace, Hornberger, Lisa K, Howley, Lisa, Husain, Nazia, Ikemba, Catherine, Kavanaugh-McHugh, Ann, Kutty, Shelby, Lee, Caroline, Lopez, Keila N, McBrien, Angela, Michelfelder, Erik C, Pinto, Nelangi M, Schwartz, Rachel, Stern, Kenan WD, Taylor, Carolyn, Thakur, Varsha, Tworetzky, Wayne, Wittlieb-Weber, Carol, Woldu, Kris, Donofrio, Mary T, Craft, Mary, Gramse, Heather, Moon-Grady, Anita, Lee, Wesley, Park, Dawn, and Wiener, Alysia
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Clinical Research ,Cardiovascular ,Pediatric ,Heart Disease ,Prevention ,Good Health and Well Being ,Cohort Studies ,Ethnicity ,Female ,Geography ,Humans ,Hypoplastic Left Heart Syndrome ,Male ,Racial Groups ,Retrospective Studies ,Social Class ,Transposition of Great Vessels ,congenital heart disease ,fetal development ,social determinants of health ,Fetal Heart Society ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services ,Cardiovascular System & Hematology - Abstract
BackgroundPrenatal detection (PND) has benefits for infants with hypoplastic left heart syndrome (HLHS) and transposition of the great arteries (TGA), but associations between sociodemographic and geographic factors with PND have not been sufficiently explored. This study evaluated whether socioeconomic quartile (SEQ), public insurance, race and ethnicity, rural residence, and distance of residence (distance and driving time from a cardiac surgical center) are associated with the PND or timing of PND, with a secondary aim to analyze differences between the United States and Canada.MethodsIn this retrospective cohort study, fetuses and infants
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- 2021
38. Building a Data Bridge: Policies, Structures, and Governance Integrating Primary Care Into the Public Health Response to COVID-19
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Leslie, Myles, Hansen, Brian, Abboud, Rida, Claussen, Caroline, McBrien, Kerry, Hu, Jia, Ward, Rick, and Aghajafari, Fariba
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Epidemics -- Control -- Canada ,Medical cooperation -- Methods ,Electronic data processing -- Methods ,Primary health care -- Methods -- Laws, regulations and rules ,Public health administration -- Methods -- Laws, regulations and rules ,Government regulation ,Health ,Science and technology - Abstract
PURPOSE The effective integration of primary care into public health responses to the COVID-19 pandemic, particularly through data sharing, has received some attention in the literature. However, the specific policies and structures that facilitate this integration are understudied. This paper describes the experiences of clinicians and administrators in Alberta, Canada as they built a data bridge between primary care and public health to improve the province's community-based response to the pandemic. METHODS Fifty-seven semistructured qualitative interviews were conducted with a range of primary care and public health stakeholders working inside the Calgary Health Zone. Interpretive description was used to analyze the interviews. RESULTS SARS-CoV-2 test results produced by the local public laboratory were, initially, only available to central public health clinicians and not independent primary care physicians. This enabled centrally managed contact tracing but meant primary care physicians were unaware of their patients' COVID-19 status and unable to offer in-community follow-up care. Stakeholders from both central public health and independent primary care were able to leverage a policy commitment to the Patient Medical Home (PMH) care model, and a range of existing organizational structures, and governance arrangements to create a data bridge that would span the gap. CONCLUSIONS Primary care systems looking to draw lessons from the data bridge's construction may consider ways to: leverage care model commitments to integration and adjust or create organization and governance structures which actively draw together primary care and non-primary care stakeholders to work on common projects. Such policies and structures develop trusting relationships, open the possibility for champions to emerge, and create the spaces in which integrative improvisation can take place. Key words: primary care; integration; public health response; data sharing; COVID-19; qualitative; primary care network, INTRODUCTION The vast majority of COVID-19 cases and their 'long COVID' sequalae (1,2) have been managed in the community by primary care teams. (3,4) As much as those primary care [...]
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- 2023
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39. Spatiotemporal distribution of power outages with climate events and social vulnerability in the USA
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Vivian Do, Heather McBrien, Nina M. Flores, Alexander J. Northrop, Jeffrey Schlegelmilch, Mathew V. Kiang, and Joan A. Casey
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Science - Abstract
Abstract Power outages threaten public health. While outages will likely increase with climate change, an aging electrical grid, and increased energy demand, little is known about their frequency and distribution within states. Here, we characterize 2018–2020 outages, finding an average of 520 million customer-hours total without power annually across 2447 US counties (73.7% of the US population). 17,484 8+ hour outages (a medically-relevant duration with potential health consequences) and 231,174 1+ hour outages took place, with greatest prevalence in Northeastern, Southern, and Appalachian counties. Arkansas, Louisiana, and Michigan counties experience a dual burden of frequent 8+ hour outages and high social vulnerability and prevalence of electricity-dependent durable medical equipment use. 62.1% of 8+ hour outages co-occur with extreme weather/climate events, particularly heavy precipitation, anomalous heat, and tropical cyclones. Results could support future large-scale epidemiology studies, inform equitable disaster preparedness and response, and prioritize geographic areas for resource allocation and interventions.
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- 2023
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40. Disparities in preterm birth following the July 1995 Chicago heat wave
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Gordon, Milo, Casey, Joan A., McBrien, Heather, Gemmill, Alison, Hernández, Diana, Catalano, Ralph, Chakrabarti, Suman, and Bruckner, Tim
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- 2023
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41. CD8+ lymphocytes do not impact SIV reservoir establishment under ART
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Statzu, Maura, Jin, Wang, Fray, Emily J., Wong, Andrew Kam Ho, Kumar, Mithra R., Ferrer, Elizabeth, Docken, Steffen S., Pinkevych, Mykola, McBrien, Julia B., Fennessey, Christine M., Keele, Brandon F., Liang, Shan, Harper, Justin L., Mutascio, Simona, Franchitti, Lavinia, Wang, Hong, Cicetti, Davide, Bosinger, Steven E., Carnathan, Diane G., Vanderford, Thomas H., Margolis, David M., Garcia-Martinez, J. Victor, Chahroudi, Ann, Paiardini, Mirko, Siliciano, Janet, Davenport, Miles P., Kulpa, Deanna A., Siliciano, Robert S., and Silvestri, Guido
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- 2023
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42. The 2021 Texas Power Crisis: distribution, duration, and disparities
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Flores, Nina M., McBrien, Heather, Do, Vivian, Kiang, Mathew V., Schlegelmilch, Jeffrey, and Casey, Joan A.
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- 2023
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43. Social and Emotional Learning (SEL) of Newcomer and Refugee Students: Beliefs, Practices and Implications for Policies across OECD Countries. OECD Education Working Papers. No. 266
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Organisation for Economic Cooperation and Development (OECD) (France), Directorate for Education and Skills and McBrien, Jody
- Abstract
Social and emotional learning (SEL) strengthens students' abilities to regulate their emotions, thoughts, and behaviours and to interact successfully with others. There are an array of important social and emotional skills (SES): goal-setting, working to one's potential, resilience, creativity, perseverance, problem solving, and caring about the welfare of others, among them. All students need SEL, but newcomer and refugee students may have particular challenges requiring SES. The beginning of this paper examines the current situation of refugee and newcomer students in OECD countries, SEL, its frameworks and skills and how they apply to newcomer and refugee students. The paper concludes with an examination of SEL policies and practices for newcomer and refugee students in OECD countries.
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- 2022
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44. The bacterial and fungal communities in the airways of adults with asthma and eosinophilic lung diseases
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McBrien, Claire Nichola, Moffatt, Miram, Menzies-Gow, Andrew, and Cookson, William
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Asthma is the most common long-term respiratory condition, but its aetiology is not fully understood. The incidence has increased alongside urbanisation and altered microbial exposure patterns. The respiratory tract's bacterial communities (microbiota) undergo dysbiosis in asthma. Eosinophilic inflammation, common in asthma, also occurs in fungal infections and eosinophilic lung diseases (ELDs) including Chronic Eosinophilic Pneumonia (CEP). The CEP microbiome has not yet been described and there are few studies of respiratory fungal communities (mycobiota) in health or disease. The main objective of this thesis was to describe the respiratory microbiota and mycobiota in asthma, ELDs and healthy controls, through two cross-sectional bronchoscopy studies: 1) A multi-centre study of asthmatics and controls (Celtic Fire); 2) A single-centre study of subjects with ELDs and controls (Bronchoscopic evaluation of the Eosinophilic Airway Microbiome, BEAM). Oropharyngeal (throat) swab (OTS) samples (N = 130) and left lower lobe (LLL) brushes (N = 131) were obtained from 131 subjects (Celtic Fire: 66 asthmatics, 44 controls; BEAM: 11 subjects with ELDs, 10 controls). In Celtic Fire additional brushings were obtained when feasible. Samples underwent DNA extraction. Bacterial DNA was quantified and sequenced using 16S rRNA gene qPCR and 16S sequencing (Illumina MiSeq) respectively. Selected samples underwent comparable processes regarding fungi: 18S rRNA gene qPCR and ITS2 sequencing. Sequences underwent pre-processing using Quantitative Insights Into Microbial Ecology and analysis in R. Within individuals, left upper lobe (LUL) and LLL brushes were highly similar. In both studies OTS samples contained c. 100 times more bacterial and fungal DNA than LLL brushes. Upper respiratory tract (URT) bacterial communities were similar to the lower respiratory tract (LRT), but fungal sequencing results varied greatly between URT and LRT. Numerous operational taxonomic units (OTUs) were differentially abundant according to case-control status and other clinical variables e.g. sex, corticosteroid use and smoking history. Analyses have provided insights into relationships between microbes, host and disease.
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- 2020
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45. Cervical Cancer Screening by Refugee Category in a Refugee Health Primary Care Clinic in Calgary, Canada, 2011–2016
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Whalen-Browne, Molly, Talavlikar, Rachel, Brown, Garielle, McBrien, Kerry, Wiedmeyer, Mei-ling, Norrie, Eric, and Fabreau, Gabriel
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- 2022
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46. LAW FARE: The twisted logic of Trump's cries of legal corruption
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McBrien, Tyler
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Presidential candidates -- Political activity ,Justice, Administration of -- Political aspects -- United States - Abstract
LAST YEAR, Manhattan District Attorney Alvin Bragg unsealed a criminal indictment against former President Donald Trump for 34 counts of falsifying business records. To right-wing pundits, this amounted to a [...]
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- 2024
47. SN2018kzr: a rapidly declining transient from the destruction of a white dwarf
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McBrien, Owen R., Smartt, Stephen J., Chen, Ting-Wan, Inserra, Cosimo, Gillanders, James H., Sim, Stuart A., Jerkstrand, Anders, Rest, Armin, Valenti, Stefano, Roy, Rupak, Gromadzki, Mariusz, Taubenberger, Stefan, Flörs, Andreas, Huber, Mark E., Chambers, Ken C., Gal-Yam, Avishay, Young, David R., Nicholl, Matt, Kankare, Erkki, Smith, Ken W., Maguire, Kate, Mandel, Ilya, Prentice, Simon, Rodríguez, Ósmar, Garcia, Jonathon Pineda, Gutiérrez, Claudia P., Galbany, Lluís, Barbarino, Cristina, Clark, Peter S. J., Sollerman, Jesper, Kulkarni, Shrinivas R., De, Kishalay, Buckley, David A. H., and Rau, Arne
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present SN2018kzr, the fastest declining supernova-like transient, second only to the kilonova, AT2017gfo. SN2018kzr is characterized by a peak magnitude of $M_r = -17.98$, peak bolometric luminosity of ${\sim} 1.4 \times 10^{43}$erg s$^{\mathrm{-1}}$ and a rapid decline rate of $0.48 \pm 0.03$ mag day$^{\textrm{-1}}$ in the $r$ band. The bolometric luminosity evolves too quickly to be explained by pure $^{\mathrm{56}}$Ni heating, necessitating the inclusion of an alternative powering source. Incorporating the spin-down of a magnetized neutron star adequately describes the lightcurve and we estimate a small ejecta mass of $M_\mathrm{ej} = 0.10 \pm 0.05$ $\textrm{M}_{\odot}$. Our spectral modelling suggests the ejecta is composed of intermediate mass elements including O, Si and Mg and trace amounts of Fe-peak elements, which disfavours a binary neutron star merger. We discuss three explosion scenarios for SN2018kzr, given the low ejecta mass, intermediate mass element composition and the high likelihood of additional powering - core collapse of an ultra-stripped progenitor, the accretion induced collapse of a white dwarf and the merger of a white dwarf and neutron star. The requirement for an alternative input energy source favours either the accretion induced collapse with magnetar powering or a white dwarf - neutron star merger with energy from disk wind shocks., Comment: 11 pages, 5 figures, 3 tables Accepted by ApJL on 2019 October 15
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- 2019
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48. Up-to-date on cancer screening among Ontario patients seen by walk-in clinic physicians: A retrospective cohort study
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Lofters, Aisha, Salahub, Christine, Austin, Peter C., Bai, Li, Berthelot, Simon, Bhatia, R. Sacha, Desveaux, Laura, Ivers, Noah M., Kiran, Tara, Maclure, Malcolm, Martin, Danielle, McBrien, Kerry A., McCracken, Rita, Paterson, J. Michael, Rahman, Bahram, Shuldiner, Jennifer, Tadrous, Mina, Thakkar, Niels, and Lapointe-Shaw, Lauren
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- 2023
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49. Search for transient optical counterparts to high-energy IceCube neutrinos with Pan-STARRS1
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Kankare, E., Huber, M., Smartt, S. J., Chambers, K., Smith, K. W., McBrien, O., Chen, T. -W., Flewelling, H., Lowe, T., Magnier, E., Schultz, A., Waters, C., Wainscoat, R. J., Willman, M., Wright, D., Young, D., Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Alispach, C., Altmann, D., Andeen, K., Anderson, T., Ansseau, I., Anton, G., Argüelles, C., Auffenberg, J., Axani, S., Backes, P., Bagherpour, H., Bai, X., Barbano, A., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Becker, K. -H., Tjus, J. Becker, BenZvi, S., Berley, D., Bernardini, E., Besson, D. Z., Binder, G., Bindig, D., Blaufuss, E., Blot, S., Bohm, C., Börner, M., Böser, S., Botner, O., Bourbeau, E., Bourbeau, J., Bradascio, F., Braun, J., Bretz, H. -P., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Carver, T., Chen, C., Cheung, E., Chirkin, D., Clark, K., Classen, L., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Dave, P., de André, J. P. A. M., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., az-Vélez, J. C. Dí, Dujmovic, H., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eller, P., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Franckowiak, A., Friedman, E., Fritz, A., Gaisser, T. K., Gallagher, J., Ganster, E., Garrappa, S., Gerhardt, L., Ghorbani, K., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Gonzalez, J. G., Grant, D., Griffith, Z., Günder, M., Gündüz, M., Haack, C., Hallgren, A., Halve, L., Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Helbing, K., Hellauer, R., Henningsen, F., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Huang, F., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jacobi, E., Japaridze, G. S., Jeong, M., Jero, K., Jones, B. J. P., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karl, M., Karle, A., Katz, U., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Krückl, G., Kulacz, N., Kunwar, S., Kurahashi, N., Kyriacou, A., Labare, M., Lanfranchi, J. L., Larson, M. J., Lauber, F., Lazar, J. P., Leonard, K., Leuermann, M., Liu, Q. R., Lohfink, E., Mariscal, C. J. Lozano, Lu, L., Lucarelli, F., Lünemann, J., Luszczak, W., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mallot, K., Mancina, S., Mariş, I. C., Maruyama, R., Mase, K., Maunu, R., Meagher, K., Medici, M., Medina, A., Meier, M., Meighen-Berger, S., Menne, T., Merino, G., Meures, T., Miarecki, S., Micallef, J., Momenté, G., Montaruli, T., Moore, R. W., Moulai, M., Nagai, R., Nahnhauer, R., Nakarmi, P., Naumann, U., Neer, G., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Pollmann, A. Obertacke, Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Park, N., Peiffer, P., Heros, C. Pérez de los, Pieloth, D., Pinat, E., Pizzuto, A., Plum, M., Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Reimann, R., Relethford, B., Renzi, G., Resconi, E., Rhode, W., Richman, M., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Safa, I., Herrera, S. E. Sanchez, Sandrock, A., Sandroos, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, M., Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schumacher, L., Sclafani, S., Seckel, D., Seunarine, S., Silva, M., Snihur, R., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., Stamatikos, M., Stanev, T., Stasik, A., Stein, R., Stettner, J., Steuer, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strotjohann, N. L., Stuttard, T., Sullivan, G. W., Sutherland, M., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tomankova, L., Tönnis, C., Toscano, S., Tosi, D., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Elorrieta, M. A. Unland, Usner, M., Vandenbroucke, J., Van Driessche, W., van Eijk, D., van Eijndhoven, N., Vanheule, S., van Santen, J., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandkowsky, N., Watson, T. B., Weaver, C., Weiss, M. J., Weldert, J., Wendt, C., Werthebach, J., Westerhoff, S., Whelan, B. J., Whitehorn, N., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woschnagg, K., Wrede, G., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., and Nordin, J.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
In order to identify the sources of the observed diffuse high-energy neutrino flux, it is crucial to discover their electromagnetic counterparts. IceCube began releasing alerts for single high-energy ($E > 60$ TeV) neutrino detections with sky localisation regions of order 1 deg radius in 2016. We used Pan-STARRS1 to follow-up five of these alerts during 2016-2017 to search for any optical transients that may be related to the neutrinos. Typically 10-20 faint ($m < 22.5$ mag) extragalactic transients are found within the Pan-STARRS1 footprints and are generally consistent with being unrelated field supernovae (SNe) and AGN. We looked for unusual properties of the detected transients, such as temporal coincidence of explosion epoch with the IceCube timestamp. We found only one transient that had properties worthy of a specific follow-up. In the Pan-STARRS1 imaging for IceCube-160427A (probability to be of astrophysical origin of $\sim$50 %), we found a SN PS16cgx, located at 10.0' from the nominal IceCube direction. Spectroscopic observations of PS16cgx showed that it was an H-poor SN at z = 0.2895. The spectra and light curve resemble some high-energy Type Ic SNe, raising the possibility of a jet driven SN with an explosion epoch temporally coincident with the neutrino detection. However, distinguishing Type Ia and Type Ic SNe at this redshift is notoriously difficult. Based on all available data we conclude that the transient is more likely to be a Type Ia with relatively weak SiII absorption and a fairly normal rest-frame r-band light curve. If, as predicted, there is no high-energy neutrino emission from Type Ia SNe, then PS16cgx must be a random coincidence, and unrelated to the IceCube-160427A. We find no other plausible optical transient for any of the five IceCube events observed down to a 5$\sigma$ limiting magnitude of $m \sim 22$ mag, between 1 day and 25 days after detection., Comment: 20 pages, 6 figures, accepted to A&A
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- 2019
- Full Text
- View/download PDF
50. The primary care COVID-19 integrated pathway: a rapid response to health and social impacts of COVID-19
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Fariba Aghajafari, Brian Hansen, Kerry McBrien, Myles Leslie, Alexandra Chiew, Rick Ward, Bing Li, and Jia Hu
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Primary care ,Public health ,COVID 19 ,Clinical care pathway ,Medicine (General) ,R5-920 - Abstract
Abstract Background The first wave of COVID-19 in Calgary, Alberta accelerated the integration of primary care with the province’s centrally managed health system. This integration aimed to deliver wraparound in-community patient care through two interventions that combined to create the COVID-19 Integrated Pathway (CIP). The CIP’s interventions were: 1) a data sharing platform that ensured COVID-19 test results were directly available to family physicians (FPs), and 2) a clinical algorithm that supported FPs in delivering in-community follow up to improve patient outcomes. We describe the CIP function and its capacity to facilitate FP follow-up with COVID-19 patients and evaluate its impact on Emergency Department (ED) visits and hospitalization. Method We generated descriptive statistics by analyzing data from a Calgary Zone hub clinic called the Calgary COVID-19 Care Clinic (C4), provincially maintained records of hospitalization, ED visits, and physician claims. Results Between Apr. 16 and Sep. 27, 2020, 7289 patients were referred by the Calgary Public Health team to the C4 clinic. Of those, 48.6% were female, the median age was 37.4 y. 97% of patients had at least one visit with a healthcare professional, where follow-up was conducted using the CIP’s algorithm. 5.1% of patients visited an ED and 1.9% were hospitalized within 30 days of diagnosis. 75% of patients had a median of 4 visits with their FP. Discussion Our data suggest that information exchange between Primary Care (PC) and central systems facilitates primary care-based management of patients with COVID-19 in the community and has potential to reduce acute care visits.
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- 2022
- Full Text
- View/download PDF
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