1. High risk genotypes for celiac disease
- Author
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Françoise Clerget-Darpoux, Bouguerra F, Kastally R, Semana G, Mc, Babron, Debbabi A, Bennaceur B, and Jf, Eliaou
- Subjects
Male ,Celiac Disease ,Adolescent ,Genotype ,Risk Factors ,Child, Preschool ,HLA-DQ Antigens ,Humans ,Infant ,Female ,Child ,Alleles - Abstract
It is known that celiac disease is strongly associated with an HLA class II component and that most patients carry the dimer DQA1*0501, DQB1*0201. We show in this study that the risk for a carrier of this heterodimer is independent from the number of possible heterodimers, from whether DQA1*0501 and DQB1*0201 are in cis or trans position and from the number of DQA1*0501 (one or two) but strongly depends on the number of DQB1*0201. In the Tunisian population we studied, the risk of developing celiac disease is estimated to be 6.8 times greater for those having a double dose of DQB1*0201 than for other dimer carriers. We replicated this result in published data of four other populations (Italy, Czekoslovakia, United Kingdom, Norway).
- Published
- 1994