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1. Likely clinical depression and HIV-related decline in antiretroviral therapy untreated women who seroconverted during participation in microbicide trials in sub-Saharan Africa

Author

Rael, Christine T, Roberts, Sarah, Ibitoye, Mbolaji, Gorbach, Pamina M, Palanee-Phillips, Thesla, Harkoo, Ishana, Mbilizi, Yamikani, Panchia, Ravindre, Siva, Samantha, Tembo, Tchangani, Akello, Carolyne Agwau, Balkus, Jennifer, Riddler, Sharon, and Carballo-Diéguez, Alex

Subjects
Infectious Diseases, HIV/AIDS, Clinical Research, Behavioral and Social Science, Depression, Clinical Trials and Supportive Activities, Brain Disorders, Mental Health, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Good Health and Well Being, Anti-HIV Agents, Anti-Infective Agents, Cross-Sectional Studies, Female, HIV Infections, Humans, Male, Viral Load, Clinical Sciences, Medical Microbiology, Public Health and Health Services, Public Health
Abstract

Depression worsens HIV outcomes in populations treated with antiretroviral therapy (ART) medications. Data are limited on the relationship between depression and HIV in untreated populations in sub-Saharan Africa. We aimed to identify associations between likely clinical depression, alcohol use, social support by partners, and HIV viral load (VL) among ART untreated women who recently became HIV positive and enrolled in the Microbicide Trials Network (MTN)-015 study. Analyses used cross-sectional data collected at baseline in MTN-015. Participants in this analysis (N = 190) enrolled from other MTN trials were not receiving ART and provided data on their HIV disclosure status to their husband or male partner and alcohol use behavior. The dependent variable, VL, was categorized as: low (≤400 RNA copies/mL; 9.1% of participants), medium (401-20,000 RNA copies/mL; 48.8%), and high (>20,000 RNA copies/mL; 42.0%). Depression was assessed using eight items from Hopkins Symptom Checklist; a cutoff of ≥1.75 indicated likely clinical depression. Independent variables with a significance of p ≤ 0.05 in unadjusted regressions were included in a regression adjusted for age, education, and time since seroconversion. Depressive symptoms were positively associated with high VL, in the adjusted regression (OR = 1.80; 95% CI = 1.07-3.01). Results suggest that likely having clinical depression may have a biological relationship with HIV disease progression.

Published
2021

2. Safety, uptake, and use of a dapivirine vaginal ring for HIV-1 prevention in African women (HOPE): an open-label, extension study

Author

Aanyu, Dorothy, Abima, John, Abullarade, Janne, Agarwal, Priyanka, Ahluwalia, Surabhi, Akasiima, Simon Africa, Akello, Carolyne Agwau, Albert, Samuel, Alphale, Motsamai, Alphonse, Calins, Apeduno, Lucy, Aranda, Sara, Aridor, Orly, Arnolds, Shakeera, Asiimwe, Prossy, Atujuna, Millicent, Atwebembere, Didas, Baboolall, Lakshmi, Badana, Kiran, Baeten, Jared M., Balamusani, David, Balán, Iván C., Banda, Gabriel, Banda, Towera Whitney, Baugh, Jennifer, Baziira, James Amos, Beamer, May, Bebeza, Sivuyisiwe Asanda, Bekker, Linda-Gail, Bell, Ian, Bemer, Meagan, Berman, Richard, Berthiaume, Jennifer, Bezak, Linda, Bhagwandin, Yashveer, Bhayat, Hassen Anwar, Bhengu, Nokulunga, Bhengu, Sonto, Bhoola, Aruna, Biira, Florence Asiimwe, Bittoni, Daniel, Black, Roberta, Blose, Nombuso Jacqueline, Boks, Pearl, Bolton, Stephen Gordon, Botya, Phathiswa, Brown, Amanda, Brown, Elizabeth, Brown, Helen, Bruce, Robyn Helen, Bukenya, Luke Erismus, Bukirwa, Aidah, Bunge, Katherine, Bunts, Lisa, Buthelezi, Fezile, Buthelezi, Mbongeleni William, Buthelezi, Samkelisiwe Dumisile, Byogero, Rose, Byroo, Samiksha, Byuma, Robert, Carstens, Johanna Albertha, Carter, Allison, Cassim, Nazneen, Cebekhulu, Busisiwe, Cele, Bongekile, Cele, Dolly Judith, Cele, Phindile, Cele, Simangele, Cele, Sithabile, Chadza, Mary, Chakhtoura, Nahida, Chapdu, Claire, Chareka, Gift Tafadzwa, Chasakara, Charles, Chatani-Gada, Manju, Chetty, Diana, Chidanyika, Mary, Chifambi, Tafadzwa Tariro Lisa, Chihota, Emelder, Chikono, Sungano, Chikonyora, Anesu, Chikukwa, Brett Dzidzai, Chin, Craig, Chindevu, Mary, Chinula, Lameck, Chinyanda, Tendai Blessing, Chirenda, Thandiwe Hilda, Chirenje, Zvavahera Mike, Chirisa, Chiedza, Chisale, Patience, Chishanga, Angela, Chitambo, Tobias, Chitema, Fred, Chithila, Flora, Chitowa, Tinei Helen, Chitsinde, Catherine, Chitsulo, Gladys, Chitukuta, Miria, Chiveso, Spiwe, Chome, Nelecy, Chonco, Phumelele Fortune, Christopher, Emily, Chunderduri, Kerusha, Cibi, Vutomi, Cleland, Naana, Coba, Thobeka, Cobbing, Mandy Rae, Collins, Clare, Comer, Kim, Cozzi, Shameen, Crida, Danielle, Dadabhai, Sufia, Daki, Thembakazi, Danster, Nwabisa, Dassaye, Reshmi, David, Renita, Davis, Jontraye M., Dawood, Sumaya, Deb, Pallabi, Degnam, Leslie, Derrick, Tiffany Sharron, Devlin, Bríd Teresa, Dezzutti, Charlene, Dhlakama, Patricia Mae, Dias, Lorna, Dimairo, Jean Chivoniso, Dinnie, Elaine, Dlabanta, Avile, Dladla, Msizi, Dladla, Thandeka Immaculate, Dlungele, Andile Princess, Dolezal, Curtis, Donaty, Kristine, Dott, Clare, Dubbs, Jenna, Dubula-Majola, Vuyiseka, Dukwe, Pamella, Duma, Cebo Ivan, Duma, Portia Ignatia Makhosazana, Duma, Promise, Duncan, Vimbai Kudzanai, Duran, Luis, Dyabeni, Lindelwa, Edwards, Andrew, Etikala, Radhika, Etima, Juliane, Fairlie, Lee, Fischer, Henry, Fitzpatrick, Jacqueline, Fleurs, Llewellyn, Fowler, Mary Glenn, Freeman, Lester, Gaffoor, Zakir, Gama, Lizzy, Garcia, Morgan, Garg, Anita, Gatsi, Vanesa Margret, Gcwensa, Clifford, Gebashe, Emmanuel Lwandile, Geduld, Samantha, Gelant, Jennipher, Germuga, Donna, Ggita, Joseph, Giguere, Rebecca, Godo, Lucy, Goetz, B. Jay, Gogo, Litha, Goliati, Esther, Gondwe, Daniel Kondwani, Gordon, Kelley C., Goreraza, Rodney, Gounden, Jayandree, Govender, Dhevium, Govender, Justin Sivalingum, Govender, Nerusha, Govender, Subramonien, Govender, Vaneshree, Gqwara, Nonkululeko Nosipho, Gravelle, Anisa (Tracy), Guga, Phindile, Guma, Victor, Gumede, Delisile Zilungile, Gumede, Sibusiso, Gumede, Thembelihle, Gumede, Thobeka Winifred, Gundani, Orgrah, Gunnam, Ravi, Gupta, Rahul, Gwande, Mirriam, Gxako, Xolani, Hall, Kim, Hall, Wayne, Hargrave, Perry, Harkoo, Ishana, Harrell, Tanya, Heaps, Amy L., Hendricks, Simone Lara, Hendrix, Craig W., Hlabisa, Bongeka, Hlabisa, Lungile Bongeka, Hlahla, Kudzai, Hlela, Thulebona Martin, Hobongwana, Thandiwe, Horn, Eva, Howard, Ridley, Huang, Haixiao, Hunidzairia, Portia, Hurbans, Nivriti, Husnik, Marla, Hwehwe, Tendai Doreen, Imamdin, Rabia, Ismail, Amina, Jacobs, Ebrahiema, Jacobson, Cindy, Jacques, Ashleigh Catherine, Jamabya, Jane, James, Grace, Janse van Rensburg, Karla, Jaya, Ziningi Nobuhle, Jeenarain, Nitesha, Jennings, Lauren, Jiang, Haoping, Jiang, Ning, Jiao, Yuqing, Jijana, Nwabisa Laurianne, Jokoniya, Godfrey, Jones, Judith, Kabasonga, Mildred, Kabenge, Daniel Kizza, Kabwigu, Samuel, Kachale, Evans, Kachenjera, Lonely, Kachingamire, Fiona, Kachipapa, Emma, Kadiwa, Mary, Kadyamusuma, McLoddy, Kafufu, Bosco, Kagwa, Mary Mukasa, Kajura-Manyindo, Clare, Kakayi, Brenda Catherine, Kaliwo, Victoria, Kalonji, Dishiki Jenny, Kamanga, Nyasha Elizabeth, Kamira, Betty, Kampangire, Zerif, Kamwana, Getrude, Kamya, Justine, Kapa, La-Donna, Karugaba, Patrick, Kasambara, Khumbo, Kassim, Priya, Kassim, Sheetal, Katana, Milly, Katongole, Francis, Katongole, Sulaiman, Katsis, Alexis, Katumbi, Chaplain, Katz, Ariana W.K., Kawanje, Edmore, Kawuma, Caroline Nassozi, Kayongo, Sowedi, Kekana, Emily, Kemigisha, Doreen, Khanyile, Siphosihle, Khanyisile, Nombuso Happiness, Khaya, Babalwa, Khiya, Noluthando, Khoza, Norah Ntombikayise, Khumalo, Thembisile, Khwela, Christina, Khwela, Zamo, Kibiribiri, Edith, Kibirige, Ismael, Kiiza, Beatrice, Kikonyogo, Florence Sempa, Kin, Melissa, Kirkwood, Catherine, Kistnasami, Girisha, Kiweewa, Flavia Matovu, Kiweewa, Max, Konatham, Deepika, Kubheka, Lungile, Kufakunesu, Terrence, Kumwenda, Phaleda, Kumwenda, Wiza Wisdom Isaac, Kush, Maura, Kutner, Bryan A., Kwatsha, Ntomboxolo, Kwedza, Rosper, Kyomukama, Erinah, Lands, Debra, Langa, Phumelele Nokuthula, Lebeta, Kalkidan, Lentz, Cody, Leremi, Brendley Tebogo, Leszczewski, Michelle, Levy, Lisa, Livant, Edward, Livant, Ted, Lukas, Irene, Mabanga, Lungile Pearl, Mabaso, Nomusa, Machisa, Vimbainashe, Maddox, Toni M., Madlala, Bernadette, Magobiane, Nocwaka, Magolela, Melda, Maguramhinga, Fungai, Magwaza, Phumzile Desiree, Maharaj, Keshnee, Mahed, Ferial, Mahlase, Tankiso Vuyiswa, Maila, Moshukutjoane Lebogang, Makala, Yvonne, Makamure, Patrick, Makanani, Bonus, Makgoka, Kgabo Phineas, Makhamba, Pamela, Makhanya, Nompumelelo, Makondo, Rulani, Makoni, Rujeko, Makooka, Henry, Makunganya, Jennie, Makwenda, Sibongile, Malan, Gakiema, Malemia, Agnes, Malherbe, Mariette, Malunga, Faith, Mamba Nhassengo, Temantfulini, Mampa, Mogau, Mamvura, Tendai Karen, Manengamambo, Elmah, Mangove, Loreen Zandile, Mangxilana, Nomvuyo Thelma, Manjera, Tsungai Patience, Mans, Winifred Elizabeth, Mansoor, Leila, Maoko, Memory, Mapfunde, Annie, Maphumulo, Nonhlanhla Yvonne, Martinson, Francis E.A., Maruwo, Abel, Marx, Emmerentia Yvonne, Marzinke, Mark A., Masango, Moira, Mashego, Mmathabo Nnana, Mashinini, Gwendoline Thotele Refilwe, Masuko, Shingirayi Irene, Matambanadzo, Kudzai Viviana, Mathebula, Florence Tintswalo, Mathipa, Matheus, Matsa, Jacob Munyaradzi, Matta, Eleanor Agnes, Matubu, Allen Taguma, Mavundla, Ayanda Comfort, Mavundla, Sandile, Mawindo, Billy, Mayani, Josiah, Mayanja, Emmanuel, Mayekiso, Nombongo, Mayisela, Nonkululeko Precious, Mayo, Ashley J., Mbabali, Mary Speciosa, Mbanjwa, Nonhlakanipho Masibonge Gciniwe, Mbatha, Constance Seanokeng, Mbatha, Nomcedo Janice, Mbewe, Dorica, Mbichila, Tinkhani, Mbilizi, Yamikani Rose, Mbokazi, Sithokoza, Mbwerera, Mwandifitsa, Mchunu, Zethu, McKinstry, Laura, Mdlongwa, Bongiwe, Mellors, John W., Meyiwa, Sihle Perfect, Mgodi, Nyaradzo Mavis, Mhizha, Erasmus Samuel, Mhlanga, Felix, Mhlanga, Nomsa Sibongile, Mirembe, Brenda Gail, Mirembe, Dorothy, Mkandawire, Fumbani, Mkhabela, Ntombizethu Hazel, Mkhize, Baningi, Mkhize, Princess Hlengiwe, Mkhize, Zaba, Mlangeni, Elizabeth Gugu, Mlingo, Margaret, Mngqebisa, Bukiwe, Mngxekeza, Noluxolo, Mninzi, Anele, Mnqonywa, Nonzwakazi, Mogkoro, Mammekwa, Mogodiri, Thembisile Wilmah, Mohuba, Rebone Frengelina, Mokoena, Maseponki Cecilia, Mona, Noxolo, Montoya, Deidra, Monyethabeng, Willie, Moodley, Jayajothi, Moodley, Jeeva, Moodley, Kerushini, Moonsamy, Suri, Morar, Neetha Shagan, Morudu, Sophie Nomsa, Mpekula, Angela, Mphisa, Gerald Thsepo, Mpofu, Jayne, Mposula, Hlengiwe Theodora, Mqadi, Avril, Msiska, Emmie, Msumba, Lusungu, Mtambo, Nana, Mthalane, Emmanuel Sinothi, Mthembu, Thabisile Susan, Mthethi, Zanoxolo, Mthethwa, Magdeline Judith, Mthethwa, Ntokozo Zabathethwa, Mthimkhulu, Sicelo Samuel, Mtlokoa, Itsepheng, Mubiru, Michael Charles, Mudavanhu, Mary, Mufumisi, Anna Zvirevo, Mugagga, Agnes Mary, Muganga, Joanita, Mugava, Michelle, Mugenyi, Margaret, Mugocha, Caroline, Mugodhi, Faith, Mugwagwa, Norma, Muhlanga, Felix Godwin Sivhukile, Mukaka, Shorai, Mukasa, Dick, Mukasa, Restituta, Mukatipa, Mathews, Mukova, Shedina, Mulebeke, Sarah, Mulima, Joyce, Muller, Julio, Mulumba, Faith, Mupamombe, Tsitsi, Murandu, Constance, Murefu, Tarisai, Murewa, Fungai, Muringayi, Kudakwashe, Murombedzi, Caroline, Musara, Petina, Musisi, Jane Nsubuga, Musisi, Mary Maria, Musoke, Philippa, Mutebo, Joseph, Mutero, Prisca, Mutiti, Kudzai Santana, Mutizira, Shadreck, Mutsvunguma, Sharon, Muungani, Netsai, Muvunzi, Tariro, Muwawu, Rosemary, Mvelase, Samkelisiwe, Mvinjelwa, Priscilla Pamela, Mvuyane, Goodness Zoh, Mwafulirwa, Liness, Mwagomba, Pokiwe, Mwakhwawa, Thoko Gift, Mwebaza, Deborah, Mwenda, Wezi Longwe, Myeni, Nqobile, Mzolo, Angeline Doreen Nonhlanhla, Nabatanzi, Regina Bukenya, Nabisere, Joselyne, Nabukeera, Josephine, Nagawa, Christine Valerie, Naicker, Cherise, Naicker, Kumari, Naicker, Vimla, Naidoo, Ishana, Naidoo, Jason, Naidoo, Jayganthie, Naidoo, Kalendri, Naidoo, Logashvari, Naidoo, Renissa, Naidoo, Sandy, Naidu, Nalini, Nair, Gonasagrie Lulu, Nakabiito, Clemensia, Nakacwa, Susan, Nakakande, Joyce Gladys, Nakalega, Rita, Nakalema, Maria Gorreti, Nakibuka, Jesca, Nakyanzi, Teopista, Nakyeyune, Justine, Nalusiba, Stella, Namakula, Rhoda, Namalueso, Felix, Namayanja, Paula Mubiru, Nampala, Christine Tapuwa, Nampiira, Suzan Nkalubo, Namuddu, Agnes, Nandundu, Norah, Nansamba, Winnie, Nanyonga, Stella, Nanziri, Sophie Clare, Nassoma, Zainab Nakivumbi, Ncube, Duduzile Ethel, Ncube, Eva, Ncube, Sithabile, Ndadziyira, Pepukayi, Ndamase, Pamella Pumla, Nderecha, Walter Seth Taurayi, Ndhlovu-Forde, Zanele, Ndimande, Thembelihle Cynthia, Ndlovu, Bukekile, Ndlovu, Grecenia, Ndlovu, James, Ndlovu, Nontokozo Happiness, Ndlovu, Thakisile Nontokozo, Ndlovu, Zodwa, Ndovie, Margret, Nel, Annalene, Nemasango, Beauty, Neradilek, Blazej, Ngani, Susan, Ngcebethsha, Nokwanda Queeneth, Ngcobela, Lizbon, Ngcobo, Nolwazi, Ngcobo, Nompumelelo, Ngcobo, Sindisiwe Promise, Ngcukana, Nidleka, Ngo, Julie, Ngqabe, Nontshukumo, Ngqame, Siyabonga, Ngubane, Mduduzi Dawood, Ngure, Kenneth, Ngwenya, Nancy Nokuthula, Nhkoma, Mugowe, Nhlapho, Bongiwe Ntombizodwa, Nhleko, Sibusiso, Nkwanyana, Hlengiwe, Noble, Heather, Nobula, Lumka Lucia, Nolan, Monica, Nompondwana, Mluleki, Notshokovu, Busiwe, Ntanzi, Vukani Sandile, Nursaye, Nishi, Nutall, Jeremy Peter, Nyabadza, Omega, Nyaka, Evelesi, Nyakudya, Sandra, Nyakura, Envioletta Chiedza, Nyamadzawo, Shingayi, Nyamuzihwa, Tsitsi, Nyanzi, Zubayiri, Nyathi, Angel Tinny, Nyirenda, Fadire, Nyirenda, Makandwe, Nyirenda, Mary, Nzama, Sinqobile Charity, Nzuza, Lamec Sbongisomi, O'Byrne, Bhavesha, Okello, Fabian, Okumu, Eunice, Oluka, Emmanuel, Onen, Francis, Onyango, Carolyne Peris, Ostbye, Katherine, Padayachee, Kerusha, Palanee-Phillips, Thesla, Palichina, Victor, Pan, Zhenyu, Pappajohn, Colin, Paramanund, Levanya, Parikh, Urvi M., Patterson, Karen, Pearce, Nazmie, Peda, Melissa, Penrose, Kerri J., Phahlamohlaka, Bathandekile Molly, Phidane, Nokulunga Ruth, Pillay, Omisha, Premrajh, Anamika, Prosad, Nikita, Rabe, Lorna, Rajman, Alishka, Ramjee, Gita, Rampai, Keneoe Maphuti, Rampyapedi, Hlalifi Sylvia, Randhawa, April, Rasmeni, Sabelo, Rausch, Dianne, Reddy, Avanita, Reddy, Isayum, Reddy, Jerusha, Reddy, Krishnaveni, Rees, Vera Helen, Repetto, Andrea, Richards, Cheryl, Riddler, Sharon, Rini, Nobubele, Roeber, Brendon, Rohan, Lisa, Romer, Zachary, Rose, Matthew, Rosenberg, Zeda Fran, Rossi, Lisa, Ruch, Aviva, Rullo, Christine, Runeyi, Sinazo, Rupemba, Olivia, Rushwaya, Chenai, Russell, Marisa, Ruzive, Patience Sharai, Rwanzogyera, Godfrey, Saava, Margaret Nakato, Sagela, Tshepo Jimmy, Sakwa, Rebecca, Sayed, Fathima, Scheckter, Rachel, Schille, Jennifer, Scotch, Nokwayintombi, Scott, William, Scoville, Caitlin, Sebagala, Richard, Sebastian, Elaine, Sedze, Natasha Tina, Seedat, Nasreen Hoosen, Semakula, Joseph, Senn, Teri, Serugo, Francis, Seyama, Linly, Shabalala, Bhekanani Khumulani, Shangase, Charlotte Phumzile, Shanhinga, Pamela Caroline, Shaver, Jeremy, Shen, Hanjie, Shogole, Mogobalale Corlett, Shonhiwa, Rachel, Shozi, Claudia, Sibanda, Marvelous, Sibeko, Sylvia Sibongile, Sibisi, Ncamisile Teressa, Sibisi, Samuel Siphelele, Sibiya, Brighty Zweni, Sibiya, Happiness, Sichali, Dorothy, Sikosana, Phumzile Yvonne, Silva, Craig, Simelane, Ayanda Purity, Simon, Melissa, Sing, Triesha, Singh, Devika, Singh, Nishanta, Sithole, Hailey Virginia, Sitima, Edith, Siva, Samantha, Siyasiya, Alex, Sizane, Vuyane, Siziba, Bekezela, Slezinger, Edward, Smolinski, Daria, Snapinn, Katie, Sogoni, Olwethu, Soko, Dean, Solai, Leonard Nichiren, Somga, Mandiphumle, Song, Mei, Song, Xiaoling, Soobryan, Devarani, Soto-Torres, Lydia, Spence, Patrick Lawrence, Spooner, Elizabeth, Sseguya, Vincent, Ssentongo, Augustine, Ssenyonga, Mark, Sseremba, Lawrence Lollian, Stais, Michael, Steytler, John, Stockton, Sharon, Stofel, Julie, Stuurman, Tinyiko Reginah, Sukazi, Sizakele, Sukdao, Jasmin Lynn, Swarna, Kranthi, Szydlo, Daniel, Tagliaferri Rael, Christine, Taguta, Dorothy Rumbidzai, Taha, Taha, Tahuringana, Eunice, Tamale, Joshua, Tambama, Penelope, Taulo, Edna, Taulo, Frank, Tauya, Thelma Tonderai, Tegha, Gerald, Tembe, Sindisiwe Lucia, Tembo, Tchangani, Thatelo, Constance Lebo, Thobela, Pinky Mery, Thom, Annie, Thompson, Christine, Thompson, Monica, Thusi, Linda, Tock, Lauri, Tofile, Thandokazi, Torjesen, Kristine, Tranfaglia, Carol, Tseng, Jenny, Tshabalala, Themba, Tshongoyi, Nomvuselelo, Tsidya, Mercy, Tsikiwa, Wendy Rufaro, Tuswa-Haynes, NoCamagu, Tutshana, Bomkazi Onini, Twala, Andile Premrose, Udith, Ashvir Viren, Unten, Christine, van der Straten, Ariane, van Niekerk, Neliette, Varela, Amanda, Vatsha, Nangamso, Vijayendran, Gayathri, Vuma, Amukelani California, Wabwire, Deo Ogema, Walani, Madalo, Wanda, Bhekisisa, Wasberg, Lisa, White, Rhonda R., Windle, Kathleen Marie, Woeber, Kubashni, Wright, Danica, Wright, Tiffanee, Xaba, Thembalethu Nontokozo, Yambira, Makanaka Jean Savie, Yola, Ntando, Zaca, Sindisiwe Lydia, Zalwango, Aisha, Zemanek, Jullian, Zimba, Chifundo, Zinyengere, Tsitsi, Zinyongo, Margaret, Zondi, Thabile Goodness, Zou, Chun, Zuma, Jabulisile, Zungu, Nokuthula Princess, Zungu, Nompumelelo, Baeten, Jared M, Mgodi, Nyaradzo M, Mayo, Ashley J, Szydlo, Daniel W, Gati Mirembe, Brenda, Hunidzarira, Portia, Mansoor, Leila E, Nair, Gonasagrie, Parikh, Urvi M, Mellors, John W, Balán, Iván C, Hendrix, Craig W, Chirenje, Zvavahera M, Taha, Taha E, Rosenberg, Zeda, Soto-Torres, Lydia E, Hillier, Sharon L, and Brown, Elizabeth R

Published
2021
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3. Chloroquine as weekly chemoprophylaxis or intermittent treatment to prevent malaria in pregnancy in Malawi: a randomised controlled trial

Author

Divala, Titus H, Mungwira, Randy G, Mawindo, Patricia M, Nyirenda, Osward M, Kanjala, Maxwell, Ndaferankhande, Masiye, Tsirizani, Lufina E, Masonga, Rhoda, Muwalo, Francis, Boudová, Sarah, Potter, Gail E, Kennedy, Jessie, Goswami, Jaya, Wylie, Blair J, Muehlenbachs, Atis, Ndovie, Lughano, Mvula, Priscilla, Mbilizi, Yamikani, Tomoka, Tamiwe, and Laufer, Miriam K

Published
2018
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4. A latent trajectory analysis of young sexual and gender minorities' adherence to three rectal microbicide placebo formulations (MTN-035; a randomized crossover trial).

Author

Choi, Seul Ki, Bauermeister, José, Tingler, Ryan C., Johnson, Sherri, Macagna, Nicole, Ho, Ken, Hoesley, Craig, Liu, Albert, Kayange, Noel, Palanee-Phillips, Thesla, Chariyalertsak, Suwat, Gonzales, Pedro, Piper, Jeanna M., Mnemba, Abigail, Kamanga, Alinafe, Munthali, Annie, Gondwe, Daniel, Seyama, Linly, Mbilizi, Yamikani, and Chadza, Mary

Subjects
SEXUAL minorities, CROSSOVER trials, TEXT messages, SEXUALLY transmitted diseases, ANAL sex
Abstract

Background: Rectal microbicides (RM) are biomedical HIV prevention products that aim to prevent or reduce the transmission of HIV and other sexually transmitted infections (STIs). RM modalities may be beneficial for populations who have complex lifestyles, difficulties adhering to pre-exposure prophylaxis (PrEP) regimens, and/or have limited access to care. MTN-035 (DESIRE; Developing and Evaluating Short-Acting Innovations for Rectal Use), a randomized crossover trial, aimed to evaluate the safety and acceptability of, and adherence to, three placebo RM modalities (douche, insert, and suppository) prior to receptive anal intercourse. Methods: We conducted latent trajectory analysis to identify clusters of individuals who shared similar trajectories in acceptability and adherence for each product (douche, insert, and suppository) over time. We analyzed weekly short messaging service (SMS) use reports for each modality as reported by enrolled sexual and gender minority (SGM) participants. Results: Two trajectories for each product were identified: a "protocol compliant" trajectory (i.e., at least one product use occasion per week) and "high use" trajectory (i.e., more than three product use occasions per week). Participants with high use were more likely to lack access to PrEP and have higher intentions to utilize RM modalities compared to those who were protocol compliant. Conclusions: This study highlighted high adherence to RM modalities among SGM. As research into viable HIV prevention modalities continues to evolve, tailored intervention strategies are needed to support the uptake of and adherence to alternative prevention modalities that are behaviorally congruent with targeted users. Trial registration: NCT03671239 (14/09/2018). [ABSTRACT FROM AUTHOR]

Published
2023
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7. A Randomized Clinical Trial of Human Papillomavirus Test-and-Treat as Compared to Cytology-Based Screening for Prevention of Cervical Cancer Among Women With Human Immunodeficiency Virus: AIDS Clinical Trials Group Protocol A5282

Author

Wilkin, Timothy, primary, Chen, Huichao, additional, Sahasrabuddhe, Vikrant, additional, Matining, Roy, additional, Mngqibisa, Rosie, additional, Chinula, Lameck, additional, Mbilizi, Yamikani, additional, Magure, Tsitsi, additional, Omoz-Oarhe, Ayotunde E, additional, Rassool, Mohammed, additional, Riviere, Cynthia, additional, Bhosale, Rhamesh, additional, Godbole, Sheela, additional, Naranjo, Reena, additional, Coombs, Robert, additional, Michelow, Pamela, additional, Godfrey, Catherine, additional, and Firnhaber, Cynthia, additional

Published
2022
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8. Healthcare-related stigma among men who have sex with men and transgender women in sub-Saharan Africa participating in HIV Prevention Trials Network (HPTN) 075 study

Author

Mbeda, Calvin, Ogendo, Arthur, Lando, Richard, Schnabel, David, Gust, Deborah A., Guo, Xu, Akelo, Victor, Dominguez, Karen, Panchia, Ravindre, Mbilizi, Yamikani, Chen, Ying, Chege, Wairimu, and Sandfort, Theo

Subjects
Adult, Male, Malawi, medicine.medical_specialty, Health (social science), Sub saharan, Social Psychology, Attitude of Health Personnel, Health Personnel, Social Stigma, Human immunodeficiency virus (HIV), Stigma (botany), HIV Infections, medicine.disease_cause, Transgender Persons, Article, Health Services Accessibility, Transgender women, Men who have sex with men, Cohort Studies, Sexual and Gender Minorities, South Africa, 03 medical and health sciences, Health services, Discrimination, Psychological, 0302 clinical medicine, Health care, Retention in Care, Humans, Medicine, 030212 general & internal medicine, Homosexuality, Male, Aged, 030505 public health, business.industry, Public Health, Environmental and Occupational Health, virus diseases, Fear, Middle Aged, Patient Acceptance of Health Care, Kenya, Family medicine, Female, Prevention trials, 0305 other medical science, business
Abstract

The inability to access health services when needed is a critical barrier to HIV prevention, treatment, and care among men who have sex with men (MSM) and transgender women (TGW). Using data collected in HPTN 075, we explored factors associated with any any experienced healthcare-related stigma. HPTN 075 was a cohort study to assess the feasibility of recruiting and retaining MSM and TGW in clinical trials in sub-Saharan Africa. Of 401 MSM and TGW enrolled at four sites (Kisumu, Kenya; Blantyre, Malawi; Cape Town, Soweto, South Africa) 397 contributed to the analysis (79.9% cis-gender and 20.1% TGW). Of these, (45.3%; 180/397) reported one or more of healthcare-related stigma experiences. Most frequently reported experiences included fear to seek healthcare services (36.3%) and avoiding seeking such services because of discovery of MSM status (29.2%). Few men and TGW (2.5%) reported having been denied health services because of having sex with men. In multivariable analysis, more participants in Soweto [adjusted odds ratio (AOR) = 2.60] and fewer participants in Blantyre (AOR = 0.27) reported any healthcare-related stigma experiences, in comparison to participants in Kisumu. MSM and TGW that did not have a supportive gay community to rely on were more likely to report any healthcare-related stigma experiences (AOR = 1.46), whereas MSM and TGW who reported high social support and who never had engaged in transactional sex were less likely to report such experiences (AOR = 0.76 and AOR = 0.43, respectively). Our results suggest that encouraging support groups for MSM and TGW as well as training and sensitizing healthcare staff, and the general community, on MSM and TGW health issues and cultural competence may reduce stigma, improve access to healthcare, which could ultimately reduce HIV transmission.

Published
2020

9. Randomized Clinical Trial of Human Papillomavirus Test-and-Treat as Compared to Cytology-Based Screening for Prevention of Cervical Cancer Among Women With Human Immunodeficiency Virus: AIDS Clinical Trials Group Protocol A5282.

Author

Wilkin, Timothy, Chen, Huichao, Sahasrabuddhe, Vikrant, Matining, Roy, Mngqibisa, Rosie, Chinula, Lameck, Mbilizi, Yamikani, Magure, Tsitsi, Omoz-Oarhe, Ayotunde E, Rassool, Mohammed, Riviere, Cynthia, Bhosale, Rhamesh, Godbole, Sheela, Naranjo, Reena, Coombs, Robert, Michelow, Pamela, Godfrey, Catherine, and Firnhaber, Cynthia

Subjects
PAPILLOMAVIRUS disease diagnosis, HIV-positive persons, EVALUATION of medical care, BIOPSY, CYTODIAGNOSIS, COLD therapy, COLPOSCOPY, ELECTROSURGERY, WOMEN, EARLY detection of cancer, CERVICAL intraepithelial neoplasia, RANDOMIZED controlled trials, COMPARATIVE studies, CERVIX uteri tumors, STATISTICAL sampling
Abstract

Background Cytology-based cervical cancer screening followed by confirmation and treatment of biopsy-proven high-grade squamous intraepithelial lesions (bHSIL) is difficult to implement in resource-constrained settings. We hypothesized that high-risk human papillomavirus (hrHPV) testing followed by immediate cryotherapy of women with hrHPV (HPV screen-and-treat) may improve outcomes. Methods Randomized, open-label, phase 2, multinational clinical trial enrolling women with human immunodeficiency virus (HIV) age 18 or older with cervical hrHPV and having no cervical lesions or lesions appropriate for cryotherapy. Women were randomized to immediate cryotherapy (Arm A) or cytology-based screening (Arm B). For Arm A, cervical biopsies were obtained followed by cervical cryotherapy, and in Arm B, women with abnormal cytology underwent colposcopy followed by loop electroexcision procedure (LEEP) if bHSIL was detected. Women were followed through 30 months. The primary outcome was time to bHSIL detected from Month 6 through study completion. Results In total, 288 women (145 in Arm A, 143 in Arm B) were randomized: median age 35 years, 84% on antiretroviral therapy, median CD4 501 cells/mm3. In Arm A, 39 (27%) of women had bHSIL at entry, and in Arm B, 88 (62%) had abnormal cytology, 22 (15%) were diagnosed with bHSIL, 12 (8%) underwent LEEP. In follow-up, 30 (21%) and 31 (22%) developed bHSIL; time to bHSIL was similar between arms (P =.94). The prevalence of hrHPV at Month 6 was similar between arms (61% and 70%, P =.13). Conclusions HPV test-and-treat was not associated with improved bHSIL outcomes as compared to cytology-based screening. More effective treatment options are required to improve outcomes from screen-and-treat programs. Clinical Trials Registration NCT01315363. [ABSTRACT FROM AUTHOR]

Published
2022
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10. HIV incidence in a multinational cohort of men and transgender women who have sex with men in sub-Saharan Africa: Findings from HPTN 075

Author

Sandfort, Theodorus G. M., primary, Mbilizi, Yamikani, additional, Sanders, Eduard J., additional, Guo, Xu, additional, Cummings, Vanessa, additional, Hamilton, Erica L., additional, Akelo, Victor, additional, Panchia, Ravindre, additional, Dominguez, Karen, additional, Stirratt, Michael J., additional, Chege, Wairimu, additional, Lucas, Jonathan, additional, Gaydos, Charlotte A., additional, Chen, Ying Q., additional, and Eshleman, Susan H., additional

Published
2021
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11. Safety, uptake, and use of a dapivirine vaginal ring for HIV-1 prevention in African women (HOPE): an open-label, extension study

Author

Baeten, Jared M, primary, Palanee-Phillips, Thesla, additional, Mgodi, Nyaradzo M, additional, Mayo, Ashley J, additional, Szydlo, Daniel W, additional, Ramjee, Gita, additional, Gati Mirembe, Brenda, additional, Mhlanga, Felix, additional, Hunidzarira, Portia, additional, Mansoor, Leila E, additional, Siva, Samantha, additional, Govender, Vaneshree, additional, Makanani, Bonus, additional, Naidoo, Logashvari, additional, Singh, Nishanta, additional, Nair, Gonasagrie, additional, Chinula, Lameck, additional, Parikh, Urvi M, additional, Mellors, John W, additional, Balán, Iván C, additional, Ngure, Kenneth, additional, van der Straten, Ariane, additional, Scheckter, Rachel, additional, Garcia, Morgan, additional, Peda, Melissa, additional, Patterson, Karen, additional, Livant, Edward, additional, Bunge, Katherine, additional, Singh, Devika, additional, Jacobson, Cindy, additional, Jiao, Yuqing, additional, Hendrix, Craig W, additional, Chirenje, Zvavahera M, additional, Nakabiito, Clemensia, additional, Taha, Taha E, additional, Jones, Judith, additional, Torjesen, Kristine, additional, Nel, Annalene, additional, Rosenberg, Zeda, additional, Soto-Torres, Lydia E, additional, Hillier, Sharon L, additional, Brown, Elizabeth R, additional, Aanyu, Dorothy, additional, Abima, John, additional, Abullarade, Janne, additional, Agarwal, Priyanka, additional, Ahluwalia, Surabhi, additional, Akasiima, Simon Africa, additional, Akello, Carolyne Agwau, additional, Albert, Samuel, additional, Alphale, Motsamai, additional, Alphonse, Calins, additional, Apeduno, Lucy, additional, Aranda, Sara, additional, Aridor, Orly, additional, Arnolds, Shakeera, additional, Asiimwe, Prossy, additional, Atujuna, Millicent, additional, Atwebembere, Didas, additional, Baboolall, Lakshmi, additional, Badana, Kiran, additional, Baeten, Jared M., additional, Balamusani, David, additional, Balán, Iván C., additional, Banda, Gabriel, additional, Banda, Towera Whitney, additional, Baugh, Jennifer, additional, Baziira, James Amos, additional, Beamer, May, additional, Bebeza, Sivuyisiwe Asanda, additional, Bekker, Linda-Gail, additional, Bell, Ian, additional, Bemer, Meagan, additional, Berman, Richard, additional, Berthiaume, Jennifer, additional, Bezak, Linda, additional, Bhagwandin, Yashveer, additional, Bhayat, Hassen Anwar, additional, Bhengu, Nokulunga, additional, Bhengu, Sonto, additional, Bhoola, Aruna, additional, Biira, Florence Asiimwe, additional, Bittoni, Daniel, additional, Black, Roberta, additional, Blose, Nombuso Jacqueline, additional, Boks, Pearl, additional, Bolton, Stephen Gordon, additional, Botya, Phathiswa, additional, Brown, Amanda, additional, Brown, Elizabeth, additional, Brown, Helen, additional, Bruce, Robyn Helen, additional, Bukenya, Luke Erismus, additional, Bukirwa, Aidah, additional, Bunts, Lisa, additional, Buthelezi, Fezile, additional, Buthelezi, Mbongeleni William, additional, Buthelezi, Samkelisiwe Dumisile, additional, Byogero, Rose, additional, Byroo, Samiksha, additional, Byuma, Robert, additional, Carstens, Johanna Albertha, additional, Carter, Allison, additional, Cassim, Nazneen, additional, Cebekhulu, Busisiwe, additional, Cele, Bongekile, additional, Cele, Dolly Judith, additional, Cele, Phindile, additional, Cele, Simangele, additional, Cele, Sithabile, additional, Chadza, Mary, additional, Chakhtoura, Nahida, additional, Chapdu, Claire, additional, Chareka, Gift Tafadzwa, additional, Chasakara, Charles, additional, Chatani-Gada, Manju, additional, Chetty, Diana, additional, Chidanyika, Mary, additional, Chifambi, Tafadzwa Tariro Lisa, additional, Chihota, Emelder, additional, Chikono, Sungano, additional, Chikonyora, Anesu, additional, Chikukwa, Brett Dzidzai, additional, Chin, Craig, additional, Chindevu, Mary, additional, Chinyanda, Tendai Blessing, additional, Chirenda, Thandiwe Hilda, additional, Chirenje, Zvavahera Mike, additional, Chirisa, Chiedza, additional, Chisale, Patience, additional, Chishanga, Angela, additional, Chitambo, Tobias, additional, Chitema, Fred, additional, Chithila, Flora, additional, Chitowa, Tinei Helen, additional, Chitsinde, Catherine, additional, Chitsulo, Gladys, additional, Chitukuta, Miria, additional, Chiveso, Spiwe, additional, Chome, Nelecy, additional, Chonco, Phumelele Fortune, additional, Christopher, Emily, additional, Chunderduri, Kerusha, additional, Cibi, Vutomi, additional, Cleland, Naana, additional, Coba, Thobeka, additional, Cobbing, Mandy Rae, additional, Collins, Clare, additional, Comer, Kim, additional, Cozzi, Shameen, additional, Crida, Danielle, additional, Dadabhai, Sufia, additional, Daki, Thembakazi, additional, Danster, Nwabisa, additional, Dassaye, Reshmi, additional, David, Renita, additional, Davis, Jontraye M., additional, Dawood, Sumaya, additional, Deb, Pallabi, additional, Degnam, Leslie, additional, Derrick, Tiffany Sharron, additional, Devlin, Bríd Teresa, additional, Dezzutti, Charlene, additional, Dhlakama, Patricia Mae, additional, Dias, Lorna, additional, Dimairo, Jean Chivoniso, additional, Dinnie, Elaine, additional, Dlabanta, Avile, additional, Dladla, Msizi, additional, Dladla, Thandeka Immaculate, additional, Dlungele, Andile Princess, additional, Dolezal, Curtis, additional, Donaty, Kristine, additional, Dott, Clare, additional, Dubbs, Jenna, additional, Dubula-Majola, Vuyiseka, additional, Dukwe, Pamella, additional, Duma, Cebo Ivan, additional, Duma, Portia Ignatia Makhosazana, additional, Duma, Promise, additional, Duncan, Vimbai Kudzanai, additional, Duran, Luis, additional, Dyabeni, Lindelwa, additional, Edwards, Andrew, additional, Etikala, Radhika, additional, Etima, Juliane, additional, Fairlie, Lee, additional, Fischer, Henry, additional, Fitzpatrick, Jacqueline, additional, Fleurs, Llewellyn, additional, Fowler, Mary Glenn, additional, Freeman, Lester, additional, Gaffoor, Zakir, additional, Gama, Lizzy, additional, Garg, Anita, additional, Gatsi, Vanesa Margret, additional, Gcwensa, Clifford, additional, Gebashe, Emmanuel Lwandile, additional, Geduld, Samantha, additional, Gelant, Jennipher, additional, Germuga, Donna, additional, Ggita, Joseph, additional, Giguere, Rebecca, additional, Godo, Lucy, additional, Goetz, B. Jay, additional, Gogo, Litha, additional, Goliati, Esther, additional, Gondwe, Daniel Kondwani, additional, Gordon, Kelley C., additional, Goreraza, Rodney, additional, Gounden, Jayandree, additional, Govender, Dhevium, additional, Govender, Justin Sivalingum, additional, Govender, Nerusha, additional, Govender, Subramonien, additional, Gqwara, Nonkululeko Nosipho, additional, Gravelle, Anisa (Tracy), additional, Guga, Phindile, additional, Guma, Victor, additional, Gumede, Delisile Zilungile, additional, Gumede, Sibusiso, additional, Gumede, Thembelihle, additional, Gumede, Thobeka Winifred, additional, Gundani, Orgrah, additional, Gunnam, Ravi, additional, Gupta, Rahul, additional, Gwande, Mirriam, additional, Gxako, Xolani, additional, Hall, Kim, additional, Hall, Wayne, additional, Hargrave, Perry, additional, Harkoo, Ishana, additional, Harrell, Tanya, additional, Heaps, Amy L., additional, Hendricks, Simone Lara, additional, Hendrix, Craig W., additional, Hlabisa, Bongeka, additional, Hlabisa, Lungile Bongeka, additional, Hlahla, Kudzai, additional, Hlela, Thulebona Martin, additional, Hobongwana, Thandiwe, additional, Horn, Eva, additional, Howard, Ridley, additional, Huang, Haixiao, additional, Hunidzairia, Portia, additional, Hurbans, Nivriti, additional, Husnik, Marla, additional, Hwehwe, Tendai Doreen, additional, Imamdin, Rabia, additional, Ismail, Amina, additional, Jacobs, Ebrahiema, additional, Jacques, Ashleigh Catherine, additional, Jamabya, Jane, additional, James, Grace, additional, Janse van Rensburg, Karla, additional, Jaya, Ziningi Nobuhle, additional, Jeenarain, Nitesha, additional, Jennings, Lauren, additional, Jiang, Haoping, additional, Jiang, Ning, additional, Jijana, Nwabisa Laurianne, additional, Jokoniya, Godfrey, additional, Kabasonga, Mildred, additional, Kabenge, Daniel Kizza, additional, Kabwigu, Samuel, additional, Kachale, Evans, additional, Kachenjera, Lonely, additional, Kachingamire, Fiona, additional, Kachipapa, Emma, additional, Kadiwa, Mary, additional, Kadyamusuma, McLoddy, additional, Kafufu, Bosco, additional, Kagwa, Mary Mukasa, additional, Kajura-Manyindo, Clare, additional, Kakayi, Brenda Catherine, additional, Kaliwo, Victoria, additional, Kalonji, Dishiki Jenny, additional, Kamanga, Nyasha Elizabeth, additional, Kamira, Betty, additional, Kampangire, Zerif, additional, Kamwana, Getrude, additional, Kamya, Justine, additional, Kapa, La-Donna, additional, Karugaba, Patrick, additional, Kasambara, Khumbo, additional, Kassim, Priya, additional, Kassim, Sheetal, additional, Katana, Milly, additional, Katongole, Francis, additional, Katongole, Sulaiman, additional, Katsis, Alexis, additional, Katumbi, Chaplain, additional, Katz, Ariana W.K., additional, Kawanje, Edmore, additional, Kawuma, Caroline Nassozi, additional, Kayongo, Sowedi, additional, Kekana, Emily, additional, Kemigisha, Doreen, additional, Khanyile, Siphosihle, additional, Khanyisile, Nombuso Happiness, additional, Khaya, Babalwa, additional, Khiya, Noluthando, additional, Khoza, Norah Ntombikayise, additional, Khumalo, Thembisile, additional, Khwela, Christina, additional, Khwela, Zamo, additional, Kibiribiri, Edith, additional, Kibirige, Ismael, additional, Kiiza, Beatrice, additional, Kikonyogo, Florence Sempa, additional, Kin, Melissa, additional, Kirkwood, Catherine, additional, Kistnasami, Girisha, additional, Kiweewa, Flavia Matovu, additional, Kiweewa, Max, additional, Konatham, Deepika, additional, Kubheka, Lungile, additional, Kufakunesu, Terrence, additional, Kumwenda, Phaleda, additional, Kumwenda, Wiza Wisdom Isaac, additional, Kush, Maura, additional, Kutner, Bryan A., additional, Kwatsha, Ntomboxolo, additional, Kwedza, Rosper, additional, Kyomukama, Erinah, additional, Lands, Debra, additional, Langa, Phumelele Nokuthula, additional, Lebeta, Kalkidan, additional, Lentz, Cody, additional, Leremi, Brendley Tebogo, additional, Leszczewski, Michelle, additional, Levy, Lisa, additional, Livant, Ted, additional, Lukas, Irene, additional, Mabanga, Lungile Pearl, additional, Mabaso, Nomusa, additional, Machisa, Vimbainashe, additional, Maddox, Toni M., additional, Madlala, Bernadette, additional, Magobiane, Nocwaka, additional, Magolela, Melda, additional, Maguramhinga, Fungai, additional, Magwaza, Phumzile Desiree, additional, Maharaj, Keshnee, additional, Mahed, Ferial, additional, Mahlase, Tankiso Vuyiswa, additional, Maila, Moshukutjoane Lebogang, additional, Makala, Yvonne, additional, Makamure, Patrick, additional, Makgoka, Kgabo Phineas, additional, Makhamba, Pamela, additional, Makhanya, Nompumelelo, additional, Makondo, Rulani, additional, Makoni, Rujeko, additional, Makooka, Henry, additional, Makunganya, Jennie, additional, Makwenda, Sibongile, additional, Malan, Gakiema, additional, Malemia, Agnes, additional, Malherbe, Mariette, additional, Malunga, Faith, additional, Mamba Nhassengo, Temantfulini, additional, Mampa, Mogau, additional, Mamvura, Tendai Karen, additional, Manengamambo, Elmah, additional, Mangove, Loreen Zandile, additional, Mangxilana, Nomvuyo Thelma, additional, Manjera, Tsungai Patience, additional, Mans, Winifred Elizabeth, additional, Mansoor, Leila, additional, Maoko, Memory, additional, Mapfunde, Annie, additional, Maphumulo, Nonhlanhla Yvonne, additional, Martinson, Francis E.A., additional, Maruwo, Abel, additional, Marx, Emmerentia Yvonne, additional, Marzinke, Mark A., additional, Masango, Moira, additional, Mashego, Mmathabo Nnana, additional, Mashinini, Gwendoline Thotele Refilwe, additional, Masuko, Shingirayi Irene, additional, Matambanadzo, Kudzai Viviana, additional, Mathebula, Florence Tintswalo, additional, Mathipa, Matheus, additional, Matsa, Jacob Munyaradzi, additional, Matta, Eleanor Agnes, additional, Matubu, Allen Taguma, additional, Mavundla, Ayanda Comfort, additional, Mavundla, Sandile, additional, Mawindo, Billy, additional, Mayani, Josiah, additional, Mayanja, Emmanuel, additional, Mayekiso, Nombongo, additional, Mayisela, Nonkululeko Precious, additional, Mayo, Ashley J., additional, Mbabali, Mary Speciosa, additional, Mbanjwa, Nonhlakanipho Masibonge Gciniwe, additional, Mbatha, Constance Seanokeng, additional, Mbatha, Nomcedo Janice, additional, Mbewe, Dorica, additional, Mbichila, Tinkhani, additional, Mbilizi, Yamikani Rose, additional, Mbokazi, Sithokoza, additional, Mbwerera, Mwandifitsa, additional, Mchunu, Zethu, additional, McKinstry, Laura, additional, Mdlongwa, Bongiwe, additional, Mellors, John W., additional, Meyiwa, Sihle Perfect, additional, Mgodi, Nyaradzo Mavis, additional, Mhizha, Erasmus Samuel, additional, Mhlanga, Nomsa Sibongile, additional, Mirembe, Brenda Gail, additional, Mirembe, Dorothy, additional, Mkandawire, Fumbani, additional, Mkhabela, Ntombizethu Hazel, additional, Mkhize, Baningi, additional, Mkhize, Princess Hlengiwe, additional, Mkhize, Zaba, additional, Mlangeni, Elizabeth Gugu, additional, Mlingo, Margaret, additional, Mngqebisa, Bukiwe, additional, Mngxekeza, Noluxolo, additional, Mninzi, Anele, additional, Mnqonywa, Nonzwakazi, additional, Mogkoro, Mammekwa, additional, Mogodiri, Thembisile Wilmah, additional, Mohuba, Rebone Frengelina, additional, Mokoena, Maseponki Cecilia, additional, Mona, Noxolo, additional, Montoya, Deidra, additional, Monyethabeng, Willie, additional, Moodley, Jayajothi, additional, Moodley, Jeeva, additional, Moodley, Kerushini, additional, Moonsamy, Suri, additional, Morar, Neetha Shagan, additional, Morudu, Sophie Nomsa, additional, Mpekula, Angela, additional, Mphisa, Gerald Thsepo, additional, Mpofu, Jayne, additional, Mposula, Hlengiwe Theodora, additional, Mqadi, Avril, additional, Msiska, Emmie, additional, Msumba, Lusungu, additional, Mtambo, Nana, additional, Mthalane, Emmanuel Sinothi, additional, Mthembu, Thabisile Susan, additional, Mthethi, Zanoxolo, additional, Mthethwa, Magdeline Judith, additional, Mthethwa, Ntokozo Zabathethwa, additional, Mthimkhulu, Sicelo Samuel, additional, Mtlokoa, Itsepheng, additional, Mubiru, Michael Charles, additional, Mudavanhu, Mary, additional, Mufumisi, Anna Zvirevo, additional, Mugagga, Agnes Mary, additional, Muganga, Joanita, additional, Mugava, Michelle, additional, Mugenyi, Margaret, additional, Mugocha, Caroline, additional, Mugodhi, Faith, additional, Mugwagwa, Norma, additional, Muhlanga, Felix Godwin Sivhukile, additional, Mukaka, Shorai, additional, Mukasa, Dick, additional, Mukasa, Restituta, additional, Mukatipa, Mathews, additional, Mukova, Shedina, additional, Mulebeke, Sarah, additional, Mulima, Joyce, additional, Muller, Julio, additional, Mulumba, Faith, additional, Mupamombe, Tsitsi, additional, Murandu, Constance, additional, Murefu, Tarisai, additional, Murewa, Fungai, additional, Muringayi, Kudakwashe, additional, Murombedzi, Caroline, additional, Musara, Petina, additional, Musisi, Jane Nsubuga, additional, Musisi, Mary Maria, additional, Musoke, Philippa, additional, Mutebo, Joseph, additional, Mutero, Prisca, additional, Mutiti, Kudzai Santana, additional, Mutizira, Shadreck, additional, Mutsvunguma, Sharon, additional, Muungani, Netsai, additional, Muvunzi, Tariro, additional, Muwawu, Rosemary, additional, Mvelase, Samkelisiwe, additional, Mvinjelwa, Priscilla Pamela, additional, Mvuyane, Goodness Zoh, additional, Mwafulirwa, Liness, additional, Mwagomba, Pokiwe, additional, Mwakhwawa, Thoko Gift, additional, Mwebaza, Deborah, additional, Mwenda, Wezi Longwe, additional, Myeni, Nqobile, additional, Mzolo, Angeline Doreen Nonhlanhla, additional, Nabatanzi, Regina Bukenya, additional, Nabisere, Joselyne, additional, Nabukeera, Josephine, additional, Nagawa, Christine Valerie, additional, Naicker, Cherise, additional, Naicker, Kumari, additional, Naicker, Vimla, additional, Naidoo, Ishana, additional, Naidoo, Jason, additional, Naidoo, Jayganthie, additional, Naidoo, Kalendri, additional, Naidoo, Renissa, additional, Naidoo, Sandy, additional, Naidu, Nalini, additional, Nair, Gonasagrie Lulu, additional, Nakacwa, Susan, additional, Nakakande, Joyce Gladys, additional, Nakalega, Rita, additional, Nakalema, Maria Gorreti, additional, Nakibuka, Jesca, additional, Nakyanzi, Teopista, additional, Nakyeyune, Justine, additional, Nalusiba, Stella, additional, Namakula, Rhoda, additional, Namalueso, Felix, additional, Namayanja, Paula Mubiru, additional, Nampala, Christine Tapuwa, additional, Nampiira, Suzan Nkalubo, additional, Namuddu, Agnes, additional, Nandundu, Norah, additional, Nansamba, Winnie, additional, Nanyonga, Stella, additional, Nanziri, Sophie Clare, additional, Nassoma, Zainab Nakivumbi, additional, Ncube, Duduzile Ethel, additional, Ncube, Eva, additional, Ncube, Sithabile, additional, Ndadziyira, Pepukayi, additional, Ndamase, Pamella Pumla, additional, Nderecha, Walter Seth Taurayi, additional, Ndhlovu-Forde, Zanele, additional, Ndimande, Thembelihle Cynthia, additional, Ndlovu, Bukekile, additional, Ndlovu, Grecenia, additional, Ndlovu, James, additional, Ndlovu, Nontokozo Happiness, additional, Ndlovu, Thakisile Nontokozo, additional, Ndlovu, Zodwa, additional, Ndovie, Margret, additional, Nemasango, Beauty, additional, Neradilek, Blazej, additional, Ngani, Susan, additional, Ngcebethsha, Nokwanda Queeneth, additional, Ngcobela, Lizbon, additional, Ngcobo, Nolwazi, additional, Ngcobo, Nompumelelo, additional, Ngcobo, Sindisiwe Promise, additional, Ngcukana, Nidleka, additional, Ngo, Julie, additional, Ngqabe, Nontshukumo, additional, Ngqame, Siyabonga, additional, Ngubane, Mduduzi Dawood, additional, Ngwenya, Nancy Nokuthula, additional, Nhkoma, Mugowe, additional, Nhlapho, Bongiwe Ntombizodwa, additional, Nhleko, Sibusiso, additional, Nkwanyana, Hlengiwe, additional, Noble, Heather, additional, Nobula, Lumka Lucia, additional, Nolan, Monica, additional, Nompondwana, Mluleki, additional, Notshokovu, Busiwe, additional, Ntanzi, Vukani Sandile, additional, Nursaye, Nishi, additional, Nutall, Jeremy Peter, additional, Nyabadza, Omega, additional, Nyaka, Evelesi, additional, Nyakudya, Sandra, additional, Nyakura, Envioletta Chiedza, additional, Nyamadzawo, Shingayi, additional, Nyamuzihwa, Tsitsi, additional, Nyanzi, Zubayiri, additional, Nyathi, Angel Tinny, additional, Nyirenda, Fadire, additional, Nyirenda, Makandwe, additional, Nyirenda, Mary, additional, Nzama, Sinqobile Charity, additional, Nzuza, Lamec Sbongisomi, additional, O'Byrne, Bhavesha, additional, Okello, Fabian, additional, Okumu, Eunice, additional, Oluka, Emmanuel, additional, Onen, Francis, additional, Onyango, Carolyne Peris, additional, Ostbye, Katherine, additional, Padayachee, Kerusha, additional, Palichina, Victor, additional, Pan, Zhenyu, additional, Pappajohn, Colin, additional, Paramanund, Levanya, additional, Parikh, Urvi M., additional, Pearce, Nazmie, additional, Penrose, Kerri J., additional, Phahlamohlaka, Bathandekile Molly, additional, Phidane, Nokulunga Ruth, additional, Pillay, Omisha, additional, Premrajh, Anamika, additional, Prosad, Nikita, additional, Rabe, Lorna, additional, Rajman, Alishka, additional, Rampai, Keneoe Maphuti, additional, Rampyapedi, Hlalifi Sylvia, additional, Randhawa, April, additional, Rasmeni, Sabelo, additional, Rausch, Dianne, additional, Reddy, Avanita, additional, Reddy, Isayum, additional, Reddy, Jerusha, additional, Reddy, Krishnaveni, additional, Rees, Vera Helen, additional, Repetto, Andrea, additional, Richards, Cheryl, additional, Riddler, Sharon, additional, Rini, Nobubele, additional, Roeber, Brendon, additional, Rohan, Lisa, additional, Romer, Zachary, additional, Rose, Matthew, additional, Rosenberg, Zeda Fran, additional, Rossi, Lisa, additional, Ruch, Aviva, additional, Rullo, Christine, additional, Runeyi, Sinazo, additional, Rupemba, Olivia, additional, Rushwaya, Chenai, additional, Russell, Marisa, additional, Ruzive, Patience Sharai, additional, Rwanzogyera, Godfrey, additional, Saava, Margaret Nakato, additional, Sagela, Tshepo Jimmy, additional, Sakwa, Rebecca, additional, Sayed, Fathima, additional, Schille, Jennifer, additional, Scotch, Nokwayintombi, additional, Scott, William, additional, Scoville, Caitlin, additional, Sebagala, Richard, additional, Sebastian, Elaine, additional, Sedze, Natasha Tina, additional, Seedat, Nasreen Hoosen, additional, Semakula, Joseph, additional, Senn, Teri, additional, Serugo, Francis, additional, Seyama, Linly, additional, Shabalala, Bhekanani Khumulani, additional, Shangase, Charlotte Phumzile, additional, Shanhinga, Pamela Caroline, additional, Shaver, Jeremy, additional, Shen, Hanjie, additional, Shogole, Mogobalale Corlett, additional, Shonhiwa, Rachel, additional, Shozi, Claudia, additional, Sibanda, Marvelous, additional, Sibeko, Sylvia Sibongile, additional, Sibisi, Ncamisile Teressa, additional, Sibisi, Samuel Siphelele, additional, Sibiya, Brighty Zweni, additional, Sibiya, Happiness, additional, Sichali, Dorothy, additional, Sikosana, Phumzile Yvonne, additional, 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additional, Swarna, Kranthi, additional, Szydlo, Daniel, additional, Tagliaferri Rael, Christine, additional, Taguta, Dorothy Rumbidzai, additional, Taha, Taha, additional, Tahuringana, Eunice, additional, Tamale, Joshua, additional, Tambama, Penelope, additional, Taulo, Edna, additional, Taulo, Frank, additional, Tauya, Thelma Tonderai, additional, Tegha, Gerald, additional, Tembe, Sindisiwe Lucia, additional, Tembo, Tchangani, additional, Thatelo, Constance Lebo, additional, Thobela, Pinky Mery, additional, Thom, Annie, additional, Thompson, Christine, additional, Thompson, Monica, additional, Thusi, Linda, additional, Tock, Lauri, additional, Tofile, Thandokazi, additional, Tranfaglia, Carol, additional, Tseng, Jenny, additional, Tshabalala, Themba, additional, Tshongoyi, Nomvuselelo, additional, Tsidya, Mercy, additional, Tsikiwa, Wendy Rufaro, additional, Tuswa-Haynes, NoCamagu, additional, Tutshana, Bomkazi Onini, additional, Twala, Andile Premrose, additional, Udith, Ashvir Viren, additional, Unten, Christine, additional, van Niekerk, Neliette, additional, Varela, Amanda, additional, Vatsha, Nangamso, additional, Vijayendran, Gayathri, additional, Vuma, Amukelani California, additional, Wabwire, Deo Ogema, additional, Walani, Madalo, additional, Wanda, Bhekisisa, additional, Wasberg, Lisa, additional, White, Rhonda R., additional, Windle, Kathleen Marie, additional, Woeber, Kubashni, additional, Wright, Danica, additional, Wright, Tiffanee, additional, Xaba, Thembalethu Nontokozo, additional, Yambira, Makanaka Jean Savie, additional, Yola, Ntando, additional, Zaca, Sindisiwe Lydia, additional, Zalwango, Aisha, additional, Zemanek, Jullian, additional, Zimba, Chifundo, additional, Zinyengere, Tsitsi, additional, Zinyongo, Margaret, additional, Zondi, Thabile Goodness, additional, Zou, Chun, additional, Zuma, Jabulisile, additional, Zungu, Nokuthula Princess, additional, and Zungu, Nompumelelo, additional

Published
2021
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12. Pregnancy and Infant Outcomes Among Women Using the Dapivirine Vaginal Ring in Early Pregnancy.

Author

Makanani B, Balkus JE, Jiao Y, Noguchi LM, Palanee-Phillips T, Mbilizi Y, Moodley J, Kintu K, Reddy K, Kabwigu S, Jeenariain N, Harkoo I, Mgodi N, Piper J, Rees H, Scheckter R, Beigi R, and Baeten JM

Subjects
Adolescent, Adult, Africa South of the Sahara, Child Development, Double-Blind Method, Female, Humans, Infant, Newborn, Middle Aged, Placebos administration & dosage, Pregnancy, Young Adult, Anti-HIV Agents administration & dosage, Contraceptive Devices, Female, HIV Infections prevention & control, Pregnancy Outcome, Pyrimidines administration & dosage
Abstract

Background: Monthly use of the dapivirine vaginal ring has been shown to be safe and effective for HIV-1 prevention in nonpregnant reproductive-aged women. The impact of dapivirine on pregnancy outcomes and infant is not known. We compared pregnancy incidence and outcomes by study arm among HIV-1-uninfected women who became pregnant while participating in MTN-020/ASPIRE., Methods: ASPIRE was a randomized, double-blind, placebo-controlled phase III safety and effectiveness study of the dapivirine ring for HIV-1 prevention. Sexually active women aged 18-45 years from Malawi, South Africa, Uganda, and Zimbabwe were enrolled. Urine pregnancy tests were performed monthly, and, if positive, study product was withheld during pregnancy and breastfeeding. Pregnancy-related outcomes included the following: pregnancy incidence, pregnancy outcomes (live birth, preterm birth, pregnancy loss, and congenital anomalies), and infant growth., Results: Of 2629 women enrolled in ASPIRE, 169 became pregnant during follow-up, resulting in 179 incident pregnancies and 181 pregnancy outcomes. No difference in pregnancy incidence by study arm was observed (hazard ratio = 0.93; 95% confidence interval: 0.68 to 1.26). The distribution of pregnancy outcomes was similar by study arm, and no difference was noted in the frequency or pattern of congenital anomalies or infant growth parameters by study arm., Conclusions: Dapivirine use in the periconception period does not seem to be associated with adverse effects on pregnancy or infant outcomes. Our findings provide support for additional safety studies of the dapivirine ring throughout pregnancy.

Published
2018
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13. Performance of a Validated Risk Score to Predict HIV-1 Acquisition Among African Women Participating in a Trial of the Dapivirine Vaginal Ring.

Author

Balkus JE, Brown ER, Palanee-Phillips T, Matovu Kiweewa F, Mgodi N, Naidoo L, Mbilizi Y, Jeenarain N, Gaffoor Z, Siva S, Nair G, Pather A, and Baeten JM

Subjects
Adult, Africa, Eastern, Africa, Southern, Anti-HIV Agents pharmacology, Female, Follow-Up Studies, HIV Infections transmission, Humans, Patient Compliance, Validation Studies as Topic, Young Adult, Anti-HIV Agents administration & dosage, Contraceptive Devices, Female, HIV Infections prevention & control, HIV-1 drug effects, Pre-Exposure Prophylaxis methods, Pyrimidines administration & dosage, Pyrimidines pharmacology
Published
2018
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