40 results on '"Mbarki S"'
Search Results
2. 3D Objects Indexing Using Chebyshev Polynomial
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Oulahrir, Y., primary, Elmounchid, F., additional, Hellam, S., additional, Sadiq, A., additional, and Mbarki, S., additional
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- 2019
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3. Poster session Wednesday 11 December all day display: 11/12/2013, 09: 30–16: 00Location: Poster area
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Zaroui, A, Mourali, MS, Rezine, Z, Mbarki, S, Jemaa, M, Aloui, H, Mechmeche, R, and Farhati, A
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- 2013
4. Special issue in honour of Prof. Reto J. Strasser - JIP-test as a tool to identify salinity tolerance in sweet sorghum genotypes
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RASTOGI, A., primary, KOVAR, M., additional, HE, X., additional, ZIVCAK, M., additional, KATARIA, S., additional, KALAJI, H.M., additional, SKALICKY, M., additional, IBRAHIMOVA, U.F., additional, HUSSAIN, S., additional, MBARKI, S., additional, and BRESTIC, M., additional
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- 2020
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5. Protective effect of essential oil from Citrus limon against aspirin-induced toxicity in rats
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Bouzenna, H, primary, Samout, N, additional, Dhibi, S, additional, Mbarki, S, additional, Akermi, S, additional, Khdhiri, A, additional, Elfeki, A, additional, and Hfaiedh, N, additional
- Published
- 2018
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6. Gamified Stress Management Calendar for Higher Education Students
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Berehil, M., primary, Arrhioui, K., additional, and Mbarki, S., additional
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- 2017
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7. JIP-test as a tool to identify salinity tolerance in sweet sorghum genotypes.
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RASTOGI, A., KOVAR, M., HE, X., ZIVCAK, M., KATARIA, S., KALAJI, H. M., SKALICKY, M., IBRAHIMOVA, U. F., HUSSAIN, S., MBARKI, S., and BRESTIC, M.
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SORGO ,OSMOTIC pressure ,SALINITY ,GENOTYPES ,SORGHUM ,CHLOROPHYLL - Abstract
The effect of salinity on primary photochemical reactions (using JIP-test) in six sweet sorghum genotypes was tested. An increase in salt concentrations induced significantly the accumulation of proline and caused a decline in leaf osmotic potential. Except for 100 mM NaCl concentration, salinity significantly decreased chlorophyll content and photosynthetic efficiency of plants. Increasing salinity led to a higher accumulation of QB-nonreducing PSII reaction centers. K-step in OJIP fluorescence transient was observed for the most sensitive genotypes under the high NaCl concentration. The studied sorghum genotypes responded differently to salinity stress. Thus, the study helps understand the plant tolerance mechanisms of different sweet sorghum genotypes to increasing salinity stress. The study also confirmed that the use of JIP-test is suitable for the identification of sorghum genotypes according to their growth under salinity stress. [ABSTRACT FROM AUTHOR]
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- 2020
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8. Protective effect of essential oil from Citrus limon against aspirin-induced toxicity in rats.
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Bouzenna, H, Samout, N, Dhibi, S, Mbarki, S, Akermi, S, Khdhiri, A, Elfeki, A, and Hfaiedh, N
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ESSENTIAL oils ,LEMON ,LABORATORY rats ,ANTIOXIDANTS ,HYDROGEN peroxide ,FLAVONOIDS ,FLAVONOLS ,ASPIRIN - Abstract
The present study is planned to examine the antioxidant activity (AA) and the protective effect of the essential oil of Citrus limon (EOC) against aspirin-induced histopathological changes in the brain, lung, and intestine of female rats. For this purpose, 28 albino rats were classified to control group (group C), aspirin group (group A), EOC group (group EOC), and pretreatment with EOC and treated with aspirin group (group EOC + A). The antioxidant activities of EOC were evaluated by three different assays including reducing power, β-carotene, and scavenging of hydrogen peroxide (H
2 O2 ). Our results found that EOC represents, respectively (0.064 ± 0.013 and 0.027 ± 00 mg Quer E/100 µL), of flavonoid and flavonol. Then, it exhibited a potential activity of reducing power (at 300 mg/mL, which was found to be 0.82 ± 0.07), β-carotene-linoleic acid (AA% = 69.28 ± 3.5%), and scavenging of H2 O2 (IC50 = 0.23 ± 0.008 mg/mL). In vivo, aspirin given to rats at the dose of 600 mg/kg body weight induced histomorphological damage in brain, lung, and intestine. However, our data found that the pretreatment with EOC offered a significant protection against the injury induced by aspirin. It can be concluded that the protective effect of EOC can be due to its antioxidant activities. [ABSTRACT FROM AUTHOR]- Published
- 2019
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9. Accumulation capacity of ions in cabbage (Brassica oleracea L.) supplied with sea water
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Gu, M.F., primary, Li, N., additional, Shao, T.Y., additional, Long, X.H., additional, Brestič, M., additional, Shao, H.B., additional, Li, J.B., additional, and Mbarki, S., additional
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- 2016
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10. Gamified Stress Management Calendar for Higher Education Students.
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Berehil, M., Arrhioui, K., and Mbarki, S.
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- 2017
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11. An efficient method for Objects indexing in three dimensions
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Hellam, S., primary, Oulahrir, Y., additional, El Mounchid, F., additional, Sadiq, A., additional, and Mbarki, S., additional
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- 2015
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12. Model-Driven Transformation for GWT with Approach by Modeling: from UML Model to MVP Web Applications
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Esbai, Redouane, primary, Erramdani, M., additional, and Mbarki, S., additional
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- 2014
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13. Femoral parosteal osteosarcoma 18 years after its discovery: A case report
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Ben Brahim, E., Sebai, M.A., Mbarki, S., Tangour, M., Bouzaïdi, K., Ben Romdhane, K., Tebib, M., and Chatti, S.
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- 2009
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14. Ostéosarcome parostéal du fémur après 18 ans d’évolution : à propos d’un cas
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Ben Brahim, E., Sebai, M.A., Mbarki, S., Tangour, M., Bouzaïdi, K., Ben Romdhane, K., Tebib, M., and Chatti, S.
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- 2009
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15. Generating Graphical User Interfaces Based on Model Driven Engineering.
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Roubi, S., Erramdani, M., and Mbarki, S.
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GRAPHICAL user interfaces ,SOFTWARE architecture ,SOFTWARE engineering ,COMPUTER software development ,PROGRAM transformation - Abstract
In this article we present our approach developed concerning the generation of usable User Interfaces (UI), then we show its results, starting as a basis with UML models. Indeed, we based the approach on the Model Driven Engineering and the development of specific meta models for UI from the perspective of a UML model-based design on one hand and a set of transformations on the other hand. Indeed, we defined a new meta model that is neither a use case nor an activity diagram, but our way to describe the UI in terms of the user's interactions. Thus we used the good practices of Designs Patterns when developing the meta models. The approach includes first creating a platform independent model (PIM) and transforming this PIM into platform specific model (PSM) thought transformation rules. The PIM is created first based on the UML use case and activities diagrams to extract the main functionalities offered by the system to be developed. Then we established the PSM meta model, being the target model of our transformation engine, taking into account the design patterns composite and MVC. With this methodology, the UI can easily be analyzed, designed, and generated to increase system development. [ABSTRACT FROM AUTHOR]
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- 2015
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16. An Experiment on the Design of Radial Basis Function Neural Networks for Software Cost Estimation.
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Dri, A., Abran, A., and Mbarki, S.
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- 2006
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17. Model-Driven Transformations: from Analysis to MVC 2 Web Model.
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Mbarki, S. and Erramdani, M.
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COMPUTER software development ,SOFTWARE engineering ,XML (Extensible Markup Language) ,UNIFIED modeling language - Abstract
Web applications have the complexity of designing, developing, maintaining, and managing. These systems have increased significantly as well. To cope with this complexity, several frameworks (supporting the MVC 2 pattern) have been elaborated Facing this diversity and incessant improvement of Web technology, we are in need of developing a tool which is able to produce the code from analysis-level UML models. In this paper, we apply MDA approach for generating code from requirements to MVC 2 Web implementation. That is why we have developed two metamodels handling UML class diagrams and MVC 2 Web applications, then we have to set up two transformations. The first one is a PIM to PIM transformation allowing the refinement of the analysis-level class diagram. The second one is a PIM to PSM transformation for MVC 2 Web applications. [ABSTRACT FROM AUTHOR]
- Published
- 2009
18. Effects of MgCl2 supplementation on blood parameters and kidney injury of rats exposed to CCl4
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Mbarki Sakhria, Dhibi Sabah, Bouzenna Hafsia, Elfeki Abdelfettah, and Hfaiedh Najla
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ccl4 ,magnesium ,kidney ,hematology ,oxidative stress ,Biology (General) ,QH301-705.5 - Abstract
The purpose of this study was to evaluate the beneficial effects of magnesium (Mg) supplementation upon carbon tetrachloride (CCl4) toxicity. Our study was carried out on 24 Wistar male rats divided into 4 batches. During a 6 week period, one group served as a control, two groups received Mg (after 4 weeks one of these groups was then treated with CCl4), and a final group was treated with CCl4 only. Under our experimental conditions, CCl4 poisoning resulted in oxidative stress indicated by a significant increase in lipid peroxidation level in renal tissues. The blood levels of creatinine and urea increased while the blood level of uric acid and proteins decreased. CCl4 also induced an increase in superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity in kidneys, in the number of red blood cells (RBC), and in hemoglobin content (Hb) and mean cell hemoglobin concentration (MCHC). However, white blood cell count (WBC), platelet count (Pl) and catalase activity (CAT) all decreased significantly. Treatment with Mg was found to alleviate most of CCl4-induced damage by decreasing lipid peroxidation and by correcting changed hematological parameters, and catalase, glutathione peroxidase and superoxide-dismutase activities. The results provide strong evidence that Mg supplementation is beneficial in protecting the kidneys from CCl4 toxicity.
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- 2016
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19. Myocardial infarction during pregnancy complicated by acute adrenal insufficiency,Infarctus du myocarde en cours de grossesse compliqué d'insuffisance surrénalienne aiguë
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Mghaieth, F., AYARI JIHENE, Mbarki, S., Mizouni, H., Sfar, E., Mourali, M. S., Mnif, E., Chelli, H., and Mechmèche, R.
20. Contrast-induced nephropathy after cardiac catheterization: A prospective study of 180 patients,Néphropathie induite par les produits de contraste iodés après cathétérisme cardiaque: Une étude prospective de 180 patients
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Mghaieth, F., AYARI JIHENE, Rejeb, R. B., Mbarki, S., Farhati, A., Larbi, N., Boussaada, R., Mourali, M. S., and Mechmèche, R.
21. An Experiment on the Design of Radial Basis Function Neural Networks for Software Cost Estimation
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Idri, A., primary, Abran, A., additional, and Mbarki, S., additional
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22. Validating and understanding software cost estimation models based on neural networks
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Idri, A., primary, Mbarki, S., additional, and Abran, A., additional
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23. Validating and understanding software cost estimation models based on neural networks.
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Idri, A., Mbarki, S., and Abran, A.
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- 2004
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24. Acute myocardial infarction in a patient with hypofibrinogenemia: a case report
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Mghaieth Fathia, Mizouni Habiba, Mbarki Sihem, Ayari Jihen, Trabelsi Ramy, Moussa Nidhal, Mourali Mohamed, Mnif Emna, and Mechmeche Rachid
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Medicine - Abstract
Abstract Introduction Congenital fibrinogen deficiency is a rare coagulation disorder usually responsible for hemorrhagic diathesis. However, it can be associated with thrombosis and there have been limited reports of arterial thrombotic complications in these patients. Case presentation A 42-year-old Tunisian man with congenital hypofibrinogenemia and no cardiovascular risk factors presented with new onset prolonged angina pectoris. An electrocardiogram showed features of inferior acute myocardial infarction. His troponin levels had reached 17 ng/L. Laboratory findings confirmed hypofibrinogenemia and ruled out thrombophilia. Echocardiography was not useful in providing diagnostic elements but did show preserved left ventricular function. Coronary angiography was not performed and our patient did not receive any anticoagulant treatment due to the major risk of bleeding. Magnetic resonance imaging confirmed myocardial necrosis. Our patient was managed with aspirin, a beta-blocker, an angiotensin-converting enzyme inhibitor and statin medication. The treatment was well tolerated and no ischemic recurrence was detected. Conclusion Although coronary thrombosis is a rare event in patients with fibrinogen deficiency, this condition is of major interest in view of the difficulties observed in managing these patients.
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- 2011
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25. Poster session Wednesday 11 December all day display: 11/12/2013, 09:30-16:00 * Location: Poster area
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Bertrand, PB, Grieten, L, Smeets, C, Verbrugge, FH, Mullens, W, Vrolix, M, Rivero-Ayerza, M, Verhaert, D, Vandervoort, P, Tong, L, Ramalli, A, Tortoli, P, Dhoge, J, Bajraktari, G, Lindqvist, P, Henein, MY, Obremska, M, Boratynska, MB, Kurcz, JK, Zysko, DZ, Baran, TB, Klinger, MK, Darahim, K, Mueller, H, Carballo, D, Popova, N, Vallee, J-P, Floria, M, Chistol, R, Tinica, G, Grecu, M, Rodriguez Serrano, M, Osa-Saez, A, Rueda-Soriano, J, Buendia-Fuentes, F, Domingo-Valero, D, Igual-Munoz, B, Alonso-Fernandez, P, Quesada-Carmona, A, Miro-Palau, V, Palencia-Perez, M, Bech-Hanssen, O, Polte, CL, Lagerstrand, K, Janulewicz, M, Gao, S, Erdogan, E, Akkaya, M, Bacaksiz, A, Tasal, A, Sonmez, O, Turfan, M, Kul, S, Vatankulu, MA, Uyarel, H, Goktekin, O, Mincu, RI, Magda, LS, Mihaila, S, Florescu, M, Mihalcea, D, Enescu, OE, Chiru, A, Popescu, B, Tiu, C, Vinereanu, D, 112/2011, Research grant, Broch, K, Kunszt, G, Massey, R, De Marchi, SF, Aakhus, S, Gullestad, L, Urheim, S, Yuan, L, Feng, JL, Jin, XY, Bombardini, T, Casartelli, M, Simon, D, Gaspari, MG, Procaccio, F, Hasselberg, NE, Haugaa, KH, Brunet, A, Kongsgaard, E, Donal, E, Edvardsen, T, Sahin, TAYLAN, Yurdakul, S, Cengiz, BETUL, Bozkurt, AYSEN, Aytekin, SAIDE, Cesana, F, Spano, F, Santambrogio, G, Alloni, M, Vallerio, P, Salvetti, M, Carerj, S, Gaibazzi, N, Rigo, F, Moreo, A, Group, APRES Collaborative, Wdowiak-Okrojek, K, Michalski, B, Kasprzak, JD, Shim, A, Lipiec, P, Generati, G, Pellegrino, M, Bandera, F, Donghi, V, Alfonzetti, E, Guazzi, M, Marcun, R, Stankovic, I, Farkas, J, Vlahovic-Stipac, A, Putnikovic, B, Kadivec, S, Kosnik, M, Neskovic, AN, Lainscak, M, Iliuta, L, Szymanski, P, Lipczynska, M, Klisiewicz, A, Sobieszczanska-Malek, M, Zielinski, T, Hoffman, P, Gjerdalen, G F, Hisdal, J, Solberg, EE, Andersen, TE, Radunovic, Z, Steine, K, Svanadze, A, Poteshkina, N, Krylova, N, Mogutova, P, Shim, A, Kasprzak, JD, Szymczyk, E, Wdowiak-Okrojek, K, Michalski, B, Stefanczyk, L, Lipiec, P, Benedek, T, Matei, C, Jako, B, Suciu, ZS, Benedek, I, Yaroshchuk, N A, Kochmasheva, V V, Dityatev, V P, Kerbikov, O B, Przewlocka-Kosmala, M, Orda, A, Karolko, B, Mysiak, A, Kosmala, W, Rechcinski, T, Wierzbowska-Drabik, K, Lipiec, P, Chmiela, M, Kasprzak, JD, Aziz, A, Hooper, J, Rayasamudra, S, Uppal, H, Asghar, O, Potluri, R, Zaroui, A, Mourali, MS, Rezine, Z, Mbarki, S, Jemaa, M, Aloui, H, Mechmeche, R, Farhati, A, Gripari, P, Maffessanti, F, Tamborini, G, Muratori, M, Fusini, L, Vignati, C, Bartorelli, AL, Alamanni, F, Agostoni, PG, Pepi, M, Ruiz Ortiz, M, Mesa, D, Delgado, M, Seoane, T, Carrasco, F, Martin, M, Mazuelos, F, Suarez De Lezo Herreros De Tejada, J, Romero, M, Suarez De Lezo, J, Brili, S, Stamatopoulos, I, Misailidou, M, Chrisochoou, C, Christoforatou, E, Stefanadis, C, Ruiz Ortiz, M, Mesa, D, Delgado, M, Martin, M, Seoane, T, Carrasco, F, Ojeda, S, Segura, J, Pan, M, Suarez De Lezo, J, Cammalleri, V, Ussia, GP, Muscoli, S, Marchei, M, Sergi, D, Mazzotta, E, Romeo, F, Igual Munoz, B, Bel Minguez, ABM, Perez Guillen, MPG, Maceira Gonzalez, AMG, Monmeneu Menadas, JVMM, Hernandez Acuna, CHA, Estornell Erill, JEE, Lopez Lereu, PLL, Francisco Jose Valera Martinez, FJVM, Montero Argudo, AMA, Sunbul, M, Akhundova, A, Sari, I, Erdogan, O, Mutlu, B, Cacicedo, A, Velasco Del Castillo, S, Anton Ladislao, A, Aguirre Larracoechea, U, Rodriguez Sanchez, I, Subinas Elorriaga, A, Oria Gonzalez, G, Onaindia Gandarias, J, Laraudogoitia Zaldumbide, E, Lekuona Goya, I, Ding, W, Zhao, Y, Lindqvist, P, Nilson, J, Winter, R, Holmgren, A, Ruck, A, Henein, MY, Attenhofer Jost, C H, Soyka, R, Oxenius, A, Kretschmar, O, Valsangiacomo Buechel, ER, Greutmann, M, Weber, R, Keramida, K, Kouris, N, Kostopoulos, V, Karidas, V, Damaskos, D, Makavos, G, Paraskevopoulos, K, Olympios, CD, Eskesen, K, Olsen, NT, Fritz-Hansen, T, Sogaard, P, Cameli, M, Lisi, M, Righini, FM, Curci, V, Massoni, A, Natali, B, Maccherini, M, Chiavarelli, M, Massetti, M, Mondillo, S, Mabrouk Salem Omar, A, Ahmed Abdel-Rahman, M, Khorshid, H, Rifaie, O, Santoro, C, Santoro, A, Ippolito, R, De Palma, D, De Stefano, F, Muscariiello, R, Galderisi, M, Squeri, A, Censi, S, Baldelli, M, Grattoni, C, Cremonesi, A, Bosi, S, Saura Espin, D, Gonzalez Canovas, C, Gonzalez Carrillo, J, Oliva Sandoval, MJ, Caballero Jimenez, L, Espinosa Garcia, MD, Garcia Navarro, M, Valdes Chavarri, M, De La Morena Valenzuela, G, Ryu, SK, Shin, DG, Son, JW, Choi, JH, Goh, CW, Choi, JW, Park, JY, Hong, GR, Sklyanna, O, Yuan, L, Yuan, L, Planinc, I, Bagadur, G, Ljubas, J, Baricevic, Z, Skoric, B, Velagic, V, Bijnens, B, Milicic, D, Cikes, M, Gospodinova, M, Chamova, T, Guergueltcheva, V, Ivanova, R, Tournev, I, Denchev, S, Ancona, R, Comenale Pinto, S, Caso, P, Arenga, F, Coppola, MG, Calabro, R, Neametalla, H, Boitard, S, Hamdi, H, Planat-Benard, V, Casteilla, L, Li, Z, Hagege, AA, Mericskay, M, Menasche, P, Agbulut, O, Merlo, M, Stolfo, D, Anzini, M, Negri, F, Pinamonti, B, Barbati, G, Di Lenarda, A, Sinagra, G, Stolfo, D, Merlo, M, Pinamonti, B, Gigli, M, Poli, S, Porto, A, Di Nora, C, Barbati, G, Di Lenarda, A, Sinagra, G, Coppola, C, Piscopo, G, Cipresso, C, Rea, D, Maurea, C, Esposito, E, Arra, C, Maurea, N, Nemes, A, Kalapos, A, Domsik, P, Forster, T, Voilliot, D, Huttin, O, Vaugrenard, T, Schwartz, J, Sellal, J-M, Aliot, E, Juilliere, Y, Selton-Suty, C, Sanchez Millan, P J, Cabeza Lainez, P, Castillo Ortiz, J, Chueca Gonzalez, EM, Gheorghe, L, Fernandez Garcia, P, Herruzo Rojas, MS, Del Pozo Contreras, R, Fernandez Garcia, M, Vazquez Garcia, R, Rosca, M, Popescu, BA, Botezatu, D, Calin, A, Beladan, CC, Gurzun, M, Enache, R, Ginghina, C, Farouk, H, Al-Maimoony, T, Alhadad, A, El Serafi, M, Abdel Ghany, M, Poorzand, H, Mirfeizi, SZ, Javanbakht, A, center, Preventive Cardiovascular care research, center, Lupus Research, sciences, Mashhad university of medical, Tellatin, S, Famoso, G, Dassie, F, Martini, C, Osto, E, Maffei, P, Iliceto, S, Tona, F, Radunovic, Z, Steine, KS, Jedrzejewska, I, Braksator, W, Krol, W, Swiatowiec, A, Sawicki, J, Kostarska-Srokosz, E, Dluzniewski, M, Maceira Gonzalez, A M, Cosin-Sales, J, Diago, JL, Aguilar, J, Ruvira, J, Monmeneu, J, Igual, B, Lopez-Lereu, MP, Estornell, J, Olszanecka, A, Dragan, A, Kawecka-Jaszcz, K, Czarnecka, D, Scholz, F, Gaudron, PD, Hu, K, Liu, D, Florescu, C, Herrmann, S, Bijnens, B, Ertl, G, Stoerk, S, Weidemann, F, Krestjyaninov, M, Razin, VA, Gimaev, RH, Bogdanovic, Z, Burazor, I, Deljanin Ilic, M, Peluso, D, Muraru, D, Cucchini, U, Mihaila, S, Casablanca, S, Pigatto, E, Cozzi, F, Punzi, L, Badano, LP, Iliceto, S, Zhdanova, E, Rameev, VV, Safarova, AF, Moisseyev, SV, Kobalava, ZD, Magnino, C, Omede, P, Avenatti, E, Presutti, D, Losano, I, Moretti, C, Bucca, C, Gaita, F, Veglio, F, Milan, A, Bellsham-Revell, H, Bell, AJ, Miller, OI, Simpson, JM, Hwang, YM, Kim, GH, Jung, MH, Woo, GH, Medicine, Department of Internal, Hospital, St.Vincents, Korea, The Catholic University of, Suwon, Division of Cardiology, Repu, Driessen, MMP, Leiner, T, Schoof, PH, Breur, JMPJ, Sieswerda, GT, Meijboom, FJ, Bellsham-Revell, H, Hayes, N, Anderson, D, Austin, BC, Razavi, R, Greil, GF, Simpson, JM, Bell, AJ, Zhao, XX, Xu, XD, Qin, YW, Szmigielski, C A, Styczynski, G, Sobczynska, M, Placha, G, Kuch-Wocial, A, Ikonomidis, I, Voumbourakis, A, Triantafyllidi, H, Pavlidis, G, Varoudi, M, Papadakis, I, Trivilou, P, Paraskevaidis, I, Anastasiou-Nana, M, Lekakis, I, Kong, WILL, Yip, JAMES, Ling, LH, Milan, A, Tosello, F, Leone, D, Bruno, G, Losano, I, Avenatti, E, Sabia, L, Veglio, F, Zaborska, B, Baran, J, Pilichowska-Paszkiet, E, Sikora-Frac, M, Michalowska, I, Kulakowski, P, Budaj, A, Mega, S, Bono, MC, De Francesco, V, Castiglione, I, Ranocchi, F, Casacalenda, A, Goffredo, C, Patti, G, Di Sciascio, G, Musumeci, F, Kennedy, M, Waterhouse, DF, Sheahan, R, Foley, DF, Mcadam, BF, Ancona, R, Comenale Pinto, S, Caso, P, Arenga, F, Coppola, MG, Calabro, R, Remme, E W, Smedsrud, M K, Hasselberg, N E, Smiseth, O A, Edvardsen, T, Halmai, L, Nemes, A, Kardos, A, Neubauer, S, Degiovanni, A, Baduena, L, Dellera, G, Occhetta, E, Marino, P, Hotchi, J, Yamada, H, Nishio, S, Bando, M, Hayashi, S, Hirata, Y, Amano, R, Soeki, T, Wakatsuki, T, Sata, M, Lamia, B, Molano, LC, Viacroze, C, Cuvelier, A, Muir, JF, Lipczynska, M, Piotr Szymanski, PS, Anna Klisiewicz, AK, Lukasz Mazurkiewicz, LM, Piotr Hoffman, PH, Van T Sant, J, Wijers, SC, Ter Horst, IAH, Leenders, GE, Cramer, MJ, Doevendans, PA, Meine, M, Hatam, N, Goetzenich, A, Aljalloud, A, Mischke, K, Hoffmann, R, Autschbach, R, Sikora-Frac, M, Zaborska, B, Maciejewski, P, Bednarz, B, Budaj, A, Evangelista, A, Torromeo, C, Pandian, NG, Nardinocchi, P, Varano, V, Schiariti, M, Teresi, L, Puddu, PE, Storve, S, Dalen, H, Snare, SR, Haugen, BO, Torp, H, Fehri, W, Mahfoudhi, H, Mezni, F, Annabi, MS, Taamallah, K, Dahmani, R, Haggui, A, Hajlaoui, N, Lahidheb, D, Haouala, H, Colombo, A, Carminati, MC, Maffessanti, F, Gripari, P, Pepi, M, Lang, RM, Caiani, EG, Walker, JR, Abadi, S, Agmon, Y, Carasso, S, Aronson, D, Mutlak, D, Lessick, J, Saxena, A, Ramakrishnan, S, Juneja, R, Ljubas, J, Reskovic Luksic, V, Matasic, R, Pezo Nikolic, B, Lovric, D, Separovic Hanzevacki, J, Quattrone, A, Zito, C, Alongi, G, Vizzari, G, Bitto, A, De Caridi, G, Greco, M, Tripodi, R, Pizzino, G, Carerj, S, Ibrahimi, P, Jashari, F, Johansson, E, Gronlund, C, Bajraktari, G, Wester, P, Henein, MY, Kosmala, W, Marwick, TH, Souza, J R M, Zacharias, L G T, Geloneze, B, Pareja, J C, Chaim, A, Nadruz, W JR, Coelho, O R, Apostolovic, S, Stanojevic, D, Jankovic-Tomasevic, R, Salinger-Martinovic, S, Djordjevic-Radojkovic, D, Pavlovic, M, Tahirovic, E, Musial-Bright, L, Lainscak, M, Duengen, HD, group, CIBIS ELD study, Filipiak, D, Kasprzak, JD, and Lipiec, P
- Abstract
Purpose: With the advent of percutaneous transcatheter device closures in congenital heart defects and the emergence of percutaneous left atrial appendage closure, there is an increasingly important role for echocardiographic guidance and control of device position and function. Disc occluder devices frequently present as an unexplained ‘figure-of-8’ on echocardiography. The aim of this study was to clarify this ‘figure-of-8’ display and to relate its morphology to transducer position and device type. Methods: A mathematical model was developed to resemble disc occluder geometry and to allow a numerical simulation of the echocardiographic appearance. In addition, we developed an in vitro set-up for echocardiographic analysis of various disc occluders and various transducer positions. Results: In the mathematical model of an epitrochoid curve (closely resembling disc occluder geometry) a ‘figure-of-8’ display is obtained when emphasizing points with tangent vector perpendicular to the direction of ultrasound waves. Decreasing imaging depth results in a more asymmetric ‘figure-of-8’, with small upper part and wide lower part. Clinical and in vitro data are in close agreement with these results (Figure 1). Furthermore a ‘figure-of-8’ display is only obtained in a coronal imaging position, and is similar for different commercially available disc occluder types. Conclusions: The ‘figure-of-8’ display in the ultrasound image of a disc occluder is an imaging artifact due to the specific ‘epitrochoidal’ geometry of a deployed device and its interaction with ultrasound waves. The morphology of the ‘figure-of-8’ depends on transducer position, i.e. imaging depth, and is similar for different device types.
Figure 1 Impact of imaging depth - Published
- 2013
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26. Molecular cloning and characterization of heat-responsive LcOPR1, a gene encoding oxophytodienoic acid reductase in lentil.
- Author
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Abu-Romman S, Mbarki S, Al-Momany B, Skalicky M, Brestic M, Alalawy AI, Pandey S, Alasmari A, M Alzuaibr F, Sakran M, Ercisli S, El-Sharnouby M, and El Sabagh A
- Subjects
- Oxidoreductases genetics, Oxidoreductases metabolism, Amino Acid Sequence, Plant Proteins genetics, Plant Proteins metabolism, Hot Temperature, Genes, Plant, Heat-Shock Response genetics, Oxylipins metabolism, Oxidoreductases Acting on CH-CH Group Donors, Lens Plant genetics, Lens Plant enzymology, Cloning, Molecular methods, Gene Expression Regulation, Plant genetics, Phylogeny
- Abstract
Improving crop plants using biotechnological implications is a promising and modern approach compared to traditional methods. High-temperature exposure to the reproductive stage induces flower abortion and declines grain filling performance, leading to smaller grain production and low yield in lentil and other legumes. Thus, cloning effective candidate genes and their implication in temperature stress tolerance in lentil (Lens culinaris Medik.) using biotechnological tools is highly demandable. The 12-oxophytodienoic acid reductases (OPRs) are flavin mononucleotide-dependent oxidoreductases with vital roles in plants. They are members of the old yellow enzyme (OYE) family. These enzymes are involved in the octadecanoid pathway, which contributes to jasmonic acid biosynthesis and is essential in plant stress responses. Lentil is one of the vital legume crops affected by the temperature fluctuations caused by global warming. Therefore, in this study, the LcOPR1 gene was successfully cloned and isolated from lentils using RT-PCR to evaluate its functional responses in lentil under heat stress. The bioinformatics analysis revealed that the full-length cDNA of LcOPR1 was 1303 bp, containing an 1134 bp open reading frames (ORFs), encoding 377 amino acids with a predicted molecular weight of 41.63 and a theoretical isoelectric point of 5.61. Bioinformatics analyses revealed that the deduced LcOPR1 possesses considerable homology with other plant 12-oxophytodienoic acid reductases (OPRs). Phylogenetic tree analysis showed that LcOPR1 has an evolutionary relationship with other OPRs in different plant species of subgroup I, containing enzymes that are not required for jasmonic acid biosynthesis. The expression analysis of LcOPR1 indicated that this gene is upregulated in response to the heat-stress condition and during recovery in lentil. This study finding might be helpful to plant breeders and biotechnologists in LcOPR1 engineering and/or plant breeding programs in revealing the biological functions of LcOPR1 in lentils and the possibility of enhancing heat stress tolerance by overexpressing LcOPR1 in lentil and other legume plants under high temperature.
- Published
- 2024
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27. Epidemiology of diabetes mellitus in Tunisia. HSHS 2 study (Hammam Sousse Sahloul Heart Study).
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Mbarki S, Ben Abdelaziz A, Ben Hassine D, Melki S, Ben Rejeb N, Omezzine A, Bouslama A, and Ben Abdelaziz A
- Subjects
- Adult, Aged, Body Mass Index, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Prevalence, Risk Factors, Tunisia epidemiology, Diabetes Mellitus epidemiology, Overweight epidemiology
- Abstract
Background: National epidemiological studies on diabetes mellitus are rare, ancient and often carried out schools or clinics settings., Objectives: To determine the prevalence of diabetes mellitus and identify its risk factors in the adult population of the city of Hammam Sousse (Tunisia) during the year 2009., Methods: This study is a part of analysis of the HSHS database (Hammam Sousse Sahloul Heart Study), a «community-based» cross-sectional study on cardiovascular risk factors including diabetes mellitus, with a two-stage proportional probability cluster random sample. All subjects aged 20 years and more underwent a lifestyle interview, clinical examination with anthropometric measurements, and blood sampling. The diagnosis of diabetes mellitus was defined by a fasting blood glucose level ≥7 mmol/l. Overweight was defined by a Body Mass Index (BMI) ≥ 25 kg/m². A multivariate logistic regression analysis was conducted to determine independent risk factors associated with diabetes mellitus., Results: The population was composed of 481 males (M) and 960 females (F), a sex ratio of 0.5 with mean ages respectively of 49.6±16.35 years and 46.6±16.18 years. The prevalence of diabetes mellitus adjusted by age and sex was 12.1% (95%CI[11.7-12.5]); M: 12.7% (95%CI[12.1-13.3]), F: 11.5% (95%CI[10.9-12.1]). The prevalence rate of patients newly detected with diabetes mellitus was 1.9% (95%CI[1.7-2.1]): M: 1.8% (95%CI[1.6-2.0]), F: 2.1% (95%CI[1.8-2.4]). The multivariate study revealed five independent factors significantly associated with diabetes mellitus. In addition to non-modifiable factors (male gender, age ≥40 years old, low schooling level and family history of diabetes), diabetes mellitus was 2 (95%CI[1.3-3.2]) times more prevalent in overweight cases., Conclusion: In deep trouble of this epidemiological situation of diabetes mellitus, it is urgent to launch a universal intervention strategy based on the promotion of a healthy lifestyle motivating regular physical activity and a low-calorie diet.
- Published
- 2022
28. Fractionation of Heavy Metals in Multi-Contaminated Soil Treated with Biochar Using the Sequential Extraction Procedure.
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Awad M, Liu Z, Skalicky M, Dessoky ES, Brestic M, Mbarki S, Rastogi A, and El Sabagh A
- Subjects
- Cadmium chemistry, Cadmium isolation & purification, Cadmium metabolism, Charcoal isolation & purification, Copper chemistry, Copper isolation & purification, Copper metabolism, Environmental Pollution, Ferric Compounds chemistry, Ferric Compounds metabolism, Hydrogen-Ion Concentration, Lamiales chemistry, Lead chemistry, Lead isolation & purification, Lead metabolism, Manganese Compounds chemistry, Manganese Compounds metabolism, Metals, Heavy isolation & purification, Metals, Heavy metabolism, Microscopy, Electron, Scanning, Organic Chemicals chemistry, Organic Chemicals metabolism, Oxides chemistry, Oxides metabolism, Principal Component Analysis, Sasa chemistry, Spectrometry, X-Ray Emission, Zinc chemistry, Zinc isolation & purification, Zinc metabolism, Charcoal chemistry, Chemical Fractionation methods, Metals, Heavy chemistry, Soil chemistry
- Abstract
Heavy metals (HMs) toxicity represents a global problem depending on the soil environment's geochemical forms. Biochar addition safely reduces HMs mobile forms, thus, reducing their toxicity to plants. While several studies have shown that biochar could significantly stabilize HMs in contaminated soils, the study of the relationship of soil properties to potential mechanisms still needs further clarification; hence the importance of assessing a naturally contaminated soil amended, in this case with Paulownia biochar (PB) and Bamboo biochar (BB) to fractionate Pb, Cd, Zn, and Cu using short sequential fractionation plans. The relationship of soil pH and organic matter and its effect on the redistribution of these metals were estimated. The results indicated that the acid-soluble metals decreased while the fraction bound to organic matter increased compared to untreated pots. The increase in the organic matter metal-bound was mostly at the expense of the decrease in the acid extractable and Fe/Mn bound ones. The highest application of PB increased the organically bound fraction of Pb, Cd, Zn, and Cu (62, 61, 34, and 61%, respectively), while the BB increased them (61, 49, 42, and 22%, respectively) over the control. Meanwhile, Fe/Mn oxides bound represents the large portion associated with zinc and copper. Concerning soil organic matter (SOM) and soil pH, as potential tools to reduce the risk of the target metals, a significant positive correlation was observed with acid-soluble extractable metal, while a negative correlation was obtained with organic matter-bound metal. The principal component analysis (PCA) shows that the total variance represents 89.7% for the TCPL-extractable and HMs forms and their relation to pH and SOM, which confirms the positive effect of the pH and SOM under PB and BB treatments on reducing the risk of the studied metals. The mobility and bioavailability of these metals and their geochemical forms widely varied according to pH, soil organic matter, biochar types, and application rates. As an environmentally friendly and economical material, biochar emphasizes its importance as a tool that makes the soil more suitable for safe cultivation in the short term and its long-term sustainability. This study proves that it reduces the mobility of HMs, their environmental risks and contributes to food safety. It also confirms that performing more controlled experiments, such as a pot, is a disciplined and effective way to assess the suitability of different types of biochar as soil modifications to restore HMs contaminated soil via controlling the mobilization of these minerals.
- Published
- 2021
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29. Exogenous γ-aminobutyric acid (GABA)-induced signaling events and field performance associated with mitigation of drought stress in Phaseolus vulgaris L.
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Abd El-Gawad HG, Mukherjee S, Farag R, Abd Elbar OH, Hikal M, Abou El-Yazied A, Abd Elhady SA, Helal N, ElKelish A, El Nahhas N, Azab E, Ismail IA, Mbarki S, and Ibrahim MFM
- Subjects
- Antioxidants metabolism, Ascorbate Peroxidases metabolism, Cell Membrane drug effects, Lipid Peroxidation drug effects, Lipid Peroxidation radiation effects, Malondialdehyde metabolism, Osmosis, Signal Transduction drug effects, Superoxide Dismutase metabolism, Droughts, Phaseolus metabolism, gamma-Aminobutyric Acid pharmacology
- Abstract
Not much information is available to substantiate the possible role of γ -aminobutyric acid (GABA) signaling in mitigating water-deficit stress in snap bean ( Phaseolus vulgaris L.) plants under semiarid conditions. Present work aims to investigate the role of exogenous GABA (foliar application; 0.5, 1 and 2 mM) in amelioration of drought stress and improvement of field performance on snap bean plants raised under two drip irrigation regimes (100% and 70% of water requirements). Water stress led to significant reduction in plant growth, leaf relative water content (RWC), cell membrane stability index (CMSI), nutrient uptake (N, P, K, Ca, Fe and Zn), pod yield and its content from protein and total soluble solids (TSS). Meanwhile, lipid peroxidation (malondialdehyde content- MDA), osmolyte content (free amino acids- FAA, proline, soluble sugars) antioxidative defense (activity of superoxide dismutase- SOD, catalase- CAT, peroxidase- POX and ascorbate peroxidase- APX) and the pod fiber content exhibited significantly increase due to water stress. Exogenous GABA application (especially at 2 mM) revealed partial normalization of the effects of drought stress in snap bean plants. GABA-induced mitigation of drought stress was manifested by improvement in growth, water status, membrane integrity, osmotic adjustment, antioxidant defense and nutrient acquisition. Furthermore, GABA application during water stress in snap bean plants resulted in improvement of field performance being manifested by increased pod yield and its quality attributes. To sum up, exogenous GABA appears to function as an effective priming molecule to alleviate drought stress in snap bean plants under semiarid conditions.
- Published
- 2021
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30. Comparing Salt Tolerance at Seedling and Germination Stages in Local Populations of Medicago ciliaris L. to Medicago intertexta L. and Medicago scutellata L.
- Author
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Mbarki S, Skalicky M, Vachova P, Hajihashemi S, Jouini L, Zivcak M, Tlustos P, Brestic M, Hejnak V, and Khelil AZ
- Abstract
Salt stress is one of the most serious environmental stressors that affect productivity of salt-sensitive crops. Medicago ciliaris is an annual legume whose adaptation to agroclimatic conditions has not been well described. This study focused on the salinity tolerance of M. ciliaris genotypes compared to M. intertexta and M. scutellata in terms of plant growth, physiology, and biochemistry. Salt tolerance was determined at both germination and early seedling growth. Germination and hydroponic assays were used with exposing seeds to 0, 50, 100, 150, and 200 mM NaCl. Among seven genotypes of M. ciliaris studied, Pop1 , 355 , and 667 , were most salt tolerant. Populations like 355 and 667 showed marked tolerance to salinity at both germination and seedling stages (TI ≤1, SI
( FGP ) > 0 increased FGP ≥ 20% and SI( DW ) < 0 (DW decline ≤ 20%); at 100 mM); while Pop1 was the most salt tolerant one at seedling stages with (TI =1.79, SI( FGP ) < 0 decline of FGP ≤ 40% and with increased DW to 79%); at 150 mM NaCl). The genotypes, 306 , 773 , and M. scutellata , were moderately tolerant to salt stress depending on salt concentration. Our study may be used as an efficient strategy to reveal genetic variation in response to salt stress. This approach allows selection for desirable traits, enabling more efficient applications in breeding methods to achieve stress-tolerant M. ciliaris populations., Competing Interests: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.- Published
- 2020
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31. Anthocyanins of Coloured Wheat Genotypes in Specific Response to SalStress.
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Mbarki S, Sytar O, Zivcak M, Abdelly C, Cerda A, and Brestic M
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- Color, Pigmentation drug effects, Pigmentation physiology, Proline biosynthesis, Salinity, Stress, Physiological, Triticum anatomy & histology, Triticum growth & development, Triticum metabolism, Anthocyanins biosynthesis, Salt Tolerance physiology, Sodium Chloride pharmacology, Triticum drug effects
- Abstract
The present study investigated the effect of salt stress on the development of adaptive responses and growth parameters of different coloured wheat genotypes. The different coloured wheat genotypes have revealed variation in the anthocyanin content, which may affect the development of adaptive responses under increasing salinity stress. In the early stage of treatment with salt at a lower NaCl concentration (100 mM), anthocyanins and proline accumulate, which shows rapid development of the stress reaction. A dose-dependent increase in flavonol content was observed for wheat genotypes with more intense purple-blue pigmentation after treatment with 150 mM and 200 mM NaCl. The content of Na⁺ and K⁺ obtained at different levels of salinity based on dry weight (DW) was more than 3 times greater than the control, with a significant increase of both ions under salt stress. Overall, our results demonstrated that coloured wheat genotypes with high anthocyanin content are able to maintain significantly higher dry matter production after salt stress treatment.
- Published
- 2018
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32. Impact of Metal and Metal Oxide Nanoparticles on Plant: A Critical Review.
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Rastogi A, Zivcak M, Sytar O, Kalaji HM, He X, Mbarki S, and Brestic M
- Abstract
An increasing need of nanotechnology in various industries may cause a huge environment dispersion of nanoparticles in coming years. A concern about nanoparticles interaction with flora and fauna is raised due to a growing load of it in the environment. In recent years, several investigators have shown impact of nanoparticles on plant growth and their accumulation in food source. This review examines the research performed in the last decade to show how metal and metal oxide nanoparticles are influencing the plant metabolism. We addressed here, the impact of nanoparticle on plant in relation to its size, concentration, and exposure methodology. Based on the available reports, we proposed oxidative burst as a general mechanism through which the toxic effects of nanoparticles are spread in plants. This review summarizes the current understanding and the future possibilities of plant-nanoparticle research.
- Published
- 2017
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33. Phytochemical study and protective effect of Trigonella foenum graecum (Fenugreek seeds) against carbon tetrachloride-induced toxicity in liver and kidney of male rat.
- Author
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Mbarki S, Alimi H, Bouzenna H, Elfeki A, and Hfaiedh N
- Subjects
- Animals, Antioxidants metabolism, Flavonoids analysis, Free Radical Scavengers pharmacology, Kidney drug effects, Lipid Peroxidation drug effects, Liver drug effects, Male, Phenols analysis, Plant Extracts pharmacology, Rats, Wistar, Spectrophotometry, Ultraviolet, Thiobarbituric Acid Reactive Substances metabolism, Tissue Extracts, Carbon Tetrachloride toxicity, Kidney pathology, Liver pathology, Phytochemicals pharmacology, Protective Agents pharmacology, Seeds chemistry, Trigonella chemistry
- Abstract
Liver and kidney diseases are a global concern, therefore considerable efforts to obtain fine herbs useful as drugs from medicinal plants are currently in progress. The aim of this work was to study the antioxidant effects of previous supplementation with fenugreek seeds (FS) against carbon tetrachloride (CCl
4 ) toxicity in the liver and kidney. CCl4 toxicity was induced by one dose (i.g. 5ml CCl4 /kg of body weight, 50% CCl4 in olive oil) after 7 weeks of normal diet or diet rich in 10% of grinded fenugreek seeds (20g of pellet rat food/rat/day). 24h after the treatment with CCl4 , all animals were scarified and biological analyses were performed. A phytochemical study of fenugreek seed extract (FSE) was also carried out. The phytochemical analysis of FS and FSE revealed the presence of polyphenols (5.92±0.02mg EGA/g DM), flavonoids (0.44±0.19mg ER/g DM), polysaccharides and trace elements. DPPH radical-scavenging activity of FSE showed an EC50 of 285.59±2.01μg/ml. In vivo, CCl4 administration significantly (p<0.05) induced an increase liver and kidney biomarkers. A significant (p<0.05) alteration of the antioxidant enzyme activities was also observed. In animals pretreated with FS, the studied parameters were much less shifted. These results indicate that the supplementation with fenugreek seeds is significantly effective in protecting the liver and kidneys from CCl4 toxicity., (Copyright © 2016 Elsevier Masson SAS. All rights reserved.)- Published
- 2017
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34. Protective Effects of Pinus halepensis L. Essential Oil on Aspirin-induced Acute Liver and Kidney Damage in Female Wistar Albino Rats.
- Author
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Bouzenna H, Samout N, Amani E, Mbarki S, Tlili Z, Rjeibi I, Elfeki A, Talarmin H, and Hfaiedh N
- Subjects
- Acute Disease, Albinism, Animals, Chemical and Drug Induced Liver Injury pathology, Female, Kidney metabolism, Kidney pathology, Kidney Diseases chemically induced, Kidney Diseases pathology, Liver metabolism, Liver pathology, Oils, Volatile administration & dosage, Oils, Volatile isolation & purification, Oxidative Stress drug effects, Protective Agents administration & dosage, Protective Agents isolation & purification, Rats, Rats, Wistar, Aspirin adverse effects, Chemical and Drug Induced Liver Injury prevention & control, Kidney drug effects, Kidney Diseases prevention & control, Liver drug effects, Oils, Volatile pharmacology, Pinus chemistry, Protective Agents pharmacology
- Abstract
Aromatic and medicinal plants are sources of natural antioxidants thanks to their secondary metabolites. Administration of Pinus halepensis L. (Pinaceae family) in previous studies was found to alleviate deleterious effects of aspirin-induced damage on liver and kidney. The present study, carried out on female rats, evaluates the effects of P. halepensis L. essential oil (EOP) on aspirin (A)-induced damage to liver and kidney. The animals used in this study were rats (n=28) divided into 4 groups of 7 each: (1) a control group (C); (2) a group given NaCl for 56 days then treated with (A) (600 mg/kg) for 4 days (A); (3) a group fed with (EOP) for 56 days then (A) for 4 days; and a group fed with only (EOP) for 56 days and given NaCl for 4 days. Estimations of biochemical parameters in blood were determined using kit methods (Spinreact). Lipid peroxidation levels (TBARS), superoxide dismutase (SOD) and catalase (CAT), glutathione peroxidase (GPx) activities were determined. Histopathological study was done by immersing pieces of both organs in a fixative solution followed by paraffin embeddeding and hematoxylin-eosin staining. Under our experimental conditions, Aspirin at dose 600 mg/kg body weight induced an increase of serum biochemical parameters as well as an oxidative stress in both organs. An increase occurred in TBARS by 108% and 55%, a decrease in SOD by 78% and 53%, CAT by 53% and 78%, and GPx by 78% and 51% in liver and kidney, respectively, compared to control. Administration of EOP given to rats enabled correction in these parameters. It could be concluded that the treatment with P. halepensis L. essential oil inhibited aspirin-induced liver and kidney damage.
- Published
- 2016
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35. Eucalyptus globulus extract protects upon acetaminophen-induced kidney damages in male rat.
- Author
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Dhibi S, Mbarki S, Elfeki A, and Hfaiedh N
- Subjects
- Animals, Kidney Diseases pathology, Male, Oxidative Stress, Plant Extracts therapeutic use, Plant Leaves, Rats, Rats, Wistar, Acetaminophen toxicity, Analgesics, Non-Narcotic toxicity, Eucalyptus, Kidney Diseases chemically induced, Kidney Diseases prevention & control, Phytotherapy
- Abstract
Plants have historically been used in treating many diseases. Eucalyptus globules, a rich source of bioactive compounds, and have been shown to possess antioxidative properties. The purpose of this study, carried out on male Wistar rats, was to evaluate the beneficial effects of Eucalyptus globulus extract upon acetaminophen-induced damages in kidney. Our study is realized in the Department of Biology, Faculty of Sciences of Sfax (Tunisia). 32 Wistar male rats; were divided into 4 batches: a control group (n=8), a group of rats treated with acetaminophen (900 mg/kg) by intraperitoneal injection during 4 days (n=8), a group receiving Eucalyptus globulus extract (130 mg of dry leaves/kg/day) in drinking water during 42 days after 2 hours of acetaminophen administration (during 4 days) (n=8) and group received only Eucalyptus (n=8) during 42 days. After 6 weeks, animals from each group were rapidly sacrificed by decapitation. Blood serum was obtained by centrifugation. Under our experimental conditions, acetaminophen poisoning resulted in an oxidative stress evidenced by statistically significant losses in the activities of catalase (CAT), superoxide-dismutase (SOD), glutathione-peroxidase (GPX) activities and an increase in lipids peroxidation level in renal tissue of acetaminophen-treated group compared with the control group. Acetaminophen also caused kidney damage as evident by statistically significant (p<0.05) increase in levels of creatinine and urea and decreased levels of uric acid and proteins in blood. Histological analysis demonstrated alteration of proximal tubules, atrophy of the glomerule and dilatation of urinary space. Previous administration of plant extract is found to alleviate this acetaminophen-induced damage.
- Published
- 2014
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36. Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats.
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Alimi H, Mbarki S, Barka ZB, Feriani A, Bouoni Z, Hfaeidh N, Sakly M, Tebourbi O, and Rhouma KB
- Subjects
- Animals, Anti-Ulcer Agents pharmacology, Antioxidants chemistry, Antioxidants pharmacology, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, Ethanol adverse effects, Flavonoids chemistry, Male, Phenol chemistry, Phytotherapy methods, Plant Extracts chemistry, Polysaccharides chemistry, Rats, Rats, Wistar, Spectrophotometry, Infrared, Spectroscopy, Fourier Transform Infrared, Tannins chemistry, Time Factors, Plant Bark chemistry, Plant Extracts pharmacology, Plant Roots chemistry, Rhus chemistry, Ulcer drug therapy
- Abstract
Rhus tripartitum (sumac) is an Anacardiaceae tree with a wide phytotherapeutic application including the use of its roots in the management of gastric ulcer. In the present study the Rhus tripartitum root barks extract (RTE) was phytochemical studied, in vitro tested for their potential antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and reducing power assay and in vivo evaluated for its ability to prevent ethanol-induced gastric ulcer in rats. The RTE was rich in phenolics, flavonoids, tannins and polysaccharide contents and exhibited a low but not weak in vitro antioxidant activity when compared with (+)-catechin. Pre-treatment with RTE at oral doses 50, 200 and 400 mg/kg body weight was found to provide a dose-dependent protection against ethanol-induced ulcer by averting the deep ulcer lesions of the gastric epithelium, by reducing gastric juice and acid output, by enhancing gastric mucus production by preserving normal antioxidant enzymes activities, and inhibiting the lipid peroxidation. The antiulcerogenic activity of RTE might be due to a possible synergistic antioxidant and antisecretory effects.
- Published
- 2013
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37. [Acute myocardial infarction during pregnancy complicated by acute adrenal failure].
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Mghaieth F, Ayari J, Mbarki S, Mizouni H, Sfar E, Mourali MS, Mnif E, Chelli H, and Mechmeche R
- Subjects
- Abortion, Therapeutic, Acute Disease, Adrenal Insufficiency diagnosis, Adrenal Insufficiency therapy, Adult, Electrocardiography, Female, Humans, Myocardial Infarction diagnosis, Pregnancy, Pregnancy Complications therapy, Adrenal Insufficiency complications, Myocardial Infarction complications, Pregnancy Complications etiology
- Published
- 2012
38. Evaluation of Opuntia ficus indica f. inermis fruit juice hepatoprotective effect upon ethanol toxicity in rats.
- Author
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Alimi H, Hfaeidh N, Mbarki S, Bouoni Z, Sakly M, and Ben Rouma K
- Subjects
- Animals, Beverages, Chemical and Drug Induced Liver Injury etiology, Fruit chemistry, Male, Rats, Rats, Wistar, Treatment Outcome, Caryophyllaceae chemistry, Chemical and Drug Induced Liver Injury metabolism, Chemical and Drug Induced Liver Injury prevention & control, Ethanol toxicity, Phytotherapy methods, Plant Extracts administration & dosage, Reactive Oxygen Species metabolism
- Abstract
The aim of our present study is to investigate the effect of Opuntia ficus indica f. inermis prickly pear juice (PPJ) against ethanol-induced liver injury in rats. Chronic ethanol administration (3 g/kg b.w.) during 90 days to Wistar rats, significantly (p < 0.01) increased the liver lipid and protein oxidation, reduced the glutathione content and the activities of liver antioxidant enzymes such as superoxide dismutase, catalase, glutathione peroxidase and conversely elevated the liver injury biochemical markers like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl transferase, lactate dehydrogenase, cholesterol, triglycerides and caused a severe histopathologic injuries. Conversely pre-treatment of ethanol-fed rats with PPJ (20 and 40 ml/kg b.w., orally), interestingly reduced liver lipid and protein oxidation, histopathologic lesions and inhibited the alterations of antioxidant enzymes and the release of biochemical markers. The hepatoprotective effect of PPJ could be due to their capacity to end free radicals chain reactions or to enhance the endogenous antioxidants activities.
- Published
- 2012
- Full Text
- View/download PDF
39. [Contrast-induced nephropathy after cardiac catheterization: a prospective study of 180 patients].
- Author
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Mghaieth F, Ayari J, Ben Rejeb R, Mbarki S, Farhati A, Larbi N, Boussaada R, Mourali MS, and Mechmeche R
- Subjects
- Adult, Aged, Aged, 80 and over, Coronary Angiography, Female, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Acute Kidney Injury chemically induced, Cardiac Catheterization, Contrast Media adverse effects
- Abstract
Background: Contrast-induced nephropathy (CIN) is associated with an increased cardiovascular morbi-mortality. Little is known about the incidence and risk factors of CIN after cardiac catheterization in Tunisian patients., Aim: To determine the incidence of CIN and its predictors after coronary angiography as well as its prognostic and therapeutic repercussions in a Tunisian patients' cohort., Methods: In this prospective single center study, 180 consecutive patients who underwent cardiac catheterization were enrolled; all patients were followed-up for 3 months., Results: The incidence of CIN defined as an absolute increase in serum creatinine ³ 5 mg/l (44μmol/l) and/or a relative increase in serum creatinine ³ 25%, was 17.2%. In multivariate logistic regression, independent predictors of CIN were: diabetes mellitus (Odds Ratio (OR)=2.26 ; 95% confidence interval (95%CI) : 1.29- 3.98, p=0.005), creatinine clearance < 80ml/mn (OR=2.87 ; 95%CI : 1.59-5.19, p<0.001), left ventricular ejection fraction (LVEF) < 45% (OR=2.03 ; 95%CI : 1.22-3.39, p=0.007) and use of a volume of contrast media > 90ml (1.72 ; 95%CI : 0.99-2.99, p=0.05). Perprocedural hypotension was the strongest independent predictor of CIN in our study (OR=3.99; 95% CI: 1.65-9.66, p=0.002). CIN was totally regressive within one month in 27 patients (86.7%) while 3 patients (10%) had a residual renal dysfunction at the end of the follow-up period (3 months)., Conclusion: More than one angiocoronarography on 6 resulted in CIN in our population. CIN affects cardiovascular prognosis even if renal function normalization is usually obtained within one month after the investigation. Besides identifying risk factors of CIN in order to apply preventive measures in risky patients, we stress the necessity of insuring a good hemodynamic status while achieving the procedure.
- Published
- 2012
40. Contrasting effects of municipal compost on alfalfa growth in clay and in sandy soils: N, P, K, content and heavy metal toxicity.
- Author
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Mbarki S, Labidi N, Mahmoudi H, Jedidi N, and Abdelly C
- Subjects
- Clay, Aluminum Silicates, Medicago sativa growth & development, Metals, Heavy toxicity, Nitrogen analysis, Phosphorus analysis, Potassium analysis, Silicon Dioxide, Soil analysis
- Abstract
The limits for loading soils with Tunisian urban compost for cultivating Medicago sativa were determined in a 6-month experiment in a greenhouse. Mature municipal solid waste compost (MSWC) from Tunis city was applied to clay and sandy soils from cultivated fields at rates equivalent to 40, 80, 120tha(-1). In the absence of MSWC, the shoot biomass (dry weight) cumulated over four cuts was 2-2.5 lower in sandy soil than in clay soil. It was 20-25% augmented upon MSWC addition in clay soil, independently of MSWC dose. The opposite trend was observed in sandy soil, the shoot yields being diminished by MSWC in a dose dependent manner. In MSWC-amended clay soil but not in sandy soil, Cd, Cu, Zn, and Pb concentrations in shoots remained below or close to the tolerated values according to EEC norms. The MSWC might be used as conditioner for clay soil, but not for sandy soil.
- Published
- 2008
- Full Text
- View/download PDF
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