18 results on '"Mbah JA"'
Search Results
2. Antiplasmodial agents from the leaves of Glossocalyx brevipes.
- Author
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Mbah JA, Tane P, Ngadjui BT, Connolly JD, Okunji CC, Iwu MM, and Schuster BM
- Published
- 2004
3. Bioassay-guided discovery of antibacterial agents: in vitro screening of Peperomia vulcanica, Peperomia fernandopoioana and Scleria striatinux
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Mbah James A, Ngemenya Moses N, Abawah Ashime, Babiaka Smith B, Nubed Lina N, Nyongbela Kennedy D, Lemuh Njimoh, and Efange Simon MN
- Subjects
Resistance ,Medicinal plants ,Antibacterial compound ,Toxicity ,Therapeutics. Pharmacology ,RM1-950 ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Abstract Background The global burden of bacterial infections is high and has been further aggravated by increasing resistance to antibiotics. In the search for novel antibacterials, three medicinal plants: Peperomia vulcanica, Peperomia fernandopoioana (Piperaceae) and Scleria striatinux (Cyperaceae), were investigated for antibacterial activity and toxicity. Methods Crude extracts of these plants were tested by the disc diffusion method against six bacterial test organisms followed by bio-assay guided fractionation, isolation and testing of pure compounds. The minimum inhibitory (MIC) and minimum bactericidal (MBC) concentrations were measured by the microdilution method. The acute toxicity of the active extracts and cytotoxicity of the active compound were performed in mice and mammalian cells, respectively. Results The diameter of the zones of inhibition (DZI) of the extracts ranged from 7–13 mm on Escherichia coli and Staphylococcus aureus of which the methylene chloride:methanol [1:1] extract of Scleria striatinux recorded the highest activity (DZI = 13 mm). Twenty-nine pure compounds were screened and one, Okundoperoxide, isolated from S. striatinux, recorded a DZI ranging from 10–19 mm on S. aureus. The MICs and MBCs indicated that the Peperomias had broad-spectrum bacteriostatic activity. Toxicity tests showed that Okundoperoxide may have a low risk of toxicity with an LC50 of 46.88 μg/mL. Conclusions The antibacterial activity of these plants supports their use in traditional medicine. The pure compound, Okundoperoxide, may yield new antibacterial lead compounds following medicinal chemistry exploration.
- Published
- 2012
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4. New flavanone and other constituents from erythrina senegalensis A. DC. (fabaceae).
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Tadjong Tcho A, Djouaka Bavoua JL, Ngouonpe Wembe A, Gompe Bobda EG, Majoumo F, Leuche JM, Ndonfack Tiofack E, Mbah JA, and Toze FAA
- Abstract
The chemical investigation of the methanol trunk bark extract of Erythrina senegalensis led to the isolation of a new flavanone, 5,7,4'-trihydroxy-3',5'-bis(3-methylbutadienyl)flavanone (trivially named senegalensisnone) ( 1 ), together with seven known compounds, abyssinone-V-4'- O -methyl ether ( 2 ), abyssinone V ( 3 ), Calopocarpin ( 4 ), genistein (5 ) mixture of stigmasterol ( 6 ) and β -sitosterol ( 7 ) and β -sitosterol-3- O - β -D-glucopyranoside ( 8 ). The structures of the isolates were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. The absolute configuration of 1 was deduced based on comparison of its experimental CD with that of similar compound. All the compounds were tested for their antibacterial, antifungal and antioxidant activities. Compound 4 displayed weak antibacterial activity against Salmonella enteritidis with MIC value of 62.5 μ g/mL. All the isolates were found to be inactive as antioxidant agents in the DPPH, ABTS and FRAP assays.
- Published
- 2024
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5. In Vitro Synergistic Activity of Combinations of Tetrahydroisoquinolines and Treatment Antibiotics against Multidrug-Resistant Salmonella .
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Ndip RA, Hanna JN, Mbah JA, Ghogomu SM, and Ngemenya MN
- Abstract
The global burden of Salmonella infections remains high due to the emergence of multidrug resistance to all recommended treatment antibiotics. Tetrahydroisoquinolines (THIQs) have demonstrated promising activity against multidrug-resistant (MDR) Salmonella Typhi. Hence, their interaction with treatment antibiotics was investigated for possible synergy. Twenty combinations of five THIQs ( 1 , 2 , 3 , 4, and 5 ) and four antibiotics were tested against each of 7 Salmonella isolates by the checkerboard method giving a total of 140 assays performed. Fractional inhibitory concentration indices (FICIs) were calculated, and isobolograms were plotted. In terms of FICI, synergism ranged from 0.078 to 0.5 and the highest magnitude (0.078) was recorded for chloramphenicol-THIQ 1 combination. In a total of 140 antibiotics-THIQs combination assays, 27 were synergistic (17%), 42 were additive (30%), 11 were antagonistic (7.8%), and 60 were indifferent (42%). The synergistic activity recorded for each antibiotic class in combination based on the total of 7 bacterial isolates tested ranged from 14.29% to 71.43%; the highest percentage was recorded for two combinations (chloramphenicol or sulphamethoxazole with THIQ 1 ). Ciprofloxacin-THIQ 1 combination showed additivity on all bacteria isolates tested (100%). Overall, THIQ 1 was the most synergistic and most additive in combination with three antibiotics (ampicillin, chloramphenicol, or sulphamethoxazole-trimethoprim). Some combinations of the THIQs and treatment antibiotics have shown high synergism which could potentially be efficacious against multidrug-resistant S. Typhi, hence this interaction should be further studied in vivo ., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2023 Rita Ayuk Ndip et al.)
- Published
- 2023
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6. The use of minimal topological differences to inspire the design of novel tetrahydroisoquinoline analogues with antimalarial activity.
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Ngo Hanna J, Nziko VPN, Ntie-Kang F, Mbah JA, and Toze FAA
- Abstract
A quantitative structure-activity relationship (QSAR) study was conducted using nineteen previously synthesized, and tested 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinolines with proven in vitro activities against Plasmodium falciparum . In order to computationally design and screen potent antimalarial agents, these compounds with known biological activity ranging from 0.697 to 35.978 μM were geometry optimized at the B3LYP/6-311 + G(d,p) level of theory, using the Gaussian 09W software. To calculate the topological differences, the series of the nineteen compounds was superimposed and a hypermolecule obtained with s ¯ = 17 and 20 vertices. Other molecular descriptors were considered in order to build a highly predictive QSAR model. These include the minimal topological differences (MTD), LogP, two dimensional polarity surface area (TDPSA), dipole moment (μ), chemical hardness (η), electrophilicity (ω), potential energy (E
p ), electrostatic energy (Eele ) and number of rotatable bonds (NRB). By using a training set composed of 15 randomly selected compounds from this series, several QSAR equations were derived. The QSAR equations obtained were then used to attempt to predict the IC50 values of 4 remaining compounds in a test (or validation) set. Ten analogues were proposed by a fragment search of a fragment library containing the pharmacophore model of the active compounds contained in the training set. The most active proposed analogue showed a predicted activity within the lower micromolar range., Competing Interests: The authors declare no conflict of interest., (© 2021 The Author(s).)- Published
- 2021
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7. Alkaloids with Anti-Onchocercal Activity from Voacanga africana Stapf (Apocynaceae): Identification and Molecular Modeling.
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Babiaka SB, Simoben CV, Abuga KO, Mbah JA, Karpoormath R, Ongarora D, Mugo H, Monya E, Cho-Ngwa F, Sippl W, Loveridge EJ, and Ntie-Kang F
- Subjects
- Alkaloids pharmacology, Animals, Humans, Onchocerca pathogenicity, Onchocerciasis parasitology, Alkaloids chemistry, Onchocerca drug effects, Onchocerciasis drug therapy, Voacanga chemistry
- Abstract
A new iboga-vobasine-type isomeric bisindole alkaloid named voacamine A ( 1 ), along with eight known compounds-voacangine ( 2 ), voacristine ( 3 ), coronaridine ( 4 ), tabernanthine ( 5 ), iboxygaine ( 6 ), voacamine ( 7 ), voacorine ( 8 ) and conoduramine ( 9 )-were isolated from the stem bark of Voacangaafricana . The structures of the compounds were determined by comprehensive spectroscopic analyses. Compounds 1 , 2 , 3 , 4 , 6 , 7 and 8 were found to inhibit the motility of both the microfilariae (Mf) and adult male worms of Onchocerca ochengi , in a dose-dependent manner, but were only moderately active on the adult female worms upon biochemical assessment at 30 μM drug concentrations. The IC
50 values of the isolates are 2.49-5.49 µM for microfilariae and 3.45-17.87 µM for adult males. Homology modeling was used to generate a 3D model of the O. ochengi thioredoxin reductase target and docking simulation, followed by molecular dynamics and binding free energy calculations attempted to offer an explanation of the anti-onchocercal structure-activity relationship (SAR) of the isolated compounds. These alkaloids are new potential leads for the development of antifilarial drugs. The results of this study validate the traditional use of V. africana in the treatment of human onchocerciasis.- Published
- 2020
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8. Filaricidal activities on Onchocerca ochengi and Loa loa, toxicity and phytochemical screening of extracts of Tragia benthami and Piper umbellatum.
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Cho-Ngwa F, Monya E, Azantsa BK, Manfo FP, Babiaka SB, Mbah JA, and Samje M
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- Animals, Cell Line, Cell Survival drug effects, Filaricides chemistry, Filaricides toxicity, Haplorhini, Plant Extracts chemistry, Plant Extracts toxicity, Euphorbiaceae chemistry, Filaricides pharmacology, Loa drug effects, Onchocerca drug effects, Piper chemistry, Plant Extracts pharmacology
- Abstract
Background: Onchocerciasis is the world's second leading infectious cause of blindness. Its control is currently hampered by the lack of a macrofilaricidal drug and by severe adverse events observed when the lone recommended microfilaricide, ivermectin is administered to individuals co-infected with Loa loa. Therefore, there is the need for a safe and effective macrofilaricidal drug that will be able to cure the infection and break transmission cycles, or at least, an alternative microfilaricide that does not kill L. loa microfilariae (mf)., Methods: Fourteen extracts from two medicinal plants, Tragia benthami and Piper umbellatum were screened in vitro against Onchocerca ochengi parasite and L. loa mf. Activities of extracts on male worms and microfilariae were assessed by motility reduction, while MTT/Formazan assay was used to assess biochemically the death of female worms. Cytotoxicity and acute toxicity of active extracts were tested on monkey kidney cells and Balb/c mice, respectively., Results: At 500 μg/mL, all extracts showed 100 % activity on Onchocerca ochengi males and microfilariae, while 9 showed 100 % activity on female worms. The methylene chloride extract of Piper umbellatum leaves was the most active on adult male and female worms (IC50s: 16.63 μg/mL and 35.65 μg/mL, respectively). The three most active extracts on Onchocerca ochengi females were also highly active on Loa loa microfilariae, with IC50s of 35.12 - 13.9 μg/mL. Active extracts were generally more toxic to the worms than to cells and showed no acute toxicity to Balb/c mice. Phytochemical screening revealed the presence of saponins, steroids, tannins and flavanoids in the promising extracts., Conclusions: These results unfold potential sources of novel anti-Onchocerca lead compounds and validate the traditional use of the plants in onchocerciasis treatment.
- Published
- 2016
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9. The potential of anti-malarial compounds derived from African medicinal plants, part III: an in silico evaluation of drug metabolism and pharmacokinetics profiling.
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Onguéné PA, Ntie-Kang F, Mbah JA, Lifongo LL, Ndom JC, Sippl W, and Mbaze LM
- Abstract
Background: Malaria is an endemic disease affecting many countries in Tropical regions. In the search for compound hits for the design and/or development of new drugs against the disease, many research teams have resorted to African medicinal plants in order to identify lead compounds. Three-dimensional molecular models were generated for anti-malarial compounds of African origin (from 'weakly' active to 'highly' active), which were identified from literature sources. Selected computed molecular descriptors related to absorption, distribution, metabolism, excretion and toxicity (ADMET) of the phytochemicals have been analysed and compared with those of known drugs in order to access the 'drug-likeness' of these compounds., Results: In the present study, more than 500 anti-malarial compounds identified from 131 distinct medicinal plant species belonging to 44 plant families from the African flora have been considered. On the basis of Lipinski's 'Rule of Five', about 70% of the compounds were predicted to be orally bioavailable, while on the basis of Jorgensen's 'Rule of Three', a corresponding >80% were compliant. An overall drug-likeness parameter indicated that approximately 55% of the compounds could be potential leads for the development of drugs., Conclusions: From the above analyses, it could be estimated that >50% of the compounds exhibiting anti-plasmodial/anti-malarial activities, derived from the African flora, could be starting points for drug discovery against malaria. The 3D models of the compounds have been included as an accompanying file and could be employed in virtual screening.
- Published
- 2014
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10. Anti-onchocerca Metabolites from Cyperus articulatus: Isolation, In Vitro Activity and In Silico 'Drug-Likeness'.
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Metuge JA, Babiaka SB, Mbah JA, Ntie-Kang F, Ayimele GA, and Cho-Ngwa F
- Abstract
The aims of this investigation were to isolate active ingredients from the roots/rhizomes of Cyperus articulatus used as herbal medicine in Cameroon for the treatment of human onchocerciasis and to assess the efficacy of the metabolites on the Onchocerca worm. The antifilarial activity was evaluated in vitro on microfilariae (Mfs) and adult worms of the bovine derived Onchocerca ochengi, a close relative of Onchocerca volvulus. Cytotoxicity was assessed in vitro on monkey kidney epithelial cells. The structures of the active compounds were determined using spectroscopic methods and their drug-likeness evaluated using Lipinski parameters. Two secondary metabolites, AMJ1 [containing mustakone (1) as the major component] and linoleic acid or (9Z,12Z)-octadeca-9,12-dienoic acid (2) were isolated. Both compounds were found to kill both the microfilariae and adult worms of O. ochengi in a dose dependent manner. The IC50s for AMJ1 were 15.7 µg/mL for Mfs, 17.4 µg/mL for adult males and 21.9 µg/mL for adult female worms while for linoleic acid the values were, 15.7 µg/mL for Mfs, 31.0 µg/mL for adult males and 44.2 µg/mL for adult females. The present report provides the first ever evidence of the anti-Onchocerca efficacy of AMJ1 and linoleic acid. Thus, these secondary metabolites may provide a lead for design and development of new antifilarial agents.
- Published
- 2014
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11. Anti-Onchocerca activity and phytochemical analysis of an essential oil from Cyperus articulatus L.
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Metuge JA, Nyongbela KD, Mbah JA, Samje M, Fotso G, Babiaka SB, and Cho-Ngwa F
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- Animals, Cameroon, Cattle, Cell Line, Epithelial Cells drug effects, Female, Filaricides chemistry, Filaricides toxicity, Haplorhini, Humans, Kidney cytology, Kidney drug effects, Male, Mice, Oils, Volatile chemistry, Oils, Volatile toxicity, Onchocerciasis parasitology, Plant Extracts chemistry, Plant Extracts toxicity, Cyperus chemistry, Filaricides pharmacology, Oils, Volatile pharmacology, Onchocerca drug effects, Onchocerciasis drug therapy, Plant Extracts pharmacology
- Abstract
Background: The lack of a safe and effective adult worm drug and the emergence of resistant animal parasite strains to the only recommended drug, the microfilaricide, ivermectin put many at risk of the devastating effects of the onchocerciasis. The present study was undertaken to investigate the acclaimed anti-Onchocerca activity of the roots/rhizomes of Cyperus articulatus in the traditional treatment of onchocerciasis in North Western Cameroon and to assess the plant as a new source of potential filaricidal lead compounds., Methods: Crude extracts were prepared from the dried plant parts using hexane, methylene chloride and methanol. The antifilarial activity was evaluated in vitro on microfilariae (Mfs) and adult worms of the bovine derived Onchocerca ochengi, a close relative of Onchocerca volvulus. The viabilities of microfilariae and adult male worms were determined based on motility reduction, while for the adult female worms the viability was based on the standard MTT/formazan assay. Cytotoxicity of the active extract was assessed on monkey kidney epithelial cells in vitro and the selectivity indices (SI) were determined. Acute toxicity of the promising extract was investigated in mice. Chemical composition of the active extract was unraveled by GC/MS analysis., Results: Only the hexane extract, an essential oil exhibited anti-Onchocerca activity. The oil killed both the microfilariae and adult worms of O. ochengi in a dose manner dependently, with IC50s of 23.4 μg/ml on the Mfs, 23.4 μg/ml on adult male worms and 31.25 μg/ml on the adult female worms. Selectivity indices were 4, 4, and 2.99 for Mfs, adult males and adult females, respectively. At a single limit dose of 2000 mg/kg body weight, none of 6 mice that received the essential oil by gavage died. GC/MS analysis revealed the presence of terpenoids, hydrocarbons and fatty acids or fatty acid derivatives as components of the oil., Conclusions: The essential oil from the roots/rhizomes of Cyperus articulatus is active against O. ochengi microfilariae and adult worms in vitro in a dose dependent manner, hence may provide a source of new anti-filarial compounds. The results also support the traditional use of C. articulatus in the treatment of human onchocerciasis.
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- 2014
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12. AfroDb: a select highly potent and diverse natural product library from African medicinal plants.
- Author
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Ntie-Kang F, Zofou D, Babiaka SB, Meudom R, Scharfe M, Lifongo LL, Mbah JA, Mbaze LM, Sippl W, and Efange SM
- Subjects
- Africa, Biological Products analysis, Computer-Aided Design, Databases, Factual, Plants, Medicinal chemistry
- Abstract
Computer-aided drug design (CADD) often involves virtual screening (VS) of large compound datasets and the availability of such is vital for drug discovery protocols. We assess the bioactivity and "drug-likeness" of a relatively small but structurally diverse dataset (containing >1,000 compounds) from African medicinal plants, which have been tested and proven a wide range of biological activities. The geographical regions of collection of the medicinal plants cover the entire continent of Africa, based on data from literature sources and information from traditional healers. For each isolated compound, the three dimensional (3D) structure has been used to calculate physico-chemical properties used in the prediction of oral bioavailability on the basis of Lipinski's "Rule of Five". A comparative analysis has been carried out with the "drug-like", "lead-like", and "fragment-like" subsets, as well as with the Dictionary of Natural Products. A diversity analysis has been carried out in comparison with the ChemBridge diverse database. Furthermore, descriptors related to absorption, distribution, metabolism, excretion and toxicity (ADMET) have been used to predict the pharmacokinetic profile of the compounds within the dataset. Our results prove that drug discovery, beginning with natural products from the African flora, could be highly promising. The 3D structures are available and could be useful for virtual screening and natural product lead generation programs.
- Published
- 2013
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13. Assessing the pharmacokinetic profile of the CamMedNP natural products database: an in silico approach.
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Ntie-Kang F, Mbah JA, Lifongo LL, Owono Owono LC, Megnassan E, Meva'a Mbaze L, Judson PN, Sippl W, and Efange SM
- Abstract
Background: Drug metabolism and pharmacokinetic (DMPK) assessment has come to occupy a place of interest during the early stages of drug discovery today. Computer-based methods are slowly gaining ground in this area and are often used as initial tools to eliminate compounds likely to present uninteresting pharmacokinetic profiles and unacceptable levels of toxicity from the list of potential drug candidates, hence cutting down the cost of the discovery of a drug., Results: In the present study, we present an in silico assessment of the DMPK profile of our recently published natural products database of 1,859 unique compounds derived from 224 species of medicinal plants from the Cameroonian forest. In this analysis, we have used 46 computed physico-chemical properties or molecular descriptors to predict the absorption, distribution, metabolism and elimination (ADME) of the compounds. This survey demonstrated that about 50% of the compounds within the Cameroonian medicinal plant and natural products (CamMedNP) database are compliant, having properties which fall within the range of ADME properties of >95% of currently known drugs, while >73% of the compounds have ≤2 violations. Moreover, about 72% of the compounds within the corresponding 'drug-like' subset showed compliance., Conclusions: In addition to the previously verified levels of 'drug-likeness' and the diversity and the wide range of measured biological activities, the compounds in the CamMedNP database show interesting DMPK profiles and, hence, could represent an important starting point for hit/lead discovery from medicinal plants in Africa.
- Published
- 2013
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14. In silico drug metabolism and pharmacokinetic profiles of natural products from medicinal plants in the Congo basin.
- Author
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Ntie-Kang F, Lifongo LL, Mbah JA, Owono Owono LC, Megnassan E, Mbaze LM, Judson PN, Sippl W, and Efange SM
- Abstract
Purpose: Drug metabolism and pharmacokinetics (DMPK) assessment has come to occupy a place of interest during the early stages of drug discovery today. The use of computer modelling to predict the DMPK and toxicity properties of a natural product library derived from medicinal plants from Central Africa (named ConMedNP). Material from some of the plant sources are currently employed in African Traditional Medicine., Methods: Computer-based methods are slowly gaining ground in this area and are often used as preliminary criteria for the elimination of compounds likely to present uninteresting pharmacokinetic profiles and unacceptable levels of toxicity from the list of potential drug candidates, hence cutting down the cost of discovery of a drug. In the present study, we present an in silico assessment of the DMPK and toxicity profile of a natural product library containing ~3,200 compounds, derived from 379 species of medicinal plants from 10 countries in the Congo Basin forests and savannas, which have been published in the literature. In this analysis, we have used 46 computed physico-chemical properties or molecular descriptors to predict the absorption, distribution, metabolism and elimination and toxicity (ADMET) of the compounds., Results: This survey demonstrated that about 45% of the compounds within the ConMedNP compound library are compliant, having properties which fall within the range of ADME properties of 95% of currently known drugs, while about 69% of the compounds have ≤ 2 violations. Moreover, about 73% of the compounds within the corresponding "drug-like" subset showed compliance., Conclusions: In addition to the verified levels of "drug-likeness", diversity and the wide range of measured biological activities, the compounds from medicinal plants in Central Africa show interesting DMPK profiles and hence could represent an important starting point for hit/lead discovery.
- Published
- 2013
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15. CamMedNP: building the Cameroonian 3D structural natural products database for virtual screening.
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Ntie-Kang F, Mbah JA, Mbaze LM, Lifongo LL, Scharfe M, Hanna JN, Cho-Ngwa F, Onguéné PA, Owono Owono LC, Megnassan E, Sippl W, and Efange SM
- Subjects
- Computer-Aided Design, Drug Design, Molecular Conformation, Plants classification, Biological Products chemistry, Databases, Factual, Plants chemistry, User-Computer Interface
- Abstract
Background: Computer-aided drug design (CADD) often involves virtual screening (VS) of large compound datasets and the availability of such is vital for drug discovery protocols. We present CamMedNP - a new database beginning with more than 2,500 compounds of natural origin, along with some of their derivatives which were obtained through hemisynthesis. These are pure compounds which have been previously isolated and characterized using modern spectroscopic methods and published by several research teams spread across Cameroon., Description: In the present study, 224 distinct medicinal plant species belonging to 55 plant families from the Cameroonian flora have been considered. About 80 % of these have been previously published and/or referenced in internationally recognized journals. For each compound, the optimized 3D structure, drug-like properties, plant source, collection site and currently known biological activities are given, as well as literature references. We have evaluated the "drug-likeness" of this database using Lipinski's "Rule of Five". A diversity analysis has been carried out in comparison with the ChemBridge diverse database., Conclusion: CamMedNP could be highly useful for database screening and natural product lead generation programs.
- Published
- 2013
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16. Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity.
- Author
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Efange SM, Brun R, Wittlin S, Connolly JD, Hoye TR, McAkam T, Makolo FL, Mbah JA, Nelson DP, Nyongbela KD, and Wirmum CK
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- Antimalarials chemistry, Chloroquine pharmacology, Drug Resistance drug effects, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Roots chemistry, Plasmodium falciparum drug effects, Sesquiterpenes chemistry, Stereoisomerism, Antimalarials isolation & purification, Antimalarials pharmacology, Cyperaceae chemistry, Plants, Medicinal chemistry, Sesquiterpenes isolation & purification, Sesquiterpenes pharmacology
- Abstract
Okundoperoxide (1) was isolated by bioassay-guided fractionation of extracts from Scleria striatinux (syn. S. striatonux). The compound contains a cyclic endoperoxide structural moiety and possesses moderate antimalarial activity.
- Published
- 2009
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17. Two chromones from Peperomia vulcanica.
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Mbah JA, Tchuendem MH, Tane P, and Sterner O
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- Chromones chemistry, Molecular Structure, Spectrum Analysis, Chromones isolation & purification, Piperaceae chemistry
- Abstract
TWO CHROMONES: 5-hydroxy-2-(14'-(E)-nonadecenyl) chromone (1) and 5-hydroxy-2-[12'-(3",4"-methylenedioxyphenyl)dodecanyl] chromone (2), together with six known compounds have been isolated from Peperomia vulcanica Baker & C. H. Wright (Piperaceae). Their structures were determined by spectroscopic analysis including 2D NMR techniques.
- Published
- 2002
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18. Anti-plasmodial sesquiterpenoids from the African Reneilmia cincinnata.
- Author
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Tchuendem MH, Mbah JA, Tsopmo A, Ayafor JF, Sterner O, Okunjic CC, Iwu MM, and Schuster BM
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- Animals, Antimalarials chemistry, Fruit chemistry, Nuclear Magnetic Resonance, Biomolecular, Plant Extracts chemistry, Plant Extracts isolation & purification, Plant Extracts pharmacology, Plasmodium falciparum drug effects, Plasmodium falciparum growth & development, Sesquiterpenes chemistry, Antimalarials isolation & purification, Antimalarials pharmacology, Sesquiterpenes isolation & purification, Sesquiterpenes pharmacology, Zingiberales chemistry
- Abstract
A new isodaucane sesquiterpenoid, 6,7,10-trihydoxyisodaucane, was isolated from the fruits of Reneilmia cincinnata, together with the known sesquiterpenoids oplodiol, oplopanone, 5E,10(14)-germacradien-1 beta, 4 beta-diol, 1(10)E,5E-germacradien-4 alpha-ol and eudesman-1,4,7-triol. A large amount of 5-hydroxy-3,7,4'-trimethoxyflavone was also isolated. Their structures were established by NMR techniques using 1D and 2D experiments. Three of the known sesquirernenoids exhibited noteworthy anti-plasmodial activity against Plasmodium falciparum strains.
- Published
- 1999
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