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428 results on '"Mazzotta, Cosimo"'

9. Customized corneal allogenic intrastromal ring segments (CAIRS) for keratoconus with decentered asymmetric cone

Author

Jacob, Soosan, Agarwal, Amar, Awwad, Shady, Mazzotta, Cosimo, Parashar, Parnika, and Jambulingam, Sambath

Subjects
Health
Abstract

Byline: Soosan. Jacob, Amar. Agarwal, Shady. Awwad, Cosimo. Mazzotta, Parnika. Parashar, Sambath. Jambulingam Corneal allogenic intrastromal ring segments (CAIRS) refer to the intracorneal placement of fresh,unprocessed, processed, preserved, or packaged [...]

Published
2023

11. Infectious Keratitis: Characterization of Microbial Diversity through Species Richness and Shannon Diversity Index

Author

Schiano-Lomoriello, Domenico, primary, Abicca, Irene, additional, Contento, Laura, additional, Gabrielli, Federico, additional, Alfonsi, Cinzia, additional, Di Pietro, Fabio, additional, Papa, Filomena Tiziana, additional, Ballesteros-Sánchez, Antonio, additional, Sánchez-González, José-María, additional, Rocha-De-Lossada, Carlos, additional, Mazzotta, Cosimo, additional, Giannaccare, Giuseppe, additional, Bonzano, Chiara, additional, and Borroni, Davide, additional

Published
2024
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12. Evaluating GlicoPro Tear Substitute Derived from Helix aspersa Snail Mucus in Alleviating Severe Dry Eye Disease: A First-in-Human Study on Corneal Esthesiometry Recovery and Ocular Pain Relief

Author

Ballesteros-Sánchez, Antonio, primary, Sánchez-González, José-María, additional, Tedesco, Giovanni Roberto, additional, Rocha-de-Lossada, Carlos, additional, Murano, Gianluca, additional, Spinelli, Antonio, additional, Mazzotta, Cosimo, additional, and Borroni, Davide, additional

Published
2024
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17. Dry Eye Para-Inflammation Treatment: Evaluation of a Novel Tear Substitute Containing Hyaluronic Acid and Low-Dose Hydrocortisone

Author

Borroni, Davide, primary, Mazzotta, Cosimo, additional, Rocha-de-Lossada, Carlos, additional, Sánchez-González, José-María, additional, Ballesteros-Sanchez, Antonio, additional, García-Lorente, María, additional, Zamorano-Martín, Francisco, additional, Spinelli, Antonio, additional, Schiano-Lomoriello, Domenico, additional, and Tedesco, Giovanni Roberto, additional

Published
2023
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21. Accelerated Crosslinking Protocols

Author

Mazzotta, Cosimo, Raiskup, Frederik, Baiocchi, Stefano, Scarcelli, Giuliano, Friedman, Marc D., Traversi, Claudio, Mazzotta, Cosimo, Raiskup, Frederik, Baiocchi, Stefano, Scarcelli, Giuliano, Friedman, Marc D., and Traversi, Claudio

Published
2017
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22. Crosslinking Results and Literature Overview

Author

Mazzotta, Cosimo, Raiskup, Frederik, Baiocchi, Stefano, Scarcelli, Giuliano, Friedman, Marc D., Traversi, Claudio, Mazzotta, Cosimo, Raiskup, Frederik, Baiocchi, Stefano, Scarcelli, Giuliano, Friedman, Marc D., and Traversi, Claudio

Published
2017
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23. Crosslinking Evidences In-Vitro and In-Vivo

Author

Mazzotta, Cosimo, Raiskup, Frederik, Baiocchi, Stefano, Scarcelli, Giuliano, Friedman, Marc D., Traversi, Claudio, Mazzotta, Cosimo, Raiskup, Frederik, Baiocchi, Stefano, Scarcelli, Giuliano, Friedman, Marc D., and Traversi, Claudio

Published
2017
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24. Refractive Crosslinking: ACXL Plus

Author

Mazzotta, Cosimo, Raiskup, Frederik, Baiocchi, Stefano, Scarcelli, Giuliano, Friedman, Marc D., Traversi, Claudio, Mazzotta, Cosimo, Raiskup, Frederik, Baiocchi, Stefano, Scarcelli, Giuliano, Friedman, Marc D., and Traversi, Claudio

Published
2017
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27. Ocular Surface Microbiota in Naïve Keratoconus: A Multicenter Validation Study

Author

Rocha-de-Lossada, Carlos, primary, Mazzotta, Cosimo, additional, Gabrielli, Federico, additional, Papa, Filomena Tiziana, additional, Gómez-Huertas, Carmen, additional, García-López, Celia, additional, Urbinati, Facundo, additional, Rachwani-Anil, Rahul, additional, García-Lorente, María, additional, Sánchez-González, José-María, additional, Rechichi, Miguel, additional, Rubegni, Giovanni, additional, and Borroni, Davide, additional

Published
2023
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39. Ocular Surface Microbiota in Naïve Keratoconus: A Multicenter Validation Study

Author

Universidad de Sevilla. Departamento de Física de la Materia Condensada, Rocha de Lossada, Carlos, Mazzotta, Cosimo, Gabrielli, Federico, Papa, Filomena Tiziana, Gómez Huertas, Carmen, García López, Celia, Urbinati, Facundo, Rachwani-Anil, Rahul, García Lorente, María, Sánchez González, José María, Rechichi, Miguel, Rubegni, Giovanni, Borroni, Davide, Universidad de Sevilla. Departamento de Física de la Materia Condensada, Rocha de Lossada, Carlos, Mazzotta, Cosimo, Gabrielli, Federico, Papa, Filomena Tiziana, Gómez Huertas, Carmen, García López, Celia, Urbinati, Facundo, Rachwani-Anil, Rahul, García Lorente, María, Sánchez González, José María, Rechichi, Miguel, Rubegni, Giovanni, and Borroni, Davide

Abstract

In the field of Ophthalmology, the mNGS 16S rRNA sequencing method of studying the microbiota and ocular microbiome is gaining more and more weight in the scientific community. This study aims to characterize the ocular microbiota of patients diagnosed with keratoconus who have not undergone any prior surgical treatment using the mNGS 16S rRNA sequencing method. Samples of naïve keratoconus patients were collected with an eNAT with 1 mL of Liquid Amies Medium (Copan Brescia, Italy), and DNA was extracted and analyzed with 16S NGS. The microbiota analysis showed a relative abundance of microorganisms at the phylum level in each sample collected from 38 patients with KC and 167 healthy controls. A comparison between healthy control and keratoconus samples identified two genera unique to keratoconus, Pelomonas and Ralstonia. Our findings suggest that alterations in the microbiota may play a role in the complex scenario of KC development.

Published
2023

40. Dry Eye Para-Inflammation Treatment: Evaluation of a Novel Tear Substitute Containing Hyaluronic Acid and Low-Dose Hydrocortisone

Author

Universidad de Sevilla. Departamento de Física de la Materia Condensada, Borroni, Davide, Mazzotta, Cosimo, Rocha de Lossada, Carlos, Sánchez González, José María, Ballesteros Sánchez, Antonio, García Lorente, María, Zamorano Martín, Francisco, Spinelli, Antonio, Schiano Lomoriello, Domenico, Tedesco, Giovanni Roberto, Universidad de Sevilla. Departamento de Física de la Materia Condensada, Borroni, Davide, Mazzotta, Cosimo, Rocha de Lossada, Carlos, Sánchez González, José María, Ballesteros Sánchez, Antonio, García Lorente, María, Zamorano Martín, Francisco, Spinelli, Antonio, Schiano Lomoriello, Domenico, and Tedesco, Giovanni Roberto

Abstract

Purpose: The purpose of this study was to check the efficacy and safety of a novel tear substitute containing hyaluronic acid and low-dose hydrocortisone in the treatment of moderate dry eye disease. Methods: In this prospective randomized study, 38 patients with moderate dry eye disease were divided into two treatment groups: Group 1 received one drop of 0.2% sodium hyaluronate and 0.001% hydrocortisone four times daily for 3 months, while Group 2 received 0.15% sodium hyaluronate and 3% trehalose at the same dosage. OSDI and SANDE questionnaires, Non-Invasive Break-Up time (NIBUT), Tear Meniscus Height (TMH), meibography, Lipid Layer Thickness (LLT), Tear Break-Up Time (TBUT), Corneal Staining Score (CFS), and Intraocular Pressure (IOP) were evaluated at baseline and after 1, 2, and 3 months of treatment. Results: During the treatment period, Group 1 showed statistically significant improvement in OSDI score (p = 0.002), SANDE score (p = 0.01), NIBUT (p < 0.0001), LLT (p < 0.0001), TBUT (p = 0.01), and CFS (p = 0.02). In Group 2, significant improvement was observed only in the TBUT score (p < 0.05). Comparison of the two groups showed that NIBUT and LLT were significantly different at the end of treatment (p = 0.001 for both comparisons), with more favorable results for sodium hyaluronate and hydrocortisone than for sodium hyaluronate and trehalose. No significant variations in intraocular pressure were observed in either group during the treatment period (p > 0.05). Conclusions: The study confirms that a 3-months treatment with hyaluronic acid 0.2% in combination with low-dose hydrocortisone 0.001% improves the signs and symptoms of moderate DED and that a low-dosage 0.001% hydrocortisone can be helpful in preventing the progression to chronic stages of DED.

Published
2023

49. The Role of Biomarkers in Keratoconus Pathogenesis and Diagnosis

Author

D'Souza, Sharon, Dickman, Mor, Shetty, Rohit, Armia, Ashraf, Mazzotta, Cosimo, RS: MHeNs - R3 - Neuroscience, Oogheelkunde, and MUMC+: MA UECM Oogartsen MUMC (9)

Abstract

Keratoconus is an inflammatory disease of the cornea associated with corneal thinning, ectasia and biomechanical weakness. It can lead to significant visual disturbance in more advanced cases due to the associated irregular astigmatism and even corneal scarring. The diagnosis of keratoconus is made primarily based on it’s clinical features and corneal topography or tomography. A lot is now known about the multifactorial and polygenic nature of this condition with a variety of risk factors from the environment, inflammation, hormonal imbalance, oxidative stress, genetics, eye rubbing and allergy influencing it. Dysregulated corneal extracellular matrix remodelling is key to keratoconus pathogenesis. Advances in diagnosis and management have helped improve patient care from diagnosis and treatment point of view. However, there are still many lacunae in our understanding of the etiopathogenesis of this disease. Tears have been an important source of biomarkers for keratoconus along with corneal tissue and blood. The increased knowledge about the etiopathogenesis and diagnostic markers has also opened up options for targeted therapies. This chapter discusses the various biomarkers of keratoconus which are available to us and their role in understanding disease pathogenesis, diagnosis and treatment.

Published
2022

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