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1. Oligometastatic sarcoma treated with Curative intent Ablative Radiotherapy (OSCAR): A multicenter study on behalf of AIRO (Italian association of Radiotherapy and clinical Oncology)

Author

Franceschini, D., Greto, D., Dicuonzo, S., Navarria, F., Federico, M., La Vecchia, M., Sangalli, C., Allajbej, A., Di Cristina, L., Mazzola, R., Pontoriero, A., Montesi, G., Navarria, P., Baldaccini, D., Clerici, E., Lo Faro, L., Franzese, C., Di Biase, S., Pergolizzi, S., Alongi, F., Bignardi, M., Fazio, I., Mascarin, M., Jereczek-Fossa, B.A., Livi, L., and Scorsetti, M.

Published
2024
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2. Hypofractionated Postoperative Radiotherapy in Prostate Cancer with Ialuril Soft Gels®: Toxicity and Efficacy Analysis on a Retrospective Series of 305 Patients

Author

Nicosia L, Vitale C, Cuccia F, Figlia V, Giaj-Levra N, Mazzola R, Ricchetti F, Rigo M, Ruggieri R, Cavalleri S, and Alongi F

Subjects
prostate cancer, hyaluronic acid, postoperative radiotherapy, salvage radiotherapy, hypofractionation, toxicity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Luca Nicosia,1 Claudio Vitale,1 Francesco Cuccia,1 Vanessa Figlia,1 Niccolò Giaj-Levra,1 Rosario Mazzola,1 Francesco Ricchetti,1 Michele Rigo,1 Ruggero Ruggieri,1 Stefano Cavalleri,2 Filippo Alongi1,3 1Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Cancer Care Center, Verona, Negrar, Italy; 2Urology Division, IRCCS Sacro Cuore Don Calabria Hospital, Verona, Negrar, Italy; 3University of Brescia, Brescia, ItalyCorrespondence: Luca Nicosia, Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Cancer Care Center, via Don Sempreboni 5, 37034, Verona, Negrar, Italy, Tel +39 045-6014800, Fax +045-60148071, Email lucanicosia.rg@gmail.comAim: To evaluate the impact of Ialuril soft Gels® (HA) in reducing acute genito-urinary (GU) toxicity in patients treated with adjuvant or salvage radiotherapy for a prostate cancer relapse.Material and Methods: The data of 305 patients were retrospectively collected. One hundred and five patients underwent adjuvant radiotherapy (aRT), while 200 a salvage treatment (sRT). GU toxicity was evaluated according to CTCAE v5.0. Every patient received RT combined with HA.Results: Grade 1– 2 GU toxicity during RT was represented by: urgency (36%), dysuria (23%), increased urinary frequency (12.1%), and urinary retention (11.8%). Nevertheless, the majority of symptoms were present at the baseline. Grade 3 severe toxicity was represented by 10 (3.2%) cases of incontinence and 3 (1%) cases of urgency. The incidence of any-grade RT-related GU toxicity was significantly higher in the aRT group than the salvage group (esRT + sRT) (83.8% versus 64.5%). When comparing the incidence of any-grade RT-related GU toxicity in the aRT, esRT, and sRT groups we observed a significant correlation favoring sRT, over esRT, and aRT.Conclusion: Postoperative hypofractionated radiotherapy is safe and not correlated with increase of unexpected toxicity when administered with oral hyaluronic acid. A prospective study is necessary to confirm these results.Keywords: prostate cancer, hyaluronic acid, postoperative radiotherapy, salvage radiotherapy, hypofractionation, toxicity

Published
2022

3. Pattern of Recurrence After Stereotactic Radiotherapy in Prostate Cancer Patients With Nodal Pelvic Relapse. A Multi-Institutional Retrospective Analysis

Author

Francolini, G., Bellini, C., Di Cataldo, V., Detti, B., Bruni, A., Alicino, G., Triggiani, L., La Mattina, S., D'Angelillo, R.M., Demofonti, C., Mazzola, R., Cuccia, F., Alongi, F., Aquilano, M., Allegra, A.G., Ciccone, L.P., Burchini, L., Salvestrini, V., Morelli, I., Frosini, G., Desideri, I., and Livi, L.

Published
2022
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5. Prostate re-irradiation after previous definitive or salvage radiotherapy (RE-START). A study on behalf of Italian Association of Radiotherapy and Clinical Oncology (AIRO)

Author

Francolini, G., primary, Matrone, F., additional, Donofrio, A., additional, Marvaso, G., additional, Jereczek-Fossa, B.A., additional, Belgioia, L., additional, D’angelo, E., additional, Mazzola, R., additional, Ingargiola, R., additional, Fontana, A., additional, Cacciola, A., additional, Scipilliti, E., additional, Miszczyk, M., additional, Di Cataldo, V., additional, and Livi, L., additional

Published
2024
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14. A multicenter LArge retrospectIve daTabase on the personalization of stereotactic ABlative radiotherapy use in lung metastases from colon-rectal cancer: The LaIT-SABR study

Author

Nicosia, L, Franceschini, D, Perrone-Congedi, F, Casamassima, F, Gerardi, M, Rigo, M, Mazzola, R, Perna, M, Scotti, V, Fodor, A, Iurato, A, Pasqualetti, F, Gadducci, G, Chiesa, S, Niespolo, R, Bruni, A, Alicino, G, Frassinelli, L, Borghetti, P, Di Marzo, A, Ravasio, A, De Bari, B, Sepulcri, M, Aiello, D, Mortellaro, G, Sangalli, C, Franceschini, M, Montesi, G, Aquilanti, F, Lunardi, G, Valdagni, R, Fazio, I, Scarzello, G, Corti, L, Vavassori, V, Maranzano, E, Magrini, S, Arcangeli, S, Gambacorta, M, Valentini, V, Paiar, F, Ramella, S, Di Muzio, N, Livi, L, Jereczek-Fossa, B, Osti, M, Scorsetti, M, Alongi, F, Nicosia L., Franceschini D., Perrone-Congedi F., Casamassima F., Gerardi M. A., Rigo M., Mazzola R., Perna M., Scotti V., Fodor A., Iurato A., Pasqualetti F., Gadducci G., Chiesa S., Niespolo R. M., Bruni A., Alicino G., Frassinelli L., Borghetti P., Di Marzo A., Ravasio A., De Bari B., Sepulcri M., Aiello D., Mortellaro G., Sangalli C., Franceschini M., Montesi G., Aquilanti F. M., Lunardi G., Valdagni R., Fazio I., Scarzello G., Corti L., Vavassori V., Maranzano E., Magrini S. M., Arcangeli S., Gambacorta M. A., Valentini V., Paiar F., Ramella S., Di Muzio N. G., Livi L., Jereczek-Fossa B. A., Osti M. F., Scorsetti M., Alongi F., Nicosia, L, Franceschini, D, Perrone-Congedi, F, Casamassima, F, Gerardi, M, Rigo, M, Mazzola, R, Perna, M, Scotti, V, Fodor, A, Iurato, A, Pasqualetti, F, Gadducci, G, Chiesa, S, Niespolo, R, Bruni, A, Alicino, G, Frassinelli, L, Borghetti, P, Di Marzo, A, Ravasio, A, De Bari, B, Sepulcri, M, Aiello, D, Mortellaro, G, Sangalli, C, Franceschini, M, Montesi, G, Aquilanti, F, Lunardi, G, Valdagni, R, Fazio, I, Scarzello, G, Corti, L, Vavassori, V, Maranzano, E, Magrini, S, Arcangeli, S, Gambacorta, M, Valentini, V, Paiar, F, Ramella, S, Di Muzio, N, Livi, L, Jereczek-Fossa, B, Osti, M, Scorsetti, M, Alongi, F, Nicosia L., Franceschini D., Perrone-Congedi F., Casamassima F., Gerardi M. A., Rigo M., Mazzola R., Perna M., Scotti V., Fodor A., Iurato A., Pasqualetti F., Gadducci G., Chiesa S., Niespolo R. M., Bruni A., Alicino G., Frassinelli L., Borghetti P., Di Marzo A., Ravasio A., De Bari B., Sepulcri M., Aiello D., Mortellaro G., Sangalli C., Franceschini M., Montesi G., Aquilanti F. M., Lunardi G., Valdagni R., Fazio I., Scarzello G., Corti L., Vavassori V., Maranzano E., Magrini S. M., Arcangeli S., Gambacorta M. A., Valentini V., Paiar F., Ramella S., Di Muzio N. G., Livi L., Jereczek-Fossa B. A., Osti M. F., Scorsetti M., and Alongi F.

Abstract

Introduction: Stereotactic ablative radiotherapy (SABR) has been shown to increase survival in oligometastatic disease, but local control of colorectal metastases remains poor. We aimed to identify potential predictive factors of SBRT response through a multicenter large retrospective database and to investigate the progression to the polymetastatic disease (PMD). Material and methods: The study involved 23 centers, and was approved by the Ethical Committee (Prot. Negrar 2019-ZT). 1033 lung metastases were reported. Clinical and biological parameters were evaluated as predictive for freedom from local progression-free survival (FLP). Secondary end-point was the time to the polymetastatic conversion (tPMC). Results: Two-year FLP was 75.4%. Two-year FLP for lesions treated with a BED < 00 Gy, 100–124 Gy, and ≥125 Gy was 76.1%, 70.6%, and 94% (p = 0.000). Two-year FLP for lesion measuring ≤10 mm, 10–20 mm, and >20 mm was 79.7%, 77.1%, and 66.6% (p = 0.027). At the multivariate analysis a BED ≥125 Gy significantly reduced the risk of local progression (HR 0.24, 95%CI 0.11–0.51; p = 0.000). Median tPMC was 26.8 months. Lesions treated with BED ≥125 Gy reported a significantly longer tPMC as compared to lower BED. The median tPMC for patients treated to 1, 2–3 or 4–5 simultaneous oligometastases was 28.5, 25.4, and 9.8 months (p = 0.035). Conclusion: The present is the largest series of lung colorectal metastases treated with SABR. The results support the use of SBRT in lung oligometastatic colorectal cancer patients as it might delay the transition to PMD or offer relatively long disease-free period in selected cases. Predictive factors were identified for treatment personalization.

Published
2022

16. Toxicity patterns and preliminary clinical outcomes of 1.5T MR-guided stereotactic body radiotherapy for prostate cancer

Author

Cuccia, F., primary, Figlia, V., additional, Rigo, M., additional, Mazzola, R., additional, Giaj Levra, N., additional, Nicosia, L., additional, Ricchetti, F., additional, Trapani, G., additional, Attinà, G., additional, Pastorello, E., additional, Vitale, C., additional, Ruggieri, R., additional, and Alongi, F., additional

Published
2022
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20. A Multicenter Large Retrospective Database on the Personalization of Stereotactic Ablative Radiotherapy for Lung Metastases From Colon-Rectal Cancer: The LaIT-SABR Study

Author

Nicosia, L, Franceschini, D, Perrone, F, Casamassima, F, Gerardi, M, Perna, M, Scotti, V, Fodor, A, Mazzola, R, Rigo, M, Iurato, A, Pasqualetti, F, Chiesa, S, Niespolo, R, Bruni, A, Frassinelli, L, Borghetti, P, Marzo, A, Ravasio, A, De Bari, B, Sepulcri, M, Aiello, D, Mortellaro, G, Sangalli, C, Franceschini, M, Montesi, G, Aquilanti, F, Valdagni, R, Fazio, I, Corti, L, Vavassori, L, Maranzano, E, Magrini, S, Lohr, F, Arcangeli, S, Valentini, V, Paiar, F, Ramella, S, Di Muzio, N, Livi, L, Jereczek-Fossa, B, Osti, M, Scorsetti, M, Alongi, F, Nicosia L., Franceschini D., Perrone F., Casamassima F., Gerardi M. A., Perna M., Scotti V., Fodor A., Mazzola R., Rigo M., Iurato A., Pasqualetti F., Chiesa S., Niespolo R. M., Bruni A., Frassinelli L., Borghetti P., Marzo A. D., Ravasio A., De Bari B., Sepulcri M., Aiello D., Mortellaro G., Sangalli C., Franceschini M., Montesi G., Aquilanti F. M., Valdagni R., Fazio I., Corti L., Vavassori L., Maranzano E., Magrini S., Lohr F., Arcangeli S., Valentini V., Paiar F., Ramella S., Di Muzio N. G., Livi L., Jereczek-Fossa B. A., Osti M. F., Scorsetti M., Alongi F., Nicosia, L, Franceschini, D, Perrone, F, Casamassima, F, Gerardi, M, Perna, M, Scotti, V, Fodor, A, Mazzola, R, Rigo, M, Iurato, A, Pasqualetti, F, Chiesa, S, Niespolo, R, Bruni, A, Frassinelli, L, Borghetti, P, Marzo, A, Ravasio, A, De Bari, B, Sepulcri, M, Aiello, D, Mortellaro, G, Sangalli, C, Franceschini, M, Montesi, G, Aquilanti, F, Valdagni, R, Fazio, I, Corti, L, Vavassori, L, Maranzano, E, Magrini, S, Lohr, F, Arcangeli, S, Valentini, V, Paiar, F, Ramella, S, Di Muzio, N, Livi, L, Jereczek-Fossa, B, Osti, M, Scorsetti, M, Alongi, F, Nicosia L., Franceschini D., Perrone F., Casamassima F., Gerardi M. A., Perna M., Scotti V., Fodor A., Mazzola R., Rigo M., Iurato A., Pasqualetti F., Chiesa S., Niespolo R. M., Bruni A., Frassinelli L., Borghetti P., Marzo A. D., Ravasio A., De Bari B., Sepulcri M., Aiello D., Mortellaro G., Sangalli C., Franceschini M., Montesi G., Aquilanti F. M., Valdagni R., Fazio I., Corti L., Vavassori L., Maranzano E., Magrini S., Lohr F., Arcangeli S., Valentini V., Paiar F., Ramella S., Di Muzio N. G., Livi L., Jereczek-Fossa B. A., Osti M. F., Scorsetti M., and Alongi F.

Abstract

PURPOSE/OBJECTIVE(S): stereotactic ablative radiotherapy (SABR) has been shown to increase survival rates in oligometastatic disease (OMD), but local control of colorectal metastases still remains poor. We aimed to identify potential predictive factors of SBRT response through a multicenter large retrospective database and to investigate how lung SBRT can impact on the progression to the polymetastatic disease (PMD). MATERIALS/METHODS: the study involved 22 centers, and was approved by the Ethical Committee (Prot. Negrar 2019-ZT). 1023 lung metastases treated with SBRT in 622 patients were reported. The median BED was 105 Gy10. Lesion diameter GTV, PTV volume, dose, fractionations, and site of primary tumor were evaluated as potential predictive marker for SBRT response for the primary end-point local progression-free survival (LPFS). EGFR, KRAS, NRAS, BRAF, and MSI were also evaluated. Secondary end-point was the time to the polymetastatic conversion (ttPMC). RESULTS: the median follow-up was 26 months (range 3-117 months). The median lesion diameter was 13 mm (range 4-58 mm). The 2- and 3-year LPFS were 75.6% and 71%, respectively. At the univariate analysis, BED ≥125Gy10 was associated with improved LPFS (2-year: 94.1% versus 72.6%; P = < 0.0001), single fraction SBRT correlated with better LPFS in the overall population (2-year: 80.6% versus 73.7%; P = 0.03), but no significant difference was observed when considering the population treated with BED > 100 Gy10. Lesion diameter ≤19 mm correlated with improved LPFS (2-year 80% versus 60%; P = < 0.0001). The median ttPMC was 26 months, and the 2-year ttPMC was 54.5%. The median PFS was 11.3 months. After SABR, 36% patients had polymetastatic relapse, 39.5% patients had an oligometastatic relapse, and 24.5% patients had no further relapse. CONCLUSION: the present is the largest series of lung colorectal metastases treated with SABR. The results support the use of SBRT in lung oligometastatic colorectal canc

Published
2021

22. Cachexia induces head and neck changes in locally advanced oropharyngeal carcinoma during definitive cisplatin and image-guided volumetric-modulated arc radiation therapy

Author

Mazzola, R., Ricchetti, F., Florentino, A., Di Paola, G., Fersino, S., Levra, N. Giaj, Ruggieri, R., and Alongi, F.

Subjects
Cisplatin -- Health aspects, Radiotherapy -- Methods, Cachexia -- Care and treatment, Head and neck cancer -- Care and treatment, Food/cooking/nutrition, Health
Abstract

BACKGROUND/OBJECTIVES: Cancer cachexia is a syndrome characterized by weight loss (WL) and sarcopenia. Aim of the study was to assess the impact of cachexia on head and neck changes during definitive cisplatin and image-guided volumetric- modulated arc radiation therapy in a series of locally advanced oropharyngeal cancer. SUBJECTS/METHODS: Volume variations of sternocleidomastoid muscle (SCM) were considered as surrogate of muscle changes related to sarcopenia. Two head and neck diameters, encompassing the cranial limits of II and III nodal levels (defined as 'head diameter' and 'neck diameter', respectively), were measured. All parameters were defined retrospectively by means of on-board cone beam computed tomography images at 1-8th to 15-22th and at last fraction (fx) of radiotherapy (RT). Cachexia was defined as WL >5% during treatment. Analysis was conducted correlating the parameter changes with three WL ranges: < 5, 5-9 and > 10%. RESULTS: Thirty patients were evaluated. One hundred and fifty contoured SCMs and three hundred diameters were collected. Median WL was 6.5% (range, 0-16%). The most significant SCM shrinkage was recorded at 15th fx (mean 1.6 cc) related to WL 5-9% and WL > 10% (P 0.001). For 'head diameter', the peak reduction was recorded at the 15th fx (mean 8 mm), statistically correlated to WL > 10% (P 0.001). The peak reduction in 'neck diameter' was registered at the 22th fx (mean 6 mm), with a gradual reduction until the end of treatment for WL >5%. CONCLUSIONS: In a homogeneous cohort of patients, present study quantified the impact of cachexia on head and neck changes. Present data could provide adaptive RT implications for further investigations. European Journal of Clinical Nutrition (2016) 70, 738-742;doi:10.1038/ejcn.2016.61; published online 13 April 2016, INTRODUCTION In definitive chemo-radiotherapy (chemo-RT) for head and neck cancer (HNC), patient weight loss (WL) has shown detrimental effects on quality of life, performance status and compliance to treatment. (1) [...]

Published
2016
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24. 'Vecchie' questioni e nuovi strumenti: il crocifisso scolastico e il diritto antidiscriminatorio

Author

Ragone, G, Vanoni, LP, Anrò, I, Croci, F, Ceff, CB, Giannuzzo, L, Scala, G, Cesarini, A, Colombo, F, Losanno, A, Spadaro, I, Ferrari, D, Galluccio, A, Mazzola, R, Pagotto, T, Testa Bappenheim, S, Tira, A, Attollino, S, Ciravegna, M, Geraci, S, Losurdo, R, Marcaccio, G, Negri, A, Suffia, G, Baldassarre, S, Ferrara, F, Ferraro, F, Oliosi, F, Toscano, M, Ragone, G, Vanoni, LP, Anrò, I, Croci, F, Ceff, CB, Giannuzzo, L, Scala, G, Cesarini, A, Colombo, F, Losanno, A, Spadaro, I, Ferrari, D, Galluccio, A, Mazzola, R, Pagotto, T, Testa Bappenheim, S, Tira, A, Attollino, S, Ciravegna, M, Geraci, S, Losurdo, R, Marcaccio, G, Negri, A, Suffia, G, Baldassarre, S, Ferrara, F, Ferraro, F, Oliosi, F, and Toscano, M

Published
2022

25. Hans Kelsen’s Philosophy of Revenge

Author

Terradas Saborit, I, Di Lucia, P, Passerini Glazel, L, Tuori, K, Fittipaldi, E, Mazzola, R, Lorini, G, Loddo, OG, Doñate Sastre, M, Rosés Tubau, M, Romero Noguera, P, Ortuño Aix, JM, Alonso Cabré, M, de Menech, C, Remotti, G, Nicolini Coen, C, Mamoulaki, E, Márquez Porras, R, Bofill-Poch, S, Montesinos, L, Bullen, M, Di Lucia, Paolo, Passerini Glazel, Lorenzo, Terradas Saborit, I, Di Lucia, P, Passerini Glazel, L, Tuori, K, Fittipaldi, E, Mazzola, R, Lorini, G, Loddo, OG, Doñate Sastre, M, Rosés Tubau, M, Romero Noguera, P, Ortuño Aix, JM, Alonso Cabré, M, de Menech, C, Remotti, G, Nicolini Coen, C, Mamoulaki, E, Márquez Porras, R, Bofill-Poch, S, Montesinos, L, Bullen, M, Di Lucia, Paolo, and Passerini Glazel, Lorenzo

Abstract

Hans Kelsen devoted significant attention to “primitive” law, particularly to the phenomenon of blood revenge. His analysis of blood revenge bears witness to the intent to offer a general theory of law, in all its different manifestations. Such a theory, far from being restricted to the centralized legal systems of modern states, also accounts for more decentralized legal systems, including those of “primitive,” stateless societies and international law. The present chapter develops both an analysis of Kelsen’s sociological and anthropological works on revenge and an examination of the role that revenge played in his famous pure theory of law.

Published
2022

26. PD-0250 Therapeutic use of Linac-based SRS in malignant spasticity: early results from a prospective trial

Author

Nicosia, L., primary, Avesani, R., additional, Rossato, E., additional, Ferrari, F., additional, Cuccia, F., additional, Figlia, V., additional, Giaj-Levra, N., additional, Mazzola, R., additional, Ricchetti, F., additional, Rigo, M., additional, Attinà, G., additional, Vitale, C., additional, Marchioretto, F., additional, Zamperini, M., additional, De Simone, A., additional, Ruggeri, R., additional, and Alongi, F., additional

Published
2022
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27. PO-1452 Stereotactic ablative radiotherapy in patients with refractory ventricular tachyarrhythmia

Author

Nicosia, L., primary, Giaj-Levra, N., additional, Sicignano, G., additional, Cuccia, F., additional, Figlia, V., additional, Mazzola, R., additional, Ricchetti, F., additional, Rigo, M., additional, Vitale, C., additional, Attinà, G., additional, De Simone, A., additional, Gurrera, D., additional, Ruggeri, R., additional, Molon, G., additional, and Alongi, F., additional

Published
2022
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29. OC-0602 A pREDictive model of polymetastatic disease on oligometastatic colorectal cancer: the RED LaIT-SABR

Author

Nicosia, L., primary, Franceschini, D., additional, Perrone Congedi, F., additional, Casamassima, F., additional, Gerardi, M.A., additional, Rigo, M., additional, Mazzola, R., additional, Perna, M., additional, Scotti, V., additional, Fodor, A., additional, Iurato, A., additional, Pasqualetti, F., additional, Gadducci, G., additional, Chiesa, S., additional, Niespolo, R.M., additional, Bruni, A., additional, Alicino, G., additional, Frassinelli, L., additional, Borghetti, P., additional, Di Marzo, A., additional, Ravasio, A., additional, De Bari, B., additional, Sepulcri, M., additional, Aiello, D., additional, Mortellaro, G., additional, Sangalli, C., additional, Franceschini, M., additional, Montesi, G., additional, Aquilanti, F.M., additional, Lunardi, G., additional, Valdagni, R., additional, Fazio, I., additional, Corti, L., additional, Vavassori, V., additional, Maranzano, E., additional, Magrini, S.M., additional, Arcangeli, S., additional, Valentini, V., additional, Paiar, F., additional, Ramella, S., additional, Di Muzio, N.G., additional, Livi, L., additional, Jereczek- Fossa, B.A., additional, Osti, M.F., additional, Scorsetti, M., additional, and Alongi, F., additional

Published
2022
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30. PD-0086 PSMA-PET guided stereotactic body radiotherapy for bone oligorecurrent prostate cancer

Author

Cuccia, F., primary, Mazzola, R., additional, Pastorello, E., additional, Ingrosso, G., additional, Franzese, C., additional, Scorsetti, M., additional, Figlia, V., additional, Giaj-Levra, N., additional, Nicosia, L., additional, Rigo, M., additional, Ricchetti, F., additional, Vitale, C., additional, Attinà, G., additional, Ruggieri, R., additional, and Alongi, F., additional

Published
2022
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35. Association Between Objectively-Measured Lung Function and Sleep Disorder Symptoms in a Community-Based Multi-Site Cohort Study

Author

Mazzola, R., primary, Aaron, S., additional, Vandemheen, K., additional, Chin, M., additional, Mulpuru, S., additional, FitzGerald, J.M., additional, Bergeron, C., additional, Lemière, C., additional, Boulet, L.-P., additional, Field, S.K., additional, Penz, E., additional, McIvor, R.A., additional, Gupta, S., additional, Mayers, I., additional, Bhutani, M., additional, Hernandez, P., additional, Lougheed, M.D., additional, Licskai, C.J., additional, Azher, T., additional, Ainslie, M., additional, Fraser, I., additional, Mahdavian, M., additional, and Kendzerska, T., additional

Published
2022
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36. PD-0575 Toxicity and QoL report of 1.5T MR-guided SBRT for prostate cancer in the first 100 patients

Author

Cuccia, F., primary, Figlia, V., additional, Rigo, M., additional, Nicosia, L., additional, Mazzola, R., additional, Giaj-Levra, N., additional, Ricchetti, F., additional, Attinà, G., additional, Pastorello, E., additional, Vitale, C., additional, De Simone, A., additional, Gurrera, D., additional, Naccarato, S., additional, Sicignano, G., additional, Ruggieri, R., additional, and Alongi, F., additional

Published
2022
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39. A multicenter LArge retrospectIve daTabase on the personalization of stereotactic ABlative radiotherapy use in lung metastases from colon-rectal cancer: The LaIT-SABR study

Author

Nicosia, L., primary, Franceschini, D., additional, Perrone-Congedi, F., additional, Casamassima, F., additional, Gerardi, M.A., additional, Rigo, M., additional, Mazzola, R., additional, Perna, M., additional, Scotti, V., additional, Fodor, A., additional, Iurato, A., additional, Pasqualetti, F., additional, Gadducci, G., additional, Chiesa, S., additional, Niespolo, R.M., additional, Bruni, A., additional, Alicino, G., additional, Frassinelli, L., additional, Borghetti, P., additional, Di Marzo, A., additional, Ravasio, A., additional, De Bari, B., additional, Sepulcri, M., additional, Aiello, D., additional, Mortellaro, G., additional, Sangalli, C., additional, Franceschini, M., additional, Montesi, G., additional, Aquilanti, F.M., additional, Lunardi, G., additional, Valdagni, R., additional, Fazio, I., additional, Scarzello, Giovanni, additional, Corti, L., additional, Vavassori, V., additional, Maranzano, E., additional, Magrini, S.M., additional, Arcangeli, S., additional, Gambacorta, Maria Antonietta, additional, Valentini, V., additional, Paiar, F., additional, Ramella, S., additional, Di Muzio, N.G., additional, Livi, L., additional, Jereczek-Fossa, B.A., additional, Osti, M.F., additional, Scorsetti, M., additional, and Alongi, F., additional

Published
2022
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40. PSMA-guided SBRT for bone oligometastatic prostate cancer: a monoinstitutional report of preliminary outcomes and toxicity

Author

Cuccia, F., primary, Mazzola, R., additional, Pastorello, E., additional, Rigo, M., additional, Giaj-Levra, N., additional, Nicosia, L., additional, Figlia, V., additional, Ricchetti, F., additional, Attinà, G., additional, Vitale, C., additional, De Simone, A., additional, Gurrera, D., additional, Naccarato, S., additional, Sicignano, G., additional, Ruggieri, R., additional, and Alongi, F., additional

Published
2021
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41. Preliminary Dosimetric Analysis of the First 150 Sessions of 1.5-T MR-Guided Daily-Adaptive Radiotherapy for Abdomino-Pelvic Lymph-Nodal Oligometastases

Author

Cuccia, F., primary, Rigo, M., additional, Gurrera, D., additional, Nicosia, L., additional, Figlia, V., additional, Giaj-Levra, N., additional, Mazzola, R., additional, Ricchetti, F., additional, Attinà, G., additional, De Simone, A., additional, Naccarato, S., additional, Sicignano, G., additional, Ruggieri, R., additional, and Alongi, F., additional

Published
2021
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42. Preliminary report of toxicity and quality of life of the first 100 patients treated with 1.5T MR-guided stereotactic body radiotherapy for prostate cancer

Author

Cuccia, F., primary, Figlia, V., additional, Rigo, M., additional, Nicosia, L., additional, Mazzola, R., additional, Giaj-Levra, N., additional, Ricchetti, F., additional, Attinà, G., additional, Pastorello, E., additional, De Simone, A., additional, Gurrera, D., additional, Naccarato, S., additional, Sicignano, G., additional, Ruggieri, R., additional, and Alongi, F., additional

Published
2021
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43. Impact of hydrogel peri-rectal spacer insertion on seminal vesicles intra-fraction motion during 1.5 t-MRI-guided adaptive stereotactic body radiotherapy for localized prostate cancer

Author

Cuccia, F., primary, Mazzola, R., additional, Sicignano, G., additional, Vitale, C., additional, Rigo, M., additional, Giaj-Levra, N., additional, Nicosia, L., additional, Figlia, V., additional, Ricchetti, F., additional, Attinà, G., additional, Pastorello, E., additional, De Simone, A., additional, Gurrera, D., additional, Naccarato, S., additional, Ruggieri, R., additional, and Alongi, F., additional

Published
2021
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44. A Multicenter Large Retrospective Database on the Personalization of Stereotactic Ablative Radiotherapy for Lung Metastases From Colon-Rectal Cancer: The LaIT-SABR Study

Author

Nicosia, L., primary, Franceschini, D., additional, Perrone, F., additional, Casamassima, F., additional, Gerardi, M.A., additional, Perna, M., additional, Scotti, V., additional, Fodor, A., additional, Mazzola, R., additional, Rigo, M., additional, Iurato, A., additional, Pasqualetti, F., additional, Chiesa, S., additional, Niespolo, R.M., additional, Bruni, A., additional, Frassinelli, L., additional, Borghetti, P., additional, Marzo, A. Di, additional, Ravasio, A., additional, De Bari, B., additional, Sepulcri, M., additional, Aiello, D., additional, Mortellaro, G., additional, Sangalli, C., additional, Franceschini, M., additional, Montesi, G., additional, Aquilanti, F.M., additional, Valdagni, R., additional, Fazio, I., additional, Corti, L., additional, Vavassori, L., additional, Maranzano, E., additional, Magrini, S., additional, Lohr, F., additional, Arcangeli, S., additional, Valentini, V., additional, Paiar, F., additional, Ramella, S., additional, Di Muzio, N.G., additional, Livi, L., additional, Jereczek-Fossa, B.A., additional, Osti, M.F., additional, Scorsetti, M., additional, and Alongi, F., additional

Published
2021
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45. Stereotactic radiotherapy for oligometastases in the lymph nodes

Author

Pasqualetti, F., Trippa, F., Aristei, C., Borghesi, S., Colosimo, C., Cantarella, M., Mazzola, R., and Ingrosso, G.

Subjects
Oligometastasis, Toxicity, Oncology, Local control, Stereotactic radiotherapy, Hypofractionation, Radiology, Nuclear Medicine and imaging, Bed, Organ motion, Radiosurgery, Lymph node metastases
Abstract

Even though systemic therapy is standard treatment for lymph node metastases, metastasis-directed stereotactic radiotherapy (SRT ) seems to be a valid option in oligometastatic patients with a low disease burden. Positron emission tomography-computed tomography (PET-CT ) is the gold standard for assessing metastases to the lymph nodes; co-registration of PET-CT images and planning CT images are the basis for gross tumor volume (GTV ) delineation. Appropriate techniques are needed to overcome target motion. SRT schedules depend on the irradiation site, target volume and dose constraints to the organs at risk (OARs) of toxicity. Although several fractionation schemes were reported, total doses of 48-60 Gy in 4-8 fractions were proposed for mediastinal lymph node SRT, with the spinal cord, esophagus, heart and proximal bronchial tree being the dose limiting OAR s. Total doses ranged from 30 to 45 Gy, with daily fractions of 7-12 Gy for abdominal lymph nodes, with dose limiting OARs being the liver, kidneys, bowel and bladder. SRT on lymph node metastases is safe; late side effects, particularly severe, are rare.

Published
2021

46. Il pentimento come atto giuridico

Author

Mazzola, R.

Subjects
Adolf Reinach, Criminal Law, Repentance, Restorative Justice, Social Acts, Settore IUS/20 - Filosofia del Diritto
Published
2021

48. PH-0112 Multicenter large retrospectIve database on SBRT for colorectal lung metastases: the LaIT-SABR study

Author

Nicosia, L., primary, Franceschini, D., additional, Perrone Congedi, F., additional, Casamassima, F., additional, Gerardi, M.A., additional, Perna, M., additional, Scotti, V., additional, Fodor, A., additional, Mazzola, R., additional, Rigo, M., additional, Iurato, A., additional, Pasqualetti, F., additional, Gadducci, G., additional, Chiesa, S., additional, Niespolo, R.M., additional, Bruni, A., additional, Frassinelli, L., additional, Borghetti, P., additional, Di Marzo, A., additional, Ravasio, A., additional, De Bari, B., additional, Sepulcri, M., additional, Aiello, D., additional, Mortellaro, G., additional, Sangalli, C., additional, Franceschini, M., additional, Montesi, G., additional, Aquilanti, F.M., additional, Valdagni, R., additional, Fazio, I., additional, Corti, L., additional, Vavassori, L., additional, Maranzano, E., additional, Magrini, S.M., additional, Lohr, F., additional, Arcangeli, S., additional, Valentini, V., additional, Paiar, F., additional, Ramella, S., additional, Di Muzio, N.G., additional, Livi, L., additional, Jereczek-Fossa, B.A., additional, Osti, M.F., additional, Scorsetti, M., additional, and Alongi, F., additional

Published
2021
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49. PO-1366 Pattern of recurrence after SBRT in prostate cancer patients with nodal pelvic relapse

Author

Francolini, G., primary, Bellini, C., additional, Di Cataldo, V., additional, Detti, B., additional, Bruni, A., additional, Alicino, G., additional, Triggiani, L., additional, La Mattina, S., additional, D’Angelillo, R.M., additional, Demofonti, C., additional, Mazzola, R., additional, Cuccia, F., additional, Alongi, F., additional, Aquilano, M., additional, Allegra, A.G., additional, Ciccone, L.P., additional, Stocchi, G., additional, Salvestrini, V., additional, Guerrieri, B., additional, and Livi, L., additional

Published
2021
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50. PO-1439 Clinical results of SBRT for spinal metastases using dedicated contouring/planning system

Author

Figlia, V., primary, Giaj-Levra, N., additional, Mazzola, R., additional, Rigo, M., additional, Cuccia, F., additional, Nicosia, L., additional, Ricchetti, F., additional, Attinà, G., additional, Pastorello, E., additional, Sicignano, G., additional, De Simone, A., additional, Naccarato, S., additional, Gurrera, D., additional, Ruggieri, R., additional, and Alongi, F., additional

Published
2021
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