Search

Your search keyword '"Mazza, Davide"' showing total 333 results
Start Over Author "Mazza, Davide"
333 results on '"Mazza, Davide"'

3. Acetylation reprograms MITF target selectivity and residence time

Author

Louphrasitthiphol, Pakavarin, Loffreda, Alessia, Pogenberg, Vivian, Picaud, Sarah, Schepsky, Alexander, Friedrichsen, Hans, Zeng, Zhiqiang, Lashgari, Anahita, Thomas, Benjamin, Patton, E. Elizabeth, Wilmanns, Matthias, Filippakopoulos, Panagis, Lambert, Jean-Philippe, Steingrímsson, Eiríkur, Mazza, Davide, and Goding, Colin R.

Published
2023
Full Text
View/download PDF

5. Pathogenic variants in the AFG3L2 proteolytic domain cause SCA28 through haploinsufficiency and proteostatic stress-driven OMA1 activation

Author

Tulli, Susanna, Del Bondio, Andrea, Baderna, Valentina, Mazza, Davide, Codazzi, Franca, Pierson, Tyler Mark, Ambrosi, Alessandro, Nolte, Dagmar, Goizet, Cyril, Toro, Camilo, Baets, Jonathan, Deconinck, Tine, DeJonghe, Peter, Mandich, Paola, Casari, Giorgio, and Maltecca, Francesca

Subjects
Biochemistry and Cell Biology, Biological Sciences, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, ATP-Dependent Proteases, ATPases Associated with Diverse Cellular Activities, Animals, Calcium, Fibroblasts, Genetic Variation, HEK293 Cells, Haploinsufficiency, Humans, Metalloendopeptidases, Mice, Mice, Knockout, Mitochondria, Models, Biological, Protein Binding, Protein Domains, Protein Multimerization, Proteolysis, Proteostasis, Stress, Physiological, Transcriptional Activation, genetics, molecular genetics, movement disorders, mitochondria, cell biology, Medical and Health Sciences, Genetics & Heredity, Genetics, Clinical sciences
Abstract

BACKGROUND:Spinocerebellar ataxia type 28 (SCA28) is a dominantly inherited neurodegenerative disease caused by pathogenic variants in AFG3L2. The AFG3L2 protein is a subunit of mitochondrial m-AAA complexes involved in protein quality control. Objective of this study was to determine the molecular mechanisms of SCA28, which has eluded characterisation to date. METHODS:We derived SCA28 patient fibroblasts carrying different pathogenic variants in the AFG3L2 proteolytic domain (missense: the newly identified p.F664S and p.M666T, p.G671R, p.Y689H and a truncating frameshift p.L556fs) and analysed multiple aspects of mitochondrial physiology. As reference of residual m-AAA activity, we included SPAX5 patient fibroblasts with homozygous p.Y616C pathogenic variant, AFG3L2+/- HEK293 T cells by CRISPR/Cas9-genome editing and Afg3l2 -/- murine fibroblasts. RESULTS:We found that SCA28 cells carrying missense changes have normal levels of assembled m-AAA complexes, while the cells with a truncating pathogenic variant had only half of this amount. We disclosed inefficient mitochondrial fusion in SCA28 cells caused by increased OPA1 processing operated by hyperactivated OMA1. Notably, we found altered mitochondrial proteostasis to be the trigger of OMA1 activation in SCA28 cells, with pharmacological attenuation of mitochondrial protein synthesis resulting in stabilised levels of OMA1 and OPA1 long forms, which rescued mitochondrial fusion efficiency. Secondary to altered mitochondrial morphology, mitochondrial calcium uptake resulted decreased in SCA28 cells. CONCLUSION:Our data identify the earliest events in SCA28 pathogenesis and open new perspectives for therapy. By identifying similar mitochondrial phenotypes between SCA28 cells and AFG3L2+/- cells, our results support haploinsufficiency as the mechanism for the studied pathogenic variants.

Published
2019

7. Effect of BMI on safety of bariatric surgery during the COVID-19 pandemic, procedure choice, and safety protocols – An analysis from the GENEVA Study

Author

Pędziwiatr, Michał, Major, Piotr, Zarzycki, Piotr, Pantelis, Athanasios, Lapatsanis, Dimitris P., Stravodimos, Georgios, Matthys, Chris, Focquet, Marc, Vleeschouwers, Wouter, Spaventa, Antonio G., Zerrweck, Carlos, Vitiello, Antonio, Berardi, Giovanna, Musella, Mario, Sanchez-Meza, Alberto, Cantu, Felipe J., Jr, Mora, Fernando, Cantu, Marco A., Katakwar, Abhishek, Reddy, D. Nageshwar, Elmaleh, Haitham, Hassan, Mohammad, Elghandour, Abdelrahman, Elbanna, Mohey, Osman, Ahmed, Khan, Athar, Layani, Laurent, Kiran, Nalini, Velikorechin, Andrey, Solovyeva, Maria, Melali, Hamid, Shahabi, Shahab, Agrawal, Ashish, Shrivastava, Apoorv, Sharma, Ankur, Narwaria, Bhavya, Narwaria, Mahendra, Raziel, Asnat, Sakran, Nasser, Susmallian, Sergio, Karagöz, Levent, Akbaba, Murat, Pişkin, Salih Zeki, Balta, Ahmet Ziya, Senol, Zafer, Manno, Emilio, Iovino, Michele Giuseppe, Qassem, Mohamed, Arana-Garza, Sebastián, Povoas, Heitor P., Vilas-Boas, Marcos Leão, Li, Alan, Ammori, Basil J., Balamoun, Hany, Salman, Mohammed, Nasta, Amrit Manik, Goel, Ramen, Sánchez-Aguilar, Hugo, Herrera, Miguel F., Abou-Mrad, Adel, Cloix, Lucie, Mazzini, Guilherme Silva, Kristem, Leonardo, Lazaro, Andre, Campos, Jose, Bernardo, Joaquín, González, Jesús, Trindade, Carlos, Viveiros, Octávio, Ribeiro, Rui, Goitein, David, Hazzan, David, Segev, Lior, Beck, Tamar, Reyes, Hernán, Monterrubio, Jerónimo, García, Paulina, Benois, Marine, Kassir, Radwan, Contine, Alessandro, Elshafei, Moustafa, Aktas, Sueleyman, Weiner, Sylvia, Heidsieck, Till, Level, Luis, Pinango, Silvia, Ortega, Patricia Martinez, Moncada, Rafael, Valenti, Victor, Vlahović, Ivan, Boras, Zdenko, Liagre, Arnaud, Martini, Francesco, Juglard, Gildas, Motwani, Manish, Saggu, Sukhvinder Singh, Momani, Hazem Al, López, Luis Adolfo Aceves, Cortez, María Angelina Contreras, Zavala, Rodrigo Aceves, D'Haese, Christine, Kempeneers, Ivo, Himpens, Jacques, Lazzati, Andrea, Paolino, Luca, Bathaei, Sarah, Bedirli, Abdulkadir, Yavuz, Aydın, Büyükkasap, Çağrı, Özaydın, Safa, Kwiatkowski, Andrzej, Bartosiak, Katarzyna, Walędziak, Maciej, Santonicola, Antonella, Angrisani, Luigi, Iovino, Paola, Palma, Rossella, Iossa, Angelo, Boru, Cristian Eugeniu, Angelis, Francesco De, Silecchia, Gianfranco, Hussain, Abdulzahra, Balchandra, Srivinasan, Coltell, Izaskun Balciscueta, Pérez, Javier Lorenzo, Bohra, Ashok, Awan, Altaf K., Madhok, Brijesh, Leeder, Paul C., Awad, Sherif, Al-Khyatt, Waleed, Shoma, Ashraf, Elghadban, Hosam, Ghareeb, Sameh, Mathews, Bryan, Kurian, Marina, Larentzakis, Andreas, Vrakopoulou, Gavriella Zoi, Albanopoulos, Konstantinos, Bozdag, Ahemt, Lale, Azmi, Kirkil, Cuneyt, Dincer, Mursid, Bashir, Ahmad, Haddad, Ashraf, Hijleh, Leen Abu, Zilberstein, Bruno, de Marchi, Danilo Dallago, Souza, Willy Petrini, Brodén, Carl Magnus, Gislason, Hjörtur, Shah, Kamran, Ambrosi, Antonio, Pavone, Giovanna, Tartaglia, Nicola, Kumari Kona, S. Lakshmi, Kalyan, K., Perez, Cesar Ernesto Guevara, Botero, Miguel Alberto Forero, Covic, Adrian, Timofte, Daniel, Maxim, Madalina, Faraj, Dashti, Tseng, Larissa, Liem, Ronald, Ören, Gürdal, Dilektasli, Evren, Yalcin, Ilker, AlMukhtar, Hudhaifa, Hadad, Mohammed Al, Mohan, Rasmi, Arora, Naresh, Bedi, Digvijaysingh, Rives-Lange, Claire, Chevallier, Jean-Marc, Poghosyan, Tigran, Sebbag, Hugues, Zinaï, Lamia, Khaldi, Saadi, Mauchien, Charles, Mazza, Davide, Dinescu, Georgiana, Rea, Bernardo, Pérez-Galaz, Fernando, Zavala, Luis, Besa, Anais, Curell, Anna, Balibrea, Jose M., Vaz, Carlos, Galindo, Luis, Silva, Nelson, Caballero, José Luis Estrada, Sebastian, Sergio Ortiz, Marchesini, João Caetano Dallegrave, da Fonseca Pereira, Ricardo Arcanjo, Sobottka, Wagner Herbert, Fiolo, Felipe Eduardo, Turchi, Matias, Coelho, Antonio Claudio Jamel, Zacaron, Andre Luis, Barbosa, André, Quinino, Reynaldo, Menaldi, Gabriel, Paleari, Nicolás, Martinez-Duartez, Pedro, de Aragon Ramírez de Esparza, Gabriel Martínez, Esteban, Valentin Sierra, Torres, Antonio, Garcia-Galocha, Jose Luis, Josa, Miguel, Pacheco-Garcia, Jose Manuel, Mayo-Ossorio, Maria Angeles, Chowbey, Pradeep, Soni, Vandana, de Vasconcelos Cunha, Hercio Azevedo, Castilho, Michel Victor, Ferreira, Rafael Meneguzzi Alves, Barreiro, Thiago Alvim, Charalabopoulos, Alexandros, Sdralis, Elias, Davakis, Spyridon, Bomans, Benoit, Dapri, Giovanni, Belle, Koenraad Van, Takieddine, Mazen, Vaneukem, Pol, Karaca, Esma Seda Akalın, Karaca, Fatih Can, Sumer, Aziz, Peksen, Caghan, Savas, Osman Anil, Chousleb, Elias, Elmokayed, Fahad, Fakhereldin, Islam, Aboshanab, Hany Mohamed, Swelium, Talal, Gudal, Ahmad, Gamloo, Lamees, Ugale, Ayushka, Ugale, Surendra, Boeker, Clara, Reetz, Christian, Hakami, Ibrahim Ali, Mall, Julian, Alexandrou, Andreas, Baili, Efstratia, Bodnar, Zsolt, Maleckas, Almantas, Gudaityte, Rita, Guldogan, Cem Emir, Gundogdu, Emre, Ozmen, Mehmet Mahir, Thakkar, Deepti, Dukkipati, Nandakishore, Shah, Poonam Shashank, Shah, Shashank Subhashchandra, Shah, Simran Shashank, Adil, Md Tanveer, Jambulingam, Periyathambi, Mamidanna, Ravikrishna, Whitelaw, Douglas, Jain, Vigyan, Veetil, Deepa Kizhakke, Wadhawan, Randeep, Torres, Max, Tinoco, Tabata, Leclercq, Wouter, Romeijn, Marleen, van de Pas, Kelly, Alkhazraji, Ali K., Taha, Safwan A., Ustun, Murat, Yigit, Taner, Inam, Aatif, Burhanulhaq, Muhammad, Pazouki, Abdolreza, Eghbali, Foolad, Kermansaravi, Mohammad, Jazi, Amir Hosein Davarpanah, Mahmoudieh, Mohsen, Mogharehabed, Neda, Tsiotos, Gregory, Stamou, Konstantinos, Barrera Rodriguez, Francisco J, Rojas Navarro, Marco A., MOhamed Torres, Omar, Martinez, Sergio Lopez, Tamez, Elda Rocio Maltos, Millan Cornejo, Gustavo A., Flores, Jose Eduardo Garcia, Mohammed, Diya Aldeen, Elfawal, Mohamad Hayssam, Shabbir, Asim, Guowei, Kim, So, Jimmy By, Kaplan, Elif Tuğçe, Kaplan, Mehmet, Kaplan, Tuğba, Pham, DangTuan, Rana, Gurteshwar, Kappus, Mojdeh, Gadani, Riddish, Kahitan, Manish, Pokharel, Koshish, Osborne, Alan, Pournaras, Dimitri, Hewes, James, Napolitano, Errichetta, Chiappetta, Sonja, Bottino, Vincenzo, Dorado, Evelyn, Schoettler, Axel, Gaertner, Daniel, Fedtke, Katharina, Aguilar-Espinosa, Francisco, Aceves-Lozano, Saul, Balani, Alessandro, Nagliati, Carlo, Pennisi, Damiano, Rizzi, Andrea, Frattini, Francesco, Foschi, Diego, Benuzzi, Laura, Parikh, Chirag, Shah, Harshil, Pinotti, Enrico, Montuori, Mauro, Borrelli, Vincenzo, Dargent, Jerome, Copaescu, Catalin A, Hutopila, Ionut, Smeu, Bogdan, Witteman, Bart, Hazebroek, Eric, Deden, Laura, Heusschen, Laura, Okkema, Sietske, Aufenacker, Theo, den Hengst, Willem, Vening, Wouter, van der Burgh, Yonta, Ghazal, Ahmad, Ibrahim, Hamza, Niazi, Mourad, Alkhaffaf, Bilal, Altarawni, Mohammad, Cesana, Giovanni Carlo, Anselmino, Marco, Uccelli, Matteo, Olmi, Stefano, Stier, Christine, Akmanlar, Tahsin, Sonnenberg, Thomas, Schieferbein, Uwe, Marcolini, Alejandro, Awruch, Diego, Vicentin, Marco, de Souza Bastos, Eduardo Lemos, Gregorio, Samuel Azenha, Ahuja, Anmol, Mittal, Tarun, Bolckmans, Roel, Wiggins, Tom, Baratte, Clément, Wisnewsky, Judith Aron, Genser, Laurent, Chong, Lynn, Taylor, Lillian, Ward, Salena, Hi, Michael W., Heneghan, Helen, Fearon, Naomi, Plamper, Andreas, Rheinwalt, Karl, Geoghegan, Justin, Ng, Kin Cheung, Kaseja, Krzysztof, Kotowski, Maciej, Samarkandy, Tarig A., Leyva-Alvizo, Adolfo, Corzo-Culebro, Lourdes, Wang, Cunchuan, Yang, Wah, Dong, Zhiyong, Riera, Manel, Jain, Rajesh, Hamed, Hosam, Said, Mohammed, Zarzar, Katia, Garcia, Manuel, Türkçapar, Ahmet Gökhan, Şen, Ozan, Baldini, Edoardo, Conti, Luigi, Wietzycoski, Cacio, Lopes, Eduardo, Pintar, Tadeja, Salobir, Jure, Aydin, Cengiz, Atici, Semra Demirli, Ergin, Anıl, Ciyiltepe, Huseyin, Bozkurt, Mehmet Abdussamet, Kizilkaya, Mehmet Celal, Onalan, Nezihe Berrin Dodur, Binti Ahmad Zuber, Mariana Nabila, Wong, Wei Jin, Garcia, Amador, Vidal, Laura, Beisani, Marc, Pasquier, Jorge, Vilallonga, Ramon, Sharma, Sharad, Parmar, Chetan, Lee, Lyndcie, Sufi, Pratik, Sinan, Hüseyin, Saydam, Mehmet, Singhal, Rishi, Omar, Islam, Ludwig, Christian, Tahrani, Abd A., and Mahawar, Kamal

Published
2022
Full Text
View/download PDF

10. Debris flows and debris avalanches initiation and runout susceptibility assessment in Campania region (Italy)

Author

Tufano Rita, Mazza Davide, Guadagno Francesco Maria, De Vita Pantaleone, Russo Giacomo, and Revellino Paola

Subjects
Environmental sciences, GE1-350
Abstract

Sectors of the Campania region (southern Italy), where pyroclastic airfall deposits cover carbonate slopes, have frequently experienced debris avalanches and debris flows. These landslides are triggered by heavy rainfall and in the last century caused severe destruction and hundreds of deaths. Their occurrence is controlled by the interaction of several factors, both natural and human induced. The initial failure is linked with the presence of morphological discontinuities such as rocky scarps and road cuts, which interrupt the stratigraphical continuity of an “infinite slope”. Here the main criteria for susceptibility analysis are defined trying to develop a procedure for identify highly-susceptible sources, runout and invasion areas.

Published
2023
Full Text
View/download PDF

14. PML modulates epigenetic composition of chromatin to regulate expression of pro-metastatic genes in triple-negative breast cancer

Author

Fracassi, Cristina, primary, Ugge', Martina, additional, Abdelhalim, Mohamed, additional, Zapparoli, Ettore, additional, Simoni, Matilde, additional, Magliulo, Daniela, additional, Mazza, Davide, additional, Lazarevic, Dejan, additional, Morelli, Marco J, additional, Collas, Philippe, additional, and Bernardi, Rosa, additional

Published
2023
Full Text
View/download PDF

15. 3D photopolymerized microstructured scaffolds influence nuclear deformation, nucleo/cytoskeletal protein organization, and gene regulation in mesenchymal stem cells

Author

Donnaloja, Francesca, primary, Raimondi, Manuela Teresa, additional, Messa, Letizia, additional, Barzaghini, Bianca, additional, Carnevali, Federica, additional, Colombo, Emanuele, additional, Mazza, Davide, additional, Martinelli, Chiara, additional, Boeri, Lucia, additional, Rey, Federica, additional, Cereda, Cristina, additional, Osellame, Roberto, additional, Cerullo, Giulio, additional, Carelli, Stephana, additional, Soncini, Monica, additional, and Jacchetti, Emanuela, additional

Published
2023
Full Text
View/download PDF

19. Reticulon 3–dependent ER-PM contact sites control EGFR nonclathrin endocytosis

Author

Caldieri, Giusi, Barbieri, Elisa, Nappo, Gilda, Raimondi, Andrea, Bonora, Massimo, Conte, Alexia, Verhoef, Lisette G. G. C., Confalonieri, Stefano, Malabarba, Maria Grazia, Bianchi, Fabrizio, Cuomo, Alessandro, Bonaldi, Tiziana, Martini, Emanuele, Mazza, Davide, Pinton, Paolo, Tacchetti, Carlo, Polo, Simona, Di Fiore, Pier Paolo, and Sigismund, Sara

Published
2017

20. HNF4α, SP1 and c-myc are master regulators of CNS autoimmunity

Author

Colombo, Emanuela, primary, Di Dario, Marco, additional, Menon, Ramesh, additional, Valente, Maria Maddalena, additional, Bassani, Claudia, additional, Sarno, Nicole, additional, Mazza, Davide, additional, Montini, Federico, additional, Moiola, Lucia, additional, Comi, Giancarlo, additional, Martinelli, Vittorio, additional, and Farina, Cinthia, additional

Published
2023
Full Text
View/download PDF

21. MULTI-TEMPORAL EVOLUTION ANALYSIS OF MARONTI CLIFF (ISCHIA ISLAND, ITALY) DERIVED FROM MULTI-PERSPECTIVE PHOTOGRAPHIC DATASETS.

Author

PARENTE, LUIGI, COCCA, JLENIA, MAZZA, DAVIDE, ALBANESE, VINCENZO, GUADAGNO, FRANCESCO MARIA, and REVELLINO, PAOLA

Subjects
BEACH erosion, ESTIMATION theory, POINT cloud, ROCKFALL, EROSION, CLIFFS
Abstract

Coastal cliff erosion is a significant hazard for the safety of people, buildings, utilities and infrastructure, given the sudden and episodic nature of the retreat process in time and space. Thus, understanding past retreat trends and a regular diagnosis of the cliff face condition is fundamental for risk management. In this study we show preliminary results of a project aimed at the definition of the coastal erosion (in terms of temporal and spatial scales) of a small portion of cliff located along the Maronti beach in Ischia, Italy. Drone-based and terrestrial acquisition approaches offered the opportunity to exploit photogrammetric techniques to estimate the spatial and temporal rate of change of the investigated portion of cliff. In this study, cliff face topographical evolution is evaluated out by comparing the results obtained from three photographic datasets (variable approach either boat and UAV-based) obtained in 2011, 2021 and 2023. Spatial distribution of two main instability events dated back to 2020 and 2022 were well represented in the maps of change generated with the M3C2 algorithm. The comparison of point clouds for the period 2011-2021 and 2021-2023 produced max retreat rate of the cliff face of approximately 12 and 25 m, respectively. Results highlighted the need for robust co-registration methods to accurately estimate erosion rates. Critical issues are discussed to highlight potentials and limitations encountered with the abovementioned multi-temporal cliff evolution assessment techniques. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

24. Myelomonocytic cells in giant cell arteritis activate trained immunity programs sustaining inflammation and cytokine production

Author

Cantoni, E, Merelli, I, Stefanoni, D, Tomelleri, A, Campochiaro, C, Giordano, V, Panigada, M, Baldissera, E, Merlo Pich, L, Natoli, V, Ziogas, A, Domínguez-Andrés, J, De Luca, G, Mazza, D, Zambrano, S, Gnani, D, Ferrarini, M, Ferrero, E, Agresti, A, Vergani, B, Leone, B, Cenci, S, Ravelli, A, Matucci-Cerinic, M, D'Alessandro, A, Joosten, L, Dagna, L, Netea, M, Molteni, R, Cavalli, G, Cantoni, Eleonora, Merelli, Ivan, Stefanoni, Davide, Tomelleri, Alessandro, Campochiaro, Corrado, Giordano, Vito, Panigada, Maddalena, Baldissera, Elena M, Merlo Pich, Laura, Natoli, Valentina, Ziogas, Athanasios, Domínguez-Andrés, Jorge, De Luca, Giacomo, Mazza, Davide, Zambrano, Samuel, Gnani, Daniela, Ferrarini, Marina, Ferrero, Elisabetta, Agresti, Alessandra, Vergani, Barbara, Leone, Biagio Eugenio, Cenci, Simone, Ravelli, Angelo, Matucci-Cerinic, Marco, D'Alessandro, Angelo, Joosten, Leo A B, Dagna, Lorenzo, Netea, Mihai G, Molteni, Raffaella, Cavalli, Giulio, Cantoni, E, Merelli, I, Stefanoni, D, Tomelleri, A, Campochiaro, C, Giordano, V, Panigada, M, Baldissera, E, Merlo Pich, L, Natoli, V, Ziogas, A, Domínguez-Andrés, J, De Luca, G, Mazza, D, Zambrano, S, Gnani, D, Ferrarini, M, Ferrero, E, Agresti, A, Vergani, B, Leone, B, Cenci, S, Ravelli, A, Matucci-Cerinic, M, D'Alessandro, A, Joosten, L, Dagna, L, Netea, M, Molteni, R, Cavalli, G, Cantoni, Eleonora, Merelli, Ivan, Stefanoni, Davide, Tomelleri, Alessandro, Campochiaro, Corrado, Giordano, Vito, Panigada, Maddalena, Baldissera, Elena M, Merlo Pich, Laura, Natoli, Valentina, Ziogas, Athanasios, Domínguez-Andrés, Jorge, De Luca, Giacomo, Mazza, Davide, Zambrano, Samuel, Gnani, Daniela, Ferrarini, Marina, Ferrero, Elisabetta, Agresti, Alessandra, Vergani, Barbara, Leone, Biagio Eugenio, Cenci, Simone, Ravelli, Angelo, Matucci-Cerinic, Marco, D'Alessandro, Angelo, Joosten, Leo A B, Dagna, Lorenzo, Netea, Mihai G, Molteni, Raffaella, and Cavalli, Giulio

Abstract

Objective: Trained immunity (TI) is a de facto memory program of innate immune cells, characterized by immunometabolic and epigenetic changes sustaining enhanced production of cytokines. TI evolved as a protective mechanism against infections; however, inappropriate activation can cause detrimental inflammation and might be implicated in the pathogenesis of chronic inflammatory diseases. In this study, we investigated the role of TI in the pathogenesis of giant cell arteritis (GCA), a large-vessel vasculitis characterized by aberrant macrophage activation and excess cytokine production. Methods: Monocytes from GCA patients and from age- and sex-matched healthy donors were subjected to polyfunctional studies, including cytokine production assays at baseline and following stimulation, intracellular metabolomics, chromatin immunoprecipitation-qPCR, and combined ATAC/RNA sequencing. Immunometabolic activation (i.e. glycolysis) was assessed in inflamed vessels of GCA patients with FDG-PET and immunohistochemistry (IHC), and the role of this pathway in sustaining cytokine production was confirmed with selective pharmacologic inhibition in GCA monocytes. Results: GCA monocytes exhibited hallmark molecular features of TI. Specifically, these included enhanced IL-6 production upon stimulation, typical immunometabolic changes (e.g. increased glycolysis and glutaminolysis) and epigenetic changes promoting enhanced transcription of genes governing pro-inflammatory activation. Immunometabolic changes of TI (i.e. glycolysis) were a feature of myelomonocytic cells in GCA lesions and were required for enhanced cytokine production. Conclusions: Myelomonocytic cells in GCA activate TI programs sustaining enhanced inflammatory activation with excess cytokine production.

Published
2023

27. Myelomonocytic cells in giant cell arteritis activate trained immunity programs sustaining inflammation and cytokine production.

Author

Cantoni, Eleonora, Merelli, Ivan, Stefanoni, Davide, Tomelleri, Alessandro, Campochiaro, Corrado, Giordano, Vito, Panigada, Maddalena, Baldissera, Elena M, Pich, Laura Merlo, Natoli, Valentina, Ziogas, Athanasios, Domínguez-Andrés, Jorge, Luca, Giacomo De, Mazza, Davide, Zambrano, Samuel, Gnani, Daniela, Ferrarini, Marina, Ferrero, Elisabetta, Agresti, Alessandra, and Vergani, Barbara

Subjects
CYTOKINES, NATURAL immunity, SEQUENCE analysis, INFLAMMATION, CHRONIC diseases, IMMUNOHISTOCHEMISTRY, METABOLOMICS, GIANT cell arteritis, GENE expression, GENES, RESEARCH funding, MONOCYTES, VASCULITIS
Abstract

Objective Trained immunity (TI) is a de facto memory program of innate immune cells, characterized by immunometabolic and epigenetic changes sustaining enhanced production of cytokines. TI evolved as a protective mechanism against infections; however, inappropriate activation can cause detrimental inflammation and might be implicated in the pathogenesis of chronic inflammatory diseases. In this study, we investigated the role of TI in the pathogenesis of giant cell arteritis (GCA), a large-vessel vasculitis characterized by aberrant macrophage activation and excess cytokine production. Methods Monocytes from GCA patients and from age- and sex-matched healthy donors were subjected to polyfunctional studies, including cytokine production assays at baseline and following stimulation, intracellular metabolomics, chromatin immunoprecipitation-qPCR, and combined ATAC/RNA sequencing. Immunometabolic activation (i.e. glycolysis) was assessed in inflamed vessels of GCA patients with FDG-PET and immunohistochemistry (IHC), and the role of this pathway in sustaining cytokine production was confirmed with selective pharmacologic inhibition in GCA monocytes. Results GCA monocytes exhibited hallmark molecular features of TI. Specifically, these included enhanced IL-6 production upon stimulation, typical immunometabolic changes (e.g. increased glycolysis and glutaminolysis) and epigenetic changes promoting enhanced transcription of genes governing pro-inflammatory activation. Immunometabolic changes of TI (i.e. glycolysis) were a feature of myelomonocytic cells in GCA lesions and were required for enhanced cytokine production. Conclusions Myelomonocytic cells in GCA activate TI programs sustaining enhanced inflammatory activation with excess cytokine production. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

30. Chromatin organization drives the exploration strategy of nuclear factors

Author

Mazzocca, Matteo, primary, Loffreda, Alessia, additional, Colombo, Emanuele, additional, Fillot, Tom, additional, Gnani, Daniela, additional, Falletta, Paola, additional, Monteleone, Emanuele, additional, Capozi, Serena, additional, Bertrand, Edouard, additional, Legube, Gaelle, additional, Lavagnino, Zeno, additional, Tacchetti, Carlo, additional, and Mazza, Davide, additional

Published
2022
Full Text
View/download PDF

31. A Framework for the Development of Haptic-Enhanced Web Applications

Author

Comai, Sara, Mazza, Davide, Guarinoni, Andrea, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Brambilla, Marco, editor, Tokuda, Takehiro, editor, and Tolksdorf, Robert, editor

Published
2012
Full Text
View/download PDF

32. Usability Assessment of a Multimodal Visual-Haptic Framework for Chemistry Education

Author

Comai, Sara, Mazza, Davide, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Campos, Pedro, editor, Graham, Nicholas, editor, Jorge, Joaquim, editor, Nunes, Nuno, editor, Palanque, Philippe, editor, and Winckler, Marco, editor

Published
2011
Full Text
View/download PDF

34. A Haptic-Based Framework for Chemistry Education

Author

Comai, Sara, Mazza, Davide, Mureddu, Lorenzo, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Wolpers, Martin, editor, Kirschner, Paul A., editor, Scheffel, Maren, editor, Lindstaedt, Stefanie, editor, and Dimitrova, Vania, editor

Published
2010
Full Text
View/download PDF

35. A Haptic-Enhanced System for Molecular Sensing

Author

Comai, Sara, Mazza, Davide, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Gross, Tom, editor, Gulliksen, Jan, editor, Kotzé, Paula, editor, Oestreicher, Lars, editor, Palanque, Philippe, editor, Prates, Raquel Oliveira, editor, and Winckler, Marco, editor

Published
2009
Full Text
View/download PDF

36. Context-Driven Hypertext Specification

Author

Comai, Sara, Mazza, Davide, Quintarelli, Elisa, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Gaedke, Martin, editor, Grossniklaus, Michael, editor, and Díaz, Oscar, editor

Published
2009
Full Text
View/download PDF

37. Two-Photon Excitation Fluorescence Microscopy

Author

Diaspro, Alberto, Schneider, Marc, Bianchini, Paolo, Caorsi, Valentina, Mazza, Davide, Pesce, Mattia, Testa, Ilaria, Vicidomini, Giuseppe, Usai, Cesare, Van den Bos, A., Hawkes, Peter W., editor, and Spence, John C. H., editor

Published
2007
Full Text
View/download PDF

39. UV and violet light can Neutralize SARS-CoV-2 Infectivity

Author

Biasin, Mara, primary, Strizzi, Sergio, additional, Bianco, Andrea, additional, Macchi, Alberto, additional, Utyro, Olga, additional, Pareschi, Giovanni, additional, Loffreda, Alessia, additional, Cavalleri, Adalberto, additional, Lualdi, Manuela, additional, Trabattoni, Daria, additional, Tacchetti, Carlo, additional, Mazza, Davide, additional, and Clerici, Mario, additional

Published
2022
Full Text
View/download PDF

40. Purkinje neuron [Ca.sup.2+] influx reduction rescues ataxia in SCA28 model

Author

Maltecca, Francesca, Baseggio, Elisa, Consolato, Francesco, Mazza, Davide, Podini, Paola, Young, Jr., Samuel M., Drago, Ilaria, Bahr, Ben A., Puliti, Aldamaria, Codazzi, Franca, Quattrini, Angelo, and Casari, Giorgio

Subjects
Gene mutations -- Health aspects -- Research, Neurons -- Physiological aspects -- Research, Spinocerebellar ataxia -- Research -- Risk factors -- Genetic aspects, Health care industry
Abstract

Spinocerebellar ataxia type 28 (SCA28) is a neurodegenerative disease caused by mutations of the mitochondrial protease AFG3L2. The SCA28 mouse model, which is haploinsufficient for Afg3l2, exhibits a progressive decline in motor function and displays dark degeneration of Purkinje cells (PC-DCD) of mitochondrial origin. Here, we determined that mitochondria in cultured Afg3l2-deficient PCs ineffectively buffer evoked [Ca.sup.2+] peaks, resulting in enhanced cytoplasmic [Ca.sup.2+] concentrations, which subsequently triggers PC-DCD. This [Ca.sup.2+]-handling defect is the result of negative synergism between mitochondrial depolarization and altered organelle trafficking to PC dendrites in Afg3l2-mutant cells. In SCA28 mice, partial genetic silencing of the metabotropic glutamate receptor mGluR1 decreased [Ca.sup.2+] influx in PCs and reversed the ataxic phenotype. Moreover, administration of the β-lactam antibiotic ceftriaxone, which promotes synaptic glutamate clearance, thereby reducing [Ca.sup.2+] influx, improved ataxia-associated phenotypes in SCA28 mice when given either prior to or after symptom onset. Together, the results of this study indicate that ineffective mitochondrial [Ca.sup.2+] handling in PCs underlies SCA28 pathogenesis and suggest that strategies that lower glutamate stimulation of PCs should be further explored as a potential treatment for SCA28 patients., Introduction SCA28 is a form of dominant cerebellar ataxia characterized by unbalanced standing, gait incoordination, hyperreflexia of the lower limbs, nystagmus, and ophthalmoparesis (1). Several SCA28-causing missense mutations have been [...]

Published
2015
Full Text
View/download PDF

42. Effect of BMI on safety of bariatric surgery during the COVID-19 pandemic, procedure choice, and safety protocols – An analysis from the GENEVA Study

Author

Singhal, Rishi, primary, Omar, Islam, additional, Madhok, Brijesh, additional, Ludwig, Christian, additional, Tahrani, Abd A., additional, Mahawar, Kamal, additional, Pędziwiatr, Michał, additional, Major, Piotr, additional, Zarzycki, Piotr, additional, Pantelis, Athanasios, additional, Lapatsanis, Dimitris P., additional, Stravodimos, Georgios, additional, Matthys, Chris, additional, Focquet, Marc, additional, Vleeschouwers, Wouter, additional, Spaventa, Antonio G., additional, Zerrweck, Carlos, additional, Vitiello, Antonio, additional, Berardi, Giovanna, additional, Musella, Mario, additional, Sanchez-Meza, Alberto, additional, Cantu, Felipe J., additional, Mora, Fernando, additional, Cantu, Marco A., additional, Katakwar, Abhishek, additional, Reddy, D. Nageshwar, additional, Elmaleh, Haitham, additional, Hassan, Mohammad, additional, Elghandour, Abdelrahman, additional, Elbanna, Mohey, additional, Osman, Ahmed, additional, Khan, Athar, additional, Layani, Laurent, additional, Kiran, Nalini, additional, Velikorechin, Andrey, additional, Solovyeva, Maria, additional, Melali, Hamid, additional, Shahabi, Shahab, additional, Agrawal, Ashish, additional, Shrivastava, Apoorv, additional, Sharma, Ankur, additional, Narwaria, Bhavya, additional, Narwaria, Mahendra, additional, Raziel, Asnat, additional, Sakran, Nasser, additional, Susmallian, Sergio, additional, Karagöz, Levent, additional, Akbaba, Murat, additional, Pişkin, Salih Zeki, additional, Balta, Ahmet Ziya, additional, Senol, Zafer, additional, Manno, Emilio, additional, Iovino, Michele Giuseppe, additional, Qassem, Mohamed, additional, Arana-Garza, Sebastián, additional, Povoas, Heitor P., additional, Vilas-Boas, Marcos Leão, additional, Li, Alan, additional, Ammori, Basil J., additional, Balamoun, Hany, additional, Salman, Mohammed, additional, Nasta, Amrit Manik, additional, Goel, Ramen, additional, Sánchez-Aguilar, Hugo, additional, Herrera, Miguel F., additional, Abou-Mrad, Adel, additional, Cloix, Lucie, additional, Mazzini, Guilherme Silva, additional, Kristem, Leonardo, additional, Lazaro, Andre, additional, Campos, Jose, additional, Bernardo, Joaquín, additional, González, Jesús, additional, Trindade, Carlos, additional, Viveiros, Octávio, additional, Ribeiro, Rui, additional, Goitein, David, additional, Hazzan, David, additional, Segev, Lior, additional, Beck, Tamar, additional, Reyes, Hernán, additional, Monterrubio, Jerónimo, additional, García, Paulina, additional, Benois, Marine, additional, Kassir, Radwan, additional, Contine, Alessandro, additional, Elshafei, Moustafa, additional, Aktas, Sueleyman, additional, Weiner, Sylvia, additional, Heidsieck, Till, additional, Level, Luis, additional, Pinango, Silvia, additional, Ortega, Patricia Martinez, additional, Moncada, Rafael, additional, Valenti, Victor, additional, Vlahović, Ivan, additional, Boras, Zdenko, additional, Liagre, Arnaud, additional, Martini, Francesco, additional, Juglard, Gildas, additional, Motwani, Manish, additional, Saggu, Sukhvinder Singh, additional, Momani, Hazem Al, additional, López, Luis Adolfo Aceves, additional, Cortez, María Angelina Contreras, additional, Zavala, Rodrigo Aceves, additional, D'Haese, Christine, additional, Kempeneers, Ivo, additional, Himpens, Jacques, additional, Lazzati, Andrea, additional, Paolino, Luca, additional, Bathaei, Sarah, additional, Bedirli, Abdulkadir, additional, Yavuz, Aydın, additional, Büyükkasap, Çağrı, additional, Özaydın, Safa, additional, Kwiatkowski, Andrzej, additional, Bartosiak, Katarzyna, additional, Walędziak, Maciej, additional, Santonicola, Antonella, additional, Angrisani, Luigi, additional, Iovino, Paola, additional, Palma, Rossella, additional, Iossa, Angelo, additional, Boru, Cristian Eugeniu, additional, Angelis, Francesco De, additional, Silecchia, Gianfranco, additional, Hussain, Abdulzahra, additional, Balchandra, Srivinasan, additional, Coltell, Izaskun Balciscueta, additional, Pérez, Javier Lorenzo, additional, Bohra, Ashok, additional, Awan, Altaf K., additional, Leeder, Paul C., additional, Awad, Sherif, additional, Al-Khyatt, Waleed, additional, Shoma, Ashraf, additional, Elghadban, Hosam, additional, Ghareeb, Sameh, additional, Mathews, Bryan, additional, Kurian, Marina, additional, Larentzakis, Andreas, additional, Vrakopoulou, Gavriella Zoi, additional, Albanopoulos, Konstantinos, additional, Bozdag, Ahemt, additional, Lale, Azmi, additional, Kirkil, Cuneyt, additional, Dincer, Mursid, additional, Bashir, Ahmad, additional, Haddad, Ashraf, additional, Hijleh, Leen Abu, additional, Zilberstein, Bruno, additional, de Marchi, Danilo Dallago, additional, Souza, Willy Petrini, additional, Brodén, Carl Magnus, additional, Gislason, Hjörtur, additional, Shah, Kamran, additional, Ambrosi, Antonio, additional, Pavone, Giovanna, additional, Tartaglia, Nicola, additional, Kumari Kona, S. Lakshmi, additional, Kalyan, K., additional, Perez, Cesar Ernesto Guevara, additional, Botero, Miguel Alberto Forero, additional, Covic, Adrian, additional, Timofte, Daniel, additional, Maxim, Madalina, additional, Faraj, Dashti, additional, Tseng, Larissa, additional, Liem, Ronald, additional, Ören, Gürdal, additional, Dilektasli, Evren, additional, Yalcin, Ilker, additional, AlMukhtar, Hudhaifa, additional, Hadad, Mohammed Al, additional, Mohan, Rasmi, additional, Arora, Naresh, additional, Bedi, Digvijaysingh, additional, Rives-Lange, Claire, additional, Chevallier, Jean-Marc, additional, Poghosyan, Tigran, additional, Sebbag, Hugues, additional, Zinaï, Lamia, additional, Khaldi, Saadi, additional, Mauchien, Charles, additional, Mazza, Davide, additional, Dinescu, Georgiana, additional, Rea, Bernardo, additional, Pérez-Galaz, Fernando, additional, Zavala, Luis, additional, Besa, Anais, additional, Curell, Anna, additional, Balibrea, Jose M., additional, Vaz, Carlos, additional, Galindo, Luis, additional, Silva, Nelson, additional, Caballero, José Luis Estrada, additional, Sebastian, Sergio Ortiz, additional, Marchesini, João Caetano Dallegrave, additional, da Fonseca Pereira, Ricardo Arcanjo, additional, Sobottka, Wagner Herbert, additional, Fiolo, Felipe Eduardo, additional, Turchi, Matias, additional, Coelho, Antonio Claudio Jamel, additional, Zacaron, Andre Luis, additional, Barbosa, André, additional, Quinino, Reynaldo, additional, Menaldi, Gabriel, additional, Paleari, Nicolás, additional, Martinez-Duartez, Pedro, additional, de Aragon Ramírez de Esparza, Gabriel Martínez, additional, Esteban, Valentin Sierra, additional, Torres, Antonio, additional, Garcia-Galocha, Jose Luis, additional, Josa, Miguel, additional, Pacheco-Garcia, Jose Manuel, additional, Mayo-Ossorio, Maria Angeles, additional, Chowbey, Pradeep, additional, Soni, Vandana, additional, de Vasconcelos Cunha, Hercio Azevedo, additional, Castilho, Michel Victor, additional, Ferreira, Rafael Meneguzzi Alves, additional, Barreiro, Thiago Alvim, additional, Charalabopoulos, Alexandros, additional, Sdralis, Elias, additional, Davakis, Spyridon, additional, Bomans, Benoit, additional, Dapri, Giovanni, additional, Belle, Koenraad Van, additional, Takieddine, Mazen, additional, Vaneukem, Pol, additional, Karaca, Esma Seda Akalın, additional, Karaca, Fatih Can, additional, Sumer, Aziz, additional, Peksen, Caghan, additional, Savas, Osman Anil, additional, Chousleb, Elias, additional, Elmokayed, Fahad, additional, Fakhereldin, Islam, additional, Aboshanab, Hany Mohamed, additional, Swelium, Talal, additional, Gudal, Ahmad, additional, Gamloo, Lamees, additional, Ugale, Ayushka, additional, Ugale, Surendra, additional, Boeker, Clara, additional, Reetz, Christian, additional, Hakami, Ibrahim Ali, additional, Mall, Julian, additional, Alexandrou, Andreas, additional, Baili, Efstratia, additional, Bodnar, Zsolt, additional, Maleckas, Almantas, additional, Gudaityte, Rita, additional, Guldogan, Cem Emir, additional, Gundogdu, Emre, additional, Ozmen, Mehmet Mahir, additional, Thakkar, Deepti, additional, Dukkipati, Nandakishore, additional, Shah, Poonam Shashank, additional, Shah, Shashank Subhashchandra, additional, Shah, Simran Shashank, additional, Adil, Md Tanveer, additional, Jambulingam, Periyathambi, additional, Mamidanna, Ravikrishna, additional, Whitelaw, Douglas, additional, Jain, Vigyan, additional, Veetil, Deepa Kizhakke, additional, Wadhawan, Randeep, additional, Torres, Max, additional, Tinoco, Tabata, additional, Leclercq, Wouter, additional, Romeijn, Marleen, additional, van de Pas, Kelly, additional, Alkhazraji, Ali K., additional, Taha, Safwan A., additional, Ustun, Murat, additional, Yigit, Taner, additional, Inam, Aatif, additional, Burhanulhaq, Muhammad, additional, Pazouki, Abdolreza, additional, Eghbali, Foolad, additional, Kermansaravi, Mohammad, additional, Jazi, Amir Hosein Davarpanah, additional, Mahmoudieh, Mohsen, additional, Mogharehabed, Neda, additional, Tsiotos, Gregory, additional, Stamou, Konstantinos, additional, Barrera Rodriguez, Francisco J, additional, Rojas Navarro, Marco A., additional, MOhamed Torres, Omar, additional, Martinez, Sergio Lopez, additional, Tamez, Elda Rocio Maltos, additional, Millan Cornejo, Gustavo A., additional, Flores, Jose Eduardo Garcia, additional, Mohammed, Diya Aldeen, additional, Elfawal, Mohamad Hayssam, additional, Shabbir, Asim, additional, Guowei, Kim, additional, So, Jimmy By, additional, Kaplan, Elif Tuğçe, additional, Kaplan, Mehmet, additional, Kaplan, Tuğba, additional, Pham, DangTuan, additional, Rana, Gurteshwar, additional, Kappus, Mojdeh, additional, Gadani, Riddish, additional, Kahitan, Manish, additional, Pokharel, Koshish, additional, Osborne, Alan, additional, Pournaras, Dimitri, additional, Hewes, James, additional, Napolitano, Errichetta, additional, Chiappetta, Sonja, additional, Bottino, Vincenzo, additional, Dorado, Evelyn, additional, Schoettler, Axel, additional, Gaertner, Daniel, additional, Fedtke, Katharina, additional, Aguilar-Espinosa, Francisco, additional, Aceves-Lozano, Saul, additional, Balani, Alessandro, additional, Nagliati, Carlo, additional, Pennisi, Damiano, additional, Rizzi, Andrea, additional, Frattini, Francesco, additional, Foschi, Diego, additional, Benuzzi, Laura, additional, Parikh, Chirag, additional, Shah, Harshil, additional, Pinotti, Enrico, additional, Montuori, Mauro, additional, Borrelli, Vincenzo, additional, Dargent, Jerome, additional, Copaescu, Catalin A, additional, Hutopila, Ionut, additional, Smeu, Bogdan, additional, Witteman, Bart, additional, Hazebroek, Eric, additional, Deden, Laura, additional, Heusschen, Laura, additional, Okkema, Sietske, additional, Aufenacker, Theo, additional, den Hengst, Willem, additional, Vening, Wouter, additional, van der Burgh, Yonta, additional, Ghazal, Ahmad, additional, Ibrahim, Hamza, additional, Niazi, Mourad, additional, Alkhaffaf, Bilal, additional, Altarawni, Mohammad, additional, Cesana, Giovanni Carlo, additional, Anselmino, Marco, additional, Uccelli, Matteo, additional, Olmi, Stefano, additional, Stier, Christine, additional, Akmanlar, Tahsin, additional, Sonnenberg, Thomas, additional, Schieferbein, Uwe, additional, Marcolini, Alejandro, additional, Awruch, Diego, additional, Vicentin, Marco, additional, de Souza Bastos, Eduardo Lemos, additional, Gregorio, Samuel Azenha, additional, Ahuja, Anmol, additional, Mittal, Tarun, additional, Bolckmans, Roel, additional, Wiggins, Tom, additional, Baratte, Clément, additional, Wisnewsky, Judith Aron, additional, Genser, Laurent, additional, Chong, Lynn, additional, Taylor, Lillian, additional, Ward, Salena, additional, Hi, Michael W., additional, Heneghan, Helen, additional, Fearon, Naomi, additional, Plamper, Andreas, additional, Rheinwalt, Karl, additional, Geoghegan, Justin, additional, Ng, Kin Cheung, additional, Kaseja, Krzysztof, additional, Kotowski, Maciej, additional, Samarkandy, Tarig A., additional, Leyva-Alvizo, Adolfo, additional, Corzo-Culebro, Lourdes, additional, Wang, Cunchuan, additional, Yang, Wah, additional, Dong, Zhiyong, additional, Riera, Manel, additional, Jain, Rajesh, additional, Hamed, Hosam, additional, Said, Mohammed, additional, Zarzar, Katia, additional, Garcia, Manuel, additional, Türkçapar, Ahmet Gökhan, additional, Şen, Ozan, additional, Baldini, Edoardo, additional, Conti, Luigi, additional, Wietzycoski, Cacio, additional, Lopes, Eduardo, additional, Pintar, Tadeja, additional, Salobir, Jure, additional, Aydin, Cengiz, additional, Atici, Semra Demirli, additional, Ergin, Anıl, additional, Ciyiltepe, Huseyin, additional, Bozkurt, Mehmet Abdussamet, additional, Kizilkaya, Mehmet Celal, additional, Onalan, Nezihe Berrin Dodur, additional, Binti Ahmad Zuber, Mariana Nabila, additional, Wong, Wei Jin, additional, Garcia, Amador, additional, Vidal, Laura, additional, Beisani, Marc, additional, Pasquier, Jorge, additional, Vilallonga, Ramon, additional, Sharma, Sharad, additional, Parmar, Chetan, additional, Lee, Lyndcie, additional, Sufi, Pratik, additional, Sinan, Hüseyin, additional, and Saydam, Mehmet, additional

Published
2022
Full Text
View/download PDF

43. Acetylation reprograms MITF target selectivity

Author

Goding, Colin, primary, Louphrasitthiphol, Pakavarin, additional, Loffreda, Alessia, additional, Pogenberg, Vivian, additional, Picaud, Sarah, additional, Schepsky, Alex, additional, Friedrichsen, Hans, additional, Zeng, Zhiqiang, additional, Thomas, Benjamin, additional, Patton, E, additional, Wilmanns, Matthias, additional, Filippakopoulos, Panagis, additional, Steingrimsson, Eirikur, additional, and Mazza, Davide, additional

Published
2022
Full Text
View/download PDF

48. Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease

Author

Biavasco, Riccardo, primary, Molteni, Raffaella, additional, Stefanoni, Davide, additional, Nemkov, Travis, additional, Netea, Mihai G., additional, Domínguez-Andrés, Jorge, additional, Arts, Rob JW, additional, Merelli, Ivan, additional, Mazza, Davide, additional, Zambrano, Samuel, additional, Panigada, Maddalena, additional, Cantoni, Eleonora, additional, Tengesdal, Isak, additional, Maksud, Philippe, additional, Piras, Francesco, additional, De Luca, Giacomo, additional, Cassina, Laura, additional, Distefano, Gianfranco, additional, Loffreda, Alessia, additional, Gnani, Daniela, additional, Doglioni, Claudio, additional, Tomelleri, Alessandro, additional, Campochiaro, Corrado, additional, Joosten, Leo, additional, Dinarello, Charles A, additional, Kajaste-Rudnitski, Anna, additional, Haroche, Julien, additional, Cardaci, Simone, additional, Cenci, Simone, additional, Dagna, Lorenzo, additional, Ferrarini, Marina, additional, Ferrero, Elisabetta, additional, Boletta, Alessandra, additional, D'Alessandro, Angelo, additional, Montini, Eugenio, additional, and Cavalli, Giulio, additional

Published
2021
Full Text
View/download PDF

49. 99mTc-Radiolabeled Silica Nanocarriers for Targeted Detection and Treatment of HER2-Positive Breast Cancer

Author

Rainone,Paolo, De Palma,Antonella, Sudati,Francesco, Roffia,Valentina, Rigamonti,Valentina, Salvioni,Lucia, Colombo,Miriam, Ripamonti,Marilena, Spinelli,Antonello Enrico, Mazza,Davide, Mauri,Pierluigi, Moresco,Rosa Maria, Prosperi,Davide, Belloli,Sara, Rainone,Paolo, De Palma,Antonella, Sudati,Francesco, Roffia,Valentina, Rigamonti,Valentina, Salvioni,Lucia, Colombo,Miriam, Ripamonti,Marilena, Spinelli,Antonello Enrico, Mazza,Davide, Mauri,Pierluigi, Moresco,Rosa Maria, Prosperi,Davide, and Belloli,Sara

Abstract

Paolo Rainone,1– 3 Antonella De Palma,4 Francesco Sudati,5 Valentina Roffia,4 Valentina Rigamonti,6 Lucia Salvioni,6 Miriam Colombo,6 Marilena Ripamonti,2 Antonello Enrico Spinelli,7 Davide Mazza,7 Pierluigi Mauri,4 Rosa Maria Moresco,1,2,7 Davide Prosperi,6 Sara Belloli2,7 1Department of Medicine and Surgery, University of Milano-Bicocca, Monza, 20900, Italy; 2Institute of Molecular Bioimaging and Physiology of CNR, Segrate, 20090, Italy; 3Doctorate School of Molecular and Translational Medicine, University of Milan, Milan, Italy; 4Institute of Biomedical Technologies of CNR, Segrate, 20090, Italy; 5PET and Nuclear Medicine Unit, San Raffaele Scientific Institute, Milan, 20132, Italy; 6NanoBioLab, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, 20126, Italy; 7Experimental Imaging Center, San Raffaele Scientific Institute, Milan, 20132, ItalyCorrespondence: Sara BelloliInstitute of Molecular Bioimaging and Physiology of CNR, Via Fratelli Cervi 93, Segrate, 20090, ItalyTel +39 02 26433640Fax +39 02 26432717Email belloli.sara@hsr.itIntroduction: The overexpression of Human Epidermal Growth Factor Receptor 2 (HER2) is usually associated with aggressive and infiltrating breast cancer (BC) phenotype, and metastases. Functionalized silica-based nanocarriers (SiNPs) can be labeled for in vivo imaging applications and loaded with chemotherapy drugs, making possible the simultaneous noninvasive diagnosis and treatment (theranostic) for HER2-positive BC.Methods: Firstly, FITC-filled SiNPs, were engineered with two different amounts of Hc-TZ (trastuzumab half-chain) per single nanoparticle (1:2 and 1:8, SiNPs to Hc-TZ ratio), which was 99mTc-radiolabeled at histidine residues for ex vivo and in vivo biodistribution evaluations. Secondly, nanoparticles were loaded with DOX and their in vitro and ex vivo/in vivo delivery was assessed, in comparison with liposomal Doxorubicin (Caelyx). Finally, the treatment efficacy of DOX-SiNPs-TZ (1

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results