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6. Antimicrobial stewardship perspectives from a New York City hospital during the COVID-19 pandemic: Challenges and opportunities

Author

Kubin, Christine J, primary, Loo, Angela S, additional, Cheng, Jennifer, additional, Nelson, Brian, additional, Mehta, Monica, additional, Mazur, Shawn, additional, So, Wonhee, additional, Calfee, David P, additional, Singh, Harjot K, additional, Greendyke, William G, additional, Simon, Matthew S, additional, and Furuya, E Yoko, additional

Published
2021
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7. Compassionate Use of Remdesivir in Pregnant Women With Severe Coronavirus Disease 2019

Author

Burwick, Richard M, primary, Yawetz, Sigal, additional, Stephenson, Kathryn E, additional, Collier, Ai-Ris Y, additional, Sen, Pritha, additional, Blackburn, Brian G, additional, Kojic, E Milunka, additional, Hirshberg, Adi, additional, Suarez, Jose F, additional, Sobieszczyk, Magdalena E, additional, Marks, Kristen M, additional, Mazur, Shawn, additional, Big, Cecilia, additional, Manuel, Oriol, additional, Morlin, Gregory, additional, Rose, Suzanne J, additional, Naqvi, Mariam, additional, Goldfarb, Ilona T, additional, DeZure, Adam, additional, Telep, Laura, additional, Tan, Susanna K, additional, Zhao, Yang, additional, Hahambis, Tom, additional, Hindman, Jason, additional, Chokkalingam, Anand P, additional, Carter, Christoph, additional, Das, Moupali, additional, Osinusi, Anu O, additional, Brainard, Diana M, additional, Varughese, Tilly A, additional, Kovalenko, Olga, additional, Sims, Matthew D, additional, Desai, Samit, additional, Swamy, Geeta, additional, Sheffield, Jeanne S, additional, Zash, Rebecca, additional, and Short, William R, additional

Published
2020
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9. Compassionate Use of Remdesivir in Pregnant Women With Severe Coronavirus Disease 2019.

Author

Burwick, Richard M, Yawetz, Sigal, Stephenson, Kathryn E, Collier, Ai-Ris Y, Sen, Pritha, Blackburn, Brian G, Kojic, E Milunka, Hirshberg, Adi, Suarez, Jose F, Sobieszczyk, Magdalena E, Marks, Kristen M, Mazur, Shawn, Big, Cecilia, Manuel, Oriol, Morlin, Gregory, Rose, Suzanne J, Naqvi, Mariam, Goldfarb, Ilona T, DeZure, Adam, and Telep, Laura

Subjects
COVID-19, INTRAVENOUS therapy, CONVALESCENCE, ANTIVIRAL agents, PREGNANT women, OXYGEN saturation, TREATMENT effectiveness, COMPASSION, ARTIFICIAL respiration, POLYMERASE chain reaction, EVALUATION, PREGNANCY
Abstract

Background Remdesivir is efficacious for severe coronavirus disease 2019 (COVID-19) in adults, but data in pregnant women are limited. We describe outcomes in the first 86 pregnant women with severe COVID-19 who were treated with remdesivir. Methods The reported data span 21 March to 16 June 2020 for hospitalized pregnant women with polymerase chain reaction–confirmed severe acute respiratory syndrome coronavirus 2 infection and room air oxygen saturation ≤94% whose clinicians requested remdesivir through the compassionate use program. The intended remdesivir treatment course was 10 days (200 mg on day 1, followed by 100 mg for days 2–10, given intravenously). Results Nineteen of 86 women delivered before their first dose and were reclassified as immediate "postpartum" (median postpartum day 1 [range, 0–3]). At baseline, 40% of pregnant women (median gestational age, 28 weeks) required invasive ventilation, in contrast to 95% of postpartum women (median gestational age at delivery 30 weeks). By day 28 of follow-up, the level of oxygen requirement decreased in 96% and 89% of pregnant and postpartum women, respectively. Among pregnant women, 93% of those on mechanical ventilation were extubated, 93% recovered, and 90% were discharged. Among postpartum women, 89% were extubated, 89% recovered, and 84% were discharged. Remdesivir was well tolerated, with a low incidence of serious adverse events (AEs) (16%). Most AEs were related to pregnancy and underlying disease; most laboratory abnormalities were grade 1 or 2. There was 1 maternal death attributed to underlying disease and no neonatal deaths. Conclusions Among 86 pregnant and postpartum women with severe COVID-19 who received compassionate-use remdesivir, recovery rates were high, with a low rate of serious AEs. [ABSTRACT FROM AUTHOR]

Published
2021
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11. Real-world implementation and impact of a rapid carbapenemase detection test in an area endemic for carbapenem-resistant Enterobacterales

Author

Trzebucki, Alex M., Westblade, Lars F., Loo, Angela, Mazur, Shawn, Jenkins, Stephen G., Calfee, David P., Satlin, Michael J., and Simon, Matthew S.

Abstract

AbstractA retrospective study was conducted to describe the impact of a molecular assay to detect the most common carbapenemase genes in carbapenem-resistant Enterobacterales isolates recovered in culture. Carbapenemases were detected in 69% of isolates, and assay results guided treatment modifications or epidemiologic investigation in 20% and 4% of cases, respectively.

Published
2022
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12. A Hospitalist-Led Initiative to Promote Antibiotic Citizenship on Internal Medicine Teaching Services

Author

Tang, Stephanie, primary, Gupta, Renuka, additional, Majid, Adrian, additional, Patel, Parimal, additional, Park, Elizabeth, additional, Boas, Rebecca, additional, Efird, Leigh, additional, Loo, Angela, additional, Mazur, Shawn, additional, Kochhar, Savira, additional, Archambault, Alexi, additional, Evans, Arthur, additional, Calfee, David P, additional, Lee, Jennifer, additional, and Simon, Matthew S, additional

Published
2017
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