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In this article, a biomechanical model is presented for dynamic instability behavior of aorta arteries with atherosclerosis conveying pulsating blood including pharmaceutical nanoparticles. Utilizing Mindlin theory of cylindrical shell, the aorta artery is simulated mathematically. The atherosclerosis is assumed symmetric with lipid tissue. The pharmaceutical nanoparticles are subjected to magnetic field for attract to the lipid tissue in artery. Applying energy method and numerical method of differential quadrature (DQ), the final equations are solved for obtaining the dynamic instability region (DIR). The DIR is curve of dynamic blood velocity with respect to artery frequency. The influences of various variables of magnetic field, magnetic nanoparticle's volume percent, tissue, lipid's height and length upon dynamic behavior of aorta artery are investigated. Based on the results, the existence of magnetic nanoparticle in the blood enhances the artery frequency and consequently can lead to better heart performance and reduce the risk of heart attack. [ABSTRACT FROM AUTHOR]

Background: Improving the quality of life (QOL), as the most important goal of therapeutic interventions, is considered in the chronic diseases. This study aimed to evaluate the outcomes of different treatments on QOL in patients with acute coronary syndrome. Materials and Methods: This cohort study was performed, using the convenience sampling, on 167 patients hospitalized with acute coronary syndrome in Kashan Shahid-Beheshti hospital during 2013-2014. Under the supervision of a cardiologist and based on the standard protolab, the QOL of the patients who were received a drug therapy, angioplasty or bypass graft was evaluated before and two months after receiving the treatments using the short form-36 (SF-36) tools. Results: One-hundred and sixty-seven patients (mean age, 56.5± 10.22) were studied. Among them 50.3% were female. Angioplasty and drug therapy had positive effects on the mental health and bodily pain dimensions and increased the total score for QOL. Moreover, drug therapy had a positive impact on the social activity dimension (P=0.01). Coronary artery bypass graft improved the role playing dimension (P=0.005). No significant difference was found in QOL among the three groups: drug therapy; angioplasty and coronary artery bypass graft (P=0.67). Conclusion: Different therapeutic interventions improve the QOL in the acute coronary syndrome and can have a positive effect on some life dimensions of patients. [ABSTRACT FROM AUTHOR]

In medicine field, dynamic investigation of aorta artery has received attention due to its notable functions and significance upon performance of heart and individual health. Because, aortic injuries cause lethal occurrences having numerous mortality rates. Therefore, more probes, in particular, dynamic response of aorta arteries conveying blood flow containing pharmaceutical nanoparticles is essential. In present research, we attempt to model biomechanically the dynamic instability assessment of aorta arteries with atherosclerosis in tissue matrix conveying blood including pharmaceutical magnetic nanoparticles. Thus, according to classical cylindrical shell theory, the aorta arteries will be considered as elastic cylindrical vessels and symmetric lipid tissue is utilized in order to model atherosclerosis in the artery. Applying magnetic field to nanoparticles results in attraction of lipid tissue in artery. Moreover, the nature of blood flow is regarded non-Newtonian based on Casson, Carreau, and power law models. Using Hamilton's principle, the motion equations are derived and based on differential quadrature method, the dynamic instability region of aorta artery is obtained. The influences of different variables such as magnetic field, magnetic nanoparticle's volume percent, combined effects of the tissue, lipid's height and length, and non-Newtonian models upon dynamic behavior of aorta artery are investigated. According to the results, increase in lipid's height leads to increase in resonance frequency of aorta arteries., (© 2021 John Wiley & Sons Ltd.)