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In Germany, the standard format for exchange of clinical care data for research is HL7 FHIR. Graph databases (GDBs), well suited for integrating complex and heterogeneous data from diverse sources, are currently gaining traction in the medical field. They provide a versatile framework for data analysis which is generally challenging for raw FHIR-formatted data. For generation of a knowledge graph (KG) for clinical research data, we tested different extract-transform-load (ETL) approaches to convert FHIR into graph format. We designed a generalised ETL process and implemented a prototypic pipeline for automated KG creation and ontological structuring. The MeDaX-KG prototype is built from synthetic patient data and currently serves internal testing purposes. The presented approach is easy to customise to expand to other data types and formats.