Search

Your search keyword '"Mazaki-Tovi S"' showing total 381 results
Start Over Author "Mazaki-Tovi S"

Refine your results

more »

more »

more »
381 results on '"Mazaki-Tovi S"'

4. Congenital hypotonia: systematic approach for the antenatal detection of an elusive condition

Author

Weissbach, T., primary, Hausman‐Kedem, M., additional, Yanay, Z., additional, Meyer, R., additional, Bar‐Yosef, O., additional, Leibovitch, L., additional, Berkenstadt, M., additional, Chorin, O., additional, Shani, H., additional, Massarwa, A., additional, Achiron, R., additional, Weisz, B., additional, Sharon, R., additional, Mazaki‐Tovi, S., additional, and Kassif, E., additional

Published
2023
Full Text
View/download PDF

5. Congenital hypotonia: systematic approach for prenatal detection.

Author

Weissbach, T., Hausman‐Kedem, M., Yanay, Z., Meyer, R., Bar‐Yosef, O., Leibovitch, L., Berkenstadt, M., Chorin, O., Shani, H., Massarwa, A., Achiron, R., Weisz, B., Sharon, R., Mazaki‐Tovi, S., and Kassif, E.

Subjects
POLYHYDRAMNIOS, NEMALINE myopathy, FETAL MRI, FETAL growth retardation, FETAL movement, BREECH delivery, GENETIC disorder diagnosis
Abstract

Objectives: Congenital hypotonic conditions are rare and heterogeneous, and some are severely debilitating or lethal. Contrary to its prominent postnatal manifestation, the prenatal presentation of hypotonia is frequently subtle, inhibiting prenatal detection. We aimed to characterize the prenatal sonographic manifestation of congenital hypotonia throughout pregnancy, evaluate the yield of diagnostic tests and propose diagnostic models to increase its prenatal detection. Methods: This was a retrospective observational study of singleton pregnancies with congenital hypotonia, diagnosed either prenatally or immediately after birth, at a single tertiary center between the years 2012 and 2020. Prenatally, hypotonia was diagnosed if a fetus showed sonographic or clinical signs suggestive of hypotonia and had a confirmed underlying genetic condition, or in the absence of a known genetic abnormality if the fetus exhibited multiple prominent signs suggestive of hypotonia. Postnatally, it was diagnosed in neonates displaying reduced muscle tone leading to reduced spontaneous movement, reduced swallowing or feeding difficulty. We reviewed the medical records of pregnant patients carrying fetuses subsequently diagnosed with congenital hypotonia and assessed the yield of ultrasound scans, fetal magnetic resonance imaging, computed tomography and genetic tests. The detection rate of sonographic signs suggesting fetal hypotonia was calculated. The prevalence of non‐specific signs, including polyhydramnios, persistent breech presentation, intrauterine growth restriction and maternal perception of reduced fetal movement, were compared between the study group and the local liveborn singleton population. Potential detection rates of different theoretical semiotic diagnostic models, differing in the threshold for referral for a targeted scan, were assessed based on the cohort's data. Results: The study group comprised 26 cases of congenital hypotonia, of which 10 (38.5%) were diagnosed prenatally, and the controls included 95 105 singleton live births, giving a prevalence of congenital hypotonia of 1:3658. Nuchal translucency thickness and the early anomaly scan at 13–17 weeks were normal in all 22 and 23 cases, respectively, in which this was performed. The mid‐trimester scan performed at 19–25 weeks was abnormal in four of 24 (16.7%) cases. The overall prenatal detection rate of congenital hypotonic conditions in our cohort was 38.5%. Only cases which underwent a targeted scan were detected and, among the 16 cases which underwent this scan, the prenatal detection rate was 62.5% compared with 0% in pregnancies that did not undergo this scan (P = 0.003). An abnormal genetic diagnosis was obtained in 21 (80.8%) cases using the following modalities: chromosomal microarray analysis (CMA) in two (9.5%), whole‐exome sequencing (WES) in 14 (66.7%) and methylation analysis in five (23.8%). CMA was abnormal in 8% (2/25) of the cases and WES detected a causative genetic mutation in 87.5% (14/16) of the cases in which these were performed. Comparison of non‐specific signs in the study group with those in the local singleton population showed that hypotonic fetuses had significantly more polyhydramnios (64.0% vs 3.0%, P < 0.0001), persistent breech presentation (58.3% vs 4.2%, P < 0.0001), intrauterine growth restriction (30.8% vs 3.0%, P < 0.0001) and maternal perception of reduced fetal movement (32.0% vs 4.7%, P < 0.0001). Prenatally, the most commonly detected signs supporting a diagnosis of hypotonia were structural anomaly (62.5%, 10/16), reduced fetal movement (46.7%, 7/15), joint contractures (46.7%, 7/15) and undescended testes ≥ 30 weeks (42.9%, 3/7 males). Proposed diagnostic strategies that involved performing a targeted scan for a single non‐specific ultrasound sign or two such signs, and then carrying out a comprehensive genetic evaluation for any additional sign, offered theoretical detection rates in our cohort of 88.5% and 57.7%, respectively. Conclusions: Congenital hypotonic conditions are rare and infrequently detected prenatally. Sonographic signs are visible from the late second trimester. A targeted scan increases prenatal detection significantly. Comprehensive genetic testing, especially WES, is the cornerstone of diagnosis in congenital hypotonia. Theoretical diagnostic models which may increase prenatal detection are provided. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

8. OC01.04: Determination of the normal fetal conus medullaris level throughout pregnancy by a novel three‐dimensional rendering technique

Author

Kassif, E., primary, Weissbach, T., additional, Kivilevitch, Z., additional, Hadi, E., additional, Yulzari, V., additional, Weisz, B., additional, Katorza, E., additional, Messing, B., additional, Yoeli‐Ullman, R., additional, Mazaki‐Tovi, S., additional, Achiron, R., additional, and Adamo, L., additional

Published
2021
Full Text
View/download PDF

9. VP10.04: Clinical and neurodevelopmental outcome of prenatally diagnosed wormian bones

Author

Weissbach, T., primary, Gabis, L., additional, Peretz‐Machluf, R., additional, Cin, R., additional, Pekar, M., additional, Shapira, M., additional, Lev, S., additional, Miller, T. Elkan, additional, Spira, M., additional, Leon‐Attia, O., additional, Shaham, M., additional, Weissbach, A., additional, Achiron, R., additional, Mazaki‐Tovi, S., additional, Weisz, B., additional, and Kassif, E., additional

Published
2021
Full Text
View/download PDF

10. VP20.05: Umbilico‐porto‐systemic shunt and fetal growth restriction: a novel etiology or guilty by association? A lesson from a prospective study

Author

Czeiger, S., primary, Weissbach, T., additional, Zloto, K., additional, Nir, O., additional, Massarwa, A., additional, Abdelkader, R., additional, Weissmann‐Brenner, A., additional, Bartal, M. Fishel, additional, Miller, T. Elkan, additional, Messing, B., additional, Hadi, E., additional, Spira, M., additional, Weisz, B., additional, Yinon, Y., additional, Yoeli‐Ullman, R., additional, Mazaki‐Tovi, S., additional, Kivilevitch, Z., additional, Achiron, R., additional, and Kassif, E., additional

Published
2021
Full Text
View/download PDF

21. Cephalic extraction versus breech extraction in second-stage caesarean section: a retrospective study.

Author

Ezra, O, Lahav‐Ezra, H, Meyer, R, Cahan, T, Ilan, H, Mazaki‐Tovi, S, Sivan, E, Barzilay, E, Haas, J, Lahav-Ezra, H, and Mazaki-Tovi, S

Subjects
CESAREAN section, BLOOD transfusion, RETROSPECTIVE studies, APGAR score, SUBGROUP analysis (Experimental design), BREECH delivery, SECOND stage of labor (Obstetrics), LONGITUDINAL method
Abstract

Objective: Our primary objective was to compare maternal and neonatal outcomes based on the attempted mode of extraction. Our secondary objective was to compare the outcomes based on the actual mode of extraction.Design: A retrospective cohort study at a single tertiary centre between the years 2011 and 2019.Setting: The study included 1028 cases of term pregnancies in vertex presentation that were delivered by caesarean section at the second stage of delivery.Population: Patients were grouped according to the attempted mode of extraction: attempted cephalic extraction (674) and breech extraction (354). A subgroup analysis was conducted, comparing successful cephalic extraction (615), failed cephalic extraction (59) and breech extraction (354).Methods: Both maternal and neonatal complication rates were compared between the groups.Results: There were significantly more uterine incision extensions (27.4 versus 11.9%, P < 0.001) and increased need for blood transfusion (10.7 versus 6.2%, P = 0.018) in the cephalic extraction compared with the breech extraction group. The highest rate of uterine incision extensions (45.8%) and need for blood transfusion (22%) was in the subgroup of failed cephalic extraction. The rate of adverse neonatal outcomes was comparable between the two groups. However, in the subgroup of failed cephalic extraction, there were higher rates of low 1-minute Apgar scores, NICU hospitalisation and limb fractures compared with successful cephalic extractions and breech extractions (P = 0.016, 0.01, <0.001, respectively).Conclusions: Breech extraction in second-stage caesarean section is associated with fewer maternal complications compared wiith attempted cephalic extraction without increasing neonatal complication rates.Tweetable Abstract: In breech versus cephalic extraction, breech extraction was found to have better outcomes in second-stage caesarean section. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

36. Current debate on the use of antibiotic prophylaxis for caesarean section

Author

Lamont, R F, Sobel, J D, Kusanovic, J P, Vaisbuch, E, Mazaki-Tovi, S, Kim, S K, Uldbjerg, Niels, and Romero, R

Abstract

Caesarean delivery is frequently complicated by surgical site infections, endometritis and urinary tract infection. Most surgical site infections occur after discharge from the hospital, and are increasingly being used as performance indicators. Worldwide, the rate of caesarean delivery is increasing. Evidence-based guidelines recommended the use of prophylactic antibiotics before surgical incision. An exception is made for caesarean delivery, where narrow-range antibiotics are administered after umbilical cord clamping because of putative neonatal benefit. However, recent evidence supports the use of pre-incision, broad-spectrum antibiotics, which result in a lower rate of maternal morbidity with no disadvantage to the neonate.

Published
2011

37. Parvovirus B19 infection in human pregnancy

Author

Lamont, R F, Sobel, J D, Vaisbuch, E, Kusanovic, J P, Mazaki-Tovi, S, Kim, S K, Uldbjerg, Niels, and Romero, R

Abstract

Human parvovirus B19 infection is widespread. Approximately 30-50% of pregnant women are nonimmune, and vertical transmission is common following maternal infection in pregnancy. Fetal infection may be associated with a normal outcome, but fetal death may also occur without ultrasound evidence of infectious sequelae. B19 infection should be considered in any case of nonimmune hydrops. Diagnosis is mainly through serology and polymerase chain reaction. Surveillance requires sequential ultrasound and Doppler screening for signs of fetal anaemia, heart failure and hydrops. Immunoglobulins, antiviral and vaccination are not yet available, but intrauterine transfusion in selected cases can be life saving.

Published
2011

39. Adiponectin Multimers in Normal Pregnancy

Author

MAZAKI-TOVI, S., ROMERO, R., KUSANOVIC, J.P., EREZ, O., VAISBUCH, E., GOTSCH, F., MITTAL, P., THAN, N. G., NHAN-CHANG, C.L., CHAIWORAPONGSA, T., EDWIN, S., CAMACHO, N., GOMEZ, R., NIEN, J.K., and HASSAN, S.S.

Subjects
Adult, Young Adult, Cross-Sectional Studies, Labor, Obstetric, Pregnancy, Term Birth, Humans, Protein Isoforms, Female, Adiponectin, Overweight, Article, Body Mass Index
Abstract

Adiponectin is an anti-diabetic, anti-atherogenic, anti-inflammatory, and angiogenic adipokine that circulates in oligomeric complexes including: low molecular weight (LMW) trimers, medium molecular weight (MMW) hexamers, and high molecular weight (HMW) isoforms. The aim of this study was to determine whether there are changes in adiponectin multimers in pregnancy and as a function of maternal weight.In this cross-sectional study, plasma concentrations of total, HMW, MMW, and LMW adiponectin were determined in women included in three groups: (1) normal pregnant women of normal body mass index (BMI) (n = 466), (2) overweight pregnant women (BMIor=25; n = 257), and (3) non-pregnant women of normal weight (n = 40). Blood samples were collected once from each woman between 11 and 42 weeks of gestation. Plasma adiponectin multimer concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Non-parametric statistics were used for analysis.(1) The median HMW adiponectin concentration and the median HMW/total adiponectin ratio were significantly higher, and the median LMW adiponectin concentration was significantly lower in pregnant women than in non-pregnant women. (2) Among pregnant women, the median plasma concentration of total, HMW, and MMW adiponectin was significantly higher in normal weight women than in overweight patients. (3) Maternal HMW was the most prevalent adiponectin multimer regardless of gestational age or BMI status. (4) There were no significant differences in the median concentration of total, MMW, and LMW adiponectin and their relative distribution with advancing gestation.Human pregnancy is characterized by quantitative and qualitative changes in adiponectin multimers, especially the most active isoform, HMW adiponectin.

Published
2008

40. Choosing between bad, worse and worst: what is the preferred mode of delivery for failure of the second stage of labor?.

Author

Hendler, I., Kirshenbaum, M., Barg, M., Kees, S., Mazaki-Tovi, S., Moran, O., Kalter, A., and Schiff, E.

Subjects
DELIVERY (Obstetrics), DYSTOCIA, LABOR complications (Obstetrics), CESAREAN section, PREGNANCY complications, COMPARATIVE studies, INFECTION, LABOR (Obstetrics), LONGITUDINAL method, RESEARCH methodology, EVALUATION of medical care, MEDICAL cooperation, OBSTETRICAL extraction, OBSTETRICAL forceps, PREGNANCY, PUERPERAL disorders, RESEARCH, EVALUATION research, TREATMENT effectiveness, RETROSPECTIVE studies
Abstract

Objective: To determine the preferred mode of delivery (vacuum, forceps or cesarean delivery) for second-stage dystocia.Methods: Retrospective cohort study of women delivered by forceps, vacuum or cesarean delivery due to abnormalities of the second stage of labor. Primary outcome included neonatal and maternal composite adverse effects.Results: A total of 547 women were included: 150 (27.4%) had forceps delivery, 200 (36.5%) had vacuum extraction, and 197 (36.1%) had cesarean section. The rate of neonatal composite outcome was significantly increased in vacuum extraction (27%) compared to forceps delivery (14.7%) or cesarean section (9.7%) (p < 0.001). There was no difference in the rate of maternal composite outcome among the groups. Both operative vaginal delivery modes were associated with significantly lower rate of postpartum infection compared to cesarean delivery (0% versus 3%, p = 0.004).Conclusion: Operative vaginal delivery was associated with reduced postpartum infection compared to cesarean section. Forceps delivery was associated with reduced risk for adverse neonatal outcome compared to vacuum extraction, with no increase in the risk of composite maternal complications. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

42. Disparity in fetal growth between twin and singleton gestation: the role of adipokines

Author

Zemet, R, Shulman, Y, Hemi, R, Brandt, B, Sivan, E, Kanety, H, and Mazaki-Tovi, S

Abstract

Objective:Twin pregnancies are characterized by unique pattern of attenuated fetal weight gain during late gestation compared with singleton gestation. The mechanism(s) responsible for regulating twin growth has not yet elucidated. Leptin and adiponectin are two adipocytokines implicated in metabolism and energy balance of fetuses, newborns and adults. Moreover, these hormones have been suggested to play a role in fetal growth. The objective of the study was to determine cord blood adiponectin and leptin in twins and singletons, with and without growth impairment.Study design:This was a case-control study. It included two groups of newborns, matched for gestational age and birth weight percentile: singleton (n=60 newborns) and twins (n=44 newborns). Adiponectin and leptin were determined in cord blood, and compared between the groups according to clinical and demographic characteristics. Non-parametric and parametric statistical methods were employed.Results:Median adiponectin and leptin concentrations were lower in twins vs singletons (P<0.001 for both comparisons). Among small for gestational age newborns (SGA), median concentration of adiponectin (P=0.04), but not leptin (P=0.1), was lower in twins compared to singletons. In pooled analysis (singleton plus twins), cord blood adiponectin and leptin were strongly correlated with gestational age (P<0.001 and P=0.005, respectively) and birth weight (P<0.001 and P<0.001, respectively). Regression analysis revealed that plurality (P=0.02) was significantly and independently associated with cord blood adiponectin concentrations, after adjustment for confounding variables. Similar regression in which leptin was the independent variable revealed that only birth weight (P=0.01) was significantly and independently associated with cord blood leptin concentrations.Conclusions:Twin pregnancies are associated with lower cord blood concentrations of adiponectin and leptin compared with singleton gestations. However, only cord blood adiponectin, but not leptin, was lower in SGA neonates. Collectively, these data suggest that adiponectin may be implicated in the mechanism accounting for the growth disparity between twins and singletons.

Published
2018
Full Text
View/download PDF

46. OP14.05: A link between an anti-angiogenic state in the first trimester and abnormal uterine artery Doppler in the midtrimester

Author

Chaiworapongsa, T., primary, Romero, R., additional, Kusanovic, J., additional, Mazaki-Tovi, S., additional, Gotsch, F., additional, Erez, O., additional, Vaisbuch, E., additional, Mittal, P., additional, Kim, S. K., additional, Nhan-Chang, C. L., additional, Hamill, N., additional, Sorokin, Y., additional, Yeo, L., additional, and Hassan, S., additional

Published
2009
Full Text
View/download PDF

48. OP04.01: The fetal cardiovascular response to an increased placental vascular resistance (PVR) measured with STIC and VOCAL

Author

Hamill, N., primary, Romero, R., additional, Kusanovic, J. P., additional, Vaisbuch, E., additional, Lee, W., additional, Hassan, S., additional, Mittal, P., additional, Chaiworapongsa, T., additional, Myers, S., additional, Gotsch, F., additional, Mazaki-Tovi, S., additional, Erez, O., additional, and Yeo, L., additional

Published
2009
Full Text
View/download PDF

49. OP14.06: Late-onset preeclampsia cannot be identified with either an anti-angiogenic profile in maternal plasma or uterine artery Doppler velocimetry

Author

Chaiworapongsa, T., primary, Romero, R., additional, Kusanovic, J., additional, Vaisbuch, E., additional, Mazaki-Tovi, S., additional, Erez, O., additional, Mittal, P., additional, Kim, S. K., additional, Gotsch, F., additional, Nhan-Chang, C. L., additional, Jodicke, C., additional, Hamill, N., additional, Sorokin, Y., additional, Yeo, L., additional, and Hassan, S., additional

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results