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Social media today has become a very popular communication tool for users. Millions of users share their opinions on different aspects on daily basis. Sentiment Analysis determines the polarity and inclination towards any specific topic, idea or entity. Applications of such analysis can be seen during elections, movie promotions, and many other fields. In our project, we aim to predict the winning probability of any political party by using both labelled as well as unlabeled data. Labelled data can be collected by using polling method but the result may not provide better accuracy. Hence, it is necessary to fetch live data to predict the accurate election result. Twitter is a microblogging site which allows the users in posting quick and real-time updates about different activities or events as the spread of information and news is quick enough. With the help of hashtags, the needed data can be easily generated and put to use. We exploited the python library “Tweepy” for accessing the Twitter API and fetched live data from Twitter. 350 tweets for each political party are fetched by using keywords. Using “TextBlob” library of python, sentiments are applied to each tweet and depending upon more positive tweets for particular party, winning party is declared. Also, popular text classification algorithms like Na¨ıve Bayes, SVM and Random Forest are used to train model using labelled data. The accuracy of the predicted result is calculated and the result is declared Finally, result is represented in the form of bargraph for labelled data according to the number of voted for each political party and for unlabeled data using pie chart for each political party representing positive, negative and neutral sentiments.

Purpose: Vitreoretinal lymphoma (VRL) is the most common intraocular lymphoma (IOL). This can be either primary or secondary to the central nervous system lymphoma. The diagnosis of primary intraocular lymphoma (PIOL) currently relies on clinical diagnosis and cytological analysis of the vitreous or subretinal biopsy. Although most cases are diagnosed without much issue, the limited amount of vitreous fluid, subjectivity in cytological reporting, and special expertise in ocular pathology make the diagnosis challenging. MYD88 L265P mutation has been implicated to have diagnostic utility in PIOL. In this study, we screened consecutive vitreous biopsies for the presence of MYD88 L265P mutation to understand its diagnostic utility compared to conventional cytological analysis. Methods: Cytological analysis and MYD88 L265P mutation by PCR-based sequencing and restriction fragment length polymorphism (RFLP) were carried out on consecutive vitreous and subretinal biopsies collected from 21 patients. The diagnostic utility of the cytology and MYD88 L265P mutation analysis were compared. Results: Out of the 21 patients, 15 had clinical suspicion of having PIOL. Out of these suspected cases of PIOL, nine were confirmed on follow-up, while six were diagnosed as other intraocular pathologies. Diagnostic utility of MYD88 L265P mutation analysis revealed a sensitivity of 88.9%, specificity of 91.6%, positive and negative predictive value of 88.9% and 91.7%, respectively. Diagnostic accuracy of 90.5% was achieved with the mutation analysis that shows the superiority of MYD88 in both ruling in and ruling out PIOL. The diagnostic utility of MYD88 L265P mutation was superior to conventional cytological analysis. Conclusion: The analysis of MYD88 L265P mutation is reliable and efficient in the diagnosis of PIOL.

Retinoblastoma (RB) is a childhood eye tumor, caused by the RB1 gene mutation. Since RB is a rapidly proliferating tumor, the patient presents with a Group-D/E tumor at the time of diagnosis. Enucleation is preferred in most unilateral cases to prevent metastasis. Various cell lines have been established to study the tumor's growth pattern and target the cancer cells. The commonly used cell lines are WERI-Rb-1 and Y79, both isolated from the primary tumor of RB. Cell lines established from the metastatic site of RB have not been characterized before. In this study, we have characterized NCC-RbC-51, derived from RB tumor to cervical lymph node site and investigated its potential to represent a highly aggressive and metastatic tumor. We compared the proliferative and invasive properties of NCC-RbC-51 with a cell line isolated from the primary site, WERI-Rb-1. NCC-RbC-51 had higher rates of proliferation and apoptosis and had better invasive ability. Copy number variation analysis and the pathways predicted from these show that the pathways altered in NCC-RbC-51 could contribute to its metastatic nature. In all, the results suggest that NCC-RbC-51, a cell line isolated from metastatic site, could be a potential model to study aggressive/invasive RB.

Introduction: Ganglion cysts are benign soft tissue swellings commonly found in the wrist. The presence of these cysts in the elbow is uncommon, and few case reports have been reported for this condition at this location. These lesions can compress on the neighbouring structures or cause restriction of the joint movement. The awareness of this entity is a must, to arrive at an early diagnosis. Materials and Method: We report a patient with swelling in the anterolateral aspect of the elbow which had been causing intermittent pain for the last 13 months. The MRI revealed a multilobulated complex cystic lesion along ulnar aspect of distal arm. Results: The lesion was excised in toto, using anterolateral approach for the elbow, and sent for histopathological examination which confirmed the diagnosis of a ganglion cyst. Conclusion: Thus, due to the infrequent presentation, an awareness of this condition is necessary to prevent a delay in diagnosis and its subsequent management.

Background: Rotator cuff abnormalities (including degenerative tears and those due to injury) reportedly account for up to 70% of symptoms associated with the shoulder and have significant effects on quality of life and activities of daily living. Material and Method: The objective of this study was to compare the use of resources, costs and health-related quality of life outcomes associated with arthroscopic and mini open surgical management of rotator cuff tears using follow-up of 2 years data from retrospectively and prospectively.The study was conducted at Pravara Rural Hospital, an associate hospital of Rural Medical Collage Loni during the period of 2016 to 2018.Results: There are total 125 patient’s data collected by retrospectively and prospectively. Among them 60 patient underwent mini open repair and 65 patient underwent arthroscopic repair of rotator cuff tear. There were, 41 % female patient and 59 % male patient in mini open repair, 53% female and 57 % male patients in arthroscopic repair.Conclusion: There is no significant difference in the functional outcome in the patient operated with mini open repair and arthroscopic repair.There is a significant difference in patient’s preference for surgery according to cost effectiveness as study conducted in rural area, so cost effectiveness is really matters for the patients coming from a poor background in rural area.

Mean number of pieces of haemostat kit used per cardiac surgical procedure (UK data). Market research data that investigated the average number of haemostat kits used in surgical procedures in the UK. (DOC 44 kb)

Exopolysaccharides (EPS) of fungal origin have attracted special attention from researchers due to their multifarious applications in the food and pharmaceutical industries. In the present study, optimization of the process parameters for the production of exopolysaccharide by Schizophyllum commune AGMJ-1 was studied using one factor at a time (OFAT) method, Plackett–Burman design (PBD) and response surface methodology (RSM). OFAT method revealed xylose and yeast extract to be the most effective carbon and nitrogen sources and pH 5.3 as an optimum for maximum EPS production. Xylose, yeast extract and KCl were screened as statistically significant variables for EPS production using PBD. RSM based on the central composite design estimated that maximum EPS (4.26 g L−1), mycelial biomass (14 g L−1) and specific yield (0.45 g g−1) were obtained when concentration of xylose, yeast extract and KCl were set at 2.5 g % (w/v), 0.83 g % (w/v) and 6.53 mg % (w/v), respectively, in the production medium.