1. Extracellular water to total body water ratio, a novel predictor of recurrence in patients with colorectal cancer
- Author
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Taichi Horino, Ryuma Tokunaga, Yuji Miyamoto, Takahiko Akiyama, Nobuya Daitoku, Yuki Sakamoto, Mayuko Ohuchi, Katsuhiro Ogawa, Naoya Yoshida, and Hideo Baba
- Subjects
colorectal cancer ,extracellular water ,intracellular water ,prognosis ,recurrence ,Surgery ,RD1-811 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background Total body water (TBW) fraction, which accounts for 60% of body weight, is an important indicator of body composition, and the extracellular water to TBW ratio (ECW/TBW) is reportedly useful in predicting clinical outcomes of patients with organ disorders. We aimed to clarify the clinical impact of preoperative ECW/TBW status on survival outcomes in cancer patients. Methods We used a database of 320 colorectal cancer (CRC) patients who underwent potentially curative resections. Preoperative ECW/TBW was measured using a bioelectrical impedance analysis (BIA), and its correlation with patient survival outcomes, clinicopathological factors, laboratory data, and comorbidities were analyzed. Results A high preoperative ECW/TBW was significantly associated with poorer relapse‐free survival (RFS; p = 0.001) and overall survival (OS; p = 0.003). A high ECW/TBW ratio was significantly associated with older age (p
- Published
- 2024
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