1. Antibacterial activity of some 5-dialkylaminomethylhydantoins and related derivatives
- Author
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Keiko Toyofuku, Nobuhiro Kashige, Fumio Miake, Fumiko Fujisaki, Naho Nakamoto, Shiori Ishida, Mayu Egami, and Kunihiro Sumoto
- Subjects
Staphylococcus aureus ,Strain (chemistry) ,Stereochemistry ,Hydantoins ,Hydantoin ,General Chemistry ,General Medicine ,Microbial Sensitivity Tests ,Related derivatives ,medicine.disease_cause ,Anti-Bacterial Agents ,chemistry.chemical_compound ,Structure-Activity Relationship ,Biochemistry ,chemistry ,Drug Discovery ,medicine ,Hydantoin derivatives ,Escherichia coli ,Antibacterial activity - Abstract
In connection with our studies on antibacterial compounds in the class of 5-dialkylaminomethylhydantoins against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) strains, some molecular modifications were attempted. The antibacterial activities of all of the synthesized hydantoin derivatives were evaluated. Among the hydantoin derivatives designed in this study, C₂-symmetrical twin-drug type compound (7) showed the highest level of antibacterial activity against S. aureus strain.
- Published
- 2013