100 results on '"Mayowa Owolabi"'
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2. Challenges and enablers for scaling up interventions targeting non-communicable diseases: a qualitative study applying the Consolidated Framework for Implementation Research to 19 research projects worldwide
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Peter Delobelle, Meena Daivadanam, Hassan Haghparast-Bidgoli, Maria Lazo-Porras, J Jaime Miranda, Rohina Joshi, Rajesh Vedanthan, Gina Agarwal, Kerstin Klipstein-Grobusch, Naomi Levitt, Dike Ojji, Feng J He, Pascal Geldsetzer, Puhong Zhang, Milena Soriano Marcolino, Lal B Rawal, Brian Oldenburg, Helena Teede, Josephine Birungi, Edwin Wouters, Abha Shrestha, Ari Probandari, Mayowa Owolabi, Vilma Irazola, Andrea Beratarrechea, Keiko Nakamura, Gindo Tampubolon, Zulma Ortiz, Violet Naanyu, Jaap Koot, Anusha Ramani-Chander, Stephen Sherwood, Monika Martens, Gade Waqa, Maria Eugenia Esandi, Sujarwoto Sujarwoto, Laura Antonietti, Jan-Walter De Neve, Sayoki G Mfinanga, and Antonio Luiz Pinho Ribeiro
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Public aspects of medicine ,RA1-1270 - Abstract
Introduction Scaling up interventions targeting non-communicable diseases (NCDs) is a global health priority, and implementation research can contribute to that effort. In 2019, the Global Alliance for Chronic Diseases funded 27 implementation research studies to improve evidence for scaling up interventions targeting prevention and/or control of hypertension and/or diabetes in low-resource settings. We examined these studies to improve the understanding of the implementation factors, including challenges and facilitators, that influence the early implementation phase of scale-up research projects targeting NCDs.Methods This qualitative study was undertaken between August 2020 and July 2021. 43 semi-structured interviews were conducted with project investigators, implementers and policymakers, across 19 diverse scale-up projects, being implemented in 20 countries. The transcripts were inductively, open-coded using thematic analysis. Generated themes were mapped systematically to four out of five domain categorisations of the Consolidated Framework for Implementation Research (CFIR); the innovation domain fell outside the scope of this study.Results Highlighted findings using CFIR are: (i) outer setting: influence of politics, lack of coordination between government departments and differing agendas towards NCDs hindered implementation while reliable and trustworthy government connections proved useful; (ii) inner setting: commitment of resources for implementation was a challenge while research capacity, work culture and trustworthy networks facilitated implementation; (iii) individuals: high-level stakeholder support and leadership was essential; (iv) process: extensive time and efforts required for stakeholder engagement towards local contextualisation was challenging, while collaborating, joint reflection, effective communication and adaptation facilitated. COVID-19 provided both challenges and opportunities and these varied depending on the intervention characteristics and study objectives.Conclusion Researchers supporting the scale-up of complex interventions targeting NCDs need to leverage on existing trusting relationships and foster equitable stakeholder partnerships through research. Interpersonal skills and good communication are essential complements to research expertise and must be considered during capacity building.
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- 2024
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3. Interdisciplinary perspectives on multimorbidity in Africa: Developing an expanded conceptual model.
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Justin Dixon, Ben Morton, Misheck J Nkhata, Alan Silman, Ibrahim G Simiyu, Stephen A Spencer, Myrna Van Pinxteren, Christopher Bunn, Claire Calderwood, Clare I R Chandler, Edith Chikumbu, Amelia C Crampin, John R Hurst, Modou Jobe, Andre Pascal Kengne, Naomi S Levitt, Mosa Moshabela, Mayowa Owolabi, Nasheeta Peer, Nozgechi Phiri, Sally J Singh, Tsaone Tamuhla, Mandikudza Tembo, Nicki Tiffin, Eve Worrall, Nateiya M Yongolo, Gift T Banda, Fanuel Bickton, Abbi-Monique Mamani Bilungula, Edna Bosire, Marlen S Chawani, Beatrice Chinoko, Mphatso Chisala, Jonathan Chiwanda, Sarah Drew, Lindsay Farrant, Rashida A Ferrand, Mtisunge Gondwe, Celia L Gregson, Richard Harding, Dan Kajungu, Stephen Kasenda, Winceslaus Katagira, Duncan Kwaitana, Emily Mendenhall, Adwoa Bemah Boamah Mensah, Modai Mnenula, Lovemore Mupaza, Maud Mwakasungula, Wisdom Nakanga, Chiratidzo Ndhlovu, Kennedy Nkhoma, Owen Nkoka, Edwina Addo Opare-Lokko, Jacob Phulusa, Alison Price, Jamie Rylance, Charity Salima, Sangwani Salimu, Joachim Sturmberg, Elizabeth Vale, and Felix Limbani
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Public aspects of medicine ,RA1-1270 - Abstract
Multimorbidity is an emerging challenge for health systems globally. It is commonly defined as the co-occurrence of two or more chronic conditions in one person, but its meaning remains a lively area of academic debate, and the utility of the concept beyond high-income settings is uncertain. This article presents the findings from an interdisciplinary research initiative that drew together 60 academic and applied partners working in 10 African countries to answer the questions: how useful is the concept of multimorbidity within Africa? Can the concept be adapted to context to optimise its transformative potentials? During a three-day concept-building workshop, we investigated how the definition of multimorbidity was understood across diverse disciplinary and regional perspectives, evaluated the utility and limitations of existing concepts and definitions, and considered how to build a more context-sensitive, cross-cutting description of multimorbidity. This iterative process was guided by the principles of grounded theory and involved focus- and whole-group discussions during the workshop, thematic coding of workshop discussions, and further post-workshop development and refinement. Three thematic domains emerged from workshop discussions: the current focus of multimorbidity on constituent diseases; the potential for revised concepts to centre the priorities, needs, and social context of people living with multimorbidity (PLWMM); and the need for revised concepts to respond to varied conceptual priorities amongst stakeholders. These themes fed into the development of an expanded conceptual model that centres the catastrophic impacts multimorbidity can have for PLWMM, families and support structures, service providers, and health systems.
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- 2024
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4. Maintenance of brain health: The role of social determinants of health and other non-traditional cardiovascular risks
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Paul Olowoyo, Olaleye Adeniji, Rufus Akinyemi, and Mayowa Owolabi
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Brain health ,Social determinants ,Non-traditional cardiovascular risks ,Specialties of internal medicine ,RC581-951 ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Brain health is the complete functioning of the brain across the life course to support the full physical, mental, social, and spiritual well-being and quality of life of an individual towards attaining and maintaining the epitome of a meaningful, impactful, purposeful, and productive life. The determinants of brain health are complex and include at least in part, non-traditional risks such as interactions among social, economic, physical, and internal factors (e.g., emotions and adaptations to changing life experiences), and external factors such as environment, geography, and climate change. Thus, social determinants of health (e.g., where we work, live, and play) are those non-medical factors that influence health outcomes, and as non-traditional cardiovascular factors, may influence the development of traditional cardiovascular risks. Examples of the non-traditional cardiovascular factors include environmental stressors (e.g., climate change, air pollution), and psychological and physical abuse. In this article, we provide a discussion of social determinants of health and other non-traditional cardiovascular risks as they relate to brain health.
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- 2024
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5. Estimating vaccine coverage in conflict settings using geospatial methods: a case study in Borno state, Nigeria
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Alyssa N. Sbarra, Sam Rolfe, Emily Haeuser, Jason Q. Nguyen, Aishatu Adamu, Daniel Adeyinka, Olufemi Ajumobi, Chisom Akunna, Ganiyu Amusa, Tukur Dahiru, Michael Ekholuenetale, Christopher Esezobor, Kayode Fowobaje, Simon I. Hay, Charles Ibeneme, Segun Emmanuel Ibitoye, Olayinka Ilesanmi, Gbenga Kayode, Kris Krohn, Stephen S. Lim, Lyla E. Medeiros, Shafiu Mohammed, Vincent Nwatah, Anselm Okoro, Andrew T. Olagunju, Bolajoko O. Olusanya, Osayomwanbo Osarenotor, Mayowa Owolabi, Brandon Pickering, Mu’awiyyah Babale Sufiyan, Benjamin Uzochukwu, Ally Walker, and Jonathan F. Mosser
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Medicine ,Science - Abstract
Abstract Reliable estimates of subnational vaccination coverage are critical to track progress towards global immunisation targets and ensure equitable health outcomes for all children. However, conflict can limit the reliability of coverage estimates from traditional household-based surveys due to an inability to sample in unsafe and insecure areas and increased uncertainty in underlying population estimates. In these situations, model-based geostatistical (MBG) approaches offer alternative coverage estimates for administrative units affected by conflict. We estimated first- and third-dose diphtheria-tetanus-pertussis vaccine coverage in Borno state, Nigeria, using a spatiotemporal MBG modelling approach, then compared these to estimates from recent conflict-affected, household-based surveys. We compared sampling cluster locations from recent household-based surveys to geolocated data on conflict locations and modelled spatial coverage estimates, while also investigating the importance of reliable population estimates when assessing coverage in conflict settings. These results demonstrate that geospatially-modelled coverage estimates can be a valuable additional tool to understand coverage in locations where conflict prevents representative sampling.
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- 2023
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6. Strengthening evidence to inform health systems: opportunities for the WHO and partners to accelerate progress on non-communicable diseases
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J Jaime Miranda, Liming Li, Adnan A Hyder, Salim S Virani, Bente Mikkelsen, Robert Marten, Srinath Reddy, Ishu Kataria, Rachel Nugent, Tiina Laatikainen, Sarah Rylance, Yodi Mahendradhata, Richard Sullivan, Valery Feigin, Valery L Feigin, Mayowa Owolabi, K Srinath Reddy, Abeer Al Saegh, and Liming Lee
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Medicine (General) ,R5-920 ,Infectious and parasitic diseases ,RC109-216 - Published
- 2023
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7. Biological sample donation and informed consent for neurobiobanking: Evidence from a community survey in Ghana and Nigeria.
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Arti Singh, Oyedunni Arulogun, Joshua Akinyemi, Michelle Nichols, Benedict Calys-Tagoe, Babatunde Ojebuyi, Carolyn Jenkins, Reginald Obiako, Albert Akpalu, Fred Sarfo, Kolawole Wahab, Adeniyi Sunday, Lukman F Owolabi, Muyiwa Adigun, Ibukun Afolami, Olorunyomi Olorunsogbon, Mayowa Ogunronbi, Ezinne Sylvia Melikam, Ruth Laryea, Shadrack Asibey, Wisdom Oguike, Lois Melikam, Abdullateef Sule, Musibau A Titiloye, Isah Suleiman Yahaya, Abiodun Bello, Rajesh N Kalaria, Ayodele Jegede, Mayowa Owolabi, Bruce Ovbiagele, and Rufus Akinyemi
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Medicine ,Science - Abstract
IntroductionGenomic research and neurobiobanking are expanding globally. Empirical evidence on the level of awareness and willingness to donate/share biological samples towards the expansion of neurobiobanking in sub-Saharan Africa is lacking.AimsTo ascertain the awareness, perspectives and predictors regarding biological sample donation, sharing and informed consent preferences among community members in Ghana and Nigeria.MethodsA questionnaire cross-sectional survey was conducted among randomly selected community members from seven communities in Ghana and Nigeria.ResultsOf the 1015 respondents with mean age 39.3 years (SD 19.5), about a third had heard of blood donation (37.2%, M: 42.4%, F: 32.0%, p = 0.001) and a quarter were aware of blood sample storage for research (24.5%; M: 29.7%, F: 19.4%, p = 0.151). Two out of ten were willing to donate brain after death (18.8%, M: 22.6%, F: 15.0%, pConclusionThere is a greater need for research attention in the area of brain banking and informed consent. Improved context-sensitive public education on neurobiobanking and informed consent, in line with the sociocultural diversities, is recommended within the African sub region.
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- 2022
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8. The copy number variation and stroke (CaNVAS) risk and outcome study.
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John W Cole, Taiwo Adigun, Rufus Akinyemi, Onoja Matthew Akpa, Steven Bell, Bowang Chen, Jordi Jimenez Conde, Uxue Lazcano Dobao, Israel Fernandez, Myriam Fornage, Cristina Gallego-Fabrega, Christina Jern, Michael Krawczak, Arne Lindgren, Hugh S Markus, Olle Melander, Mayowa Owolabi, Kristina Schlicht, Martin Söderholm, Vinodh Srinivasasainagendra, Carolina Soriano Tárraga, Martin Stenman, Hemant Tiwari, Margaret Corasaniti, Natalie Fecteau, Beth Guizzardi, Haley Lopez, Kevin Nguyen, Brady Gaynor, Timothy O'Connor, O Colin Stine, Steven J Kittner, Patrick McArdle, Braxton D Mitchell, Huichun Xu, and Caspar Grond-Ginsbach
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Medicine ,Science - Abstract
Background and purposeThe role of copy number variation (CNV) variation in stroke susceptibility and outcome has yet to be explored. The Copy Number Variation and Stroke (CaNVAS) Risk and Outcome study addresses this knowledge gap.MethodsOver 24,500 well-phenotyped IS cases, including IS subtypes, and over 43,500 controls have been identified, all with readily available genotyping on GWAS and exome arrays, with case measures of stroke outcome. To evaluate CNV-associated stroke risk and stroke outcome it is planned to: 1) perform Risk Discovery using several analytic approaches to identify CNVs that are associated with the risk of IS and its subtypes, across the age-, sex- and ethnicity-spectrums; 2) perform Risk Replication and Extension to determine whether the identified stroke-associated CNVs replicate in other ethnically diverse datasets and use biomarker data (e.g. methylation, proteomic, RNA, miRNA, etc.) to evaluate how the identified CNVs exert their effects on stroke risk, and lastly; 3) perform outcome-based Replication and Extension analyses of recent findings demonstrating an inverse relationship between CNV burden and stroke outcome at 3 months (mRS), and then determine the key CNV drivers responsible for these associations using existing biomarker data.ResultsThe results of an initial CNV evaluation of 50 samples from each participating dataset are presented demonstrating that the existing GWAS and exome chip data are excellent for the planned CNV analyses. Further, some samples will require additional considerations for analysis, however such samples can readily be identified, as demonstrated by a sample demonstrating clonal mosaicism.ConclusionThe CaNVAS study will cost-effectively leverage the numerous advantages of using existing case-control data sets, exploring the relationships between CNV and IS and its subtypes, and outcome at 3 months, in both men and women, in those of African and European-Caucasian descent, this, across the entire adult-age spectrum.
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- 2021
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9. Association between white matter hyperintensities and stroke in a West African patient population: Evidence from the Stroke Investigative Research and Educational Network study
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Jingfei Li, Godwin Ogbole, Benjamin Aribisala, Murtala Affini, Joseph Yaria, Issa Kehinde, Mukaila Rahman, Fakunle Adekunle, Rasaq Banjo, Moyinoluwalogo Faniyan, Rufus Akinyemi, Bruce Ovbiagele, Mayowa Owolabi, and Steffen Sammet
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Stroke ,West Africa ,Magnetic resonance imaging (MRI) ,Lesion segmentation ,White matter hyperintensity ,SIREN ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background: This study is part of the Stroke Investigative Research and Educational Network (SIREN), the largest study of stroke patients in Africa to date, with computed tomography (CT) or magnetic resonance (MR) imaging data for each patient to confirm stroke. Prior imaging studies performed using high-field MR (≥1.5T) have shown that white matter hyperintensities (WMH), signs of microangiopathy in the subcortical brain, are correlated with many stroke risk factors as well as poor stroke outcomes. The aim of this study was the evaluation of MR images (0.3T–1.5T) from the SIREN study to determine associations between WMH volumes in West African patients and both stroke outcomes and stroke risk factors identified in the SIREN study. Materials and methods: Brain MR images of 130 Western African stroke patients (age = 57.87 ± 14.22) were processed through Lesion Segmentation Toolbox of the Statistical Parametric Mapping software to extract all areas of hyperintensity in the brain. WMH was separated from stroke lesion hyperintensity and WMH volume was computed and summed. A stepwise linear regression and multivariate analysis was performed between patients’ WMH volume and sociodemographic and clinical indices. Results: Multivariate analysis showed that high WMH volume was statistically significantly positively correlated with age (β = 0.44, p = 0.001), waist/hip ratio (β = 0.22, p = 0.03), and platelet count (β = 0.19, p = 0.04) after controlling for head size in a Western African stroke population. Conclusion: Associations between WMH and age and waist/hip ratio previously identified in Western countries were demonstrated for the first time in a resource-limited, homogeneous black African community using low-field MR scanners.
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- 2020
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10. Unraveling the Ethical, Legal, and Social Implications of Neurobiobanking and Stroke Genomic Research in Africa: A Study Protocol of the African Neurobiobank for Precision Stroke Medicine ELSI Project
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Rufus O. Akinyemi, Carolyn Jenkins, Michelle Nichols, Arti Singh, Kolawole Wahab, Albert Akpalu, Fred S. Sarfo, Lukman F. Owolabi, Reginald Obiako, Joshua Akinyemi, Babatunde Ojebuyi, Muyiwa Adigun, Rabiu Musbahu, Abiodun Bello, Musibau Titiloye, Benedict Calys-Tagoe, Mayowa Ogunronbi, Ezinne Uvere, Ruth Laryea, Adekunle Fakunle, Osi Adeleye, Olorunyomi Olorunsogbon, Adebayo Ojo, Deborah Adesina, Nathaniel Mensah, Wisdom Oguike, Nathaniel Coleman, Aliyu Mande, Muhammed Uthman, Rajesh N. Kalaria, Ayodele Jegede, Mayowa Owolabi, Bruce Ovbiagele, and Oyedunni Arulogun
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Social sciences (General) ,H1-99 - Abstract
The ethical, legal, and social implications (ELSI) of emerging neurobiobanks and data resources are unclear in an African scientific landscape with unique cultural, linguistic, and belief systems. The overarching goal of the African Neurobiobank for Precision Stroke Medicine–—ELSI Project is to identify, examine, and develop novel approaches to address ELSI issues of biobanking and stroke genomic research in sub-Saharan Africa (SSA). To accomplish the goal we will (1) explore knowledge, attitude, perceptions, barriers, and facilitators influencing ELSI issues related to biobanking and stroke genomic research; (2) use information obtained to craft a community intervention program focused on ELSI issues; and (3) build capacity and careers related to genomics and biobanking for effective client/community engagement while enhancing regulatory, governance, and implementation competences in biobanking science in SSA. A community-based participatory research and mixed-methodological approach, focused on various levels of the social ecological model, will be used to identify and examine relevant ELSI issues. Contextual intervention tools, platforms, and practices will be developed to enhance community understanding and participation in stroke biobanking and genomics research activities while facilitating enduring trust, and equitable and fair utilization of biobanking resources for genetic and trans-omics research. A concurrent capacity building program related to genetic counseling and biobanking will be implemented for early career researchers. The huge potential for neurobiobanking and genomics research in Africa to advance precision medicine applicable to stroke and other neurological disorders requires addressing ELSI challenges while building sustainable research, career, and regulatory capacities in trans-omics and biobanking science.
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- 2020
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11. Epilepsy Care in Nigeria: Factors Influencing Default
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Emmanuel Okechukwu Ezunu, Mayowa Owolabi, Adesola Ogunniyi, and Uduak Williams
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Epilepsy ,Nigeria ,Default ,care ,predictor ,neurological ,Public aspects of medicine ,RA1-1270 - Abstract
Introduction: Epilepsy is a common cause of neurologic disability in developing countries where very few patients with the condition have organized regular follow up. This study was conducted to identify factors influencing default of adult epileptic patients in Ibadan. Methodology: This is a prospective study of subjects with epilepsy seen at the out-patient neurology clinic, University College Hospital, Ibadan Nigeria. A total of 147 patients with epilepsy were recruited consecutively. A structured questionnaire for obtaining information on their demographic characteristics, cost of transportation, estimated distance to the clinic, monthly clinic attendance and seizure frequency was initially applied to each patient who was assigned to be seen monthly for the next six months. Those that defaulted from any subsequent visit were identified and the questionnaire was applied to obtain the reason for default from them. Results: Male gender (p=0.0001), estimated distance (p=0.010), cost of transportation (p=0.013) and age below 40 years (p = 0.01) were identified to have influence on clinic default. But gender is the only significant predictors on clinic default at the multivariate analysis level. Conclusions: Creating more advocacy visits on dangers of clinic default, subsidising transportation and decentralising epilepsy care may improve clinic attendance and seizure control.
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- 2020
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12. H3Africa partnerships to empower clinical research sites to generate high-quality biological samples
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Talishiea Croxton, Ndidi Agala, Emmanuel Jonathan, Olasinbo Balogun, Petronilla J. Ozumba, Enzenwa Onyemata, Shefiya Lawal, Manmak Mamven, Samuel Ajayi, Sylvia E. Melikam, Mayowa Owolabi, Bruce Ovbiagele, Dwomoa Adu, Akinlolu Ojo, Christine Beiswanger, and Alash'le Abimiku
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biobank ,training ,africa ,developing country ,biotechnology ,Public aspects of medicine ,RA1-1270 ,Medicine (General) ,R5-920 - Abstract
Background: The Institute of Human Virology Nigeria (IHVN) – Human Heredity and Health in Africa (H3Africa) Biorepository (I-HAB) seeks to provide high-quality biospecimens for research. This depends on the ability of clinical research sites (CRS) – who provide biospecimens – to operate according to well-established industry standards. Yet, standards are often neglected at CRSs located in Africa. Here, I-HAB reports on its four-pronged approach to empower CRSs to prepare high-quality biospecimens for research. Objectives: I-HAB sought (1) to assess a four-pronged approach to improve biobanking practices and sample quality among CRSs, and (2) to build human capacity. Methods: I-HAB partnered with two H3Africa principal investigators located in Nigeria and Ghana from August 2013 through to May 2017 to debut its four-pronged approach (needs assessment, training and mentorship, pilot, and continuous quality improvement) to empower CRSs to attain high-quality biospecimens. Results: Close collaborations were instrumental in establishing mutually beneficial and lasting relationships. Improvements during the 12 months of engagement with CRSs involved personnel, procedural, and supply upgrades. In total, 51 staff were trained in over 20 topics. During the pilot, CRSs extracted 50 DNA biospecimens from whole blood and performed quality control. The CRSs shipped extracted DNA to I-HAB and I-HAB that comparatively analysed the DNA. Remediation was achieved via recommendations, training, and mentorship. Preanalytical, analytical and post-analytical processes, standard operating procedures, and workflows were systematically developed. Conclusion: Partnerships between I-HAB and H3Africa CRSs enabled research sites to produce high-quality biospecimens through needs assessment, training and mentorship, pilot, and continuous monitoring and improvement.
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- 2020
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13. Capacity-building in clinical skills of rehabilitation workforce in low- and middle-income countries
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Fary Khan, Bhasker Amatya, Wouter de Groote, Mayowa Owolabi, Ilyas M. Syed, Abderrazak Hajjoui, Muhammad N. Babur, Tahir M. Sayed, Yvonne Frizzell, Amaramalar S. Naicker, Maryam Fourtassi, Alaeldin Elmalik, and Mary P. Galea
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disability ,rehabilitation ,skills ,low-andmiddle-incomecountries ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Objective: Despite the prevalence of disability in low-and middle-income countries, the clinical skills of the rehabilitation workforce are not well described. We report health professionals’ perspectives on clinical skills in austere settings and identify context-specific gaps in workforce capacity. Methods: A cross-sectional pilot survey (Pakistan, Morocco, Nigeria, Malaysia) of health professionals’ working in rehabilitation in hospital and community settings. A situational-analysis survey captured assessment of clinical skills required in various rehabilitation settings. Responses were coded in a line-by-line process, and linked to categories in domains of the International Classification of Functioning, Disability and Health (ICF). Results: Respondents (n = 532) from Pakistan 248, Nigeria 159, Morocco 93 and Malaysia 32 included the following: physiotherapists (52.8%), nurses (8.8%), speech (5.3%) and occupational therapists (8.5%), rehabilitation physicians (3.8%), other doctors (5.5%) and prosthetist/orthotists (1.5%). The 10 commonly used clinical skills reported were prescription of: physical activity, medications, transfer-techniques, daily-living activities, patient/carer education, diagnosis/screening, behaviour/cognitive interventions, comprehensive patient-care, referrals, assessments and collaboration. There was significant overlap in skills listed irrespective of profession. Most responses linked with ICF categories in activities/participation and personal factors. Conclusion: The core skills identified reflect general rehabilitation practice and a task-shifting approach, to address shortages of health workers in low-and middle-income countries.
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- 2018
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14. Proposing a new stroke-specific screening tool for depression: Examination of construct validity and reliability
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Akin Ojagbemi, Mayowa Owolabi, Joshua Akinyemi, and Bruce Ovbiagele
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Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Objectives: The optimal tool for identifying depression after stroke is yet to be identified. In the present study, we propose a new context-specific screening tool for PSD and examined its construct validity and reliability within existing data on recent stroke survivors. Methods: We assessed baseline data being collected as part of an intervention to improve one-year blood pressure control among recent (â¤one month) stroke survivors. Depression was measured using the Hospital Anxiety and Depression Scale (HADS-D). We also independently administered the 26-items Health Related Quality of Life in Stroke Patients (HRQOLISP-26), a stroke-specific measure developed from a large cross-cultural sample. Using standard protocol, we identified 6 psychoemotional-domain items of the HRQOLISP-26 fitting a single dimensional model with phenomenological and conceptual overlap with the depression framework in the 10th revision of the International Classification of Diseases (ICD-10). We examined construct validity by comparing HRQOLISP-E with the HADS-D, and known group validity by comparing with age, gender, and stroke severity using both the Pearson product moment coefficient and multivariate regression analyses. Internal consistency and split-half reliability were also determined. Results: Each HRQOLISP-E item (r=â0.40 to â0.53, all p0.8 (0.81â0.93) compared with 0.56â0.68 for the HADS-D (Cronbach's alpha =0.939, versus 0.742 for the HADS-D, Split-half reliability=0.899, versus 0.739 for HADS-D). Conclusion: These results provides preliminary support for further development of the HRQOLISP-E as a context-specific screening tool for PSD through an investigation comparing the proposed measure against a referent-standard clinical diagnostic criteria such as the ICD 10 or Diagnostic and Statistical Manual of Fourth Edition of the Diagnostic and Statistical Manual of Mental Disorders. Keywords: Content validity, Poststroke emotional disturbances, Postsroke mood disorders, Poststroke morbidity, Psychometric properties
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- 2017
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15. Proposed Guideline for Minimum Information Stroke Research and Clinical Data Reporting
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Judit Kumuthini, Lyndon Zass, Melek Chaouch, Michael Thompson, Paul Olowoyo, Mamana Mbiyavanga, Faniyan Moyinoluwalogo, Gordon Wells, Victornia Nembeware, Nicola J. Mulder, Mayowa Owolabi, and H3ABioNet Consortium’s Data and Standard Working Group as members of the H3Africa Consortium
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Stroke ,minimum information requirement guideline ,standardization ,reporting guideline ,data reporting ,H3ABioNet ,Science (General) ,Q1-390 - Abstract
The management and analyses of large datasets is one of the grand challenges of modern biomedical research. Establishing methods to harmonise and standardise data collection, reporting, sharing and the employed data dictionaries, can support the resolution of these challenges whilst improving research quality, data quality and integrity, allowing sustainable knowledge transfer through re-usability, interoperability, reproducibility. The current project aimed to develop and propose a standardised reporting guideline for stroke research and clinical data reporting. Through systematic consolidation and harmonization of published data collection and reporting standards, several recommendations were drafted for the proposed guideline. These recommendations were reviewed by domain-researchers and clinicians using an online survey, developed in REDCap. The survey was completed by 20 international stroke-specialists, majority of respondents were based in Africa (10), followed by America, Europe and Australia (10). Of these respondents; the majority were working as dual clinician-researchers (57%) with more than 10 years’ experience in the field (78%). Data elements within the reporting standard were classified as participant-, study- and experiment-level information, further subdivided into essential or optional information, and defined using existing ontologies. The proposed reporting guideline can be employed for research utility and adapted for clinical utility as well. It is accompanied with an associated XML schema for REDCap implementation, to increase the user friendliness of data capturing, sharing, reporting and governance. Ultimately, the adoption of common reporting in stroke research has the potential to ensure that researchers gain the maximum benefit from their generated data and data collections.
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- 2019
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16. Echocardiographic Abnormalities and Determinants of 1‐Month Outcome of Stroke Among West Africans in the SIREN Study
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Abiodun M. Adeoye, Bruce Ovbiagele, Joshua O. Akinyemi, Okechukwu S. Ogah, Rufus Akinyemi, Mulugeta Gebregziabher, Kolawole Wahab, Adekunle G. Fakunle, Adeseye Akintunde, Oladimeji Adebayo, Akinyemi Aje, Hemant K. Tiwari, Donna Arnett, Francis Agyekum, Lambert T. Appiah, Ganiyu Amusa, Taiwo O. Olunuga, Akpa Onoja, Fred S. Sarfo, Albert Akpalu, Carolyn Jenkins, Daniel Lackland, Lukman Owolabi, Morenikeji Komolafe, Moyinoluwalogo M. Faniyan, Oyedunni Arulogun, Reginald Obiako, and Mayowa Owolabi
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echocardiography ,left ventricular geometry ,morbidity/mortality ,stroke ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Little is known about the relationship between echocardiographic abnormalities and outcome among patients with acute stroke. We investigated the pattern and association of baseline echocardiographic variables with 1‐month disability and mortality among patients with stroke in the SIREN (Stroke Investigative Research and Education Network) study. Methods and Results We enrolled and followed up consecutive 1020 adult patients with acute stroke with baseline transthoracic echocardiography from west Africa. To explore the relationship between echocardiographic variables and 1‐month disability (using modified Rankin scale >3) and fatality, regression models were fitted. Relative risks were computed with 95% CIs. The participants comprised 60% men with a mean age of 59.2±14.6 years. Ischemic stroke was associated with smaller aortic root diameter (30.2 versus 32.5, P=0.018) and septal (16.8 versus 19.1, P
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- 2019
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17. The role of context in implementation research for non-communicable diseases: Answering the 'how-to' dilemma.
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Meena Daivadanam, Maia Ingram, Kristi Sidney Annerstedt, Gary Parker, Kirsty Bobrow, Lisa Dolovich, Gillian Gould, Michaela Riddell, Rajesh Vedanthan, Jacqui Webster, Pilvikki Absetz, Helle Mölsted Alvesson, Odysseas Androutsos, Niels Chavannes, Briana Cortez, Praveen Devarasetty, Edward Fottrell, Francisco Gonzalez-Salazar, Jane Goudge, Omarys Herasme, Hannah Jennings, Deksha Kapoor, Jemima Kamano, Marise J Kasteleyn, Christina Kyriakos, Yannis Manios, Kishor Mogulluru, Mayowa Owolabi, Maria Lazo-Porras, Wnurinham Silva, Amanda Thrift, Ezinne Uvere, Ruth Webster, Rianne van der Kleij, Josefien van Olmen, Constantine Vardavas, Puhong Zhang, and GACD Concepts and Contexts working group
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Medicine ,Science - Abstract
IntroductionUnderstanding context and how this can be systematically assessed and incorporated is crucial to successful implementation. We describe how context has been assessed (including exploration or evaluation) in Global Alliance for Chronic Diseases (GACD) implementation research projects focused on improving health in people with or at risk of chronic disease and how contextual lessons were incorporated into the intervention or the implementation process.MethodsUsing a web-based semi-structured questionnaire, we conducted a cross-sectional survey to collect quantitative and qualitative data across GACD projects (n = 20) focusing on hypertension, diabetes and lung diseases. The use of context-specific data from project planning to evaluation was analyzed using mixed methods and a multi-layered context framework across five levels; 1) individual and family, 2) community, 3) healthcare setting, 4) local or district level, and 5) state or national level.ResultsProject teams used both qualitative and mixed methods to assess multiple levels of context (avg. = 4). Methodological approaches to assess context were identified as formal and informal assessments, engagement of stakeholders, use of locally adapted resources and materials, and use of diverse data sources. Contextual lessons were incorporated directly into the intervention by informing or adapting the intervention, improving intervention participation or improving communication with participants/stakeholders. Provision of services, equipment or information, continuous engagement with stakeholders, feedback for personnel to address gaps, and promoting institutionalization were themes identified to describe how contextual lessons are incorporated into the implementation process.ConclusionsContext is regarded as critical and influenced the design and implementation of the GACD funded chronic disease interventions. There are different approaches to assess and incorporate context as demonstrated by this study and further research is required to systematically evaluate contextual approaches in terms of how they contribute to effectiveness or implementation outcomes.
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- 2019
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18. Validation of the 8-item questionnaire for verifying stroke free status with and without pictograms in three West African languages
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Fred S. Sarfo, Mulugeta Gebregziabher, Bruce Ovbiagele, Rufus Akinyemi, Lukman Owolabi, Reginald Obiako, Kevin Armstrong, Oyedunni Arulogun, Albert Akpalu, Sylvia Melikam, Raelle Saulson, Carolyn Jenkins, and Mayowa Owolabi
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Stroke-free phenotype ,West Africa ,Accuracy ,Pictogram ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background: The Questionnaire for Verifying Stroke-free Status (QVSFS) has been validated in Western populations as a method for verifying stroke-free status in participants of clinical, epidemiological and genetic studies. This instrument has not been validated in low-income settings where populations have limited knowledge of stroke symptoms and literacy levels are low. Objective: To simultaneously validate the 8-item QVSFS in 3 languages spoken in West Africa (Yoruba, Hausa and Akan) for ascertainment of stroke-free status of control subjects in SIREN. Methods: Using a cross-sectional study design, 100 participants each from the 3 linguistic groups will be consecutively recruited from neurology and general medicine clinics of 5 tertiary referral hospitals in Nigeria and Ghana. Ascertainment of stroke status will be determined by neurologists using structured neurological examination, review of case records and neuro-imaging (Gold standard). The relative performance of QVSFS without and with pictures of stroke symptoms (pictograms) will be assessed using sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). Conclusion: The proposed study will provide valuable data on the performance of the QVSFS in resource-limited settings.
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- 2016
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19. Behavioural and Cognitive Effects of Cerebrovascular Diseases
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Mayowa Owolabi, Akin Ojagbemi, Raj Kalaria, Fred Stephen Sarfo, and Rufus Akinyemi
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Published
- 2018
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20. Knowledge, attitudes and practices related to stroke in Ghana and Nigeria: A SIREN call to action.
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Carolyn Jenkins, Bruce Ovbiagele, Oyedunni Arulogun, Arti Singh, Benedict Calys-Tagoe, Rufus Akinyemi, Aliyu Mande, Ezinne Sylvia Melikam, Albert Akpalu, Kolawole Wahab, Fred Stephen Sarfo, Taofeeq Sanni, Godwin Osaigbovo, Hemant K Tiwari, Reginald Obiako, Vincent Shidali, Philip Ibinaiye, Josephine Akpalu, Godwin Ogbole, Lukman Owolabi, Ezinne Uvere, Raelle Taggae, Abiodun Moshood Adeoye, Mulugeta Gebregziabher, Adeseye Akintunde, Oladimeji Adebayo, Ayodipupo Oguntade, Ayotunde Bisi, Kenneth Ohagwu, Ruth Laryea, Peter Olowoniyi, Isah Suleiman Yahaya, Samuel Olowookere, Frederick Adeyemi, Morenikeji Komolafe, Michael Bimbola Fawale, Taofiki Sunmonu, Ugochukwu Onyeonoro, Lucius Chidiebere Imoh, Wisdom Oguike, Taiye Olunuga, Phillip Kolo, Okechukwu S Ogah, Richard Efidi, Ijezie Chukwuonye, Andrew Bock-Oruma, Dorcas Owusu, Chidi Joseph Odo, Moyinoluwalogo Faniyan, Osimhiarherhuo Adeleye Ohnifeman, Olabanji Ajose, Luqman Ogunjimi, Shelia Johnson, Amusa Ganiyu, Paul Olowoyo, Adekunle Gregory Fakunle, Afolaranmi Tolulope, Temitope Farombi, Monica Oghome Obiabo, and Mayowa Owolabi
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Medicine ,Science - Abstract
INTRODUCTION:Stroke is a prominent cause of death, disability, and dementia in sub-Saharan Africa (SSA). The Stroke Investigative Research and Education Network works collaboratively with stroke survivors and individuals serving as community controls to comprehensively characterize the genomic, sociocultural, economic and behavioral risk factors for stroke in SSA. PURPOSE:In this paper, we aim to: i) explore the attitudes, beliefs, and practices related to stroke in Ghana and Nigeria using the process of qualitative description; and ii) propose actions for future research and community-based participation and education. METHODS:Stroke survivors, their caregivers, health care professionals, and community representatives and faith-based leaders participated in one of twenty-six focus groups, which qualitatively explored community beliefs, attitudes and practices related to stroke in Ghana and Nigeria. Arthur Kleinman's Explanatory Model of Illness and the Social Ecological Model guided the questions and/or thematic analysis of the qualitative data. We hereby describe our focus group methods and analyses of qualitative data, as well as the findings and suggestions for improving stroke outcomes. RESULTS AND DISCUSSION:The major findings illustrate the fears, causes, chief problems, treatment, and recommendations related to stroke through the views of the participants, as well as recommendations for working effectively with the SIREN communities. Findings are compared to SIREN quantitative data and other qualitative studies in Africa. As far as we are aware, this is the first paper to qualitatively explore and contrast community beliefs, attitudes, and practices among stroke survivors and their caregivers, community and faith-based leaders, and health professionals in multiple communities within Nigeria and Ghana.
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- 2018
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21. Criterion Validity of the 'HRQOLISP-E': A New Context-Specific Screening Tool for Poststroke Depression
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Akin Ojagbemi, Mayowa Owolabi, Joshua Akinyemi, and Bruce Ovbiagele
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Objectives. The optimal tool for identifying postsroke depression (PSD) is yet to be identified. In the present study, we rely on the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D) as a meaningful criterion to investigate the psychometric properties of the HRQOLISP-E, a new context-specific screening tool for PSD developed from a large cross-cultural sample. Methods. We assessed baseline data being collected as part of an intervention to improve one-year blood pressure control among recent (≤one month) stroke survivors. Depression was measured using the HADS-D and the HRQOLISP-E. We determined sensitivity, specificity, likelihood ratios, and posttest probability. The area under a receiver operator curve (AUC) and the most appropriate HRQOLISP-E cut-off were also determined using standard procedures. Results. Using data derived from 387 recent stroke survivors, the HRQOLISP-E showed high agreement with the HADS-D, sensitivity = 73.7%, specificity = 79.3%, and posterior test probability = 88% (95% CI = 84%–91%). The AUC was 0.81 (95% CI = 0.76–0.86). The HRQOLISP-E cut-off, corresponding to HADS-D score ≥ 8, was 20/21 (out of a total score of 30). Conclusions. Within limitations of using the HADS-D as a referent criterion, the present results provide justification for further development of the HRQOLISP-E as the first stroke-specific screening tool for depression.
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- 2017
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22. Depression after Stroke in Sub-Saharan Africa: A Systematic Review and Meta-Analysis
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Akin Ojagbemi, Onoja Akpa, Fisayo Elugbadebo, Mayowa Owolabi, and Bruce Ovbiagele
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Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Objective. We aimed to conduct a systematic review and meta-analysis of prevalence and characteristics of poststroke depression (PSD) in sub-Saharan Africa (SSA). Methods. We searched Medline, PsycINFO, and African Journals OnLine using keywords for stroke and depression and the .mp. operator for all 54 SSA countries/regions. Further information was retrieved through a manual search of references from relevant published and unpublished articles. We included only peer-reviewed original studies with epidemiological or experimental designs, conducted random-effect meta-analysis, and identified the most commonly associated factors by weight (inverse of variance method). Results. Seventeen studies, comprising 1483 stroke survivors, met the criteria for syntheses. The pooled frequency of clinically diagnosed PSD was 31% (95% CI = 26%–36%), versus 13.9% in healthy control pairs. Prevalence did not vary much across healthcare settings but was affected by methods of depression ascertainment. PSD was significantly associated with low education, cognitive impairment, physical disability, poor quality of life, and divorced marital status. Conclusion. Almost 1 in 3 individuals with stroke in SSA has clinical depression. Despite limitations around quality of identified studies, results of the present systematic review overlap with findings in the global literature and highlight useful targets for the design and trial of tailored intervention for PSD in SSA.
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- 2017
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23. Call for Papers: Neuro-rehabilitation in low and middle income countries: Adaptations and Innovations
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Mayowa Owolabi, Adesola Ogunniyi, Talhatu K. Hamzat, Thomas Platz, and Fary Khan
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Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2017
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24. Factors Associated with Insomnia among Elderly Patients Attending a Geriatric Centre in Nigeria
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Adetola M. Ogunbode, Lawrence A. Adebusoye, Olufemi O. Olowookere, Mayowa Owolabi, and Adesola Ogunniyi
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Geriatrics ,RC952-954.6 - Abstract
Background. Insomnia is a form of chronic sleep problem of public health importance which impacts the life of elderly people negatively. Methods. Cross-sectional study of 843 elderly patients aged 60 years and above who presented consecutively at Geriatric Centre, University College Hospital, Ibadan, Nigeria. The World Health Organization Composite International Diagnostic Interview was used to diagnose insomnia. We assessed the following candidate variables which may be associated with insomnia such as socidemographic characteristics, morbidities, and lifestyle habits. Statistical analysis was done with SPSS 17. Results. The point prevalence of insomnia was 27.5%. Insomnia was significantly associated with being female, not being currently married, having formal education, living below the poverty line, and not being physically active. Health complaints of abdominal pain, generalized body pain, and persistent headaches were significantly associated with insomnia. Conclusion. The high prevalence of insomnia among elderly patients in this setting calls for concerted effort by healthcare workers to educate the elderly on lifestyle modification.
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- 2014
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25. Beyond Exploratory Data: Using Cluster Detection Tests to Pinpoint Malaria Hotspots in Nigeria
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Oyamakin, S. O., primary and Mayowa, Owolabi, additional
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- 2024
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26. Mechanical Thrombectomy Global Access For Stroke (MT-GLASS): A Mission Thrombectomy (MT-2020 Plus) Study
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Kaiz S. Asif, Fadar O. Otite, Shashvat M. Desai, Nabeel Herial, Violiza Inoa, Fawaz Al-Mufti, Ashutosh P. Jadhav, Adam A. Dmytriw, Alicia Castonguay, Priyank Khandelwal, Jennifer Potter-Vig, Viktor Szeder, Tanzila Kulman, Victor Urrutia, Hesham Masoud, Gabor Toth, Kaustubh Limaye, Sushanth Aroor, Waleed Brinjikji, Ansaar Rai, Jeyaraj Pandian, Mehari Gebreyohanns, Thomas Leung, Ossama Mansour, Andrew M. Demchuk, Vikram Huded, Sheila Martins, Osama Zaidat, Xiaochuan Huo, Bruce Campbell, P.N. Sylaja, Zhongrong Miao, Jeffrey Saver, Santiago Ortega-Gutierrez, Dileep R. Yavagal, Juan Jose Cirio, Pedro Lylyk, Angel Ferrario, Luis Lemme Plaghos, José Arroyo, Bernard Yan, Ronil Chandra, Wael Hamed Ibrahim, Firas Alnidawi, Sirajee Shafiqul Islam, Mohammad Shahidullah, Víctor Villarroel Saavedra, Francisco Josà Mont’ Alverne, Pedro Magalhaes, Gisele Sampaio Silva, Stanimir Sirakov, Rosen Kalpachki, Nurfet Alioski, Eric Gueumekane bila lamou, Jai Shankar, Grant Stotts, Daidre Rowe, Francene Gayle, Romnesh de Souza, Cristina Ramos, Amaury GarcÃa, Amza Ali, Sherry Sandy, Pablo M. Lavados, Rodrigo Rivera, TONY FABIÁN ÁLVAREZ GUZMÁN, Alejandro Villarraga, Carolina Estrada, Boris Pabon, Antonin Krajina, Aleš Tomek, Philip B Adebayo, GERMAN ABDO, Nelson Maldonado S, Farouk Hassan, Eman M Khedr, Mirza Khinikadze, ZURAB NADAREISHVILI, Alexander Tsiskaridze, Nikolaos Syrmos, Panayiotis Mitsias, Biplab Das, Jayanta Roy, Vivek Gupta, Vipul Gupta, Dheeraj Khurana, Anil Karapurkar, M.V.Padma Stivastava, Anand Alurkar, Arvind Sharma, Satish Lahoti, Rahul Kumar, Gigy Varkey Kuruttukulam, Achmad Firdaus Sani, Ita Muharram Sari, Mustafa Khassaf, Temeem Majid Nassir, Nobuyuki Sakai, Hiroshi Yamagami, Haitham Dababneh, Farid A. Aladham, Mynzhylky Berdikhojayev, Sabina Medukhanova, Raghid Kikano, Ali Alaraj, Rechdi Ahdab, Wan Asyraf Wan Zaidi, Khairul Azmi Abd Kadir, Antonio Arauz, Fernando Gongora, Ariunaa Jambaldorj, Ganbaatar XXX, Zarni Myint Shwe, Win Min Thit, Anna Ranta, Teddy Wu, ERWIN E. RAYO, Mayowa Owolabi, Akintomiwa Makanjuola, Saima Ahmad, MOHAMMAD WASAY, Umair Rashid, Ricardo Mernes, Osvaldo Paniagua, MARLA GALLO, Manuel Moquillaza, Maria Epifania Collantes, Manuel M. Mariano, Adam Kobayashi, Rafael Rodriguez-Mercado, Rodolfo Alcedo Guardia, Yahia Imam, Ayman Zakaria Ahmed, Adel Alhazzani, Hosam M. Al-Jehani, Wickly Lee, Kamil ZELEŇÁK, Andrej Klepanec, GEORGI KRASTEV, Senta Frol, Naeem Brey, Anastasia Rossouw, Prasad De Silva, Harsha Gunasekera, Udaya Ranawaka, Haytham Osman, Sarah M El-Sadig, Nijasri C. Suwanwela, Wasan Akarathanawat, Jarturon Tantivatana, Nadia Hammami, Samia Ben Sassi, Atilla Ozcan Ozdemir, Semih Giray, Dmytro Lebedynets, Stanislav Konotopchik, Seby John, Syed Irteza Hussain, Robin Novakovic-White, Gillian L. Gordon Perue, Ryna Then, Claudio Berrutti, Roberto Crosa, Huy Thang Nguyen, Huynh Vu Le, and Tran thanh vu
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Background: Despite the well-established potent benefit of mechanical thrombectomy (MT) for large vessel occlusion (LVO) stroke, access to MT has not been studied globally. We conducted a worldwide survey of countries on 6 continents to define MT access (MTA), the disparities in MTA, and its determinants on a global scale. Methods: Our survey was conducted in 75 countries through the Mission Thrombectomy 2020+ global network between November 22, 2020, and February 28, 2021. The primary end points were the current annual MTA, MT operator availability, and MT center availability. MTA was defined as the estimated proportion of patients with LVO receiving MT in a given region annually. The availability metrics were defined as ([current MT operators×50/current annual number of estimated thrombectomy-eligible LVOs]×100 = MT operator availability) and ([current MT centers×150/current annual number of estimated thrombectomy-eligible LVOs]×100= MT center availability). The metrics used optimal MT volume per operator as 50 and an optimal MT volume per center as 150. Multivariable-adjusted generalized linear models were used to evaluate factors associated with MTA. Results: We received 887 responses from 67 countries. The median global MTA was 2.79% (interquartile range, 0.70–11.74). MTA was Conclusions: Access to MT on a global level is extremely low, with enormous disparities between countries by income level. The significant determinants of MT access are the country’s per capita gross national income, prehospital LVO triage policy, and MT operator and center availability.
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- 2023
27. Stroke Learning Health Systems: A Topical Narrative Review With Case Examples
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Dominique A. Cadilhac, Dawn M. Bravata, Janet Prvu Bettger, Robert Mikulik, Bo Norrving, Ezinne O. Uvere, Mayowa Owolabi, Annemarei Ranta, and Monique F. Kilkenny
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Advanced and Specialized Nursing ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine - Abstract
To our knowledge, the adoption of Learning Health System (LHS) concepts or approaches for improving stroke care, patient outcomes, and value have not previously been summarized. This topical review provides a summary of the published evidence about LHSs applied to stroke, and case examples applied to different aspects of stroke care from high and low-to-middle income countries. Our attempt to systematically identify the relevant literature and obtain real-world examples demonstrated the dissemination gaps, the lack of learning and action for many of the related LHS concepts across the continuum of care but also elucidated the opportunity for continued dialogue on how to study and scale LHS advances. In the field of stroke, we found only a few published examples of LHSs and health systems globally implementing some selected LHS concepts, but the term is not common. A major barrier to identifying relevant LHS examples in stroke may be the lack of an agreed taxonomy or terminology for classification. We acknowledge that health service delivery settings that leverage many of the LHS concepts do so operationally and the lessons learned are not shared in peer-reviewed literature. It is likely that this topical review will further stimulate the stroke community to disseminate related activities and use keywords such as learning health system so that the evidence base can be more readily identified.
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- 2023
28. Global stroke statistics 2022
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Tharshanah Thayabaranathan, Joosup Kim, Dominique A Cadilhac, Amanda G Thrift, Geoffrey A Donnan, George Howard, Virginia J Howard, Peter M Rothwell, Valery Feigin, Bo Norrving, Mayowa Owolabi, Jeyaraj Pandian, Liping Liu, and Muideen T Olaiya
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Stroke ,Neurology ,International Classification of Diseases ,Incidence ,Humans ,Registries ,World Health Organization ,Global Health ,Article - Abstract
Background: Contemporary data on stroke epidemiology and the availability of national stroke clinical registries are important for providing evidence to improve practice and support policy decisions. Aims: To update the most current incidence, case-fatality, and mortality rates on stroke and identify national stroke clinical registries worldwide. Methods: We searched multiple databases (based on our existing search strategy) to identify new original papers, published between 1 November 2018 and 15 December 2021, that met ideal criteria for data on stroke incidence and case-fatality, and added these to the studies reported in our last review. To identify national stroke clinical registries, we updated our last search, using PubMed, from 6 February 2015 until 6 January 2022. We also screened reference lists of review papers, citation history of papers, and the gray literature. Mortality codes for International Classification of Diseases (ICD)-9 and ICD-10 were extracted from the World Health Organization (WHO) for each country providing these data. Population denominators were obtained from the United Nations (UN) or WHO (when data were unavailable in the UN database). Crude and adjusted stroke mortality rates were calculated using country-specific population denominators, and the most recent years of mortality data available for each country. Results: Since our last report in 2020, there were two countries (Chile and France) with new incidence studies meeting criteria for ideal population-based studies. New data on case-fatality were found for Chile and Kenya. The most current mortality data were available for the year 2014 (1 country), 2015 (2 countries), 2016 (11 countries), 2017 (10 countries), 2018 (19 countries), 2019 (36 countries), and 2020 (29 countries). Four countries (Libya, Solomon Islands, United Arab Emirates, and Lebanon) reported mortality data for the first time. Since our last report on registries in 2017, we identified seven more national stroke clinical registries, predominantly in high-income countries. These newly identified registries yielded limited information. Conclusions: Up-to-date data on stroke incidence, case-fatality, and mortality continue to provide evidence of disparities and the scale of burden in low- and middle-income countries. Although more national stroke clinical registries were identified, information from these newly identified registries was limited. Highlighting data scarcity or even where a country is ranked might help facilitate more research or greater policy attention in this field.
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- 2022
29. Frequent vegetable consumption is inversely associated with hypertension among indigenous Africans
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Onoja Matthew Akpa, Akinkunmi Paul Okekunle, Osahon Jeffery Asowata, Tinashe Chikowore, Shukri F Mohamed, Fred Sarfo, Rufus Akinyemi, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe, Lukman Owolabi, Godwin O Osaigbovo, Godwin Ogbole, Hemant K Tiwari, Joshua Akinyemi, Adekunle Fakunle, Ezinne Uvere, Abiodun M Adeoye, Daniel Lackland, Donna K Arnett, Bruce Ovbiagele, Michèle Ramsay, and Mayowa Owolabi
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Epidemiology ,Cardiology and Cardiovascular Medicine - Abstract
Aims The relationship between vegetable consumption and hypertension occurrence remains poorly characterized in sub-Saharan Africa. This study assessed the association of vegetable consumption with odds of hypertension among indigenous Africans. Methods and results We harmonized data on prior vegetable consumption and hypertension occurrence (defined as one of the following conditions; systolic blood pressure ≥140 or diastolic blood pressure ≥90 mmHg or previous diagnosis or use of antihypertensive medications) from 16 445 participants across five African countries (Nigeria, South Africa, Kenya, Ghana and Burkina Faso) in the Stroke Investigative Research and Educational Network and Africa Wits-INDEPTH partnership for Genomic studies. Vegetable consumption (in servings/week) was classified as ‘low’ ( Conclusion Indigenous Africans who consumed at least 12 servings of vegetables per week were less likely to be found hypertensive, particularly among males and young adults.
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- 2022
30. Correction to: African Control of Hypertension through Innovative Epidemiology and a Vibrant Ecosystem (ACHIEVE): novel strategies for accelerating hypertension control in Africa
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Mayowa Owolabi, Paul Olowoyo, Ana Mocumbi, Okechukwu S. Ogah, Augustine Odili, Kolawole Wahab, Dike Ojji, Abiodun M. Adeoye, Rufus Akinyemi, Albert Akpalu, Reginald Obiako, Fred S. Sarfo, Charlotte Bavuma, Hind Mamoun Beheiry, Moshen Ibrahim, Wafaa El Aroussy, Gianfranco Parati, Anastase Dzudie, Sandhya Singh, Onoja Akpa, Andre Pascal Kengne, Akinkunmi Paul Okekunle, Ama de Graft Aikins, Charles Agyemang, Gbenga Ogedegbe, Bruce Ovbiagele, Renu Garg, Norman R. C. Campbell, Daniel T. Lackland, Prebo Barango, Slim Slama, Cherian V. Varghese, Paul K. Whelton, and Xin-Hua Zhang
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- 2023
31. African Control of Hypertension through Innovative Epidemiology and a Vibrant Ecosystem (ACHIEVE): novel strategies for accelerating hypertension control in Africa
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Mayowa Owolabi, Paul Olowoyo, Ana Mocumbi, Okechukwu S. Ogah, Augustine Odili, Kolawole Wahab, Dike Ojji, Abiodun M. Adeoye, Rufus Akinyemi, Albert Akpalu, Reginald Obiako, Fred S. Sarfo, Charlotte Bavuma, Hind Mamoun Beheiry, Moshen Ibrahim, Wafaa El Aroussy, Gianfranco Parati, Anastase Dzudie, Sandhya Singh, Onoja Akpa, Andre Pascal Kengne, Akinkunmi Paul Okekunle, Ama de Graft Aikins, Charles Agyemang, Gbenga Ogedegbe, Bruce Ovbiagele, Renu Garg, Norman R. C. Campbell, Daniel T. Lackland, Prebo Barango, Slim Slama, Cherian V. Varghese, Paul K. Whelton, and Xin-Hua Zhang
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- 2023
32. Peer Review Report For: Stroke pathway — An evidence base for commissioning — An evidence review for NHS England and NHS Improvement [version 1; peer review: 2 approved with reservations]
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Mayowa Owolabi
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- 2023
33. Use of multidimensional item response theory methods for dementia prevalence prediction: an example using the Health and Retirement Survey and the Aging, Demographics, and Memory Study.
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Emma Nichols, Foad Abd-Allah, Amir Abdoli, Ahmed Abualhasan, Eman Abu-Gharbieh, Ashkan Afshin, Rufus Akinyemi, Fahad Mashhour Alanezi, Vahid Alipour, Amir Almasi-Hashiani, Jalal Arabloo, Amir Ashraf-Ganjouei, Getinet Ayano, José Luis Ayuso-Mateos, Atif Amin Baig, Maciej Banach, Miguel A. Barboza, Suzanne Lyn Barker-Collo, Bernhard T. Baune, Akshaya Srikanth Bhagavathula, Krittika Bhattacharyya, Ali Bijani, Atanu Biswas, Archith Boloor, Carol Brayne, Hermann Brenner, Katrin Burkart, Sharath Burugina Nagaraja, Felix Carvalho, Luis F. S. Castro-de-Araujo, Ferrán Catalá-López, Ester Cerin, Nicolas Cherbuin, Dinh-Toi Chu, Xiaochen Dai, Antonio Reis de Sá-Junior, Shirin Djalalinia, Abdel Douiri, David Edvardsson, Shaimaa I. El-Jaafary, Sharareh Eskandarieh, Andre Faro, Farshad Farzadfar, Valery Feigin, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Pietro Ferrara 0002, Irina Filip, Florian Fischer, Shilpa Gaidhane, Lucia Galluzzo, Gebreamlak Gebremedhn Gebremeskel, Ahmad Ghashghaee, Alessandro Gialluisi, Elena V. Gnedovskaya, Mahaveer Golechha, Rajeev Gupta, Vladimir Hachinski, Mohammad R. Haider, Teklehaimanot Gereziher Haile, Mohammad Hamiduzzaman, Graeme J. Hankey, Simon I. Hay, Golnaz Heidari, Reza Heidari-Soureshjani, Hung Chak Ho, Mowafa S. Househ, Bing-Fang Hwang, Licia Iacoviello, Olayinka Stephen Ilesanmi, Irena M. Ilic, Milena D. Ilic, Seyed Sina Naghibi Irvani, Masao Iwagami, Ihoghosa Osamuyi Iyamu, Ravi Prakash Jha, Rizwan Kalani, André Karch, Ayele Semachew Kasa, Yousef S. Khader, Ejaz Ahmad Khan, Mahalaqua Nazli Khatib, Yun Jin Kim, Sezer Kisa, Adnan Kisa, Mika Kivimäki, Ai Koyanagi, Manasi Kumar, Iván Landires, Savita Lasrado, Bingyu Li, Stephen S. Lim, Xuefeng Liu, Shilpashree Madhava Kunjathur, Azeem Majeed, Preeti Malik, Man Mohan Mehndiratta, Ritesh G. Menezes, Yousef Mohammad, Salahuddin Mohammed, Ali H. Mokdad, Mohammad Ali Moni, Gabriele Nagel, Muhammad Naveed 0005, Vinod C. Nayak, Cuong Tat Nguyen, Thi Lan Huong Nguyen, Virginia Nunez-Samudio, Andrew T. Olagunju, Samuel M. Ostroff, Nikita Otstavnov, Mayowa Owolabi, Fatemeh Pashazadeh Kan, Urvish K. Patel, Michael R. Phillips, Michael A. Piradov, Constance Dimity Pond, Faheem Hyder Pottoo, Sergio I. Prada, Amir Radfar, Fakher Rahim, Juwel Rana, Vahid Rashedi, Salman Rawaf, David Laith Rawaf, Nickolas Reinig, Andre M. N. Renzaho, Nima Rezaei, Aziz Rezapour, Michele Romoli, Gholamreza Roshandel, Perminder S. Sachdev, Amirhossein Sahebkar, Mohammad Ali Sahraian, Mehrnoosh Samaei, Mete Saylan, Feng Sha, Masood Ali Shaikh, Kenji Shibuya, Mika Shigematsu, Jae Il Shin, Rahman Shiri, Diego Augusto Santos Silva, Jasvinder A. Singh, Deepika Singhal, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Amin Soheili, Houman Sotoudeh, Emma Elizabeth Spurlock, Cassandra E. I. Szoeke, Rafael Tabarés-Seisdedos, Biruk Wogayehu Taddele, Marcos Roberto Tovani-Palone, Gebiyaw Wudie Tsegaye, Marco Vacante, Narayanaswamy Venketasubramanian, Simone Vidale, Vasily Vlassov, Giang Thu Vu, Yuan-Pang Wang, Jordan Weiss, Abrha Hailay Weldemariam, Ronny Westerman, Anders Wimo, Andrea Sylvia Winkler, Chenkai Wu, Ali Yadollahpour, Metin Yesiltepe, Naohiro Yonemoto, Chuanhua Yu, Mikhail Sergeevich Zastrozhin, Anasthasia Zastrozhina, Zhi-Jiang Zhang, Christopher J. L. Murray, and Theo Vos
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- 2021
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34. Human Rights Implications of Stroke Biobanking and Genomics Research in Sub-Saharan Africa
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Muyiwa Adigun, Babatunde Raphael Ojebuyi, Joshua Akinyemi, Kolawole Wahab, Albert Akpalu, Fred S. Sarfo, Lukman F. Owolabi, Rabiu Musbahu, Abiodun Bello, Reginald Obiako, Mayowa Ogunronbi, Arti Singh, Michelle Nichols, Carolyn Jenkins, Ayodele Jegede, Rajesh Kalaria, Mayowa Owolabi, Bruce Ovbiagele, Oyedunni Arulogun, and Rufus Akinyemi
- Subjects
Sociology and Political Science ,Law - Abstract
Stroke is a major cause of death in Sub-Saharan Africa (ssa) and genetic factors appear to play a part in its pathogenesis. This led to the development of stroke biobanking and genomics research in ssa. Existing stroke studies have focused on causes, incidence rates, fatalities and effects. However, scant attention has been paid to the legal issues about stroke biobanking and genomics research in the sub-region. Therefore, this article examines the legal implications of stroke biobanking and genomics research in Sub-Saharan Africa from a human rights perspective. The study argues that the right to dignity of the human person, the right to privacy, the right to freedom of information, the right to freedom from discrimination, the right to own property, the right to self-determination and the right to health may be implicated. The study concludes that the court may have to be involved in balancing one right against the other which may prove somewhat herculean depending on the circumstances of each case.
- Published
- 2022
35. Crafting Community-Based Participatory Research Stroke Interventions
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Michelle Nichols, Gayenell Magwood, Michelle Woodbury, Kimberly Brown, Carolyn Jenkins, and Mayowa Owolabi
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Advanced and Specialized Nursing ,Stroke ,Community-Based Participatory Research ,SARS-CoV-2 ,COVID-19 ,Humans ,Neurology (clinical) ,Health Status Disparities ,Public Health ,Cardiology and Cardiovascular Medicine ,Pandemics ,Article - Abstract
Stroke exerts a tremendous burden on individuals, families, communities, and health systems globally. Even more troublesome are the striking disparities faced across diverse populations. These disparities are further exacerbated by the Coronavirus Disease 2019 pandemic. Despite efforts to advance stroke research, substantial gaps remain in understanding factors that contribute to stroke disparities, including the Social Determinants of Health. Strategically designed studies and tailored interventions are needed to bridge the inequities high-risk populations face and to meet their specific needs. Community-based participatory research offers an approach to equitably partner with community members to understand and work collaboratively to address community-specific health priorities. In this focused update, we highlight the main processes of community-based participatory research studies and share exemplars from our team’s work in stroke research and from the literature. As we continue to face an increasing prevalence of stroke, compounded by the Coronavirus Disease 2019 pandemic and ongoing implications of the Social Determinants of Health, partnering with communities to address community-driven health priorities can inform interventions targeted to overcome the disparities faced by certain populations.
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- 2023
36. Stroke in Africa: a systematic review and meta-analysis of the incidence and case-fatality rates
- Author
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Akinkunmi Paul Okekunle, Stephanie Jones, Olaleye Adeniji, Caroline Watkins, Maree Hackett, Gian Luca Di Tanna, Mayowa Owolabi, and Rufus Akinyemi
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Neurology - Abstract
Background: The burden of stroke (a leading cause of disability and mortality) in Africa appears to be increasing, but a systematic review of the best available data to support or refute this observation is lacking. Aim: To determine the incidence and 1-month case-fatality rates from high-quality studies of stroke epidemiology among Africans. Summary of review: We searched and retrieved eligible articles on stroke epidemiology among indigenous Africans in bibliographic databases (MEDLINE, ScienceDirect, Google Scholar, and Cochrane library) using predefined search terms from the earliest records through January 2022. Methodological assessment of eligible studies was conducted using the Newcastle–Ottawa scale. Pooling of incidence and case-fatality rates was performed via generalized linear models (Poisson-Normal random-effects model). Of the 922 articles retrieved, 14 studies were eligible for inclusion. The total number of stroke cases was 2568, with a population denominator (total sample size included in population-based registries or those who agreed to participate in door-to-door community studies) of 3,384,102. The pooled crude incidence rate of stroke per 100,000 persons in Africa was 106.49 (95% confidence interval (CI) = 58.59–193.55), I2 = 99.6%. The point estimate of the crude incidence rate was higher among males, 111.33 (95% CI = 56.31–220.12), I2 = 99.2%, than females, 91.14 (95% CI = 47.09–176.37), I2 = 98.9%. One-month case-fatality rate was 24.45 (95% CI = 16.84–35.50), I2 = 96.8%, with lower estimates among males, 22.68 (95% CI = 18.62–27.63), I2 = 12.9%, than females, 27.57 (95% CI = 21.47–35.40), I2 = 51.6%. Conclusion: The burden of stroke in Africa remains very high. However, little is known about the dynamics of stroke epidemiology among Africans due to the dearth of high-quality evidence. Further continent-wide rigorous epidemiological studies and surveillance programs using the World Health Organization STEPwise approach to Surveillance (WHO STEPS) framework are needed.
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- 2022
37. PS-P09-9: DIETARY PATTERNS AND HYPERTENSION AMONG STROKE-FREE AFRICANS IN THE SIREN STUDY
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Akinkunmi Paul Okekunle, Osahon Jeffery Asowata, Onoja Matthew Akpa, Adekunle Fakunle, Fred Stephen Sarfo, Kolawole Wahab, Reginald Obiako, Rufus Akinyemi, Bruce Ovbiagele, and Mayowa Owolabi
- Subjects
Physiology ,Internal Medicine ,Cardiology and Cardiovascular Medicine - Published
- 2023
38. Symbolic legislation and the regulation of stroke biobanking and genomics research in Sub-Saharan Africa
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Muyiwa Adigun, Babatunde Raphael Ojebuyi, Joshua Akinyemi, Kolawole Wahab, Albert Akpalu, Fred S. Sarfo, Lukman F. Owolabi, Rabiu Musbahu, Abiodun Bello, Reginald Obiako, Mayowa Ogunronbi, Arti Singh, Michelle Nichols, Carolyn Jenkins, Ayodele Jegede, Rajesh Kalaria, Mayowa Owolabi, Bruce Ovbiagele, Oyedunni Arulogun, and Rufus Akinyemi
- Subjects
Law ,Article - Abstract
Stroke is a major cause of death in Sub-Saharan Africa (SSA) and genetic factors appear to play a part. This led to the development of stroke bio-banking and genomics research in SSA. Existing stroke studies have focused on causes, incidence rates, fatalities and effects. However, scant attention has been paid to the legal issues about stroke bio-banking and genomics research in the sub-region. Therefore, this article examines how genomics research and stroke bio-banking in SSA can be regulated through legislation. The article reports that there are germane issues to be addressed such as appropriate consent model, commercial use of biological samples, ownership right in biological samples and return of research results but that the position of the law on these issues is not satisfactory because there are no statute directly regulating them while existing regulations in these countries are either absent, outdated, conservative or difficult to navigate. The article therefore applies the theory of symbolic legislation and argues for legislative intervention through positive symbolic approach. It recommends that the statute to be enacted should only address policy issues by way of legal rules without being detailed while the understanding of the rules should be fostered in explanatory notes. The explanatory notes should contain examples borne of decided cases, cases settled out of court and the ethical guidelines prepared by Human Heredity and Health in Africa (H3 Africa). Where they are inadequate, recourse may be had to other ethical guidelines subject to the demands of local circumstances.
- Published
- 2021
39. Abstract P069: Vegetable Consumption And Hypertension Among 16,445 Africans
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Akinkunmi Okekunle, Onoja Akpa, Osahon Asowata, Tinashe Chikowore, Shukri Mohamed, FRED S SARFO, Rufus O Akinyemi, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe, Lukman Owolabi, Godwin Osaigbovo, Godwin Ogbole, Hemant K Tiwari, Joshua Akinyemi, Adekunle Fakunle, Ezinne Uvere, Abiodun Adeoye, Daniel T Lackland, Donna K Arnett, Bruce Ovbiagele, Michèle Ramsay, and Mayowa Owolabi
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Internal Medicine - Abstract
Background: The association of vegetable consumption with hypertension remains poorly described in sub-Saharan Africa. This study assessed the relationship between vegetable consumption and hypertension among indigenous Africans. Methods: We harmonized data on the frequency of vegetable consumption (servings/week) and hypertension (defined as systolic blood pressure ≥ 140mmHg or diastolic blood pressure ≥ 90mmHg or previous diagnosis or use of antihypertensive medications) from 16,445 participants across five African countries (Ghana, Burkina Faso, Kenya, Nigeria and South Africa) from the SIREN and AWI-Gen studies. Using the recommendation of at least five servings/day (35 servings/week) adapted from the World Health Organization recommendations, and vegetable consumption was classified as 'inadequate' (P Results: The mean age of participants was 53.0±10.7years, 45.9% (7,552 of 16,445) were males, and 42.9% (7,070 of 16,445) were hypertensives. Adequate vegetable consumption was associated with lower odds of hypertension; OR: 0.86 (95%CI: 0.76, 0.97). The sex-stratified odds was; OR: 0.87 (95%CI: 0.73, 1.02) for females and 0.84 (95%CI: 0.71, 1.00) for males. Conclusion: These findings provide new evidence for promoting regular vegetable consumption in the guidelines for the primary prevention of hypertension among Africans.
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- 2022
40. Abstract P017: Association Of Secondhand Smoke Exposure With Hypertension Among Non-smoking Stroke-free Africans
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Akinkunmi Okekunle, Osahon Asowata, Onoja Akpa, Adekunle Fakunle, FRED S SARFO, Albert Akpalu, Reginald Obiako, Kolawole Wahab, Godwin Osaigbovo, Lukman Owolabi, Morenikeji Komolafe, Rufus O Akinyemi, Bruce Ovbiagele, and Mayowa Owolabi
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Internal Medicine - Abstract
Background: Secondhand smoking (SHS) is the exposure to smoke arising from a burning cigarette or exhaled by a smoker. It is a significant public health problem worldwide and whether it is associated with hypertension, particularly among Africans, is yet to be clearly understood. This study evaluated the relationship between SHS and hypertension among stroke-free adults who are non-smokers in the Stroke Investigation Research and Educational Network (SIREN) study. Methods: We identified 3905 adults (≥18years who had never smoked) in the SIREN study conducted in Ghana and Nigeria. Participants reported a history of SHS exposure in an indoor environment. Hypertension was defined as one of the following conditions; mean SBP≥140mmHg, DBP≥90mmHg or use of antihypertensive medications. Logistic regression was used to estimate the multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI) for hypertension by SHS exposure at a two-sided P Results: Overall, mean age was 55.8±14.9years, 18.2% (712 of 3905) had SHS exposure, with a higher proportion among males 20.0% (360 of 1803) than females 16.7% (352 of 2102). SHS was associated with higher odds of having hypertension in the overall population; OR: 1.2 (95%CI: 1.0, 1.5) among females; OR: 1.6 (95%CI: 1.2, 2.1), but not among males; OR: 0.9 (95%CI: 0.7, 1.2). Conclusion: SHS was associated with higher odds of hypertension, particularly among females in this sample. The viability of public interventions in mitigating the potential effect of SHS cannot be underestimated in managing the hypertension burden among Africans, pending longitudinal studies to establish causal associations between SHS and hypertension.
- Published
- 2022
41. Legal Implications of Stroke Biobanking and Genomics Research in Sub-Saharan Africa
- Author
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Muyiwa, Adigun, Babatunde Raphael, Ojebuyi, Joshua, Akinyemi, Kolawole, Wahab, Albert, Akpalu, Fred S, Sarfo, Lukman F, Owolabi, Rabiu, Musbahu, Abiodun, Bello, Reginald, Obiako, Mayowa, Ogunronbi, Arti, Singh, Michelle, Nichols, Carolyn, Jenkins, Ayodele, Jegede, Rajesh, Kalaria, Mayowa, Owolabi, Bruce, Ovbiagele, Oyedunni, Arulogun, and Rufus, Akinyemi
- Subjects
Stroke ,Humans ,Genomics ,Africa South of the Sahara ,Biological Specimen Banks - Abstract
Stroke is a major cause of death in Sub-Saharan Africa (SSA) and genetic factors appear to play a part. This has led to stroke biobanking and genomics research in SSA. Existing stroke studies have focused on causes, incidence rates, fatalities and effects. However, scant attention has been paid to the legal issues in stroke biobanking and genomics research in the sub-region. Therefore, this article examines the legal implications of stroke biobanking and genomics research in SSA. The article adopts a textual analysis of primary and secondary sources in law. It reports that there are laws from the perspectives of human right, the common law, and intellectual property. However, there are gaps to be filled. The article therefore argues for legislative intervention. It concludes that pending the time the statute will be enacted, genomics researchers in Africa should adopt the ethical guidelines prepared by Human Heredity and Health in Africa (H3 Africa).
- Published
- 2022
42. DETERMINANTS OF STROKE MORTALITY AMONG WEST AFRICANS: FINDINGS FROM THE SIREN STUDY
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Akinkunmi Paul Okekunle, Fred Stephen Sarfo, Onoja Matthew Akpa, Osahon Jeffery Asowata, Joshua Akinyemi, Adekunle Fakunle, Godwin Ogbole, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe, Godwin Osaigbovo, Lukman Owolabi, Rufus Akinyemi, Bruce Ovbiagele, and Mayowa Owolabi
- Subjects
Rehabilitation ,Surgery ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
43. ACCEPTABILITY OF BROAD CONSENT FOR THE USE AND RE-USE OF DONATED BLOOD SAMPLE AMONG WEST AFRICAN STROKE AND STROKE FREE INDIVIDUALS
- Author
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Olorunyomi Olorunsogbon, Joshua Akinyemi, Mayowa Ogunronbi, Muyiwa Adigun, Ezinne Uvere, Babatunde Ojebuyi, Michelle Nichol, Carolyn Jenkins, Mayowa Owolabi, Bruce Ovbiagele, Raj Kalaria, Oyedunni Arulogun, and Rufus Akinyemi
- Subjects
Rehabilitation ,Surgery ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
44. Stroke services, training, research and advocacy needs in Africa: Preliminary results from the Africa – UK Stroke Partnership (AUKSP) project
- Author
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Olaleye Adeniji, Stephanie Jones, Joseph Spencer, Gabriel Ogunde, Joseph Yaria, Pamela Naidoo, Foad Abdallah, Philip Adebayo, Paul Macaire Ossou-Nguiet, Dorcas Ogunloye, Jennifer Edwards, Liz Lightbody, Mayowa Owolabi, Caroline Watkins, and Rufus Akinyemi
- Subjects
Rehabilitation ,Surgery ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
45. COMMUNICATING ELSI ISSUES IN NEUROBIOBANKING AND STROKE GENOMIC RESEARCH IN AFRICA: PROJECT INTERVENTION TOOLS DEVELOPMENT AND EVALUATION PROCEDURES
- Author
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Babatunde R. Ojebuyi, Ibukun Afolami, Muyiwa Adigun, Arti Singh, Carolyn Jenkins, Michelle Nichols, Kolawole Wahab, Abiodun Bello, Fred S. Sarfo, Lukman F. Owolabi, Rabiu Musbahu, Reginald Obiako, Albert Akpalu, Mayowa Ogunronbi, Olorunyomi Olorunsogbon, Benedict Calys-Tagoe, Deborah Adesina, Nathaniel Coleman, Abdullateef G. Sule, Aliyu Mande, Muhammed Uthman, Musibau Titiloye, Ezinne Uvere, Odunola Bukola, Sylvia Melikam, Ruth Laryea, Adekunle Fakunle, Osi Adeleye, Nathaniel Mensah, Jibril Yusuf, Sunday Adeniyi, Shadrack Asibey, Lanre Omotoso, Lois Melikam, Dorcas Olujobi, Wisdom Oguike, Joshua Akinyemi, Ayodele Jegede, Rajesh Kalaria, Bruce Ovbiagele, Mayowa Owolabi, Oyedunni Arulogun, and Rufus Akinyemi
- Subjects
Rehabilitation ,Surgery ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
46. PREVALENCE AND RISK FACTORS OF STROKE RECURRENCE IN GHANA AND NIGERIA
- Author
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Osahon Jeffery Asowata, Fred Stephen Sarfo, Onoja Matthew Akpa, Joshua Akinyemi, Akinkunmi Paul Okekunle, Adekunle G. Fakunle, Godwin Ogbole, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe, Godwin Osaigbovo, Lukman Owolabi, Rufus Akinyemi, Mayowa Owolabi, and Bruce Ovbiagele
- Subjects
Rehabilitation ,Surgery ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
47. The Human Affectome
- Author
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Daniela Schiller, Alessandra Nicoletta Cruz Yu, Nelly Alia-Klein, Susanne Becker, Howard Casey Cromwell, Florin Dolcos, Paul J. Eslinger, Paul Frewen, Andrew Haddon Kemp, Edward Pace-Schott, Jacob Raber, Rebecca Levin Silton, Elka Stefanova, Justin H. G. Williams, Nobuhito Abe, Moji Aghajani, Franziska Albrecht, Rebecca Alexander, Silke Anders, Oriana R. Aragón, Juan A Arias, Shahar Arzy, Tatjana Aue, Sandra Baez, Michela Balconi, Tommaso Ballarini, Scott Bannister, Marlissa C. Amole, Karen Caplovitz Barrett, Catherine Belzung, Moustafa Bensafi, Linda Booij, Jamila Bookwala, Julie Boulanger-Bertolus, Sydney Weber Boutros, Anne-Kathrin Bräscher, Antonio Bruno, Geraldo Busatto, Lauren Bylsma, Catherine Caldwell-Harris, Raymond C. K. Chan, Nicolas Cherbuin, Julian Chiarella, Pietro Cipresso, HUgo Critchley, Denise Croote, Heath A. Demaree, Thomas F Denson, Brendan Depue, Birgit Dernt, Joanne M. Dickson, Sanda Dolcos, Anat Drach-Zahavy, Olga Dubljević, Tuomas Eerola, Dan-Mikael Ellingsen, Beth Fairfield, Camille Ferdenzi, Bruce H Scarpa-Friedman, Cynthia H.Y. Fu, Justine Gatt, Beatrice de Gelder, Guido H. E. Gendolla, Gadi Gilam, Hadass Goldblatt, Anne Kotynski, Olivia Gosseries, Alfons O. Hamm, Jamie Lars Hanson, Talma Hendler, Cornelia Herbert, Stefan G. Hofmann, Agustin Ibanez, Mateus Joffily, Tanja Jovanovic, Ian J. Kahrilas, Maria Kangas, Yuta Katsumi, Elizabeth Kensinger, Lauren A. J. Kirby, Rebecca Koncz, Ernst H. W. Koster, Kasia Kozlowska, Sören Krach, Mariska Kret, Martin Krippl, Kwabena Kusi-Mensah, Cecile D. Ladouceur, Steven Laureys, Alistair Lawrence, Chiang-Shan R. Li, Belinda Liddell, Navdeep K. Lidhar, Christopher A. Lowry, Kelsey Magee, Marie-France Marin, Veronica Mariotti, Loren Martin, Hilary A. Marusak, Annalina V. Mayer, Amanda R. Merner, Jessica Minnier, Jorge Moll, Robert Morrison, Matthew Moore, Anne-Marie Mouly, Sven C Mueller, Andreas Mühlberger, Nora A. Murphy, Maria Rosaria Anna Muscatello, Erica D. Musser, Tamara L. Newton, Michael Noll-Hussong, Seth Davin Norrholm, Georg Northoff, Robin Nusslock, Hadas Okon-Singer, Thomas M Olino, Catherine Nicole Marie Ortner, Mayowa Owolabi, Caterina Padulo, Romina Palermo, Rocco Palumbo, Sara Palumbo, Christos Papadelis, Alan J. Pegna, Silvia Pellegrini, Kirsi Peltonen, Brenda Penninx, Pietro Pietrini, Graziano Pinna, Rosario Pintos Lobo, Kelly L Polnaszek, Maryna Polyakova, Christine Rabinak, S. Helene Richter, Thalia Richter, Giuseppe Riva, Amelia Rizzo, Jennifer L. Robinson, Pedro Rosa, Perminder S Sachdev, Wataru Satomi, Matthias L. Schroeter, Susanne Schweizer, Youssef Shiban, Advaith Siddharthan, Ewa Siedlecka, Robert C. Smith, Hermona Soreq, Derek P. Spangler, Emily R. Stern, Charis Styliadis, Gavin Brent Sullivan, James E. Swain, Sébastien Urben, Jan Van den Stock, Michael A. van der Kooij, Mark van Overveld, Tamsyn Van Rheenen, Michael B. VanElzakker, Carlos Ventura-Bort, Edelyn Verona, Tyler Volk, Yi Wang, Leah T. Weingast, Mathias Weymar, Claire Williams, Megan Willis, Paula Yamashita, Roland Zahn, Barbra Zupan, and Leroy Lowe
- Abstract
We present here a unifying framework for affective phenomena: the Human Affectome. By synthesizing a large body of literature, we have converged on definitions that disambiguate the commonly used terms—affect, feeling, emotion, and mood. Based on this definitional foundation, and under the premise that affective states reflect allostatic concerns, we take a goal-directed, enactive perspective. The human affectome is comprised of allostatic features (valence, motivation, and arousal) and allostatic concerns, which differ in the amount of action required to alleviate allostatic load. Allostatic concerns often fall into three ranges: physiological (the most immediate), operational (intermediate to distal), and global. Global concerns involve summations of overall trajectory, general wellbeing, and self-identity. Within this organizational scheme, the human affectome allows vastly different scientific interests to reside within the same theoretical framework and relate to each other. We hope this framework serves as a common focal point for affective research.
- Published
- 2022
48. Polygenic risk scores for CARDINAL study
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Clement A. Adebamowo, Adebowale Adeyemo, Adeyinka Ashaye, Onoja M. Akpa, Tinashe Chikowore, Ananyo Choudhury, Yasmina J. Fakim, Segun Fatumo, Neil Hanchard, Michael Hauser, Braxton Mitchell, Nicola Mulder, Solomon F. Ofori-Acquah, Mayowa Owolabi, Michèle Ramsay, Bamidele Tayo, Archana Bhavani VasanthKumar, Yuji Zhang, and Sally N. Adebamowo
- Subjects
Multifactorial Inheritance ,Risk Factors ,Genetics ,Humans ,Genetic Predisposition to Disease ,Article ,Genome-Wide Association Study - Abstract
The Cardiometabolic Disorders in African-Ancestry Populations (CARDINAL) study site is a well-powered, first-of-its-kind resource for developing, refining and validating methods for research into polygenic risk scores that accounts for local ancestry, to improve risk prediction in diverse populations.
- Published
- 2022
49. Are there differences in perceptions, preferences and attitudes towards disclosure of genetic testing for Stroke? A qualitative study among stroke-free SIREN-SIBS genomics study participants
- Author
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Oyedunni Arulogun, Michelle Nichols, Carolyn Jenkins, Adekunle Gregory Fakunle, Onoja Akpa, Fred S. Sarfo, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe, Lukman Owolabi, Godwin O. Osaigbovo, Akinkunmi Paul Okekunle, Joshua Akinyemi, Godwin Ogbole, Benedict Calys-Tagoe, Adeniji Adeleye, Yaw Mensah, Osahon Jeffery Asowata, Abiodun M. Adeoye, Lambert Appiah, Arti Singh, Philip Adebayo, Donna Arnett, Hemant K. Tiwari, Daniel Lackland, Philip Ibinaiye, Wisdom Oguike, Chimdinma Melikam, Adeniyi Sunday, Abiodun Bello, Okechukwu Ogah, Rufus Akinyemi, Bruce Ovbiagele, and Mayowa Owolabi
- Subjects
Rehabilitation ,Surgery ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine - Published
- 2023
50. Digital Health in Primordial and Primary Stroke Prevention: A Systematic Review
- Author
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Valery L. Feigin, Mayowa Owolabi, Graeme J. Hankey, Jeyaraj Pandian, and Sheila C. Martins
- Subjects
Advanced and Specialized Nursing ,Primary Prevention ,Stroke ,Internet ,Humans ,Neurology (clinical) ,Smartphone ,Cardiology and Cardiovascular Medicine - Abstract
The stroke burden continues to grow across the globe, disproportionally affecting developing countries. This burden cannot be effectively halted and reversed without effective and widely implemented primordial and primary stroke prevention measures, including those on the individual level. The unprecedented growth of smartphone and other digital technologies with digital solutions are now being used in almost every area of health, offering a unique opportunity to improve primordial and primary stroke prevention on the individual level. However, there are several issues that need to be considered to advance development and use this important digital strategy for primordial and primary stroke prevention. Using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines we provide a systematic review of the current knowledge, challenges, and opportunities of digital health in primordial and primary stroke prevention.
- Published
- 2022
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