2,357 results on '"Mayer, Stephan A."'
Search Results
2. Critical Care of Spinal Cord Injury
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Zeller, Sabrina L., Stein, Alan, Frid, Ilya, Carpenter, Austin B., Soldozy, Sauson, Rawanduzy, Cameron, Rosenberg, Jon, Bauerschmidt, Andrew, Al-Mufti, Fawaz, Mayer, Stephan A., Kinon, Merritt D., and Wainwright, John V.
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- 2024
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3. Sex Differences in Perihematomal Edema Volume and Outcome After Intracerebral Hemorrhage
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Witsch, Jens, Cao, Quy, Song, Jae W., Luo, Yunshi, Sloane, Kelly L., Rothstein, Aaron, Favilla, Christopher G., Cucchiara, Brett L., Kasner, Scott E., Messé, Steve R., Choi, Huimahn A., McCullough, Louise D., Mayer, Stephan A., and Gusdon, Aaron M.
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- 2024
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4. Research considerations for prospective studies of patients with coma and disorders of consciousness
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Tinti, Lorenzo, Lawson, Thomas, Molteni, Erika, Kondziella, Daniel, Rass, Verena, Sharshar, Tarek, Bodien, Yelena G, Giacino, Joseph T, Mayer, Stephan A, Amiri, Moshgan, Muehlschlegel, Susanne, Rao, Chethan P Venkatasubba, Vespa, Paul M, Menon, David K, Citerio, Giuseppe, Helbok, Raimund, McNett, Molly, Agarwal, Sachin, Aiyagari, Venkatesh, Akbari, Yama, Albertson, Asher, Alexander, Sheila, Alexandrov, Anne, Alkhachroum, Ayham, Al-Mufti, Fawaz, Amiri, Moshagan, Appavu, Brian, Gebrewold, Meron Awraris, Ayounb, Marc, Badenes, Rafael, Bader, Mary Kay, Badjiata, Neeraj, Balu, Ram, Barlow, Brooke, Barra, Megan, Beekman, Rachel, Beghi, Ettore, Beqiri, Erta, Berlin, Tracey, Bilotta, Federico, Bleck, Thomas, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Bonnel, Alexandra, Brazzi, Luca, Brown, Emery, Bulic, Sebina, Caceres, Eder, Caceres, Adrian, Cafiero, Tullio, Carroll, Elizabeth, Cediel, Emilio G, Chou, Sherry, Claassen, Jan, Condie, Chad, Conti, Alfredo, Cosmas, Katie, Costa, Paolo, Creutzfeldt, Claire, Dangayach, Neha, Dauri, Mario, Debicki, Derek, DeGeorgia, Michael, Der-Nigoghossian, Caroline, Desai, Masoom, Dhar, Rajat, Diringer, Michael, Durr, Emily, Edlow, Brian, Ercole, Ari, Estraneo, Anna, Falcone, Guido, Farrokh, Salia, Ferguson, Adam, Fernandez-Espejo, Davinia, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Franchi, Federico, Frontera, Jennifer, Ganesan, Rishi, Gaspard, Nicolas, Ghavam, Ahmeneh, Giacino, Joseph, Gibbons, Christie, Gilmore, Emily, Glustein, Chavie, Gosseries, Olivia, Green, Theresa, Greer, David, Guanci, Mary, Gupta, Deepak, Hahn, Cecil, Hakimi, Ryan, Hammond, Flora, Hanley, Daniel F, Hartings, Jed, and Hassan, Ahmed
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Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Neurosciences ,Brain Disorders ,Prevention ,Curing Coma Campaign Collaborators ,coma ,design ,disorders of consciousness ,outcomes ,prospective studies ,Clinical sciences ,Biological psychology - Abstract
Disorders of consciousness are neurological conditions characterized by impaired arousal and awareness of self and environment. Behavioural responses are absent or are present but fluctuate. Disorders of consciousness are commonly encountered as a consequence of both acute and chronic brain injuries, yet reliable epidemiological estimates would require inclusive, operational definitions of the concept, as well as wider knowledge dissemination among involved professionals. Whereas several manifestations have been described, including coma, vegetative state/unresponsive wakefulness syndrome and minimally conscious state, a comprehensive neurobiological definition for disorders of consciousness is still lacking. The scientific literature is primarily observational, and studies-specific aetiologies lead to disorders of consciousness. Despite advances in these disease-related forms, there remains uncertainty about whether disorders of consciousness are a disease-agnostic unitary entity with a common mechanism, prognosis or treatment response paradigm. Our knowledge of disorders of consciousness has also been hampered by heterogeneity of study designs, variables, and outcomes, leading to results that are not comparable for evidence synthesis. The different backgrounds of professionals caring for patients with disorders of consciousness and the different goals at different stages of care could partly explain this variability. The Prospective Studies working group of the Neurocritical Care Society Curing Coma Campaign was established to create a platform for observational studies and future clinical trials on disorders of consciousness and coma across the continuum of care. In this narrative review, the author panel presents limitations of prior observational clinical research and outlines practical considerations for future investigations. A narrative review format was selected to ensure that the full breadth of study design considerations could be addressed and to facilitate a future consensus-based statement (e.g. via a modified Delphi) and series of recommendations. The panel convened weekly online meetings from October 2021 to December 2022. Research considerations addressed the nosographic status of disorders of consciousness, case ascertainment and verification, selection of dependent variables, choice of covariates and measurement and analysis of outcomes and covariates, aiming to promote more homogeneous designs and practices in future observational studies. The goal of this review is to inform a broad community of professionals with different backgrounds and clinical interests to address the methodological challenges imposed by the transition of care from acute to chronic stages and to streamline data gathering for patients with disorders of consciousness. A coordinated effort will be a key to allow reliable observational data synthesis and epidemiological estimates and ultimately inform condition-modifying clinical trials.
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- 2023
5. Perceived Utility of Intracranial Pressure Monitoring in Traumatic Brain Injury: A Seattle International Brain Injury Consensus Conference Consensus-Based Analysis and Recommendations.
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Chesnut, Randall, Aguilera, Sergio, Buki, Andras, Bulger, Eileen, Citerio, Giuseppe, Cooper, D, Arrastia, Ramon, Diringer, Michael, Figaji, Anthony, Gao, Guoyi, Geocadin, Romergryko, Ghajar, Jamshid, Harris, Odette, Hawryluk, Gregory, Hoffer, Alan, Hutchinson, Peter, Joseph, Mathew, Kitagawa, Ryan, Manley, Geoffrey, Mayer, Stephan, Menon, David, Meyfroidt, Geert, Michael, Daniel, Oddo, Mauro, Okonkwo, David, Patel, Mayur, Robertson, Claudia, Rosenfeld, Jeffrey, Rubiano, Andres, Sahuquillo, Juain, Servadei, Franco, Shutter, Lori, Stein, Deborah, Stocchetti, Nino, Taccone, Fabio, Timmons, Shelly, Tsai, Eve, Ullman, Jamie, Videtta, Walter, Wright, David, and Zammit, Christopher
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Humans ,Intracranial Pressure ,Brain Injuries ,Brain Injuries ,Traumatic ,Intracranial Hypertension ,Glasgow Coma Scale ,Monitoring ,Physiologic - Abstract
BACKGROUND: Intracranial pressure (ICP) monitoring is widely practiced, but the indications are incompletely developed, and guidelines are poorly followed. OBJECTIVE: To study the monitoring practices of an established expert panel (the clinical working group from the Seattle International Brain Injury Consensus Conference effort) to examine the match between monitoring guidelines and their clinical decision-making and offer guidance for clinicians considering monitor insertion. METHODS: We polled the 42 Seattle International Brain Injury Consensus Conference panel members ICP monitoring decisions for virtual patients, using matrices of presenting signs (Glasgow Coma Scale [GCS] total or GCS motor, pupillary examination, and computed tomography diagnosis). Monitor insertion decisions were yes, no, or unsure (traffic light approach). We analyzed their responses for weighting of the presenting signs in decision-making using univariate regression. RESULTS: Heatmaps constructed from the choices of 41 panel members revealed wider ICP monitor use than predicted by guidelines. Clinical examination (GCS) was by far the most important characteristic and differed from guidelines in being nonlinear. The modified Marshall computed tomography classification was second and pupils third. We constructed a heatmap and listed the main clinical determinants representing 80% ICP monitor insertion consensus for our recommendations. CONCLUSION: Candidacy for ICP monitoring exceeds published indicators for monitor insertion, suggesting the clinical perception that the value of ICP data is greater than simply detecting and monitoring severe intracranial hypertension. Monitor insertion heatmaps are offered as potential guidance for ICP monitor insertion and to stimulate research into what actually drives monitor insertion in unconstrained, real-world conditions.
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- 2023
6. Correction to: Code-ICH: A New Paradigm for Emergency Interventionn
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Yakhkind, Aleksandra, Yu, Wenzheng, Li, Qi, Goldstein, Joshua N., and Mayer, Stephan A.
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- 2024
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7. Speech Language Pathology in the Neurocritical Care Unit
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Frost, Nicole, Yuan, Gavin, Zhang, Julie, Rickard, Amy, McGee, Erin, DiMattia, Michelle, and Mayer, Stephan A.
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- 2023
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8. Correction to: Speech Language Pathology in the Neurocritical Care Unit
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Frost, Nicole, Yuan, Gavin, Zhang, Julia, Rickard, Amy, McGee, Erin, DiMattia, Michelle, and Mayer, Stephan A.
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- 2024
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9. Acute kidney injury in subarachnoid hemorrhage: Exploring its clinical significance and prognostic implications
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Subah, Galadu, Patel, Rohan, Nolan, Bridget, Fortunato, Michael, Lui, Aiden, Uddin, Anaz, Li, Austin, Spirollari, Eris, Nuoaman, Halla, Adnan, Yasir Ammar, Thomas, Anish, Brill, Stuart, Pak, Isaac, Ng, Christina, Hecht, Lee, Bauerschmidt, Andrew, Mayer, Stephan, Gandhi, Chirag D., and Al-Mufti, Fawaz
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- 2024
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10. Guidelines and standards for the study of death and recalled experiences of death––a multidisciplinary consensus statement and proposed future directions
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Parnia, Sam, Post, Stephen G, Lee, Matthew T, Lyubomirsky, Sonja, Aufderheide, Tom P, Deakin, Charles D, Greyson, Bruce, Long, Jeffrey, Gonzales, Anelly M, Huppert, Elise L, Dickinson, Analise, Mayer, Stephan, Locicero, Briana, Levin, Jeff, Bossis, Anthony, Worthington, Everett, Fenwick, Peter, and Shirazi, Tara Keshavarz
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Biomedical and Clinical Sciences ,Philosophy and Religious Studies ,Applied Ethics ,Cardiovascular ,Heart Disease ,Brain Disorders ,Neurosciences ,Brain ,Cardiopulmonary Resuscitation ,Consciousness ,Heart Arrest ,Humans ,Mental Recall ,death ,cardiac arrest ,resuscitation ,death by brain death criteria ,near-death experiences ,out-of-body experiences ,external visual awareness ,recalled experience of death (RED) coma ,cardiopulmonary resuscitation-induced consciousness ,post-intensive care syndrome ,General Science & Technology - Abstract
An inadvertent consequence of advances in stem cell research, neuroscience, and resuscitation science has been to enable scientific insights regarding what happens to the human brain in relation to death. The scientific exploration of death is in large part possible due to the recognition that brain cells are more resilient to the effects of anoxia than assumed. Hence, brain cells become irreversibly damaged and "die" over hours to days postmortem. Resuscitation science has enabled life to be restored to millions of people after their hearts had stopped. These survivors have described a unique set of recollections in relation to death that appear universal. We review the literature, with a focus on death, the recalled experiences in relation to cardiac arrest, post-intensive care syndrome, and related phenomena that provide insights into potential mechanisms, ethical implications, and methodologic considerations for systematic investigation. We also identify issues and controversies related to the study of consciousness and the recalled experience of cardiac arrest and death in subjects who have been in a coma, with a view to standardize and facilitate future research.
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- 2022
11. Ultra-Early Hemostatic Therapy for Acute Intracerebral Hemorrhage: An Updated Review
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Fortunato, Michael, Subah, Galadu, Thomas, Anish D., Nolan, Bridget, Mureb, Monica, Uddin, Anaz, Upadhyay, Kiran, Ogulnick, Jonathan V., Damodara, Nitesh, Bond, Colleen, Gandhi, Chirag D., Mayer, Stephan A., and Al-Mufti, Fawaz
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- 2024
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12. The REACT study: design of a randomized phase 3 trial to assess the efficacy and safety of clazosentan for preventing deterioration due to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage
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Bruder, Nicolas, Higashida, Randall, Santin-Janin, Hugues, Dubois, Cécile, Aldrich, E François, Marr, Angelina, Roux, Sébastien, and Mayer, Stephan A
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Biomedical and Clinical Sciences ,Clinical Sciences ,Neurosciences ,Clinical Trials and Supportive Activities ,Patient Safety ,Brain Disorders ,Clinical Research ,Stroke ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Good Health and Well Being ,Humans ,Subarachnoid Hemorrhage ,Prospective Studies ,Clinical Deterioration ,Quality of Life ,Vasospasm ,Intracranial ,Brain Ischemia ,Cerebral Infarction ,Aneurysm ,Subarachnoid hemorrhage ,Cerebral vasospasm ,Delayed cerebral ischemia ,Clazosentan ,Cognitive Sciences ,Neurology & Neurosurgery ,Clinical sciences - Abstract
BackgroundFor patients presenting with an aneurysmal subarachnoid hemorrhage (aSAH), delayed cerebral ischemia (DCI) is a significant cause of morbidity and mortality. The REACT study is designed to assess the safety and efficacy of clazosentan in preventing clinical deterioration due to DCI in patients with aSAH.MethodsREACT is a prospective, multicenter, randomized phase 3 study that is planned to enroll 400 patients with documented aSAH from a ruptured cerebral aneurysm, randomized 1:1 to 15 mg/hour intravenous clazosentan vs. placebo, in approximately 100 sites and 15 countries. Eligible patients are required to present at hospital admission with CT evidence of significant subarachnoid blood, defined as a thick and diffuse clot that is more than 4 mm in thickness and involves 3 or more basal cisterns. The primary efficacy endpoint is the occurrence of clinical deterioration due to DCI up to 14 days post-study drug initiation. The main secondary endpoint is the occurrence of clinically relevant cerebral infarction at Day 16 post-study drug initiation. Other secondary endpoints include the modified Rankin Scale (mRS) and the Glasgow Outcome Scale-Extended (GOSE) score at Week 12 post-aSAH, dichotomized into poor and good outcome. Radiological results and clinical endpoints are centrally evaluated by independent committees, blinded to treatment allocation. Exploratory efficacy endpoints comprise the assessment of cognition status at 12 weeks and quality of life at 12 and 24 weeks post aSAH.DiscussionIn the REACT study, clazosentan is evaluated on top of standard of care to determine if it reduces the risk of clinical deterioration due to DCI after aSAH. The selection of patients with thick and diffuse clots is intended to assess the benefit/risk profile of clazosentan in a population at high risk of vasospasm-related ischemic complications post-aSAH. TRIAL REGISTRATION (ADDITIONAL FILE 1): ClinicalTrials.gov (NCT03585270). EU Clinical Trial Register (EudraCT Number: 2018-000241-39).
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- 2022
13. Safety and Outcomes of Intravenous Thrombolytic Therapy in Ischemic Stroke Patients with COVID-19: CASCADE Initiative
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Sasanejad, Payam, Afshar Hezarkhani, Leila, Arsang-Jang, Shahram, Tsivgoulis, Georgios, Ghoreishi, Abdoreza, Barlinn, Kristian, Rahmig, Jan, Farhoudi, Mehdi, Sadeghi Hokmabadi, Elyar, Borhani-Haghighi, Afshin, Sariaslani, Payam, Sharifi-Razavi, Athena, Ghandehari, Kavian, Khosravi, Alireza, Smith, Craig, Nilanont, Yongchai, Akbari, Yama, Nguyen, Thanh N, Bersano, Anna, Yassi, Nawaf, Yoshimoto, Takeshi, Lattanzi, Simona, Gupta, Animesh, Zand, Ramin, Rafie, Shahram, Pourandokht Mousavian, Seyede, Reza Shahsavaripour, Mohammad, Amini, Shahram, Kamenova, Saltanat U, Kondybayeva, Aida, Zhanuzakov, Murat, Macri, Elizabeth M, Nobleza, Christa O'Hana S, Ruland, Sean, Cervantes-Arslanian, Anna M, Desai, Masoom J, Ranta, Annemarei, Moghadam Ahmadi, Amir, Rostamihosseinkhani, Mahtab, Foroughi, Razieh, Hooshmandi, Etrat, Akhoundi, Fahimeh H, Shuaib, Ashfaq, Liebeskind, David S, Siegler, James, Romano, Jose G, Mayer, Stephan A, Bavarsad Shahripour, Reza, Zamani, Babak, Woolsey, Amadene, Fazli, Yasaman, Mojtaba, Khazaei, Isaac, Christian F, Biller, Jose, Di Napoli, Mario, and Azarpazhooh, M Reza
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Biomedical and Clinical Sciences ,Clinical Sciences ,Neurosciences ,Stroke ,Brain Disorders ,Clinical Research ,Good Health and Well Being ,Aged ,Aged ,80 and over ,COVID-19 ,Disability Evaluation ,Europe ,Female ,Fibrinolytic Agents ,Hospital Mortality ,Humans ,Infusions ,Intravenous ,Intracranial Hemorrhages ,Iran ,Ischemic Stroke ,Male ,Middle Aged ,Risk Assessment ,Risk Factors ,Thrombolytic Therapy ,Time Factors ,Treatment Outcome ,COVID 19 ,Thrombolytic therapy ,Longitudinal study ,Safety ,Outcomes ,Disability ,Stroke severity ,death ,Neurology & Neurosurgery ,Clinical sciences - Abstract
BackgroundThere is little information regarding the safety of intravenous tissue plasminogen activator (IV-tPA) in patients with stroke and COVID-19.MethodsThis multicenter study included consecutive stroke patients with and without COVID-19 treated with IV-tPA between February 18, 2019, to December 31, 2020, at 9 centers participating in the CASCADE initiative. Clinical outcomes included modified Rankin Scale (mRS) at hospital discharge, in-hospital mortality, the rate of hemorrhagic transformation. Using Bayesian multiple regression and after adjusting for variables with significant value in univariable analysis, we reported the posterior adjusted odds ratio (OR, with 95% Credible Intervals [CrI]) of the main outcomes.ResultsA total of 545 stroke patients, including 101 patients with COVID-19 were evaluated. Patients with COVID-19 had a more severe stroke at admission. In the study cohort, 85 (15.9%) patients had a hemorrhagic transformation, and 72 (13.1%) died in the hospital. After adjustment for confounding variables, discharge mRS score ≥2 (OR: 0.73, 95% CrI: 0.16, 3.05), in-hospital mortality (OR: 2.06, 95% CrI: 0.76, 5.53), and hemorrhagic transformation (OR: 1.514, 95% CrI: 0.66, 3.31) were similar in COVID-19 and non COVID-19 patients. High-sensitivity C reactive protein level was a predictor of hemorrhagic transformation in all cases (OR:1.01, 95%CI: 1.0026, 1.018), including those with COVID-19 (OR:1.024, 95%CI:1.002, 1.054).ConclusionIV-tPA treatment in patients with acute ischemic stroke and COVID-19 was not associated with an increased risk of disability, mortality, and hemorrhagic transformation compared to those without COVID-19. IV-tPA should continue to be considered as the standard of care in patients with hyper acute stroke and COVID-19.
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- 2021
14. Code ICH: A Call to Action
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Li, Qi, Yakhkind, Aleksandra, Alexandrov, Anne W., Alexandrov, Andrei V., Anderson, Craig S., Dowlatshahi, Dar, Frontera, Jennifer A., Hemphill, J. Claude, Ganti, Latha, Kellner, Chris, May, Casey, Morotti, Andrea, Parry-Jones, Adrian, Sheth, Kevin N., Steiner, Thorsten, Ziai, Wendy, Goldstein, Joshua N., and Mayer, Stephan A.
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- 2024
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15. New-onset as opposed to established atrial fibrillation as a risk factor for incident stroke
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Aboul-Nour, Hassan, Jumah, Ammar, Schultz, Lonni, Affan, Muhammad, Gagi, Karam, Choudhury, Omar, Brady, Megan, Scozzari, Dawn, Nahab, Fadi, Miller, Daniel J., and Mayer, Stephan A.
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- 2024
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16. A Pilot Study of the Fluctuating Mental Status Evaluation: A Novel Delirium Screening Tool for Neurocritical Care Patients
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Reznik, Michael E., Margolis, Seth A., Moody, Scott, Drake, Jonathan, Tremont, Geoffrey, Furie, Karen L., Mayer, Stephan A., Ely, E. Wesley, and Jones, Richard N.
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- 2023
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17. Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.
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Claassen, Jan, Akbari, Yama, Alexander, Sheila, Bader, Mary Kay, Bell, Kathleen, Bleck, Thomas P, Boly, Melanie, Brown, Jeremy, Chou, Sherry H-Y, Diringer, Michael N, Edlow, Brian L, Foreman, Brandon, Giacino, Joseph T, Gosseries, Olivia, Green, Theresa, Greer, David M, Hanley, Daniel F, Hartings, Jed A, Helbok, Raimund, Hemphill, J Claude, Hinson, HE, Hirsch, Karen, Human, Theresa, James, Michael L, Ko, Nerissa, Kondziella, Daniel, Livesay, Sarah, Madden, Lori K, Mainali, Shraddha, Mayer, Stephan A, McCredie, Victoria, McNett, Molly M, Meyfroidt, Geert, Monti, Martin M, Muehlschlegel, Susanne, Murthy, Santosh, Nyquist, Paul, Olson, DaiWai M, Provencio, J Javier, Rosenthal, Eric, Sampaio Silva, Gisele, Sarasso, Simone, Schiff, Nicholas D, Sharshar, Tarek, Shutter, Lori, Stevens, Robert D, Vespa, Paul, Videtta, Walter, Wagner, Amy, Ziai, Wendy, Whyte, John, Zink, Elizabeth, Suarez, Jose I, and Curing Coma Campaign
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Curing Coma Campaign ,Biomarkers ,Coma ,Consciousness ,Electrophysiology ,Magnetic resonance imaging ,Clinical Sciences ,Neurosciences ,Neurology & Neurosurgery - Abstract
Coma and disorders of consciousness (DoC) are highly prevalent and constitute a burden for patients, families, and society worldwide. As part of the Curing Coma Campaign, the Neurocritical Care Society partnered with the National Institutes of Health to organize a symposium bringing together experts from all over the world to develop research targets for DoC. The conference was structured along six domains: (1) defining endotype/phenotypes, (2) biomarkers, (3) proof-of-concept clinical trials, (4) neuroprognostication, (5) long-term recovery, and (6) large datasets. This proceedings paper presents actionable research targets based on the presentations and discussions that occurred at the conference. We summarize the background, main research gaps, overall goals, the panel discussion of the approach, limitations and challenges, and deliverables that were identified.
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- 2021
18. Early tracheostomy in patients undergoing mechanical thrombectomy for acute ischemic stroke
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Shah, Smit, Spirollari, Eris, Ng, Christina, Cordeiro, Kevin, Clare, Kevin, Nolan, Bridget, Naftchi, Alexandria F., Carpenter, Austin B., Dominguez, Jose F., Kaplan, Ian, Bass, Brittany, Harper, Emily, Rosenberg, Jon, Chandy, Dipak, Mayer, Stephan A., Prabhakaran, Kartik, Wang, Arthur, Gandhi, Chirag D., and Al-Mufti, Fawaz
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- 2023
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19. Impact of pre-treatment cerebral microbleeds on the outcomes of endovascular thrombectomy: A systematic review and meta-analysis
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Elfil, Mohamed, Ghaith, Hazem S, Bayoumi, Ahmed, Elmashad, Ahmed, Aladawi, Mohammad, Al-Ani, Mina, Najdawi, Zaid, Mammadli, Gular, Russo, Brittany, Toth, Gabor, Nour, May, Asif, Kaiz, Nguyen, Thanh N, Gandhi, Chirag D, Kaur, Gurmeen, Hussain, M Shazam, Czap, Alexandra L, El-Ghanem, Mohammad, Mansour, Ossama Yassin, Khandelwal, Priyank, Mayer, Stephan, and Al-Mufti, Fawaz
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- 2023
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20. Exploring Hematoma Expansion Shift With Recombinant Factor VIIa: A Pooled Analysis of 4 Randomized Controlled Trials
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Yogendrakumar, Vignan, Mayer, Stephan A., Steiner, Thorsten, Broderick, Joseph P., and Dowlatshahi, Dar
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- 2023
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21. Significant increase in mortality and risk of acute ischemic stroke in infective endocarditis patients with subarachnoid hemorrhage secondary to mycotic aneurysms
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Sursal, Tolga, Clare, Kevin, Feldstein, Eric, Ogulnick, Jonathan, Nolan, Bridget, Karimov, Zafar, Nazarenko, Andrew, Ye, Linda, Bornovski, Yarden, Wong, Serena, Goldberg, Joshua, Mayer, Stephan A., Bauerschmidt, Andrew, El Khoury, Marc Y., Al-Jehani, Hosam, Gandhi, Chirag D., and Al-Mufti, Fawaz
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- 2023
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22. Stroke Care Trends During COVID-19 Pandemic in Zanjan Province, Iran. From the CASCADE Initiative: Statistical Analysis Plan and Preliminary Results
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Ghoreishi, Abdoreza, Arsang-Jang, Shahram, Sabaa-Ayoun, Ziad, Yassi, Nawaf, Sylaja, PN, Akbari, Yama, Divani, Afshin A, Biller, Jose, Phan, Thanh, Steinwender, Sandy, Silver, Brian, Zand, Ramin, Bin Basri, Hamidon, Iqbal, Omer M, Ranta, Annemarei, Ruland, Sean, Macri, Elizabeth, Ma, Henry, Nguyen, Thanh N, Abootalebi, Shahram, Gupta, Animesh, Alet, Matias, Lattanzi, Simona, Desai, Masoom, Gagliardi, Rubens J, Girotra, Tarun, Inoue, Manabu, Yoshimoto, Takeshi, Isaac, Cristian Flavo, Mayer, Stephan A, Morovatdar, Negar, Nilanont, Yongchai, Nobleza, Christa O'Hana S, Saber, Hamidreza, Kamenova, Saltanat, Kondybayeva, Aida, Krupinski, Jerzy, Siegler, James E, Stranges, Saverio, Torbey, Michel T, Yorio, Diana, Zurrú, María Cristina, Rubinos, Clio Aracelli, Shahripour, Reza Bavarsad, Borhani-Haghighi, Afshin, Di Napoli, Mario, and Azarpazhooh, M Reza
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Stroke ,Brain Disorders ,Neurosciences ,Patient Safety ,Health and social care services research ,8.1 Organisation and delivery of services ,Good Health and Well Being ,Aged ,Aged ,80 and over ,Bayes Theorem ,Brain Ischemia ,COVID-19 ,Female ,Hospital Mortality ,Hospitalization ,Humans ,Interrupted Time Series Analysis ,Intracranial Hemorrhages ,Iran ,Length of Stay ,Male ,Middle Aged ,Outcome and Process Assessment ,Health Care ,Recovery of Function ,Thrombolytic Therapy ,Time Factors ,Time-to-Treatment ,Treatment Outcome ,Epidemiology ,Outcome ,Mortality ,Disability ,Stroke care ,Clinical Sciences ,Neurology & Neurosurgery ,Clinical sciences - Abstract
BackgroundThe emergence of the COVID-19 pandemic has significantly impacted global healthcare systems and this may affect stroke care and outcomes. This study examines the changes in stroke epidemiology and care during the COVID-19 pandemic in Zanjan Province, Iran.MethodsThis study is part of the CASCADE international initiative. From February 18, 2019, to July 18, 2020, we followed ischemic and hemorrhagic stroke hospitalization rates and outcomes in Valiasr Hospital, Zanjan, Iran. We used a Bayesian hierarchical model and an interrupted time series analysis (ITS) to identify changes in stroke hospitalization rate, baseline stroke severity [measured by the National Institutes of Health Stroke Scale (NIHSS)], disability [measured by the modified Rankin Scale (mRS)], presentation time (last seen normal to hospital presentation), thrombolytic therapy rate, median door-to-needle time, length of hospital stay, and in-hospital mortality. We compared in-hospital mortality between study periods using Cox-regression model.ResultsDuring the study period, 1,026 stroke patients were hospitalized. Stroke hospitalization rates per 100,000 population decreased from 68.09 before the pandemic to 44.50 during the pandemic, with a significant decline in both Bayesian [Beta: -1.034; Standard Error (SE): 0.22, 95% CrI: -1.48, -0.59] and ITS analysis (estimate: -1.03, SE = 0.24, p
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- 2020
23. In Defense of Our Patients: Indirect Negative Neurological Consequences of SARS-CoV-2 in the New York Epicenter
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Cooper, Jared B, Amin, Anubhav G, Kim, Michael G, Stein, Alan A, Dominguez, Jose, Amuluru, Krishna, Tyagi, Rachana, Mayer, Stephan, Gandhi, Chirag D, and Al-Mufti, Fawaz
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Good Health and Well Being ,Adult ,Aged ,Betacoronavirus ,COVID-19 ,Cerebrovascular Disorders ,Coronavirus Infections ,Delivery of Health Care ,Integrated ,Disease Progression ,Emergencies ,Female ,Health Services Needs and Demand ,Host-Pathogen Interactions ,Humans ,Male ,Middle Aged ,New York City ,Pandemics ,Patient Acceptance of Health Care ,Patient Safety ,Pneumonia ,Viral ,Risk Assessment ,Risk Factors ,SARS-CoV-2 ,Time Factors ,Time-to-Treatment ,Coronavirus ,CoViD-19 ,Neurology & Neurosurgery ,Clinical sciences - Published
- 2020
24. The Curing Coma Campaign: Framing Initial Scientific Challenges—Proceedings of the First Curing Coma Campaign Scientific Advisory Council Meeting
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Provencio, J Javier, Hemphill, J Claude, Claassen, Jan, Edlow, Brian L, Helbok, Raimund, Vespa, Paul M, Diringer, Michael N, Polizzotto, Len, Shutter, Lori, Suarez, Jose I, Stevens, Robert D, Hanley, Daniel F, Akbari, Yama, Bleck, Thomas P, Boly, Melanie, Foreman, Brandon, Giacino, Joseph T, Hartings, Jed A, Human, Theresa, Kondziella, Daniel, Ling, Geoffrey SF, Mayer, Stephan A, McNett, Molly, Menon, David K, Meyfroidt, Geert, Monti, Martin M, Park, Soojin, Pouratian, Nader, Puybasset, Louis, Rohaut, Benjamin, Rosenthal, Eric S, Schiff, Nicholas D, Sharshar, Tarek, Wagner, Amy, Whyte, John, and Olson, DaiWai M
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Health Services and Systems ,Biomedical and Clinical Sciences ,Health Sciences ,Brain Disorders ,Good Health and Well Being ,Advisory Committees ,Biomarkers ,Clinical Trials as Topic ,Coma ,Consciousness Disorders ,Critical Care ,Humans ,Implementation Science ,Neurological Rehabilitation ,Neurology ,Proof of Concept Study ,Stakeholder Participation ,Endotype ,Biomarker ,Consciousness ,Recovery ,Neurocritical Care Society Curing Coma Campaign ,Clinical Sciences ,Neurosciences ,Neurology & Neurosurgery ,Clinical sciences ,Nursing - Abstract
Coma and disordered consciousness are common manifestations of acute neurological conditions and are among the most pervasive and challenging aspects of treatment in neurocritical care. Gaps exist in patient assessment, outcome prognostication, and treatment directed specifically at improving consciousness and cognitive recovery. In 2019, the Neurocritical Care Society (NCS) launched the Curing Coma Campaign in order to address the "grand challenge" of improving the management of patients with coma and decreased consciousness. One of the first steps was to bring together a Scientific Advisory Council including coma scientists, neurointensivists, neurorehabilitationists, and implementation experts in order to address the current scientific landscape and begin to develop a framework on how to move forward. This manuscript describes the proceedings of the first Curing Coma Campaign Scientific Advisory Council meeting which occurred in conjunction with the NCS Annual Meeting in October 2019 in Vancouver. Specifically, three major pillars were identified which should be considered: endotyping of coma and disorders of consciousness, biomarkers, and proof-of-concept clinical trials. Each is summarized with regard to current approach, benefits to the patient, family, and clinicians, and next steps. Integration of these three pillars will be essential to the success of the Curing Coma Campaign as will expanding the "curing coma community" to ensure broad participation of clinicians, scientists, and patient advocates with the goal of identifying and implementing treatments to fundamentally improve the outcome of patients.
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- 2020
25. A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC).
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Chesnut, Randall, Aguilera, Sergio, Buki, Andras, Bulger, Eileen, Citerio, Giuseppe, Cooper, D Jamie, Arrastia, Ramon Diaz, Diringer, Michael, Figaji, Anthony, Gao, Guoyi, Geocadin, Romer, Ghajar, Jamshid, Harris, Odette, Hoffer, Alan, Hutchinson, Peter, Joseph, Mathew, Kitagawa, Ryan, Manley, Geoffrey, Mayer, Stephan, Menon, David K, Meyfroidt, Geert, Michael, Daniel B, Oddo, Mauro, Okonkwo, David, Patel, Mayur, Robertson, Claudia, Rosenfeld, Jeffrey V, Rubiano, Andres M, Sahuquillo, Juan, Servadei, Franco, Shutter, Lori, Stein, Deborah, Stocchetti, Nino, Taccone, Fabio Silvio, Timmons, Shelly, Tsai, Eve, Ullman, Jamie S, Vespa, Paul, Videtta, Walter, Wright, David W, Zammit, Christopher, and Hawryluk, Gregory WJ
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Algorithm ,Brain injury ,Brain oxygen ,Consensus ,Head trauma ,Intracranial pressure ,PbtO2 ,Protocol ,SIBICC ,Seattle ,Tiers ,Emergency & Critical Care Medicine ,Clinical Sciences ,Public Health and Health Services - Abstract
BackgroundCurrent guidelines for the treatment of adult severe traumatic brain injury (sTBI) consist of high-quality evidence reports, but they are no longer accompanied by management protocols, as these require expert opinion to bridge the gap between published evidence and patient care. We aimed to establish a modern sTBI protocol for adult patients with both intracranial pressure (ICP) and brain oxygen monitors in place.MethodsOur consensus working group consisted of 42 experienced and actively practicing sTBI opinion leaders from six continents. Having previously established a protocol for the treatment of patients with ICP monitoring alone, we addressed patients who have a brain oxygen monitor in addition to an ICP monitor. The management protocols were developed through a Delphi-method-based consensus approach and were finalized at an in-person meeting.ResultsWe established three distinct treatment protocols, each with three tiers whereby higher tiers involve therapies with higher risk. One protocol addresses the management of ICP elevation when brain oxygenation is normal. A second addresses management of brain hypoxia with normal ICP. The third protocol addresses the situation when both intracranial hypertension and brain hypoxia are present. The panel considered issues pertaining to blood transfusion and ventilator management when designing the different algorithms.ConclusionsThese protocols are intended to assist clinicians in the management of patients with both ICP and brain oxygen monitors but they do not reflect either a standard-of-care or a substitute for thoughtful individualized management. These protocols should be used in conjunction with recommendations for basic care, management of critical neuroworsening and weaning treatment recently published in conjunction with the Seattle International Brain Injury Consensus Conference.
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- 2020
26. Manipulating temperature: devices for targeted temperature management (TTM) in brain injury
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Taccone, Fabio S., Donadello, Katia, and Mayer, Stephan A.
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Brain -- Injuries ,Medical colleges ,Hospital patients -- Injuries ,Company business management ,Health care industry - Abstract
Author(s): Fabio S. Taccone [sup.1] [sup.3], Katia Donadello [sup.2], Stephan A. Mayer [sup.3] Author Affiliations: (1) grid.4989.c, 0000 0001 2348 0746, Department of Intensive Care, Hôpital Universitare de Bruxelles (HUB), [...]
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- 2022
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27. A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC).
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Hawryluk, Gregory WJ, Aguilera, Sergio, Buki, Andras, Bulger, Eileen, Citerio, Giuseppe, Cooper, D Jamie, Arrastia, Ramon Diaz, Diringer, Michael, Figaji, Anthony, Gao, Guoyi, Geocadin, Romergryko, Ghajar, Jamshid, Harris, Odette, Hoffer, Alan, Hutchinson, Peter, Joseph, Mathew, Kitagawa, Ryan, Manley, Geoffrey, Mayer, Stephan, Menon, David K, Meyfroidt, Geert, Michael, Daniel B, Oddo, Mauro, Okonkwo, David, Patel, Mayur, Robertson, Claudia, Rosenfeld, Jeffrey V, Rubiano, Andres M, Sahuquillo, Juan, Servadei, Franco, Shutter, Lori, Stein, Deborah, Stocchetti, Nino, Taccone, Fabio Silvio, Timmons, Shelly, Tsai, Eve, Ullman, Jamie S, Vespa, Paul, Videtta, Walter, Wright, David W, Zammit, Christopher, and Chesnut, Randall M
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Humans ,Intracranial Hypertension ,Monitoring ,Physiologic ,Algorithms ,Adult ,Aged ,Aged ,80 and over ,Middle Aged ,Female ,Male ,Consensus Development Conferences as Topic ,Practice Guidelines as Topic ,Brain Injuries ,Traumatic ,Algorithm ,Brain injury ,Consensus ,Head trauma ,Intracranial pressure ,Protocol ,SIBICC ,Seattle ,Tiers ,Traumatic Brain Injury (TBI) ,Neurosciences ,Traumatic Head and Spine Injury ,Brain Disorders ,Physical Injury - Accidents and Adverse Effects ,Clinical Sciences ,Public Health and Health Services ,Emergency & Critical Care Medicine - Abstract
BackgroundManagement algorithms for adult severe traumatic brain injury (sTBI) were omitted in later editions of the Brain Trauma Foundation's sTBI Management Guidelines, as they were not evidence-based.MethodsWe used a Delphi-method-based consensus approach to address management of sTBI patients undergoing intracranial pressure (ICP) monitoring. Forty-two experienced, clinically active sTBI specialists from six continents comprised the panel. Eight surveys iterated queries and comments. An in-person meeting included whole- and small-group discussions and blinded voting. Consensus required 80% agreement. We developed heatmaps based on a traffic-light model where panelists' decision tendencies were the focus of recommendations.ResultsWe provide comprehensive algorithms for ICP-monitor-based adult sTBI management. Consensus established 18 interventions as fundamental and ten treatments not to be used. We provide a three-tier algorithm for treating elevated ICP. Treatments within a tier are considered empirically equivalent. Higher tiers involve higher risk therapies. Tiers 1, 2, and 3 include 10, 4, and 3 interventions, respectively. We include inter-tier considerations, and recommendations for critical neuroworsening to assist the recognition and treatment of declining patients. Novel elements include guidance for autoregulation-based ICP treatment based on MAP Challenge results, and two heatmaps to guide (1) ICP-monitor removal and (2) consideration of sedation holidays for neurological examination.ConclusionsOur modern and comprehensive sTBI-management protocol is designed to assist clinicians managing sTBI patients monitored with ICP-monitors alone. Consensus-based (class III evidence), it provides management recommendations based on combined expert opinion. It reflects neither a standard-of-care nor a substitute for thoughtful individualized management.
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- 2019
28. Frailty and outcomes in lacunar stroke
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Vazquez, Sima, Stadlan, Zehavya, Lapow, Justin M, Feldstein, Eric, Shah, Smit, Das, Ankita, Naftchi, Alexandria F, Spirollari, Eris, Thaker, Akash, Kazim, Syed Faraz, Dominguez, Jose F, Patel, Neisha, Kurian, Christeena, Chong, Ji, Mayer, Stephan A, Kaur, Gurmeen, Gandhi, Chirag D, Bowers, Christian A, and Al-Mufti, Fawaz
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- 2023
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29. Through the Looking Glass: The Paradoxical Evolution of Targeted Temperature Management for Comatose Survivors of Cardiac Arrest
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D’Amato, Salvatore A., Kimberly, W. Taylor, and Mayer, Stephan A.
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- 2022
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30. The Curing Coma Campaign International Survey on Coma Epidemiology, Evaluation, and Therapy (COME TOGETHER)
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Helbok, Raimund, Rass, Verena, Beghi, Ettore, Bodien, Yelena G., Citerio, Giuseppe, Giacino, Joseph T., Kondziella, Daniel, Mayer, Stephan A., Menon, David, Sharshar, Tarek, Stevens, Robert D., Ulmer, Hanno, Venkatasubba Rao, Chethan P., Vespa, Paul, McNett, Molly, and Frontera, Jennifer
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- 2022
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31. Research considerations for prospective studies of patients with coma and disorders of consciousness
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Tinti, L, Lawson, T, Molteni, E, Kondziella, D, Rass, V, Sharshar, T, Bodien, Y, Giacino, J, Mayer, S, Amiri, M, Muehlschlegel, S, Venkatasubba Rao, C, Vespa, P, Menon, D, Citerio, G, Helbok, R, Mcnett, M, Agarwal, S, Aiyagari, V, Akbari, Y, Albertson, A, Alexander, S, Alexandrov, A, Alkhachroum, A, Al-Mufti, F, Appavu, B, Gebrewold, M, Ayounb, M, Badenes, R, Bader, M, Badjiata, N, Balu, R, Barlow, B, Barra, M, Beekman, R, Beghi, E, Beqiri, E, Berlin, T, Bilotta, F, Bleck, T, Boerwinkle, V, Boly, M, Bonnel, A, Brazzi, L, Brown, E, Bulic, S, Caceres, E, Caceres, A, Cafiero, T, Carroll, E, Cediel, E, Chou, S, Claassen, J, Condie, C, Conti, A, Cosmas, K, Costa, P, Creutzfeldt, C, Dangayach, N, Dauri, M, Debicki, D, Degeorgia, M, Der-Nigoghossian, C, Desai, M, Dhar, R, Diringer, M, Durr, E, Edlow, B, Ercole, A, Estraneo, A, Falcone, G, Farrokh, S, Ferguson, A, Fernandez-Espejo, D, Fink, E, Fins, J, Foreman, B, Franchi, F, Frontera, J, Ganesan, R, Gaspard, N, Ghavam, A, Gibbons, C, Gilmore, E, Glustein, C, Gosseries, O, Green, T, Greer, D, Guanci, M, Gupta, D, Hahn, C, Hakimi, R, Hammond, F, Hanley, D, Hartings, J, Hassan, A, Hemphill, C, Da Cunha, A, Hinson, H, Hirsch, K, Hocker, S, Hu, P, Hu, X, Human, T, Hwang, D, Illes, J, Jaffa, M, James, M, Janas, A, Johnson, S, Jones, M, Jox, R, Kalanuria, A, Keller, E, Kennedy, L, Kennelly, M, Keogh, M, Kim, J, Kim, K, Kirsch, H, Kirschen, M, Ko, N, Kreitzer, N, Kromm, J, Kumar, A, Kurtz, P, Laureys, S, Lejeune, N, Lewis, A, Liang, J, Ling, G, Livesay, S, Luppi, A, Macdonald, J, Maddux, C, Mahanes, D, Mainali, S, Maldonado, N, Ribeiro, R, Mascia, L, Massimini, M, Mathur, R, Mccredie, V, Mejia-Mantilla, J, Mendoza, M, Meyfroidt, G, Mijangos, J, Moberg, D, Moheet, A, Montalenti, E, Monti, M, Morrison, C, Munar, M, Murtaugh, B, Naccache, L, Nagayama, M, Nairon, E, Nakagawa, T, Naldi, A, Narenthiran, G, Natarajan, G, Nemetsky, E, Newcombe, V, Nielsen, N, Niznick, N, Noronha-Falcão, F, Nyquist, P, Olson, D, Othman, M, Owen, A, Padayachy, L, Pajoumand, M, Park, S, Pergakis, M, Perry, H, Polizzotto, L, Pouratian, N, Spivack, M, Prisco, L, Provencio, J, Puglises, F, Puybasset, L, Rao, C, Rasmussen, L, Rasulo, F, Ray, B, Ricci, Z, Richardson, R, Shinotsuka, C, Robba, C, Robertson, C, Rohaut, B, Rolston, J, Romagnoli, S, Rosanova, M, Rosenthal, E, Rowe, S, Rubin, M, Russell, M, Silva, G, Sanz, L, Sarasso, S, Sarwal, A, Schiff, N, Schnakers, C, Seder, D, Shah, V, Shapiro-Rosenbaubm, A, Shapshak, A, Sharma, K, Shutter, L, Sitt, J, Slomine, B, Smetana, K, Smielewski, P, Smith, W, Stamatakis, E, Steinberg, A, Stevens, R, Suarez, J, Sung, G, Sussman, B, Taran, S, Mazzeo, A, Thibaut, A, Thompson, D, Threlkeld, Z, Toker, D, Torbey, M, Tosto, J, Trevick, S, Tsaousi, G, Turgeon, A, Udy, A, Varelas, P, Videtta, W, Voss, H, Vox, F, Wagner, A, Wahlster, S, Wainwright, M, Whyte, J, Witherspoon, B, Yakhkind, A, Yeager, S, Young, M, Zafar, S, Zafonte, R, Zahuranec, D, Zammit, C, Zhang, B, Ziai, W, Zimmerman, L, Zink, E, Tinti, Lorenzo, Lawson, Thomas, Molteni, Erika, Kondziella, Daniel, Rass, Verena, Sharshar, Tarek, Bodien, Yelena G, Giacino, Joseph T, Mayer, Stephan A, Amiri, Moshgan, Muehlschlegel, Susanne, Venkatasubba Rao, Chethan P, Vespa, Paul M, Menon, David K, Citerio, Giuseppe, Helbok, Raimund, McNett, Molly, Agarwal, Sachin, Aiyagari, Venkatesh, Akbari, Yama, Albertson, Asher, Alexander, Sheila, Alexandrov, Anne, Alkhachroum, Ayham, Al-Mufti, Fawaz, Amiri, Moshagan, Appavu, Brian, Gebrewold, Meron Awraris, Ayounb, Marc, Badenes, Rafael, Bader, Mary Kay, Badjiata, Neeraj, Balu, Ram, Barlow, Brooke, Barra, Megan, Beekman, Rachel, Beghi, Ettore, Beqiri, Erta, Berlin, Tracey, Bilotta, Federico, Bleck, Thomas, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Bonnel, Alexandra, Brazzi, Luca, Brown, Emery, Bulic, Sebina, Caceres, Eder, Caceres, Adrian, Cafiero, Tullio, Carroll, Elizabeth, Cediel, Emilio G, Chou, Sherry, Claassen, Jan, Condie, Chad, Conti, Alfredo, Cosmas, Katie, Costa, Paolo, Creutzfeldt, Claire, Dangayach, Neha, Dauri, Mario, Debicki, Derek, DeGeorgia, Michael, Der-Nigoghossian, Caroline, Desai, Masoom, Dhar, Rajat, Diringer, Michael, Durr, Emily, Edlow, Brian, Ercole, Ari, Estraneo, Anna, Falcone, Guido, Farrokh, Salia, Ferguson, Adam, Fernandez-Espejo, Davinia, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Franchi, Federico, Frontera, Jennifer, Ganesan, Rishi, Gaspard, Nicolas, Ghavam, Ahmeneh, Giacino, Joseph, Gibbons, Christie, Gilmore, Emily, Glustein, Chavie, Gosseries, Olivia, Green, Theresa, Greer, David, Guanci, Mary, Gupta, Deepak, Hahn, Cecil, Hakimi, Ryan, Hammond, Flora, Hanley, Daniel F, Hartings, Jed, Hassan, Ahmed, Hemphill, Claude, Da Cunha, Arthur Henrique Galvão Bruno, Hinson, Holly, Hirsch, Karen, Hocker, Sarah, Hu, Peter, Hu, Xiao, Human, Theresa, Hwang, David, Illes, Judy, Jaffa, Matthew, James, Michael L, Janas, Anna, Johnson, Susan, Jones, Morgan, Jox, Ralf J, Kalanuria, Atul, Keller, Emanuela, Kennedy, Lori, Kennelly, Megan, Keogh, Maggie, Kim, Jenn, Kim, Keri, Kirsch, Hannah, Kirschen, Matthew, Ko, Nerissa, Kreitzer, Natalie, Kromm, Julie, Kumar, Abhay, Kurtz, Pedro, Laureys, Steven, Lejeune, Nicolas, Lewis, Ariane, Liang, John, Ling, Geoffrey, Livesay, Sarah, Luppi, Andrea, MacDonald, Jennifer, Maddux, Craig, Mahanes, Dea, Mainali, Shraddha, Maldonado, Nelson, Ribeiro, Rennan Martins, Mascia, Luciana, Massimini, Marcello, Mathur, Rohan, Mayer, Stephan, McCredie, Victoria, Mejia-Mantilla, Jorge, Mendoza, Michael, Menon, David, Meyfroidt, Geert, Mijangos, Julio, Moberg, Dick, Moheet, Asma, Montalenti, Elisa, Monti, Martin, Morrison, Chris, Munar, Marina, Murtaugh, Brooke, Naccache, Lionel, Nagayama, Masao, Nairon, Emerson, Nakagawa, Thomas, Naldi, Andrea, Narenthiran, Ganesalingam, Natarajan, Girija, Nemetsky, Esther, Newcombe, Virginia, Nielsen, Niklas, Niznick, Naomi, Noronha-Falcão, Filipa, Nyquist, Paul, Olson, DaiWai, Othman, Marwan, Owen, Adrian, Padayachy, Llewellyn, Pajoumand, Mehrnaz, Park, Soojin, Pergakis, Melissa, Perry, Heidi, Polizzotto, Len, Pouratian, Nader, Spivack, Marilyn Price, Prisco, Lara, Provencio, Javier, Puglises, Francesco, Puybasset, Louis, Rao, Chethan, Rasmussen, Lindsay, Rasulo, Frank, Ray, Bappaditya, Ricci, Zaccaria, Richardson, Risa, Shinotsuka, Cassia Righy, Robba, Chiara, Robertson, Courtney, Rohaut, Benjamin, Rolston, John, Romagnoli, Stefano, Rosanova, Mario, Rosenthal, Eric, Rowe, Shaun, Rubin, Michael, Russell, Mary Beth, Silva, Gisele Sampaio, Sanz, Leandro, Sarasso, Simone, Sarwal, Aarti, Schiff, Nicolas, Schnakers, Caroline, Seder, David, Shah, Vishank Arun, Shapiro-Rosenbaubm, Amy, Shapshak, Angela, Sharma, Kartavya, Sharma, Kumar Ajay, Shutter, Lori, Sitt, Jacobo, Slomine, Beth, Smetana, Keaton, Smielewski, Peter, Smith, Wade, Stamatakis, Emmanuel, Steinberg, Alexis, Stevens, Robert, Suarez, Jose, Sung, Gene, Sussman, Bethany, Taran, Shaurya, Mazzeo, Anna Teresa, Thibaut, Aurore, Thompson, David, Threlkeld, Zachary, Toker, Daniel, Torbey, Michel, Tosto, Jenna, Trevick, Stephen, Tsaousi, Georgia, Turgeon, Alexis, Udy, Andrew, Varelas, Panos, Vespa, Paul, Videtta, Walter, Voss, Henning, Vox, Ford, Wagner, Amy, Wahlster, Sarah, Wainwright, Mark, Whyte, John, Witherspoon, Briana, Yakhkind, Aleksandra (Sasha), Yeager, Susan, Young, Michael, Zafar, Sahar, Zafonte, Ross, Zahuranec, Darin, Zammit, Chris, Zhang, Bei, Ziai, Wendy, Zimmerman, Lara, Zink, Elizabeth, Tinti, L, Lawson, T, Molteni, E, Kondziella, D, Rass, V, Sharshar, T, Bodien, Y, Giacino, J, Mayer, S, Amiri, M, Muehlschlegel, S, Venkatasubba Rao, C, Vespa, P, Menon, D, Citerio, G, Helbok, R, Mcnett, M, Agarwal, S, Aiyagari, V, Akbari, Y, Albertson, A, Alexander, S, Alexandrov, A, Alkhachroum, A, Al-Mufti, F, Appavu, B, Gebrewold, M, Ayounb, M, Badenes, R, Bader, M, Badjiata, N, Balu, R, Barlow, B, Barra, M, Beekman, R, Beghi, E, Beqiri, E, Berlin, T, Bilotta, F, Bleck, T, Boerwinkle, V, Boly, M, Bonnel, A, Brazzi, L, Brown, E, Bulic, S, Caceres, E, Caceres, A, Cafiero, T, Carroll, E, Cediel, E, Chou, S, Claassen, J, Condie, C, Conti, A, Cosmas, K, Costa, P, Creutzfeldt, C, Dangayach, N, Dauri, M, Debicki, D, Degeorgia, M, Der-Nigoghossian, C, Desai, M, Dhar, R, Diringer, M, Durr, E, Edlow, B, Ercole, A, Estraneo, A, Falcone, G, Farrokh, S, Ferguson, A, Fernandez-Espejo, D, Fink, E, Fins, J, Foreman, B, Franchi, F, Frontera, J, Ganesan, R, Gaspard, N, Ghavam, A, Gibbons, C, Gilmore, E, Glustein, C, Gosseries, O, Green, T, Greer, D, Guanci, M, Gupta, D, Hahn, C, Hakimi, R, Hammond, F, Hanley, D, Hartings, J, Hassan, A, Hemphill, C, Da Cunha, A, Hinson, H, Hirsch, K, Hocker, S, Hu, P, Hu, X, Human, T, Hwang, D, Illes, J, Jaffa, M, James, M, Janas, A, Johnson, S, Jones, M, Jox, R, Kalanuria, A, Keller, E, Kennedy, L, Kennelly, M, Keogh, M, Kim, J, Kim, K, Kirsch, H, Kirschen, M, Ko, N, Kreitzer, N, Kromm, J, Kumar, A, Kurtz, P, Laureys, S, Lejeune, N, Lewis, A, Liang, J, Ling, G, Livesay, S, Luppi, A, Macdonald, J, Maddux, C, Mahanes, D, Mainali, S, Maldonado, N, Ribeiro, R, Mascia, L, Massimini, M, Mathur, R, Mccredie, V, Mejia-Mantilla, J, Mendoza, M, Meyfroidt, G, Mijangos, J, Moberg, D, Moheet, A, Montalenti, E, Monti, M, Morrison, C, Munar, M, Murtaugh, B, Naccache, L, Nagayama, M, Nairon, E, Nakagawa, T, Naldi, A, Narenthiran, G, Natarajan, G, Nemetsky, E, Newcombe, V, Nielsen, N, Niznick, N, Noronha-Falcão, F, Nyquist, P, Olson, D, Othman, M, Owen, A, Padayachy, L, Pajoumand, M, Park, S, Pergakis, M, Perry, H, Polizzotto, L, Pouratian, N, Spivack, M, Prisco, L, Provencio, J, Puglises, F, Puybasset, L, Rao, C, Rasmussen, L, Rasulo, F, Ray, B, Ricci, Z, Richardson, R, Shinotsuka, C, Robba, C, Robertson, C, Rohaut, B, Rolston, J, Romagnoli, S, Rosanova, M, Rosenthal, E, Rowe, S, Rubin, M, Russell, M, Silva, G, Sanz, L, Sarasso, S, Sarwal, A, Schiff, N, Schnakers, C, Seder, D, Shah, V, Shapiro-Rosenbaubm, A, Shapshak, A, Sharma, K, Shutter, L, Sitt, J, Slomine, B, Smetana, K, Smielewski, P, Smith, W, Stamatakis, E, Steinberg, A, Stevens, R, Suarez, J, Sung, G, Sussman, B, Taran, S, Mazzeo, A, Thibaut, A, Thompson, D, Threlkeld, Z, Toker, D, Torbey, M, Tosto, J, Trevick, S, Tsaousi, G, Turgeon, A, Udy, A, Varelas, P, Videtta, W, Voss, H, Vox, F, Wagner, A, Wahlster, S, Wainwright, M, Whyte, J, Witherspoon, B, Yakhkind, A, Yeager, S, Young, M, Zafar, S, Zafonte, R, Zahuranec, D, Zammit, C, Zhang, B, Ziai, W, Zimmerman, L, Zink, E, Tinti, Lorenzo, Lawson, Thomas, Molteni, Erika, Kondziella, Daniel, Rass, Verena, Sharshar, Tarek, Bodien, Yelena G, Giacino, Joseph T, Mayer, Stephan A, Amiri, Moshgan, Muehlschlegel, Susanne, Venkatasubba Rao, Chethan P, Vespa, Paul M, Menon, David K, Citerio, Giuseppe, Helbok, Raimund, McNett, Molly, Agarwal, Sachin, Aiyagari, Venkatesh, Akbari, Yama, Albertson, Asher, Alexander, Sheila, Alexandrov, Anne, Alkhachroum, Ayham, Al-Mufti, Fawaz, Amiri, Moshagan, Appavu, Brian, Gebrewold, Meron Awraris, Ayounb, Marc, Badenes, Rafael, Bader, Mary Kay, Badjiata, Neeraj, Balu, Ram, Barlow, Brooke, Barra, Megan, Beekman, Rachel, Beghi, Ettore, Beqiri, Erta, Berlin, Tracey, Bilotta, Federico, Bleck, Thomas, Bodien, Yelena, Boerwinkle, Varina, Boly, Melanie, Bonnel, Alexandra, Brazzi, Luca, Brown, Emery, Bulic, Sebina, Caceres, Eder, Caceres, Adrian, Cafiero, Tullio, Carroll, Elizabeth, Cediel, Emilio G, Chou, Sherry, Claassen, Jan, Condie, Chad, Conti, Alfredo, Cosmas, Katie, Costa, Paolo, Creutzfeldt, Claire, Dangayach, Neha, Dauri, Mario, Debicki, Derek, DeGeorgia, Michael, Der-Nigoghossian, Caroline, Desai, Masoom, Dhar, Rajat, Diringer, Michael, Durr, Emily, Edlow, Brian, Ercole, Ari, Estraneo, Anna, Falcone, Guido, Farrokh, Salia, Ferguson, Adam, Fernandez-Espejo, Davinia, Fink, Ericka, Fins, Joseph, Foreman, Brandon, Franchi, Federico, Frontera, Jennifer, Ganesan, Rishi, Gaspard, Nicolas, Ghavam, Ahmeneh, Giacino, Joseph, Gibbons, Christie, Gilmore, Emily, Glustein, Chavie, Gosseries, Olivia, Green, Theresa, Greer, David, Guanci, Mary, Gupta, Deepak, Hahn, Cecil, Hakimi, Ryan, Hammond, Flora, Hanley, Daniel F, Hartings, Jed, Hassan, Ahmed, Hemphill, Claude, Da Cunha, Arthur Henrique Galvão Bruno, Hinson, Holly, Hirsch, Karen, Hocker, Sarah, Hu, Peter, Hu, Xiao, Human, Theresa, Hwang, David, Illes, Judy, Jaffa, Matthew, James, Michael L, Janas, Anna, Johnson, Susan, Jones, Morgan, Jox, Ralf J, Kalanuria, Atul, Keller, Emanuela, Kennedy, Lori, Kennelly, Megan, Keogh, Maggie, Kim, Jenn, Kim, Keri, Kirsch, Hannah, Kirschen, Matthew, Ko, Nerissa, Kreitzer, Natalie, Kromm, Julie, Kumar, Abhay, Kurtz, Pedro, Laureys, Steven, Lejeune, Nicolas, Lewis, Ariane, Liang, John, Ling, Geoffrey, Livesay, Sarah, Luppi, Andrea, MacDonald, Jennifer, Maddux, Craig, Mahanes, Dea, Mainali, Shraddha, Maldonado, Nelson, Ribeiro, Rennan Martins, Mascia, Luciana, Massimini, Marcello, Mathur, Rohan, Mayer, Stephan, McCredie, Victoria, Mejia-Mantilla, Jorge, Mendoza, Michael, Menon, David, Meyfroidt, Geert, Mijangos, Julio, Moberg, Dick, Moheet, Asma, Montalenti, Elisa, Monti, Martin, Morrison, Chris, Munar, Marina, Murtaugh, Brooke, Naccache, Lionel, Nagayama, Masao, Nairon, Emerson, Nakagawa, Thomas, Naldi, Andrea, Narenthiran, Ganesalingam, Natarajan, Girija, Nemetsky, Esther, Newcombe, Virginia, Nielsen, Niklas, Niznick, Naomi, Noronha-Falcão, Filipa, Nyquist, Paul, Olson, DaiWai, Othman, Marwan, Owen, Adrian, Padayachy, Llewellyn, Pajoumand, Mehrnaz, Park, Soojin, Pergakis, Melissa, Perry, Heidi, Polizzotto, Len, Pouratian, Nader, Spivack, Marilyn Price, Prisco, Lara, Provencio, Javier, Puglises, Francesco, Puybasset, Louis, Rao, Chethan, Rasmussen, Lindsay, Rasulo, Frank, Ray, Bappaditya, Ricci, Zaccaria, Richardson, Risa, Shinotsuka, Cassia Righy, Robba, Chiara, Robertson, Courtney, Rohaut, Benjamin, Rolston, John, Romagnoli, Stefano, Rosanova, Mario, Rosenthal, Eric, Rowe, Shaun, Rubin, Michael, Russell, Mary Beth, Silva, Gisele Sampaio, Sanz, Leandro, Sarasso, Simone, Sarwal, Aarti, Schiff, Nicolas, Schnakers, Caroline, Seder, David, Shah, Vishank Arun, Shapiro-Rosenbaubm, Amy, Shapshak, Angela, Sharma, Kartavya, Sharma, Kumar Ajay, Shutter, Lori, Sitt, Jacobo, Slomine, Beth, Smetana, Keaton, Smielewski, Peter, Smith, Wade, Stamatakis, Emmanuel, Steinberg, Alexis, Stevens, Robert, Suarez, Jose, Sung, Gene, Sussman, Bethany, Taran, Shaurya, Mazzeo, Anna Teresa, Thibaut, Aurore, Thompson, David, Threlkeld, Zachary, Toker, Daniel, Torbey, Michel, Tosto, Jenna, Trevick, Stephen, Tsaousi, Georgia, Turgeon, Alexis, Udy, Andrew, Varelas, Panos, Vespa, Paul, Videtta, Walter, Voss, Henning, Vox, Ford, Wagner, Amy, Wahlster, Sarah, Wainwright, Mark, Whyte, John, Witherspoon, Briana, Yakhkind, Aleksandra (Sasha), Yeager, Susan, Young, Michael, Zafar, Sahar, Zafonte, Ross, Zahuranec, Darin, Zammit, Chris, Zhang, Bei, Ziai, Wendy, Zimmerman, Lara, and Zink, Elizabeth
- Abstract
Disorders of consciousness are neurological conditions characterized by impaired arousal and awareness of self and environment. Behavioural responses are absent or are present but fluctuate. Disorders of consciousness are commonly encountered as a consequence of both acute and chronic brain injuries, yet reliable epidemiological estimates would require inclusive, operational definitions of the concept, as well as wider knowledge dissemination among involved professionals. Whereas several manifestations have been described, including coma, vegetative state/unresponsive wakefulness syndrome and minimally conscious state, a comprehensive neurobiological definition for disorders of consciousness is still lacking. The scientific literature is primarily observational, and studies-specific aetiologies lead to disorders of consciousness. Despite advances in these disease-related forms, there remains uncertainty about whether disorders of consciousness are a disease-agnostic unitary entity with a common mechanism, prognosis or treatment response paradigm. Our knowledge of disorders of consciousness has also been hampered by heterogeneity of study designs, variables, and outcomes, leading to results that are not comparable for evidence synthesis. The different backgrounds of professionals caring for patients with disorders of consciousness and the different goals at different stages of care could partly explain this variability. The Prospective Studies working group of the Neurocritical Care Society Curing Coma Campaign was established to create a platform for observational studies and future clinical trials on disorders of consciousness and coma across the continuum of care. In this narrative review, the author panel presents limitations of prior observational clinical research and outlines practical considerations for future investigations. A narrative review format was selected to ensure that the full breadth of study design considerations could be addressed and to facilit
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- 2024
32. Aneurysmal Subarachnoid Hemorrhage and Cardiac Related Fatality: Who Dies and Why?
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Khan, Farzana, Peyvandi, Forouhideh, Clare, Kevin, Nolan, Bridget, Patel, Smit, Feldstein, Eric, Ogulnick, Jonathan V., Said, Azhar, Zeller, Sabrina, Bornovski, Yarden, Wong, Serena, Medicherla, Chaitanya B., Rosenberg, Jon, Miller, Daniel, Coritsidis, George, Prabhakaran, Karthik, Mayer, Stephan A., Gandhi, Chirag D., and Al-Mufti, Fawaz
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- 2023
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33. Glucose Control and Risk of Symptomatic Intracerebral Hemorrhage Following Thrombolysis for Acute Ischemic Stroke
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Southerland, Andrew M., primary, Mayer, Stephan A., additional, Chiota-McCollum, Nicole A., additional, Bolte, Ashley C., additional, Pauls, Qi, additional, Pettigrew, L. Creed, additional, Bleck, Thomas P., additional, Conaway, Mark, additional, and Johnston, Karen C., additional
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- 2024
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34. Association Between Soluble Intercellular Adhesion Molecule-1 and Intracerebral Hemorrhage Outcomes in the FAST Trial
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Witsch, Jens, Roh, David, Oh, Stephanie, Iadecola, Costantino, Diaz-Arrastia, Ramon, Kasner, Scott E., Mayer, Stephan A., and Murthy, Santosh B.
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- 2023
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35. Significant Mortality Associated With COVID-19 and Comorbid Cerebrovascular Disease: A Quantitative Systematic Review
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Sursal, Tolga, Gandhi, Chirag D., Clare, Kevin, Feldstein, Eric, Frid, Ilya, Kefina, Martin, Galluzzo, Daniela, Kamal, Haris, Nuoman, Rolla, Amuluru, Krishna, Muh, Carrie R., Pisapia, Jared M., Gulko, Edwin, Overby, Philip, Chandy, Dipak, Etienne, Mill, Kurian, Christeena, Kaur, Gurmeen, Dakay, Katarina, AlHamid, May, Al-Jehani, Hosam, Mayer, Stephan A., and Al-Mufti, Fawaz
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- 2023
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36. Transcarotid Access for Mechanical Thrombectomy in Acute Ischemic Stroke: A Meta-Analysis and Systematic Review
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Zhong, Allison J., Kamal, Haris, Uddin, Anaz, Feldstein, Eric, Shapiro, Steven D., Chung, Joon Yong, Ogarro, Maziyah, Friedman, Rebecca, Simmons, Josh, Graifman, Gillian, Kurian, Christeena, Kaur, Gurmeen, Mayer, Stephan A., Chong, Ji, Gandhi, Chirag D., and Al-Mufti, Fawaz
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- 2022
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37. Safety and efficacy of a novel robotic transcranial doppler system in subarachnoid hemorrhage
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Clare, Kevin, Stein, Alan, Damodara, Nitesh, Feldstein, Eric, Alshammari, Hussein, Ali, Syed, Kurian, Christeena, Rosenberg, Jon, Bauerschmidt, Andrew, Kaur, Gurmeen, Santarelli, Justin, Hamilton, Robert, Mayer, Stephan, Gandhi, Chirag D., and Al-Mufti, Fawaz
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- 2022
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38. Intracranial Pressure Monitoring and Management
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Viarasilpa, Tanuwong, primary, Francoeur, Charles L, additional, and Mayer, Stephan A, additional
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- 2022
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39. Endovascular thrombectomy with and without preceding intravenous thrombolysis for treatment of large vessel anterior circulation stroke: A cross-sectional analysis of 50,000 patients
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Dicpinigaitis, Alis J., Gandhi, Chirag D., Shah, Smit P., Galea, Vincent P., Cooper, Jared B., Feldstein, Eric, Shapiro, Steven D., Kamal, Haris, Kurian, Christeena, Kaur, Gurmeen, Tyagi, Rachana, Biswas, Arundhati, Rosenberg, Jon, Bauerschmidt, Andrew, Bowers, Christian A., Mayer, Stephan A., and Al-Mufti, Fawaz
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- 2022
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40. Acute Myocardial Injury in Spontaneous Intracerebral Hemorrhage: A Secondary Observational Analysis of the FAST Trial.
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Rosso, Michela, Stengl, Helena, Scheitz, Jan F., Lewey, Jennifer, Mayer, Stephan A., Yaghi, Shadi, Kasner, Scott E., and Witsch, Jens
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- 2024
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41. Predictors of Outcomes and a Weighted Mortality Score for Moderate to Severe Subdural Hematoma.
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Vazquez, Sima, Jain, Aarti K., Nolan, Bridget, Spirollari, Eris, Clare, Kevin, Thomas, Anish, Soldozy, Sauson, Ali, Syed, Sukul, Vishad, Rosenberg, Jon, Mayer, Stephan, Khatri, Rakesh, Jankowitz, Brian T., Singer, Justin, Gandhi, Chirag, and Al-Mufti, Fawaz
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NOSOLOGY ,SUBDURAL hematoma ,GLASGOW Coma Scale ,HOSPITAL mortality ,ARTIFICIAL respiration - Abstract
As the incidence of subdural hematoma is increasing, it is important to understand symptomatology and clinical variables associated with treatment outcomes and mortality in this population; patients with subdural hematoma were selected from the National Inpatient Sample (NIS) Database between 2016 and 2020 using International Classification of Disease 10th Edition (ICD10) codes. Moderate-to-severe subdural hematoma patients were identified using the Glasgow Coma Scale (GCS). Multivariate regression was first used to identify predictors of in-hospital mortality and then beta coefficients were used to create a weighted mortality score. Of 29,915 patients admitted with moderate-to-severe subdural hematomas, 12,135 (40.6%) died within the same hospital admission. In a multivariate model of relevant demographic and clinical covariates, age greater than 70, diabetes mellitus, mechanical ventilation, hydrocephalus, and herniation were independent predictors of mortality (p < 0.001 for all). Age greater than 70, diabetes mellitus, mechanical ventilation, hydrocephalus, and herniation were assigned a "1" in a weighted mortality score. The ROC curve for our model showed an area under the curve of 0.64. Age greater than 70, diabetes mellitus, mechanical ventilation, hydrocephalus, and herniation were predictive of mortality. We created the first clinically relevant weighted mortality score that can be used to stratify risk, guide prognosis, and inform family discussions. [ABSTRACT FROM AUTHOR]
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- 2024
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42. Impact of pre-ictal antiplatelet therapy use in aneurysmal subarachnoid hemorrhage
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Al-Mufti, Fawaz, Ogulnick, Jonathan, Feldstein, Eric, Damodara, Nitesh, Bravo, Michelle, Alshammari, Hussein, Dominguez, Jose, Cooper, Jared, Huang, Kristen T., Marikunte, Sanjana, Ali, Syed, Patel, Vikas, Khandelwal, Priyank, Mayer, Stephan A., Amuluru, Krishna, and Gandhi, Chirag D.
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- 2021
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43. Relation between brain natriuretic peptide and delayed cerebral ischemia in patients with aneurysmalsubarachnoid hemorrhage
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Kaur, Gurmeen, Damodara, Nitesh, Feldstein, Eric, Dominguez, Jose, Huang, Kristen T., Ogulnick, Jonathan V., Nuoman, Rolla, Khandelwal, Priyank, El-Ghanem, Mohammad, Gupta, Gaurav, Mayer, Stephan A., Amuluru, Krishna, Gandhi, Chirag D., and Al-Mufti, Fawaz
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- 2021
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44. Outcomes of heparin-induced thrombocytopenia type II in aneurysmal subarachnoid hemorrhage patients: A US nationwide analysis
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Subah, Galadu, primary, Zeller, Sabrina, additional, Damodara, Nitesh, additional, Fortunato, Michael, additional, Garrett, Jenna, additional, Syed, Shoaib, additional, Uddin, Anaz, additional, Pak, Issac, additional, Feldstein, Eric, additional, Mayer, Stephan, additional, Gandhi, Chirag D, additional, and Al-Mufti, Fawaz, additional
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- 2024
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45. Mapping geographic disparities in treatment and clinical outcomes of high-grade aneurysmal subarachnoid hemorrhage in the United States
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Dicpinigaitis, Alis J, primary, Fortunato, Michael P, additional, Goyal, Anjali, additional, Syed, Shoaib A, additional, Patel, Rohan, additional, Subah, Galadu, additional, Rosenberg, Jon B, additional, Bowers, Christian A, additional, Mayer, Stephan A, additional, Jankowitz, Brian, additional, Gandhi, Chirag D, additional, and Al-Mufti, Fawaz, additional
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- 2024
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46. Investigating Outcomes Post–Endovascular Thrombectomy in Acute Stroke Patients With Cancer
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Shapiro, Steven D., Vazquez, Sima, Das, Ankita, Dominguez, Jose F., Kamal, Haris, Chong, Ji, Mayer, Stephan A., Kaur, Gurmeen, Gandhi, Chirag, and Al-Mufti, Fawaz
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- 2022
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47. Differentiation of psychogenic nonepileptic attacks from status epilepticus among patients intubated for convulsive activity
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Viarasilpa, Tanuwong, Panyavachiraporn, Nicha, Osman, Gamaleldin, Kowalski, Robert G., Miller, Joseph, Barkley, Gregory L., and Mayer, Stephan A.
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- 2021
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48. Results of the ICTuS 2 Trial (Intravascular Cooling in the Treatment of Stroke 2)
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Lyden, Patrick, Hemmen, Thomas, Grotta, James, Rapp, Karen, Ernstrom, Karin, Rzesiewicz, Teresa, Parker, Stephanie, Concha, Mauricio, Hussain, Syed, Agarwal, Sachin, Meyer, Brett, Jurf, Julie, Altafullah, Irfan, Raman, Rema, Hess, Mary Jane, Mullin, Anthony, Jane Hess, Mary, Muranevici, Gabriela, Piantadosi, Bonnie, Jimenez-Maggiora, Gustavo, So, Jia-Shing, Jain, Sonia, Diringer, Michael, Derdeyn, Colin, Stern, Barney, Hamilton, Scott, Dietrich, Dalton, Becker, Kyra, Yenari, Midori, Dirnagl, Ulrich, Wijman, Christine, Chamorro, Ángel, Janis, Scott, Moy, Claudia, Lin, Felice, Song, Shlee, Schlick, Konrad, Khanolkar, Pooja, Edwards, Nancy J, Roldan, Ana, Wilson, Jeanette, Little, Amy, Lewis, Pam, Neil, William, Bruce, Nhu, Guzik, Amy, Sohdi, Ajeet, Herial, Nabeel, Ovbiagele, Bruce, Meyer, Dawn, Modir, Royya, Chavez, Ronelyn, Velazquez, Angela, Mayer, Stephan, Claassen, Jan, Falo, Cristina, Tafreshi, Gilda, Kelly, Nancy, Shell, Erin, Dugan, Guy, Kim, Elizabeth, Tanner, Amy, Michel, Patrik, Eskandari, Ashraf, Oddo, Mauro, Suys, Tamarah, Remillard, Suzette, Cordier, Maria, Brown, Robert, Jasak, Sara, McCullough, Louise, Brautigam, Robert, Alexandrov, Andrei, Sisson, April, Albright, Karen, Broessner, Gregor, Schmutzhard, Erich, Escioglou, Elissanet, Jones, William, Poisson, Sharon, Simpson, Jennifer, Shah, Qaisar, Jonczak, Karin, Bussinger, Patricia, Lewandowski, Christopher, Berry, Shannen, Lundell, AnneMarie, Miller, Joseph B, Cruz-Flores, Salvador, Holzer, Eve, Torretta, Susan, Brown, David, Heim, Laura, and Smith, Carlos
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Biomedical and Clinical Sciences ,Clinical Sciences ,Stroke ,Clinical Trials and Supportive Activities ,Lung ,Brain Disorders ,Clinical Research ,Neurosciences ,Aged ,Aged ,80 and over ,Female ,Follow-Up Studies ,Humans ,Hypothermia ,Induced ,Male ,Middle Aged ,Outcome Assessment ,Health Care ,Single-Blind Method ,hypothermia ,intention to treat analysis ,ischemic stroke ,neuroprotection ,pneumonia ,stroke ,therapeutics ,Collaborators ,Cardiorespiratory Medicine and Haematology ,Neurology & Neurosurgery ,Clinical sciences ,Allied health and rehabilitation science - Abstract
Background and purposeTherapeutic hypothermia is a potent neuroprotectant approved for cerebral protection after neonatal hypoxia-ischemia and cardiac arrest. Therapeutic hypothermia for acute ischemic stroke is safe and feasible in pilot trials. We designed a study protocol to provide safer, faster therapeutic hypothermia in stroke patients.MethodsSafety procedures and 4°C saline infusions for faster cooling were added to the ICTuS trial (Intravascular Cooling in the Treatment of Stroke) protocol. A femoral venous intravascular cooling catheter after intravenous recombinant tissue-type plasminogen activator in eligible patients provided 24 hours cooling followed by a 12-hour rewarm. Serial safety assessments and imaging were performed. The primary end point was 3-month modified Rankin score 0,1.ResultsOf the intended 1600 subjects, 120 were enrolled before the study was stopped. Randomly, 63 were to receive hypothermia plus antishivering treatment and 57 normothermia. Compared with previous studies, cooling rates were improved with a cold saline bolus, without fluid overload. The intention-to-treat primary outcome of 90-day modified Rankin Score 0,1 occurred in 33% hypothermia and 38% normothermia subjects, odds ratio (95% confidence interval) of 0.81 (0.36-1.85). Serious adverse events occurred equally. Mortality was 15.9% hypothermia and 8.8% normothermia subjects, odds ratio (95% confidence interval) of 1.95 (0.56-7.79). Pneumonia occurred in 19% hypothermia versus 10.5% in normothermia subjects, odds ratio (95% confidence interval) of 1.99 (0.63-6.98).ConclusionsIntravascular therapeutic hypothermia was confirmed to be safe and feasible in recombinant tissue-type plasminogen activator-treated acute ischemic stroke patients. Protocol changes designed to reduce pneumonia risk appeared to fail, although the sample is small.Clinical trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01123161.
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- 2016
49. Systematic approach to consider HRC in early design phase
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Koch, Thomas, Beck, Joshua, and Mayer, Stephan
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- 2021
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50. Acute Blood Pressure and Outcome After Intracerebral Hemorrhage: The VISTA-ICH Cohort
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Francoeur, Charles L and Mayer, Stephan A
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- 2021
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