Search

Your search keyword '"Mayara Torquato Lima da Silva"' showing total 4 results
Start Over Author "Mayara Torquato Lima da Silva"
4 results on '"Mayara Torquato Lima da Silva"'

1. Genomic Variability of Hepatitis B Virus Circulating in Brazilian Western Amazon

Author

Tárcio Peixoto Roca, Livia Melo Villar, Felipe Souza Nogueira Lima, Mariana Pinheiro Alves Vasconcelos, Lourdes Maria Pinheiro Borzacov, Eugênia de Castro e Silva, Bárbara Vieira do Lago, Mayara Torquato Lima da Silva, Luan Felipo Botelho Souza, Juan Miguel Villalobos Salcedo, Alcione de Oliveira dos Santos, and Deusilene Souza Vieira

Subjects
mutation, genotype, clinical characterization, Microbiology, QR1-502
Abstract

The emergence of clinically relevant mutations in the hepatitis B virus (HBV) genome has been a matter of great debate because of the possibility of escape from the host’s immune system, the potential to cause more severe progression of liver diseases and the emergence of treatment-resistant variants. Here we characterized the circulating variants of HBV in Rondônia State, in the north of Brazil. Serum samples of 62 chronic HBV carriers were subjected to PCR assays and clinical data were collected. Mutations and genotypes were characterized through direct sequencing. The findings show the presence of subgenotypes A1 (54.83%, 34/62), D3 (16.13%, 10/62), F2 (16.13%, 10/62), A2 (4.84%, 3/62), D2 (3.23%, 2/62), D1 (1.61%, 1/62), D4 (1.61%, 1/62) and F4 (1.61%, 1/62). Deletions in the pre-S2 region were found in 13.79% (8/58) of the samples, mutations in the S gene in 59.68% (37/62) and RT mutations in 48.39% (30/62). We found a variable genotypic distribution in different locations and important mutations related to immune escape and drug resistance in Western Amazonia, which contributed to genetic surveillance and provided important information to help control the disease.

Published
2022
Full Text
View/download PDF

2. Exploring the potential usefulness of IgY for antiviral therapy: A current review

Author

Mayara Torquato Lima da Silva, Livia Melo Villar, and Raissa Martins Deodato

Subjects
biology, medicine.medical_treatment, Immunoglobulins, General Medicine, Disease, Immunotherapy, Antiviral Agents, Biochemistry, Virology, Immune system, Immunization, Antigen, Virus Diseases, Structural Biology, Viruses, Pandemic, medicine, biology.protein, Animals, Humans, Immunoglobulin Y, Antibody, Molecular Biology
Abstract

Immunoglobulin yolk (IgY) is therapeutic antibodies presented in yolk eggs of birds, reptiles, and amphibians. These proteins produced by the immune system of the animal, are capable of neutralizing antigenic molecules, including viral antigens, fulfilling a role in the body defense. The specificity of these antibodies and the facility for their production, make these molecules capable of being used as tools for diagnosis and immunotherapy. Regarding this last aspect, it is common knowledge that the field of virology, is racing against time in the development of new drugs and vaccines to try to contain pandemics and local epidemics and, in counterproposal, avian antibodies are neutralizing molecules that can help in the control and spread of disease. These molecules have been explored for years and currently chicken eggs are produced in large quantities from the animal's immunization against a specific pathogen. Thus, on this subject, this review made a survey of these researches and presents a summary of all the successful cases and perspectives in the use of IgYs as tools for viral immunization.

Published
2021

4. Antinociceptive effect of Lonchocarpus araripensis lectin: activation of L-arginine/NO/cGMP/K

Author

Ana Maria S, Assreuy, Renata Morais Ferreira, Amorim, Stephanie Lian, Martins, Maria Gleiciane, de Queiroz Martins, João Batista, Cajazeiras, Mayara Torquato Lima, da Silva, Alana Freitas, Pires, Kyria Santiago, Nascimento, Benildo Sousa, Cavada, and Mário Rogério Lima, Mota

Subjects
Male, Analgesics, Gene Expression, Fabaceae, Nitric Oxide Synthase Type I, Arginine, Carrageenan, Nitric Oxide, Mice, Adenosine Triphosphate, KATP Channels, Ganglia, Spinal, Lectins, Animals, Cyclic GMP, Signal Transduction
Abstract

The involvement of nitric oxide pathway in the antinociceptive activity of Lonchocarpus araripensis lectin (LAL) was investigated in the model of carragenan-induced hypernociception.Swiss mice received LAL (0.01-10 mg/kg; i.v.) 30 min before s.c. injection of carragenan in the paws. For the involvement of nociceptive pathways, animals were previously treated with the blockers: NOS (L-NAME, aminoguanidine, 7-nitroindazole); soluble guanylyl cyclase (ODQ); channels of ATP-dependent KLAL at all doses inhibited carrageenan-induced hypernociception (4.12 ± 0.58 g), being maximal at 10 mg/kg (3 h: 59%), and reversed by GlcNAc. At this time, LAL effect was reversed by nifedipine (39%), niflumic acid (59%), L-NAME (59%), 7-nitroindazole (44%), ODQ (45%), and glibenclamide (34%), but was unaltered by aminoguanidine. LAL increased (95%) nNOS gene expression in mice paw tissues, but not its immunoexpression in the dorsal root ganglia.The antinociceptive effect of Lonchocarpus araripensis lectin involves activation of the L-arginine/NO/GMPc/K

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results