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2. Abstracts of papers and posters

Author

Anthonio, R. L., Willemsen, A. T. M., Visser, T., van Waarde, A., Elzinga, P., Weemaes, A., Meeder, J. G., Pruim, J., Visser, G., Blanksma, P. K., Vaalburg, W., Bloemen, P. G. M., Henricks, P. A. J., van Bloois, L., van den Tweel, M. C., Nijkamp, F. P., Crommelin, D. J. A., Storm, G., de Boer, A. H., Winter, H. M. I., Lerk, C. F., de Boer, J., Meurs, H., Bottone, A. E., Koopal, M., Visser, J. C., Zaagsma, J., Borger P., Kauffman H. F., Vijgen J. L. J., Postma D. S., Vellenga E., Buckley, Theresa L., Buikema, H., van Gilst, W. H., van Veldhuisen, D. J., de Smet, B. J. G. L., Scholtens, E., Lie, K. I., Wesseling, H., Cheung, P. K., Dijkhuis, F. W. D., Bakker, W. W., Visser, J., Coopes, R. P., Benthem, L., van der Leest, J., Roffel, A. F., Coppes, R. P., Zeilstra, L. J. W., Vissink, A., Konings, A. W. T., Dijkstra, M., Veld, G. In't, Müller, M., van den Berg, G. J., Kuipers, F., Vonk, R. J., Elsinga, P. H., Franssen, E. J. F., van der Graaf, W. T. A., de Vries, E. G. E., Visser, G. M., Vos, M. G., Braker, A. H., Visser, T. J., Visser, G. M., Engels, F., van Houwelingen, A. H., van de Velde, M. J., Gansevoort, R. T., Sluiter, W. J., Hemmelder, M. H., de Zeeuw, D., de Jong, P. E., Gelissen, H. P. M. M., Henning, R. H., Epema, A. H., van Eekeren, J., Hennis, P. J., Den Hertog, A., de Graaf, S. S. N., Kellie, S. J., Bloemhof, H., Johnston, I., Besser, M., Chaseling, R. W., Ouvrier, R. A., Uqes, D. R. A., De Haan, A., Geerligs, H. J., Huchshorn, J. P., Van Scharenburg, G. J. M., Wilschut, J., Haas, M., Kluppel, C. A., Meijer, D. K. F., Moolenaar, F., Heerdink, Eibert R., Leufkens, Hubert G., Herings, Ron M. C., Stricker, Bruno H. Ch., Bakker, Albert, Heesen W. F., Beltman F. W., Smit A. J., May J. F., Meyboom-de Jong B., Duin, M., van den Akker, J., te Pas, M. F. W., van Popta, J. P., Nelemans, S. A., van der Linde, H. J., de Boer, A., Sturmans, F., Hessel, E. M., Van Oosterhout, A. J. M., Hofstra, C. L., Garssen, J., van Loveren, H., Savelkoul, H. F. J., Hoekstra, Y., Weersink, E. J. M., de Jong, J. W., van der Belt-Gritter, B., Jonkman, Lisa M., Kemner, Chantal, Koelega, Harry S., van Engeland, Herman, Verbaten, Marinus N., Kalivianakis, M., Zijlstra, I., Verkade, H. J., Elzinga, H., Stellaard, F., Kamps, J. A. A. M., Swart, P. J., Morselt, H., Scherphof, G. L., Kenemans, J. L., Lorist, M. M., Koopen, N. R., Kraneveld, A. D., Koster, A. Si., Kuipers, M. E., Groenink, M., Huisman, H., Schuitemaker, H., Lau, H. S., van den Broek, I. J. P. M., van Dijk, A., Oostinga, J., Porsius, A. J., Lin, Y., Havinga, R., Meijer, R. J., van der Mark, Th. W., Koëter, G. H., Michels, A. A., Nguyen, V. -T., Bensaude, O., Kampinga, H. H., Mohede, Inge C. M., Van Antoon J. M., Molema, Grietje, Edgington, Thomas S., Thorpe, Philip E., Olinga, P., Sandker, G. W., Slooff, M. J. H., Merema, M. T., Groothuis, G. M. M., Hofman, G., Van Ark, I., Paulussen, J. J. C., Fischer, M. J. E., de Mol, N. J., Janssen, L. H. M., Peters, E. Th. J., van der Werf, G. Th., Haaijer-Ruskamp, F. M., Pinto, Yigal M., Rooks, Gerrit, Grandjean, Jean G., Ebels, Tjark, Schunkert, H., Redegeld, Frank A., Garssen, Johan, van Loveren, Henk, Rigter, Irma M., van Groningen, Muck, Boks, Gertjan J., Tollenaere, Jan P., Trollope, Keith I., Vinter, Jeremy G., Hashjin, Gudarz Sadeghi, Folkerts, Gert, van de Loo, Peet G. F., Santing, R. E., Olymulder, C. G., van der Molen, K., Pasman, Y., Scheerens, Heleen, Van Loveren, Henk, Seppenwoolde-Waasdorp, T. J. A., de Boer, P., Van Engelen, H. M. J., Thijssen, J. H. H., Maes, R. A. A., Smit, J., Smit, J. W., Steen, H., Steurs, M. H., Kuks, P. F. M., Leusink, J. A., Szabó, Balázs M., Crijns, Harry J. G. M., Wiesfeld, Ans C. P., Talsma, H., Borchert, J. C. H., van Steenbergen, M. J., Hennink, W. E., Teeuw, K. B., Cromheecke, H., Schreudering, A., Teisman, B. C. H., Maselbas, W., Wolters-Keulemans, G. T. P., Tieleman, R. G., de Langen, C. D. J., Bel, K., Crijns, H. J. G. M., Grandjean, J., Wijffels, M., Klimp, A. H., van de Meer, P. F., Allessie, M. A., van Patot, H. A. Tissot, de Jongh, B. M., Tuininga, Y. S., Brouwer, J., Haaksma, J., Man in't Veld, A. J., Blomjous, F. J., Vingerhoeds, M. H., Belliot, S. O., Haisma, H. J., Visscher, C. A., Huisman, R. M., Navis, G. J., de Vlieger, J. F., van den Wijngaard, P., Wilting, J., van Heuven-Nolsen, D., Voors, A. A., van Brussel, B. L., Plokker, H. W. M., Van Waardenburg R. C. A. M., Meijer, Prins J., De Vries, C., Mulder N. H., Wierenga, P. K., Wilschut J., Schoen P., and Bron R.

Published
1994
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13. Abstracts of papers

Author

Wesseling, H., Veur, E. v. d., Berge, B. S. ten, Donker, A. J. M., May, J. F., Schuurman, F. H., van Schaik, B. A. M., Geyskes, G. G., Petri, H., Böhm, R., Mooy, J., van Kemenade, J., van Baak, M., Rahn, K. H., van Heereveld, H. A. E. M., Wollersheim, H., Thien, Th., Lammers, J. W. J., Folgering, H. Th. M., van Herwaarden, C. L. A., Graafsma, S. J., Snijders, P. J. F., de Miranda, J. F. Rodrigues, de Bruijn, E. A., van Oosterom, A. T., Kuppen, P. J. K., Jol, C., Tjaden, U. R., Trimbos, J. B., Runhaar, E. A., Nooij, H. A., van de Loo, A. A. J., Speth, P. A. J., Linssen, P. C. M., Haanen, C., Leeuwenkamp, O. R., Neyt, J. H., van der Vijgh, W. J. F., Pinedo, H. M., Schellens, J. H. M., Danhof, M., Breimer, D. D., Overdiek, J. W. P. M., Merkus, F. W. H. M., Teeuwen, H. W. A., de Schepper, P., Tjandramaga, T. B., van Rossum, J. M., Tukker, J. J., Blankenstein, M. A., Nortier, J. W. R., Zantvoort, F. A., Wagonvoort, J. H. T., Derkx, F. H. M., Michel, M. F., Wijnands, W. J. A., Baars, A. M., Vree, T. B., van Dalen, R., Termond, E. S. F., Boekema, P., Smits, P., de Abreu, R., Thlen, Th., van 't Laar, A., Böhm, R. O. B., Arends, B. G., van Hooff, H. E. J., van Baak, M. A., Derkx F., Tan-Tjiong H., Wenting G., Manin't Veld A., Schalekamp M., van Harten, J., van Brummelen, P., Danhof, H., Lodewijks, M. Th. M., Jansen, P. A. F., van Ginneken, C. A. M., Gribnau, F. W. J., Lohman, J. J. H. M., Hooymans, P. M., Merkus, F. W. H. H., Mol, M. J. T. M., Stalenhoef, A. F. H., Demacker, P. N. M., van't Laar, A., Raaijmakers, J. A. M., Terpstra, G. K., and Holdrinet, R. S. G.

Published
1986
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16. Acceptance and side effects of ambulatory blood pressure monitoring: Evaluation of a new technology

Author

Beltman, F W, Heesen, W F, Smit, A J, May, J F, Lie, K I, and Meyboom-de Jong, B

Subjects
side effects, ambulatory blood pressure monitoring, HYPERTENSION, SELF-MEASUREMENT, MANAGEMENT, SLEEP, acceptance
Abstract

Ambulatory blood pressure (BP) monitoring is probably becoming a clinically useful procedure for the evaluation of hypertensive patients. Previous reports have shown that the devices are safe and serious side effects are rare. Discomfort and inconveniences associated with its use are more frequent. In this study, patient acceptance of ambulatory blood pressure monitoring (ABPM) was compared with acceptance of other diagnostic procedures and their side effects were assessed. Patients were asked to fill in a form and 129 of 166 patients responded, The acceptance was measured with a visual analogue scale which ranged from 'very annoying' on the left to 'not annoying at all' on the right. All forms were collected anonymously. Mean distance (cm) of the visual likert scale was 8.6 to 9.4 for the diagnostic procedures frequently used in routine patient care. Ambulatory BP measurement (ABPM) scored 6.1 cm, Reported side effects (in 27% of patients) were: pain (9%), skin irritation (8%), noisy device (8%), inconvenience with work (3%), haematoma (2%) and other (4%). Reports from the patients on sleep quality were: 23% normal, 61% minor disturbance, 14% bad sleep, and 2% did not sleep at all, It can be concluded that ambulatory BP monitoring was the diagnostic procedure with the lowest patient acceptance. Side effects of this new technology were reported by 27% of patients. However, risks are relatively minor, Sleep disturbances were very frequent and was a serious problem for 16% of patients.

Published
1996

17. Predictive value of ambulatory blood pressure shortly after withdrawal of antihypertensive drugs in primary care patients

Author

Beltman, F. W., Heesen, W. F., Kok, R. H., Smit, A. J., May, J. F., de Graeff, P. A., Havinga, T. K., Schuurman, F. H., van der Veur, E., Lie, K. I., and Meyboom-de Jong, B.

Subjects
Research Article
Abstract

OBJECTIVE: To determine whether ambulatory blood pressure eight weeks after withdrawal of antihypertensive medication is a more sensitive measure than seated blood pressure to predict blood pressure in the long term. DESIGN: Patients with previously untreated diastolic hypertension were treated with antihypertensive drugs for one year; these were withdrawn in patients with well controlled blood pressure, who were then followed for one year. SETTING: Primary care. SUBJECTS: 29 patients fulfilling the criteria for withdrawal of antihypertensive drugs. MAIN OUTCOME MEASURES: Sensitivity, specificity, and positive and negative predictive value of seated and ambulatory blood pressure eight weeks after withdrawal of antihypertensive drugs. RESULTS: Eight weeks after withdrawal of medication, mean diastolic blood pressure returned to the pretreatment level on ambulatory measurements but not on seated measurements. One year after withdrawal of medication, mean diastolic blood pressure had returned to the pretreatment level both for seated and ambulatory blood pressure. For ambulatory blood pressure, the sensitivity and the positive predictive value eight weeks after withdrawal of medication were superior to those for seated blood pressure; specificity and negative predictive value were comparable for both types of measurement. Receiver operating characteristic curves showed that the results were not dependent on the cut off values that were used. CONCLUSION: Ambulatory blood pressure eight weeks after withdrawal of antihypertensive drugs predicts long term blood pressure better than measurements made when the patient is seated.

Published
1996

18. Groningen Hypertension Service: Ten Years Experience in Detecting and Treating Hypertension in a Population of 23,340 Persons in Rural and Urban Districts in Holland With a Special Hypertension Service

Author

Ten Berge, B. S., Havinga, T., May, J. F., Schuurman, F. H., Van der Veur, E., and Wesseling, H.

Abstract

The Groningen Hypertension Service (GHS) has demonstrated that provision of training for volunteers, technical assistance and the services of the General Practitioner Laboratory (a private foundation offering laboratory and diagnostic facilities) have enabled large rural and urban districts to be screened for hypertension within a short period of time at low cost. The GHS trained volunteers and paramedics, who assisted with the treatment for six months. The General Practitioner Laboratory evaluated treatment in nearly 600 hypertensive patients, leading to the institution of low-dose therapy and careful investigation of side-effects.

Published
1990

27. Increased a-linolenic acid intake lowers C-reactive protein, but has no effect on markers of atherosclerosis.

Author

Bemelmansh, W. J. E., Lefrandt, J. D., M. Feskens, E. J., Van Haelst, P. L., Broer, J., Meyboom-de Jong, B., May, J. F., Cohen Tervaert, J. W., and Smit, A. J.

Subjects
LINOLENIC acids, ATHEROSCLEROSIS, C-reactive protein, LIPOPROTEINS, CELL adhesion molecules, CARDIOVASCULAR diseases, DISEASE risk factors, INTERLEUKINS
Abstract

OBJECTIVE:: To investigate the effects of increased alpha-linolenic acid (ALA)-intake on intima-media thickness (IMT), oxidized low-density lipoprotein (LDL) antibodies, soluble intercellular adhesion molecule-1 (sICAM-1), C-reactive protein (CRP), and interleukins 6 and 10. DESIGN:: Randomized double-blind placebo-controlled trial. SUBJECTS:: Moderately hypercholesterolaemic men and women (55±10?y) with two other cardiovascular risk factors (n=103). INTERVENTION:: Participants were assigned to a margarine enriched with ALA (fatty acid composition 46% LA, 15% ALA) or linoleic acid (LA) (58% LA, 0.3% ALA) for 2?y. RESULTS:: Dietary ALA intake was 2.3?en% among ALA users, and 0.4?en% among LA users. The 2-y progression rate of the mean carotid IMT (ALA and LA: +0.05?mm) and femoral IMT (ALA:+0.05?mm; LA:+0.04?mm) was similar, when adjusted for confounding variables. After 1 and 2?y, ALA users had a lower CRP level than LA users (net differences -0.53 and -0.56?mg/l, respectively, P<0.05). No significant effects were observed in oxidized LDL antibodies, and levels of sICAM-1, interleukins 6 and 10. CONCLUSIONS:: A six-fold increased ALA intake lowers CRP, when compared to a control diet high in LA. The present study found no effects on markers for atherosclerosis. SPONSORSHIP:: The Dutch ‘Praeventiefonds’.European Journal of Clinical Nutrition (2004) 58, 1083-1089. doi:10.1038/sj.ejcn.1601938 [ABSTRACT FROM AUTHOR]

Published
2004
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32. Viscoelastic Properties of 1-Hexene—Propene Copolymers Influence of the Structure and Morphology on the ß Relaxation

Author

Piloz, A, Douillard, A, Decroix, J Y, May, J F, and Vallet, G

Abstract

The dynamic mechanical properties of 1-hexene—propene copolymers were measured in the ß-relaxation range, using a DDV-II Rheovibron viscoelastici-meter. The infrared spectroscopy showed typical bands, from which the copolymer composition could be evaluated and the crystallization ability deduced. The study of the morphology was performed by differential thermal analysis and X-ray diffraction. It led to a model of the copolymers’ crystalline structure in which there is still a crystalline fraction up to 60-% 1-hexene concentration (in moles). The experimental results showed that the maximum of tand shifted towards low temperatures as the 1-hexene concentration increased. Its magnitude grows as the crystallinity decreases. The activation energies associated with relaxation were calculated according to the Arrhenius equation; the average relaxation times were calculated by application of the time—temperature correspondence principle.

Published
1974
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33. A comparison of labetalol and prazosin combined with atenolol in non-responders to atenolol plus hydrochlorothiazide in uncomplicated hypertension

Author

Veur, E., Berge, B. S., Donker, A. J. M., May, J. F., Schuurman, F. H., and Wesseling, H.

Abstract

After screening two local populations in the northern part of The Netherlands for hypertension, patients with a diastolic pressure (DP) between 95 and 120 mmHg were treated daily either with 50 mg hydrochlorothiazide or 100 mg atenolol. Non-responders were given the combination and if necessary the dose of atenolol was increased to 200 mg. Non-responders to the latter combination were randomized and treated either with 50 mg hydrochlorothiazide and labetalol or with 50 mg hydrochlorothiazide, 200 mg atenolol and prazosin. If after 1 month a DP=90 mmHg had been reached the patient was reassessed after a further 3 months. If a DP>90 mmHg was found the dose of labetalol or prazosin was increased and the patient was re-examined after 1 month.

Published
1985
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34. Comparison of labetalol, propranolol and hydralazine in hypertensive out-patients

Author

Veur, E., Berge, B. S., Donker, A. J. M., May, J. F., and Wesseling, H.

Abstract

In a randomised cross-over trial the combination labetalol/hydrochlorothiazide was compared with the combination of propranolol/hydralazine/hydrochlorothiazide in 34 uncomplicated hypertensive patients, who were not satisfactorily controlled with hydrochlorothiazide 50 mg alone. The elevated diastolic pressure (D.P.) in 27 patients responded satisfactorily to the labetalol schedule and in 28 patients to the propranolol/hydralazine schedule. No difference was found in the rate of decrease of D.P., nor in the disappearance of hypertension — related complaints. Although the duration of the washout between treatments was at least one month, treatment was significantly more efficacious during the second period. Labetalol pre-treatment especially seemed to enhance the effect of subsequent propranolol/hydralazine administration. Side effects due to therapy were rare and were not related to any particular treatment. The median daily dose of labetalol in responders was 600 mg and that of propranolol/hydralazine 120/60 mg (in both therapies hydrochlorothiazide 50 mg was given in addition). Patients showed a slight preference for the labetaol medication. It is concluded that labetalol/hydrochlorothiazide and propranolol/hydralazine/hydrochlorothiazide are equally satisfactory in the treatment of uncomplicated hypertension.

Published
1982
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35. Comparison of hydrochlorothiazide and atenolol as initial treatment in uncomplicated hypertension

Author

Veur, E., Berge, B. S., Donker, A. J. M., May, J. F., Schuurman, F. H., and Wesseling, H.

Abstract

After screening a local population in the northern part of The Netherlands for hypertension, 119 patients with a diastolic pressure (DP) between 95 and 120 mmHg were randomised and treated either with 50 mg hydrochlorothiazide (n=59) or 100 mg atenolol (n=60). After 1 month of treatment 6 patients in the hydrochlorothiazide group and 24 patients in the atenolol group had reached a DP?90 mmHg (p<0.001). 43 of the 50 non-responders to hydrochlorothiazide were switched to atenolol and 30 of the 35 non-responders to atenolol were changed to hydrochlorothiazide. One month after the switch 19 patients in the atenolol group and 2 patients in the hydrochlorothiazide group had reached a DP?90 mmHg (p<0.001). After 6 months of treatment 32 of the 43 atenolol responders and 7 of the 8 hydrochlorothiazide responders were still receiving the same medication, as their DP was still?90 mmHg. Non-responders to either medication were given the combination (n=46). 21 patients now became normotensive as did a further 10 after increasing the dose of atenolol to 200 mg. Thus, in all 70 patients had a blood pressure ?90 mmHg after treatment for 4 months. Both drugs induced a significant reduction in the total of number of complaints after 1 month of treatment. They did not differ from each other. The reduction was seen both in responders and non-responders and persisted during treatment for 6 months. It is concluded that in terms of short-term efficacy the cardioselective, hydrophilic beta adrenoceptor-blocking drug atenolol is preferable to hydrochlorothiazide in the treatment of uncomplicated hypertension.

Published
1984
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50. Comparison of atenolol 50 mg and 100 mg as initial treatment in uncomplicated mild to moderate hypertension

Author

Veur, E., Berge, B. S., Donker, A. J. M., May, J. F., Schuurman, F. H., and Wesseling, H.

Abstract

After screening a local population in the northern part of The Netherlands for hypertension, 59 patients with a diastolic pressure (DP) between 95 and 130 mmHg were randomized and treated either with 50 mg atenolol (n=29) or 100 mg atenolol (n=30) for 1 month. There was no significant difference between the two treatments, neither in the fall in systolic and diastolic pressures nor in the number of complaints reported. It is concluded that in the initial treatment of uncomplicated mild to moderate hypertension, 100 mg atenolol has no advantage over a 50 mg dose.

Published
1985
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