2,104 results on '"Maxwell V"'
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2. Taxonomic notes on the collection of the tribe Lamiini (Coleoptera, Cerambycidae) housed in the Natural History Museum, London
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Guanglin Xie, Maxwell V. L. Barclay, and Wenkai Wang
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Zoology ,QL1-991 - Abstract
In the present paper, the genus Mimomyagrus Breuning, 1970 is synonymized with Combe Thomson, 1864, and Mimomyagrus pfanneri Breuning, 1970 is considered a junior synonym of Combe brianus (White, 1858). The female of Arctolamia sinica Bi & Chen, 2022 is described for the first time and this species is reported as new to Myanmar. Type material of Lamia punctator Fabricius, 1776 [= Anoplophora chinensis (Forster, 1771)], Cerambyx galloprovincialis Olivier, 1800 [= Monochamus galloprovincialis (Olivier, 1800)] and Melanauster granulipennis Breuning, 1938 [= Monochamus guerryi Pic, 1903] are confirmed to be preserved in Natural History Museum, London.
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- 2024
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3. The genome sequence of the willow leaf beetle, Lochmaea capreae Linnaeus, 1758 [version 2; peer review: 2 approved]
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Maxwell V. L. Barclay, Keita Matsumoto, Danaë Vassiliades, Will Bayfield-Farrell, Joana Cristóvão, and Michael Geiser
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Lochmaea capreae ,willow leaf beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual female Lochmaea capreae (the willow leaf beetle; Arthropoda; Insecta; Coleoptera; Chrysomelidae). The genome sequence is 534.7 megabases in span. Most of the assembly is scaffolded into 17 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 18.85 kilobases in length. Gene annotation of this assembly on Ensembl identified 12,254 protein coding genes.
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- 2024
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4. The genome sequence of the oak pinhole borer, Platypus cylindrus (Fabricius, 1792) [version 2; peer review: 2 approved, 1 approved with reservations]
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Mark G. Telfer, Maxwell V. L. Barclay, Keita Matsumoto, Danaë Vassiliades, Joana Cristóvão, Michael Geiser, and Will Bayfield Farrell
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Platypus cylindrus ,oak pinhole borer ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual male Platypus cylindrus (the oak pinhole borer; Arthropoda; Insecta; Coleoptera; Curculionidae). The genome sequence is 147.5 megabases in span. Most of the assembly is scaffolded into 8 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled and is 19.29 kilobases in length. Gene annotation of this assembly on Ensembl identified 13,468 protein coding genes.
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- 2024
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5. The genome sequence of a soldier beetle, Cantharis flavilabris Fallén, 1807 [version 2; peer review: 2 approved, 1 not approved]
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Maxwell V. L. Barclay
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Cantharis flavilabris ,soldier beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual female Cantharis flavilabris (soldier beetle; Arthropoda; Insecta; Coleoptera; Cantharidae). The genome sequence is 348.3 megabases in span. Most of the assembly is scaffolded into 7 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 17.5 kilobases in length. Gene annotation of this assembly on Ensembl identified 22,711 protein coding genes.
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- 2024
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6. The genome sequence of the Dogs-Mercury Flea Beetle, Hermaeophaga mercurialis (Fabricius, 1792) [version 1; peer review: 2 approved]
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Dominic Phillips, Maxwell V. L. Barclay, Mark Telfer, and Liam M. Crowley
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Hermaeophaga mercurialis ,Dogs-Mercury Flea Beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual Dogs-Mercury Flea Beetle, Hermaeophaga mercurialis (Arthropoda; Insecta; Coleoptera; Chrysomelidae). The genome sequence has a length of 479.40 megabases. Most of the assembly is scaffolded into 9 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 16.05 kilobases in length. Gene annotation of this assembly on Ensembl identified 12,633 protein-coding genes.
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- 2024
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7. The genome sequence of a ground beetle, Clivina fossor (Linnaeus, 1758) [version 1; peer review: 2 approved]
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Maxwell V. L. Barclay, Xavier Richard Badham, Mark Telfer, and Liam M. Crowley
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Clivina fossor ,a ground beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual female Clivina fossor (a ground beetle; Arthropoda; Insecta; Coleoptera; Carabidae). The genome sequence spans 612.60 megabases. Most of the assembly is scaffolded into 22 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 16.48 kilobases in length.
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- 2024
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8. The genome sequence of a braconid wasp, Dinocampus coccinellae (Schrank, 1802) [version 1; peer review: 2 approved, 1 approved with reservations]
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Gavin R. Broad and Maxwell V. L. Barclay
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Dinocampus coccinellae ,a braconid wasp ,genome sequence ,chromosomal ,Hymenoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual female Dinocampus coccinellae (a braconid wasp; Arthropoda; Insecta; Hymenoptera; Braconidae). The genome sequence spans 110.40 megabases. Most of the assembly is scaffolded into 8 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 22.88 kilobases in length.
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- 2024
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9. The genome sequence of the oak pinhole borer, Platypus cylindrus Fabricius, 1792 [version 1; peer review: 2 approved, 1 approved with reservations]
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Mark G. Telfer, Maxwell V. L. Barclay, Keita Matsumoto, Danaë Vassiliades, Joana Cristóvão, Michael Geiser, and Will Bayfield Farrell
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Platypus cylindrus ,oak pinhole borer ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual male Platypus cylindrus (the oak pinhole borer; Arthropoda; Insecta; Coleoptera; Curculionidae). The genome sequence is 147.5 megabases in span. Most of the assembly is scaffolded into 8 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled and is 19.29 kilobases in length. Gene annotation of this assembly on Ensembl identified 13,468 protein coding genes.
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- 2024
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10. The genome sequence of a soldier beetle, Cantharis flavilabris Fallén, 1807 [version 1; peer review: 2 approved, 1 not approved]
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Maxwell V. L. Barclay
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Cantharis flavilabris ,soldier beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual female Cantharis flavilabris (soldier beetle; Arthropoda; Insecta; Coleoptera; Cantharidae). The genome sequence is 348.3 megabases in span. Most of the assembly is scaffolded into 7 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 17.5 kilobases in length. Gene annotation of this assembly on Ensembl identified 22,711 protein coding genes.
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- 2024
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11. The genome sequence of a false flower beetle, Anaspis maculata (Geoffroy in Fourcroy, 1785) [version 1; peer review: 2 approved, 1 approved with reservations]
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Mark G. Telfer, Dominic Phillips, and Maxwell V. L. Barclay
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Anaspis maculata ,false flower beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual female Anaspis maculata (false flower beetle; Arthropoda; Insecta; Coleoptera; Scraptiidae). The genome sequence is 757.8 megabases in span. Most of the assembly is scaffolded into 8 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 16.31 kilobases in length. Gene annotation of this assembly on Ensembl identified 21,965 protein coding genes.
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- 2024
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12. Association of household net worth with healthcare costs after radical cystectomy using real‐world data
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Samuel L. Washington III, Peter E. Lonergan, Anobel Y. Odisho, Maxwell V. Meng, and Sima P. Porten
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bladder cancer care ,healthcare utilization ,household net worth ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Financial toxicity of bladder cancer care may influence how patients utilize healthcare resources, from emergency department (ED) encounters to office visits. We aim to examine whether greater household net worth (HHNW) confers differential access to healthcare resources after radical cystectomy (RC). Methods This population‐based cohort study examined the association between HHNW and healthcare utilization costs in the 90 days post‐RC in commercially insured patients with bladder cancer. Costs accrued from the index hospitalization to 90 days after including health plan costs (HPC) and out‐of‐pocket costs (OPC). Multivariable logistic regression models were generated by encounter (acute inpatient, ED, outpatient, and office visit). Results A total of 141,903 patients were identified with HHNW categories near evenly distributed. Acute inpatient encounters incurred the greatest HPC and OPC. Office visits conferred the lowest HPC while ED visits had the lowest OPC. Black patients harbored increased odds of an acute inpatient encounter (OR 1.22, 95% CI 1.16–1.29) and ED encounter (OR 1.20, 95% CI 1.14–1.27) while Asian (OR 0.76, 95% CI 0.69–0.85) and Hispanic (OR 0.74, 95% CI 0.69–0.78, p
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- 2024
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13. The genome sequence of a click beetle, Melanotus villosus (Geoffroy in Fourcroy, 1785) [version 1; peer review: 2 approved]
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Maxwell V. L. Barclay, Duncan Sivell, and Howard Mendel
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Melanotus villosus ,click beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual female Melanotus villosus (click beetle; Arthropoda; Insecta; Coleoptera; Elateridae). The genome sequence is 803.5 megabases in span. Most of the assembly is scaffolded into 10 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 15.91 kilobases in length.
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- 2024
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14. The genome sequence of the Judas Tree Seed Beetle, Bruchidius siliquastri Delobel, 2007 [version 1; peer review: 2 approved]
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Maxwell V. L. Barclay, Keita Matsumoto, Michael Geiser, and Emily Pash
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Bruchidius siliquastri ,the Judas tree Seed Beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual male Bruchidius siliquastri (the Judas tree Seed Beetle; Arthropoda; Insecta; Coleoptera; Chrysomelidae). The genome sequence is 375.6 megabases in span. Most of the assembly is scaffolded into 11 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled and is 15.81 kilobases in length. Gene annotation of this assembly on Ensembl identified 17,940 protein coding genes.
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- 2024
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15. The collection of the genus Epepeotes Pascoe, 1866 housed in the Natural History Museum, London (Coleoptera, Cerambycidae)
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Guanglin Xie, Maxwell V. L. Barclay, and Wenkai Wang
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Zoology ,QL1-991 - Abstract
Data on the collection of the genus Epepeotes Pascoe, 1866 deposited in the Natural History Museum, London are presented. A total of 23 species/subspecies, including type specimens of 18 names, of them 13 valid, are recorded. Epepeotes uncinatus lineatopunctatus Breuning, 1960 is restored to subspecies-level status. Lectotypes are designated for Epepeotes uncinatus uncinatus Gahan, 1888 and Epepeotes andamanicus Gahan, 1893. Epepeotes luscus luscus (Fabricius, 1787) is newly recorded in Cambodia and Singapore, and Epepeotes uncinatus uncinatus Gahan, 1888 is newly recorded in Bangladesh. Images of the type and other significant specimens are provided for 23 taxa, mainly for the first time.
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- 2023
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16. Review of the genus Xenicotela Bates, 1884 (Cerambycidae, Lamiinae, Lamiini)
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Guanglin Xie, Maxwell V. L. Barclay, and Wenkai Wang
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Zoology ,QL1-991 - Abstract
The species of the genus Xenicotela Bates, 1884 are reviewed. One new species, Xenicotela mucheni sp. nov., is described from Yunnan, China. Monochamus binigricollis Breuning, 1965 and Monochamus villiersi Breuning, 1960 are transferred to Xenicotela as follows: Xenicotela villiersi (Breuning, 1960) comb. nov. and Xenicotela binigricollis (Breuning, 1965) comb. nov. Xenicotela distincta (Gahan, 1888) is newly reported from Myanmar and Xenicotela binigricollis is excluded from the fauna of China. All species are redescribed and illustrated. A key to the known Xenicotela species is provided.
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- 2023
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17. The genome sequence of a weevil, Polydrusus cervinus (Linnaeus, 1758) [version 1; peer review: 2 approved]
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Maxwell V. L. Barclay
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Polydrusus cervinus ,weevil ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual female Polydrusus cervinus (a weevil; Arthropoda; Insecta; Coleoptera; Curculionidae). The genome sequence is 713.4 megabases in span. Most of the assembly is scaffolded into 11 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 18.22 kilobases in length. Gene annotation of this assembly on Ensembl identified 23,058 protein coding genes.
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- 2023
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18. Diet, Physical Activity, and Smoking in Patients Living with Non-Muscle Invasive Bladder Cancer
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Elizabeth Y. Wang, Manuel Armas-Phan, Maxwell V. Meng, Sima P. Porten, and Stacey A. Kenfield
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modifiable behaviors ,bladder cancer ,epidemiology ,observational ,Medicine - Abstract
Background Modifiable lifestyle factors have been implicated in bladder cancer outcomes. Further study is warranted to inform future strategies in patients with non-muscle invasive bladder cancer (NMIBC). Objective We aim to describe modifiable behaviors (smoking, diet, and physical activity) in a cohort of patients with NMIBC. Methods We conducted an observational cross-sectional study in patients undergoing surveillance for NMIBC. A comprehensive survey comprised of validated measures of physical activity, diet, and mutagen consumption was administered. We assessed a “healthy lifestyle score” consisting of body mass index (BMI)
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- 2023
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19. The genome sequence of a ground beetle, Pterostichus niger (Schaller, 1783) [version 1; peer review: 2 approved]
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Maxwell V. L. Barclay, Danaë Vassiliades, Michael Geiser, Joana Cristóvão, and Will Bayfield Farrell
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Pterostichus niger ,ground beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual male Pterostichus niger (a ground beetle; Arthropoda; Insecta; Coleoptera; Carabidae). The genome sequence is 674.1 megabases in span. Most of the assembly is scaffolded into 19 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 17.16 kilobases in length.
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- 2023
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20. The genome sequence of a darkling beetle, Lagria hirta (Linnaeus, 1758) [version 1; peer review: 2 approved]
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Maxwell V. L. Barclay, Olga Sivell, and Brian Levey
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Lagria hirta ,darkling beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual male Lagria hirta (darkling beetle; Arthropoda; Insecta; Coleoptera; Tenebrionidae). The genome sequence is 336.8 megabases in span. Most of the assembly is scaffolded into 12 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled and is 16.12 kilobases in length. Gene annotation of this assembly on Ensembl identified 12,850protein coding genes.
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- 2023
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21. The genome sequence of a ground beetle, Leistus spinibarbis (Fabricius, 1775) [version 1; peer review: 2 approved]
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Maxwell V. L. Barclay
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Leistus spinibarbis ,a ground beetle ,genome sequence ,chromosomal ,Coleoptera ,eng ,Medicine ,Science - Abstract
We present a genome assembly from an individual male Leistus spinibarbis (a ground beetle; Arthropoda; Insecta; Coleoptera; Carabidae). The genome sequence is 235.1 megabases in span. Most of the assembly is scaffolded into 23 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 15.82 kilobases in length. Gene annotation of this assembly on Ensembl identified 23,576 protein coding genes.
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- 2023
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22. Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
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Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J. Madden, Cristine M. Charlesworth, Yuka A. Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C. Ikezu, Aishe Kurti, Yiyang Zhu, Axel Meneses, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Lucy K. Vanmaele, Fuyao Li, Kai Chen, Francis Shue, Maxwell V. Dacquel, John Fryer, Akhilesh Pandey, Na Zhao, and Guojun Bu
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Trem2 H157Y mutation ,Soluble TREM2 ,Microglia ,Synaptic plasticity ,Amyloid pathology ,Aβ clearance ,Neurology. Diseases of the nervous system ,RC346-429 ,Geriatrics ,RC952-954.6 - Abstract
Abstract Background The rare p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) was found to increase Alzheimer’s disease (AD) risk. This mutation is located at the cleavage site of TREM2 extracellular domain. Ectopic expression of TREM2-H157Y in HEK293 cells resulted in increased TREM2 shedding. However, the physiological outcomes of the TREM2 H157Y mutation remain unknown in the absence and presence of AD related pathologies. Methods We generated a novel Trem2 H157Y knock-in mouse model through CRISPR/Cas9 technology and investigated the effects of Trem2 H157Y on TREM2 proteolytic processing, synaptic function, and AD-related amyloid pathologies by conducting biochemical assays, targeted mass spectrometry analysis of TREM2, hippocampal electrophysiology, immunofluorescent staining, in vivo micro-dialysis, and cortical bulk RNA sequencing. Results Consistent with previous in vitro findings, Trem2 H157Y increases TREM2 shedding with elevated soluble TREM2 levels in the brain and serum. Moreover, Trem2 H157Y enhances synaptic plasticity without affecting microglial density and morphology, or TREM2 signaling. In the presence of amyloid pathology, Trem2 H157Y accelerates amyloid-β (Aβ) clearance and reduces amyloid burden, dystrophic neurites, and gliosis in two independent founder lines. Targeted mass spectrometry analysis of TREM2 revealed higher ratios of soluble to full-length TREM2-H157Y compared to wild-type TREM2, indicating that the H157Y mutation promotes TREM2 shedding in the presence of Aβ. TREM2 signaling was further found reduced in Trem2 H157Y homozygous mice. Transcriptomic profiling revealed that Trem2 H157Y downregulates neuroinflammation-related genes and an immune module correlated with the amyloid pathology. Conclusion Taken together, our findings suggest beneficial effects of the Trem2 H157Y mutation in synaptic function and in mitigating amyloid pathology. Considering the genetic association of TREM2 p.H157Y with AD risk, we speculate TREM2 H157Y in humans might increase AD risk through an amyloid-independent pathway, such as its effects on tauopathy and neurodegeneration which merit further investigation.
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- 2023
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23. Taxonomic study on the genus Xenicotela Bates from China (Cerambycidae, Lamiinae, Lamiini)
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Guanglin Xie, Maxwell V. L. Barclay, and Bin Chen
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Zoology ,QL1-991 - Abstract
A taxonomic review of the Chinese species of the genus Xenicotela Bates, 1884 is presented. A new species, Xenicotela griseomaculata sp. nov., is described from Chongqing, China, and a new combination, Xenicotela convexicollis (Gressitt, 1942) comb. nov., is proposed.
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- 2022
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24. A systematic review and meta-analysis on delaying surgery for urothelial carcinoma of bladder and upper tract urothelial carcinoma: Implications for the COVID19 pandemic and beyond
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Jeffrey J. Leow, Wei Shen Tan, Wei Phin Tan, Teck Wei Tan, Vinson Wai-Shun Chan, Kari A. O. Tikkinen, Ashish Kamat, Shomik Sengupta, Maxwell V. Meng, Shahrokh Shariat, Morgan Roupret, Karel Decaestecker, Nikhil Vasdev, Yew Lam Chong, Dmitry Enikeev, Gianluca Giannarini, Vincenzo Ficarra, Jeremy Yuen-Chun Teoh, and On behalf of the UroSoMe Collaborators
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delay in surgery ,delayed treatment ,time-to-treatment ,urinary bladder neoplasms ,ureteral neoplasms ,urothelial carcinoma ,Surgery ,RD1-811 - Abstract
PurposeThe COVID-19 pandemic has led to competing strains on hospital resources and healthcare personnel. Patients with newly diagnosed invasive urothelial carcinomas of bladder (UCB) upper tract (UTUC) may experience delays to definitive radical cystectomy (RC) or radical nephro-ureterectomy (RNU) respectively. We evaluate the impact of delaying definitive surgery on survival outcomes for invasive UCB and UTUC.MethodsWe searched for all studies investigating delayed urologic cancer surgery in Medline and Embase up to June 2020. A systematic review and meta-analysis was performed.ResultsWe identified a total of 30 studies with 32,591 patients. Across 13 studies (n = 12,201), a delay from diagnosis of bladder cancer/TURBT to RC was associated with poorer overall survival (HR 1.25, 95% CI: 1.09–1.45, p = 0.002). For patients who underwent neoadjuvant chemotherapy before RC, across the 5 studies (n = 4,316 patients), a delay between neoadjuvant chemotherapy and radical cystectomy was not found to be significantly associated with overall survival (pooled HR 1.37, 95% CI: 0.96–1.94, p = 0.08). For UTUC, 6 studies (n = 4,629) found that delay between diagnosis of UTUC to RNU was associated with poorer overall survival (pooled HR 1.55, 95% CI: 1.19–2.02, p = 0.001) and cancer-specific survival (pooled HR of 2.56, 95% CI: 1.50–4.37, p = 0.001). Limitations included between-study heterogeneity, particularly in the definitions of delay cut-off periods between diagnosis to surgery.ConclusionsA delay from diagnosis of UCB or UTUC to definitive RC or RNU was associated with poorer survival outcomes. This was not the case for patients who received neoadjuvant chemotherapy.
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- 2022
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25. Correction: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
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Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J. Madden, Cristine M. Charlesworth, Yuka A. Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C. Ikezu, Aishe Kurti, Yiyang Zhu, Axel Meneses, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Lucy K. Vanmaele, Fuyao Li, Kai Chen, Francis Shue, Maxwell V. Dacquel, John Fryer, Akhilesh Pandey, Na Zhao, and Guojun Bu
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Neurology. Diseases of the nervous system ,RC346-429 ,Geriatrics ,RC952-954.6 - Published
- 2023
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26. Race modifies survival benefit of guideline‐based treatment: Implications for reducing disparities in muscle invasive bladder cancer
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Samuel L. Washington III, Steven E. Gregorich, Maxwell V. Meng, Anne M. Suskind, and Sima P. Porten
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African continental ancestry group ,cohort studies ,social determinants of health ,United States ,urinary bladder neoplasms ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Black individuals with muscle‐invasive bladder cancer (MIBC) experienced 21% lower odds of guideline‐based treatment (GBT) and differences in treatment explain 35% of observed Black‐White differences in survival. Yet little is known of how interactions between race/ethnicity and receipt of GBT drive within‐ and between‐race survival differences. Methods Black, White, and Latino individuals diagnosed with nonmetastatic, locally advanced MIBC from 2004 to 2013 within the National Cancer Database were included. Guideline‐based treatment was defined as the receipt including one or more of the following treatment modalities: radical cystectomy (RC), neoadjuvant chemotherapy with RC, RC with adjuvant chemotherapy, and/or chemoradiation based on American Urological Association guidelines. Cox proportional hazards model of mortality estimated effects of GBT status, race/ethnicity, and the GBT‐by‐race/ethnicity interaction, adjusting for covariates. Results Of the 54 910 MIBC individuals with 125 821 person‐years of posttreatment observation (max = 11 years), 6.9% were Black, and 3.0% were Latino. Overall, 51.4%, 45.3%, and 48.5% of White, Black, and Latino individuals received GBT. Latino individuals had lower hazard of death compared to Black (HR 0.81, 95% CI 0.75‐0.87) and White individuals (HR 0.92, 95% 0.86‐0.98). With GBT, Latino and White individuals had similar outcomes (HR = 1.00, 95% 0.91‐1.10) and both fared better than Black individuals (HR = 0.88, 95% 0.79‐0.99 and HR = 0.88, 95% 0.83‐0.94, respectively). Without GBT, Latino individuals fared better than White (HR = 0.85, 95% 0.77‐0.93) and Black individuals (HR = 0.74, 95% 0.67‐0.82) while White individuals fared better than Black individuals (HR = 0.87, 95% 0.83‐0.92). Black individuals with GBT fared worse than Latinos without GBT (HR = 1.02, 95% 0.92‐1.14), although not statistically significant. Conclusion Low GBT levels demonstrated an “under‐allocation” of GBT to those who needed it most—Black individuals. Interventions to improve GBT allocation may mitigate race‐based survival differences observed in MIBC.
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- 2020
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27. Correction to: A comparison of stage-specific all-cause mortality between testicular sex cordstromal tumors and germ cell tumors: results from the National Cancer Database
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Kyle B. Zuniga, Samuel L. Washington, Sima P. Porten, and Maxwell V. Meng
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Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
An amendment to this paper has been published and can be accessed via the original article.
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- 2020
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28. A comparison of stage-specific all-cause mortality between testicular sex cord stromal tumors and germ cell tumors: results from the National Cancer Database
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Kyle B. Zuniga, Samuel L. Washington, Sima P. Porten, and Maxwell V. Meng
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Testicular neoplasms ,Leydig cell tumors ,Sertoli cell tumors ,Sex cord-gonadal stromal tumors ,Testicular germ cell tumors ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background Testicular sex cord stromal tumors (SCSTs) are managed similarly to germ cell tumors (GCTs); however, few studies have directly compared outcomes between these tumor types. Using the National Cancer Database (NCDB), we sought to compare overall and stage-specific all-cause mortality (ACM) between SCSTs versus GCTs. Methods NCDB was queried for patients diagnosed with SCSTs and GCTs between 2004 and 2013. Descriptive statistics were used to compare sociodemographic and clinical characteristics between groups. Univariable and multivariable Cox proportional hazards regression analyses were used to assess associations with ACM. Results We identified 42,192 patients diagnosed with testicular cancer between 2004 and 2013, with 280 having SCSTs and 41,912 patients having GCTs. Median age for SCSTs and GCTs was 45 (interquartile range [IQR] 34–59) and 34 (IQR 27–43), respectively (p
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- 2020
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29. Multidisciplinary investigation of two Egyptian child mummies curated at the University of Tartu Art Museum, Estonia (Late/Graeco-Roman Periods).
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Ester Oras, Jaanika Anderson, Mari Tõrv, Signe Vahur, Riina Rammo, Sünne Remmer, Maarja Mölder, Martin Malve, Lehti Saag, Ragnar Saage, Anu Teearu-Ojakäär, Pilleriin Peets, Kristiina Tambets, Mait Metspalu, David C Lees, Maxwell V L Barclay, Martin J R Hall, Salima Ikram, and Dario Piombino-Mascali
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Medicine ,Science - Abstract
Two ancient Egyptian child mummies at the University of Tartu Art Museum (Estonia) were, according to museum records, brought to Estonia by the young Baltic-German scholar Otto Friedrich von Richter, who had travelled in Egypt during the early 19th century. Although some studies of the mummies were conducted, a thorough investigation has never been made. Thus, an interdisciplinary team of experts studied the remains using the most recent analytical methods in order to provide an exhaustive analysis of the remains. The bodies were submitted for osteological and archaeothanatological study, radiological investigation, AMS radiocarbon dating, chemical and textile analyses, 3D modelling, entomological as well as aDNA investigation. Here we synthesize the results of one of the most extensive multidisciplinary analyses of ancient Egyptian child mummies, adding significantly to our knowledge of such examples of ancient funerary practices.
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- 2020
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30. Integrative analysis of the epigenetic basis of muscle-invasive urothelial carcinoma
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Thomas Sanford, Maxwell V. Meng, Reema Railkar, Piyush K. Agarwal, and Sima P. Porten
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Epigenetics ,Urothelial carcinoma ,Integrative analyses ,Medicine ,Genetics ,QH426-470 - Abstract
Abstract Background Elucidation of epigenetic alterations in bladder cancer will lead to further understanding of the biology of the disease and hopefully improved therapies. Our aim was to perform an integrative epigenetic analysis of invasive urothelial carcinoma of the bladder to identify the epigenetic abnormalities involved in the development and progression of this cancer. Methods Pre-processed methylation data and RNA-seq data were downloaded from The Cancer Genome Atlas (TCGA) and processed using the R package TCGA-Assembler. An R package MethylMix was used to perform an analysis incorporating both methylation and gene expression data on all samples, as well as a subset analysis comparing patients surviving less than 2 years and patients surviving more than 2 years. Genes associated with poor prognosis were individually queried. Pathway analysis was performed on statistically significant genes identified by MethylMix criteria using ConsensusPathDB. Validation was performed using flow cytometry on bladder cancer cell lines. Results A total of 408 patients met all inclusion criteria. There were a total of 240 genes differentially methylated by MethylMix criteria. Review of individual genes specific to poor-prognosis patients revealed the majority to be candidate tumor suppressors in other cancer types. Pathway analysis showed increase in methylation of genes involved in antioxidant pathways including glutathione and NRF2. Genes involved in estrogen metabolism were also hypermethylated while genes involved in the EGFR pathway were found to be hypomethylated. EGFR expression was confirmed to be elevated in six bladder cancer cell lines. Conclusions In patients with invasive urothelial carcinoma, we found differential methylation in patients with better and worse prognosis after cystectomy. Differentially methylated genes are involved in many relevant oncologic pathways, including EGFR and antioxidant pathways, that may be a target for therapy or chemoprevention.
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- 2018
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31. Thresholds for adding degraded tropical forest to the conservation estate
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Ewers, Robert M., Orme, C. David L., Pearse, William D., Zulkifli, Nursyamin, Yvon-Durocher, Genevieve, Yusah, Kalsum M., Yoh, Natalie, Yeo, Darren C. J., Wong, Anna, Williamson, Joseph, Wilkinson, Clare L., Wiederkehr, Fabienne, Webber, Bruce L., Wearn, Oliver R., Wai, Leona, Vollans, Maisie, Twining, Joshua P., Turner, Edgar C., Tobias, Joseph A., Thorley, Jack, Telford, Elizabeth M., Teh, Yit Arn, Tan, Heok Hui, Swinfield, Tom, Svátek, Martin, Struebig, Matthew, Stork, Nigel, Sleutel, Jani, Slade, Eleanor M., Sharp, Adam, Shabrani, Adi, Sethi, Sarab S., Seaman, Dave J. I., Sawang, Anati, Roxby, Gabrielle Briana, Rowcliffe, J. Marcus, Rossiter, Stephen J., Riutta, Terhi, Rahman, Homathevi, Qie, Lan, Psomas, Elizabeth, Prairie, Aaron, Poznansky, Frederica, Pillay, Rajeev, Picinali, Lorenzo, Pianzin, Annabel, Pfeifer, Marion, Parrett, Jonathan M., Noble, Ciar D., Nilus, Reuben, Mustaffa, Nazirah, Mullin, Katherine E., Mitchell, Simon, Mckinlay, Amelia R., Maunsell, Sarah, Matula, Radim, Massam, Michael, Martin, Stephanie, Malhi, Yadvinder, Majalap, Noreen, Maclean, Catherine S., Mackintosh, Emma, Luke, Sarah H., Lewis, Owen T., Layfield, Harry J., Lane-Shaw, Isolde, Kueh, Boon Hee, Kratina, Pavel, Konopik, Oliver, Kitching, Roger, Kinneen, Lois, Kemp, Victoria A., Jotan, Palasiah, Jones, Nick, Jebrail, Evyen W., Hroneš, Michal, Heon, Sui Peng, Hemprich-Bennett, David R., Haysom, Jessica K., Harianja, Martina F., Hardwick, Jane, Gregory, Nichar, Gray, Ryan, Gray, Ross E. J., Granville, Natasha, Gill, Richard, Fraser, Adam, Foster, William A., Folkard-Tapp, Hollie, Fletcher, Robert J., Fikri, Arman Hadi, Fayle, Tom M., Faruk, Aisyah, Eggleton, Paul, Edwards, David P., Drinkwater, Rosie, Dow, Rory A., Döbert, Timm F., Didham, Raphael K., Dickinson, Katharine J. M., Deere, Nicolas J., de Lorm, Tijmen, Dawood, Mahadimenakbar M., Davison, Charles W., Davies, Zoe G., Davies, Richard G., Dančák, Martin, Cusack, Jeremy, Clare, Elizabeth L., Chung, Arthur, Chey, Vun Khen, Chapman, Philip M., Cator, Lauren, Carpenter, Daniel, Carbone, Chris, Calloway, Kerry, Bush, Emma R., Burslem, David F. R. P., Brown, Keiron D., Brooks, Stephen J., Brasington, Ella, Brant, Hayley, Boyle, Michael J. W., Both, Sabine, Blackman, Joshua, Bishop, Tom R., Bicknell, Jake E., Bernard, Henry, Basrur, Saloni, Barclay, Maxwell V. L., Barclay, Holly, Atton, Georgina, Ancrenaz, Marc, Aldridge, David C., Daniel, Olivia Z., Reynolds, Glen, and Banks-Leite, Cristina
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- 2024
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32. Taxonomy based on science is necessary for global conservation.
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Scott A Thomson, Richard L Pyle, Shane T Ahyong, Miguel Alonso-Zarazaga, Joe Ammirati, Juan Francisco Araya, John S Ascher, Tracy Lynn Audisio, Valter M Azevedo-Santos, Nicolas Bailly, William J Baker, Michael Balke, Maxwell V L Barclay, Russell L Barrett, Ricardo C Benine, James R M Bickerstaff, Patrice Bouchard, Roger Bour, Thierry Bourgoin, Christopher B Boyko, Abraham S H Breure, Denis J Brothers, James W Byng, David Campbell, Luis M P Ceríaco, István Cernák, Pierfilippo Cerretti, Chih-Han Chang, Soowon Cho, Joshua M Copus, Mark J Costello, Andras Cseh, Csaba Csuzdi, Alastair Culham, Guillermo D'Elía, Cédric d'Udekem d'Acoz, Mikhail E Daneliya, René Dekker, Edward C Dickinson, Timothy A Dickinson, Peter Paul van Dijk, Klaas-Douwe B Dijkstra, Bálint Dima, Dmitry A Dmitriev, Leni Duistermaat, John P Dumbacher, Wolf L Eiserhardt, Torbjørn Ekrem, Neal L Evenhuis, Arnaud Faille, José L Fernández-Triana, Emile Fiesler, Mark Fishbein, Barry G Fordham, André V L Freitas, Natália R Friol, Uwe Fritz, Tobias Frøslev, Vicki A Funk, Stephen D Gaimari, Guilherme S T Garbino, André R S Garraffoni, József Geml, Anthony C Gill, Alan Gray, Felipe G Grazziotin, Penelope Greenslade, Eliécer E Gutiérrez, Mark S Harvey, Cornelis J Hazevoet, Kai He, Xiaolan He, Stephan Helfer, Kristofer M Helgen, Anneke H van Heteren, Francisco Hita Garcia, Norbert Holstein, Margit K Horváth, Peter H Hovenkamp, Wei Song Hwang, Jaakko Hyvönen, Melissa B Islam, John B Iverson, Michael A Ivie, Zeehan Jaafar, Morgan D Jackson, J Pablo Jayat, Norman F Johnson, Hinrich Kaiser, Bente B Klitgård, Dániel G Knapp, Jun-Ichi Kojima, Urmas Kõljalg, Jenő Kontschán, Frank-Thorsten Krell, Irmgard Krisai-Greilhuber, Sven Kullander, Leonardo Latella, John E Lattke, Valeria Lencioni, Gwilym P Lewis, Marcos G Lhano, Nathan K Lujan, Jolanda A Luksenburg, Jean Mariaux, Jader Marinho-Filho, Christopher J Marshall, Jason F Mate, Molly M McDonough, Ellinor Michel, Vitor F O Miranda, Mircea-Dan Mitroiu, Jesús Molinari, Scott Monks, Abigail J Moore, Ricardo Moratelli, Dávid Murányi, Takafumi Nakano, Svetlana Nikolaeva, John Noyes, Michael Ohl, Nora H Oleas, Thomas Orrell, Barna Páll-Gergely, Thomas Pape, Viktor Papp, Lynne R Parenti, David Patterson, Igor Ya Pavlinov, Ronald H Pine, Péter Poczai, Jefferson Prado, Divakaran Prathapan, Richard K Rabeler, John E Randall, Frank E Rheindt, Anders G J Rhodin, Sara M Rodríguez, D Christopher Rogers, Fabio de O Roque, Kevin C Rowe, Luis A Ruedas, Jorge Salazar-Bravo, Rodrigo B Salvador, George Sangster, Carlos E Sarmiento, Dmitry S Schigel, Stefan Schmidt, Frederick W Schueler, Hendrik Segers, Neil Snow, Pedro G B Souza-Dias, Riaan Stals, Soili Stenroos, R Douglas Stone, Charles F Sturm, Pavel Štys, Pablo Teta, Daniel C Thomas, Robert M Timm, Brian J Tindall, Jonathan A Todd, Dagmar Triebel, Antonio G Valdecasas, Alfredo Vizzini, Maria S Vorontsova, Jurriaan M de Vos, Philipp Wagner, Les Watling, Alan Weakley, Francisco Welter-Schultes, Daniel Whitmore, Nicholas Wilding, Kipling Will, Jason Williams, Karen Wilson, Judith E Winston, Wolfgang Wüster, Douglas Yanega, David K Yeates, Hussam Zaher, Guanyang Zhang, Zhi-Qiang Zhang, and Hong-Zhang Zhou
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Biology (General) ,QH301-705.5 - Published
- 2018
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33. Correction: Endoscopic Gold Fiducial Marker Placement into the Bladder Wall to Optimize Radiotherapy Targeting for Bladder-Preserving Management of Muscle-Invasive Bladder Cancer: Feasibility and Initial Outcomes.
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Maurice M Garcia, Alexander R Gottschalk, Jonathan Brajtbord, Badrinath R Konety, Maxwell V Meng, Mack Roach, and Peter R Carroll
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Medicine ,Science - Abstract
[This corrects the article DOI: 10.1371/journal.pone.0089754.].
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- 2016
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34. Risk of catecholamine crisis in patients undergoing resection of unsuspected pheochromocytoma
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Gina Song, Bonnie N. Joe, Benjamin M. Yeh, Maxwell V. Meng, Antonio C. Westphalen, and Fergus V. Coakley
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adrenal gland neoplasms ,imaging ,surgery ,pheochromocytoma ,catecholamines ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
PURPOSE: To report the risk of catecholamine crisis in patients undergoing resection of unsuspected pheochromocytoma. MATERIALS AND METHODS: Over a four-year period, we retrospectively identified four patients who underwent resection of adrenal pheochromocytoma in whom the diagnosis was unsuspected based on preoperative clinical, biochemical, and imaging evaluation. RESULTS: None of the patients exhibited preoperative clinical features of catecholamine excess. Preoperative biochemical screening in two patients was normal. CT scan performed in all patients demonstrated a nonspecific enhancing adrenal mass. During surgical resection of the adrenal mass, hemodynamic instability was observed in two of four patients, and one of these two patients also suffered a myocardial infarct. CONCLUSION: Both surgeons and radiologists should maintain a high index of suspicion for pheochromocytoma, as the tumor can be asymptomatic, biochemically negative, and have nonspecific imaging features. Resection of such unsuspected pheochromocytomas carries a substantial risk of intraoperative hemodynamic instability.
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- 2011
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35. Exhausted intratumoral Vδ2− γδ T cells in human kidney cancer retain effector function
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Rancan, Chiara, Arias-Badia, Marcel, Dogra, Pranay, Chen, Brandon, Aran, Dvir, Yang, Hai, Luong, Diamond, Ilano, Arielle, Li, Jacky, Chang, Hewitt, Kwek, Serena S, Zhang, Li, Lanier, Lewis L, Meng, Maxwell V, Farber, Donna L, and Fong, Lawrence
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Immunology ,Oncology and Carcinogenesis ,Kidney Disease ,Breast Cancer ,Clinical Research ,Cancer ,Underpinning research ,1.1 Normal biological development and functioning ,Aetiology ,2.1 Biological and endogenous factors ,Inflammatory and immune system ,Good Health and Well Being ,Humans ,CD8-Positive T-Lymphocytes ,Receptors ,Antigen ,T-Cell ,gamma-delta ,Programmed Cell Death 1 Receptor ,Kidney Neoplasms ,T-Lymphocyte Subsets ,Tumor Microenvironment ,Biochemistry and cell biology - Abstract
Gamma delta (γδ) T cells reside within human tissues including tumors, but their function in mediating antitumor responses to immune checkpoint inhibition is unknown. Here we show that kidney cancers are infiltrated by Vδ2- γδ T cells, with equivalent representation of Vδ1+ and Vδ1- cells, that are distinct from γδ T cells found in normal human tissues. These tumor-resident Vδ2- T cells can express the transcriptional program of exhausted αβ CD8+ T cells as well as canonical markers of terminal T-cell exhaustion including PD-1, TIGIT and TIM-3. Although Vδ2- γδ T cells have reduced IL-2 production, they retain expression of cytolytic effector molecules and co-stimulatory receptors such as 4-1BB. Exhausted Vδ2- γδ T cells are composed of three distinct populations that lack TCF7, are clonally expanded and express cytotoxic molecules and multiple Vδ2- T-cell receptors. Human tumor-derived Vδ2- γδ T cells maintain cytotoxic function and pro-inflammatory cytokine secretion in vitro. The transcriptional program of Vδ2- T cells in pretreatment tumor biopsies was used to predict subsequent clinical responses to PD-1 blockade in patients with cancer. Thus, Vδ2- γδ T cells within the tumor microenvironment can contribute to antitumor efficacy.
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- 2023
36. The natural history of a delayed detectable PSA after radical prostatectomy
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Szymaniak, Julie A., Washington, III, Samuel L., Cowan, Janet E., Cooperberg, Matthew R., Lonergan, Peter E., Nguyen, Hao G., Meng, Maxwell V., and Carroll, Peter R.
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- 2023
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37. Molecular Analysis of Upper Tract and Bladder Urothelial Carcinoma: Results from a Microarray Comparison.
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Thomas Sanford, Sima Porten, and Maxwell V Meng
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Medicine ,Science - Abstract
Prior studies have shown genetic similarities between upper tract and bladder urothelial carcinoma. However, upper tract urothelial carcinoma tends to be higher grade than bladder urothelial carcinoma and tends to form in patients with certain familial conditions (e.g. Lynch Syndrome), indicating there may be unique biologic processes in these tumors. The purpose of this study was to evaluate the differences in gene expression between upper tract and bladder urothelial carcinoma using microarray data.A search of publicly available microarray datasets identified a clinically annotated dataset of 12 upper tract and 20 bladder urothelial carcinoma specimens. Gene expression analysis of data derived from the Affymetrix HGU133Plus2 chip was performed. Bioconductor packages were used to evaluate clustering, differential gene expression, pathways relevant to oncology, and a basal/luminal signature in upper tract versus bladder urothelial carcinoma.When separated by pathologic T stage, there was evidence of differential clustering among pT3 tumors and significant gene expression differences in 81 genes. Pathway analysis revealed differences in HGF and TNF signaling pathways. Upper tract tumors tended to have high expression of genes associated with a luminal subtype. One of the genes most highly expressed in upper tract tumors, SLITRK6, is the target of an antibody drug conjugate (AGS15E) currently in phase I clinical trials.This study provides evidence for molecular differences between upper tract and bladder urothelial carcinoma, some of which contribute to oncologic-relevant pathways. Upper tract tumors tended to express genes consistent with a luminal subtype. We also identify a marker, SLITRK6, as a potential target for patients with advanced upper tract urothelial carcinoma.
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- 2015
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38. The effect of kidney morcellation on operative time, incision complications, and postoperative analgesia after laparoscopic nephrectomy
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Affonso H. Camargo, Jonathan N. Rubenstein, Brent D. Ershoff, Maxwell V. Meng, Christopher J. Kane, and Marshall L. Stoller
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nephrectomy ,laparoscopy ,pain ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
INTRODUCTION: Compare the outcomes between kidney morcellation and two types of open specimen extraction incisions, several covariates need to be taken into consideration that have not yet been studied. MATERIALS AND METHODS: We retrospectively reviewed 153 consecutive patients who underwent laparoscopic nephrectomy at our institution, 107 who underwent specimen morcellation and 46 with intact specimen removal, either those with connected port sites with a muscle-cutting incision and those with a remote, muscle-splitting incision. Operative time, postoperative analgesia requirements, and incisional complications were evaluated using univariate and multivariate analysis, comparing variables such as patient age, gender, body mass index (BMI), laterality, benign versus cancerous renal conditions, estimated blood loss, specimen weight, overall complications, and length of stay. RESULTS: There was no significant difference for operative time between the 2 treatment groups (p = 0.65). Incision related complications occurred in 2 patients (4.4%) from the intact specimen group but none in the morcellation group (p = 0.03). Overall narcotic requirement was lower in patients with morcellated (41 mg) compared to intact specimen retrieval (66 mg) on univariate (p = 0.03) and multivariate analysis (p = 0.049). Upon further stratification, however, there was no significant difference in mean narcotic requirement between the morcellation and muscle-splitting incision subgroup (p = 0.14). CONCLUSION: Morcellation does not extend operative time, and is associated with significantly less postoperative pain compared to intact specimen retrieval overall, although this is not statistically significant if a remote, muscle-splitting incision is made. Morcellation markedly reduces the risk of incisional-related complications.
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- 2006
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39. Endoscopic gold fiducial marker placement into the bladder wall to optimize radiotherapy targeting for bladder-preserving management of muscle-invasive bladder cancer: feasibility and initial outcomes.
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Maurice M Garcia, Alexander R Gottschalk, Jonathan Brajtbord, Badrinath R Konety, Maxwell V Meng, Mack Roach, and Peter R Carroll
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Medicine ,Science - Abstract
Bladder radiotherapy is a management option for carefully selected patients with muscle-invasive bladder cancer. However, the inability to visualize the tumor site during treatment and normal bladder movement limits targeting accuracy and increases collateral radiation. A means to accurately and reliably target the bladder during radiotherapy is needed.Eighteen consecutive patients with muscle-invasive bladder cancer (T1-T4) elected bladder-preserving treatment with maximal transurethral resection (TUR), radiation and concurrent chemotherapy. All underwent endoscopic placement of 24-K gold fiducial markers modified with micro-tines (70 [2.9×0.9 mm.]; 19 [2.1×0.7 mm.) into healthy submucosa 5-10 mm. from the resection margin, using custom-made coaxial needles. Marker migration was assessed for with intra-op bladder-filling cystogram and measurement of distance between markers. Set-up error and marker retention through completion of radiotherapy was confirmed by on-table portal imaging.Between 1/2007 and 7/2012, a total of 89 markers (3-5 per tumor site) were placed into 18 patients of mean age 73.6 years. Two patients elected cystectomy before starting treatment; 16/18 completed chemo-radiotherapy. All (100%) markers were visible with all on-table (portal, cone-beam CT), fluoroscopy, plain-film, and CT-scan imaging. In two patients, 1 of 4 markers placed at the tumor site fell-out (voided) during the second half of radiotherapy. All other markers (80/82, 98%) were present through the end of radio-therapy. No intraoperative (e.g. uncontrolled bleeding, collateral injury) or post-operative complications (e.g. stone formation, urinary tract infection, post-TUR hematuria >48 hours) occurred. Use of micro-tined fiducial tumor-site markers afforded a 2 to 6-fold reduction in bladder-area targeted with high-dose radiation.Placement of the micro-tined fiducial markers into the bladder was feasible and associated with excellent retention-rate and no complications. All markers were well-visualized during radiotherapy with all imaging modalities. Bladder fiducial markers improve targeting accuracy, and may increase treatment efficacy and reduce morbidity from collateral radiation.
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- 2014
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40. Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
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Qiao, Wenhui, Chen, Yixing, Zhong, Jun, Madden, Benjamin J., Charlesworth, Cristine M., Martens, Yuka A., Liu, Chia-Chen, Knight, Joshua, Ikezu, Tadafumi C., Aishe, Kurti, Zhu, Yiyang, Meneses, Axel, Rosenberg, Cassandra L., Kuchenbecker, Lindsey A., Vanmaele, Lucy K., Li, Fuyao, Chen, Kai, Shue, Francis, Dacquel, Maxwell V., Fryer, John, Pandey, Akhilesh, Zhao, Na, and Bu, Guojun
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- 2023
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41. Correction: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology
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Qiao, Wenhui, Chen, Yixing, Zhong, Jun, Madden, Benjamin J., Charlesworth, Cristine M., Martens, Yuka A., Liu, Chia-Chen, Knight, Joshua, Ikezu, Tadafumi C., Kurti, Aishe, Zhu, Yiyang, Meneses, Axel, Rosenberg, Cassandra L., Kuchenbecker, Lindsey A., Vanmaele, Lucy K., Li, Fuyao, Chen, Kai, Shue, Francis, Dacquel, Maxwell V., Fryer, John, Pandey, Akhilesh, Zhao, Na, and Bu, Guojun
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- 2023
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42. Holistic Characterization of Tumor Monocyte-to-Macrophage Differentiation Integrates Distinct Immune Phenotypes in Kidney Cancer
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Mujal, Adriana M, Combes, Alexis J, Rao, Arjun A, Binnewies, Mikhail, Samad, Bushra, Tsui, Jessica, Boissonnas, Alexandre, Pollack, Joshua L, Argüello, Rafael J, Meng, Maxwell V, Porten, Sima P, Ruhland, Megan K, Barry, Kevin C, Chan, Vincent, and Krummel, Matthew F
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Immunology ,Kidney Disease ,Human Genome ,Genetics ,Cancer ,Aetiology ,2.1 Biological and endogenous factors ,Animals ,Kidney Neoplasms ,Macrophages ,Mice ,Monocytes ,Phenotype ,Tumor Microenvironment ,Pharmacology and Pharmaceutical Sciences ,Oncology and carcinogenesis - Abstract
The tumor immune microenvironment (TIME) is commonly infiltrated by diverse collections of myeloid cells. Yet, the complexity of myeloid-cell identity and plasticity has challenged efforts to define bona fide populations and determine their connections to T-cell function and their relationship to patient outcome. Here, we have leveraged single-cell RNA-sequencing analysis of several mouse and human tumors and found that monocyte-macrophage diversity is characterized by a combination of conserved lineage states as well as transcriptional programs accessed along the differentiation trajectory. We also found in mouse models that tumor monocyte-to-macrophage progression was profoundly tied to regulatory T cell (Treg) abundance. In human kidney cancer, heterogeneity in macrophage accumulation and myeloid composition corresponded to variance in, not only Treg density, but also the quality of infiltrating CD8+ T cells. In this way, holistic analysis of monocyte-to-macrophage differentiation creates a framework for critically different immune states.
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- 2022
43. Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
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Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick, Hague, Rosie, Pollock, Louisa, Semple, Malcolm G, Peto, Leon, Baillie, J Kenneth, Buch, Maya, Jeffery, Katie, Knight, Marian, Lim, Wei Shen, Montgomery, Alan, Mukherjee, Aparna, Mumford, Andrew, Rowan, Kathryn, Thwaites, Guy, Mafham, Marion, Emberson, Jonathan, Landray, Martin J, Horby, Peter W, Chappell, Lucy, Day, Jeremy, Dung, DV, Quang, NN, Binh, Prof, Burhan, E, Alisjahbana, B, Koirala, J, Basnet, S, Kestelyn, E, Basnyat, B, Gyanwali, P, Hamers, RL, Sandercock, P, Darbyshire, J, DeMets, D, Fowler, R, Lalloo, D, Munavvar, M, Roberts, I, Warris, A, Wittes, J, Craddock-Bamford, A, Barton, J, Basoglu, A, Brown, R, Brudlo, W, Denis, E, Fletcher, L, Howard, S, Musini, S, Taylor, K, Cui, G, Goodenough, B, King, A, Lay, M, Murray, D, Stevens, W, Wallendszus, K, Welsh, R, Crichton, C, Davies, J, Goldacre, R, Harper, C, Knight, F, Nunn, M, Salih, H, Welch, J, Campbell, M, Pessoa-Amorim, G, Zayed, M, Wiles, J, Bagley, G, Cameron, S, Chamberlain, S, Farrell, B, Freeman, H, Kennedy, A, Whitehouse, A, Wilkinson, S, Wood, C, Reith, C, Davies, K, Halls, H, Holland, L, Truell, R, Wilson, K, Lingwood, Emma, Howie, L, Lunn, M, Rodgers, Penelope, Amuasi, J, Baird, K, Bao, T, Bittaye, M, Bonney, J, D'Alessandro, U, Dhimal, M, Huyen, T, Jagne, A, Karkey, A, Maiga, O, Matey, E, Nadjm, B, Nel, J, Pant, S, Puspatriani, K, Rahardjani, M, Raijal, S, Rees, H, Rimainar, A, Roberts, C, Rocca, A, Shrestha, S, Usuf, E, Vidaillic, C, Wulandari, F, Alexander, A, Amezaga, M, Armah, C, Asghar, A, Aubrey, P, Barker-Williams, K, Barnard, A, Bartholomew, J, Beaumont-Jewell, D, Beddows, S, Beety, J, Birch, C, Boyle, P, Brend, M, Brookes, M, Callens, C, Campbell, D, Campbell, H, Cate, H, Chambers, E, Chapman, K, Coe, A, Collins, J, Crawshaw, S, Das, S, De Soyza, A, Denton, E, Dicks, P, Dolman, M, Donaldson, K, Dowden, L, Dowling, S, Drake, C, Duckles-Leech, H, Duffy, H, Gerdes, L, Gibbons, K, Gill, L, Gilmour, K, Goodwin, J, Graham, J, Green, C, Hall, C, Hall, A, Hampshire, K, Hanson, J, Harman, T, Harper, H, Harrison, S, Hicks, J, Hodgson, H, Hough, M, Jackson, S, Johnson, G, Kirk, J, Lemoine, N, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, McMillan, N, Membrey, H, Mguni, N, Minton, J, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, Nickson, I, Odam, M, Ohia, U, Okell, E, Oliver, A, Pearson, K, Pine, K, Pleass, R, Porter, D, Porter, L, Potter, A, Poustie, V, Pratt, S, Price, A, Priest, A, Rodgers, A, Rook, C, Ryan, P, Sam, S, Sharratt, P, Sheffield, J, Shenton, J, Shirley, K, Skinner, T, Slade, H, Sutu, M, Taylor, J, Thomas, E, Tinkler, H, Unsworth, A, Usher, R, van't Hoff, W, Walker, S, Walters, J, Walton, E, Warmington, J, Wayman, E, Williams, P, Williamson, J, Williamson, D, Yelnoorkar, F, Knight, M, Hodson, K, Pavord, S, Williamson, C, Bowman, L, Chen, F, Clarke, R, Goonasekara, M, Herrington, W, Judge, P, Ng, S, Preiss, D, Sammons, E, Zhu, D, Arkley, C, Bowker, P, Bruce, J, Byrne-Watts, V, Chapman, G, Coleman, G, Denwood, T, Gray, J, Harrison, D, Mather, N, Pinches, H, Rees, A, Rees, S, Turner, G, Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Aboaba, A, Aboagye-Odei, A, Aboelela, H, Abo-Leyah, 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Whitmore, D, Whittam, L, Whittington, A, Whittle, H, Whittle, R, Wiafe, E, Wiblin, L, Wickens, O, Widdrington, J, Wieboldt, J, Wieringa, H, Wiesender, C, Wiffen, L, Wight, A, Wignall, A, Wignall, C, Wilce, A, Wilcock, D, Wilcock, E, Wilcox, L, Wild, B, Wild, L, Wild, S, Wilde, M, Wilding, L, Wilding, P, Wildsmith, T, Wileman, J, Wiles, K, Wilhelmsen, E, Wiliams, T, Wilkie, J, Wilkin, D, Wilkins, H, Wilkins, J, Wilkins, S, Wilkinson, I, Wilkinson, L, Wilkinson, N, Wilkinson, T, Willetts, S, Williams, A, Williams, C, Williams, D, Williams, E, Williams, G, Williams, H, Williams, J, Williams, K, Williams, M, Williams, R, Williams, S, Williams, T, Williamson, A, Williamson, H, Williamson, R, Willis, E, Willis, H, Willis, J, Wills, L, Willsher, L, Willshire, C, Wilson, A, Wilson, B, Wilson, D, Willson, F, Wilson, I, Willson, J, Wilson, K-A, Wilson, L, Wilson, M, Wilson, T, Win, K, Win, M, Win, T, Win, W, Winckworth, L, Winder, L, Winder, P, Winearl, S, Winmill, H, Winn, S, Winpenny, C, Winslow, H, Winter, H, Winter, J, Winter-Goodwin, B, Winterton, J, Winwood, H, Wischhusen, J, Wisdom, S, Wise, M, Wiselka, M, Wiseman, R, Wiseman, S, Wishart, S, Wishlade, T, Witele, E, Withers, N, Wixted, D, Wodehouse, T, Wolf, W, Wolff, N, Wolffsohn, K, Wolf-Roberts, R, Wolodimeroff, E, Wolstencroft, A, Wong, A, Wong, C, Wong, C H, Wong, E, Wong, J, Wong, K, Wong, M, Wong, N, Wong, S, Wong, T, Wood, A, Wood, D, Wood, F, Wood, G, Wood, H, Wood, J, Wood, L, Wood, M, Wood, S, Wood, T, Woodall, K, Woodfield, R, Woodford, C, Woodford, E, Woodford, J, Woodhead, L, Woodhead, T, Woodland, P, Woodman, M, Woodmansey, S, Woods, C, Woods, J, Woods, K, Woods, S, Woodward, Z, Woolcock, M, Wooldridge, G, Woolf, R, Woollard, C, Woollen, L, Woolley, E, Woolley, J, Woosey, D, Wootton, D, Wootton, J, Worley, D, Worton, S, Wraight, J, Wray, M, Wren, K, Wren, L, Wrey Brown, C, Wright, C, Wright, D, Wright, F, Wright, H, Wright, I, Wright, L, Wright, R, Wright, S, Wright, T, Wroe, C, Wroe, H, Wu, H, Wu, P, Wubetu, J, Wulandari, R, Wurie, S, Wyatt, C, Wyn-Griffiths, F, Wynter, I, Xavier, B, Xhikola, A, Xia, B, Xia, Z, Y Ellis, T, Yacoba, E, Yakubi, M, Yan, M, Yanagisawa, Y, Yang, F, Yang, Y, Yanney, M, Yap, W, Yaqoob, N, Yasmin, S, Yates, B, Yates, D, Yates, E, Yates, H, Yates, M, Yates, T, Ye, J, Yearwood Martin, C, Yein, K, Yeoh, A, Yeung, C, Yew, P, Yewatkar, D, Ylquimiche Melly, L, Ynter, I, Yong, H, Yorke, J, Youens, J, Younes Ibrahim, A, Young, E, Young, G, Young, L, Yousafzar, A, Youssouf, S, Yousuf, A, Yu, C, Yuan, J, Yung, B, Yusef, D, Yusef, S, Yusuf, I, Zafar, A-M, Zagalo, S, Zaher, S, Zahoor, A, Zainab, M, Zak, T, Zaki, K, Zakir, N, Zalewska, K, Zamalloa, A, Zaman, M, Zaman, S, Zamikula, J, Zammit, L, Zammit-Mangion, M, Zawadzka, M, Zebracki, E, Zehnder, D, Zeidan, L, Zeinali, D, Zhang, J, Zhao, X, Zheng, D, Zia, M, Zibdeh, O, Zill-E-Huma, R, Zin, E, Zincone, E, Zindoga, G, Zinkin, E, Zinyemba, V, Zipitis, C, Zitter, L, Zmierczak, A, Zubikarai, G, Zubir, A, Zuhra, N, Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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- 2024
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44. Spectroscopy of $A=9$ hyperlithium by the $(e,e^{\prime}K^{+})$ reaction
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Gogami, T., Chen, C., Kawama, D., Achenbach, P., Ahmidouch, A., Albayrak, I., Androic, D., Asaturyan, A., Asaturyan, R., Ates, O., Baturin, P., Badui, R., Boeglin, W., Bono, J., Brash, E., Carter, P., Chiba, A., Christy, E., Danagoulian, S., De Leo, R., Doi, D., Elaasar, M., Ent, R., Fujii, Y., Fujita, M., Furic, M., Gabrielyan, M., Gan, L., Garibaldi, F., Gaskell, D., Gasparian, A., Han, Y., Hashimoto, O., Horn, T., Hu, B., Hungerford, Ed. V., Jones, M., Kanda, H., Kaneta, M., Kato, S., Kawai, M., Khanal, H., Kohl, M., Liyanage, A., Luo, W., Maeda, K., Margaryan, A., Markowitz, P., Maruta, T., Matsumura, A., Maxwell, V., Meekins, D., Mkrtchyan, A., Mkrtchyan, H., Nagao, S., Nakamura, S. N., Narayan, A., Neville, C., Niculescu, G., Niculescu, M. I., Nunez, A., Nuruzzaman, Okayasu, Y., Petkovic, T., Pochodzalla, J., Qiu, X., Reinhold, J., Rodriguez, V. M., Samanta, C., Sawatzky, B., Seva, T., Shichijo, A., Tadevosyan, V., Tang, L., Taniya, N., Tsukada, K., Veilleux, M., Vulcan, W., Wesselmann, F. R., Wood, S. A., Yamamoto, T., Ya, L., Ye, Z., Yokota, K., Yuan, L., Zhamkochyan, S., and Zhu, L.
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Nuclear Experiment - Abstract
Missing mass spectroscopy with the $(e,e^{\prime}K^{+})$ reaction was performed at Jefferson Laboratory's Hall C for the neutron rich $\Lambda$ hypernucleus $^{9}_{\Lambda}{\rm Li}$. The ground state energy was obtained to be $B_{\Lambda}^{\rm g.s.}=8.84\pm0.17^{\rm stat.}\pm0.15^{\rm sys.}~{\rm MeV}$ by using shell model calculations of a cross section ratio and an energy separation of the spin doublet states ($3/2^{+}_1$ and $5/2^{+}_1$). In addition, peaks that are considered to be states of [$^{8}{\rm Li}(3^{+})\otimes s_{\Lambda}=3/2^{+}_{2}, 1/2^{+}$] and [$^{8}{\rm Li}(1^{+})\otimes s_{\Lambda}=5/2^{+}_{2}, 7/2^{+}$] were observed at $E_{\Lambda}({\rm no.~2})=1.74\pm0.27^{\rm stat.}\pm0.11^{\rm sys.}~{\rm MeV}$ and $E_{\Lambda}({\rm no.~3})=3.30\pm0.24^{\rm stat.}\pm0.11^{\rm sys.}~{\rm MeV}$, respectively. The $E_{\Lambda}({\rm no.~3})$ is larger than shell model predictions by a few hundred keV, and the difference would indicate that a ${\rm ^{5}He}+t$ structure is more developed for the $3^{+}$ state than those for the $2^{+}$ and $1^{+}$ states in a core nucleus $^{8}{\rm Li}$ as a cluster model calculation suggests., Comment: 5 pages, 3 figures
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- 2021
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45. Heterogeneity in NECTIN4 Expression Across Molecular Subtypes of Urothelial Cancer Mediates Sensitivity to Enfortumab Vedotin
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Chu, Carissa E, Sjöström, Martin, Egusa, Emily A, Gibb, Ewan A, Badura, Michelle L, Zhu, Jun, Koshkin, Vadim S, Stohr, Bradley A, Meng, Maxwell V, Pruthi, Raj S, Friedlander, Terence W, Lotan, Yair, Black, Peter C, Porten, Sima P, Feng, Felix Y, and Chou, Jonathan
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Clinical Research ,Cancer ,Biotechnology ,Urologic Diseases ,Development of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Good Health and Well Being ,Antibodies ,Monoclonal ,Carcinoma ,Transitional Cell ,Cell Adhesion Molecules ,Female ,Gene Expression Regulation ,Neoplastic ,Humans ,Immunoconjugates ,Tumor Cells ,Cultured ,Urinary Bladder Neoplasms ,Oncology & Carcinogenesis ,Clinical sciences ,Oncology and carcinogenesis - Abstract
PurposeEnfortumab vedotin (EV) is an antibody-drug conjugate (ADC) targeting NECTIN4 (encoded by the PVRL4/NECTIN4 gene) approved for treatment-refractory metastatic urothelial cancer. Factors that mediate sensitivity or resistance to EV are unknown. In this study, we sought to (i) examine heterogeneity of NECTIN4 gene expression across molecular subtypes of bladder cancer and (ii) determine whether NECTIN4 expression mediates EV sensitivity or resistance.Experimental designMolecular subtyping and NECTIN4 expression data from seven muscle-invasive bladder cancer clinical cohorts (n = 1,915 total specimens) were used to assess NECTIN4 expression across molecular subtypes. The outcome of the transcriptomic analysis was relative NECTIN4 expression in the consensus molecular subtypes of bladder cancer. Expression of NECTIN4 was validated in bladder cancer cell lines. NECTIN4 was stably overexpressed or knocked down in basal and luminal bladder cancer cell lines and EV drug sensitivity assays were performed, as measured by cell proliferation and clonogenic assays.ResultsNECTIN4 expression is heterogenous across molecular subtypes of bladder cancer and significantly enriched in luminal subtypes. NECTIN4 expression is positively correlated with luminal markers GATA3, FOXA1, and PPARG across all cohorts. NECTIN4 expression is both necessary and sufficient for EV sensitivity in luminal and basal subtypes of urothelial bladder cancer cells. Downregulation of NECTIN4 leads to EV resistance.ConclusionsSensitivity to EV is mediated by expression of NECTIN4, which is enriched in luminal subtypes of bladder cancer. These findings may have implications for biomarker development, patient selection, and the inclusion of molecular subtyping in ongoing and future EV clinical trials.See related commentary by Teo and Rosenberg, p. 4950.
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- 2021
46. Metabolic imaging with hyperpolarized 13C pyruvate magnetic resonance imaging in patients with renal tumors—Initial experience
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Tang, Shuyu, Meng, Maxwell V, Slater, James B, Gordon, Jeremy W, Vigneron, Daniel B, Stohr, Bradley A, Larson, Peder EZ, and Wang, Zhen Jane
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Kidney Disease ,Rare Diseases ,Clinical Research ,Digestive Diseases ,Cancer ,Biomedical Imaging ,Carcinoma ,Renal Cell ,Humans ,Kidney Neoplasms ,Magnetic Resonance Imaging ,Pyruvic Acid ,Reproducibility of Results ,hyperpolarized C-13 ,lactate ,magnetic resonance imaging ,molecular ,pyruvate ,renal cell carcinoma ,hyperpolarized 13C ,Public Health and Health Services ,Oncology & Carcinogenesis ,Oncology and carcinogenesis ,Public health - Abstract
BackgroundOptimal treatment selection for localized renal tumors is challenging because of their variable biologic behavior and limitations in the preoperative assessment of tumor aggressiveness. The authors investigated the emerging hyperpolarized (HP) 13 C magnetic resonance imaging (MRI) technique to noninvasively assess tumor lactate production, which is strongly associated with tumor aggressiveness.MethodsEleven patients with renal tumors underwent HP 13 C pyruvate MRI before surgical resection. Tumor 13 C pyruvate and 13 C lactate images were acquired dynamically. Five patients underwent 2 scans on the same day to assess the intrapatient reproducibility of HP 13 C pyruvate MRI. Tumor metabolic data were compared with histopathology findings.ResultsEight patients had tumors with a sufficient metabolite signal-to-noise ratio for analysis; an insufficient tumor signal-to-noise ratio was noted in 2 patients, likely caused by poor tumor perfusion and, in 1 patient, because of technical errors. Of the 8 patients, 3 had high-grade clear cell renal cell carcinoma (ccRCC), 3 had low-grade ccRCC, and 2 had chromophobe RCC. There was a trend toward a higher lactate-to-pyruvate ratio in high-grade ccRCCs compared with low-grade ccRCCs. Both chromophobe RCCs had relatively high lactate-to-pyruvate ratios. Good reproducibility was noted across the 5 patients who underwent 2 HP 13 C pyruvate MRI scans on the same day.ConclusionsThe current results demonstrate the feasibility of HP 13 C pyruvate MRI for investigating the metabolic phenotype of localized renal tumors. The initial data indicate good reproducibility of metabolite measurements. In addition, the metabolic data indicate a trend toward differentiating low-grade and high-grade ccRCCs, the most common subtype of renal cancer.Lay summaryRenal tumors are frequently discovered incidentally because of the increased use of medical imaging, but it is challenging to identify which aggressive tumors should be treated. A new metabolic imaging technique was applied to noninvasively predict renal tumor aggressiveness. The imaging results were compared with tumor samples taken during surgery and showed a trend toward differentiating between low-grade and high-grade clear cell renal cell carcinomas, which are the most common type of renal cancers.
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- 2021
47. Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Abidin, A, Aboaba, A, Aboagye-Odei, A, Aboah, C, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, HJ, Abu-Arafeh, A, Abubacker, SM, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, F, Acheampong, P, Acheampong, S, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, AS, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adatia, K, Adcock, K, Addai-Boampong, L, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, FW, Adesemoye, OA, Adewunmi, EO, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikari, B, Adhikari, SA, Adhikary, R, Aditya, A, Adjepong, P, Adkins, G, Adnan, A, Adriaanse, M, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Afrim, P, Afriyie, FA, Aftab, ZA, Afum-Adjei Awuah, A, Agarwal, M, Agasiya, PN, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Agyekum, JA, Agyen, K, Ahadome, EK, Ahamed Sadiq, S, Ahammed Nazeer, MH, Ahmad, M, Ahmad, S, Ahmed, A, Ahmed, BAR, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, Ahmed, K, Ahmed, L, Ahmed, M, Ahmed, MC, Ahmed, MS, Ahmed, N, Ahmed, O, Ahmed, RA, Ahmed, R, Ahmed, S, Ahmed, SG, Ahmed, SH, Ahmed Ali, R, Ahmed Mohamud, B, Ahmer, S, Ahonia, A, Aidoo, C, Aiken, C, Ail, D, Ainsworth, M, Aissa, M, Aitken, L, Ajay, B, Ajibode, A, Ajmi, A, Akhtar, N, Akili, S, Akinbiyi, B, Akindolie, O, Akinfenwa, Y, Akinkugbe, O, Akinpelu, I, Akram, M, Aktinade, O, Akudi, U, Al Aaraj, ASAR, Al Balushi, A, Al Dakhola, M, Al Swaifi, A, Al-Abadi, E, Alabi, A, Aladangady, N, Alafifi, M, Alam, A, Alam, S, Al-Asadi, A, Alatzoglou, K, Albert, P, Albertus, A, Albon, L, Alcala, A, Alcorn, G, Alcorn, S, Aldana, A, Alderdice, D, Aldesouki, A, Aldouri, R, Aldridge, J, Aldridge, N, Ale, RM, Alegria, A, Alexander, A, Alexander, C, Alexander, J, Alexander, PDG, Al-fori, J, Alghazawi, L, Alhabsha, O, Al-Hakim, B, Alhameed, R, Al-Hayali, M, Al-Hity, S, Ali, A, Ali, FR, Ali, J, Ali, M, Ali, MS, Ali, N, Ali, O, Ali, R, Ali, S, Aliberti, E, Alin, J, Alina, A, Alipustain, A, Alisjahbana, B, Aliyuda, F, Alizadeh, K, Al-Jibury, M, Al-Juboori, S, Al-Khalil, M, Alkhudhayri, A, Alkhusheh, M, Allan, F, Allan, N, Allanson, A, Allcock, R, Allen, E, Allen, J, Allen, K, Allen, L, Allen, P, Allen, R, Allen, S, Allen, T, Alli, A, Allison, K, Allman, B, Allsop, HK, Allsop, L, Allsup, D, Almahroos, AFT, Al-Moasseb, H, Al-Obaidi, M, Alomari, L, Al-Rabahi, A, Al-Ramadhani, B, Al-Saadi, Z, Al-Sammarraie, R, Alshaer, I, Al-Shahi Salman, R, Al-Shamkhani, W, Alsheikh, F, Al-Sheklly, B, Altaf, S, Alty, A, Alvarez, M, Alvarez Corral, M, Alveyn, E, Alzetani, M, Amamou, S, Amar, N, Ambalavanan, S, Ambrogetti, R, Ambrose, C, Ameen, A, Amelia Ganefianty, A, Ames, K, Amezaga, MR, Amin, A, Amin, K, Amin, S, Amin, T, Amit, B, Amjad, A, Amjad, N, Amoah-Dankwa, J, Amoako-Adusei, A, Amosun, V, Amsal, M, Amsha, K, Amuasi, J, Amutio Martin, N, Amy, P, Anada, A, Anand, A, Anandappa, S, Anantapatnaikuni, SD, Andari, NKN, Anderson, E, Anderson, J, Anderson, L, Anderson, M, Anderson, N, Anderson, R, Anderson, S, Anderson, W, Andreou, P, Andrews, A, Andrews, J, Aneke, K, Ang, A, Ang, WW, Angel, T, Angela, A, Angelini, P, Anguvaa, L, Anichtchik, O, Anim-Somuah, M, Aniruddhan, K, Annett, J, Anning, L, Ansah, M, Anstey, PJ, Anstey, R, Anthony, A, Anthony-Pillai, A, Antill, P, Antonina, Z, Anu, V, Anwar, M, Anwar, S, Apetri, E, Apostolopoulos, A, Appleby, S, Appleyard, D, Aquino, MF, Araba, B, Aransiola, S, Araujo, M, Archer, A, Archer, D, Archer, S, Arcoria, D, Ardley, C, Arhin-Sam, G, Arias, A-M, Aribike, O, Arimoto, R, Arisanti, NLPE, Arkley, C, Armah, C, Armata, I, Armistead, J, Armitage, A, Armstrong, C, Armstrong, M, Armstrong, S, Armstrong, W, Armtrong, P, Arndt, H, Arnison-Newgass, C, Arnold, D, Arnold, R, Arnott, A, Arora, D, Arora, K, Arora, P, Arora, R, Arter, A, Arthur, A, Artini, NM, Arumaithurai, A, Arya, A, Arya, R, Aryal, D, Asandei, D, Asare, GA, Asghar, A, Asghar, M, Ashab, A, Ashbrook-Raby, C, Ashby, H, Ashcroft, J, Ashcroft, S, Asher, G, Ashfak, Z, Ashfaq, A, Asiamah, HA, Ashish, A, Ashley, D, Ashman-Flavell, S, Ashok, S, Ashour, A-E-A, Ashraf, MZ, Ashraf, S, Ashraq, MB, Ashton, D, Ashton, S, Ashworth, A, Ashworth, FJ, Ashworth, R, Aslam, A, Aslam, I, Aslam, S, Aslett, L, Asogan, H, Asrar, A, Assaf, O, Astin-Chamberlain, R, Atabudzi, YE, Athavale, P, Athorne, D, Atkins, B, Atkins, C, Atkins, S, Atkinson, J, Atkinson, V, Atomode, A, Atraskiewicz, B, Attia, AA, Attubato, E, Attwood, M, Aubrey, P, Auer, Z, Aujayeb, A, Aung, AT, Aung, H, Aung, HWW, Aung, KK, Aung, KT, Aung, N, Aung, Y, Aung, ZM, Austin, E, Austin, K, Auwal, A, Avari, M, Avery, M, Aveyard, N, Avis, J, Aviss, G, Avram, C, Avram, P, Awadelkareem, A, Awadzi, G, Awaly, M, Awan, A, Awisi, S, Aya, A, Ayaz, E, Ayerh, JM, Ayers, A, Azam, J, Azeem, A, Azharuddin, M, Aziz, A, Aziz, G, Aziz, I, Aziz, N, Azkoul, A, Azman Shah, A, Azzopardi, G, Azzoug, H, Babatunde, F, Babi, M, Babiker, B, Babington, G, Babirecki, M, Babores, M, Babs-Osibodu, AO, Bac, T, Bacciarelli, S, Bachar, R, Bachour, M-E, Bachti, A, Bacon, G, Bacon, J, Badal, B, Badat, A, Bader, M, Badhan, GR, Badhrinarayanan, S, Bae, JP, Baggaley, A, Baggott, A, Bagley, G, Bagmane, D, Bagshaw, L, Bahadori, K, Bahurupi, Y, Bailey, A, Bailey, J, Bailey, K, Bailey, L, Bailey, MA, Bailey, M, Bailey, P, Bailey, S, Baillie, H, Baillie, JK, Bain, J, Bains, V, Baird, D, Baird, E, Baird, K, 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- 2023
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48. Adjuvant everolimus after surgery for renal cell carcinoma (EVEREST): a double-blind, placebo-controlled, randomised, phase 3 trial
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Ryan, Christopher W, Tangen, Catherine M, Heath, Elisabeth I, Stein, Mark N, Meng, Maxwell V, Alva, Ajjai S, Pal, Sumanta K, Puzanov, Igor, Clark, Joseph I, Choueiri, Toni K, Agarwal, Neeraj, Uzzo, Robert G, Haas, Naomi B, Synold, Timothy W, Plets, Melissa, Vaishampayan, Ulka N, Shuch, Brian M, Thompson, Ian M, Jr, and Lara, Primo N, Jr
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- 2023
- Full Text
- View/download PDF
49. Evaluating the impact of surgical supply cost variation during partial nephrectomy on patient outcomes
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Balakrishnan, Ashwin S, Hampson, Lindsay A, Bell, Alexander M, Baghdanian, Arthur H, Baghdanian, Armonde A, Meng, Maxwell V, and Odisho, Anobel Y
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Biomedical and Clinical Sciences ,Clinical Sciences ,Patient Safety ,Clinical Research ,Evaluation of treatments and therapeutic interventions ,6.4 Surgery ,Cost analysis ,partial nephrectomy ,surgical supplies ,quality improvement ,urologic oncology ,Clinical sciences ,Reproductive medicine - Abstract
BackgroundReducing surgical supply costs can help to lower hospital expenditures. We aimed to evaluate whether variation in supply costs between urologic surgeons performing both robotic or open partial nephrectomies is associated with differential patient outcomes.MethodsIn this retrospective cohort study, we reviewed 399 consecutive robotic (n=220) and open (n=179) partial nephrectomies performed at an academic center. Surgical supply costs were determined at the institution-negotiated rate. Through retrospective review, we identified factors related to case complexity, patient comorbidity, and perioperative outcomes. Two radiologists assigned nephrometry scores to grade tumor complexity. We created univariate and multivariable models for predictors of supply costs, length of stay, and change in serum creatinine.ResultsMedian supply cost was $3,201 [interquartile range (IQR): $2,201-3,808] for robotic partial nephrectomy and $968 (IQR: $819-1,772) for open partial nephrectomy. Mean nephrometry score was 7.0 (SD =1.7) for robotic procedures and 8.2 (SD =1.6) for open procedures. In multivariable models, the surgeon was the primary significant predictor of variation in surgical supply costs for both procedure types. In multivariable mixed-effects analysis with surgeon as a random effect, supply cost was not a significant predictor of change in serum creatinine for robotic or open procedures. Supply cost was not a statistically significant predictor of length of stay for the open procedure. Supply cost was a significant predictor of longer length of stay for the robotic procedure, however it was not a clinically meaningful change in length of stay (0.02 days per $100 in supply costs).ConclusionsHigher supply spending did not predict significantly improved patient outcomes. Variability in surgeon supply preference is the likely source of variability in supply cost. These data suggest that efforts to promote cost-effective utilization and standardization of supplies in partial nephrectomy could help reduce costs without harming patients.
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- 2021
50. A comparison of stage-specific all-cause mortality between testicular sex cord stromal tumors and germ cell tumors: results from the National Cancer Database
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Zuniga, Kyle B, Washington, Samuel L, Porten, Sima P, and Meng, Maxwell V
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Reproductive Medicine ,Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Clinical Research ,Rare Diseases ,Cancer ,Good Health and Well Being ,Adult ,Databases ,Factual ,Humans ,Male ,Middle Aged ,Neoplasms ,Germ Cell and Embryonal ,Retrospective Studies ,Sex Cord-Gonadal Stromal Tumors ,Survival Rate ,Testicular Neoplasms ,United States ,Testicular neoplasms ,Leydig cell tumors ,Sertoli cell tumors ,Sex cord-gonadal stromal tumors ,Testicular germ cell tumors ,Clinical Sciences ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundTesticular sex cord stromal tumors (SCSTs) are managed similarly to germ cell tumors (GCTs); however, few studies have directly compared outcomes between these tumor types. Using the National Cancer Database (NCDB), we sought to compare overall and stage-specific all-cause mortality (ACM) between SCSTs versus GCTs.MethodsNCDB was queried for patients diagnosed with SCSTs and GCTs between 2004 and 2013. Descriptive statistics were used to compare sociodemographic and clinical characteristics between groups. Univariable and multivariable Cox proportional hazards regression analyses were used to assess associations with ACM.ResultsWe identified 42,192 patients diagnosed with testicular cancer between 2004 and 2013, with 280 having SCSTs and 41,912 patients having GCTs. Median age for SCSTs and GCTs was 45 (interquartile range [IQR] 34-59) and 34 (IQR 27-43), respectively (p
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- 2020
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