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777 results on '"Maxwell, Patrick H"'

1. A spatiotemporal atlas of mouse liver homeostasis and regeneration

Author

Xu, Jiangshan, Guo, Pengcheng, Hao, Shijie, Shangguan, Shuncheng, Shi, Quan, Volpe, Giacomo, Huang, Keke, Zuo, Jing, An, Juan, Yuan, Yue, Cheng, Mengnan, Deng, Qiuting, Zhang, Xiao, Lai, Guangyao, Nan, Haitao, Wu, Baihua, Shentu, Xinyi, Wu, Liang, Wei, Xiaoyu, Jiang, Yujia, Huang, Xin, Pan, Fengyu, Song, Yumo, Li, Ronghai, Wang, Zhifeng, Liu, Chuanyu, Liu, Shiping, Li, Yuxiang, Yang, Tao, Xu, Zhicheng, Du, Wensi, Li, Ling, Ahmed, Tanveer, You, Kai, Dai, Zhen, Li, Li, Qin, Baoming, Li, Yinxiong, Lai, Liangxue, Qin, Dajiang, Chen, Junling, Fan, Rong, Li, Yongyin, Hou, Jinlin, Ott, Michael, Sharma, Amar Deep, Cantz, Tobias, Schambach, Axel, Kristiansen, Karsten, Hutchins, Andrew P., Göttgens, Berthold, Maxwell, Patrick H., Hui, Lijian, Xu, Xun, Liu, Longqi, Chen, Ao, Lai, Yiwei, and Esteban, Miguel A.

Published
2024
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4. Live birth of chimeric monkey with high contribution from embryonic stem cells

Author

Cao, Jing, Li, Wenjuan, Li, Jie, Mazid, Md. Abdul, Li, Chunyang, Jiang, Yu, Jia, Wenqi, Wu, Liang, Liao, Zhaodi, Sun, Shiyu, Song, Weixiang, Fu, Jiqiang, Wang, Yan, Lu, Yong, Xu, Yuting, Nie, Yanhong, Bian, Xinyan, Gao, Changshan, Zhang, Xiaotong, Zhang, Liansheng, Shang, Shenshen, Li, Yunpan, Fu, Lixin, Liu, Hao, Lai, Junjian, Wang, Yang, Yuan, Yue, Jin, Xin, Li, Yan, Liu, Chuanyu, Lai, Yiwei, Shi, Xuyang, Maxwell, Patrick H., Xu, Xun, Liu, Longqi, Poo, Muming, Wang, Xiaolong, Sun, Qiang, Esteban, Miguel A., and Liu, Zhen

Published
2023
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5. Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays

Author

Chen, Ao, Liao, Sha, Cheng, Mengnan, Ma, Kailong, Wu, Liang, Lai, Yiwei, Qiu, Xiaojie, Yang, Jin, Xu, Jiangshan, Hao, Shijie, Wang, Xin, Lu, Huifang, Chen, Xi, Liu, Xing, Huang, Xin, Li, Zhao, Hong, Yan, Jiang, Yujia, Peng, Jian, Liu, Shuai, Shen, Mengzhe, Liu, Chuanyu, Li, Quanshui, Yuan, Yue, Wei, Xiaoyu, Zheng, Huiwen, Feng, Weimin, Wang, Zhifeng, Liu, Yang, Wang, Zhaohui, Yang, Yunzhi, Xiang, Haitao, Han, Lei, Qin, Baoming, Guo, Pengcheng, Lai, Guangyao, Muñoz-Cánoves, Pura, Maxwell, Patrick H., Thiery, Jean Paul, Wu, Qing-Feng, Zhao, Fuxiang, Chen, Bichao, Li, Mei, Dai, Xi, Wang, Shuai, Kuang, Haoyan, Hui, Junhou, Wang, Liqun, Fei, Ji-Feng, Wang, Ou, Wei, Xiaofeng, Lu, Haorong, Wang, Bo, Liu, Shiping, Gu, Ying, Ni, Ming, Zhang, Wenwei, Mu, Feng, Yin, Ye, Yang, Huanming, Lisby, Michael, Cornall, Richard J., Mulder, Jan, Uhlén, Mathias, Esteban, Miguel A., Li, Yuxiang, Liu, Longqi, Xu, Xun, and Wang, Jian

Published
2022
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6. Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19

Author

Wang, Jun, Kotagiri, Prasanti, Lyons, Paul A., Al-Lamki, Rafia S., Mescia, Federica, Bergamaschi, Laura, Turner, Lorinda, Morgan, Michael D., Calero-Nieto, Fernando J., Bach, Karsten, Mende, Nicole, Wilson, Nicola K., Watts, Emily R., Maxwell, Patrick H., Chinnery, Patrick F., Kingston, Nathalie, Papadia, Sofia, Stirrups, Kathleen E., Walker, Neil, Gupta, Ravindra K., Menon, David K., Allinson, Kieren, Aitken, Sarah J., Toshner, Mark, Weekes, Michael P., Nathan, James A., Walmsley, Sarah R., Ouwehand, Willem H., Kasanicki, Mary, Göttgens, Berthold, Marioni, John C., Smith, Kenneth G.C., Pober, Jordan S., and Bradley, John R.

Published
2022
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7. The impact of hypoxia on B cells in COVID-19

Author

Kotagiri, Prasanti, Mescia, Federica, Hanson, Aimee L., Turner, Lorinda, Bergamaschi, Laura, Peñalver, Ana, Richoz, Nathan, Moore, Stephen D., Ortmann, Brian M., Dunmore, Benjamin J., Morgan, Michael D., Tuong, Zewen Kelvin, Göttgens, Berthold, Toshner, Mark, Hess, Christoph, Maxwell, Patrick. H., Clatworthy, Menna. R., Nathan, James A., Bradley, John R., Lyons, Paul A., Burrows, Natalie, and Smith, Kenneth G.C.

Published
2022
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8. Rolling back human pluripotent stem cells to an eight-cell embryo-like stage

Author

Mazid, Md. Abdul, Ward, Carl, Luo, Zhiwei, Liu, Chuanyu, Li, Yunpan, Lai, Yiwei, Wu, Liang, Li, Jinxiu, Jia, Wenqi, Jiang, Yu, Liu, Hao, Fu, Lixin, Yang, Yueli, Ibañez, David P., Lai, Junjian, Wei, Xiaoyu, An, Juan, Guo, Pengcheng, Yuan, Yue, Deng, Qiuting, Wang, Yang, Liu, Ying, Gao, Fei, Wang, Junwen, Zaman, Shahriar, Qin, Baoming, Wu, Guangming, Maxwell, Patrick H., Xu, Xun, Liu, Longqi, Li, Wenjuan, and Esteban, Miguel A.

Published
2022
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9. Cell transcriptomic atlas of the non-human primate Macaca fascicularis

Author

Han, Lei, Wei, Xiaoyu, Liu, Chuanyu, Volpe, Giacomo, Zhuang, Zhenkun, Zou, Xuanxuan, Wang, Zhifeng, Pan, Taotao, Yuan, Yue, Zhang, Xiao, Fan, Peng, Guo, Pengcheng, Lai, Yiwei, Lei, Ying, Liu, Xingyuan, Yu, Feng, Shangguan, Shuncheng, Lai, Guangyao, Deng, Qiuting, Liu, Ya, Wu, Liang, Shi, Quan, Yu, Hao, Huang, Yunting, Cheng, Mengnan, Xu, Jiangshan, Liu, Yang, Wang, Mingyue, Wang, Chunqing, Zhang, Yuanhang, Xie, Duo, Yang, Yunzhi, Yu, Yeya, Zheng, Huiwen, Wei, Yanrong, Huang, Fubaoqian, Lei, Junjie, Huang, Waidong, Zhu, Zhiyong, Lu, Haorong, Wang, Bo, Wei, Xiaofeng, Chen, Fengzhen, Yang, Tao, Du, Wensi, Chen, Jing, Xu, Shibo, An, Juan, Ward, Carl, Wang, Zongren, Pei, Zhong, Wong, Chi-Wai, Liu, Xiaolei, Zhang, Huafeng, Liu, Mingyuan, Qin, Baoming, Schambach, Axel, Isern, Joan, Feng, Liqiang, Liu, Yan, Guo, Xiangyu, Liu, Zhen, Sun, Qiang, Maxwell, Patrick H., Barker, Nick, Muñoz-Cánoves, Pura, Gu, Ying, Mulder, Jan, Uhlen, Mathias, Tan, Tao, Liu, Shiping, Yang, Huanming, Wang, Jian, Hou, Yong, Xu, Xun, Esteban, Miguel A., and Liu, Longqi

Published
2022
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10. Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

Author

Aggarwal, Dinesh, Warne, Ben, Jahun, Aminu S., Hamilton, William L., Fieldman, Thomas, du Plessis, Louis, Hill, Verity, Blane, Beth, Watkins, Emmeline, Wright, Elizabeth, Hall, Grant, Ludden, Catherine, Myers, Richard, Hosmillo, Myra, Chaudhry, Yasmin, Pinckert, Malte L., Georgana, Iliana, Izuagbe, Rhys, Leek, Danielle, Nsonwu, Olisaeloka, Hughes, Gareth J., Packer, Simon, Page, Andrew J., Metaxaki, Marina, Fuller, Stewart, Weale, Gillian, Holgate, Jon, Brown, Christopher A., Howes, Rob, McFarlane, Duncan, Dougan, Gordon, Pybus, Oliver G., Angelis, Daniela De, Maxwell, Patrick H., Peacock, Sharon J., Weekes, Michael P., Illingworth, Chris, Harrison, Ewan M., Matheson, Nicholas J., and Goodfellow, Ian G.

Published
2022
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11. Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility

Author

Douthwaite, Julie A., Brown, Christopher A., Ferdinand, John R., Sharma, Rahul, Elliott, Jane, Taylor, Molly A., Malintan, Nancy T., Duvoisin, Hannah, Hill, Thomas, Delpuech, Oona, Orton, Alexandra L., Pitt, Haidee, Kuenzi, Fred, Fish, Simon, Nicholls, David J., Cuthbert, Anna, Richards, Ian, Ratcliffe, Giles, Upadhyay, Abhishek, Marklew, Abigail, Hewitt, Craig, Ross-Thriepland, Douglas, Brankin, Christopher, Chodorge, Matthieu, Browne, Gareth, Mander, Palwinder K., DeWildt, Ruud M., Weaver, Shane, Smee, Penny A., van Kempen, Joost, Bartlett, Jon G., Allen, Paula M., Koppe, Emma L., Ashby, Charlotte A., Phipps, Julian D., Mehta, Nalini, Brierley, David J., Tew, David G., Leveridge, Melanie V., Baddeley, Stuart M., Goodfellow, Ian G., Green, Clive, Abell, Chris, Neely, Andy, Waddell, Ian, Rees, Steve, Maxwell, Patrick H., Pangalos, Menelas N., Howes, Rob, and Clark, Roger

Published
2022
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13. Lifespan Extension by Retrotransposons under Conditions of Mild Stress Requires Genes Involved in tRNA Modifications and Nucleotide Metabolism.

Author

Maxwell, Patrick H., Mahmood, Mustafa, Villanueva, Maya, Devine, Kaitlyn, and Avery, Nina

Subjects
*MOBILE genetic elements, *GENE expression, *PROMOTERS (Genetics), *RETROTRANSPOSONS, *PHENOTYPES, *TRANSFER RNA
Abstract

Retrotransposons are mobile DNA elements that are more active with increasing age and exacerbate aging phenotypes in multiple species. We previously reported an unexpected extension of chronological lifespan in the yeast, Saccharomyces paradoxus, due to the presence of Ty1 retrotransposons when cells were aged under conditions of mild stress. In this study, we tested a subset of genes identified by RNA-seq to be differentially expressed in S. paradoxus strains with a high-copy number of Ty1 retrotransposons compared with a strain with no retrotransposons and additional candidate genes for their contribution to lifespan extension when cells were exposed to a moderate dose of hydroxyurea (HU). Deletion of ADE8, NCS2, or TRM9 prevented lifespan extension, while deletion of CDD1, HAC1, or IRE1 partially prevented lifespan extension. Genes overexpressed in high-copy Ty1 strains did not typically have Ty1 insertions in their promoter regions. We found that silencing genomic copies of Ty1 prevented lifespan extension, while expression of Ty1 from a high-copy plasmid extended lifespan in medium with HU or synthetic medium. These results indicate that cells adapt to expression of retrotransposons by changing gene expression in a manner that can better prepare them to remain healthy under mild stress. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

Author

Young, Matthew D., Mitchell, Thomas J., Braga, Felipe A. Vieira, Tran, Maxine G. B., Stewart, Benjamin J., Ferdinand, John R., Collord, Grace, Botting, Rachel A., Popescu, Dorin-Mirel, Loudon, Kevin W., Vento-Tormo, Roser, Stephenson, Emily, Cagan, Alex, Farndon, Sarah J., Del Castillo Velasco-Herrera, Martin, Guzzo, Charlotte, Richoz, Nathan, Mamanova, Lira, Aho, Tevita, Armitage, James N., Riddick, Antony C. P., Mushtaq, Imran, Farrell, Stephen, Rampling, Dyanne, Nicholson, James, Filby, Andrew, Burge, Johanna, Lisgo, Steven, Maxwell, Patrick H., Lindsay, Susan, Warren, Anne Y., Stewart, Grant D., Sebire, Neil, Coleman, Nicholas, Haniffa, Muzlifah, Teichmann, Sarah A., Clatworthy, Menna, and Behjati, Sam

Published
2018

26. Data from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

Author

Ashrafian, Houman, primary, O'Flaherty, Linda, primary, Adam, Julie, primary, Steeples, Violetta, primary, Chung, Yuen-Li, primary, East, Phil, primary, Vanharanta, Sakari, primary, Lehtonen, Heli, primary, Nye, Emma, primary, Hatipoglu, Emine, primary, Miranda, Melroy, primary, Howarth, Kimberley, primary, Shukla, Deepa, primary, Troy, Helen, primary, Griffiths, John, primary, Spencer-Dene, Bradley, primary, Yusuf, Mohammed, primary, Volpi, Emanuela, primary, Maxwell, Patrick H., primary, Stamp, Gordon, primary, Poulsom, Richard, primary, Pugh, Christopher W., primary, Costa, Barbara, primary, Bardella, Chiara, primary, Di Renzo, Maria Flavia, primary, Kotlikoff, Michael I., primary, Launonen, Virpi, primary, Aaltonen, Lauri, primary, El-Bahrawy, Mona, primary, Tomlinson, Ian, primary, and Pollard, Patrick J., primary

Published
2023
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27. Supplementary Figure 1 from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

Author

Ashrafian, Houman, primary, O'Flaherty, Linda, primary, Adam, Julie, primary, Steeples, Violetta, primary, Chung, Yuen-Li, primary, East, Phil, primary, Vanharanta, Sakari, primary, Lehtonen, Heli, primary, Nye, Emma, primary, Hatipoglu, Emine, primary, Miranda, Melroy, primary, Howarth, Kimberley, primary, Shukla, Deepa, primary, Troy, Helen, primary, Griffiths, John, primary, Spencer-Dene, Bradley, primary, Yusuf, Mohammed, primary, Volpi, Emanuela, primary, Maxwell, Patrick H., primary, Stamp, Gordon, primary, Poulsom, Richard, primary, Pugh, Christopher W., primary, Costa, Barbara, primary, Bardella, Chiara, primary, Di Renzo, Maria Flavia, primary, Kotlikoff, Michael I., primary, Launonen, Virpi, primary, Aaltonen, Lauri, primary, El-Bahrawy, Mona, primary, Tomlinson, Ian, primary, and Pollard, Patrick J., primary

Published
2023
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28. Supplementary Methods from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

Author

Ashrafian, Houman, primary, O'Flaherty, Linda, primary, Adam, Julie, primary, Steeples, Violetta, primary, Chung, Yuen-Li, primary, East, Phil, primary, Vanharanta, Sakari, primary, Lehtonen, Heli, primary, Nye, Emma, primary, Hatipoglu, Emine, primary, Miranda, Melroy, primary, Howarth, Kimberley, primary, Shukla, Deepa, primary, Troy, Helen, primary, Griffiths, John, primary, Spencer-Dene, Bradley, primary, Yusuf, Mohammed, primary, Volpi, Emanuela, primary, Maxwell, Patrick H., primary, Stamp, Gordon, primary, Poulsom, Richard, primary, Pugh, Christopher W., primary, Costa, Barbara, primary, Bardella, Chiara, primary, Di Renzo, Maria Flavia, primary, Kotlikoff, Michael I., primary, Launonen, Virpi, primary, Aaltonen, Lauri, primary, El-Bahrawy, Mona, primary, Tomlinson, Ian, primary, and Pollard, Patrick J., primary

Published
2023
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29. Supplementary Table 1 from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

Author

Ashrafian, Houman, primary, O'Flaherty, Linda, primary, Adam, Julie, primary, Steeples, Violetta, primary, Chung, Yuen-Li, primary, East, Phil, primary, Vanharanta, Sakari, primary, Lehtonen, Heli, primary, Nye, Emma, primary, Hatipoglu, Emine, primary, Miranda, Melroy, primary, Howarth, Kimberley, primary, Shukla, Deepa, primary, Troy, Helen, primary, Griffiths, John, primary, Spencer-Dene, Bradley, primary, Yusuf, Mohammed, primary, Volpi, Emanuela, primary, Maxwell, Patrick H., primary, Stamp, Gordon, primary, Poulsom, Richard, primary, Pugh, Christopher W., primary, Costa, Barbara, primary, Bardella, Chiara, primary, Di Renzo, Maria Flavia, primary, Kotlikoff, Michael I., primary, Launonen, Virpi, primary, Aaltonen, Lauri, primary, El-Bahrawy, Mona, primary, Tomlinson, Ian, primary, and Pollard, Patrick J., primary

Published
2023
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30. Supplementary Figure 2 from Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

Author

Ashrafian, Houman, primary, O'Flaherty, Linda, primary, Adam, Julie, primary, Steeples, Violetta, primary, Chung, Yuen-Li, primary, East, Phil, primary, Vanharanta, Sakari, primary, Lehtonen, Heli, primary, Nye, Emma, primary, Hatipoglu, Emine, primary, Miranda, Melroy, primary, Howarth, Kimberley, primary, Shukla, Deepa, primary, Troy, Helen, primary, Griffiths, John, primary, Spencer-Dene, Bradley, primary, Yusuf, Mohammed, primary, Volpi, Emanuela, primary, Maxwell, Patrick H., primary, Stamp, Gordon, primary, Poulsom, Richard, primary, Pugh, Christopher W., primary, Costa, Barbara, primary, Bardella, Chiara, primary, Di Renzo, Maria Flavia, primary, Kotlikoff, Michael I., primary, Launonen, Virpi, primary, Aaltonen, Lauri, primary, El-Bahrawy, Mona, primary, Tomlinson, Ian, primary, and Pollard, Patrick J., primary

Published
2023
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33. Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

Author

Sadiku, Pranvera, Willson, Joseph A., Dickinson, Rebecca S., Murphy, Fiona, Harris, Alison J., Lewis, Amy, Sammut, David, Mirchandani, Ananda S., Ryan, Eilise, Watts, Emily R., Thompson, A.A. Roger, Marriott, Helen M., Dockrell, David H., Taylor, Cormac T., Schneider, Martin, Maxwell, Patrick H., Chilvers, Edwin R., Mazzone, Massimilliano, Moral, Veronica, Pugh, Chris W., Ratcliffe, Peter J., Schofield, Christopher J., Ghesquiere, Bart, Carmeliet, Peter, Whyte, Moira K.B., and Walmsley, Sarah R.

Subjects
Health aspects, Hydroxylases -- Health aspects, Glycogen -- Health aspects, Neutrophils -- Health aspects
Abstract

Introduction Inappropriate or persistent neutrophilic inflammation is implicated in a number of disease states exemplified by acute lung injury responses and chronic obstructive pulmonary disease. There are, to date, no [...], Fully activated innate immune cells are required for effective responses to infection, but their prompt deactivation and removal are essential for limiting tissue damage. Here, we have identified a critical role for the prolyl hydroxylase enzyme Phd2 in maintaining the balance between appropriate, predominantly neutrophil -mediated pathogen clearance and resolution of the innate immune response. We demonstrate that myeloid-specific loss of Phd2 resulted in an exaggerated inflammatory response to Streptococcus pneumonia, with increases in neutrophil motility, functional capacity, and survival. These enhanced neutrophil responses were dependent upon increases in glycolytic flux and glycogen stores. Systemic administration of a HIF-prolyl hydroxylase inhibitor replicated the Phd2-deficient phenotype of delayed inflammation resolution. Together, these data identify Phd2 as the dominant HIF-hydroxylase in neutrophils under normoxic conditions and link intrinsic regulation of glycolysis and glycogen stores to the resolution of neutrophil-mediated inflammatory responses. These results demonstrate the therapeutic potential of targeting metabolic pathways in the treatment of inflammatory disease.

Published
2017
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42. Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

Author

Adam, Julie, Hatipoglu, Emine, O'Flaherty, Linda, Ternette, Nicola, Sahgal, Natasha, Lockstone, Helen, Baban, Dilair, Nye, Emma, Stamp, Gordon W., Wolhuter, Kathryn, Stevens, Marcus, Fischer, Roman, Carmeliet, Peter, Maxwell, Patrick H., Pugh, Chris W., Frizzell, Norma, Soga, Tomoyoshi, Kessler, Benedikt M., El-Bahrawy, Mona, Ratcliffe, Peter J., and Pollard, Patrick J.

Published
2011
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50. Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis

Author

Gale, Daniel P, de Jorge, Elena Goicoechea, Cook, H Terence, Martinez-Barricarte, Rubén, Hadjisavvas, Andreas, McLean, Adam G, Pusey, Charles D, Pierides, Alkis, Kyriacou, Kyriacos, Athanasiou, Yiannis, Voskarides, Konstantinos, Deltas, Constantinos, Palmer, Andrew, Frémeaux-Bacchi, Véronique, de Cordoba, Santiago Rodriguez, Maxwell, Patrick H, and Pickering, Matthew C

Published
2010
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