6,035 results on '"Maxwell, M."'
Search Results
2. Assessment of community awareness and screening of Chagas disease in the Latin american community of Greater New Orleans
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Herrera, Claudia, Bernabe, Kerlly J, DeCuir, James, Dumonteil, Eric, Thompson, Julie M, Avendano, Mariana, Tu, Weihong, Leonhardt, Maxwell M, Northland, Bianka A, Frederick, Jynx, Prieto, Bryn, Paternina-Caicedo, Angel, Ortega, Emma, Fonseca, Maria, Hincapie, Marcela, and Echeverri, Margarita
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- 2023
3. Regulating the proinflammatory response to composite biomaterials by targeting immunometabolism
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Chima V. Maduka, Ashley V. Makela, Anthony Tundo, Evran Ural, Katlin B. Stivers, Maxwell M. Kuhnert, Mohammed Alhaj, Ehsanul Hoque Apu, Nureddin Ashammakhi, Kurt D. Hankenson, Ramani Narayan, Jennifer H. Elisseeff, and Christopher H. Contag
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Hydroxyapatite ,Polylactide ,Immunometabolism ,Inflammation ,Regenerative medicine ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biology (General) ,QH301-705.5 - Abstract
Composite biomaterials comprising polylactide (PLA) and hydroxyapatite (HA) are applied in bone, cartilage and dental regenerative medicine, where HA confers osteoconductive properties. However, after surgical implantation, adverse immune responses to these composites can occur, which have been attributed to size and morphology of HA particles. Approaches to effectively modulate these adverse immune responses have not been described. PLA degradation products have been shown to alter immune cell metabolism (immunometabolism), which drives the inflammatory response. Accordingly, to modulate the inflammatory response to composite biomaterials, inhibitors were incorporated into composites comprised of amorphous PLA (aPLA) and HA (aPLA + HA) to regulate glycolytic flux. Inhibition at specific steps in glycolysis reduced proinflammatory (CD86+CD206-) and increased pro-regenerative (CD206+) immune cell populations around implanted aPLA + HA. Notably, neutrophil and dendritic cell (DC) numbers along with proinflammatory monocyte and macrophage populations were decreased, and Arginase 1 expression among DCs was increased. Targeting immunometabolism to control the proinflammatory response to biomaterial composites, thereby creating a pro-regenerative microenvironment, is a significant advance in tissue engineering where immunomodulation enhances osseointegration and angiogenesis, which could lead to improved bone regeneration.
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- 2024
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4. Modeling observed gender imbalances in academic citation practices
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Stiso, Jennifer, Oudyk, Kendra, Bertolero, Maxwell M., Zhou, Dale, Teich, Erin G., Lydon-Staley, David M., Zurn, Perry, and Bassett, Dani S.
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Computer Science - Digital Libraries ,Quantitative Biology - Neurons and Cognition - Abstract
In multiple academic disciplines, having a perceived gender of `woman' is associated with a lower than expected rate of citations. In some fields, that disparity is driven primarily by the citations of men and is increasing over time despite increasing diversification of the profession. It is likely that complex social interactions and individual ideologies shape these disparities. Computational models of select factors that reproduce empirical observations can help us understand some of the minimal driving forces behind these complex phenomena and therefore aid in their mitigation. Here, we present a simple agent-based model of citation practices within academia, in which academics generate citations based on three factors: their estimate of the collaborative network of the field, how they sample that estimate, and how open they are to learning about their field from other academics. We show that increasing homophily -- or the tendency of people to interact with others more like themselves -- in these three domains is sufficient to reproduce observed biases in citation practices. We find that homophily in sampling an estimate of the field influences total citation rates, and openness to learning from new and unfamiliar authors influences the change in those citations over time. We next model a real-world intervention -- the citation diversity statement -- which has the potential to influence both of these parameters. We determine a parameterization of our model that matches the citation practices of academics who use the citation diversity statement. This parameterization paired with an openness to learning from many new authors can result in citation practices that are equitable and stable over time. Ultimately, our work underscores the importance of homophily in shaping citation practices and provides evidence that specific actions may mitigate biased citation practices in academia.
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- 2022
5. Clinical Characteristics and Outcomes of COVID-19 in Pediatric and Early Adolescent and Young Adult Hematopoietic Stem Cell Transplant Recipients: A Cohort Study
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Bhatt, Neel S, Sharma, Akshay, St Martin, Andrew, Abid, Muhammad Bilal, Brown, Valerie I, Diaz Perez, Miguel Angel, Frangoul, Haydar, Gadalla, Shahinaz M, Herr, Megan M, Krem, Maxwell M, Lazarus, Hillard M, Martens, Michael J, Mehta, Parinda A, Nishihori, Taiga, Prestidge, Tim, Pulsipher, Michael A, Rangarajan, Hemalatha G, Williams, Kirsten M, Winestone, Lena E, Yin, Dwight E, Riches, Marcie L, Dandoy, Christopher E, and Auletta, Jeffery J
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Stem Cell Research - Nonembryonic - Human ,Stem Cell Research ,Pediatric Research Initiative ,Pediatric ,Transplantation ,Cancer ,Clinical Research ,Regenerative Medicine ,Prevention ,Good Health and Well Being ,Adolescent ,COVID-19 ,COVID-19 Testing ,Child ,Cohort Studies ,Hematopoietic Stem Cell Transplantation ,Humans ,Oxygen ,Young Adult ,Covid-19 ,Early adolescent and young adult ,Hematopoietic stem cell ,Clinical Sciences ,Immunology ,Cardiovascular medicine and haematology - Abstract
Adult hematopoietic stem cell transplantation (HSCT) recipients are at a high risk of adverse outcomes after COVID-19. Although children have had better outcomes after COVID-19 compared to adults, data on risk factors and outcomes of COVID-19 among pediatric HSCT recipients are lacking. We describe outcomes of HSCT recipients who were ≤21 years of age at COVID-19 diagnosis and were reported to the Center for International Blood and Marrow Transplant Research between March 27, 2020, and May 7, 2021. The primary outcome was overall survival after COVID-19 diagnosis. We determined risk factors of COVID-19 as a secondary outcome in a subset of allogeneic HSCT recipients. A total of 167 pediatric HSCT recipients (135 allogeneic; 32 autologous HSCT recipients) were included. Median time from HSCT to COVID-19 was 15 months (interquartile range [IQR] 7-45) for allogeneic HSCT recipients and 16 months (IQR 6-59) for autologous HSCT recipients. Median follow-up from COVID-19 diagnosis was 53 days (range 1-270) and 37 days (1-179) for allogeneic and autologous HSCT recipients, respectively. Although COVID-19 was mild in 87% (n = 146/167), 10% (n = 16/167) of patients required supplemental oxygen or mechanical ventilation. The 45-day overall survival was 95% (95% confidence interval [CI], 90-99) and 90% (74-99) for allogeneic and autologous HSCT recipients, respectively. Cox regression analysis showed that patients with a hematopoietic cell transplant comorbidity index (HCT-CI) score of 1-2 were more likely to be diagnosed with COVID-19 (hazard ratio 1.95; 95% CI, 1.03-3.69, P = .042) compared to those with an HCT-CI of 0. Pediatric and early adolescent and young adult HSCT recipients with pre-HSCT comorbidities were more likely to be diagnosed with COVID-19. Overall mortality, albeit higher than the reported general population estimates, was lower when compared with previously published data focusing on adult HSCT recipients.
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- 2022
6. The Paradox of Leading amidst Uncertainty: Maintaining Balance on an Unstable Beam
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Yurkofsky, Maxwell M. and Peurach, Donald J.
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Purpose: This paper proposes a new conception of school systems arising out of the collision of three forces--(1) a longstanding press to rationalize the technical work of schools in the service of educational excellence; (2) a growing democratic press to equitably engage community members in the process of defining educational excellence; which together are (3) heightening legacy uncertainties that pervade educational organizations. It then draws on paradox theory to explore how leaders might navigate the growing uncertainties that are central to the work of organizing for excellence and equity. Design/methodology/approach: Integrating scholarship related to organizational institutionalism, paradox theory, learning sciences, social justice leadership and educational system building, this paper examines the changing organization of schools, the growing uncertainty facing educators and the implications for leaders and preparation programs. Findings: This paper introduces two perspectives on how to navigate the growing uncertainty facing educators and educational leaders--one that centers on mitigating uncertainty, the other that prioritizes leveraging uncertainty. Both perspectives have affordances and limitations when considering the twin goals of educational excellence and equitable involvement in decision-making, and leaders should thus view uncertainty as a paradox--an interdependent, persistent, contradiction--that can never be fully resolved, but can be managed. A paradox perspective makes visible the complex work of effectively moving between mitigating and leveraging uncertainty, especially in a field where the latter garners more support and legitimacy. Originality/value: This paper synthesizes recent educational and organizational scholarship to develop a new conception of educational organizations and a corresponding approach to educational leadership capable of navigating the growing complexity and uncertainty that pervades school systems.
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- 2023
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7. Donor types and outcomes of transplantation in myelofibrosis: a CIBMTR study
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Jain, Tania, Estrada-Merly, Noel, Salas, M. Queralt, Kim, Soyoung, DeVos, Jakob, Chen, Min, Fang, Xi, Kumar, Rajat, Andrade-Campos, Marcio, Elmariah, Hany, Agrawal, Vaibhav, Aljurf, Mahmoud, Bacher, Ulrike, Badar, Talha, Badawy, Sherif M., Ballen, Karen, Beitinjaneh, Amer, Bhatt, Vijaya Raj, Bredeson, Christopher, DeFilipp, Zachariah, Dholaria, Bhagirathbhai, Farhadfar, Nosha, Farhan, Shatha, Gandhi, Arpita P., Ganguly, Siddhartha, Gergis, Usama, Grunwald, Michael R., Hamad, Nada, Hamilton, Betty K., Inamoto, Yoshihiro, Iqbal, Madiha, Jamy, Omer, Juckett, Mark, Kharfan-Dabaja, Mohamed A., Krem, Maxwell M., Lad, Deepesh P., Liesveld, Jane, Al Malki, Monzr M., Malone, Adriana K., Murthy, Hemant S., Ortí, Guillermo, Patel, Sagar S., Pawarode, Attaphol, Perales, Miguel-Angel, van der Poel, Marjolein, Ringden, Olle, Rizzieri, David A., Rovó, Alicia, Savani, Bipin N., Savoie, Mary Lynn, Seo, Sachiko, Solh, Melhem, Ustun, Celalettin, Verdonck, Leo F., Wingard, John R., Wirk, Baldeep, Bejanyan, Nelli, Jones, Richard J., Nishihori, Taiga, Oran, Betul, Nakamura, Ryotaro, Scott, Bart, Saber, Wael, and Gupta, Vikas
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- 2024
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8. LipIDens: simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins
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T. Bertie Ansell, Wanling Song, Claire E. Coupland, Loic Carrique, Robin A. Corey, Anna L. Duncan, C. Keith Cassidy, Maxwell M. G. Geurts, Tim Rasmussen, Andrew B. Ward, Christian Siebold, Phillip J. Stansfeld, and Mark S. P. Sansom
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Science - Abstract
Abstract Cryo-electron microscopy (cryo-EM) enables the determination of membrane protein structures in native-like environments. Characterising how membrane proteins interact with the surrounding membrane lipid environment is assisted by resolution of lipid-like densities visible in cryo-EM maps. Nevertheless, establishing the molecular identity of putative lipid and/or detergent densities remains challenging. Here we present LipIDens, a pipeline for molecular dynamics (MD) simulation-assisted interpretation of lipid and lipid-like densities in cryo-EM structures. The pipeline integrates the implementation and analysis of multi-scale MD simulations for identification, ranking and refinement of lipid binding poses which superpose onto cryo-EM map densities. Thus, LipIDens enables direct integration of experimental and computational structural approaches to facilitate the interpretation of lipid-like cryo-EM densities and to reveal the molecular identities of protein-lipid interactions within a bilayer environment. We demonstrate this by application of our open-source LipIDens code to ten diverse membrane protein structures which exhibit lipid-like densities.
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- 2023
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9. Hospital Course and Complications of Subaxial Cervical Trauma Patients With Tetraplegia or Paraplegia: A Case Series and Literature Review
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Scott, Maxwell M., Patel, Dil V., Lucasti, Christopher, Vallee, Emily K., Clark, Lindsey D., and Kowalski, Joseph M.
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- 2024
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10. Regulating the proinflammatory response to composite biomaterials by targeting immunometabolism
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Maduka, Chima V., Makela, Ashley V., Tundo, Anthony, Ural, Evran, Stivers, Katlin B., Kuhnert, Maxwell M., Alhaj, Mohammed, Hoque Apu, Ehsanul, Ashammakhi, Nureddin, Hankenson, Kurt D., Narayan, Ramani, Elisseeff, Jennifer H., and Contag, Christopher H.
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- 2024
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11. LipIDens: simulation assisted interpretation of lipid densities in cryo-EM structures of membrane proteins
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Ansell, T. Bertie, Song, Wanling, Coupland, Claire E., Carrique, Loic, Corey, Robin A., Duncan, Anna L., Cassidy, C. Keith, Geurts, Maxwell M. G., Rasmussen, Tim, Ward, Andrew B., Siebold, Christian, Stansfeld, Phillip J., and Sansom, Mark S. P.
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- 2023
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12. The 27 Facial Sutures: Timing and Clinical Consequences of Closure
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Wang, Maxwell M, Haveles, Christos S, Zukotynski, Brian K, Reid, Russell R, and Lee, Justine C
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Biomedical and Clinical Sciences ,Dentistry ,Pediatric Research Initiative ,Pediatric ,Rare Diseases ,Congenital Structural Anomalies ,Dental/Oral and Craniofacial Disease ,Good Health and Well Being ,Cranial Sutures ,Craniosynostoses ,Facial Bones ,Humans ,Clinical Sciences ,Surgery ,Clinical sciences - Abstract
SummaryFacial sutures contribute significantly to postnatal facial development, but their potential role in craniofacial disease is understudied. Since interest in their development and physiology peaked in the mid-twentieth century, facial sutures have not garnered nearly the same clinical research interest as calvarial sutures or cranial base endochondral articulations. In addition to reinforcing the complex structure of the facial skeleton, facial sutures absorb mechanical stress and generally remain patent into and beyond adolescence, as they mediate growth and refine the shape of facial bones. However, premature closure of these sites of postnatal osteogenesis leads to disrupted growth vectors and consequent dysmorphologies. Although abnormality in individual sutures results in isolated facial deformities, we posit that generalized abnormality across multiple sutures may be involved in complex craniofacial conditions such as syndromic craniosynostosis. In this work, the authors comprehensively review 27 key facial sutures, including physiologic maturation and closure, contributions to postnatal facial development, and clinical consequences of premature closure.
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- 2022
13. Training Topology With Graph Neural Cellular Automata.
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Daniel Dwyer and Maxwell M. Omwenga
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- 2023
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14. Asymptotically Optimal Finite-Dimensional Approximations for Linear Filtering with Infinite-Dimensional Measurements.
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Maxwell M. Varley, Timothy L. Molloy, and Girish N. Nair
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- 2023
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15. Zinc, carbon, and oxygen isotopic variations associated with the Marinoan deglaciation
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Thiemens, Maxwell M., Shaheen, Robina, Gerritzen, Carina T., Gyollai, Ildiko, Chong, Kenneth, Popp, Friedrich, Koeberl, Christian, Thiemens, Mark H., and Moynier, Frédéric
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- 2023
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16. Terahertz optical Hall effect determination of carrier concentrations in component layers within low bandgap tin–lead halide perovskite photovoltaics and device simulation
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Mainali, Madan K., Uprety, Prakash, Song, Zhaoning, Wang, Changlei, Subedi, Indra, Subedi, Biwas, Ghimire, Kiran, Junda, Maxwell M., Yan, Yanfa, and Podraza, Nikolas J.
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- 2024
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17. An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis
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Jimenez Jimenez, Antonio M, De Lima, Marcos, Komanduri, Krishna V, Wang, Trent P, Zhang, Mei-Jie, Chen, Karen, Abdel-Azim, Hisham, Abid, Muhammad Bilal, Aljurf, Mahmoud, Alkhateeb, Hassan, Assal, Amer, Bacher, Ulrike, Baron, Frédéric, Battiwalla, Minoo, Beitinjaneh, Amer, Bejanyan, Nelli, Bhatt, Vijaya Raj, Byrne, Michael, Cahn, Jean-Yves, Cairo, Mitchell, Castillo, Paul, Copelan, Edward, DeFilipp, Zachariah, Perez, Miguel Angel Diaz, Elsawy, Mahmoud, Gale, Robert Peter, George, Biju, Grunwald, Michael R, Hildebrandt, Gerhard C, Hogan, William J, Kanakry, Christopher G, Kansagra, Ankit, Kharfan-Dabaja, Mohamed A, Khera, Nandita, Krem, Maxwell M, Lazaryan, Aleksandr, Maakaron, Joseph, Martino, Rodrigo, McGuirk, Joseph, Michelis, Fotios V, Milone, Giuseppe, Mishra, Asmita, Murthy, Hemant S, Mussetti, Alberto, Nathan, Sunita, Nishihori, Taiga, Olsson, Richard F, Palmisiano, Neil, Patel, Sagar, Saad, Ayman, Seo, Sachiko, Sharma, Akshay, Solh, Melhem, Verdonck, Leo F, Wirk, Baldeep, Yared, Jean A, Litzow, Mark, Kebriaei, Partow, Hourigan, Christopher S, Saber, Wael, and Weisdorf, Daniel
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Oncology and Carcinogenesis ,Hematology ,Genetics ,Transplantation ,Pediatric Research Initiative ,Childhood Leukemia ,Stem Cell Research ,Cancer ,Clinical Research ,Pediatric Cancer ,Rare Diseases ,Pediatric ,Stem Cell Research - Nonembryonic - Human ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,Good Health and Well Being ,Hematopoietic Stem Cell Transplantation ,Humans ,Leukemia ,Myeloid ,Acute ,Retrospective Studies ,Risk Assessment ,Transplantation Conditioning ,Transplantation ,Homologous ,Clinical Sciences ,Immunology ,Cardiovascular medicine and haematology ,Oncology and carcinogenesis - Abstract
Cytogenetic and molecular abnormalities are known to influence post-transplant outcomes in acute myeloid leukemia (AML) but data assessing the prognostic value of combined genetic models in the HCT setting are limited. We developed an adapted European LeukemiaNet (aELN) risk classification based on available genetic data reported to the Center for International Blood and Marrow Transplant Research, to predict post-transplant outcomes in 2289 adult AML patients transplanted in first remission, between 2013 and 2017. Patients were stratified according to aELN into three groups: favorable (Fav, N = 181), intermediate (IM, N = 1185), and adverse (Adv, N = 923). Univariate analysis demonstrated significant differences in 2-year overall survival (OS) (Fav: 67.7%, IM: 64.9% and Adv: 53.9%; p
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- 2021
18. Facial Suture Pathology in Syndromic Craniosynostosis
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Wang, Maxwell M, Haveles, Christos S, Zukotynski, Brian K, Reid, Russell R, and Lee, Justine C
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Biomedical and Clinical Sciences ,Dentistry ,Rare Diseases ,Pediatric Research Initiative ,Pediatric ,Dental/Oral and Craniofacial Disease ,Congenital Structural Anomalies ,Animals ,Cranial Sutures ,Craniosynostoses ,Humans ,Mice ,Sutures ,Syndrome ,Tomography ,X-Ray Computed ,mice ,humans ,osteogenesis ,osteology ,MEDLINE ,syndrome ,craniosynostosis ,skull base ,models ,sutures ,craniofacial ,plastic surgery ,syndromic craniosynostosis ,facial sutures ,dysmorphologies ,hypertelorism ,exorbitism ,synostosis ,premature fusion ,spheno-occipital synchondrosis ,ossification ,craniofacial malformations ,Le Fort III ,reconstructive surgery ,suturectomy ,pharmacologic FGFR inhibitors ,Clinical Sciences ,Surgery ,Clinical sciences - Abstract
BackgroundFacial deformities in syndromic craniosynostosis are not only functionally, psychosocially, and aesthetically impairing but also notoriously challenging to reconstruct. Whether facial suture synostosis plays a significant role in the pathogenesis of these deformities is inadequately studied in human patients.MethodsThe MEDLINE database was queried using a methodologically generated search term inventory. Article inclusion was adjudicated by 2 authors after independent review. Articles provided insight into facial suture involvement in either syndromic craniosynostosis patients or animal models of disease.ResultsComprehensive review yielded 19 relevant articles meeting inclusion criteria. Mid-20th century craniofacial biologists characterized how patent facial sutures are essential for normal postnatal facial development. They also posited that premature ossification disrupts growth vectors, causing significant dysmorphologies. Recently, facial suture synostosis was found to cause midfacial deformities independent of cranial base pathology in mouse models of syndromic craniosynostosis. Few recent studies have begun exploring facial suture involvement in patients, and although they have paved the way for future research, they bear significant limitations.ConclusionsThe hypothesis that facial suture synostosis acts in conjunction with cranial base pathology to produce the prominent, multifocal facial deformities in syndromic craniosynostosis may fundamentally alter surgical management and warrants further investigation. Methodically evaluating the literature, this review synthesizes all basic science and human clinical research thus far on the role of facial sutures in syndromic craniosynostosis and elucidates important topics for future research. We ultimately identify the need for rigorous imaging studies that longitudinally evaluate facial osteology across patients with various craniosynostosis syndromes.
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- 2021
19. The paradox of leading amidst uncertainty: maintaining balance on an unstable beam
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Yurkofsky, Maxwell M. and Peurach, Donald J.
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- 2023
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20. Return to Work Among Young Adult Survivors of Allogeneic Hematopoietic Cell Transplantation in the United States
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Bhatt, Neel S, Brazauskas, Ruta, Salit, Rachel B, Syrjala, Karen, Bo-Subait, Stephanie, Tecca, Heather, Badawy, Sherif M, Baker, K Scott, Beitinjaneh, Amer, Bejanyan, Nelli, Byrne, Michael, Dias, Ajoy, Farhadfar, Nosha, Freytes, César O, Ganguly, Siddhartha, Hashmi, Shahrukh, Hayashi, Robert J, Hong, Sanghee, Inamoto, Yoshihiro, Jamani, Kareem, Kasow, Kimberly A, Khera, Nandita, Krem, Maxwell M, Lazarus, Hillard M, Lee, Catherine J, Lee, Stephanie, Majhail, Navneet S, Malone, Adriana K, Marks, David I, Mau, Lih-Wen, Mayo, Samantha J, Muffly, Lori S, Nathan, Sunita, Nishihori, Taiga, Page, Kristin M, Preussler, Jaime, Rangarajan, Hemalatha G, Rotz, Seth J, Salooja, Nina, Savani, Bipin N, Schears, Raquel, Schechter-Finkelstein, Tal, Schiller, Gary, Shah, Ami J, Sharma, Akshay, Wang, Trent, Wirk, Baldeep, Battiwalla, Minoo, Schoemans, Hélène, Hamilton, Betty, Buchbinder, David, Phelan, Rachel, and Shaw, Bronwen
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Biomedical and Clinical Sciences ,Clinical Sciences ,Cancer ,Transplantation ,Clinical Research ,Rehabilitation ,Behavioral and Social Science ,Quality Education ,Female ,Hematopoietic Stem Cell Transplantation ,Humans ,Neoplasm Recurrence ,Local ,Return to Work ,Survivors ,Transplantation ,Homologous ,United States ,Young Adult ,Hematopoietic cell transplantation ,Return to work ,Quality of life ,Young adult ,Immunology ,Cardiovascular medicine and haematology - Abstract
Young adult (YA) survivors of allogeneic hematopoietic cell transplantation (HCT) are at risk for late psychosocial challenges, including the inability to return to work post-HCT. Work-related outcomes in this population remain understudied, however. We conducted this study to assess the post-HCT work status of survivors of allogeneic HCT who underwent HCT as YAs and to analyze the patient-, disease-, and HCT-related factors associated with their work status at 1 year post-HCT. Using Center for International Blood and Marrow Transplant Research data, we evaluated the post-HCT work status (full-time, part-time work, unemployed, or medical disability) of 1365 YA HCT survivors who underwent HCT between 2008 and 2015. Percentages of work status categories were reported at 4 time points: 6 months, 1 year, 2 years, and 3 years post-HCT. Percentages of post-HCT work status categories at the 1-year time point were also described in relation to survivors' pre-HCT work status categories. Factors associated with 1-year post-HCT work status (full-time or part-time work) were examined using logistic regression. From 6 months to 3 years post-HCT, the percentage of survivors working full-time increased from 18.3% to 50.7% and the percentage working part-time increased from 6.9% to 10.5%. Of patients in full-time work pre-HCT, 50% were unemployed or on medical disability at 1 year post-HCT. Female sex (odds ratio [OR], 0.55; 95% confidence interval [CI], 0.40 to 0.77), HCT Comorbidity Index score ≥3 (OR, 0.57; 95% CI, 0.39 to 0.82), pre-HCT unemployment (OR, 0.37; 95% CI, 0.24 to 0.56), medical disability (OR, 0.44; 95% CI, 0.28 to 0.70), development of grade III-IV acute graft-versus-host disease (OR, 0.52; 95% CI, 0.34 to 0.80), and relapse within 1 year post-HCT (OR, 0.34; 95% CI, 0.21 to 0.56) were associated with a lower likelihood of employment at 1 year post-HCT. Compared with myeloablative conditioning (MAC) with total body irradiation (TBI), MAC without TBI (OR, 1.71; 95% CI, 1.16 to 2.53) was associated with a greater likelihood of employment at 1 year post-HCT. Graduate school-level education (OR, 2.47; 95% CI, 1.49 to 4.10) was also associated with a greater likelihood of employment at 1 year post-HCT. Although the work status among YA HCT survivors continued to improve over time, a substantial subset became or remained unemployed or on medical disability. These findings underscore the need for effective interventions to support return to work in this population.
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- 2021
21. Incidence and impact of community respiratory viral infections in post‐transplant cyclophosphamide‐based graft‐versus‐host disease prophylaxis and haploidentical stem cell transplantation
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Mulroney, Carolyn M, Abid, Muhammad Bilal, Bashey, Asad, Chemaly, Roy F, Ciurea, Stefan O, Chen, Min, Dandoy, Christopher E, Perez, Miguel A Diaz, Friend, Brian D, Fuchs, Ephraim, Ganguly, Siddhartha, Goldsmith, Scott R, Kanakry, Christopher G, Kim, Soyoung, Komanduri, Krishna V, Krem, Maxwell M, Lazarus, Hillard M, Ljungman, Per, Maziarz, Richard, Nishihori, Taiga, Patel, Sagar S, Perales, Miguel‐Angel, Romee, Rizwan, Singh, Anurag K, Wingard, John Reid, Yared, Jean, Riches, Marcie, and Taplitz, Randy
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Prevention ,Transplantation ,Lung ,Stem Cell Research - Nonembryonic - Human ,Stem Cell Research ,Hematology ,Rare Diseases ,Organ Transplantation ,Orphan Drug ,Cancer ,Infection ,Good Health and Well Being ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Child ,Child ,Preschool ,Community-Acquired Infections ,Cyclophosphamide ,Female ,Graft vs Host Disease ,HLA Antigens ,Hematopoietic Stem Cell Transplantation ,Humans ,Immunosuppressive Agents ,Incidence ,Kaplan-Meier Estimate ,Leukemia ,Living Donors ,Male ,Middle Aged ,Myelodysplastic Syndromes ,Proportional Hazards Models ,Respiratory Tract Infections ,Retrospective Studies ,Siblings ,Transplantation ,Haploidentical ,Virus Diseases ,Young Adult ,Respiratory viral infection ,Post Transplant Cyclophosphamide ,Allogeneic transplant ,Cardiorespiratory Medicine and Haematology ,Immunology - Abstract
Community respiratory viral infections (CRVIs) are associated with pulmonary function impairment, alloimmune lung syndromes and inferior survival in human leucocyte antigen (HLA)-matched allogeneic haematopoietic stem cell transplant (HCT) recipients. Although the incidence of viral infections in HLA-haploidentical HCT recipients who receive post-transplant cyclophosphamide (PTCy)-based graft-versus-host disease (GVHD) prophylaxis is reportedly increased, there are insufficient data describing the incidence of CRVIs and the impact of donor source and PTCy on transplant outcomes. Analysing patients receiving their first HCT between 2012 and 2017 for acute myeloid leukaemia, acute lymphoblastic leukaemia and myelodysplastic syndromes, we describe comparative outcomes between matched sibling transplants receiving either calcineurin-based GVHD prophylaxis (SibCNI, N = 1605) or PTCy (SibCy, N = 403), and related haploidentical transplants receiving PTCy (HaploCy, N = 757). The incidence of CRVIs was higher for patients receiving PTCy, regardless of donor type. Patients in the HaploCy cohort who developed a CRVI by day +180 had both a higher risk of treatment-related mortality [hazard ratio (HR) 2⋅14, 99% confidence interval (CI) 1⋅13-4⋅07; P = 0⋅002] and inferior 2-year overall survival (HR 1⋅65, 99% CI 1⋅11-2⋅43; P = 0⋅001) compared to SibCNI with no CRVI. This finding justifies further research into long-term antiviral immune recovery, as well as development of preventive and treatment strategies to improve long-term outcomes in such patients.
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- 2021
22. Postoperative Admission of Adult Craniotomy Patients to the Neuroscience Ward Reduces Length of Stay and Cost
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Sun, Matthew Z, Babayan, Diana, Chen, Jia-Shu, Wang, Maxwell M, Naik, Priyanka K, Reitz, Kara, Li, Jingyi Jessica, Pouratian, Nader, and Kim, Won
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Neurosciences ,Health Services ,Clinical Research ,Adult ,Craniotomy ,Elective Surgical Procedures ,Hospitals ,Humans ,Length of Stay ,Retrospective Studies ,Craniotomy postop ,Neuroscience ward ,Length of stay ,Admission cost ,Clinical outcome ,Clinical Sciences ,Neurology & Neurosurgery - Abstract
BackgroundThe neurointensive care unit (NICU) has traditionally been the default recovery unit after elective craniotomies.ObjectiveTo assess whether admitting adult patients without significant comorbidities to the neuroscience ward (NW) instead of NICU for recovery resulted in similar clinical outcome while reducing length of stay (LOS) and hospitalization cost.MethodsWe retrospectively analyzed the clinical and cost data of adult patients undergoing supratentorial craniotomy at a university hospital within a 5-yr period who had a LOS less than 7 d. We compared those admitted to the NICU for 1 night of recovery versus those directly admitted to the NW.ResultsThe NICU and NW groups included 340 and 209 patients, respectively, and were comparable in terms of age, ethnicity, overall health, and expected LOS. NW admissions had shorter LOS (3.046 vs 3.586 d, P
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- 2021
23. Performance status, comorbidities, and cycles of methotrexate exert the greatest influence on outcomes of primary and secondary CNS lymphomas: the Lexington experience
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Curry, Lauren D., Munker, Reinhold, Li, Ning, Yan, Donglin, Pryor, Paul, Nozad, Sahar, Keller, Patrick, Monohan, Gregory P., Iragavarapu, Chaitanya, and Krem, Maxwell M.
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- 2023
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24. Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming
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Chima V. Maduka, Mohammed Alhaj, Evran Ural, Oluwatosin M. Habeeb, Maxwell M. Kuhnert, Kylie Smith, Ashley V. Makela, Hunter Pope, Shoue Chen, Jeremy M. Hix, Christiane L. Mallett, Seock‐Jin Chung, Maxwell Hakun, Anthony Tundo, Kurt R. Zinn, Kurt D. Hankenson, Stuart B. Goodman, Ramani Narayan, and Christopher H. Contag
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biocompatibility ,immune cells ,metabolic reprogramming ,polylactide ,tissue regeneration ,Science - Abstract
Abstract Polylactide (PLA) is the most widely utilized biopolymer in medicine. However, chronic inflammation and excessive fibrosis resulting from its degradation remain significant obstacles to extended clinical use. Immune cell activation has been correlated to the acidity of breakdown products, yet methods to neutralize the pH have not significantly reduced adverse responses. Using a bioenergetic model, delayed cellular changes were observed that are not apparent in the short‐term. Amorphous and semi‐crystalline PLA degradation products, including monomeric l‐lactic acid, mechanistically remodel metabolism in cells leading to a reactive immune microenvironment characterized by elevated proinflammatory cytokines. Selective inhibition of metabolic reprogramming and altered bioenergetics both reduce these undesirable high cytokine levels and stimulate anti‐inflammatory signals. The results present a new biocompatibility paradigm by identifying metabolism as a target for immunomodulation to increase tolerance to biomaterials, ensuring safe clinical application of PLA‐based implants for soft‐ and hard‐tissue regeneration, and advancing nanomedicine and drug delivery.
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- 2023
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25. Allogeneic hematopoietic cell transplantation for blastic plasmacytoid dendritic cell neoplasm: a CIBMTR analysis
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Murthy, Hemant S., Zhang, Mei-Jie, Chen, Karen, Ahmed, Sairah, Deotare, Uday, Ganguly, Siddhartha, Kansagra, Ankit, Michelis, Fotios V., Nishihori, Taiga, Patnaik, Mrinal, Abid, Muhammad Bilal, Aljurf, Mahmoud, Arai, Yasuyuki, Bacher, Ulrike, Badar, Talha, Badawy, Sherif M., Ballen, Karen, Battiwalla, Minoo, Beitinjaneh, Amer, Bejanyan, Nelli, Bhatt, Vijaya Raj, Brown, Valerie I., Martino, Rodrigo, Cahn, Jean-Yves, Castillo, Paul, Cerny, Jan, Chhabra, Saurabh, Copelan, Edward, Daly, Andrew, Dholaria, Bhagirathbhai, Diaz Perez, Miguel Angel, Freytes, César O., Grunwald, Michael R., Hashmi, Shahrukh, Hildebrandt, Gerhard C., Jamy, Omer, Joseph, Jacinth, Kanakry, Christopher G., Khera, Nandita, Krem, Maxwell M., Kuwatsuka, Yachiyo, Lazarus, Hillard M., Lekakis, Lazaros J., Liu, Hongtao, Modi, Dipenkumar, Munshi, Pashna N., Mussetti, Alberto, Palmisiano, Neil, Patel, Sagar S., Rizzieri, David A., Seo, Sachiko, Shah, Mithun Vinod, Sharma, Akshay, Sohl, Melhm, Solomon, Scott R., Ulrickson, Matthew, Ustun, Celalettin, van der Poel, Marjolein, Verdonck, Leo F., Wagner, John L., Wang, Trent, Wirk, Baldeep, Zeidan, Amer, Litzow, Mark, Kebriaei, Partow, Hourigan, Christopher S., Weisdorf, Daniel J., Saber, Wael, and Kharfan-Dabaja, Mohamed A.
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- 2023
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26. Glycolytic reprogramming underlies immune cell activation by polyethylene wear particles
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Maduka, Chima V., Habeeb, Oluwatosin M., Kuhnert, Maxwell M., Hakun, Maxwell, Goodman, Stuart B., and Contag, Christopher H.
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- 2023
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27. Characterising the economic Proterozoic Glyde Package of the greater McArthur Basin, northern Australia
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Subarkah, Darwinaji, Collins, Alan S., Farkaš, Juraj, Blades, Morgan L., Gilbert, Sarah E., Jarrett, Amber J.M., Bullen, Maxwell M., and Giuliano, William
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- 2023
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28. Diagnostic value of molecular testing in sonographically suspicious thyroid nodules
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Wang, Maxwell M, Beckett, Katrina, Douek, Michael, Masamed, Rinat, Patel, Maitraya, Tseng, Chi-Hong, Yeh, Michael W, Leung, Angela M, and Livhits, Masha J
- Subjects
Biomedical Imaging ,Clinical Trials and Supportive Activities ,Clinical Research ,Prevention ,molecular testing ,ultrasound ,ATA ,ACR TI-RADS ,thyroid ,nodule ,molecular testing - Abstract
ObjectiveMolecular testing can refine the diagnosis for the 20% of thyroid fine-needle aspiration biopsies that have indeterminate cytology. We assessed the diagnostic accuracy of molecular testing based on ultrasound risk classification.MethodsThis retrospective cohort study analyzed all thyroid nodules with indeterminate cytology at an academic US medical center (2012-2016). All indeterminate nodules underwent reflexive molecular testing with the Afirma Gene Expression Classifier (GEC). Radiologists performed blinded reviews to categorize each nodule according to the American Thyroid Association (ATA) ultrasound classification and the American College of Radiology Thyroid Imaging, Reporting and Data System. GEC results and diagnostic performance were compared across ultrasound risk categories.ResultsOf 297 nodules, histopathology confirmed malignancy in 65 (22%). Nodules by ATA classification were 8% high suspicion, 44% intermediate, and 48% low/very low suspicion. A suspicious GEC result was more likely in ATA high-suspicion nodules (81%) than in nodules of all other ATA categories (57%; P = .04). The positive predictive value (PPV) of GEC remained consistent across ultrasound categories (ATA high suspicion, 64% vs all other ATA categories, 48%; P = .39). The ATA high-suspicion category had higher specificity than a suspicious GEC result (93% vs 51%; P
- Published
- 2020
29. Kalman Filtering for Discrete-Time Linear Systems with Infinite-Dimensional Observations.
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Maxwell M. Varley, Timothy L. Molloy, and Girish N. Nair
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- 2022
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30. Elevated oxidative phosphorylation is critical for immune cell activation by polyethylene wear particles
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Maduka, Chima V., Kuhnert, Maxwell M., Habeeb, Oluwatosin M., Tundo, Anthony, Makela, Ashley V., Goodman, Stuart B., and Contag, Christopher H.
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- 2023
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31. Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa
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Michelle S. Kim, Daphne Naidoo, Ujani Hazra, Melanie H. Quiver, Wenlong C. Chen, Corinne N. Simonti, Paidamoyo Kachambwa, Maxine Harlemon, Ilir Agalliu, Shakuntala Baichoo, Pedro Fernandez, Ann W. Hsing, Mohamed Jalloh, Serigne M. Gueye, Lamine Niang, Halimatou Diop, Medina Ndoye, Nana Yaa Snyper, Ben Adusei, James E. Mensah, Afua O. D. Abrahams, Richard Biritwum, Andrew A. Adjei, Akindele O. Adebiyi, Olayiwola Shittu, Olufemi Ogunbiyi, Sikiru Adebayo, Oseremen I. Aisuodionoe-Shadrach, Maxwell M. Nwegbu, Hafees O. Ajibola, Olabode P. Oluwole, Mustapha A. Jamda, Elvira Singh, Audrey Pentz, Maureen Joffe, Burcu F. Darst, David V. Conti, Christopher A. Haiman, Petrus V. Spies, André van der Merwe, Thomas E. Rohan, Judith Jacobson, Alfred I. Neugut, Jo McBride, Caroline Andrews, Lindsay N. Petersen, Timothy R. Rebbeck, and Joseph Lachance
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Africa ,Health disparities ,Genomic medicine ,Polygenic risk scores ,Population genetics ,Prostate cancer ,Biology (General) ,QH301-705.5 ,Genetics ,QH426-470 - Abstract
Abstract Background Genome-wide association studies do not always replicate well across populations, limiting the generalizability of polygenic risk scores (PRS). Despite higher incidence and mortality rates of prostate cancer in men of African descent, much of what is known about cancer genetics comes from populations of European descent. To understand how well genetic predictions perform in different populations, we evaluated test characteristics of PRS from three previous studies using data from the UK Biobank and a novel dataset of 1298 prostate cancer cases and 1333 controls from Ghana, Nigeria, Senegal, and South Africa. Results Allele frequency differences cause predicted risks of prostate cancer to vary across populations. However, natural selection is not the primary driver of these differences. Comparing continental datasets, we find that polygenic predictions of case vs. control status are more effective for European individuals (AUC 0.608–0.707, OR 2.37–5.71) than for African individuals (AUC 0.502–0.585, OR 0.95–2.01). Furthermore, PRS that leverage information from African Americans yield modest AUC and odds ratio improvements for sub-Saharan African individuals. These improvements were larger for West Africans than for South Africans. Finally, we find that existing PRS are largely unable to predict whether African individuals develop aggressive forms of prostate cancer, as specified by higher tumor stages or Gleason scores. Conclusions Genetic predictions of prostate cancer perform poorly if the study sample does not match the ancestry of the original GWAS. PRS built from European GWAS may be inadequate for application in non-European populations and perpetuate existing health disparities.
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- 2022
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32. Predicting Complications in 153 Lumbar Pedicle Subtraction Osteotomies by a Single Surgeon Over a 6-Year Period
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Baker, Seth C., primary, Lucasti, Christopher, additional, Graham, Benjamin C., additional, Scott, Maxwell M., additional, Vallee, Emily K., additional, Kowalski, David, additional, Patel, Dil V., additional, and Hamill, Christopher L., additional
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- 2024
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33. Unified Approach to Deamination and Deoxygenation Through Isonitrile Hydrodecyanation: A Combined Experimental and Computational Investigation
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Jiao, Ziqi, primary, Jaunich, Kyle T., additional, Tao, Thomas, additional, Gottschall, Olivia, additional, Hughes, Maxwell M., additional, Turlik, Aneta, additional, and Schuppe, Alexander, additional
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- 2024
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34. Fatal drug use in the COVID-19 pandemic response: Changing trends in drug-involved deaths before and after stay-at-home orders in Louisiana
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Maxwell M. Leonhardt, John R. Spartz, Arti Shankar, and Stephen A. Murphy
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disaster mental health ,overdose death ,COVID-19 ,opioid ,fentanyl ,stimulant ,Public aspects of medicine ,RA1-1270 - Abstract
The effect of disaster events on increasing drug-involved deaths has been clearly shown in previous literature. As the COVID-19 pandemic led to stay-at-home orders throughout the United States, there was a simultaneous spike in drug-involved deaths around the country. The landscape of a preexisting epidemic of drug-involved deaths in the United States is one which is not geographically homogenous. Given this unequal distribution of mortality, state-specific analysis of changing trends in drug use and drug-involved deaths is vital to inform both care for people who use drugs and local policy. An analysis of public health surveillance data from the state of Louisiana, both before and after the initial stay-at-home order of the COVID-19 pandemic, was used to determine the effect the pandemic may have had on the drug-involved deaths within this state. Using the linear regression analysis of total drug-involved deaths, as well as drug-specific subgroups, trends were measured based on quarterly (Qly) deaths. With the initial stay-at-home order as the change point, trends measured through quarter 1 (Q1) of 2020 were compared to trends measured from quarter 2 (Q2) of 2020 through quarter 3 (Q3) of 2021. The significantly increased rate of change in Qly drug-involved deaths, synthetic opioid-involved deaths, stimulant-involved deaths, and psychostimulant-involved deaths indicates a long-term change following the initial response to the COVID-19 pandemic. Changes in the delivery of mental health services, harm reduction services, medication for opioid use disorder (MOUD), treatment services, withdrawal management services, addiction counseling, shelters, housing, and food supplies further limited drug-involved prevention support, all of which were exacerbated by the new stress of living in a pandemic and economic uncertainty.
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- 2023
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35. Assessment of Community Awareness and Screening of Chagas Disease in the Latin American Community of Greater New Orleans
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Claudia Herrera, Kerlly J. Bernabé, Eric Dumonteil, James DeCuir, Julie M. Thompson, Mariana Avendano, Weihong Tu, Maxwell M. Leonhardt, Bianka A. Northland, Jynx Frederick, Bryn Prieto, Angel Paternina-Caicedo, Emma Ortega, Maria Fonseca, Marcela Hincapie, and Margarita Echeverri
- Subjects
Trypanosoma cruzi ,diagnostic ,surveillance ,screening ,Chagas disease barriers ,Latin American community ,Medicine - Abstract
Chagas disease is a public health problem in the Americas, from the southern United States (USA) to Argentina. In the USA, less than 1% of domestic cases have been identified and less than 0.3% of total cases have received treatment. Little is known about affected immigrant Latin American communities. A prospective study was conducted to assess knowledge about Chagas disease among the Latin American community living in the Greater New Orleans area. Participants answered a baseline questionnaire, viewed a short educational video presentation, completed a post-presentation questionnaire, and were screened with an FDA-approved blood rapid diagnostic test (RDT). A total of 154 participants from 18 Latin American countries (n = 138) and the USA (n = 16) were enrolled and screened for Trypanosoma cruzi infection. At baseline, 57% of the participants knew that Chagas disease is transmitted through an insect vector, and 26% recognized images of the vector. Following the administration of an educational intervention, the participants’ knowledge regarding vector transmission increased to 91% and 35% of participants were able to successfully identify images of the vector. Five participants screened positive for T. cruzi infection, indicating a 3.24% [95%CI: 1.1–7.5%] prevalence of Trypanosoma cruzi infection within the Latin American community of the New Orleans area. Results highlight the urgent need for improving access to education and diagnostics of Chagas disease.
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- 2023
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36. Early Surgical Treatment of Thoracolumbar Fractures With Thoracolumbar Injury Classification and Severity Scores Less Than 4
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Lucasti, Christopher, Scott, Maxwell M., Slowinski, Joshua, Maraschiello, Mark, Clark, Lindsey D., and Kowalski, Joseph M.
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- 2023
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37. Association between the choice of the conditioning regimen and outcomes of allogeneic hematopoietic cell transplantation for myelofibrosis
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Guru Subramanian Guru Murthy, Soyoung Kim, Noel Estrada-Merly, Muhammad Bilal Abid, Mahmoud Aljurf, Amer Assal, Talha Badar, Sherif M. Badawy, Karen Ballen, Amer Beitinjaneh, Jan Cerny, Saurabh Chhabra, Zachariah DeFilipp, Bhagirathbhai Dholaria, Miguel Angel Diaz Perez, Shatha Farhan, Cesar O. Freytes, Robert Peter Gale, Siddhartha Ganguly, Vikas Gupta, Michael R. Grunwald, Nada Hamad, Gerhard C. Hildebrandt, Yoshihiro Inamoto, Tania Jain, Omer Jamy, Mark Juckett, Matt Kalaycio, Maxwell M. Krem, Hillard M. Lazarus, Mark Litzow, Reinhold Munker, Hemant S. Murthy, Sunita Nathan, Taiga Nishihori, Guillermo Ortí, Sagar S. Patel, Marjolein van der Poel, David A. Rizzieri, Bipin N. Savani, Sachiko Seo, Melhem Solh, Leo F. Verdonck, Baldeep Wirk, Jean A. Yared, Ryotaro Nakamura, Betul Oran, Bart Scott, and Wael Saber
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only curative treatment for myelofibrosis. However, the optimal conditioning regimen either with reduced-intensity conditioning (RIC) or myeloablative conditioning (MAC) is not well known. Using the Center for International Blood and Marrow Transplant Research database, we identified adults aged ≥18 years with myelofibrosis undergoing allo-HCT between 2008-2019 and analyzed the outcomes separately in the RIC and MAC cohorts based on the conditioning regimens used. Among 872 eligible patients, 493 underwent allo-HCT using RIC (fludarabine/ busulfan n=166, fludarabine/melphalan n=327) and 379 using MAC (fludarabine/busulfan n=247, busulfan/cyclophosphamide n=132). In multivariable analysis with RIC, fludarabine/melphalan was associated with inferior overall survival (hazard ratio [HR]=1.80; 95% confidenec interval [CI]: 1.15-2.81; P=0.009), higher early non-relapse mortality (HR=1.81; 95% CI: 1.12-2.91; P=0.01) and higher acute graft-versus-host disease (GvHD) (grade 2-4 HR=1.45; 95% CI: 1.03-2.03; P=0.03; grade 3-4 HR=2.21; 95%CI: 1.28-3.83; P=0.004) compared to fludarabine/busulfan. In the MAC setting, busulfan/cyclophosphamide was associated with a higher acute GvHD (grade 2-4 HR=2.33; 95% CI: 1.67-3.25; P
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- 2023
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38. Noninfectious Pulmonary Toxicity after Allogeneic Hematopoietic Cell Transplantation
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Patel, Sagar S., Ahn, Kwang Woo, Khanal, Manoj, Bupp, Caitrin, Allbee-Johnson, Mariam, Majhail, Navneet S., Hamilton, Betty K., Rotz, Seth J., Hashem, Hasan, Beitinjaneh, Amer, Lazarus, Hillard M., Krem, Maxwell M., Prestidge, Tim, Bhatt, Neel S., Sharma, Akshay, Gadalla, Shahinaz M., Murthy, Hemant S., Broglie, Larisa, Nishihori, Taiga, Freytes, César O., Hildebrandt, Gerhard C., Gergis, Usama, Seo, Sachiko, Wirk, Baldeep, Pasquini, Marcelo C., Savani, Bipin N., Sorror, Mohamed L., Stadtmauer, Edward A., and Chhabra, Saurabh
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- 2022
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39. Testing the generalizability of ancestry-specific polygenic risk scores to predict prostate cancer in sub-Saharan Africa
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Kim, Michelle S., Naidoo, Daphne, Hazra, Ujani, Quiver, Melanie H., Chen, Wenlong C., Simonti, Corinne N., Kachambwa, Paidamoyo, Harlemon, Maxine, Agalliu, Ilir, Baichoo, Shakuntala, Fernandez, Pedro, Hsing, Ann W., Jalloh, Mohamed, Gueye, Serigne M., Niang, Lamine, Diop, Halimatou, Ndoye, Medina, Snyper, Nana Yaa, Adusei, Ben, Mensah, James E., Abrahams, Afua O. D., Biritwum, Richard, Adjei, Andrew A., Adebiyi, Akindele O., Shittu, Olayiwola, Ogunbiyi, Olufemi, Adebayo, Sikiru, Aisuodionoe-Shadrach, Oseremen I., Nwegbu, Maxwell M., Ajibola, Hafees O., Oluwole, Olabode P., Jamda, Mustapha A., Singh, Elvira, Pentz, Audrey, Joffe, Maureen, Darst, Burcu F., Conti, David V., Haiman, Christopher A., Spies, Petrus V., van der Merwe, André, Rohan, Thomas E., Jacobson, Judith, Neugut, Alfred I., McBride, Jo, Andrews, Caroline, Petersen, Lindsay N., Rebbeck, Timothy R., and Lachance, Joseph
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- 2022
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40. Raising awareness of pre-conception care in community pharmacies: a feasibility study
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Eastwood, KA, Allen-Walker, V. A., Maxwell, M., and McKinley, M. C.
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- 2022
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41. ScanCloud: Holistic GPR Data Analysis for Adaptive Subsurface Object Detection.
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Maxwell M. Omwenga, Dalei Wu, Yu Liang, Dryver Huston, and Tian Xia 0005
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- 2021
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42. Chronic Graft-Versus-Host Disease
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Krem, Maxwell M., Hildebrandt, Gerhard C., Maziarz, Richard T., editor, and Slater, Susan Schubach, editor
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- 2021
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43. Haploidentical vs sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia
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Wieduwilt, Matthew J., Metheny, Leland, III, Zhang, Mei-Jie, Wang, Hai-Lin, Estrada-Merly, Noel, Marks, David I., Al-Homsi, A. Samer, Muffly, Lori, Chao, Nelson, Rizzieri, David, Gale, Robert Peter, Gadalla, Shahinaz M., Cairo, Mitchell, Mussetti, Alberto, Gore, Steven, Bhatt, Vijaya Raj, Patel, Sagar S., Michelis, Fotios V., Inamoto, Yoshihiro, Badawy, Sherif M., Copelan, Edward, Palmisiano, Neil, Kharfan-Dabaja, Mohamed A., Lazarus, Hillard M., Ganguly, Siddhartha, Bredeson, Christopher, Diaz Perez, Miguel Angel, Cassaday, Ryan, Savani, Bipin N., Ballen, Karen, Martino, Rodrigo, Wirk, Baldeep, Bacher, Ulrike, Aljurf, Mahmoud, Bashey, Asad, Murthy, Hemant S., Yared, Jean A., Aldoss, Ibrahim, Farhadfar, Nosha, Liu, Hongtao, Abdel-Azim, Hisham, Waller, Edmund K., Solh, Melhem, Seftel, Matthew D., van der Poel, Marjolein, Grunwald, Michael R., Liesveld, Jane L., Kamble, Rammurti T., McGuirk, Joseph, Munker, Reinhold, Cahn, Jean-Yves, Lee, Jong Wook, Freytes, César O., Krem, Maxwell M., Winestone, Lena E., Gergis, Usama, Nathan, Sunita, Olsson, Richard F., Verdonck, Leo F., Sharma, Akshay, Ringdén, Olle, Friend, Brian D., Cerny, Jan, Choe, Hannah, Chhabra, Saurabh, Nishihori, Taiga, Seo, Sachiko, George, Biju, Baxter-Lowe, Lee Ann, Hildebrandt, Gerhard C., de Lima, Marcos, Litzow, Mark, Kebriaei, Partow, Hourigan, Christopher S., Abid, Muhammad Bilal, Weisdorf, Daniel J., and Saber, Wael
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- 2022
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44. Predicting Complications in 153 Lumbar Pedicle Subtraction Osteotomies by a Single Surgeon Overa 6-Year Period.
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Baker, Seth C., Lucasti, Christopher, Graham, Benjamin C., Scott, Maxwell M., Vallee, Emily K., Kowalski, David, Patel, Dil V., and Hamill, Christopher L.
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- 2024
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45. Differences in Financial Conflicts of Interest Among Participants in a National Spine Conference.
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Lucasti, Christopher, Vallee, Emily K, Scott, Maxwell M, Baker, Seth C, Das, Ashtah A, and Patel, Dil V
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PATIENT Protection & Affordable Care Act ,ORTHOPEDISTS ,SURGERY practice ,PHYSICIAN practice patterns ,SPINAL surgery - Abstract
Study Design: Retrospective Study. Objective: At the North American Spine Society (NASS) conference, participants may influence spine surgery practices and patient care through their contributions. Therefore, their financial conflicts of interest are of notable interest. This study aims to compare the demographics and payments made to participating surgeons. Methods: A list of 151 spine surgeons was created based on those who participated in the 2022 NASS conference. Demographic information was obtained from public physician profiles. General payments, research payments, associated research funding, and ownership interest were collected for each physician. Descriptive statistics and two-tailed t-tests were used. Results: In 2021, 151 spine surgeon participants received industry payments, totaling USD 48 294 115. The top 10% of orthopedic surgeons receiving payments accounted for 58.7% of total orthopedic general value, while the top 10% of neurosurgeons accounted for 70.1%. There was no significant difference between these groups' general payment amounts. Surgeons with 21-30 years of experience received the most general funding. There was no difference in funding between surgeons in academic or private settings. For all surgeons, royalties accounted for the largest percentage of the general value exchanged, while food/beverage accounted for the largest percentage of transactions. Conclusion: Our study found that only years of experience had a positive association with general payments, and most monetary value belonged to a small handful of surgeons. These participants receiving significant money may promote techniques requiring products of companies providing their compensation. Future conferences may require disclosure policy changes so attendees understand the degree of funding participants receive. [ABSTRACT FROM AUTHOR]
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- 2024
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46. Research on Continuous Improvement: Exploring the Complexities of Managing Educational Change
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Yurkofsky, Maxwell M., Peterson, Amelia J., Mehta, Jal D., Horwitz-Willis, Rebecca, and Frumin, Kim M.
- Abstract
As a result of the frustration with the dominant "What Works" paradigm of large-scale research-based improvement, practitioners, researchers, foundations, and policymakers are increasingly embracing a set of ideas and practices that can be collectively labeled continuous improvement (CI) methods. This chapter provides a comparative review of these methods, paying particular attention to CI methods' intellectual influences, theories of action, and affordances and challenges in practice. We first map out and explore the shared intellectual forebears that CI methods draw on. We then discuss three kinds of complexity to which CI methods explicitly attend--ambiguity, variability, and interdependence--and how CI methods seek a balance of local and formal knowledge in response to this complexity. We go on to argue that CI methods are generally less attentive to the relational and political dimensions of educational change and that this leads to challenges in practice. We conclude by considering CI methods' aspirations for impact at scale, and offer a number of recommendations to inform future research and practice.
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- 2020
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47. Analyzing Instructionally Focused Education Systems: Exploring the Coordinated Use of Complementary Frameworks
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Peurach, Donald J., Yurkofsky, Maxwell M., Blaushild, Naomi, Sutherland, Daniella Hall, and Spillane, James P.
- Abstract
Public school districts have been operating under a decade's long press to move beyond functioning as engines of access-oriented mass public schooling to functioning as instructionally focused education systems pursuing educational excellence and equity. This press has researchers developing analytic frameworks useful for examining different ways that districts are responding. Even so, limitations in individual frameworks suggest a need to explore the coordinate use of complementary frameworks to support more comprehensive examinations of districts. This analysis explores the coordinated use of a "coupling framework" and a "systems framework" to analyze efforts in two districts to improve educational quality and to reduce disparities. Findings suggests that the coordinated use of the coupling and systems frameworks supports deeper analyses of instructional organization and management than either framework would on its own, and that further incorporating quality and equity frameworks would support still-deeper analyses. From the perspective of this issue of the "Peabody Journal of Education" (PJE), the implication is that elaborating new institutional theory to capture micro-level variation in response to macro-level dynamics is but one challenge faced by organizational researchers in education, and that the deeper challenge lies in considering alternative world views--paradigmatic assumptions--underlying the use of singular and complementary analytic frameworks.
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- 2020
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48. Technical Ceremonies: Rationalization, Opacity, and the Restructuring of Educational Organizations
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Yurkofsky, Maxwell M.
- Abstract
After decades of accountability and market-based reforms in education, school systems are now organizing more around improving teaching and learning. Yet these efforts frequently yield unintended, superficial, or even counterproductive changes at the school level. In this article, Maxwell Yurkofsky develops the concept of technical ceremonies as a way of theorizing this emerging pattern of school organizations. Technical ceremonies involve educators changing their practice to align with new reforms in a way that privileges what is visible and measurable as a way of appeasing external stakeholders over more substantive improvements to practice. He argues that technical ceremonies arise as principals navigate a multitude of surface-level demands from the environment and the uncertainties that pervade efforts to transform teaching and learning.
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- 2020
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49. The SERCA residue Glu340 mediates interdomain communication that guides Ca 2+ transport
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Geurts, Maxwell M. G., Clausen, Johannes D., Arnou, Bertrand, Montigny, Cédric, Lenoir, Guillaume, Corey, Robin A., Jaxel, Christine, Møller, Jesper V., Nissen, Poul, Andersen, Jens Peter, le Maire, Marc, and Bublitz, Maike
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- 2020
50. The Second Data Release of the Beijing-Arizona Sky Survey
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Zou, H, Zhang, T, Zhou, Z, Peng, X, Nie, J, Zhou, X, Fan, X, Jiang, L, McGreer, I, Dey, A, Fan, D, Findlay, JR, Gao, J, Gu, Y, Guo, Y, He, B, Jin, J, Kong, X, Lang, D, Lei, F, Lesser, M, Li, F, Ma, J, Meng, X, Maxwell, M, Myers, AD, Rui, L, Schlegel, D, Sun, F, Wu, H, Wang, J, and Yuan, Q
- Subjects
surveys ,techniques: image processing ,techniques: photometric ,Astronomy & Astrophysics ,Astronomical and Space Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Physical Chemistry ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Physical Chemistry (incl. Structural) - Abstract
This paper describes the second data release (DR2) of the Beijing-Arizona Sky Survey (BASS). BASS is an imaging survey covering a 5400 deg2 footprint in the g and r bands using the 2.3 m Bok telescope. DR2 includes the observations through 2017 July obtained by BASS and by the Mayall z-band Legacy Survey (MzLS), which used the 4 m Mayall telescope to observe the same footprint. BASS and MzLS have completed 72% and 76% of their observations. The two surveys will be served for the spectroscopic targeting of the upcoming Dark Energy Spectroscopic Instrument. Both BASS and MzLS data are reduced by the same pipeline. We have updated the basic data reduction and photometric calibrations in DR2. In particular, source detections are performed on stacked images, and photometric measurements are co-added from single-epoch images based on these sources. The median 5σ point-source depths after Galactic extinction corrections are 24.05, 23.61, and 23.10 mag for the g, r, and z bands, respectively. The DR2 data products include stacked images, co-added catalogs, and single-epoch images and catalogs. The BASS website (http://batc.bao.ac.cn/BASS/) provides detailed information and links to download the data.
- Published
- 2018
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