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17 results on '"Maxson, Tucker"'

1. Genetic basis of clarithromycin resistance in Bacillus anthracis

Author

Maxson, Tucker, primary, Overholt, Will A., additional, Chivukula, Vasanta, additional, Caban-Figueroa, Victoria, additional, Kongphet-Tran, Thiphasone, additional, Medina Cordoba, Luz K., additional, Cherney, Blake, additional, Rishishwar, Lavanya, additional, Conley, Andrew, additional, and Sue, David, additional

Published
2024
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3. Systematic Review of In Vitro Antimicrobial Susceptibility Testing for Bacillus anthracis, 1947–2019

Author

Maxson, Tucker, primary, Kongphet-Tran, Thiphasone, additional, Mongkolrattanothai, Thitipong, additional, Travis, Tatiana, additional, Hendricks, Katherine, additional, Parker, Corinne, additional, McLaughlin, Heather P, additional, Bugrysheva, Julia, additional, Ambrosio, Frank, additional, Michel, Pierre, additional, Cherney, Blake, additional, Lascols, Christine, additional, and Sue, David, additional

Published
2022
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5. Fluorescent ribonucleoside as a FRET acceptor for tryptophan in native proteins

Author

Yun Xie, Maxson, Tucker, and Yitzhak Tor

Subjects
Azo compounds -- Structure, Azo compounds -- Chemical properties, Azo compounds -- Optical properties, Fluorescence -- Analysis, Ribonucleotides -- Structure, Ribonucleotides -- Chemical properties, Tryptophan -- Structure, Tryptophan -- Chemical properties, Tryptophan -- Optical properties, Chemistry
Abstract

The preparation, structure and properties of a new fluorescent ribonucleoside analogue containing 5-aminoquinazoline-2,4(1H,3H)-dione are discussed. The compound is shown to be extremely useful as a FRET acceptor and can be implied to the tryptophan present in the native proteins.

Published
2010

16. Plantazolicin is an ultra-narrow spectrum antibiotic that targets the Bacillus anthracis membrane.

Author

Molohon KJ, Saint-Vincent PMB, Park S, Doroghazi JR, Maxson T, Hershfield JR, Flatt KM, Schroeder NE, Ha T, and Mitchell DA

Abstract

Plantazolicin (PZN) is a ribosomally synthesized and post-translationally modified natural product from Bacillus methylotrophicus FZB42 and Bacillus pumilus . Extensive tailoring to twelve of the fourteen amino acid residues in the mature natural product endows PZN with not only a rigid, polyheterocyclic structure, but also antibacterial activity. Here we report a remarkably discriminatory activity of PZN toward Bacillus anthracis , which rivals a previously-described gamma (γ) phage lysis assay in distinguishing B. anthracis from other members of the Bacillus cereus group. We evaluate the underlying cause of this selective activity by measuring the RNA expression profile of PZN-treated B. anthracis , which revealed significant upregulation of genes within the cell envelope stress response. PZN depolarizes the B. anthracis membrane like other cell envelope-acting compounds but uniquely localizes to distinct foci within the envelope. Selection and whole-genome sequencing of PZN-resistant mutants of B. anthracis implicate a relationship between the action of PZN and cardiolipin (CL) within the membrane. Exogenous CL increases the potency of PZN in wild type B. anthracis and promotes the incorporation of fluorescently tagged PZN in the cell envelope. We propose that PZN localizes to and exacerbates structurally compromised regions of the bacterial membrane, which ultimately results in cell lysis.

Published
2016
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17. Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitro-benzamido)-2-hy-droxy-prop-yl]deca-hydro-isoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitro-benzoyl)pyrrolidin-2-yl]-2-hy-droxy-eth-yl}deca-hydro-iso-quinoline-3-carboxamide.

Author

Maxson T, Bertke JA, Gray DL, and Mitchell DA

Abstract

The crystal structure and absolute configuration of the two new title nelfinavir analogs, C24H35ClN4O5, (I), and C27H39ClN4O5, (II), have been determined. Each of these mol-ecules exhibits a number of disordered moieties. There are intra-molecular N-H⋯O hydrogen bonds in both (I) and (II). In (I) it involves the two carboxamide groups, while in (II) it involves the N-tert-butyl carboxamide group and the 2-hydroxyl O atom. The inter-molecular hydrogen bonding in (I) (O-H⋯O and N-H⋯O) leads to two-dimensional sheets that extend parallel to the ac plane. The inter-molecular hydrogen bonding in (II) (O-H⋯O) leads to chains that extend parallel to the a axis.

Published
2015
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