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Background Multiples of resting metabolic rate (RMR) are often used to classify physical activity intensity, a concept known as the metabolic equivalent of task (MET). However, the METs metrics may misclassify physical activity intensity in older adults because of age-related changes in RMR and maximal aerobic capacity (⁠ V ˙ O 2 max). This study aimed to (i) compare classifications of activity intensity by estimated (METsestimated) and measured (METsmeasured) METs and (ii) compare physical activity classified by absolute (METsmeasured) versus relative intensity (% V ˙ O 2 Reserve) in older adults. Methods Ninety-eight adults aged 75–90 years participated in the study. RMR and V ˙ O 2 during sitting, standing, daily activities, and 6-minute walking test were measured. V ˙ O 2 Reserve was defined as the difference between V ˙ O 2 max and RMR. Moderate and vigorous intensity was classified as 3 and 6 METs and 40% and 60% of V ˙ O 2 Reserve, respectively. Paired t tests and a confusion matrix were used to investigate aims 1 and 2, respectively. Results METsmeasured was 24% lower than the standard 1 MET of 3.5 mL O2·min−1·kg−1. METsestimated underestimated the intensity during daily and walking activities when compared to METsmeasured. Nevertheless, when comparing METsmeasured to percentages of V ˙ O 2 Reserve, a mismatch was shown for moderate intensity in 47%–67% of the participants during daily activities and 21% of the participants during self-selected gait speed. Conclusions Applying METsestimated for older adults leads to potential underestimation of physical activity intensity, suggesting that current classification metrics should be revised for older adults. V ˙ O 2 Reserve is a candidate metric for establishing precise physical activity intensity cut points for older adults. Clinical Trials Registration Number: NCT04821713 [ABSTRACT FROM AUTHOR]

Background and Purpose: Firefighting is a high-risk profession that requires high physical fitness, and it is important to have regular exercise to maintain optimal physical fitness and health. However, there is a little research on the best types and methods of training to improve the performance of firefighters and reduce the volume of self-contained breathing apparatus (SCBA) used in duty. Therefore, the purpose of this study was to investigate and compare the effect of 8 weeks of high-intensity interval and functional training on cardiorespiratory fitness (VO2max) and the used volume of SCBA in firefighters. Materials and Methods: Thirty-nine firefighters working in the fire department of Tehran participated in the study and were randomly allocated in the three groups of control, HIIT and HIFT. Subjects in HIIT group performed 8 weeks of Tabata exercises with body weight, which were 4 exercises in the first two weeks and were increased to 6 and 8 exercises in the 6th and 8th weeks, respectively. In each session, they had 10 min general warm up, thereafter they performed 8 sets of each exercise, where sets included 20 s activity followed by 10 s rest and 2 min rest was allowed between exercises. Subjects in HIFT group had similar program to the HIIT group, with the exception that the exercises they performed were those exercises in the standard simulated test for firefighters which were performed based on the Tabata methods (20 s activity followed by 10 s rest). Two days before training and 48 hours after the last training session the VO2max test (Bruce’s protocol) and simulated firefighting test were carried out. Results: The statistical analysis of the data showed that HIFT and HIIT caused a significant increase in maximal oxygen uptake (VO2max) and performance, and a significant decrease in the volume of SCBA used in firefighters (p<0.05), though, these changes were not significantly different between HIIT and HIFT groups (p<0.05). VO2max increased by 6.35% and 4.26% in HIFT and HIIT groups, and performance increased by 5.21 and 4.74%, following HIFT and HIIT, respectively. In addition, VO2/HR increased by 11.64 and 6.52% in HIIT and HIIT groups, respectively, while, the volume of SCBA used decreased by 14.41% and 11.44%, respectively. However, the results of repeated measures of ANOVA showed no significant between-group differences for RER (P=0.269), HR (P=0.595), VE (P=0.392), VE/VO2 ratio (P0.778) =) and VE/VCO2 ratio (P=0.778). Conclusion: According to the results of the present study it could be concluded that 8 weeks of HIFT and HIIT can improve cardiorespiratory fitness (VO2max), performance, and the volume of SCBA used in firefighters, and that performing these types of training based on the Tabata’s method is advised to firefighters. [ABSTRACT FROM AUTHOR]

We aimed to evaluate long-term changes in proteinogenic and non-proteinogenic plasma free amino acids (PFAA). Eleven male endurance triathletes participated in a 9-month study. Blood was collected at rest, immediately after exhaustive exercise, and during 30-min recovery, in four consecutive training phases: transition, general, specific, and competition. Twenty proteinogenic and 22 non-proteinogenic PFAAs were assayed using the LC-ESI-MS/MS technique. The structured training modified the patterns of exercise-induced PFAA response, with the competition phase being the most distinct from the others. Branched-chain amino acids (p = 0.002; η2 = 0.216), phenylalanine (p = 0.015; η2 = 0.153), methionine (p = 0.002; η2 = 0.206), and lysine (p = 0.006; η2 = 0.196) declined more rapidly between rest and exhaustion in the competition phase. Glutamine (p = 0.008; η2 = 0.255), glutamate (p = 0.006; η2 = 0.265), tyrosine (p = 0.001; η2 = 0.195), cystine (p = 0.042; η2 = 0.183), and serine (p < 0.001; η2 = 0.346) levels were reduced in the competition phase. Arginine (p = 0.046; η2 = 0.138) and aspartate (p = 0.011; η2 = 0.171) levels were highest during exercise in the transition phase. During the competition phase, α-aminoadipic acid (p = 0.023; η2 = 0.145), β-aminoisobutyric acid (p = 0.007; η2 = 0.167), β-alanine (p < 0.001; η2 = 0.473), and sarcosine (p = 0.017; η2 = 0.150) levels increased, whereas phosphoethanolamine (p = 0.037; η2 = 0.189) and taurine (p = 0.008; η2 = 0.251) concentrations decreased. Overtraining indicators were not elevated. The altered PFAA profile suggests adaptations within energy metabolic pathways such as the tricarboxylic acid cycle, oxidative phosphorylation, ammonia neutralization, the purine nucleotide cycle, and buffering of intracellular H+ ions. The changes seem to reflect normal adaptations. [ABSTRACT FROM AUTHOR]

Background and Purpose: Firefighting is a high-risk profession that requires high physical fitness, and it is important to have regular exercise to maintain optimal physical fitness and health. However, there is a little research on the best types and methods of training to improve the performance of firefighters and reduce the volume of self-contained breathing apparatus (SCBA) used in duty. Therefore, the purpose of this study was to investigate and compare the effect of 8 weeks of high-intensity interval and functional training on cardiorespiratory fitness (VO2max) and the used volume of SCBA in firefighters.Materials and Methods: Thirty-nine firefighters working in the fire department of Tehran participated in the study and were randomly allocated in the three groups of control, HIIT and HIFT. Subjects in HIIT group performed 8 weeks of Tabata exercises with body weight, which were 4 exercises in the first two weeks and were increased to 6 and 8 exercises in the 6th and 8th weeks, respectively. In each session, they had 10 min general warm up, thereafter they performed 8 sets of each exercise, where sets included 20 s activity followed by 10 s rest and 2 min rest was allowed between exercises. Subjects in HIFT group had similar program to the HIIT group, with the exception that the exercises they performed were those exercises in the standard simulated test for firefighters which were performed based on the Tabata methods (20 s activity followed by 10 s rest). Two days before training and 48 hours after the last training session the VO2max test (Bruce’s protocol) and simulated firefighting test were carried out.Results: The statistical analysis of the data showed that HIFT and HIIT caused a significant increase in maximal oxygen uptake (VO2max) and performance, and a significant decrease in the volume of SCBA used in firefighters (p

A systematic review with meta-analysis was conducted to evaluate the effects of circuit resistance training (CRT) on cardiorespiratory fitness, strength, and body composition in middle-aged and older women. Sixteen studies were included in the meta-analysis. The CRT interventions led to a significant decrease in weight, body mass index, and fat mass along with an increase in muscle mass. Significant differences were found in the fat mass and a trend to develop muscle mass when compared with the control group. CRT led to a significant increase in VO2max, walking endurance, and time to exhaustion; likewise, significant differences were observed when compared with the control group. CRT had a moderate and large favorable effect on arm, trunk, and lower limb strength. Furthermore, the increases in strength observed in the CRT were significantly greater than the changes observed in the control group. In middle-aged and older women, CRT improved cardiorespiratory fitness and strength and optimized body composition. [ABSTRACT FROM AUTHOR]

As cardiorespiratory capacity is an important factor of an overall quality of life and a significant indicator of physical fitness, its development should begin from early childhood. The goal of the research is to determine the differences in the quality of life and cardiorespiratory abilities of primary education students. A total of 651 fourth-grade primary school students from the Republic of Croatia participated in the research. The average age of the subjects was 10.38±0.50 years, and the sample was divided in two subsamples according to gender, 316 girls (10.30±0.47 years) and 335 boys (10.34±0.49 years). Body height was measured with a portable altimeter, while body mass, body mass index -- BMI, percentage of fat, level of obesity, and muscle mass were measured with a two-frequency body composition analyser (TANITA DC-360P). Waist circumference and hip circumference were measured with a centimeter tape, while the ratio of the waist and hip circumference (WHR index) was calculated based on their ratio. Cardiorespiratory capacity was assessed with a multi-stage 20m-running test (20MSRT Shuttle run test). For assessing the qualty of life, the researchers used a Croatian version of the KIDSCREEN-10 Questionnaire. The research results show a high mean value of the overall life quality assessment (4.33). The identification of individual differences between the researched groups demonstrated that students with a high level of cardiorespiratory capacity rate their quality of life significantly higher than students with a low or moderate cardiorespiratory capacity. According to the results, 41.01% of students have an unsatisfactory level of cardiorespiratory ability. There are statistically significant differences in morphological characteristics and cardiorespiraory capacity among the groups classified according to their level of cardiorespiratory capacity. Children with a higher level of cardiorespiratory capacity report a better quality of life and have better indeces of physical nutrition. Physical exercises used to boost the development of the cardiorespiratory capacity of children indirectly impact the prevention of obesity and can diminish other factors of cardiovascular risk. [ABSTRACT FROM AUTHOR]

BackgroundPhysical exertion during exercise often leads to increased oxidative stress and inflammatory responses, significantly affecting physical performance. Current strategies to mitigate these effects are limited by their effectiveness and potential side effects. Molecular hydrogen (H₂) has gained attention for its antioxidant and anti-inflammatory properties. Studies have suggested that H2 supplementation contributes to antioxidant potential and anti-fatigue during exercise, but the variance in the observations and study protocols is presented across those studies.ObjectiveThis systematic review and meta-analysis aimed to comprehensively characterize the effects of H₂ supplementation on physical performance (i.e., endurance, muscular strength, and explosive power), providing knowledge that can inform strategies using H2 for enhancing physical performance.MethodsWe conducted a literature search of six databases (PubMed, Web of Science, Medline, Sport-Discus, Embase, and PsycINFO) according to the PRISMA guidelines. The data were extracted from the included studies and converted into the standardized mean difference (SMD). After that, we performed random-effects meta-analyses and used the I2 statistic to evaluate heterogeneity. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to assess the quality of the evidence obtained from this meta-analysis.ResultsIn total, 27 publications consisting of 597 participants were included. The search finally included aerobic endurance, anaerobic endurance, muscular strength, lower limb explosive power, rating of perceived exertion (RPE), blood lactate (BLA), and average heart rate (HRavg) in the effect size (ES) synthesis. The ES of H2 on aerobic endurance, including V̇O2max (SMD = 0.09, p = 0.394; I2 = 0%) and aerobic endurance exercise (SMD = 0.04, p = 0.687; I2 = 0%), were not significant and trivial; the ES of H2 on 30 s maximal anaerobic endurance (SMD = 0.19, p = 0.239; I2 = 0%) was not significant and trivial; the ES of H2 on muscular strength (SMD = 0.19, p = 0.265; I2 = 0%) was not significant and trivial; but the ES of H2 on lower limb explosive power (SMD = 0.30, p = 0.018; I2 = 0%) was significant and small. In addition, H2 reduces RPE (SMD = −0.37, p = 0.009; I2 = 58.0%) and BLA (SMD = −0.37, p = 0.001; I2 = 22.0%) during exercise, but not HRavg (SMD = −0.27, p = 0.094; I2 = 0%).ConclusionThese findings suggest that H2 supplementation is favorable in healthy adults to improve lower limb explosive power, alleviate fatigue, and boost BLA clearance, but may not be effectively improving aerobic and anaerobic endurance and muscular strength. Future studies with more rigorous designs are thus needed to examine and confirm the effects of H2 on these important functionalities in humans.Systematic review registrationhttp://www.crd.york.ac.uk/PROSPERO.

Purpose: Laboratory tests are commonly performed by cross‐country (XC) skiers due to the challenges of obtaining reliable performance indicators on snow. However, only a few studies have reported reliability data for ski‐specific test protocols. Therefore, this study examined the test–retest reliability of ski‐specific aerobic, sprint, and neuromuscular performance tests. Methods: Thirty‐nine highly trained XC skiers (26 men and 13 women, age: 22 ± 4 years, V̇O2max: 70.1 ± 4.5 and 58.8 ± 4.4 mL·kg−1·min−1, respectively) performed two test trials within 6 days of a diagonal V̇O2max test, n = 27; skating graded exercise test to assess the second lactate threshold (LT2), n = 27; 24‐min double poling time trial (24‐min DP, n = 25), double poling sprint test (SprintDP1, n = 27), and 1‐min self‐paced skating sprint test (Sprint1‐min, n = 26) using roller skis on a treadmill, and an upper‐body strength test (UB‐ST, n = 27) to assess peak power (Ppeak) with light, medium, and heavy loads. For each test, the coefficient of variation (CV), intraclass correlation coefficient (ICC), and minimal detectable change (MDC) were calculated. Results: V̇O2max demonstrated good‐to‐excellent reliability (CV = 1.4%; ICC = 0.99; MDC = 112 mL·min−1), whereas moderate‐to‐excellent reliability was found for LT2 (CV = 3.1%; ICC = 0.95). Performance during 24‐min DP, SprintDP1, and Sprint1‐min showed good‐to‐excellent reliability (CV = 1.0%–2.3%; ICC = 0.96–0.99). Absolute reliability for UB‐ST Ppeak was poor (CV = 4.9%–7.8%), while relative reliability was excellent (ICC = 0.93–0.97) across the loads. Conclusion: In highly trained XC skiers, sport‐specific aerobic and sprint performance tests demonstrated high test–retest reliability, while neuromuscular performance for the upper body was less reliable. Using the presented protocols, practitioners can assess within‐ and between‐season changes in relevant performance indicators. [ABSTRACT FROM AUTHOR]

The aim of this study was to derive an equation that validly and reliably estimates the VO2 reached in the IPTL, a maximum stress test for lifeguards. From the results obtained in the first part of the research, a multiple linear regression model was identified. A "stepwise" procedure was established as a variable selection method, where the VO2IPTL was selected as the dependent variable and the maximum time reached in the IPTL (s), the percentage of muscle mass (%) and weight of the participant (kg), as independent variables. This procedure generated a regression model where a high correlation was observed between the 3 independent variables and the dependent variable (R2 = 0.84; p <.01). From this model, an equation could be generated that allows estimating the VO2max reached in the IPTL. The analysis of the results suggested that the IPTL was a valid and reliable test to estimate VO2 simply which would allow, in the long term, analysis of changes in lifeguards physical conditioning. [ABSTRACT FROM AUTHOR]

Background: Peak oxygen pulse (O2Ppeak) can reflect the condition of cardiovascular function and provide supplementary information for maximal oxygen uptake, but its direct measurement requires the precise instruments under the guidance of professionals, and the subjects should strive to the state of exhaustion. Objectives: The aim of the present cross-sectional study was to establish a prediction equation to estimate O2Ppeak of Chinese adults aged 20–39, from routine measures of anthropometry and cardiovascular function. Methods: 252 adults (20–39 years old) were recruited and randomly allocated to the validation group (n = 226) and the cross-validation group (n = 26). To be included in the study, subjects were required to be healthy, none-professional sports experience (healthy individuals who are not athletes or have had experience as athletes), and no medication taken recently. Subjects with cardiovascular diseases, lung disease and musculoskeletal diseases were excluded. The subjects’ anthropometric and cardiovascular variables were measured and each subject performed a maximal exercise test on an electromagnetic cycle ergometer. Results: The O2Ppeak estimated equation was developed using multiple linear regression models, O2Ppeak = 30.394 + 0.083 x body mass (kg) - 0.090 x resting heart rate (bpm) - 0.157 x age (years) - 2.710 x gender (1 = male, 2 = female) - 0.035 x systolic blood pressure (mmHg). The equation had the coefficient of determination (R2) = 0.804 and the standard error of estimate (SEE) = 1.619 ml/beat. An ANOVA and Akaike’s information criterion (AIC) were tested. Bland-Altman graphs were plotted to examine the distribution of bias. Cross-validation estimated O2Ppeak and directly measured O2Ppeak did not show significant difference while had a strong positive correlation (r = 0.89, p

Abstract Objective This study focused on evaluating whether high-intensity interval training (HIIT) had an effect on aerobic capacity and fatigue among patients with prostate cancer (PCa) and exploring its effect on the immune system of PCa patients. Methods To investigate the potential effect of HIIT on patients with prostate cancer, a meta-analysis was carried out. From January 2012 to August 2022, studies that met predefined criteria were searched in the Scopus, PubMed, Web of Science, and EBSCO databases. Analysis of the standardized mean differences was performed using Review Manager 5.4.1 software with a 95% confidence interval. Results This review examined a total of 6 articles. There were 215 male patients with PCa involved, and the mean age was 64.4 years. According to the results of the meta-analysis, the HIIT group (n = 63) had greater VO2peak (P

The study purpose was to compare the effects of concurrent resistance and aerobic training to resistance and/or aerobic training alone on body composition, muscular strength and maximum oxygen uptake in overweight and obese men. Materials and methods. Twenty-four overweight and obese (BMI = 23.0 - 29.9 kg/m²) volunteers who were male students from Ubon Ratchathani Rajabhat University, aged 19-22 years were assigned into 3 groups: 1) resistance training group (RT), 2) aerobic training group (AT) and 3) concurrent resistance and aerobic training group (RT+AT). The training was 45 minutes per session and 2 days per week. Body composition along with muscular strength (1-RM) and maximum oxygen uptake (VO2max) were measured before (2-3 days prior) and after (2-3 days post) a 5-week training period. Results. Waist circumference was significantly decreased in all three groups, but the RT+AT group also found improvement in percentages of fat-free mass (0.49 ± 0.49%, p = 0.021, mean ± SD) and skeletal muscle mass (1.01 ± 0.95%, p = 0.025) when compared to their baseline. Similarly, 1-RM in leg extension was significantly increased in all three groups, while the RT group (47.67 ± 14.85%, p = 0.01) and the RT+AT group (42.08 ± 21.70%, p = 0.039) showed a substantially larger improvement in the 1-RM in leg extension when compared to the AT group (20.37 ± 13.97%). Finally, VO2max was significantly increased in all three groups (baseline to post-intervention), though they were not significantly different between groups. Conclusions. Concurrent resistance and aerobic training can reduce waist circumference and increase fat-free mass, skeletal muscle mass, 1-RM and VO2max. Therefore, this training strategy may serve as a useful alternative way to improve overall physical fitness and health promotion in overweight to obese male population. [ABSTRACT FROM AUTHOR]

• 3D echo variables in single ventricle correlate with cardiopulmonary fitness. • 3D echo variables in single ventricle correlate with health-related QOL. • 3D echo reproducibility in single ventricle is good. • Feasibility of 3D echo in single ventricle should be improved. The prognosis of patients with a functional single ventricle has improved, with better cardiopulmonary fitness, health-related quality of life and survival. Conventional echocardiography remains the first-line technique in single ventricle follow-up. Three-dimensional (3D) echocardiography has shown recent value in congenital cardiology, but its ability to predict functional status in patients with a single ventricle remains unknown. To evaluate, in patients with a single ventricle, the association between 3D echocardiography variables and functional status determined by cardiopulmonary fitness. Children and adults with a functional single ventricle were prospectively enrolled in this multicentre study. Cardiopulmonary fitness was assessed by cardiopulmonary exercise test, with measures of maximum oxygen uptake (VO 2max) and ventilatory efficiency (VE/VCO 2 slope). 3D echocardiography was performed with off-line reproducibility analyses, using TomTec Arena™ software. Health-related quality of life was assessed using the SF-36 questionnaire. A total of 33 patients were screened, and 3D echocardiography analyses were feasible in 22 subjects (mean age 28 ± 9 years). 3D echocardiography ejection fraction correlated with percent-predicted VO 2max (r = 0.64, P < 0.01), VE/VCO 2 slope (r = –0.41, P = 0.05), two-dimensional echocardiography ejection fraction (r = 0.55, P < 0.01) and health-related quality of life physical functioning dimension (r = 0.56, P = 0.04). 3D echocardiography indexed end-systolic volume correlated with percent-predicted VO 2max (r = –0.45, P = 0.03) and VE/VCO 2 slope (r = 0.65, P < 0.01). 3D echocardiography reproducibility was good. Single ventricle ejection fraction and volumes measured by 3D echocardiography correlated with cardiopulmonary fitness, as determined by two main prognostic cardiopulmonary exercise test variables: VO 2max and VE/VCO 2 slope. Despite good reproducibility, 3D echocardiography feasibility remained limited. 3D echocardiography may be of value in single ventricle follow-up, provided that the technique and analysis software are improved. [ABSTRACT FROM AUTHOR]

Purpose: With a growing number of athletes and coaches adopting altitude training, the importance for rationalizing and optimizing such training has been emphasized. We conducted a meta-analysis to evaluate the influence of altitude training on athletes' aerobic capacity and to explore the best altitude training method to improve this capacity. Methods: We searched Web of Science, SpringerLink, Science Direct, EBSCO, and PubMed databases combined with manual search of the references to collect studies indexed from 1979 to September 2020 on the effect of altitude training on athletes' aerobic capacity. Data from experimental studies that reported hemoglobin levels and maximum oxygen uptake in athletes before and after altitude training, or in athletes performing altitude training in comparison with a control group were analyzed. Data of the populations, intervention, comparison, outcomes and study design were extracted. Review Manager software 5.3 was used for bias evaluation. Results: 17 publications were included. In our meta-analysis, altitude training led to higher maximum oxygen uptake [standardized mean difference (SMD) = 0.67, 95% confidence interval (CI) 0.35–1.00, P

This study was designed to validate an incremental test predicting maximum oxygen uptake for lifeguards. A maximum incremental test was performed in the laboratory (i.e., treadmill run) and in the pool (i.e., swim) by 10 certified lifeguards. The values of maximum oxygen uptake (VO2Max), maximum heart rate (HRMax), and lactate (LaMax) achieved during both tests were analyzed. The VO2Max (0.87, p =.001), HRmax (0.85, p = .002) and LaMax (0.67, p <.05) values showed significant correlations between the laboratory tests and the pool tests. These results showed that the Incremental Pool Test for Lifeguards (IPTL) was valid (i.e., concurrent validity) for obtaining the maximum oxygen uptake of a rescuer. Using this swim test, lifeguards and their supervisors will be able to individualize their training in order to improve their performance in a water rescue and perhaps reduce the numbers of fatal drownings. [ABSTRACT FROM AUTHOR]

The study purpose was to compare the effects of concurrent resistance and aerobic training to resistance and/or aerobic training alone on body composition, muscular strength and maximum oxygen uptake in overweight and obese men. Materials and methods. Twenty-four overweight and obese (BMI = 23.0 – 29.9 kg/m2) volunteers who were male students from Ubon Ratchathani Rajabhat University, aged 19-22 years were assigned into 3 groups: 1) resistance training group (RT), 2) aerobic training group (AT) and 3) concurrent resistance and aerobic training group (RT+AT). The training was 45 minutes per session and 2 days per week. Body composition along with muscular strength (1-RM) and maximum oxygen uptake (VO2max) were measured before (2-3 days prior) and after (2-3 days post) a 5-week training period. Results. Waist circumference was significantly decreased in all three groups, but the RT+AT group also found improvement in percentages of fat-free mass (0.49 ± 0.49%, p = 0.021, mean ± SD) and skeletal muscle mass (1.01 ± 0.95%, p = 0.025) when compared to their baseline. Similarly, 1-RM in leg extension was significantly increased in all three groups, while the RT group (47.67 ± 14.85%, p = 0.01) and the RT+AT group (42.08 ± 21.70%, p = 0.039) showed a substantially larger improvement in the 1-RM in leg extension when compared to the AT group (20.37 ± 13.97%). Finally, VO2max was significantly increased in all three groups (baseline to post-intervention), though they were not significantly different between groups. Conclusions. Concurrent resistance and aerobic training can reduce waist circumference and increase fat-free mass, skeletal muscle mass, 1-RM and VO2max. Therefore, this training strategy may serve as a useful alternative way to improve overall physical fitness and health promotion in overweight to obese male population.

This study aimed to develop prediction equations for maximum oxygen uptake (VO2max) based on non-exercise (anthropometric) and submaximal exercise (anthropometric and physiological) variables in paraplegic men with a spinal cord injury. All participants were tested on an arm ergometer using a maximal graded exercise test. Anthropometric variables such as age, height, weight, body fat, body mass index, body fat percentage, and arm muscle mass and physiological variables such as VO2, VCO2, and heart rate at 3 and 6 min of graded exercise tests were included in the multiple linear regression analysis. The prediction equations revealed the following. Regarding non-exercise variables, VO2max was correlated with age and weight (equation R = 0.771, R2 = 0.595, SEE= 3.187). Regarding submaximal variables, VO2max was correlated with weight and VO2 and VCO2 at 6 min (equation R = 0.892, R2 = 0.796, SEE = 2.309). In conclusion, our prediction equations can be used as a cardiopulmonary function evaluation tool to estimate VO2max simply and conveniently using the anthropometric and physiological characteristics of paraplegic men with spinal cord injuries. [ABSTRACT FROM AUTHOR]

This review sought to assess the dose-response, i.e., low (<300 mg/day) and high (>300 mg/day), and temporal effects of ginseng, i.e., immediate, short-term (up to 4 weeks) and long-term (>4 weeks) in comparison to placebo on physical performance [visual analogue scale (VAS) level, vertical jump(VJ), rating of perceived exertion (RPE), peak power output (PPO)] and physiological measures [VO2 max, creatine kinase(CK), heart rate(HR)], in athletes and active participants. Search in four databases with English language constraints yielded 492 studies. Fourteen studies were shortlisted through PEDro scale by methodological quality evaluation. Ginseng exhibited significant short-term effect at high dosage for VJ improvement (SMD: −8.17, 95% CI: −16.28 to −0.06, p= 0.05). Ginseng had no effect on VAS (SMD: −0.65, 95% CI: −1.35 to 0.06, p= 0.07), RPE (SMD: −1.11, 95% CI: −2.57 to 0.35, p= 0.14), PPO (SMD: −0.70, 95% CI: −1.78 to 0.38, p= 0.20), HR (SMD: −0.54, 95% CI: −2.05 to 0.96, p= 0.48), CK (SMD: 0.33, 95% CI: −0.18 to 0.84, p= 0.21) and VO2 max (SMD: 0.08, 95% CI: −0.69 to 0.85, p= 0.08).The ginseng supplementation was found to have significant short-term effect at high dose only for VJ in athletic and active participants. Methodologically strong research is warranted to further consolidate these findings. [ABSTRACT FROM AUTHOR]

Trekking is a popular activity associated with cardiovascular benefits. The aim of the present study was to investigate changes in the submaximal heart rate, oxygen uptake, oxygen pulse, and blood lactate concentration associated with a 6-day mountain walk. Over a 12-year period, 134 male (age 21.0 ± 1.4 years) and 124 female undergraduates (age 20.8 ± 1.6 years) participated. Three days before the trek submaximal and maximal laboratory measures were made on participants walking on a motorized treadmill using a breath-by-breath system to measure oxygen uptake (VO2) during exercise. Oxygen uptake and heart rate were recorded during steady-state exercise at treadmill gradients 0, 4, 8, 12, and 16%. Measurements were made, at the same time of day, two days after the trek. There were significant improvements in both the walking economy and the relative exercise intensity (%VO2max) at submaximal treadmill gradients 0-16%. Post-trek, heart rate was lower while oxygen pulse was higher, at each treadmill gradient. There was a significant increase in the maximal oxygen uptake for men (+2.7%) and women (+2.9%). The results of the present study suggest that improvements in cardiorespiratory fitness are associated with a 6-day mountain walk with no sex difference in the exercise response.. [ABSTRACT FROM AUTHOR]

BACKGROUND: Peak oxygen pulse can reflect the state of cardiovascular function. However, it needs to be measured in the subjects who are at a state of exhaustion using precision instruments under the guidance of professionals. OBJECTIVE: To establish a simple and easy method for evaluating cardiovascular function. METHODS: Totally 140 young people were randomly recruited and their height, body mass, body fat rate, resting heart rate, resting blood pressure, vital capacity, waist circumference, and hip circumference were measured. Each subject wore a gas metabolism analyzer to perform a cardiopulmonary exercise test on an ergometry. Peak oxygen pulse, maximum oxygen uptake, respiratory quotient, and peak heart rate when the subject reached the maximum performance capacity were collected, and the multiple linear regression method was used to establish the regression equation between peak oxygen pulse and body shape and cardiovascular function indicators. RESULTS AND CONCLUSION: The peak oxygen pulse equation was established: peak oxygen pulse (mL/beat)=37.287-3.062×sex+0.114×body mass-0.202×resting heart rate-0.063×systolic blood pressure. The peak oxygen pulse equation was verified to have good reliability by analysis of variance, goodness-of-fit test, Durbin-Watson test, and Shapiro-Wilk test. The back-substitution test indicated that the equation established in this study had good validity. There was no significant difference between the measured and predicted value of peak oxygen pulse, and the correlation reached 0.89. To conclude, the peak oxygen pulse equation using sex, body mass, resting heart rate, and systolic blood pressure was established in this study. [ABSTRACT FROM AUTHOR]

With regional hypoxic episodes in the world’s oceans becoming more severe and more frequent, a valuable management need will be a screening protocol to characterize the full diversity of hypoxic robustness among fishes (defined here as their tolerance and performance). Yet, high-throughput screening protocols to deal with the almost 33,000 fish species have the potential to trade off convenience with the information depth normally provided with comprehensive but more time-consuming phenotyping protocols. As a solution, we propose a two-tier testing approach, one that combines a simple, rapid, cost-effective, and well-established hypoxia challenge test (a measure of hypoxic tolerance) with an individual-based hypoxic performance test that defines maximum aerobic capacity over a wide range of ambient water oxygen levels (a hypoxic performance curve). The later test would be performed on selected indicator species identified from the tolerance screening test. Here we describe the two methodological approaches for this two-tier approach using some existing data to illustrate the potential for their applications in marine science.

OBJECTIVE: To conduct a Meta-analysis on the effects of endurance and strength training on maximum oxygen uptake (VO2 max), vertical jump and upper and lower limb strength (1RM) of different populations, so as to propose the optimal exercise intervention plan. METHODS: CNKI, PubMed, WanFang, and Web of Science were retrieved from their inception to October 2020. Review Manager 5.4 was used for analyzing the overall effect, heterogeneity, and publication bias using the fixed effect model and random effect model. Finally 15 foreign language documents involving 409 subjects were included and analyzed from different angles. RESULTS: Concurrent endurance and strength training could improve the maximum oxygen uptake, but was relatively inferior to the traditional endurance training. Concurrent endurance and strength training had no significant effect on the overall strength of the upper and lower limbs. The combined effect size of leg lift, leg flexion and extension, and squat and its 95% confidence interval were 8.47 [-3.95, 20.88], 2.46 [-11.34, 9.73], -0.81 [-2.72, 7.64] (P > 0.1). Concurrent endurance and strength training had certain but no significant effect on vertical jump (mean difference=0.44, 95% confidence interval [-0.97,1.85], P > 0.05). CONCLUSION: Concurrent endurance and strength training can improve the body’s maximum oxygen uptake. In sports training, compared with the traditional endurance or strength training alone, concurrent endurance and strength training can maintain the body strength level, while developing other basic qualities such as endurance. Therefore, concurrent endurance and strength training has better benefits for physical fitness compared with strength or endurance training alone. Moreover, concurrent endurance and strength training has less impact on explosive force and overall strength, which can achieve the best results based on an 8-12 week training cycle and 2-3 times per week. [ABSTRACT FROM AUTHOR]

Physical inactivity is documented as a health risk factor for chronic diseases, accelerated aging, and cognitive impairment. Physical exercise, on the other hand, plays an important role in healthy aging by promoting positive muscular, cardiovascular, and central nervous system adaptions. Prior studies on the effects of exercise training on cerebral perfusion have focused largely on elderly cohorts or patient cohorts, while perfusion effects of exercise training in young sedentary adults have not yet been fully assessed. Therefore, the present study examined the physiological consequence of a 6-month endurance exercise training on brain perfusion in 28 young sedentary adults randomly assigned to an intervention group (IG; regular physical exercise) or a control group (CG; without physical exercise). The IG performed an extensive running interval training three times per week over 6 months. Performance diagnostics and MRI were performed every 2 months, and training intensity was adapted individually. Brain perfusion measurements with pseudo-continuous arterial spin labeling were analyzed using the standard Oxford ASL pipeline. A significant interaction effect between group and time was found for right superior temporal gyrus (STG) perfusion, driven by an increase in the IG and a decrease in the CG. Furthermore, a significant time effect was observed in the right middle occipital region in the IG only. Perfusion increases in the right STG, in the ventral striatum, and in primary motor areas were significantly associated with increases in maximum oxygen uptake (VO2max). Overall, this study identified region-specific increases in local perfusion in a cohort of young adults that partly correlated with individual performance increases, hence, suggesting exercise dose dependency. Respective adaptations in brain perfusion are discussed in the context of physical exercise-induced vascular plasticity. [ABSTRACT FROM AUTHOR]

Physical inactivity is documented as a health risk factor for chronic diseases, accelerated aging, and cognitive impairment. Physical exercise, on the other hand, plays an important role in healthy aging by promoting positive muscular, cardiovascular, and central nervous system adaptions. Prior studies on the effects of exercise training on cerebral perfusion have focused largely on elderly cohorts or patient cohorts, while perfusion effects of exercise training in young sedentary adults have not yet been fully assessed. Therefore, the present study examined the physiological consequence of a 6-month endurance exercise training on brain perfusion in 28 young sedentary adults randomly assigned to an intervention group (IG; regular physical exercise) or a control group (CG; without physical exercise). The IG performed an extensive running interval training three times per week over 6 months. Performance diagnostics and MRI were performed every 2 months, and training intensity was adapted individually. Brain perfusion measurements with pseudo-continuous arterial spin labeling were analyzed using the standard Oxford ASL pipeline. A significant interaction effect between group and time was found for right superior temporal gyrus (STG) perfusion, driven by an increase in the IG and a decrease in the CG. Furthermore, a significant time effect was observed in the right middle occipital region in the IG only. Perfusion increases in the right STG, in the ventral striatum, and in primary motor areas were significantly associated with increases in maximum oxygen uptake (VO2max). Overall, this study identified region-specific increases in local perfusion in a cohort of young adults that partly correlated with individual performance increases, hence, suggesting exercise dose dependency. Respective adaptations in brain perfusion are discussed in the context of physical exercise-induced vascular plasticity.

Abstract Aims Maximum oxygen uptake (VO2max) is an essential parameter to assess functional capacity of patients with heart failure (HF). We aimed to identify clinical factors that determine its value, as they have not been well characterized yet. Methods We conducted a retrospective, observational, single‐centre study of 362 consecutive patients with HF who underwent cardiopulmonary exercise testing (CPET) as part of standard clinical assessment since 2009–2019. CPET was performed on treadmill, according to Bruce's protocol (n = 360) or Naughton's protocol (n = 2). We performed multivariable linear regression analyses in order to identify independent clinical predictors associated with peak VO2max. Results Mean age of study patients was 57.3 ± 10.9 years, mean left ventricular ejection fraction was 32.8 ± 14.2%, and mean VO2max was 19.8 ± 5.2 mL/kg/min. Eighty‐nine (24.6%) patients were women, and 114 (31.5%) had ischaemic heart disease. Multivariable linear regression analysis identified six independent clinical predictors of VO2max, including NYHA class (B coefficient = −2.585; P

Obesity induces several disorders, such as android obesity, insulin resistance, and coronary/peripheral artery disease, and obese individuals commonly have low adherence to training programs. Exercise at self-selected intensity is a feasible strategy to avoid dropouts of training routines. We aimed to assess the effects of different training programs at self-selected intensity on body composition, ratings of perceived exertion (RPE), feelings of pleasure and displeasure (FPD) and fitness outcomes (maximum oxygen uptake (VO2max) and maximum dynamic strength (1RM)) in obese women. Forty obese women (n = 40; Body Mass Index: 33.2 ± 1.1 kg.m-2) were randomly allocated to combined training (CT = 10), aerobic training (AT = 10), resistance training (RT = 10) and control group (CG = 10). The frequency that CT, AT and RT performed the training sessions was 3 times per week during 8 weeks. Body composition (DXA), VO2max and 1RM were assessed at baseline and after intervention. All participants were on a restricted dietary intake aiming to ingest 2.650 kcal per day. Post hoc comparisons revealed that CT promotes a larger decrease in body fat percentage (p = 0.001), body fat mass (p = 0.004) than other groups. CT and AT elicited higher V̇O2max increases (p = 0.014) than RT and CG, and 1RM values were higher in CT and RT (p = 0.001) than AT and CG at post-intervention. All training groups presented low RPE and high FPD over the training sessions, but only the CT was effective to reduce body fat percentage and body fat mass in obese women. In addition, CT was effective to increase simultaneously maximum oxygen uptake and maximum dynamic strength in obese women. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study was to assess the influence of physiological and kinematic predictors on 400-m front crawl race in young male swimmers and to consider the interrelation between them. Methods: Nineteen male swimmers took part in this study (age: 13.5 ± 0.44 years, height: 168.6 ± 7.77 cm, body mass: 56.9 ± 10.57 kg). Measurements of physiological parameters were conducted using expired air analyzer (Start 2000 MES, Poland) during step-test in water flume. Kinematic indices were computed while analyzing video recording of 400-m front crawl race. To check for possible influence of biological age (BA) diversity in studied group, partial correlation with age control was computed. Results: Swimming to exhaustion in water flume defined as speed at maximum oxygen uptake and anaerobic threshold (VO2 max V & and VAT) occurred to be strongly positively correlated with 400-m race speed. Speed in surface swimming zones (Vsurface) was related to ability of kinematics adjustment and significantly correlated with stroke index (SI). Vsurface at the beginning and the end of the race, i.e., at 1st, 7th and 8th lap interplayed with stroke rate (SR) measured at corresponding laps. Conclusions: Our study showed that 400-m front crawl performance of young male swimmers is strongly dependent on swimming efficiency developed with aerobic conditioning. Significant role of proper pacing strategy was also identified, which indicates that race pace training should be implemented. [ABSTRACT FROM AUTHOR]

Background: Several factors contributed to the evolution of handball, and one of the most important changes for faster, more dynamic and aggressive game is the change of rules which increase physical demands of players and especially referees. The aim of this study is to determine whether functional abilities have an influence on the quality of refereeing. Material and methods: 31 subjects were involved in the research, all of them top-level referees with an average age of 34.66±6.44, height 184.02±5.87 cm and body mass 91.14±10.61 kg. Testing was divided into two parts: the first part was spiroergometric progressive test on a treadmill to diagnose functional abilities, and the second part was the official handball matches. Results: Results show an average relative maximum oxygen uptake of 45.35±6.12 ml/min/kg. No statistically significant correlation was found between better functional abilities of handball referees and a better quality of refereeing. Conclusions: Referees have a lower anaerobic capacity, which could lead to errors in their judgment during the highest physiological loads in a match. Referees are a homogeneous group due to elimination criteria on tests at official seminars. If there were no elimination criteria, there would be greater variability among referees, and it would be possible to confirm the hypothesis that better functional abilities would lead to a better quality of refereeing.

Background: Multiples of resting metabolic rate (RMR) are often used to classify physical activity intensity, a concept known as the metabolic equivalent of task (MET). However, the METs metrics may misclassify physical activity intensity in older adults because of age-related changes in RMR and maximal aerobic capacity (V˙O2max). This study aimed to (i) compare classifications of activity intensity by estimated (METsestimated) and measured (METsmeasured) METs and (ii) compare physical activity classified by absolute (METsmeasured) versus relative intensity (%V˙O2Reserve) in older adults., Methods: Ninety-eight adults aged 75-90 years participated in the study. RMR and V˙O2 during sitting, standing, daily activities, and 6-minute walking test were measured. V˙O2Reserve was defined as the difference between V˙O2max and RMR. Moderate and vigorous intensity was classified as 3 and 6 METs and 40% and 60% of V˙O2Reserve, respectively. Paired t tests and a confusion matrix were used to investigate aims 1 and 2, respectively., Results: METsmeasured was 24% lower than the standard 1 MET of 3.5 mL O2·min-1·kg-1. METsestimated underestimated the intensity during daily and walking activities when compared to METsmeasured. Nevertheless, when comparing METsmeasured to percentages of V˙O2Reserve, a mismatch was shown for moderate intensity in 47%-67% of the participants during daily activities and 21% of the participants during self-selected gait speed., Conclusions: Applying METsestimated for older adults leads to potential underestimation of physical activity intensity, suggesting that current classification metrics should be revised for older adults. V˙O2Reserve is a candidate metric for establishing precise physical activity intensity cut points for older adults. Clinical Trials Registration Number: NCT04821713., (© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Purpose: Continuous incremental protocols (CP) may misestimate the maximum aerobic velocity (Vmax) due to increases in running speed faster than cardiorespiratory/metabolic adjustments. A higher aerobic capacity may mitigate this issue due to faster pulmonary oxygen uptake ( V ˙ O2) kinetics. Therefore, this study aimed to compare three different protocols to assess Vmax in athletes with higher or lower training status. Methods: Sixteen well-trained runners were classified according to higher (HI) or lower (LO) V ˙ O2max V ˙ O2-kinetics was calculated across four 5-min running bouts at 10 km·h−1. Two CPs [1 km·h−1 per min (CP1) and 1 km·h−1 every 2-min (CP2)] were performed to determine Vmax V ˙ O2max, lactate-threshold and submaximal V ˙ O2/velocity relationship. Results were compared to the discontinuous incremental protocol (DP). Results: Vmax, V ˙ O2max, V ˙ CO2 and VE were higher [(P < 0.05,(ES:0.22/2.59)] in HI than in LO. V ˙ O2-kinetics was faster [P < 0.05,(ES:-2.74/ − 1.76)] in HI than in LO. V ˙ O2/velocity slope was lower in HI than in LO [(P < 0.05,(ES:-1.63/ − 0.18)]. Vmax and V ˙ O2/velocity slope were CP1 > CP2 = DP for HI and CP1 > CP2 > DP for LO. A lower [P < 0.05,(ES:0.53/0.75)] Vmax-difference for both CP1 and CP2 vs DP was found in HI than in LO. Vmax-differences in CP1 vs DP showed a large inverse correlation with Vmax, V ˙ O2max and lactate-threshold and a very large correlation with V ˙ O2-kinetics. Conclusions: Higher aerobic training status witnessed by faster V ˙ O2 kinetics led to lower between-protocol Vmax differences, particularly between CP2 vs DP. Faster kinetics may minimize the mismatch issues between metabolic and mechanical power that may occur in CP. This should be considered for exercise prescription at different percentages of Vmax. [ABSTRACT FROM AUTHOR]

The study was conducted to compare peak oxygen uptake (VO2peak) measured with the incremental graded test (GXT) (VO2peak) and two tests to verify maximum oxygen uptake, performed 15 min after the incremental test (VO2peak1) and on a separate day (VO2peak2). The aim was to determine which of the verification tests is more accurate and, more generally, to validate the VO2max obtained in the incremental graded test on cycle ergometer. The study involved 23 participants with varying levels of physical activity. Analysis of variance showed no statistically significant differences for repeated measurements (F = 2.28, p = 0.118, η2 = 0.12). Bland–Altman analysis revealed a small bias of the VO2peak1 results compared to the VO2peak (0.4 ml⋅min–1⋅kg–1) and VO2peak2 results compared to the VO2peak (−0.76 ml⋅min–1⋅kg–1). In isolated cases, it was observed that VO2peak1 and VO2peak2 differed by more than 5% from VO2peak. Considering the above, it can be stated that among young people, there are no statistically significant differences between the values of VO2peak measured in the following tests. However, in individual cases, the need to verify the maximum oxygen uptake is stated, but performing a second verification test on a separate day has no additional benefit. [ABSTRACT FROM AUTHOR]

It is known that cardiovascular risk is increased during exercise and recovery. Thus, it is necessary to assess all the risk associated with exercise to minimize chances of cardiovascular events. The aim of this study was to verify whether a maximal exercise alters ambulatory cardiac autonomic modulation in untrained women and whether aerobic fitness is correlated to cardiac autonomic modulation. Twelve women (25.35 ± 5.44 years) were outfitted with the Holter monitor on an experimental (after maximum exercise) and a control day to heart rate variability (HRV) evaluation. Maximal exercise increased 24 h heart rate (82 ± 14 vs 77 ± 11 bpm; p = 0.04) and during sleep time (72 ± 14 vs. 65 ± 9 bpm; p = 0.01), reduced parasympathetic modulation (HF – n.u. 49.96 ± 11.56 vs 42.10 ± 14.98; p = 0.04), and increased low-frequency/high-frequency ratio (2.88 ± 3.24 vs 1.31 ± 0.60; p = 0.03) during sleep time compared to the control day. Aerobic fitness was correlated positively with LF, HF, and HF (n.u.) indices (r = 0.61 to 0.73, p < 0.05) and correlated negatively with LF (n.u.) and LF/HF ratio (Rho = - 0.57 to - 0.69; p < 0.05). Maximal exercise alters parasympathetic modulation during sleep time in untrained women. Ambulatory cardiac autonomic modulation after exercise is related to aerobic fitness.

The study was conducted to compare peak oxygen uptake (VO2peak) measured with the incremental graded test (GXT) (VO2peak) and two tests to verify maximum oxygen uptake, performed 15 min after the incremental test (VO2peak1) and on a separate day (VO2peak2). The aim was to determine which of the verification tests is more accurate and, more generally, to validate the VO2max obtained in the incremental graded test on cycle ergometer. The study involved 23 participants with varying levels of physical activity. Analysis of variance showed no statistically significant differences for repeated measurements (F = 2.28, p = 0.118, η2 = 0.12). Bland–Altman analysis revealed a small bias of the VO2peak1 results compared to the VO2peak (0.4 ml⋅min–1⋅kg–1) and VO2peak2 results compared to the VO2peak (−0.76 ml⋅min–1⋅kg–1). In isolated cases, it was observed that VO2peak1 and VO2peak2 differed by more than 5% from VO2peak. Considering the above, it can be stated that among young people, there are no statistically significant differences between the values of VO2peak measured in the following tests. However, in individual cases, the need to verify the maximum oxygen uptake is stated, but performing a second verification test on a separate day has no additional benefit.

Background: Maximum oxygen uptake (VO2max) is an important respiratory physiological index of the aerobic endurance of the body, especially for special groups such as drug addicts, and it is an important indicator for assessing the cardiopulmonary function and formulating exercise prescriptions. Although the cardiopulmonary exercise test (CPX) is a classic method to directly measure VO2max, this method is limited by factors such as cumbersome operating procedures and expensive equipment, resulting in its relatively low applicability. Recently, many studies have begun to focus on the estimation of VO2max in different groups of people, but few studies have focused on drug addicts.Methods: Fifteen chemically synthesized drug addicts (such as amphetamines) and Fifteen plant-derived drug addicts (such as heroin) were recruited at the Chongqing Compulsory Isolation and Drug Rehabilitation Center in China. First, the VO2max of subjects was directly measured through the CPX. Second, after subjects were fully rested, they were required to complete the 30-s high-leg raise, 1,000-m walk, and 3-min step experiment. Finally, SPSS 21.0 software was used to perform the correlation and linear regression analysis to verify the estimated effectiveness.Results: (1) Regardless of chemically synthesized or natural plant-derived drug addicts, the years of drug use and walking time of 1,000 m were significantly negatively correlated with VO2max (chemically synthesized: P < 0.01 and natural plant-derived: P < 0.05), the number of 30-s high-leg raises was a significantly positive correlation with VO2max (P < 0.05 and P < 0.01), and the 3-min step index was significantly positively correlated with VO2max (P < 0.01 and P < 0.01). (2) Regression analysis shows that the 30-s high-leg lift, 1,000-m walking, and 3-min step experiment could effectively estimate the VO2max of chemically synthesized and natural plant-derived drug addicts. (3) Multiple linear regression constructed by the years of drug use combined with the step index has the highest estimated accuracy for the VO2max of chemically synthesized drug addicts (96.48%), while the unary regression equation established by a single step index has the highest prediction accuracy for the VO2max of natural plant-derived addicts (94.30%).Conclusion: The indirect measurement method could effectively estimate the VO2max of drug addicts, but different measurement methods have certain differences in the estimation accuracy of VO2max of different drug addicts. In the future, the physical characteristics of drug users can be fully considered, combined with more cutting-edge science and technology, to make the estimation accuracy of VO2max closer to the real level.

Background: Maximum oxygen uptake (VO2max) is an important respiratory physiological index of the aerobic endurance of the body, especially for special groups such as drug addicts, and it is an important indicator for assessing the cardiopulmonary function and formulating exercise prescriptions. Although the cardiopulmonary exercise test (CPX) is a classic method to directly measure VO2max, this method is limited by factors such as cumbersome operating procedures and expensive equipment, resulting in its relatively low applicability. Recently, many studies have begun to focus on the estimation of VO2max in different groups of people, but few studies have focused on drug addicts. Methods: Fifteen chemically synthesized drug addicts (such as amphetamines) and Fifteen plant-derived drug addicts (such as heroin) were recruited at the Chongqing Compulsory Isolation and Drug Rehabilitation Center in China. First, the VO2max of subjects was directly measured through the CPX. Second, after subjects were fully rested, they were required to complete the 30-s high-leg raise, 1,000-m walk, and 3-min step experiment. Finally, SPSS 21.0 software was used to perform the correlation and linear regression analysis to verify the estimated effectiveness. Results: (1) Regardless of chemically synthesized or natural plant-derived drug addicts, the years of drug use and walking time of 1,000 m were significantly negatively correlated with VO2max (chemically synthesized: P < 0.01 and natural plant-derived: P < 0.05), the number of 30-s high-leg raises was a significantly positive correlation with VO2max (P < 0.05 and P < 0.01), and the 3-min step index was significantly positively correlated with VO2max (P < 0.01 and P < 0.01). (2) Regression analysis shows that the 30-s high-leg lift, 1,000-m walking, and 3-min step experiment could effectively estimate the VO2max of chemically synthesized and natural plant-derived drug addicts. (3) Multiple linear regression constructed by the years of drug use combined with the step index has the highest estimated accuracy for the VO2max of chemically synthesized drug addicts (96.48%), while the unary regression equation established by a single step index has the highest prediction accuracy for the VO2max of natural plant-derived addicts (94.30%). Conclusion: The indirect measurement method could effectively estimate the VO2max of drug addicts, but different measurement methods have certain differences in the estimation accuracy of VO2max of different drug addicts. In the future, the physical characteristics of drug users can be fully considered, combined with more cutting-edge science and technology, to make the estimation accuracy of VO2max closer to the real level. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the safety and feasibility of performing treadmill aerobic exercise in moderate normobaric hypoxia among chronic hemiparetic stroke survivors. Design: Observational study using convenience sampling. Setting: Research laboratory in a tertiary rehabilitation hospital. Participants: Chronic hemiparetic stroke survivors who could walk at least 10-m with or without assistance and had no absolute contraindications to exercise testing. Intervention: Participants (three male and four female) were asked to complete three normobaric hypoxia exposure protocols within a single session. First, they were passively exposed to normobaric hypoxia through gradual reductions in the fraction of inspired oxygen (FIO2 = 20.9, 17.0, and 15.0%) while seated (5-min at each level of FIO2). Participants were then exposed to the same reductions in FIO2 during constant-load exercise performed on a treadmill at 40% of heart rate reserve. Finally, participants completed 20-min of exercise while intermittently exposed to moderate normobaric hypoxia (5 × 2-min at FIO2 = 15.0%) interspaced with 2-min normoxia intervals (FIO2 = 20.9%). Outcome Measures: The primary outcome was occurrence of adverse events, which included standardized criteria for terminating exercise testing, blood oxygen saturation (S p O2) <80%, or acute mountain sickness score >2. The increased cardiovascular strain imposed by normobaric hypoxia exposure at rest and during exercise was evaluated by changes in S p O2, heart rate (HR), blood pressure, and rating of perceived exertion (RPE). Results: One participant reported mild symptoms of nausea during exercise in normobaric hypoxia and discontinued participation. No other adverse events were recorded. Intermittent normobaric hypoxia exposure was associated with reduced S p O2 (MD = −7.4%, CI: −9.8 to −5.0) and increased HR (MD = 8.2, CI: 4.6 to 11.7) compared to intervals while breathing typical room air throughout the 20-min constant-load exercise period. The increase in HR was associated with a 10% increase in relative effort. However, reducing FIO2 had little effect on blood pressure and RPE measurements. Conclusion: Moderate normobaric hypoxia appeared to be a safe and feasible method to increase the cardiovascular strain of submaximal exercise in chronic hemiparetic stroke survivors. Future studies evaluating the effects of pairing normobaric hypoxia exposure with existing therapies on secondary prevention and functional recovery are warranted. [ABSTRACT FROM AUTHOR]

Introduction. Respiratory function is subject to the aging process, similarly to that of multiple other systems. Regular aquatic exercise favors physical development, and improves circulation and respiration, as well as overall health. Aim of Study. The purpose of the study was to assess the impact of a 12-week training program involving water aerobics on respiratory system function and aerobic capacity in post-menopausal women. Material and Methods. The study included 30 women (21 in the study group, 9 controls). Women in the study group participated in supervised water aerobics classes, twice a week for 3 months. At the beginning and end of the study, all the women underwent a spirometry test and an exercise test by an ergometer. Results. An analysis of changes after the training program demonstrated a significant increase of the maximal aerobic capacity in the study group (p < 0.05). No significant changes were found in spirometry indicators (VC) or airflow parameters in the large and small airways (MEF75, MEF50) following a 12-week water aerobics program. Conclusions. The implemented training program for healthy postmenopausal women did not improve the spirometry indicators studied, and the observed aerobic capacity increase likely resulted from improved circulatory and metabolic performance that determines an individual's exercise tolerance and health. [ABSTRACT FROM AUTHOR]

PurposeThe lactate threshold (LT), critical power (CP) and maximum oxygen uptake (VO₂max) together partition exercise intensity domains by their common physiological, biochemical and perceptual response characteristics. CP is the greatest power output attainable immediately following intolerance at VO₂peak, and the asymptote of 3 min all-out exercise. Thus we reasoned that a maximal 'sprint' immediately following standard ramp-incremental exercise would allow characterisation of the three aerobic indices in a single test.MethodsTen healthy men (23 ± 3 year, mean ± SD) performed 9 cycle-ergometry tests on different days: (A) two ramp-incremental tests to intolerance (20 W min(-1)), immediately followed by a 3 min maximal, variable-power effort ramp-sprint test (RST) for LT, VO₂peak and sprint-phase power (SP) determination; (B) four constant-power tests for CP and VO₂max determination; (C) constant-power tests at 10 W below LT, and 10 W below and above SP to verify intensity domain characterisation. Capillary [lactate] and breath-by-breath VO₂ were measured.ResultsReproducibility of LT, SP and VO₂max measurements between RST repeats was within 5% or less (r ≥ 0.991, p < 0.001). CP (257 ± 46 W) was not different (p = 0.72) from SP (258 ± 42 W). Exercise 10 W below LT and SP resulted in steady state VO₂ and [lactate]. VO₂max (4.0 ± 0.6 L min(-1)), peak [lactate] (11 ± 2 mM) and intolerance were reached 19 ± 5 min into exercise at 10 W above SP.ConclusionsThese data suggest that the key indices of aerobic function may be accurately and reliably estimated during a single exercise test. This test may provide a basis for simplifying assessment and prescription of exercise training and experimental interventions.

In this study five different knitted sport clothes were tested in a wear trial test with ten men subject. After the activity, subjects were included in a rest period of 20 minutes. In this period, microclimate temperature and relative humidity values were measured with a datalogger from four body regions (chest, abdomen, back and waist). The results showed that the lowest waist microclimate temperature value was seen in TS tencel single jersey fabric like the other three body regions. On the contrary to chest and back regions, the abdomen microclimate temperature values increase during the relaxing period. Also the lowest microclimate temperature values were seen in abdomen region. On the other hand the highest microclimate relative humidity values were seen in abdomen region ( 93-96 %).

Background: Currently, there are two methods for testing maximal oxygen uptake: the direct and indirect methods, but both have certain requirements for testing equipment, site, and personnel. There is a lack of a convenient and effective method for testing maximum oxygen uptake (VO2max). With the development of artificial neural network (ANN), a solution to this gap is provided. Objective: The goal of this study was to design a method to evaluate the cardiopulmonary function of young people and verify its feasibility and reliability. Methods: The incremental squat test (IST) and Young Men’s Christian Association (YMCA) test were designed with 196 subjects (97 males and 99 females). The back propagation (BP) neural network was used to construct the model of VO2max by recording and analyzing squatting times, height, weight, gender, age, leg length, Manou Riers Skelic index (MRSI), and VO2max. Results: Three hidden layers and 65 nodes were employed in the BP neural network. Each hidden layer contained 19 nodes. Other parameters of this network were 0.01, 0.9, and 2000 for the learning rate, momentum, and iterations, respectively. The difference between the measurements and predictions was not significant (p > 0.05), and the correlation between them was extremely strong (r = 0.98, p < 0.01). Conclusions: We conclude that the model constructed using the BP neural network is accurate, and the IST is feasible for predicting VO2max. This method can be used as a substitute for other cardiopulmonary fitness test protocols in cases of insufficient venues and equipment. thereby preventing health complications. In subsequent studies, the sample size should be expanded, and separate prediction models should be developed for different genders.

Purpose: The magnitude of heat acclimation (HA) adaptations varies largely among individuals, but it remains unclear what factors influence this variability. This study compared individual characteristics related to fitness status and body dimensions of low-, medium-, and high responders to HA.Methods: Twenty-four participants (9 female, 15 male; maximum oxygen uptake [[Formula: see text]O2peak,kg] 52 ± 9 mL kg-1 min-1) completed 10 daily controlled-hyperthermia HA sessions. Adaptations were evaluated by heat stress tests (HST; 35 min cycling 1.5 W  kg-1; 33 °C, 65% relative humidity) pre- and post-HA. Low-, medium-, and high responder groups were determined based on tertiles (n = 8) of individual adaptations for resting rectal temperature (Tre), exercise-induced Tre rise (ΔTre), whole-body sweat rate (WBSR), and heart rate (HR).Results: Body dimensions (p > 0.3) and [Formula: see text]O2peak,kg (p > 0.052) did not differentiate low-, medium-, and high responders for resting Tre or ΔTre. High WBSR responders had a larger body mass and lower body surface area-to-mass ratio than low responders (83.0 ± 9.3 vs 67.5 ± 7.3 kg; 249 ± 12 vs 274 ± 15 cm2 kg-1, respectively; p < 0.005). Conversely, high HR responders had a smaller body mass than low responders (69.2 ± 6.8 vs 83.4 ± 9.4 kg; p = 0.02). [Formula: see text]O2peak,kg did not differ among levels of responsiveness for WBSR and HR (p > 0.3).Conclusion: Individual body dimensions influenced the magnitude of sudomotor and cardiovascular adaptive responses, but did not differentiate Tre adaptations to HA. The influence of [Formula: see text]O2peak,kg on the magnitude of adaptations was limited. [ABSTRACT FROM AUTHOR]

Aims: Maximum oxygen uptake (VO2max) is an essential parameter to assess functional capacity of patients with heart failure (HF). We aimed to identify clinical factors that determine its value, as they have not been well characterized yet. Methods: We conducted a retrospective, observational, single‐centre study of 362 consecutive patients with HF who underwent cardiopulmonary exercise testing (CPET) as part of standard clinical assessment since 2009–2019. CPET was performed on treadmill, according to Bruce's protocol (n = 360) or Naughton's protocol (n = 2). We performed multivariable linear regression analyses in order to identify independent clinical predictors associated with peak VO2max. Results: Mean age of study patients was 57.3 ± 10.9 years, mean left ventricular ejection fraction was 32.8 ± 14.2%, and mean VO2max was 19.8 ± 5.2 mL/kg/min. Eighty‐nine (24.6%) patients were women, and 114 (31.5%) had ischaemic heart disease. Multivariable linear regression analysis identified six independent clinical predictors of VO2max, including NYHA class (B coefficient = −2.585; P < 0.001), age (B coefficient per 1 year = −0.104; P < 0.001), tricuspid annulus plane systolic excursion (B coefficient per 1 mm = +0.209; P < 0.001), body mass index (B coefficient per 1 kg/m2 = −0.172; P = 0.002), haemoglobin (B coefficient per 1 g/dL = +0.418; P = 0.007) and NT‐proBNP (B coefficient per 1000 pg/mL = −0.142; P = 0.019). Conclusions: The severity of HF (NYHA class, NT‐proBNP) as well as age, body composition and haemoglobin levels influence significantly exercise capacity. In patients with HF, the right ventricular systolic function is of greater importance for the physical capacity than the left ventricular systolic function. [ABSTRACT FROM AUTHOR]

Purpose: To quantify VO2max among female competitive soccer players as a function of performance level, field position, and age. In addition, the evolution of VO2max among world-class players over an 18-y period was quantified. Methods: Female players (N = 199, 22 ± 4 y, 63 ± 6 kg, height 169 ± 6 cm), including an Olympic winning squad, were tested for VO2max at the Norwegian Olympic Training Center between 1989 and 2007. Results: National-team players had 5% higher VO2max than 1st-division players (P = .042, d = 0.4), 13% higher than 2nd-division players (P < .001, d = 1.2), and 9% higher than junior players (P = .005, d = 1.0). Midfielders had 8% higher VO2max than goalkeepers (P = .048, d = 1.1). No significant differences were observed across outfield players or different age categories. There was a trend toward lower relative VO2max across time epochs. Conclusions: This study demonstrated that VO2max varies across playing-standard level in women's soccer. No significant differences in VO2max were observed across outfield positions and age categories. Over time, there has been a slight negative development in VO2max among elite Norwegian soccer players. [ABSTRACT FROM AUTHOR]

This study aimed to find out the differences in body composition, chemical indicators and maximum oxygen uptake measurements for runners and long distance swimmers. The sample of the study consisted of (20) players, (10 runners) and (10 swimmers), age ranged between (18-25) years. Athletes were selected from al-Yarmouk University. The measurements of this study included (height, weight, body mass index (the skinfold of behind humerus, trciptal, suprailiac, chest, subscapular, thigh, and leg) and circumference of chest, thigh, leg, humerus, arm, wrist. Chemical measurements were red blood cells, white blood cells, platelets, cholesterol, hemoglobin, hematocrit, glucose, thyroid hormones (T3, T4, TSH) and maximum oxygen uptake which has been measured through balke and storer test. The results indicated significant differences for thigh and wrist circumference, some chemical vairables (Hematocrit (HCT), hemoglobin (HGB), (LDL), and red blood cells (RBC), suprailiac, subscapular skin fold, thigh skinfold). However, the results did not indicatany significant deferences of the other chemical and physical measurements. The researchers recommended that the benefits of this study can be applied for the preparation of similar studies. [ABSTRACT FROM AUTHOR]

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Background: Physical exertion during exercise often leads to increased oxidative stress and inflammatory responses, significantly affecting physical performance. Current strategies to mitigate these effects are limited by their effectiveness and potential side effects. Molecular hydrogen (H₂) has gained attention for its antioxidant and anti-inflammatory properties. Studies have suggested that H 2 supplementation contributes to antioxidant potential and anti-fatigue during exercise, but the variance in the observations and study protocols is presented across those studies., Objective: This systematic review and meta-analysis aimed to comprehensively characterize the effects of H₂ supplementation on physical performance (i.e., endurance, muscular strength, and explosive power), providing knowledge that can inform strategies using H 2 for enhancing physical performance., Methods: We conducted a literature search of six databases (PubMed, Web of Science, Medline, Sport-Discus, Embase, and PsycINFO) according to the PRISMA guidelines. The data were extracted from the included studies and converted into the standardized mean difference (SMD). After that, we performed random-effects meta-analyses and used the I 2 statistic to evaluate heterogeneity. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to assess the quality of the evidence obtained from this meta-analysis., Results: In total, 27 publications consisting of 597 participants were included. The search finally included aerobic endurance, anaerobic endurance, muscular strength, lower limb explosive power, rating of perceived exertion (RPE), blood lactate (BLA), and average heart rate (HR avg ) in the effect size (ES) synthesis. The ES of H 2 on aerobic endurance, including V̇O 2max (SMD = 0.09, p  = 0.394; I 2 = 0%) and aerobic endurance exercise (SMD = 0.04, p  = 0.687; I 2 = 0%), were not significant and trivial; the ES of H 2 on 30 s maximal anaerobic endurance (SMD = 0.19, p  = 0.239; I 2 = 0%) was not significant and trivial; the ES of H 2 on muscular strength (SMD = 0.19, p  = 0.265; I 2 = 0%) was not significant and trivial; but the ES of H 2 on lower limb explosive power (SMD = 0.30, p  = 0.018; I 2 = 0%) was significant and small. In addition, H 2 reduces RPE (SMD = -0.37, p  = 0.009; I 2 = 58.0%) and BLA (SMD = -0.37, p  = 0.001; I 2 = 22.0%) during exercise, but not HR avg (SMD = -0.27, p  = 0.094; I 2 = 0%)., Conclusion: These findings suggest that H 2 supplementation is favorable in healthy adults to improve lower limb explosive power, alleviate fatigue, and boost BLA clearance, but may not be effectively improving aerobic and anaerobic endurance and muscular strength. Future studies with more rigorous designs are thus needed to examine and confirm the effects of H 2 on these important functionalities in humans., Systematic Review Registration: http://www.crd.york.ac.uk/PROSPERO., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Zhou, Shang, Yuan, Guo, Wang, Bao and Zhou.)

[Purpose] In Japan, one measure against the novel coronavirus disease-2019 infection involves the public use of surgical masks. Research indicates that exercising while wearing a mask increases the physical burden, particularly affecting young people during high-intensity exercise. This study examined the effects of wearing masks while running in male university students. [Participants and Methods] The participants were 20 healthy male university students (21.6 ± 1.6 years). The participants underwent cardiopulmonary exercise tests with the masks on and off on different days until exhaustion. The following parameters were measured: exercise duration, Borg Scale rating (respiratory or lower extremities), surface temperature around the mouth, time to sweat onset, metabolic reaction, pulmonary ventilation, and cardiovascular reaction parameters. [Results] The results showed that VO 2 max remained consistent between the mask-on and mask-off conditions. However, minute ventilation, respiratory rate, and heart rate decreased in the mask-on condition, which correlated with a reduction in exercise duration. Furthermore, running with the mask significantly decreased the VE/VO 2 , VE/ VO 2 , Borg Scale rating of the lower extremities, and the time to sweat onset. [Conclusion] Running with a surgical mask affected respiratory function and decreased exercise duration in healthy male university students. However, it did not induce any changes in VO 2 max., Competing Interests: The authors declare no conflict of interest., (2024©by the Society of Physical Therapy Science. Published by IPEC Inc.)

Purpose: This study examined parameters derived from both an incremental step-wise and a ramp-wise graded rowing exercise test in relation to rowing performance. Methods: Discontinuous step-wise incremental rowing to exhaustion established lactate threshold (LT), maximum oxygen consumption (VO2maxSTEP) and power associated with VO2max (W VO2max)- A further continuous ramp-wise test was undertaken to derive ventilatory threshold (VT), maximum oxygen consumption (VO2maxRAMP)> and maximum minute power (MMW). Results were compared with maximal 2000-m ergometer time-trial power. Results: The strongest correlation with 2000-m power was observed for MMW (r = .98, P < .001), followed by W VO2max (r = .96; P < .001). The difference between MMW and W VO2max compared with the mean of MMW/W VO2max showed a widening bias with a greater difference coincident with greater power. However, this bias was reduced when expressed as a ratio term and when a baseline VO2 was accounted for. There were no differences (P = .85) between measures of VO2maxSTEP an2maxRAMP; rather, the measures showed strong association (r = .97, P < .001, limits of agreement = -0.43 to 0.33 L/min). The power at LT and VT did not differ (P = .6), and a significant association was observed (r= .73, P= .001, limits of agreement = -54.3 to 20.2 W, SEE = 26.1 ). Conclusions: This study indicates that MMW demonstrates a strong association with ergometer rowing performance and thus may have potential as an influential monitoring tool for rowing athletes. [ABSTRACT FROM AUTHOR]