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The article presents the testing experience of the practical training of research master students in the integrative module of basic professional educational program of “Cultural-Historical Psychology and Activity Approach in Education”, training direction of “Psycho-pedagogical education”. We reviewed the organization of the practical training, its object and purpose, formed competence and educational outcomes, the content and form of organization of activity of students that achieve these results; assessment tools. We discussed the place of introductive training in the structure of integrative module as well as possible risks.

Complex lithium metallates Li MeZrO ( Me = Nb, Ti, x = 0.05, 0.1) with iso-and heterovalent substitutions for Zr ions in lithium zirconate are synthesized for the first time using a citrate technique. The inclusion of Ti and Nb ions in the crystal structure of LiZrO is confirmed by means of X-ray diffraction and NMR. It is shown that in the temperature range of 750-820 K, LiTiZrO solid solution has higher conductivity than phases of undoped lithium zirconate. [ABSTRACT FROM AUTHOR]

An unusual metabolite was detected in the urine of two children with neurological dysfunctions of unclear aetiology by using gas chromatography/mass spectrometry (GC/MS). On the basis of the analysis of its fragmentation pathways, synthesis of tentative compound and its GC/MS analysis it was stated that the unknown metabolite is 4-methoxybenzoyl-N-glycine.

In order to develop an approach to the study of cell metabolism in vitro, we undertook the determination of metabolites excreted by human skin diploid fibroblasts into culture medium using high-resolution gas chromatography in combination with mass spectrometry. Chromatographic and mass spectrometric characteristics of 29 metabolites have been obtained, and 11 of the metabolites have been identified. The excreted metabolites reflect the activity of certain metabolic processes in fibroblasts in vitro. A comparison of chromatographic and mass spectrometric characteristics of the cell metabolites and of those excreted from the body in urine showed most of the metabolites excreted by fibroblasts to be different from the urine metabolites. The possibility of secondary conversion of cell metabolites in the organism and the specificity of metabolism in cells of different tissues are discussed.

In order to study metabolic distinctions in phenylketonuria, urinary metabolites in the form of trimethylsilyl derivatives have been characterized by high resolution gas chromatography and mass spectrometry. A previously unknown metabolite has been found in the urine of some untreated phenylketonuric infants between 2 and 5 yr of age. The metabolite was absent in healthy children of the same age. The metabolite appeared to be present in the urine of apparently healthy adults (25-32 yr old). The metabolite was identified as methoxyacetylcarbamide on the basis of mass fragmentation analysis and compared with synthetic methoxyacetylcarbamide. Their retention times and mass spectra coincided.