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314 results on '"Maus, Uwe"'

2. Preventing long-term disability in CIDP: the role of timely diagnosis and treatment monitoring in a multicenter CIDP cohort

Author

Quint, Paula, Schroeter, Christina B., Kohle, Felix, Öztürk, Menekse, Meisel, Andreas, Tamburrino, Giuliano, Mausberg, Anne K., Szepanowski, Fabian, Afzali, Ali Maisam, Fischer, Katinka, Nelke, Christopher, Räuber, Saskia, Voth, Jan, Masanneck, Lars, Willison, Alice, Vogelsang, Anna, Hemmer, Bernhard, Berthele, Achim, Schroeter, Michael, Hartung, Hans-Peter, Pawlitzki, Marc, Schreiber, Stefanie, Stettner, Mark, Maus, Uwe, Meuth, Sven G., Stascheit, Frauke, and Ruck, Tobias

Published
2024
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17. Overlapping Stromal Alterations in Myeloid and Lymphoid Neoplasms.

Author

Bogun, Lucienne, Koch, Annemarie, Scherer, Bo, Germing, Ulrich, Fenk, Roland, Maus, Uwe, Bormann, Felix, Köhrer, Karl, Petzsch, Patrick, Wachtmeister, Thorsten, Kobbe, Guido, Dietrich, Sascha, Haas, Rainer, Schroeder, Thomas, Geyh, Stefanie, and Jäger, Paul

Subjects
RNA analysis, LYMPHOMA risk factors, MYELODYSPLASTIC syndromes, NON-Hodgkin's lymphoma, BONE marrow, RESEARCH funding, BONE marrow cancer, MYELOPROLIFERATIVE neoplasms, CELLULAR signal transduction, DESCRIPTIVE statistics, HEMATOPOIESIS, GENE expression, STROMAL cells, MYELOID leukemia, HEMATOPOIETIC stem cells, LYMPHOBLASTIC leukemia, CELL differentiation, DISEASE progression, SEQUENCE analysis
Abstract

Simple Summary: Simple Summary: Myeloid and lymphoid malignant cells can become the dominant population in the bone marrow and thus inhibit healthy hematopoiesis. Patients suffer enormously as a result. In addition to the directly mediated inhibition of healthy hematopoietic stem and progenitor cells, indirect mechanisms via so-called mesenchymal stromal cells can also play a role. We are focusing our research on the latter and would like to identify functional and molecular overlapping mechanisms within the various myeloid and lymphoid neoplasms. In the future, it may be possible to block these mechanisms and thus prevent disease progression or improve healthy hematopoiesis. Myeloid and lymphoid neoplasms share the characteristics of potential bone marrow infiltration as a primary or secondary effect, which readily leads to hematopoietic insufficiency. The mechanisms by which clonal malignant cells inhibit normal hematopoietic stem and progenitor cells (HSPCs) in the bone marrow (BM) have not been unraveled so far. Given the pivotal role of mesenchymal stromal cells (MSCs) in the regulation of hematopoiesis in the BM niche it is assumed that MSCs also play a relevant role in the pathogenesis of hematological neoplasms. We aimed to identify overlapping mechanisms in MSCs derived from myeloid and lymphoid neoplasms contributing to disease progression and suppression of HSPCs to develop interventions that target these mechanisms. MSCs derived from healthy donors (n = 44) and patients diagnosed with myeloproliferative neoplasia (n = 11), myelodysplastic syndromes (n = 16), or acute myeloid leukemia (n = 25) and B-Non-Hodgkin lymphoma (n = 9) with BM infiltration and acute lymphoblastic leukemia (n = 9) were analyzed for their functionality and by RNA sequencing. A reduced growth and differentiation capacity of MSCs was found in all entities. RNA sequencing distinguished both groups but clearly showed overlapping differentially expressed genes, including major players in the BMP/TGF and WNT-signaling pathway which are crucial for growth, osteogenesis, and hematopoiesis. Functional alterations in healthy MSCs were inducible by exposure to supernatants from malignant cells, implicating the involvement of these factors in disease progression. Overall, we were able to identify overlapping factors that pose potential future therapeutic targets. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Stromal alterations in patients with MGUS, smoldering myeloma and multiple myeloma

Author

Bogun, Lucienne, primary, Koch, Annemarie, additional, Scherer, Bo, additional, Fenk, Roland, additional, Maus, Uwe, additional, Bormann, Felix, additional, Köhrer, Karl, additional, Petzsch, Patrick, additional, Wachtmeister, Thorsten, additional, Zukovs, Romans, additional, Dietrich, Sascha, additional, Haas, Rainer, additional, Schroeder, Thomas, additional, Jäger, Paul Sebastian, additional, and Geyh, Stefanie, additional

Published
2024
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21. Kleinwuchs

Author

Maus, Uwe Martin, Vetter, Thomas, Semler, J. Oliver, Hofmann, Christine, Peters, Klaus M., Roth, Andreas, Sachse, André, Peters, Klaus M., editor, König, Dietmar Pierre, editor, and Roth, Andreas, editor

Published
2018
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22. Verkalkungen und Ossifikationen

Author

Maus, Uwe Martin, König, Dietmar Pierre, Arbab, Dariusch, Magosch, Petra, Peters, Klaus M., editor, König, Dietmar Pierre, editor, and Roth, Andreas, editor

Published
2018
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43. List of Contributors

Author

Abdalla, Beatrice Martinez Zugaib, primary, Albaugh, Vance L., additional, Ambrosano, Letícia, additional, Barbul, Adrian, additional, Bartsch, Silke, additional, Bonetti, Francesco, additional, Brombach, Christine, additional, Brombo, Gloria, additional, Casebolt, Jeffrey B., additional, Castonguay, Thomas W., additional, Chapman, Ian, additional, Chen, Chiao-nan, additional, Chen, Jianshe, additional, Clor, Jake Alexander, additional, Cook-Mills, Joan M., additional, Costa, Adilson, additional, Doley, Jennifer, additional, Fatyga, Edyta, additional, Ferreira, Maria Pontes, additional, Gaikwad, Anil Bhanudas, additional, Garud, Mayuresh S., additional, Horas, Konstantin, additional, Hudgins, Samantha, additional, Huhn, Sebastian, additional, Jewell, Dennis E., additional, Joshi, Seema, additional, Juarez-Cedillo, Teresa, additional, Kłósek, Małgorzata, additional, Kokot, Teresa, additional, Kolbow, Kristina, additional, Korzonek-Szlacheta, Ilona, additional, Król, Wojciech, additional, Kubena, Karen S., additional, Kulkarni, Yogesh A., additional, Kuropatnicki, Andrzej Karol, additional, Kurth, Andreas Alois, additional, Lage, Renan, additional, Laguna, Laura, additional, Landmann, Marianne, additional, Lazovic, Djordje, additional, López-Lluch, Guillermo, additional, Machado, Elaine Cristina Faria Abrahão, additional, Mackert, Jessica D., additional, Maier, Gerrit Steffen, additional, Malczyk, Ewa, additional, Manzato, Enzo, additional, Martinez, Kristina B., additional, Maus, Uwe, additional, Maya-Luevano, Ruben, additional, McIntosh, Michael K., additional, McIntosh, W. Alex, additional, Muc-Wierzgoń, Małgorzata, additional, Navinskey, Melissa, additional, Oza, Manisha J., additional, Panickar, Kiran S., additional, Roth, Klaus Edgar, additional, Sarkar, Anwesha, additional, Seeger, Jörn Bengt, additional, Sergi, Giuseppe, additional, Singhal, Kunal, additional, Soenen, Stijn, additional, Sparavigna, Adele, additional, Stewart, Melissa K., additional, Sun, Wai Yan, additional, Szliszka, Ewelina, additional, Veronese, Nicola, additional, Vissavajjhala, Prabhakar, additional, Wang, Yu, additional, Winkler, Gertrud, additional, Witte, A. Veronica, additional, Wong, Chit Wai, additional, Ziesemer, Katrin, additional, Ziółko, Ewa, additional, and Zuliani, Giovanni, additional

Published
2017
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44. Vitamin D and the Elderly Orthopedic Patient

Author

Maier, Gerrit Steffen, primary, Kurth, Andreas Alois, additional, Horas, Konstantin, additional, Kolbow, Kristina, additional, Seeger, Jörn Bengt, additional, Roth, Klaus Edgar, additional, Lazovic, Djordje, additional, and Maus, Uwe, additional

Published
2017
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50. Use of Physiotherapy Prior to Total Knee Arthroplasty-Results of the Prospective FInGK Study

Author

Jacobs, Hannes, Hoffmann, Falk, Lazovic, Djordje, Maus, Uwe, and Seeber, Gesine H.

Subjects
HIP, knee arthroplasty, health services research, RECOMMENDATIONS, PREVALENCE, disease burden, socioeconomic status, osteoarthritis, QUALITY-OF-LIFE, SF-36, DISEASES, MANAGEMENT, physical therapy, BURDEN, PHYSICAL-THERAPY
Abstract

Background: Data regarding physiotherapy (PT) utilization prior to total knee arthroplasty (TKA) are insufficient. Therefore, this study aims to examine which percentage of patients receive PT within 12 months prior to TKA and which factors are associated with its use. Methods: Consecutive patients (>= 18 years) undergoing primary or revision TKA in a German university hospital were recruited. A questionnaire including information on PT utilization, demography, and socioeconomics was collected one day prior to surgery and linked to medical hospital records. Multivariable logistic regression was conducted to determine variables associated with the use of PT. Results: A total of 241 out of 283 (85%) patients participated (60% female; mean age: 68.4 years). Overall, 41% received PT at least once during 12 months prior to TKA, women more frequently than men (48% vs. 29%). Although high disease burden was associated with increased utilization, about one in two in this condition did not receive PT. Multivariable logistic regression showed that age 75+ years, low education level, and moderate-to-severe depressive symptoms were associated with decreased PT utilization. Conclusions: We found low use of recommended PT management in patients prior to TKA. This potential underuse was even higher in some vulnerable subgroups, indicating inequalities. Prescribers as well as patients should integrate PT more consistently into osteoarthritis management.

Published
2022

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