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5. ANTIBODIES TO HUMAN T-LYMPHOTROPIC VIRUS TYPE-I IN PATIENTS WITH TROPICAL SPASTIC PARAPARESIS

Author

Gessain, A., Vernant, J.C., Maurs, L., Barin, F., Gout, O., Calender, A., and De Thé, G.

Abstract

10 out of 17 (59%) patients with tropical spastic paraparesis (TSP) had antibodies to human T-lymphotropic virus-I (HTLV-I), as did 5 out of 5 TSP patients with systemic symptoms. Only 13 out of 303 (4%) controls, made up of blood donors, medical personnel, and other neurological patients, had such antibodies. These findings suggest either that HTLV-I is neurotropic or that the virus or a related one contributes to the pathogenesis of TSP.

Published
1985
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7. Intrathecal Synthesis of Antibodies to Human T Lymphotropic Virus Type I and the Presence of IgG Oligoclonal Bands in the Cerebrospinal Fluid of Patients with Endemic Tropical Spastic Paraparesis

Author

Gessain, A., primary, Caudie, C., additional, Gout, O., additional, Vernant, J.-C., additional, Maurs, L., additional, Giordano, C., additional, Malone, G., additional, Tournier-Lasserve, E., additional, Essex, M., additional, and de-The, G., additional

Published
1988
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8. [Tropical spastic paraparesis in Martinique. High prevalence of anti-HTLV-I antibodies].

Author

Vernant JC, Gessain A, Gout O, Maurs L, Buisson G, Barin F, Calender A, and de-Thé G

Subjects
Adult, Female, Humans, Male, Martinique, Muscle Spasticity blood, Muscle Spasticity immunology, Paralysis blood, Paralysis immunology, Antibodies, Viral analysis, Deltaretrovirus immunology, Muscle Spasticity physiopathology, Paralysis physiopathology
Abstract

Owing to the frequent occurrence in tropical countries of subacute spinal cord diseases of unknown origin, a nosological entity called tropical spastic paraparesis has been individualized. Twenty-two cases have been observed in Martinique. The presence in the serum of antibodies directed against human T-cell leukaemia/lymphoma virus (HTLV-I) in 15 of these 22 patients suggests that this lymphotropic virus or a related one might also be neurovirulent.

Published
1986

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